MFS domain-containing protein

Overview


Name	MFS domain-containing protein
Smed ID	SMED30030378
Length (bp)	588

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30030378

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
epidermis	SMED30030378	h1SMcG0004957	dd_Smed_v4_14153_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Category 4 cell	SMED30030378	h1SMcG0004957	dd_Smed_v4_16395_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
Category 4 cell	SMED30030378	h1SMcG0004957	dd_Smed_v4_14153_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

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Homology

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BLAST of MFS domain-containing protein vs. Ensembl Celegans
Match: Y59A8B.21 (pep chromosome:WBcel235:V:17986260:17994546:1 gene:WBGene00013353.1 transcript:Y59A8B.21.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y59A8B.21)

HSP 1 Score: 105.531 bits (262), Expect = 1.242e-26
Identity = 60/169 (35.50%), Postives = 96/169 (56.80%), Query Frame = 2

Query:   62 GAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGT---TMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSF 559
            GA  +H ++GT  TFGN+ PY+ASY++  T  + +   HM+W+ +    F G     M +GG+       R++   G ++++    ++ + I+ +  L  + YG+ +G G GI Y  A++ A+ W P K G+I+GIV  GFGL S IF  IQT  +NP N+ P T D +
Sbjct:   30 GAVSIHLTIGTYHTFGNMLPYMASYMRNFTDPS-VRIEHMMWIPT----FQGCFPFAMVIGGLTSSTFSPRVSAFIGCFLVTSSVALSAYAIQHSFALFFIVYGLLFGLGSGIAYVTAVSTAINWAPDKIGVISGIVAAGFGLSSSIFAPIQTMIVNPLNL-PATKDGY 192

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BLAST of MFS domain-containing protein vs. Ensembl Celegans
Match: F10G7.5 (pep chromosome:WBcel235:II:4693414:4696408:1 gene:WBGene00017369.1 transcript:F10G7.5a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F10G7.5)

HSP 1 Score: 75.0998 bits (183), Expect = 7.256e-16
Identity = 59/180 (32.78%), Postives = 96/180 (53.33%), Query Frame = 2

Query:   35 LVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSI-TVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFENSE 571
            LV G+ C+        + G ++T GNL PY+ SY + +     +  G ++W+ ++ +   MG  M +GG++ERK G R   L GS + +IG   T+++I+ +    LL+ G     G  I YS  +  A +WFP   G+  GI+ GG+G G+FI + +QT +INP +   N    F   +
Sbjct:   21 LVGGVMCM-------VTFGIVYTCGNLLPYLVSYFRWKMYPD-MRTGQLIWLQTLLSGLPMG--MVIGGLVERKFGGRAGALLGSIIYTIGVGSTFYSIQHSYAATLLTMGGIASVGSSIAYSSILPTAQRWFPDNVGLAGGIIIGGYGCGAFILSPLQTTFINPLDYRVNDQGFFTQED 190

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BLAST of MFS domain-containing protein vs. Ensembl Celegans
Match: F10G7.5 (pep chromosome:WBcel235:II:4693542:4696408:1 gene:WBGene00017369.1 transcript:F10G7.5a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F10G7.5)

HSP 1 Score: 75.0998 bits (183), Expect = 7.256e-16
Identity = 59/180 (32.78%), Postives = 96/180 (53.33%), Query Frame = 2

Query:   35 LVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSI-TVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFENSE 571
            LV G+ C+        + G ++T GNL PY+ SY + +     +  G ++W+ ++ +   MG  M +GG++ERK G R   L GS + +IG   T+++I+ +    LL+ G     G  I YS  +  A +WFP   G+  GI+ GG+G G+FI + +QT +INP +   N    F   +
Sbjct:   21 LVGGVMCM-------VTFGIVYTCGNLLPYLVSYFRWKMYPD-MRTGQLIWLQTLLSGLPMG--MVIGGLVERKFGGRAGALLGSIIYTIGVGSTFYSIQHSYAATLLTMGGIASVGSSIAYSSILPTAQRWFPDNVGLAGGIIIGGYGCGAFILSPLQTTFINPLDYRVNDQGFFTQED 190

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BLAST of MFS domain-containing protein vs. Ensembl Celegans
Match: F10G7.5 (pep chromosome:WBcel235:II:4693414:4696408:1 gene:WBGene00017369.1 transcript:F10G7.5b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F10G7.5)

HSP 1 Score: 74.7146 bits (182), Expect = 8.793e-16
Identity = 59/180 (32.78%), Postives = 96/180 (53.33%), Query Frame = 2

Query:   35 LVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSI-TVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFENSE 571
            LV G+ C+        + G ++T GNL PY+ SY + +     +  G ++W+ ++ +   MG  M +GG++ERK G R   L GS + +IG   T+++I+ +    LL+ G     G  I YS  +  A +WFP   G+  GI+ GG+G G+FI + +QT +INP +   N    F   +
Sbjct:   35 LVGGVMCM-------VTFGIVYTCGNLLPYLVSYFRWKMYPD-MRTGQLIWLQTLLSGLPMG--MVIGGLVERKFGGRAGALLGSIIYTIGVGSTFYSIQHSYAATLLTMGGIASVGSSIAYSSILPTAQRWFPDNVGLAGGIIIGGYGCGAFILSPLQTTFINPLDYRVNDQGFFTQED 204

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BLAST of MFS domain-containing protein vs. Ensembl Celegans
Match: mct-6 (MonoCarboxylate Transporter family [Source:UniProtKB/TrEMBL;Acc:O17328])

HSP 1 Score: 53.5286 bits (127), Expect = 2.277e-8
Identity = 47/162 (29.01%), Postives = 77/162 (47.53%), Query Frame = 2

