Voltage-dependent L-type calcium channel subunit alpha
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30030253 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 15
Homology
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Human
Match: CACNA1C (calcium voltage-gated channel subunit alpha1 C [Source:HGNC Symbol;Acc:HGNC:1390]) HSP 1 Score: 1519.21 bits (3932), Expect = 0.000e+0 Identity = 869/1591 (54.62%), Postives = 1111/1591 (69.83%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN-----NVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQD-GMVKDEKLANGGVGDACSIT---NHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
K + ++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN +V E +DP PC + G G C + +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+NDA G WPWIYFV+LI++GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+V+ G K+EK+ + SIT P + D+ + ENE + E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL YFD +FTT+FTIEI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 90 KKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAE--DDPSPCALETGH-GRQCQNGT--------VCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI------ELKSITADGESPPATKINMDDL--QPNENEDKSPYPNPETTGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635 HSP 2 Score: 85.8853 bits (211), Expect = 8.490e-16 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAIS--------------FNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1172 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Human
Match: CACNA1C (calcium voltage-gated channel subunit alpha1 C [Source:HGNC Symbol;Acc:HGNC:1390]) HSP 1 Score: 1519.21 bits (3932), Expect = 0.000e+0 Identity = 869/1591 (54.62%), Postives = 1111/1591 (69.83%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN-----NVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQD-GMVKDEKLANGGVGDACSIT---NHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
K + ++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN +V E +DP PC + G G C + +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+NDA G WPWIYFV+LI++GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+V+ G K+EK+ + SIT P + D+ + ENE + E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL YFD +FTT+FTIEI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 90 KKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAE--DDPSPCALETGH-GRQCQNGT--------VCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI------ELKSITADGESPPATKINMDDL--QPNENEDKSPYPNPETTGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635 HSP 2 Score: 85.8853 bits (211), Expect = 8.490e-16 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAIS--------------FNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1172 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Human
Match: CACNA1C (calcium voltage-gated channel subunit alpha1 C [Source:HGNC Symbol;Acc:HGNC:1390]) HSP 1 Score: 1518.06 bits (3929), Expect = 0.000e+0 Identity = 873/1605 (54.39%), Postives = 1115/1605 (69.47%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN-----NVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQD-GMVKDEKLANGGVGDACSIT---NHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIP-----------AEDDKKP---MDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
