Surfeit locus protein 4

Overview
NameSurfeit locus protein 4
Smed IDSMED30030329
Length (bp)1201
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Surfeit locus protein 4 (SMED30030329) t-SNE clustered cells

Violin plots show distribution of expression levels for Surfeit locus protein 4 (SMED30030329) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Surfeit locus protein 4 (SMED30030329) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Surfeit locus protein 4 (SMED30030329) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30030329

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30030329h1SMcG0007714 dd_Smed_v4_3044_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30030329h1SMcG0007714 dd_Smed_v4_3044_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30030329h1SMcG0007714 dd_Smed_v4_3044_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30030329h1SMcG0007714 dd_Smed_v4_3044_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30030329h1SMcG0007714 dd_Smed_v4_3044_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Human
Match: SURF4 (surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476])

HSP 1 Score: 213.772 bits (543), Expect = 2.113e-66
Identity = 127/266 (47.74%), Postives = 180/266 (67.67%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +N+++   +D AD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   L++LVA+G +TKL A+ LVVWLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Human
Match: SURF4 (surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476])

HSP 1 Score: 213.772 bits (543), Expect = 2.113e-66
Identity = 127/266 (47.74%), Postives = 180/266 (67.67%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +N+++   +D AD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   L++LVA+G +TKL A+ LVVWLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Human
Match: SURF4 (surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476])

HSP 1 Score: 168.703 bits (426), Expect = 1.188e-49
Identity = 109/222 (49.10%), Postives = 150/222 (67.57%), Query Frame = 2 
Query:  215 QWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   L++LVA+G +TKL A+ LVVWLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    4 QWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 225
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Human
Match: SURF4 (surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476])

HSP 1 Score: 168.703 bits (426), Expect = 1.188e-49
Identity = 109/222 (49.10%), Postives = 150/222 (67.57%), Query Frame = 2 
Query:  215 QWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   L++LVA+G +TKL A+ LVVWLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    4 QWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 225
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Human
Match: SURF4 (surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476])

HSP 1 Score: 168.703 bits (426), Expect = 1.188e-49
Identity = 109/222 (49.10%), Postives = 150/222 (67.57%), Query Frame = 2 
Query:  215 QWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   L++LVA+G +TKL A+ LVVWLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    4 QWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 225
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Celegans
Match: sft-4 (Surfeit locus protein 4 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q18864])

HSP 1 Score: 219.164 bits (557), Expect = 7.548e-69
Identity = 126/267 (47.19%), Postives = 181/267 (67.79%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGES-QPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +NE++ + +D A+   RKTR  LP I R CLV+TF+EDG+R+  QW DQ + +   W      A LF+I N  GQ     MI++R  V + CGIL  IV LQTI YHI W   FL RN+++ G LLLLL E+ E+   + AG+P +G+S +P+ Y+LL GR++++ +F++ ++        ++  +   LI LV++G +TKL A++LV+WLF +N W NA+W+  +D F  D++KYDFFQTMSVIGGLLL++AYGPGGVS+DDYKK 
Sbjct:   10 QNEMLAKAEDAAEDFFRKTRTYLPHIARLCLVSTFLEDGIRMYFQWDDQKQFMQESWSCGWFIATLFVIYNFFGQFIPVLMIMLRKKVLVACGILASIVILQTIAYHILWDLKFLARNIAVGGGLLLLLAETQEEKASLFAGVPTMGDSNKPKSYMLLAGRVLLIFMFMSLMHFEMSFMQVLEIVVGFALITLVSIGYKTKLSAIVLVIWLFGLNLWLNAWWTIPSDRFYRDFMKYDFFQTMSVIGGLLLVIAYGPGGVSVDDYKKR 276
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Celegans
Match: sft-4 (Surfeit locus protein 4 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q18864])

HSP 1 Score: 219.164 bits (557), Expect = 7.548e-69
Identity = 126/267 (47.19%), Postives = 181/267 (67.79%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGES-QPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +NE++ + +D A+   RKTR  LP I R CLV+TF+EDG+R+  QW DQ + +   W      A LF+I N  GQ     MI++R  V + CGIL  IV LQTI YHI W   FL RN+++ G LLLLL E+ E+   + AG+P +G+S +P+ Y+LL GR++++ +F++ ++        ++  +   LI LV++G +TKL A++LV+WLF +N W NA+W+  +D F  D++KYDFFQTMSVIGGLLL++AYGPGGVS+DDYKK 
Sbjct:   10 QNEMLAKAEDAAEDFFRKTRTYLPHIARLCLVSTFLEDGIRMYFQWDDQKQFMQESWSCGWFIATLFVIYNFFGQFIPVLMIMLRKKVLVACGILASIVILQTIAYHILWDLKFLARNIAVGGGLLLLLAETQEEKASLFAGVPTMGDSNKPKSYMLLAGRVLLIFMFMSLMHFEMSFMQVLEIVVGFALITLVSIGYKTKLSAIVLVIWLFGLNLWLNAWWTIPSDRFYRDFMKYDFFQTMSVIGGLLLVIAYGPGGVSVDDYKKR 276
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Celegans
Match: T02E1.7 (pep chromosome:WBcel235:I:8208712:8210703:-1 gene:WBGene00011379.1 transcript:T02E1.7.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T02E1.7)

HSP 1 Score: 115.931 bits (289), Expect = 1.369e-29
Identity = 81/271 (29.89%), Postives = 138/271 (50.92%), Query Frame = 2 
Query:   86 NEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHIWSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMV----GESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLF----IMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKK 874
            N +I R +D  +++ R TR +LPTIGR  L++TF+EDG+RL     D V H    WG    F++   I  I+  + GS  +++RY V     +L   +F Q I Y +++   L+     + + ++LL   N   KP  A    +     E +    LL   R+ + L+ ++ ++        +   I+  +++ V +G +T++ + +L  WLF    ++N ++N              ++YDFFQT+S IGGLLL++  GPG  S D+ KK
Sbjct:    4 NVVITRCEDYTETLARNTRKVLPTIGRLLLISTFVEDGLRLLFNTHDHVNHFSYNWGLNYHFSLFLTIVMIINLLFGSLFVMMRYKVTESSAVLGFTIFAQVILYQLYTTYHLLTRNISIVAAIMLLVAENMLRKPKPANYTQLPRDEHEIEVTSVLLAACRVCLNLMLISMVHFDMSYTRILLCIISYGMMIFVWLGFKTRMMSFMLATWLFAYNIVLNDFWNKDAELHI-------IRYDFFQTLSAIGGLLLLIHTGPGEFSFDELKK 267
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Fly
Match: Surf4 (gene:FBgn0019925 transcript:FBtr0083117)