Query:   56 VSGAFLLH-FSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLG-GILE----RKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYIN 523
            V G+F +H F+ G +++FG L              T +   H     +  +  + T +TLG G L      K G RIT + G+ +  +G  ++YF     +W ++++ GV  GTG G+ Y  A+     +F  KR +  GI   G G+G+ +F  I   +IN
Sbjct:   27 VLGSFFVHVFADGFVYSFGVLV------------ETLMEEFHASNTMAALIISLLTGLTLGSGPLASAVCNKYGCRITTITGAGVAFVGCALSYFATA--MWHIVITVGVIMGTGFGLMYCPAIVIVTMYFENKRSLATGIAVAGAGVGTVLFAPINAFFIN 174

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BLAST of MFS domain-containing protein vs. Ensembl Fly
Match: CG13907 (gene:FBgn0035173 transcript:FBtr0072593)

HSP 1 Score: 46.9802 bits (110), Expect = 4.897e-6
Identity = 41/144 (28.47%), Postives = 64/144 (44.44%), Query Frame = 2

Query:   89 GTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGI---LERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQT 511
            G  +TFG       +Y            G + WV S+     G  ++ G I   L  K G R  C+ GS +  I  +++ F+   N+ +++ +YG   G G G+ Y  A+ A   +F  KR +  GI   G G G+F F  + T
Sbjct:   93 GIAYTFGIFLEEFVAYFHE-------GKGTVAWVGSL---LSGVYLSAGPIVSALANKYGCRAVCIAGSIIACIAFVLSTFS--TNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFETKRSLATGIAVCGSGFGTFAFAPLAT 224

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BLAST of MFS domain-containing protein vs. Ensembl Fly
Match: CG13907 (gene:FBgn0035173 transcript:FBtr0345005)

HSP 1 Score: 46.9802 bits (110), Expect = 4.897e-6
Identity = 41/144 (28.47%), Postives = 64/144 (44.44%), Query Frame = 2

Query:   89 GTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGI---LERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQT 511
            G  +TFG       +Y            G + WV S+     G  ++ G I   L  K G R  C+ GS +  I  +++ F+   N+ +++ +YG   G G G+ Y  A+ A   +F  KR +  GI   G G G+F F  + T
Sbjct:   93 GIAYTFGIFLEEFVAYFHE-------GKGTVAWVGSL---LSGVYLSAGPIVSALANKYGCRAVCIAGSIIACIAFVLSTFS--TNVSMLMATYGFMGGFGFGMIYLPAVVAVGYYFETKRSLATGIAVCGSGFGTFAFAPLAT 224

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BLAST of MFS domain-containing protein vs. Ensembl Fly
Match: hrm (gene:FBgn0033028 transcript:FBtr0086072)

HSP 1 Score: 46.595 bits (109), Expect = 4.985e-6
Identity = 28/104 (26.92%), Postives = 48/104 (46.15%), Query Frame = 2

Query:  185 WVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIF 496
            W+ ++  F   +   +  IL  K   R   L G    S+G I++++    +I  + +SYGV  G G G+++   +     +F   RG+  G+   G  LGS I 
Sbjct:   96 WIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGMILSFWA--SSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIIL 197

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BLAST of MFS domain-containing protein vs. Ensembl Fly
Match: hrm (gene:FBgn0033028 transcript:FBtr0345359)

HSP 1 Score: 46.595 bits (109), Expect = 4.985e-6
Identity = 28/104 (26.92%), Postives = 48/104 (46.15%), Query Frame = 2

Query:  185 WVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIF 496
            W+ ++  F   +   +  IL  K   R   L G    S+G I++++    +I  + +SYGV  G G G+++   +     +F   RG+  G+   G  LGS I 
Sbjct:   96 WIPALCYFLYSSLGPVSSILSVKYSYRTVTLLGGASASLGMILSFWA--SSIEFLYISYGVLVGIGAGLSFPPTVYIVTSYFAKLRGLANGLCISGSALGSIIL 197

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BLAST of MFS domain-containing protein vs. Ensembl Fly
Match: CG10019 (gene:FBgn0031568 transcript:FBtr0273188)

HSP 1 Score: 46.595 bits (109), Expect = 6.556e-6
Identity = 35/148 (23.65%), Postives = 67/148 (45.27%), Query Frame = 2

Query:   65 AFLLH-FSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLI 505
            +FL+H  + G   ++G L  Y   YL   +    +  G + W    +V  + T+  +   L RK   R+  + G  +M +G + T F  +     V+ SYG+ +G G+ +    +      +F  +R  +  +   G G+G  +F++I
Sbjct:  396 SFLVHILTTGLQLSYGLLWFYAVQYLHNTSGIELL--GALSW----SVSMVATSFVVS--LCRKRSIRLLSIVGGLVMPLGILFTSFATE--FGQVVFSYGIVFGVGVAMVREASTVMLGNYFKRRRQFVEMVAMSGEGVGIALFSVI 533

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BLAST of MFS domain-containing protein vs. Ensembl Zebrafish
Match: SLC16A6 (monocarboxylate transporter 7-like [Source:NCBI gene;Acc:103911912])

HSP 1 Score: 49.2914 bits (116), Expect = 7.886e-7
Identity = 37/131 (28.24%), Postives = 67/131 (51.15%), Query Frame = 2

Query:   80 FSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGG 472
            F L  +FT+G +  +   +LK   S+   TN  + W+ SI VF M  T  L  +L  + G +   + G +++S+GTI T FT   +I  + L+ G+  G G  +T+   +    ++F  +R ++  + + G
Sbjct:   33 FFLVEVFTYGVIKSF-GIFLKDLMSDFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGFQPVVMFGGFLISLGTISTAFT--SSINQMYLTIGIVTGLGYCLTFLPTVTILSQYFSRRRSVVTAMASTG 160