K + ++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN +V E +DP PC + G G C +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+NDA G WPWIYFV+LI++GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+V+ G K+EK+ + SIT P + D+ + ENE + E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL YFD +FTT+FTIEI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK AED +P ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 90 KKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAE--DDPSPCALETGH-GRQCQ--------NGTVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI------ELKSITADGESPPATKINMDDL--QPNENEDKSPYPNPETTGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1654 HSP 2 Score: 85.8853 bits (211), Expect = 1.032e-15 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAIS--------------FNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1172 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Human
Match: CACNA1C (calcium voltage-gated channel subunit alpha1 C [Source:HGNC Symbol;Acc:HGNC:1390]) HSP 1 Score: 1518.06 bits (3929), Expect = 0.000e+0 Identity = 873/1605 (54.39%), Postives = 1115/1605 (69.47%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN-----NVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQD-GMVKDEKLANGGVGDACSIT---NHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIP-----------AEDDKKP---MDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
K + ++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN +V E +DP PC + G G C +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+NDA G WPWIYFV+LI++GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+V+ G K+EK+ + SIT P + D+ + ENE + E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL YFD +FTT+FTIEI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK AED +P ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 90 KKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAE--DDPSPCALETGH-GRQCQ--------NGTVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI------ELKSITADGESPPATKINMDDL--QPNENEDKSPYPNPETTGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDPFRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1654 HSP 2 Score: 85.8853 bits (211), Expect = 1.032e-15 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAIS--------------FNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1172 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Human
Match: CACNA1C (calcium voltage-gated channel subunit alpha1 C [Source:HGNC Symbol;Acc:HGNC:1390]) HSP 1 Score: 1516.52 bits (3925), Expect = 0.000e+0 Identity = 867/1591 (54.49%), Postives = 1109/1591 (69.70%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN-----NVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQD-GMVKDEKLANGGVGDACSIT---NHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
K + ++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN +V E +DP PC + G G C +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+V+ G K+EK+ + SIT P + D+ + ENE + E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL YFD +FTT+FTIEI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 90 KKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIADVPAE--DDPSPCALETGH-GRQCQ--------NGTVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQELVEKPAVGESKEEKI------ELKSITADGESPPATKINMDDL--QPNENEDKSPYPNPETTGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635 HSP 2 Score: 85.8853 bits (211), Expect = 8.447e-16 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAIS--------------FNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1172 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Celegans
Match: unc-2 (High voltage activated calcium channel alpha-1 subunit [Source:UniProtKB/TrEMBL;Acc:Q86G45]) HSP 1 Score: 1111.67 bits (2874), Expect = 0.000e+0 Identity = 681/1575 (43.24%), Postives = 938/1575 (59.56%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNT------KVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN--NVTNEMMEDPKPCMVGLGDDG-YSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPE----------------------------AAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK-KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVD---NQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQ--GHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCT-GTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKI-PAEDDKKPMDQWNEELRSVIKKVWK-RTSPQLLDQIIPPKDS---DTVTVGKFYATFLIQNWFR 4860