HSP 1 Score: 209.92 bits (533), Expect = 2.832e-65
Identity = 119/265 (44.91%), Postives = 188/265 (70.94%), Query Frame = 2 
Query:   86 NEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            NE I + +DVA+ V+++ +++LPT+ R CL+ATF EDG+R+  QW++Q E++   WG  K  A +F++ N++GQ+ G  M++ R+ V I  G+L  IV LQT+ Y I W F FL+RN +L+G+LLL+L E+  + + + AG+P +GE++P+ ++ L GR+++  +F+T I     ++  IQ  I  +L++LV +G +TKL A+ILV  L I+N ++NA+W+  +     D+LKYDFFQT+SVIGGLL+IV+ GPGGVSMD++KK 
Sbjct:    5 NEYIAKTEDVAEQVIKRGKNVLPTVARLCLIATFFEDGLRMYIQWNEQREYMDMSWGCGKFLATVFVLVNLLGQLGGCGMVMARFKVDIAVGLLFFIVVLQTVAYSILWDFQFLLRNFALIGALLLVLAEARIEGRSLFAGVPSMGENKPKNFMQLAGRILLAFMFITLIRFELSVWQVIQDIIGSILMVLVVLGYKTKLSALILVALLTILNLYHNAWWTIPSYKPLRDFLKYDFFQTLSVIGGLLMIVSLGPGGVSMDEHKKK 269
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Zebrafish
Match: surf4 (surfeit 4 [Source:NCBI gene;Acc:394102])

HSP 1 Score: 209.534 bits (532), Expect = 4.425e-65
Identity = 127/266 (47.74%), Postives = 178/266 (66.92%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            + +++   +D+AD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W      A  F+I N++GQI G  ++L R  V+  C  L  I+ LQT+ Y I W   FLMRNL+L G LLLLL ES  + K + AG+P +GES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   LI+LVAVG +TKL A+ LVVWL  +N ++NAFW+        D+LKYDFFQT SVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QEDMMSAAEDLADQFLRVTKQYLPHMARLCLISTFLEDGIRMWFQWSEQRDYIEATWSCGYFLATCFVIINLIGQIGGCVLVLSRNLVQYACFGLFCIIALQTVAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPSMGESSPKQYMQLGGRVLLVLMFMTLLHFDSDFFSILQNMVGTALIILVAVGFKTKLAALTLVVWLLAINVYFNAFWTVPAYKPMHDFLKYDFFQTTSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Zebrafish
Match: surf4l (surfeit 4, like [Source:ZFIN;Acc:ZDB-GENE-040718-172])

HSP 1 Score: 209.534 bits (532), Expect = 5.428e-65
Identity = 127/267 (47.57%), Postives = 178/267 (66.67%), Query Frame = 2 
Query:   80 SKNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            + N+++   +DVAD  LR T+  LP I R CL++TF+EDG+R+  QWS+Q E++   W      A LF++ N++GQ+ G  +IL R  V+  C  L  I+ LQT+ Y I W   FLMRNL+L G LLLLL ES  + + + AG+P + ES P+QY+ LGGR+++VL+F+T ++        +Q  +   LI+LVA+G +TKL A+ LV+WL  +N ++NAFW+        D+LKYDFFQT SVIGGLLLIVA GPGGVSMD+ KK 
Sbjct:    2 APNDLMSNAEDVADQFLRVTKQYLPHIARLCLISTFLEDGIRMWFQWSEQKEYIETTWSCGFFLATLFVLINLLGQLGGCILILSRNFVQYACFGLFAIIALQTVAYSILWDPKFLMRNLALGGGLLLLLAESRSEGRSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDTSFLSILQNLVGTALIVLVAIGFKTKLAALTLVIWLLAINVYFNAFWTIPAYKPMHDFLKYDFFQTTSVIGGLLLIVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Xenopus
Match: surf4.2 (surfeit 4, gene 1, gene 2 [Source:NCBI gene;Acc:395004])

HSP 1 Score: 206.453 bits (524), Expect = 1.090e-63
Identity = 125/251 (49.80%), Postives = 173/251 (68.92%), Query Frame = 2 
Query:  128 LRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W      A LF++ N++GQ+    ++L R  V+  C  L GI+ +QTIGY I W   FLMRNL+L G +LLLL ES  + K + AG+P +GES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   LI+LVA+G +TKL A+ LVVWLF MN ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:   22 LRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIEATWSCGYFLAALFVLINLLGQLGCCILVLSRNFVQYACFGLFGIIAMQTIGYSILWDLKFLMRNLALGGGVLLLLAESRSEGKSMFAGVPTMGESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSILQNFVGTALIILVAIGFKTKLAALTLVVWLFAMNVYFNAFWTIPAYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 272
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Xenopus
Match: surf4.1 (surfeit 4, gene 1 [Source:NCBI gene;Acc:493450])

HSP 1 Score: 199.904 bits (507), Expect = 3.773e-61
Identity = 126/258 (48.84%), Postives = 179/258 (69.38%), Query Frame = 2 
Query:  107 DDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +++AD  LR T+  LP I   CL++TF+EDG+R+  QW++Q E+++  W      A LF+I N+ GQ+AG  ++L R  V   C  L+GI+ LQT+ Y+I W   FLMRN++LVG LLLLL ES  + K + AG+P +G + PRQY+ LGGR++++L+F+T ++ +   F   Q    L LILLVAVG +TKL A+ LV+WL ++N   NAFW+  +     D+LKYDFFQT+SV+GGLLL+VA GPGGVSMD++KK 
Sbjct:    5 EELADQFLRVTKRYLPHIAHLCLISTFLEDGLRMWLQWNEQREYINMSWNCGMHLATLFVIFNLCGQLAGCVLVLTRKFVPYACFGLLGIIILQTVVYNILWDAKFLMRNMALVGGLLLLLAESRSEGKSMFAGVPNMGGTSPRQYMQLGGRVLLILMFMTLLHFNASPFTIFQDIFGLALILLVAVGFKTKLAALTLVLWLLVINVVQNAFWTVPSYRPLHDFLKYDFFQTLSVMGGLLLVVALGPGGVSMDEHKKK 262
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Xenopus
Match: surf4.1 (surfeit 4, gene 1 [Source:NCBI gene;Acc:493450])