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Query:   80 FSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGG 472
            F L  +FT+G +  +   +LK   S+   TN  + W+ SI VF M  T  L  +L  + G +   + G +++S+GTI T FT   +I  + L+ G+  G G  +T+   +    ++F  +R ++  + + G
Sbjct:   33 FFLVEVFTYGVIKSF-GIFLKDLMSDFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGFQPVVMFGGFLISLGTISTAFT--SSINQMYLTIGIVTGLGYCLTFLPTVTILSQYFSRRRSVVTAMASTG 160

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BLAST of MFS domain-containing protein vs. Ensembl Zebrafish
Match: slc16a6a (solute carrier family 16 member 6a [Source:NCBI gene;Acc:564872])

HSP 1 Score: 48.521 bits (114), Expect = 1.832e-6
Identity = 37/131 (28.24%), Postives = 67/131 (51.15%), Query Frame = 2

Query:   80 FSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGG 472
            F L  +FT+G +  +   +LK   S+   TN  + W+ SI VF M  T  L  +L  + G +   + G +++S+GTI T FT   +I  + L+ G+  G G  +T+   +    ++F  +R ++  + + G
Sbjct:   33 FFLVEVFTYGVIKSF-GIFLKDLMSDFNETNSRVSWIISICVFVMTFTAPLSTMLSNRFGFQPVVMFGGFLISLGTISTAFT--SSINQMYLTIGIVTGLGYCLTFLPTVTILSQYFSRRRSVVIAMASTG 160

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BLAST of MFS domain-containing protein vs. Ensembl Zebrafish
Match: slc16a9a (solute carrier family 16 member 9a [Source:ZFIN;Acc:ZDB-GENE-040426-1364])

HSP 1 Score: 46.595 bits (109), Expect = 7.177e-6
Identity = 27/89 (30.34%), Postives = 47/89 (52.81%), Query Frame = 2

Query:  257 GSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYIN 523
            G+R   +    M++ G +++ F    NI  ++ SYG+  G G G+ Y+  +    ++F  +RG+  GIVT G  +G FI+  +Q   I 
Sbjct:   80 GARPVTIFSGVMVAGGLMLSAFA--PNISFLIFSYGIVVGMGCGLVYAATLTITCQYFDKRRGLALGIVTTGTSVGGFIYATLQNELIE 166

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BLAST of MFS domain-containing protein vs. Ensembl Zebrafish
Match: slc16a9b (solute carrier family 16 member 9b [Source:ZFIN;Acc:ZDB-GENE-040801-69])

HSP 1 Score: 46.2098 bits (108), Expect = 8.523e-6
Identity = 26/88 (29.55%), Postives = 47/88 (53.41%), Query Frame = 2

Query:  257 GSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYI 520
            G+R   +    M+S G +++ F    N+  ++ SYG+  G G G+ Y+  +    ++F  +RG+  GIVT G  +G F++   Q  +I
Sbjct:   80 GARPVTIFSGVMVSGGLMLSAFA--PNVQFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGIVTTGTSVGGFLYAAAQNEFI 165

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BLAST of MFS domain-containing protein vs. Ensembl Mouse
Match: Slc16a6 (solute carrier family 16 (monocarboxylic acid transporters), member 6 [Source:MGI Symbol;Acc:MGI:2144585])

HSP 1 Score: 47.3654 bits (111), Expect = 3.759e-6
Identity = 29/116 (25.00%), Postives = 55/116 (47.41%), Query Frame = 2

Query:  167 TNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTA 514
            +N  + W+ SI VF +  T  L  +L  + G R+  + G  ++S+G I   F+  Q ++ + +S GV  G G   ++   +    ++F  +R ++  + + G     F F    TA
Sbjct:   59 SNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFS--QRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITA 172

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BLAST of MFS domain-containing protein vs. Ensembl Mouse
Match: Slc16a6 (solute carrier family 16 (monocarboxylic acid transporters), member 6 [Source:MGI Symbol;Acc:MGI:2144585])

HSP 1 Score: 46.595 bits (109), Expect = 7.567e-6
Identity = 29/116 (25.00%), Postives = 55/116 (47.41%), Query Frame = 2

Query:  167 TNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTA 514
            +N  + W+ SI VF +  T  L  +L  + G R+  + G  ++S+G I   F+  Q ++ + +S GV  G G   ++   +    ++F  +R ++  + + G     F F    TA
Sbjct:  143 SNSKISWIISICVFVLTFTAPLSTVLSNRFGHRLVVMAGGLLISLGMITASFS--QRVYHMYISIGVISGLGYCFSFLPTVTILSQYFDKRRSVVTAVASTGECFAVFAFAPAITA 256

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BLAST of MFS domain-containing protein vs. UniProt/SwissProt
Match: sp|A0LNN5|SFMCT_SYNFM (L-lactate transporter OS=Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB) OX=335543 GN=Sfum_3364 PE=1 SV=1)

HSP 1 Score: 56.9954 bits (136), Expect = 1.476e-8
Identity = 38/130 (29.23%), Postives = 62/130 (47.69%), Query Frame = 2

Query:  134 YLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYIN 523
            ++K   +    +   +   F+I     G      G L  KMG R   + G  +++IG I++ F   Q+ + + ++YGV  G G G+ Y   +A A KW+P +R +  G    G GLGSF+   + T  I 
Sbjct:   34 FIKPLNAEFGWSRAEIAMAFAICCLIFGLMTFPAGRLSDKMGPRKVVMTGGVLLAIGFILSGFI--QSKYQLYITYGVIAGFGGGMIYLPPIATAPKWWPDRRALATGFAVVGLGLGSFLMGPLATYIIE 161

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BLAST of MFS domain-containing protein vs. UniProt/SwissProt
Match: sp|P37662|YHJX_ECOLI (Uncharacterized MFS-type transporter YhjX OS=Escherichia coli (strain K12) OX=83333 GN=yhjX PE=1 SV=1)

HSP 1 Score: 54.299 bits (129), Expect = 1.169e-7
Identity = 35/154 (22.73%), Postives = 74/154 (48.05%), Query Frame = 2