K SLF + N +R I++ PFE ILLTI NCVVL M + P D + + LE+ E F+ IF +E LK+I++GF LH+ +YLR+ WNI+DF +V+ GVVT + + + T VD+++LRA RVLRPL+LVSG+PSLQ+VL SI+ AM PL I LLV F ++I++IIG+E + G H+ CYN + E P PC G Y+C K ++W+GPN GIT+FDN G AM+TVFQ +TMEGWT VMY+ ND+ G + W YF+ LI+LGSFF+LNL+LGVLSGEF+KE+E+++ + +F K R ++ ++ GY EWI A+E+ +E+ ++ I + N + E + CH + K ++ R + I +K++ F+ +++LVFLNT + +EH+ QP W F A VF+ +F EM++K+ A+G YF+ FN+FD +++ S E+ + G+SV+R RLLR+FKLT YW SLR+LV L+ SM+SI SLL L+ LFI+IFALLGMQ+FGG++N ++FD F ++ITVFQILTGEDWNE MY I S GG+ G S+YF+VL + GNY LLNVFLAIAVDNL+ N E AE D N+ +E GD C+I T G DM + +D + ++ + + PYS+ F S TN FRV H++VC YF +V+ I +SSV LAAEDP+ + RNK+L Y DY FT VF E+ LK+I G LLHPG++CR+ +N+LD +VV AL +F + + ++ +K LRVLRVLRPL+ I R LK V CVV ++K++ I++V FL F+FAV+AVQLF G+F+ C+D ++ TC GQF Y + + P VE R W P NYDN ++ MLTLFVV T EGWPG+ S+D ED GP + VA+FYV + I+ FF +NIFV +I+TFQ++GE+E +L KNQ++CI+FAL ARPR + P+ +Y++W +V S FEY I+++I NTL L ++ P FY + L + N T VFT+E ILK+ AF +NYF D WN FDF+ V+GS D + ++ G F+S+ F RLFR RL++LL + +IR LLWTF++SF+ALPYV LLI MLFFIYA++GMQ+FG I LN + I+R+NNFQ+F AV++LFR ATGE WQ+IM++ G D C + + CGS V+Y YF SF + SFL++NLFVAVIMDNFDYLTRD SILGPHHLDEFI WADYD A GRI + ++ ML ++PP+GFG CP+ A L+RMNMP+ DGTV F TLFAL+R +L IK+ P E+ MD+ +EELR +KK+W + ++D ++PP +TVGK YA LI +R
Sbjct: 113 KGPSSLFIFAEDNIIRRNAKAIIEWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNERGEIENVSERPMPCTNKTSPMGVYNCD------------VKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEEDEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRI----QIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEV-IWAEVYGGSFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTMHPYTHFDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLA----------------NAQELTAAEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAG----DMC----------------------------AVARAMDDLDEECEEEESPFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEG-SAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITD--------ALVTEFGG-HFVSLGFLRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAA-TEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVQGKD----CARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEE----MDEADEELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYR 1603
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Celegans
Match: unc-2 (High voltage activated calcium channel alpha-1 subunit [Source:UniProtKB/TrEMBL;Acc:Q86G45]) HSP 1 Score: 1111.29 bits (2873), Expect = 0.000e+0 Identity = 681/1575 (43.24%), Postives = 938/1575 (59.56%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNT------KVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN--NVTNEMMEDPKPCMVGLGDDG-YSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPE----------------------------AAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK-KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVD---NQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQ--GHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCT-GTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKI-PAEDDKKPMDQWNEELRSVIKKVWK-RTSPQLLDQIIPPKDS---DTVTVGKFYATFLIQNWFR 4860