HSP 1 Score: 199.519 bits (506), Expect = 4.617e-61
Identity = 126/267 (47.19%), Postives = 182/267 (68.16%), Query Frame = 2 
Query:   80 SKNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +   ++   +++AD  LR T+  LP I   CL++TF+EDG+R+  QW++Q E+++  W      A LF+I N+ GQ+AG  ++L R  V   C  L+GI+ LQT+ Y+I W   FLMRN++LVG LLLLL ES  + K + AG+P +G + PRQY+ LGGR++++L+F+T ++ +   F   Q    L LILLVAVG +TKL A+ LV+WL ++N   NAFW+  +     D+LKYDFFQT+SV+GGLLL+VA GPGGVSMD++KK 
Sbjct:    2 APGNVMGAAEELADQFLRVTKRYLPHIAHLCLISTFLEDGLRMWLQWNEQREYINMSWNCGMHLATLFVIFNLCGQLAGCVLVLTRKFVPYACFGLLGIIILQTVVYNILWDAKFLMRNMALVGGLLLLLAESRSEGKSMFAGVPNMGGTSPRQYMQLGGRVLLILMFMTLLHFNASPFTIFQDIFGLALILLVAVGFKTKLAALTLVLWLLVINVVQNAFWTVPSYRPLHDFLKYDFFQTLSVMGGLLLVVALGPGGVSMDEHKKK 268
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Xenopus
Match: surf4.1 (surfeit 4, gene 1 [Source:NCBI gene;Acc:493450])

HSP 1 Score: 194.897 bits (494), Expect = 3.017e-59
Identity = 125/254 (49.21%), Postives = 175/254 (68.90%), Query Frame = 2 
Query:  119 DSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            D  LR T+  LP I   CL++TF+EDG+R+  QW++Q E+++  W      A LF+I N+ GQ+AG  ++L R  V   C  L+GI+ LQT+ Y+I W   FLMRN++LVG LLLLL ES  + K + AG+P +G + PRQY+ LGGR++++L+F+T ++ +   F   Q    L LILLVAVG +TKL A+ LV+WL ++N   NAFW+  +     D+LKYDFFQT+SV+GGLLL+VA GPGGVSMD++KK 
Sbjct:   10 DMFLRVTKRYLPHIAHLCLISTFLEDGLRMWLQWNEQREYINMSWNCGMHLATLFVIFNLCGQLAGCVLVLTRKFVPYACFGLLGIIILQTVVYNILWDAKFLMRNMALVGGLLLLLAESRSEGKSMFAGVPNMGGTSPRQYMQLGGRVLLILMFMTLLHFNASPFTIFQDIFGLALILLVAVGFKTKLAALTLVLWLLVINVVQNAFWTVPSYRPLHDFLKYDFFQTLSVMGGLLLVVALGPGGVSMDEHKKK 263
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Xenopus
Match: surf4.2 (surfeit 4, gene 1, gene 2 [Source:NCBI gene;Acc:395004])

HSP 1 Score: 149.443 bits (376), Expect = 8.287e-42
Identity = 100/186 (53.76%), Postives = 132/186 (70.97%), Query Frame = 2 
Query:  323 MILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            ++L R  V+  C  L GI+ +QTIGY I W   FLMRNL+L G +LLLL ES  + K + AG+P +GES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   LI+LVA+G +TKL A+ LVVWLF MN ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:   81 LVLSRNFVQYACFGLFGIIAMQTIGYSILWDLKFLMRNLALGGGVLLLLAESRSEGKSMFAGVPTMGESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSILQNFVGTALIILVAIGFKTKLAALTLVVWLFAMNVYFNAFWTIPAYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 266
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Mouse
Match: Surf4 (surfeit gene 4 [Source:MGI Symbol;Acc:MGI:98445])

HSP 1 Score: 213.772 bits (543), Expect = 1.360e-66
Identity = 128/266 (48.12%), Postives = 180/266 (67.67%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +N+++   +D AD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     F  IQ  +   L++LVA+G +TKL A+ LVVWLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWSCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIIQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Mouse
Match: Surf4 (surfeit gene 4 [Source:MGI Symbol;Acc:MGI:98445])

HSP 1 Score: 81.6481 bits (200), Expect = 2.050e-18
Identity = 38/93 (40.86%), Postives = 58/93 (62.37%), Query Frame = 2 
Query:  128 LRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI 406
            LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I
Sbjct:   29 LRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWSCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSI 121
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Mouse
Match: Surf4 (surfeit gene 4 [Source:MGI Symbol;Acc:MGI:98445])

HSP 1 Score: 69.707 bits (169), Expect = 1.334e-14
Identity = 28/76 (36.84%), Postives = 49/76 (64.47%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQI 310
            +N+++   +D AD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W    + A  F+  N++GQ+
Sbjct:    3 QNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWSCGYLLASSFVFLNLLGQL 78
[Close]
BLAST of Surfeit locus protein 4 vs. UniProt/SwissProt
Match: sp|Q18864|SURF4_CAEEL (Surfeit locus protein 4 homolog OS=Caenorhabditis elegans OX=6239 GN=sft-4 PE=2 SV=1)

HSP 1 Score: 219.164 bits (557), Expect = 9.602e-68
Identity = 126/267 (47.19%), Postives = 181/267 (67.79%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGES-QPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +NE++ + +D A+   RKTR  LP I R CLV+TF+EDG+R+  QW DQ + +   W      A LF+I N  GQ     MI++R  V + CGIL  IV LQTI YHI W   FL RN+++ G LLLLL E+ E+   + AG+P +G+S +P+ Y+LL GR++++ +F++ ++        ++  +   LI LV++G +TKL A++LV+WLF +N W NA+W+  +D F  D++KYDFFQTMSVIGGLLL++AYGPGGVS+DDYKK 
Sbjct:   10 QNEMLAKAEDAAEDFFRKTRTYLPHIARLCLVSTFLEDGIRMYFQWDDQKQFMQESWSCGWFIATLFVIYNFFGQFIPVLMIMLRKKVLVACGILASIVILQTIAYHILWDLKFLARNIAVGGGLLLLLAETQEEKASLFAGVPTMGDSNKPKSYMLLAGRVLLIFMFMSLMHFEMSFMQVLEIVVGFALITLVSIGYKTKLSAIVLVIWLFGLNLWLNAWWTIPSDRFYRDFMKYDFFQTMSVIGGLLLVIAYGPGGVSVDDYKKR 276
[Close]
BLAST of Surfeit locus protein 4 vs. UniProt/SwissProt
Match: sp|Q800K9|SURF4_CHICK (Surfeit locus protein 4 OS=Gallus gallus OX=9031 GN=SURF4 PE=2 SV=1)