Query:   62 GAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYIN 523
            G  +  F+LG+++T+   +  +++ L    S        + + F +    +  + ++ G L+ + G +   +    ++ +G  +T  +   N+ ++ LS GV  G   G  Y + ++  +KWFP ++G+I+    G +GLGS  F  I T  + 
Sbjct:   16 GTIITQFALGSVYTWSLFNGALSAKLDAPVS-------QVAFSFGLLSLGLAISSSVAGKLQERFGVKRVTMASGILLGLGFFLTAHS--DNLMMLWLSAGVLVGLADGAGYLLTLSNCVKWFPERKGLISAFAIGSYGLGSLGFKFIDTQLLE 160

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BLAST of MFS domain-containing protein vs. UniProt/SwissProt
Match: sp|Q51330|OXLT_OXAFO (Oxalate:formate antiporter OS=Oxalobacter formigenes OX=847 GN=oxlT PE=1 SV=3)

HSP 1 Score: 51.9878 bits (123), Expect = 7.748e-7
Identity = 35/121 (28.93%), Postives = 56/121 (46.28%), Query Frame = 2

Query:  134 YLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIF 496
            Y      N  ++   +   F+++      +   GG    K G RI  + G  M+  G   T+  +  ++  +   Y +A G G+GI Y +AM  A +WFP KRG+ +G    G+GLG   F
Sbjct:   40 YANPVKDNLGVSLAAVQTAFTLSQVIQAGSQPGGGYFVDKFGPRIPLMFGGAMVLAGW--TFMGMVDSVPALYALYTLA-GAGVGIVYGIAMNTANRWFPDKRGLASGFTAAGYGLGVLPF 157

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BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A0H3YF06 (Slc16a-5 (Fragment) OS=Schmidtea mediterranea OX=79327 GN=slc16a-5 PE=2 SV=1)

HSP 1 Score: 200.29 bits (508), Expect = 1.052e-58
Identity = 94/181 (51.93%), Postives = 128/181 (70.72%), Query Frame = 2

Query:   41 KGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPN----TTDSFENSE 571
            KG  C+ G FL+HFSLG+++TFGN+SPYIASY++ R     + N  MVW+F+  +   G TM+ GG+L++K+GSR T L G  +MS   I+TYFTI+ NI++ +L+YGV +G G+GI YSV +AA++KWFP  +G++ G+V  GFGLGS  FN IQT YINP NISPN     TD +   E
Sbjct:   11 KGYLCILGGFLIHFSLGSIYTFGNISPYIASYMRSRPVTQSVKNSDMVWIFAFALASQGLTMSFGGVLDKKVGSRFTVLIGCCIMSASVILTYFTIQANIYVTILTYGVIFGFGVGIAYSVVLAASIKWFPNNKGLVIGVVVAGFGLGSLAFNQIQTLYINPQNISPNFTKEDTDRYFTDE 191

[Close]

BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A1I8HYG0 (MFS domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 6.389e-55
Identity = 80/170 (47.06%), Postives = 125/170 (73.53%), Query Frame = 2

Query:   41 KGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTT 550
            KGI  V G FL+HF+LGT++TFGN+SPY+ SY++  + + WI      W+F +++F  G +M  GG++E+++G+R+T L GSW+MS+G +++YF +K ++ L++++YG+ +G G GI Y+VA+AA+M WFP +RG++ GIV  GFG GS +F+  QT YINP N+  N T
Sbjct:    6 KGIGAVIGGFLIHFTLGTLYTFGNMSPYVVSYMRLHSHSKWIGYPDATWIFGLSIFGQGASMAFGGLIEKRIGARLTALLGSWIMSLGVLLSYFAVKSHLGLLVVTYGLLFGVGTGIAYAVAIAASMSWFPSRRGLVGGIVVAGFGGGSLVFDQFQTLYINPDNVRANVT 175

[Close]

BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A1I8HL50 (MFS domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1)

HSP 1 Score: 190.274 bits (482), Expect = 6.811e-55
Identity = 80/170 (47.06%), Postives = 125/170 (73.53%), Query Frame = 2

Query:   41 KGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTT 550
            KGI  V G FL+HF+LGT++TFGN+SPY+ SY++  + + WI      W+F +++F  G +M  GG++E+++G+R+T L GSW+MS+G +++YF +K ++ L++++YG+ +G G GI Y+VA+AA+M WFP +RG++ GIV  GFG GS +F+  QT YINP N+  N T
Sbjct:    6 KGIGAVIGGFLIHFTLGTLYTFGNMSPYVVSYMRLHSHSKWIGYPDATWIFGLSIFGQGASMAFGGLIEKRIGARLTALLGSWIMSLGVLLSYFAVKSHLGLLVVTYGLLFGVGTGIAYAVAIAASMSWFPSRRGLVGGIVVAGFGGGSLVFDQFQTLYINPDNVRANVT 175

[Close]

BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A267H5U2 (MFS domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000477g2 PE=4 SV=1)

HSP 1 Score: 189.889 bits (481), Expect = 7.505e-55
Identity = 80/170 (47.06%), Postives = 125/170 (73.53%), Query Frame = 2

Query:   41 KGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTT 550
            KGI  V G FL+HF+LGT++TFGN+SPY+ SY++  + + WI      W+F +++F  G +M  GG++E+++G+R+T L GSW+MS+G +++YF +K ++ L++++YG+ +G G GI Y+VA+AA+M WFP +RG++ GIV  GFG GS +F+  QT YINP N+  N T
Sbjct:    8 KGIGAVIGGFLIHFTLGTLYTFGNMSPYVVSYMRLHSHSKWIGYPDATWIFGLSIFGQGASMAFGGLIEKRIGARLTALLGSWIMSLGVLLSYFAVKSHLGLLVVTYGLLFGVGTGIAYAVAIAASMSWFPSRRGLVGGIVVAGFGGGSLVFDQFQTLYINPDNVRANVT 177