K SLF + N +R I++ PFE ILLTI NCVVL M + P D + + LE+ E F+ IF +E LK+I++GF LH+ +YLR+ WNI+DF +V+ GVVT + + + T VD+++LRA RVLRPL+LVSG+PSLQ+VL SI+ AM PL I LLV F ++I++IIG+E + G H+ CYN + E P PC G Y+C K ++W+GPN GIT+FDN G AM+TVFQ +TMEGWT VMY+ ND+ G + W YF+ LI+LGSFF+LNL+LGVLSGEF+KE+E+++ + +F K R ++ ++ GY EWI A+E+ +E+ ++ I + N + E + CH + K ++ R + I +K++ F+ +++LVFLNT + +EH+ QP W F A VF+ +F EM++K+ A+G YF+ FN+FD +++ S E+ + G+SV+R RLLR+FKLT YW SLR+LV L+ SM+SI SLL L+ LFI+IFALLGMQ+FGG++N ++FD F ++ITVFQILTGEDWNE MY I S GG+ G S+YF+VL + GNY LLNVFLAIAVDNL+ N E AE D N+ +E GD C+I T G DM + +D + ++ + + PYS+ F S TN FRV H++VC YF +V+ I +SSV LAAEDP+ + RNK+L Y DY FT VF E+ LK+I G LLHPG++CR+ +N+LD +VV AL +F + + ++ +K LRVLRVLRPL+ I R LK V CVV ++K++ I++V FL F+FAV+AVQLF G+F+ C+D ++ TC GQF Y + + P VE R W P NYDN ++ MLTLFVV T EGWPG+ S+D ED GP + VA+FYV + I+ FF +NIFV +I+TFQ++GE+E +L KNQ++CI+FAL ARPR + P+ +Y++W +V S FEY I+++I NTL L ++ P FY + L + N T VFT+E ILK+ AF +NYF D WN FDF+ V+GS D + ++ G F+S+ F RLFR RL++LL + +IR LLWTF++SF+ALPYV LLI MLFFIYA++GMQ+FG I LN + I+R+NNFQ+F AV++LFR ATGE WQ+IM++ G D C + + CGS V+Y YF SF + SFL++NLFVAVIMDNFDYLTRD SILGPHHLDEFI WADYD A GRI + ++ ML ++PP+GFG CP+ A L+RMNMP+ DGTV F TLFAL+R +L IK+ P E+ MD+ +EELR +KK+W + ++D ++PP +TVGK YA LI +R
Sbjct: 48 KGPSSLFIFAEDNIIRRNAKAIIEWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNERGEIENVSERPMPCTNKTSPMGVYNCD------------VKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEEDEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRI----QIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEV-IWAEVYGGSFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTMHPYTHFDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLA----------------NAQELTAAEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAG----DMC----------------------------AVARAMDDLDEECEEEESPFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEG-SAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITD--------ALVTEFGG-HFVSLGFLRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAA-TEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVQGKD----CARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEE----MDEADEELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYR 1538
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Celegans
Match: unc-2 (High voltage activated calcium channel alpha-1 subunit [Source:UniProtKB/TrEMBL;Acc:Q86G45]) HSP 1 Score: 1111.29 bits (2873), Expect = 0.000e+0 Identity = 681/1575 (43.24%), Postives = 938/1575 (59.56%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNT------KVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN--NVTNEMMEDPKPCMVGLGDDG-YSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPE----------------------------AAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK-KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVD---NQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQ--GHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCT-GTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKI-PAEDDKKPMDQWNEELRSVIKKVWK-RTSPQLLDQIIPPKDS---DTVTVGKFYATFLIQNWFR 4860
K SLF + N +R I++ PFE ILLTI NCVVL M + P D + + LE+ E F+ IF +E LK+I++GF LH+ +YLR+ WNI+DF +V+ GVVT + + + T VD+++LRA RVLRPL+LVSG+PSLQ+VL SI+ AM PL I LLV F ++I++IIG+E + G H+ CYN + E P PC G Y+C K ++W+GPN GIT+FDN G AM+TVFQ +TMEGWT VMY+ ND+ G + W YF+ LI+LGSFF+LNL+LGVLSGEF+KE+E+++ + +F K R ++ ++ GY EWI A+E+ +E+ ++ I + N + E + CH + K ++ R + I +K++ F+ +++LVFLNT + +EH+ QP W F A VF+ +F EM++K+ A+G YF+ FN+FD +++ S E+ + G+SV+R RLLR+FKLT YW SLR+LV L+ SM+SI SLL L+ LFI+IFALLGMQ+FGG++N ++FD F ++ITVFQILTGEDWNE MY I S GG+ G S+YF+VL + GNY LLNVFLAIAVDNL+ N E AE D N+ +E GD C+I T G DM + +D + ++ + + PYS+ F S TN FRV H++VC YF +V+ I +SSV LAAEDP+ + RNK+L Y DY FT VF E+ LK+I G LLHPG++CR+ +N+LD +VV AL +F + + ++ +K LRVLRVLRPL+ I R LK V CVV ++K++ I++V FL F+FAV+AVQLF G+F+ C+D ++ TC GQF Y + + P VE R W P NYDN ++ MLTLFVV T EGWPG+ S+D ED GP + VA+FYV + I+ FF +NIFV +I+TFQ++GE+E +L KNQ++CI+FAL ARPR + P+ +Y++W +V S FEY I+++I NTL L ++ P FY + L + N T VFT+E ILK+ AF +NYF D WN FDF+ V+GS D + ++ G F+S+ F RLFR RL++LL + +IR LLWTF++SF+ALPYV LLI MLFFIYA++GMQ+FG I LN + I+R+NNFQ+F AV++LFR ATGE WQ+IM++ G D C + + CGS V+Y YF SF + SFL++NLFVAVIMDNFDYLTRD SILGPHHLDEFI WADYD A GRI + ++ ML ++PP+GFG CP+ A L+RMNMP+ DGTV F TLFAL+R +L IK+ P E+ MD+ +EELR +KK+W + ++D ++PP +TVGK YA LI +R