HSP 1 Score: 214.542 bits (545), Expect = 4.990e-66
Identity = 129/266 (48.50%), Postives = 181/266 (68.05%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +N+I+   +D AD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W      A +F+  N+ GQ++G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     FY +Q  +   LI+LVA+G +TKL A+ LV+WLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QNDIMSTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDGTWNCGYFLASIFVFINLFGQLSGCILVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDMNFFYILQNIVGTALIILVAIGFKTKLAALTLVIWLFGINIYFNAFWTIPAYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. UniProt/SwissProt
Match: sp|Q64310|SURF4_MOUSE (Surfeit locus protein 4 OS=Mus musculus OX=10090 GN=Surf4 PE=1 SV=1)

HSP 1 Score: 213.772 bits (543), Expect = 9.514e-66
Identity = 128/266 (48.12%), Postives = 180/266 (67.67%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +N+++   +D AD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     F  IQ  +   L++LVA+G +TKL A+ LVVWLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWSCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIIQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. UniProt/SwissProt
Match: sp|Q5R705|SURF4_PONAB (Surfeit locus protein 4 OS=Pongo abelii OX=9601 GN=SURF4 PE=2 SV=1)

HSP 1 Score: 213.772 bits (543), Expect = 1.015e-65
Identity = 127/266 (47.74%), Postives = 180/266 (67.67%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +N+++   +D AD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   L++LVA+G +TKL A+ LVVWLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. UniProt/SwissProt
Match: sp|O15260|SURF4_HUMAN (Surfeit locus protein 4 OS=Homo sapiens OX=9606 GN=SURF4 PE=1 SV=3)

HSP 1 Score: 213.772 bits (543), Expect = 1.015e-65
Identity = 127/266 (47.74%), Postives = 180/266 (67.67%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +N+++   +D AD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q +++   W    + A  F+  N++GQ+ G  ++L R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P + ES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   L++LVA+G +TKL A+ LVVWLF +N ++NAFW+        D+LKYDFFQTMSVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. TrEMBL
Match: A0A5K3EXS2 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 273.092 bits (697), Expect = 2.657e-86
Identity = 164/269 (60.97%), Postives = 214/269 (79.55%), Query Frame = 2 
Query:   74 KKSKNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHIWSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVG-ESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
              S++EII +L+DVAD V+R++RH LP + R CLV+TFIEDG RL +QWS+QVE + ++W T    A LF++ NI+ Q AGSA +++RY VK+GCGIL+  V +QTIGY+IW+ IFLMRNLSLVGSLLLL+ E+ ++ + ++AGLP VG E++ RQYL LGGRL+VVL+FLT ++  G  FY IQ+ +NL+LILLVA+G +TKLCA+ILV WL  MN +YN FWS+  D   WD+LKYDFFQT SVIGGL+LIVA+GPGGVS+DDYKK 
Sbjct:    8 SSSRDEIISKLEDVADRVVRRSRHYLPHVARLCLVSTFIEDGFRLLTQWSEQVEFIRHVWSTGSFIAGLFILINILMQFAGSAFVMVRYKVKVGCGILLATVVIQTIGYNIWTRIFLMRNLSLVGSLLLLIAEAGQQSRSLLAGLPSVGDENRSRQYLQLGGRLLVVLMFLTLVHWGGSFFYLIQSILNLILILLVAIGYKTKLCALILVSWLTCMNFYYNDFWSNYNDEIMWDFLKYDFFQTWSVIGGLMLIVAHGPGGVSVDDYKKE 276
[Close]
BLAST of Surfeit locus protein 4 vs. TrEMBL
Match: G4M133 (Surfeit locus protein, putative OS=Schistosoma mansoni OX=6183 GN=Smp_174450 PE=4 SV=1)

HSP 1 Score: 266.929 bits (681), Expect = 6.622e-84
Identity = 163/274 (59.49%), Postives = 212/274 (77.37%), Query Frame = 2 
Query:   59 VAIMDKKSKN-EIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHIWSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            V IM + S + E+++RL+D AD ++RK+R  LP I RFCLV+TFIEDG RL +QWSDQV+++  +WGT  IFA  F++ NI  Q  GSA++L RY VKIG GILM  V +QTIGY+IW+ +F MRNLSL+GSLLLLL E  ++ + ++AGLP  GE+  RQY+LLGGR++++L+F+T I+    IFY IQ+  NL+LILLVA+G +TKLCA +LV+WL  MN +YN FW+ S DS  WD+LKYDFFQT SVIGGL L+VAYGPGGVS+DDYKK 
Sbjct:    2 VDIMQRSSTSRELLDRLEDHADWLVRKSRRYLPHIARFCLVSTFIEDGFRLLTQWSDQVDYIQGVWGTHVIFAAFFILLNICLQFTGSALVLGRYRVKIGVGILMSTVLIQTIGYNIWTKVFFMRNLSLIGSLLLLLAEVQQETRSLLAGLPSSGENTHRQYILLGGRILIILMFVTLIHLGSSIFYVIQSIGNLILILLVAIGYKTKLCATVLVIWLTGMNFYYNRFWAVSNDSLMWDFLKYDFFQTWSVIGGLGLVVAYGPGGVSVDDYKKK 275
[Close]
BLAST of Surfeit locus protein 4 vs. TrEMBL
Match: A0A183QVE2 (Uncharacterized protein OS=Schistosoma rodhaini OX=6188 PE=4 SV=1)