[Close]

BLAST of MFS domain-containing protein vs. TrEMBL
Match: A0A267DK45 (MFS domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000477g4 PE=4 SV=1)

HSP 1 Score: 186.422 bits (472), Expect = 2.503e-53
Identity = 78/168 (46.43%), Postives = 123/168 (73.21%), Query Frame = 2

Query:   47 ISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTT 550
            I  V G FL+HF+LGT++TFGN+SPY+ SY++  + + WI      W+F +++F  G +M  GG++E+++G+R+T L GSW+MS+G +++YF +K ++ L++++YG+ +G G GI Y+VA+AA+M WFP +RG++ GIV  GFG GS +F+  QT YINP N+  N T
Sbjct:    1 IGAVIGGFLIHFTLGTLYTFGNMSPYVVSYMRLHSHSKWIGYPDATWIFGLSIFGQGASMAFGGLIEKRIGARLTALLGSWIMSLGVLLSYFAVKSHLGLLVVTYGLLFGVGTGIAYAVAIAASMSWFPSRRGLVGGIVVAGFGGGSLVFDQFQTLYINPDNVRANVT 168

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Cavefish
Match: ENSAMXT00000010927.2 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02002229.1:6659:13971:1 gene:ENSAMXG00000010636.2 transcript:ENSAMXT00000010927.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 48.521 bits (114), Expect = 1.448e-6
Identity = 31/113 (27.43%), Postives = 57/113 (50.44%), Query Frame = 2

Query:  134 YLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGG 472
            +L+   S+   TN  + W+ SI VF M  T  L  +L  + G R   + G  ++S+GTI T FT   +I  + ++ G+  G G  +T+   +    ++F  +R ++  + + G
Sbjct:   50 FLQDLMSHFEETNSRVSWIVSICVFVMTFTAPLSTVLSNRFGCRPVVMFGGLLISLGTISTAFT--HSINQMYITVGLVSGLGYCLTFLPTVTILSQYFNKRRSLVTSVASTG 160

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Cavefish
Match: slc16a6b (monocarboxylate transporter 7-like [Source:NCBI gene;Acc:103045885])

HSP 1 Score: 48.521 bits (114), Expect = 1.581e-6
Identity = 31/113 (27.43%), Postives = 57/113 (50.44%), Query Frame = 2

Query:  134 YLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGG 472
            +L+   S+   TN  + W+ SI VF M  T  L  +L  + G R   + G  ++S+GTI T FT   +I  + ++ G+  G G  +T+   +    ++F  +R ++  + + G
Sbjct:   50 FLQDLMSHFEETNSRVSWIVSICVFVMTFTAPLSTVLSNRFGCRPVVMFGGLLISLGTISTAFT--HSINQMYITVGLVSGLGYCLTFLPTVTILSQYFNKRRSLVTSVASTG 160

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Cavefish
Match: slc16a6a (monocarboxylate transporter 7-like [Source:NCBI gene;Acc:103022929])

HSP 1 Score: 47.7506 bits (112), Expect = 2.149e-6
Identity = 35/131 (26.72%), Postives = 64/131 (48.85%), Query Frame = 2

Query:   80 FSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGG 472
            F L  +FT+G +  +   +LK        +N  + W+ SI VF M  T  L  +L  + G +   + G  ++SIGTI T FT   +I  + ++ G+  G G  +T+   +    ++F  +R ++  + + G
Sbjct:   33 FFLVEVFTYGVIKSF-GIFLKDLMCEFNESNSRVSWIVSICVFVMAFTAPLSTVLSNRFGFQPVVILGGLLISIGTISTAFT--SHITQIYITIGIVAGLGYCLTFLPTVTILSQYFSKRRSLVTAMASTG 160

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Cavefish
Match: slc16a6a (monocarboxylate transporter 7-like [Source:NCBI gene;Acc:103022929])

HSP 1 Score: 47.7506 bits (112), Expect = 2.165e-6
Identity = 35/131 (26.72%), Postives = 64/131 (48.85%), Query Frame = 2

Query:   80 FSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGG 472
            F L  +FT+G +  +   +LK        +N  + W+ SI VF M  T  L  +L  + G +   + G  ++SIGTI T FT   +I  + ++ G+  G G  +T+   +    ++F  +R ++  + + G
Sbjct:   33 FFLVEVFTYGVIKSF-GIFLKDLMCEFNESNSRVSWIVSICVFVMAFTAPLSTVLSNRFGFQPVVILGGLLISIGTISTAFT--SHITQIYITIGIVAGLGYCLTFLPTVTILSQYFSKRRSLVTAMASTG 160

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Nematostella
Match: EDO28509 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T697])

HSP 1 Score: 50.8322 bits (120), Expect = 8.198e-8
Identity = 43/133 (32.33%), Postives = 66/133 (49.62%), Query Frame = 2

Query:   86 LGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLG 484
            +GT+ +FG L P     L R    T        W+ S+ V  M  +  + G L  K+GSR+T   G+ + S G +++ F     IW+V L+YG+  G G G+ ++   +   K+F   R +  GIV  G GLG
Sbjct:    1 MGTVLSFGVLYPAFLKDLGRSREKT-------AWIGSLPVSIMSVSAVVSGALCDKLGSRLTGYLGTVVCSAGLLLSSFA--PEIWIVYLTYGLLLGVGTGLIFTSIFSITAKYFNRFRALAVGIVGSGEGLG 124

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Nematostella
Match: EDO39675 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9B6])

HSP 1 Score: 48.9062 bits (115), Expect = 4.150e-7
Identity = 42/133 (31.58%), Postives = 65/133 (48.87%), Query Frame = 2