Sbjct: 48 KGPSSLFIFAEDNIIRRNAKAIIEWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNERGEIENVSERPMPCTNKTSPMGVYNCD------------VKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEEDEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRI----QIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEV-IWAEVYGGSFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTMHPYTHFDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLA----------------NAQELTAAEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAG----DMC----------------------------AVARAMDDLDEECEEEESPFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEG-SAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITD--------ALVTEFGG-HFVSLGFLRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAA-TEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVQGKD----CARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEE----MDEADEELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYR 1538
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Celegans
Match: unc-2 (High voltage activated calcium channel alpha-1 subunit [Source:UniProtKB/TrEMBL;Acc:Q86G45]) HSP 1 Score: 1110.9 bits (2872), Expect = 0.000e+0 Identity = 681/1575 (43.24%), Postives = 938/1575 (59.56%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNT------KVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN--NVTNEMMEDPKPCMVGLGDDG-YSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPE----------------------------AAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK-KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVD---NQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQ--GHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCT-GTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKI-PAEDDKKPMDQWNEELRSVIKKVWK-RTSPQLLDQIIPPKDS---DTVTVGKFYATFLIQNWFR 4860
K SLF + N +R I++ PFE ILLTI NCVVL M + P D + + LE+ E F+ IF +E LK+I++GF LH+ +YLR+ WNI+DF +V+ GVVT + + + T VD+++LRA RVLRPL+LVSG+PSLQ+VL SI+ AM PL I LLV F ++I++IIG+E + G H+ CYN + E P PC G Y+C K ++W+GPN GIT+FDN G AM+TVFQ +TMEGWT VMY+ ND+ G + W YF+ LI+LGSFF+LNL+LGVLSGEF+KE+E+++ + +F K R ++ ++ GY EWI A+E+ +E+ ++ I + N + E + CH + K ++ R + I +K++ F+ +++LVFLNT + +EH+ QP W F A VF+ +F EM++K+ A+G YF+ FN+FD +++ S E+ + G+SV+R RLLR+FKLT YW SLR+LV L+ SM+SI SLL L+ LFI+IFALLGMQ+FGG++N ++FD F ++ITVFQILTGEDWNE MY I S GG+ G S+YF+VL + GNY LLNVFLAIAVDNL+ N E AE D N+ +E GD C+I T G DM + +D + ++ + + PYS+ F S TN FRV H++VC YF +V+ I +SSV LAAEDP+ + RNK+L Y DY FT VF E+ LK+I G LLHPG++CR+ +N+LD +VV AL +F + + ++ +K LRVLRVLRPL+ I R LK V CVV ++K++ I++V FL F+FAV+AVQLF G+F+ C+D ++ TC GQF Y + + P VE R W P NYDN ++ MLTLFVV T EGWPG+ S+D ED GP + VA+FYV + I+ FF +NIFV +I+TFQ++GE+E +L KNQ++CI+FAL ARPR + P+ +Y++W +V S FEY I+++I NTL L ++ P FY + L + N T VFT+E ILK+ AF +NYF D WN FDF+ V+GS D + ++ G F+S+ F RLFR RL++LL + +IR LLWTF++SF+ALPYV LLI MLFFIYA++GMQ+FG I LN + I+R+NNFQ+F AV++LFR ATGE WQ+IM++ G D C + + CGS V+Y YF SF + SFL++NLFVAVIMDNFDYLTRD SILGPHHLDEFI WADYD A GRI + ++ ML ++PP+GFG CP+ A L+RMNMP+ DGTV F TLFAL+R +L IK+ P E+ MD+ +EELR +KK+W + ++D ++PP +TVGK YA LI +R