HSP 1 Score: 266.929 bits (681), Expect = 7.301e-84
Identity = 163/274 (59.49%), Postives = 212/274 (77.37%), Query Frame = 2 
Query:   59 VAIMDKKSKN-EIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHIWSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            V IM + S + E+++RL+D AD ++RK+R  LP I RFCLV+TFIEDG RL +QWSDQV+++  +WGT  IFA  F++ NI  Q  GSA++L RY VKIG GILM  V +QTIGY+IW+ +F MRNLSL+GSLLLLL E  ++ + ++AGLP  GE+  RQY+LLGGR++++L+F+T I+    IFY IQ+  NL+LILLVA+G +TKLCA +LV+WL  MN +YN FW+ S DS  WD+LKYDFFQT SVIGGL L+VAYGPGGVS+DDYKK 
Sbjct:    2 VDIMQRSSTSRELLDRLEDHADWLIRKSRRYLPHIARFCLVSTFIEDGFRLLTQWSDQVDYIQGVWGTHVIFAAFFILLNICLQFTGSALVLGRYRVKIGVGILMSTVLIQTIGYNIWTKVFFMRNLSLIGSLLLLLAEVQQETRSLLAGLPSSGENAHRQYILLGGRILIILMFVTLIHLGSSIFYVIQSIGNLILILLVAIGYKTKLCATVLVIWLTGMNFYYNRFWAVSNDSLMWDFLKYDFFQTWSVIGGLGLVVAYGPGGVSVDDYKKK 275
[Close]
BLAST of Surfeit locus protein 4 vs. TrEMBL
Match: A0A0X3P4Q4 (Surfeit locus protein 4 OS=Schistocephalus solidus OX=70667 GN=SURF4 PE=4 SV=1)

HSP 1 Score: 266.159 bits (679), Expect = 1.325e-83
Identity = 156/273 (57.14%), Postives = 209/273 (76.56%), Query Frame = 2 
Query:   59 VAIMDKKSKNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHIWSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +A +  +  N+I+ R DD AD+ +R++R  LP + RFCLV+TFIEDG RL +QWSDQ++ + ++WG+    A +F++ NI+ Q AGSA +L RY VK+GCGILM  V LQTIGY+IW+ IFLMRNLSL+GSLLLL+ E++++ + ++AGLP  G +  RQYL LGGR++VVL+F+T I+  G  FY IQAA +L LILLVA+G + KLC+++LV WL  +N +YN FW +  D   WD+LKYDFFQT SVIGGLLLIVA+GPGGVS+DDYKK 
Sbjct:    1 MASLFSRDYNDILSRFDDAADTFVRRSRRYLPHVARFCLVSTFIEDGFRLLTQWSDQIDFIKHIWGSVGFLAGIFILVNIILQFAGSAFVLTRYRVKVGCGILMCTVILQTIGYNIWTRIFLMRNLSLMGSLLLLIAEASQESRSLLAGLPSAGGNASRQYLQLGGRILVVLMFVTLIHWDGSFFYLIQAAAHLALILLVAIGYKAKLCSIVLVAWLSCINMYYNCFWRAYDDEIMWDFLKYDFFQTWSVIGGLLLIVAHGPGGVSVDDYKKE 273
[Close]
BLAST of Surfeit locus protein 4 vs. TrEMBL
Match: A0A095C2W5 (Surfeit locus protein 4-like protein OS=Schistosoma haematobium OX=6185 GN=MS3_04308 PE=4 SV=1)

HSP 1 Score: 265.774 bits (678), Expect = 1.413e-83
Identity = 163/271 (60.15%), Postives = 210/271 (77.49%), Query Frame = 2 
Query:   68 MDKKSKN-EIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHIWSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            M + S N E+++RL+D AD ++RK+R  LP I RFCLV+TFIEDG RL +QWSDQV+++ ++WGT  IFA  F++ NI  Q  GSA +L RY VKIG GILM  V LQTIGY+IW+ +F MRNLSL+GSLLLLL E  ++ + ++AGLP  GE+  RQY+LLGGR++++L+F+T I+    IFY IQ+  NL+LILLVA+G +TKLCA +LV+WL  MN +YN FW+ S DS  WD+LKYDFFQT SVIGGL L+VAYGPGGVS+DDYKK 
Sbjct:    1 MQRGSTNRELLDRLEDHADWLVRKSRRYLPHIARFCLVSTFIEDGFRLLTQWSDQVDYIQSVWGTHVIFAAFFILLNICLQFIGSAFVLGRYRVKIGVGILMSTVLLQTIGYNIWTKVFFMRNLSLIGSLLLLLAEVQQETRSLLAGLPSSGENTHRQYILLGGRILIILMFVTLIHLGSSIFYVIQSISNLILILLVAIGYKTKLCATVLVIWLTGMNFYYNRFWAVSNDSLMWDFLKYDFFQTWSVIGGLGLVVAYGPGGVSVDDYKKK 271
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Cavefish
Match: surf4l (surfeit locus protein 4 [Source:NCBI gene;Acc:103043297])

HSP 1 Score: 213.772 bits (543), Expect = 1.127e-66
Identity = 132/266 (49.62%), Postives = 182/266 (68.42%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +N ++   +DVAD  LR T+  LP + R CL++TF+EDG+R+  QWS+Q E++ + WG     A LF++ N++GQ+ G  +IL R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + + + AG+P + ES P+QY+ LGGR+++VL+F+T ++        +Q  +   LI+LVA+G +TKL A+ LVVWLFI+N  +NAFW+  T     D+LKYDFFQT SVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QNSLMSTAEDVADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQKEYIESSWGCGFFLASLFVLINLLGQLGGCILILSRNFVQYACFGLFGIIGLQTIAYSILWDPKFLMRNLALGGGLLLLLAESKSEGRSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDANFLSILQNLVGTALIILVAIGFKTKLAALTLVVWLFIINVSFNAFWNIPTYKPMHDFLKYDFFQTTSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Cavefish
Match: surf4 (surfeit 4 [Source:NCBI gene;Acc:103029299])

HSP 1 Score: 198.364 bits (503), Expect = 8.832e-61
Identity = 124/266 (46.62%), Postives = 179/266 (67.29%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            + +++   +DVAD  LR T+  LP + R CL++TF+EDG+R+  QW++Q +++   W      A  F++ N++GQ+ G  +IL R  V+  C  L GI+ LQT+ Y I W   FLMRN++L G LLLLL ES  + K + AG+P +GES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   LI+LVA+G +TKL A+ LVVWL  +N ++NAFW+        D+LKYDFFQT SV+GGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QEDLMSTAEDVADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWNEQRDYIEATWSCGYFLATCFVLLNLLGQLGGCVLILSRNFVQYACFGLFGIIALQTVAYSILWDLKFLMRNMALGGGLLLLLAESRSEGKSMFAGVPSMGESSPKQYMQLGGRVLLVLMFMTLLHFDSSFFSILQNMVGTALIILVAIGFKTKLAALTLVVWLMAINVYFNAFWTVPAYKPMHDFLKYDFFQTTSVVGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Cavefish
Match: surf4 (surfeit 4 [Source:NCBI gene;Acc:103029299])