Query:   86 LGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLG 484
            +GT+ +FG L P     L R    T        W+ S+ V  M  +  + G L  K+GSR+T   G+ + S G + ++      IW+V L+YG+  G G G+ ++   +   K+F   R +  GIV  G GLG
Sbjct:    1 MGTVLSFGVLYPAFLKDLGRSREKT-------AWIGSLPVSIMSVSAVVSGALCDKLGSRLTGYLGTVVCSAGLLSSF---APEIWIVYLTYGLLLGVGTGLIFTSIFSITAKYFNRFRALAVGIVGSGEGLG 123

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Nematostella
Match: EDO48450 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIS4])

HSP 1 Score: 46.9802 bits (110), Expect = 5.159e-7
Identity = 37/145 (25.52%), Postives = 64/145 (44.14%), Query Frame = 2

Query:   47 ISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITV---FFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGG 472
            I C S A  +  + G  F++G L P    Y K  +  T        WV S+ +   F  G+   + G++ +K G R+TC+ G    +IG  V+    K +   +  SY + +G G    ++ +     ++F     +  G+VT G
Sbjct:    2 IVCCSSAVCVALATGVTFSYGVLLPVFMDYFKENSEKT-------AWVGSLAICSTFLFGS---VAGMIVQKFGCRLTCVIGGLSCAIGLGVSSLVDKMD--YLFGSYSLLFGFGCSCLFNSSFVVVTRYFDRYLSLATGLVTAG 134

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Nematostella
Match: EDO38356 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SD36])

HSP 1 Score: 46.9802 bits (110), Expect = 1.682e-6
Identity = 41/144 (28.47%), Postives = 64/144 (44.44%), Query Frame = 2

Query:   53 CVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLG 484
            CVS +      LG    F  + P + +Y          +   + WV SIT         L G+L  K+  R+T + GS    I  ++T FT K ++  +  SY V YG G  + Y   + A  ++F  +RG+  G +T G  +G
Sbjct:  429 CVSASISTIIILGFSHCFAVVMPVLLNYFND-------SRQKIAWVGSITQCLTFFASPLAGLLIGKLSFRVTAVLGSLTCCISLVLTSFT-KASLH-IFFSYSVLYGLGSCLFYMSCVYAVAEYFEKRRGLALGFLTSGISVG 563

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Nematostella
Match: EDO49501 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGB3])

HSP 1 Score: 46.2098 bits (108), Expect = 3.005e-6
Identity = 43/170 (25.29%), Postives = 73/170 (42.94%), Query Frame = 2

Query:   53 CVSGAFLLHFSLGTMFTFGNL-SPYIASYLK---------RRT---SNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYIN 523
            C +  F +   LGT++TFG L  P +A +           RR+   S   +      WV SI  F +     L  +L  + G R   + G  + S+G +++ F    +I  +  +YG+  G G  ++Y  A+     +F  KR +  GI   G  +G+ I   +Q   + 
Sbjct:   59 CAAAFFDIFIVLGTLYTFGVLYVPLLAQFKASKAETGLDGRRSLLKSKLDLFRRLEAWVGSIGQFSIYFVCYLSSLLAERFGCRKITIVGGIITSLGLLISSFCT--SIKSMYFTYGILVGIGSSLSYLPALVMVAFYFEKKRSLATGIAAAGGNIGALILAPLQQTLVE 226

[Close]

BLAST of MFS domain-containing protein vs. Ensembl Medaka
Match: slc16a9a (solute carrier family 16 member 9 [Source:NCBI gene;Acc:101165170])

HSP 1 Score: 46.2098 bits (108), Expect = 7.374e-6
Identity = 27/88 (30.68%), Postives = 46/88 (52.27%), Query Frame = 2

Query:  257 GSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYI 520
            G+R        M++ G +++ F    N+  ++ SYG+  G G G+ YS  +    ++F  +RG+  GIVT G  +G+FI+   Q   I
Sbjct:   78 GARPVTFFSGVMVAGGLMLSAFA--PNVPFLMFSYGIVVGLGCGLVYSATLTITCQYFDKRRGLALGIVTTGTSIGAFIYATAQNELI 163

[Close]

BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060698.1 (SMESG000060698.1)

HSP 1 Score: 335.109 bits (858), Expect = 6.577e-115
Identity = 168/182 (92.31%), Postives = 170/182 (93.41%), Query Frame = 2

Query:   20 MKVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFEN 565
            MKVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMM           ++NIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFE 
Sbjct:    1 MKVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMM-----------RKNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFEK 171

[Close]

BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060698.1 (SMESG000060698.1)

HSP 1 Score: 334.724 bits (857), Expect = 8.253e-115
Identity = 168/182 (92.31%), Postives = 170/182 (93.41%), Query Frame = 2

Query:   20 MKVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFEN 565
            MKVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMM           ++NIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFE 
Sbjct:    1 MKVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMM-----------RKNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFEK 171

[Close]

BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060694.1 (SMESG000060694.1)

HSP 1 Score: 276.559 bits (706), Expect = 9.573e-92
Identity = 130/182 (71.43%), Postives = 153/182 (84.07%), Query Frame = 2

Query:   23 KVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCG-SWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFEN 565
            KV   +KGI CV GAFLLHFSLGT++TFGNLSPYIASYLK RT NTWI NGH+VWVFS+ VFF+G TM+ GG LE+K+G+RITCLC   +  SIGTI TYF+IK  IWLV+ SYG+AYG G GITYSVA+A A+KWFP +RGM++GIVTGGFGLGS IFNLIQTAYINP N++PN+TD +E 
Sbjct:    7 KVDRKIKGIFCVIGAFLLHFSLGTVYTFGNLSPYIASYLKYRTDNTWINNGHLVWVFSLNVFFLGLTMSFGGFLEKKIGARITCLCDIQFFYSIGTISTYFSIKSGIWLVIFSYGIAYGFGTGITYSVAVATAIKWFPKRRGMVSGIVTGGFGLGSLIFNLIQTAYINPKNVAPNSTDLYEK 188