Sbjct: 48 KGPSSLFIFAEDNIIRRNAKAIIEWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNERGEIENVSERPMPCTNKTSPMGVYNCD------------VKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEEDEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRI----QIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEV-IWAEVYGGSFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTMHPYTHFDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLA----------------NAQELTAAEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAG----DMC----------------------------AVARAMDDLDEECEEEESPFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEG-SAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITD--------ALVTEFGG-HFVSLGFLRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAA-TEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVQGKD----CARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEE----MDEADEELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYR 1538
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Celegans
Match: unc-2 (High voltage activated calcium channel alpha-1 subunit [Source:UniProtKB/TrEMBL;Acc:Q86G45]) HSP 1 Score: 1110.9 bits (2872), Expect = 0.000e+0 Identity = 681/1575 (43.24%), Postives = 938/1575 (59.56%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNT------KVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN--NVTNEMMEDPKPCMVGLGDDG-YSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPE----------------------------AAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK-KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVD---NQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQ--GHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCT-GTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKI-PAEDDKKPMDQWNEELRSVIKKVWK-RTSPQLLDQIIPPKDS---DTVTVGKFYATFLIQNWFR 4860
K SLF + N +R I++ PFE ILLTI NCVVL M + P D + + LE+ E F+ IF +E LK+I++GF LH+ +YLR+ WNI+DF +V+ GVVT + + + T VD+++LRA RVLRPL+LVSG+PSLQ+VL SI+ AM PL I LLV F ++I++IIG+E + G H+ CYN + E P PC G Y+C K ++W+GPN GIT+FDN G AM+TVFQ +TMEGWT VMY+ ND+ G + W YF+ LI+LGSFF+LNL+LGVLSGEF+KE+E+++ + +F K R ++ ++ GY EWI A+E+ +E+ ++ I + N + E + CH + K ++ R + I +K++ F+ +++LVFLNT + +EH+ QP W F A VF+ +F EM++K+ A+G YF+ FN+FD +++ S E+ + G+SV+R RLLR+FKLT YW SLR+LV L+ SM+SI SLL L+ LFI+IFALLGMQ+FGG++N ++FD F ++ITVFQILTGEDWNE MY I S GG+ G S+YF+VL + GNY LLNVFLAIAVDNL+ N E AE D N+ +E GD C+I T G DM + +D + ++ + + PYS+ F S TN FRV H++VC YF +V+ I +SSV LAAEDP+ + RNK+L Y DY FT VF E+ LK+I G LLHPG++CR+ +N+LD +VV AL +F + + ++ +K LRVLRVLRPL+ I R LK V CVV ++K++ I++V FL F+FAV+AVQLF G+F+ C+D ++ TC GQF Y + + P VE R W P NYDN ++ MLTLFVV T EGWPG+ S+D ED GP + VA+FYV + I+ FF +NIFV +I+TFQ++GE+E +L KNQ++CI+FAL ARPR + P+ +Y++W +V S FEY I+++I NTL L ++ P FY + L + N T VFT+E ILK+ AF +NYF D WN FDF+ V+GS D + ++ G F+S+ F RLFR RL++LL + +IR LLWTF++SF+ALPYV LLI MLFFIYA++GMQ+FG I LN + I+R+NNFQ+F AV++LFR ATGE WQ+IM++ G D C + + CGS V+Y YF SF + SFL++NLFVAVIMDNFDYLTRD SILGPHHLDEFI WADYD A GRI + ++ ML ++PP+GFG CP+ A L+RMNMP+ DGTV F TLFAL+R +L IK+ P E+ MD+ +EELR +KK+W + ++D ++PP +TVGK YA LI +R
Sbjct: 113 KGPSSLFIFAEDNIIRRNAKAIIEWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNERGEIENVSERPMPCTNKTSPMGVYNCD------------VKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRRAANKKLKQASKQQSTETEEDFEEDEDEMEEEYVDEAERKKRGCCHSVGKFIKQLRI----QIRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSRTYFASKFNRFDCVVIVGSAAEV-IWAEVYGGSFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTMHPYTHFDTFPVALITVFQILTGEDWNEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLA----------------NAQELTAAEEADEKANEIEEESEELDEQYQEGDHCTIDMEGKTAG----DMC----------------------------AVARAMDDLDEECEEEESPFGGPKPMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVICLSSVSLAAEDPVDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAFGFAGTEG-SAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTALTAVFTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITD--------ALVTEFGG-HFVSLGFLRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVGMQVFGNIWLNAA-TEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVQGKD----CARAGSAEINFEKGQTCGSNVSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSIKMRPVEE----MDEADEELRLTLKKIWPLKAKKNMVDLVVPPNHELCFQKLTVGKIYAGLLILENYR 1603