HSP 1 Score: 190.66 bits (483), Expect = 6.422e-58
Identity = 123/258 (47.67%), Postives = 173/258 (67.05%), Query Frame = 2 
Query:  107 DDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            D VA   LR T+  LP + R CL++TF+EDG+R+  QW++Q +++   W      A  F++ N++GQ+ G  +IL R  V+  C  L GI+ LQT+ Y I W   FLMRN++L G LLLLL ES  + K + AG+P +GES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   LI+LVA+G +TKL A+ LVVWL  +N ++NAFW+        D+LKYDFFQT SV+GGLLL+VA GPGGVSMD+ KK 
Sbjct:    5 DLVASRFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWNEQRDYIEATWSCGYFLATCFVLLNLLGQLGGCVLILSRNFVQYACFGLFGIIALQTVAYSILWDLKFLMRNMALGGGLLLLLAESRSEGKSMFAGVPSMGESSPKQYMQLGGRVLLVLMFMTLLHFDSSFFSILQNMVGTALIILVAIGFKTKLAALTLVVWLMAINVYFNAFWTVPAYKPMHDFLKYDFFQTTSVVGGLLLVVALGPGGVSMDEKKKE 262
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Sea Lamprey
Match: surf4l (surfeit 4, like [Source:ZFIN;Acc:ZDB-GENE-040718-172])

HSP 1 Score: 135.961 bits (341), Expect = 1.501e-38
Identity = 79/180 (43.89%), Postives = 118/180 (65.56%), Query Frame = 2 
Query:   77 KSKNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIF 613
            +   +++ R +DVAD  LR T+H LP + R CLV+TF+EDGVR+  QWS Q +++  +WG   + A LF+  N+VGQ++G  ++L R  V   C  L  I+ LQT+ Y+I W   FLMRNL+L G LLLLL E+    + + AG+P +GE+ P+QY+ LGGR+++ L+F+T +N     F
Sbjct:    2 QGNTDVMSRAEDVADQFLRVTKHYLPHLARLCLVSTFLEDGVRMWFQWSLQRDYIDRMWGAGFVLASLFVFINLVGQLSGCVLVLSRNFVSYACYGLFVIIALQTLAYNILWDAHFLMRNLALGGGLLLLLAENRSDGRSMFAGVPTMGENSPKQYMQLGGRVLLTLMFMTLLNFEASFF 181
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Yeast
Match: ERV29 (Protein localized to COPII-coated vesicles; involved in vesicle formation and incorporation of specific secretory cargo; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000003516])

HSP 1 Score: 91.6633 bits (226), Expect = 2.372e-21
Identity = 83/272 (30.51%), Postives = 150/272 (55.15%), Query Frame = 2 
Query:   74 KKSKNEIIERLDDVAD-SVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFK-IFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHIWS-FIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGE--SQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKK 874
            K S  +   R++ + D +V+ K +  +P++ RF +VATF ED  R+ SQWSDQ+ +L N W  +   F ++FL+   V  + G++++++R       G+L   V  Q + Y +++   F++RN S++G LL+   +S  + K     LP +     + + YLL  GR+++VL+F+    S      +    + ++  +  A+G +TK  +++L + L   N   N       ++   D+LKY+F+Q +S+IGGLLL+   G G +S+D+ KK
Sbjct:   44 KHSFEKFASRIEGLTDNAVVYKLKPYIPSLSRFFIVATFYEDSFRILSQWSDQIFYL-NKWKHYPYFFVVVFLVVVTVSMLIGASLLVLRKQTNYATGVLCACVISQALVYGLFTGSSFVLRNFSVIGGLLIAFSDSIVQNKTTFGMLPELNSKNDKAKGYLLFAGRILIVLMFIAFTFSKS----WFTVVLTIIGTICFAIGYKTKFASIMLGLILTFYNITLN--NYWFYNNTKRDFLKYEFYQNLSIIGGLLLVTNTGAGELSVDEKKK 308
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BLAST of Surfeit locus protein 4 vs. Ensembl Nematostella
Match: EDO44233 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RWB5])

HSP 1 Score: 196.823 bits (499), Expect = 1.535e-60
Identity = 123/265 (46.42%), Postives = 178/265 (67.17%), Query Frame = 2 
Query:   86 NEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            +E + + +D+AD +LR  +H+LP + RFCL++TF EDG+R+  QW +Q +++   W    + ++LF+I N++ Q+ G  MIL R  V    GIL  +V LQTIGY I W F FL+RNL+L G LLL+L +S  + K + AG+P VG + P+ YL L GR+++V +F T I       Y +      +L++LVA+G +TKL +++LV+ L ++N   N FW   ++S   D+LKYDFFQTMSVIGGLLL+VA GPGGVS+DDYKK 
Sbjct:   10 SEFMHKAEDLADQILRNGKHVLPHVARFCLISTFFEDGIRMWFQWGEQRDYIDQTWHCGTVLSVLFVIYNLLAQLGGCLMILSRQKVDYAVGILASVVLLQTIGYSILWDFKFLLRNLALCGGLLLILADSRSEQKSLFAGVPSVGGNTPKTYLQLTGRVLLVFMFATLIRFQLSFSYLLLDIAGTILMVLVAIGYKTKLASLVLVILLSVLNIVLNPFWVFDSNSPMRDFLKYDFFQTMSVIGGLLLVVALGPGGVSVDDYKKK 274
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Medaka
Match: surf4 (surfeit 4 [Source:NCBI gene;Acc:101158292])