[Close]

BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060699.1 (SMESG000060699.1)

HSP 1 Score: 254.603 bits (649), Expect = 2.660e-83
Identity = 113/182 (62.09%), Postives = 149/182 (81.87%), Query Frame = 2

Query:   20 MKVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFEN 565
            +++ N  +GISCV+G F LHFSLGT +TFGN+SPY+ASYLK RTSNTW+ +GHMVWVF+ +  F+G  M+LGG+LE+K+G+RITCL G W MS+GTI+TY+ +K NIW V+++YGV +G G G+TYSVA++AAMKWFP K+GM+AG V  G+GLGS IFN++QT YINP N+SPN T + E 
Sbjct:    2 VRLGNTARGISCVTGGFFLHFSLGTFYTFGNISPYMASYLKYRTSNTWVNSGHMVWVFAFSALFLGLIMSLGGMLEKKVGARITCLIGGWSMSLGTILTYYAVKTNIWAVIVTYGVIFGGGSGLTYSVAISAAMKWFPTKKGMVAGAVAAGYGLGSLIFNIVQTKYINPFNVSPNKTSTVEK 183

[Close]

BLAST of MFS domain-containing protein vs. Planmine SMEST
Match: SMESG000060699.1 (SMESG000060699.1)

HSP 1 Score: 254.603 bits (649), Expect = 3.280e-83
Identity = 113/182 (62.09%), Postives = 149/182 (81.87%), Query Frame = 2

Query:   20 MKVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWITNGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTYFTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTGGFGLGSFIFNLIQTAYINPTNISPNTTDSFEN 565
            +++ N  +GISCV+G F LHFSLGT +TFGN+SPY+ASYLK RTSNTW+ +GHMVWVF+ +  F+G  M+LGG+LE+K+G+RITCL G W MS+GTI+TY+ +K NIW V+++YGV +G G G+TYSVA++AAMKWFP K+GM+AG V  G+GLGS IFN++QT YINP N+SPN T + E 
Sbjct:    2 VRLGNTARGISCVTGGFFLHFSLGTFYTFGNISPYMASYLKYRTSNTWVNSGHMVWVFAFSALFLGLIMSLGGMLEKKVGARITCLIGGWSMSLGTILTYYAVKTNIWAVIVTYGVIFGGGSGLTYSVAISAAMKWFPTKKGMVAGAVAAGYGLGSLIFNIVQTKYINPFNVSPNKTSTVEK 183

The following BLAST results are available for this feature:

BLAST of MFS domain-containing protein vs. Ensembl Human
BLAST of MFS domain-containing protein vs. Ensembl Celegans
BLAST of MFS domain-containing protein vs. Ensembl Fly
BLAST of MFS domain-containing protein vs. Ensembl Zebrafish
BLAST of MFS domain-containing protein vs. Ensembl Xenopus
BLAST of MFS domain-containing protein vs. Ensembl Mouse
BLAST of MFS domain-containing protein vs. UniProt/SwissProt
BLAST of MFS domain-containing protein vs. TrEMBL
BLAST of MFS domain-containing protein vs. Ensembl Cavefish
BLAST of MFS domain-containing protein vs. Ensembl Sea Lamprey
BLAST of MFS domain-containing protein vs. Ensembl Yeast
BLAST of MFS domain-containing protein vs. Ensembl Nematostella
BLAST of MFS domain-containing protein vs. Ensembl Medaka
BLAST of MFS domain-containing protein vs. Planmine SMEST

BLAST of MFS domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of MFS domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Y59A8B.21	1.242e-26	35.50	pep chromosome:WBcel235:V:17986260:17994546:1 gene...	[more]
F10G7.5	7.256e-16	32.78	pep chromosome:WBcel235:II:4693414:4696408:1 gene:...	[more]
F10G7.5	7.256e-16	32.78	pep chromosome:WBcel235:II:4693542:4696408:1 gene:...	[more]
F10G7.5	8.793e-16	32.78	pep chromosome:WBcel235:II:4693414:4696408:1 gene:...	[more]
mct-6	2.277e-8	29.01	MonoCarboxylate Transporter family [Source:UniPro...	[more]

BLAST of MFS domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG13907	4.897e-6	28.47	gene:FBgn0035173 transcript:FBtr0072593	[more]
CG13907	4.897e-6	28.47	gene:FBgn0035173 transcript:FBtr0345005	[more]
hrm	4.985e-6	26.92	gene:FBgn0033028 transcript:FBtr0086072	[more]
hrm	4.985e-6	26.92	gene:FBgn0033028 transcript:FBtr0345359	[more]
CG10019	6.556e-6	23.65	gene:FBgn0031568 transcript:FBtr0273188	[more]

BLAST of MFS domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
SLC16A6	7.886e-7	28.24	monocarboxylate transporter 7-like [Source:NCBI ge...	[more]
SLC16A6	7.886e-7	28.24	monocarboxylate transporter 7-like [Source:NCBI ge...	[more]
slc16a6a	1.832e-6	28.24	solute carrier family 16 member 6a [Source:NCBI ge...	[more]
slc16a9a	7.177e-6	30.34	solute carrier family 16 member 9a [Source:ZFIN;Ac...	[more]
slc16a9b	8.523e-6	29.55	solute carrier family 16 member 9b [Source:ZFIN;Ac...	[more]

BLAST of MFS domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of MFS domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Slc16a6	3.759e-6	25.00	solute carrier family 16 (monocarboxylic acid tran...	[more]
Slc16a6	7.567e-6	25.00	solute carrier family 16 (monocarboxylic acid tran...	[more]