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Fly
Match: Ca-alpha1D (gene:FBgn0001991 transcript:FBtr0332020) HSP 1 Score: 1585.47 bits (4104), Expect = 0.000e+0 Identity = 902/1678 (53.75%), Postives = 1152/1678 (68.65%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLG-DDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEE-----NDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS---RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKS---HKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGK---------------TKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPK-DSDTVTVGKFYATFLIQNWFRDWQRRK--------------MIQKDIRYIPQIT-AGDRSMQG---------QPLILGLPRRTSSELIGDEFKA-RKKGTQNDEKETKKDFSLSTKRLITPPSNQAI-----SNPVLQSSLPNGG 5142
+P R+LFCL KNP+R RIV+ KPFE LILLTIFANC+ L + PYP DSN TN+ LEK+E VF+VIFT E +KI++YGF+LH AYLRN WN+LDF IV+IG ++ L+ + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSI+ AM PLFHIALLV F+++IY+IIG+ELF GKLH C + +T E E+ +PC VG GY C G W GPNDGITNFDNFGLAMLTVFQ +T+EGWT V+Y I DA G W W+YF+S+++LG+FFV+NLILGVLSGEFSKE+ K + FQK RE ++ +D GY +WI +A+++ + +DG E+ ++ N E +M +SR K+ K F + R RR+ +KS+ F+ LI+ LVFLNT VL TEH+ Q WLD+FQ+ N+ F+ LFT EM++K+ +LG YF FN+FD F+V+ SI E LT ++ P+G+SVLRC RLLRVFK+T+YW SL +LV LL S++SI SLLLL+ LFIVIFALLGMQ+FGGK+N D K R NFD FWQ+++TVFQI+TGEDWN MY GI ++GGV+ GAL +YF++LFI GNYILLNVFLAIAVDNL+D D E + + + +++++ DGM D+ L+ DM ++ ++E + + +V E E E +V +A PRR +MK + IP SAFFIFS TN+FRVFCH + HS FGNI+L CI+ SS MLAAE+P+R + NK+LN FDY FT VFTIE+ LK+I+YGF+LH GAFCR+ FNLLDLLV + ++ + AIS VKILRVLRVLRPLRAINRAKGLK+VV+CVVVA+K+IG IMLVT+LL FMFAV+ VQLFKG+F+ C+D SK+T + C G ++ Y HK P + R W NN ++D+V GMLTLF V+TFEGWPGLLY SID+ KE+ GP++N+ VA +Y+ YIIIIAFFM+NIFVGFVIVTFQ EGE EYKNC+L KNQR CIEFALKA+P +RY P+ ++YK+W V S FEY I LI+ NT+ LA +F QP +YT+ LD LN+IFT VF LEF+ KL+AF FKNYF DAWN+FDFI+VLGS++DI+ S +SQ+ + + ISINFFRLFRVMRLVKLLSK + IR LLWTFIKSFQALPYVALLIV+LFFIYAV+GMQ+FGKIAL+ + +I+ NNNFQTF AVLVLFRSATGE+WQEIM+SC+ + +C++ + + CGS +AYPYFISFY++CSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFI W++YD +AKGRI+HLDVVT+L KISPPLGFG +CPH AC +LV MNMPL +DGTVLFNATLFA+VR +L IK +D N ELR+ IK++WKRT+P+LLDQ++PP + D VTVGKFYAT+LIQ++FR +++RK +Q +R + +++ A R++ G +P+ R L G + + R+ G + K S S L S A S+ VL SS P GG
Sbjct: 622 RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQL-MKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYG-------------------GWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDST--ENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGM--DDHLS-------------------IDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVSARV-TARPRRLSEVSMKKTKKPIPRGSAFFIFSYTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLV-------VCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHK--PRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGN-AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPD-VKCDMNSDTPG-----EPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGN-----IDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPM-----HRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGG 2229
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Fly
Match: Ca-alpha1D (gene:FBgn0001991 transcript:FBtr0090005) HSP 1 Score: 1580.84 bits (4092), Expect = 0.000e+0 Identity = 904/1682 (53.75%), Postives = 1150/1682 (68.37%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLG-DDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEE-----NDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS---RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSAC----PRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKS---HKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGK---------------TKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPK-DSDTVTVGKFYATFLIQNWFRDWQRRK--------------MIQKDIRYIPQIT-AGDRSMQG---------QPLILGLPRRTSSELIGDEFKA-RKKGTQNDEKETKKDFSLSTKRLITPPSNQAI-----SNPVLQSSLPNGG 5142