HSP 1 Score: 212.231 bits (539), Expect = 3.696e-66
Identity = 127/266 (47.74%), Postives = 179/266 (67.29%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHI-WSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            + + + + +DVAD  LR T+  LP + R CL++TF+EDG+R+  QW++Q +++   W      A  F++ N++GQ+ G  +IL R  V+  C  L GI+ LQTI Y I W   FLMRNL+L G LLLLL ES  + K + AG+P +GES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   LI+LVA+G +TKL A+ LVVWL  +N ++NAFW+        D+LKYDFFQT SVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QEDFMNKAEDVADQFLRVTKQYLPHLARLCLISTFLEDGIRMWFQWNEQRDYIEATWNCGYFLATCFVLLNLIGQLGGCVLILSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPSMGESSPKQYMQLGGRVLLVLMFMTLLHFDSSFFSILQNIVGTALIILVAIGFKTKLAALTLVVWLMAINVYFNAFWTIPAYKPMHDFLKYDFFQTTSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. Ensembl Medaka
Match: surf4 (surfeit 4 [Source:NCBI gene;Acc:101158292])

HSP 1 Score: 190.274 bits (482), Expect = 1.156e-57
Identity = 116/266 (43.61%), Postives = 173/266 (65.04%), Query Frame = 2 
Query:   83 KNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHIWSFIFLMRNXXXXXX-XXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            + + + + +DVAD  LR T+  LP + R CL++TF+EDG+R+  QW++Q +++   W      A  F++ N++GQ+ G  +IL R  V+  C  L GI+ LQ        +++   N+++V   LLLLL ES  + K + AG+P +GES P+QY+ LGGR+++VL+F+T ++     F  +Q  +   LI+LVA+G +TKL A+ LVVWL  +N ++NAFW+        D+LKYDFFQT SVIGGLLL+VA GPGGVSMD+ KK 
Sbjct:    3 QEDFMNKAEDVADQFLRVTKQYLPHLARLCLISTFLEDGIRMWFQWNEQRDYIEATWNCGYFLATCFVLLNLIGQLGGCVLILSRNFVQYACFGLFGIIALQVNNTFFRLYLYFPFNITIVTCGLLLLLAESRSEGKSMFAGVPSMGESSPKQYMQLGGRVLLVLMFMTLLHFDSSFFSILQNIVGTALIILVAIGFKTKLAALTLVVWLMAINVYFNAFWTIPAYKPMHDFLKYDFFQTTSVIGGLLLVVALGPGGVSMDEKKKE 268
[Close]
BLAST of Surfeit locus protein 4 vs. Planmine SMEST
Match: SMESG000041256.1 (SMESG000041256.1)