BLAST of MFS domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3


Match Name	E-value	Identity	Description
sp\|A0LNN5\|SFMCT_SYNFM	1.476e-8	29.23	L-lactate transporter OS=Syntrophobacter fumaroxid...	[more]
sp\|P37662\|YHJX_ECOLI	1.169e-7	22.73	Uncharacterized MFS-type transporter YhjX OS=Esche...	[more]
sp\|Q51330\|OXLT_OXAFO	7.748e-7	28.93	Oxalate:formate antiporter OS=Oxalobacter formigen...	[more]

BLAST of MFS domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0H3YF06	1.052e-58	51.93	Slc16a-5 (Fragment) OS=Schmidtea mediterranea OX=7...	[more]
A0A1I8HYG0	6.389e-55	47.06	MFS domain-containing protein OS=Macrostomum ligna...	[more]
A0A1I8HL50	6.811e-55	47.06	MFS domain-containing protein OS=Macrostomum ligna...	[more]
A0A267H5U2	7.505e-55	47.06	MFS domain-containing protein (Fragment) OS=Macros...	[more]
A0A267DK45	2.503e-53	46.43	MFS domain-containing protein (Fragment) OS=Macros...	[more]

BLAST of MFS domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSAMXT00000010927.2	1.448e-6	27.43	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
slc16a6b	1.581e-6	27.43	monocarboxylate transporter 7-like [Source:NCBI ge...	[more]
slc16a6a	2.149e-6	26.72	monocarboxylate transporter 7-like [Source:NCBI ge...	[more]
slc16a6a	2.165e-6	26.72	monocarboxylate transporter 7-like [Source:NCBI ge...	[more]

BLAST of MFS domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of MFS domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of MFS domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO28509	8.198e-8	32.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39675	4.150e-7	31.58	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48450	5.159e-7	25.52	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38356	1.682e-6	28.47	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49501	3.005e-6	25.29	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of MFS domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
slc16a9a	7.374e-6	30.68	solute carrier family 16 member 9 [Source:NCBI gen...	[more]

BLAST of MFS domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000060698.1	6.577e-115	92.31	SMESG000060698.1	[more]
SMESG000060698.1	8.253e-115	92.31	SMESG000060698.1	[more]
SMESG000060694.1	9.573e-92	71.43	SMESG000060694.1	[more]
SMESG000060699.1	2.660e-83	62.09	SMESG000060699.1	[more]
SMESG000060699.1	3.280e-83	62.09	SMESG000060699.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30030378 ID=SMED30030378|Name=MFS domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=588bp
GTAACTATTCAAAAAAAAAATGAAAGTAAGCAACTTAGTCAAAGGAATAT
CGTGCGTTAGCGGGGCGTTCCTGTTGCATTTCTCTCTGGGGACTATGTTT
ACGTTTGGAAATTTAAGTCCTTATATTGCATCATATTTGAAACGTCGAAC
TTCCAACACATGGATAACAAACGGCCACATGGTTTGGGTTTTTTCCATCA
CTGTGTTCTTCATGGGTACCACAATGACTTTGGGAGGAATATTAGAAAGG
AAGATGGGATCAAGAATTACTTGTTTATGTGGAAGTTGGATGATGAGTAT
TGGAACAATTGTTACATATTTTACAATCAAACAGAATATTTGGTTGGTGT
TGCTTTCTTATGGAGTGGCTTATGGGACAGGAATTGGAATCACATATTCT
GTTGCTATGGCTGCAGCAATGAAATGGTTTCCTCTAAAACGAGGAATGAT
TGCTGGAATTGTCACTGGTGGATTTGGACTAGGTTCCTTTATCTTCAATC
TTATTCAGACGGCTTATATAAATCCAACGAATATTTCACCCAATACAACG
GATTCATTTGAAAATTCTGAATAATGTTCCATTTTGTT

protein sequence of SMED30030378-orf-1

>SMED30030378-orf-1 ID=SMED30030378-orf-1|Name=SMED30030378-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=185bp
MKVSNLVKGISCVSGAFLLHFSLGTMFTFGNLSPYIASYLKRRTSNTWIT
NGHMVWVFSITVFFMGTTMTLGGILERKMGSRITCLCGSWMMSIGTIVTY
FTIKQNIWLVLLSYGVAYGTGIGITYSVAMAAAMKWFPLKRGMIAGIVTG
GFGLGSFIFNLIQTAYINPTNISPNTTDSFENSE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0022857	transmembrane transporter activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000018	Category 4 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036259	MFS_trans_sf
IPR011701	MFS
IPR020846	MFS_dom

Vocabulary: **cellular component**
Term	Definition
GO:0016021	integral component of membrane
GO:0016020	membrane

Vocabulary: **biological process**
Term	Definition
GO:0055085	transmembrane transport

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	GENE3D	G3DSA:1.20.1250.20		coord: 7..176 e-value: 2.3E-14 score: 55.2
None	No IPR available	PANTHER	PTHR11360	MONOCARBOXYLATE TRANSPORTER	coord: 13..170
None	No IPR available	PANTHER	PTHR11360:SF3	OXALATE/FORMATE ANTIPORTER	coord: 13..170
None	No IPR available	CDD	cd17353	MFS_OFA_like	coord: 15..173 e-value: 1.44363E-31 score: 115.4
None	No IPR available	TMHMM	TMhelix		coord: 79..101
None	No IPR available	TMHMM	TMhelix		coord: 53..75
None	No IPR available	TMHMM	TMhelix		coord: 143..162
None	No IPR available	TMHMM	TMhelix		coord: 108..130
None	No IPR available	TMHMM	TMhelix		coord: 10..32
IPR011701	Major facilitator superfamily	PFAM	PF07690	MFS_1	coord: 23..163 e-value: 6.5E-12 score: 45.0
IPR020846	Major facilitator superfamily domain	PROSITE	PS50850	MFS	coord: 8..184 score: 9.187
IPR036259	MFS transporter superfamily	SUPERFAMILY	SSF103473	MFS general substrate transporter	coord: 16..165

Main menu

MFS domain-containing protein

Zeng et. al., 2018

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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