HSP 1 Score: 246.514 bits (628), Expect = 1.283e-79
Identity = 162/268 (60.45%), Postives = 201/268 (75.00%), Query Frame = 2 
Query:   74 KKSKNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQWSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGILMGIVFLQTIGYHIWSFIFLMRNXXXXXXXXXXXXESNEKIKPIMAGLPMVGESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFXXXXXXXXXXXXXXXXXRTKLCAMILVVWLFIMNCWYNAXXXXXXXXXXXXYLKYDFFQTMSVIGGLLLIVAYGPGGVSMDDYKKN 877
            + +K + +  L++ AD V+RKTR  LP I R CLV+TFIEDG RL +QWSDQ++ + +LW         FL+ NI+ Q+ GSA+I+ RY V  GC ILM  V LQTIGY I + +F+MRNL+L+GSLLLLL ESNEK+K  +AGLP  G +QP+QY+LLGGRL+VVLIF+T I+  GG FY IQ   NLVLI++VA+GL+TKLCA+ILV WL  MN WYN FW        WD+LKYDFFQT SVIGGLLLIVAYGPGGVS+DDYKK+
Sbjct:    6 RNNKKDCLSNLENYADIVIRKTRRFLPHIARVCLVSTFIEDGYRLITQWSDQIDFISSLWKMNSFIIGFFLLINIICQLMGSALIICRYRVNSGCAILMFDVILQTIGYGITNKVFIMRNLALIGSLLLLLAESNEKVKSYLAGLPSTGINQPKQYMLLGGRLLVVLIFITLIHWDGGFFYLIQTLANLVLIIMVAIGLKTKLCAIILVFWLTTMNFWYNNFWYYIDRELLWDFLKYDFFQTWSVIGGLLLIVAYGPGGVSIDDYKKD 273
The following BLAST results are available for this feature:
BLAST of Surfeit locus protein 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SURF42.113e-6647.74surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476][more]
SURF42.113e-6647.74surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476][more]
SURF41.188e-4949.10surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476][more]
SURF41.188e-4949.10surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476][more]
SURF41.188e-4949.10surfeit 4 [Source:HGNC Symbol;Acc:HGNC:11476][more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
sft-47.548e-6947.19Surfeit locus protein 4 homolog [Source:UniProtKB... [more]
sft-47.548e-6947.19Surfeit locus protein 4 homolog [Source:UniProtKB... [more]
T02E1.71.369e-2929.89pep chromosome:WBcel235:I:8208712:8210703:-1 gene:... [more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Surf42.832e-6544.91gene:FBgn0019925 transcript:FBtr0083117[more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
surf44.425e-6547.74surfeit 4 [Source:NCBI gene;Acc:394102][more]
surf4l5.428e-6547.57surfeit 4, like [Source:ZFIN;Acc:ZDB-GENE-040718-1... [more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
surf4.21.090e-6349.80surfeit 4, gene 1, gene 2 [Source:NCBI gene;Acc:39... [more]
surf4.13.773e-6148.84surfeit 4, gene 1 [Source:NCBI gene;Acc:493450][more]
surf4.14.617e-6147.19surfeit 4, gene 1 [Source:NCBI gene;Acc:493450][more]
surf4.13.017e-5949.21surfeit 4, gene 1 [Source:NCBI gene;Acc:493450][more]
surf4.28.287e-4253.76surfeit 4, gene 1, gene 2 [Source:NCBI gene;Acc:39... [more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Surf41.360e-6648.12surfeit gene 4 [Source:MGI Symbol;Acc:MGI:98445][more]
Surf42.050e-1840.86surfeit gene 4 [Source:MGI Symbol;Acc:MGI:98445][more]
Surf41.334e-1436.84surfeit gene 4 [Source:MGI Symbol;Acc:MGI:98445][more]
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BLAST of Surfeit locus protein 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q18864|SURF4_CAEEL9.602e-6847.19Surfeit locus protein 4 homolog OS=Caenorhabditis ... [more]
sp|Q800K9|SURF4_CHICK4.990e-6648.50Surfeit locus protein 4 OS=Gallus gallus OX=9031 G... [more]
sp|Q64310|SURF4_MOUSE9.514e-6648.12Surfeit locus protein 4 OS=Mus musculus OX=10090 G... [more]
sp|Q5R705|SURF4_PONAB1.015e-6547.74Surfeit locus protein 4 OS=Pongo abelii OX=9601 GN... [more]
sp|O15260|SURF4_HUMAN1.015e-6547.74Surfeit locus protein 4 OS=Homo sapiens OX=9606 GN... [more]
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BLAST of Surfeit locus protein 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5K3EXS22.657e-8660.97Uncharacterized protein OS=Mesocestoides corti OX=... [more]
G4M1336.622e-8459.49Surfeit locus protein, putative OS=Schistosoma man... [more]
A0A183QVE27.301e-8459.49Uncharacterized protein OS=Schistosoma rodhaini OX... [more]
A0A0X3P4Q41.325e-8357.14Surfeit locus protein 4 OS=Schistocephalus solidus... [more]
A0A095C2W51.413e-8360.15Surfeit locus protein 4-like protein OS=Schistosom... [more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
surf4l1.127e-6649.62surfeit locus protein 4 [Source:NCBI gene;Acc:1030... [more]
surf48.832e-6146.62surfeit 4 [Source:NCBI gene;Acc:103029299][more]
surf46.422e-5847.67surfeit 4 [Source:NCBI gene;Acc:103029299][more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
surf4l1.501e-3843.89surfeit 4, like [Source:ZFIN;Acc:ZDB-GENE-040718-1... [more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
ERV292.372e-2130.51Protein localized to COPII-coated vesicles; involv... [more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO442331.535e-6046.42Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Surfeit locus protein 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
surf43.696e-6647.74surfeit 4 [Source:NCBI gene;Acc:101158292][more]
surf41.156e-5743.61surfeit 4 [Source:NCBI gene;Acc:101158292][more]
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BLAST of Surfeit locus protein 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000041256.11.283e-7960.45SMESG000041256.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30030329 ID=SMED30030329|Name=Surfeit locus protein 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1201bp
ACATCATTTTTCTCTTTAAAACTACAATTTTACAAAGTCATTGTAAGTTG
AATGCTACGTTGCAATTATGGATAAAAAATCTAAGAATGAAATAATCGAA
AGATTAGATGATGTTGCTGATTCCGTTTTGCGAAAAACTCGACATTTATT
ACCTACAATTGGTAGATTTTGCTTAGTTGCCACGTTTATTGAAGATGGAG
TTAGACTATGTTCACAATGGTCAGATCAAGTGGAACATTTACATAATTTA
TGGGGCACCTTCAAAATATTTGCAATATTATTTTTAATTGCAAATATAGT
AGGACAAATCGCTGGTAGTGCGATGATTTTAATTCGATACAACGTTAAAA
TTGGATGCGGTATTTTAATGGGGATTGTGTTTTTACAAACTATTGGTTAT
CATATTTGGAGTTTTATATTTTTAATGCGTAACCTGTCTTTAGTTGGAAG
CTTATTGTTATTACTTGGTGAAAGTAATGAAAAAATCAAACCTATAATGG
CAGGATTACCAATGGTTGGAGAAAGTCAACCCAGACAATATTTATTGCTA
GGTGGTCGTTTAATGGTTGTTTTAATATTTTTAACGCAAATAAATTCCAG
TGGAGGAATTTTTTATTTCATTCAAGCTGCTATAAACCTCGTATTAATTC
TATTGGTTGCGGTGGGATTGCGAACGAAACTCTGCGCAATGATTCTCGTT
GTCTGGTTATTTATCATGAACTGCTGGTATAATGCTTTTTGGTCTTCGTC
CACGGATTCATTTGATTGGGATTACTTGAAATATGATTTCTTCCAAACCA
TGTCAGTGATTGGTGGCCTACTACTGATAGTTGCCTATGGGCCAGGTGGA
GTTTCGATGGATGATTACAAGAAAAATCGCTAGATATTCGTGATAAATGT
AAATAAAAATTCTCCCTCGGCTTCTTGTTTCTGATTTTCATGTAGAATAT
CGATGACATTTTTTGTGATTTGAGTACAGATGGAAAACTTTGTCGACCGT
GCCTTTTGTCAGTATGGATTTTCAGCAACAAAATGGGCGTTTTAGTTCAT
TTTATTTAGAATTTTAAACTTGCTAAATGTTTTTTCTATTATATATATAT
ATATTTGTCATAATCGATTAGTTGGACAATATTTGACGAATTATGAAGAT
TTAGAAAATTGTATTTTTGTGTTATTAAATATTTGTTTTTTTAAAAAAAA
A
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protein sequence of SMED30030329-orf-1

>SMED30030329-orf-1 ID=SMED30030329-orf-1|Name=SMED30030329-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=272bp
MDKKSKNEIIERLDDVADSVLRKTRHLLPTIGRFCLVATFIEDGVRLCSQ
WSDQVEHLHNLWGTFKIFAILFLIANIVGQIAGSAMILIRYNVKIGCGIL
MGIVFLQTIGYHIWSFIFLMRNLSLVGSLLLLLGESNEKIKPIMAGLPMV
GESQPRQYLLLGGRLMVVLIFLTQINSSGGIFYFIQAAINLVLILLVAVG
LRTKLCAMILVVWLFIMNCWYNAFWSSSTDSFDWDYLKYDFFQTMSVIGG
LLLIVAYGPGGVSMDDYKKNR*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0002032epidermal cell
Vocabulary: INTERPRO
TermDefinition
IPR002995Surf4
Vocabulary: cellular component
TermDefinition
GO:0016021integral component of membrane
GO:0016020membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002995Surfeit locus 4PFAMPF02077SURF4coord: 7..270
e-value: 3.3E-90
score: 302.3
IPR002995Surfeit locus 4PROSITEPS01339SURF4coord: 238..252
NoneNo IPR availablePANTHERPTHR23427SURFEIT LOCUS PROTEINcoord: 6..270
NoneNo IPR availablePANTHERPTHR23427:SF1SURF4L PROTEIN-RELATEDcoord: 6..270
NoneNo IPR availableTMHMMTMhelixcoord: 67..89
NoneNo IPR availableTMHMMTMhelixcoord: 96..118
NoneNo IPR availableTMHMMTMhelixcoord: 241..263
NoneNo IPR availableTMHMMTMhelixcoord: 179..201
NoneNo IPR availableTMHMMTMhelixcoord: 208..226