+P R+LFCL KNP+R RIV+ KPFE LILLTIFANC+ L + PYP DSN TN+ LEK+E VF+VIFT E +KI++YGF+LH AYLRN WN+LDF IV+IG ++ L+ + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSI+ AM PLFHIALLV F+++IY+IIG+ELF GKLH C + +T E E+ +PC VG GY C G W GPNDGITNFDNFGLAMLTVFQ +T+EGWT V+Y I DA G W W+YF+S+++LG+FFV+NLILGVLSGEFSKE+ K + FQK RE ++ +D GY +WI +A+++ + +DG E+ ++ N E +M +SR K+ K F + R RR+ +KS+ F+ LI+ LVFLNT VL TEH+ Q WLD+FQ+ N+ F+ LFT EM++K+ +LG YF FN+FD F+V+ SI E LT ++ P+G+SVLRC RLLRVFK+T+YW SL +LV LL S++SI SLLLL+ LFIVIFALLGMQ+FGGK+N D K R NFD FWQ+++TVFQI+TGEDWN MY GI ++GGV+ GAL +YF++LFI GNYILLNVFLAIAVDNL+D D E + + + +++++ DGM D+ L+ DM ++ ++E + + +V E E ED SA PRR +MK + IP SAFFIFS TN+FRVFCH + HS FGNI+L CI+ SS MLAAE+P+R + NK+LN FDY FT VFTIE+ LK+I+YGF+LH GAFCR+ FNLLDLLV + ++ + AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV+VAVK+IG I+LVT LL FMFAV+ VQLFKG+F+ C+D SK+T + C G ++ Y HK P + R W NN ++D+V GMLTLF V+TFEGWPGLLY SID+ KE+ GP++N+ VA +Y+ YIIIIAFFM+NIFVGFVIVTFQ EGE EYKNC+L KNQR CIEFALKA+P +RY P+ ++YK+W V S FEY I LI+ NT+ LA +F QP +YT+ LD LN+IFT VF LEF+ KL+AF FKNYF DAWN+FDFI+VLGS++DI+ S +SQ+ + + ISINFFRLFRVMRLVKLLSK + IR LLWTFIKSFQALPYVALLIV+LFFIYAV+GMQ+FGKIAL+ + +I+ NNNFQTF AVLVLFRSATGE+WQEIM+SC+ + +C++ + + CGS +AYPYFISFY++CSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFI W++YD +AKGRI+HLDVVT+L KISPPLGFG +CPH AC +LV MNMPL +DGTVLFNATLFA+VR +L IK +D N ELR+ IK++WKRT+P+LLDQ++PP + D VTVGKFYAT+LIQ++FR +++RK +Q +R + +++ A R++ G +P+ R L G + + R+ G + K S S L S A S+ VL SS P GG
Sbjct: 590 RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQL-MKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYG-------------------GWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDST--ENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGM--DDHLS-------------------IDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEDSNSEVSARVTARPRRLSEVSMKKTKKPIPRGSAFFIFSYTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLV-------VCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHK--PRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGN-AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPD-VKCDMNSDTPG-----EPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGN-----IDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPM-----HRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGG 2202 HSP 2 Score: 82.4185 bits (202), Expect = 5.586e-15 Identity = 88/376 (23.40%), Postives = 150/376 (39.89%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGM---NRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAI-----------------------SFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWIN---------------DAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
EG + + C K R+ C+E K PVR +I + V S FE I + I N V L M N+P +L+ L ++F +F +E K+ ++ F Y +AWN+ DF IV+ + + + I + + + I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY+++GM++F GK+ LD G + I +N NF F A+L +F++ T E W ++M + + G + YF+S +L SF ++NL + V+ F
Sbjct: 1619 EGEQEYKNCDLDKNQRN--CIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFRF----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVF-GKI----------------------------------ALDGGNA-ITANN--------------NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 1932
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Fly
Match: Ca-alpha1D (gene:FBgn0001991 transcript:FBtr0090006) HSP 1 Score: 1580.46 bits (4091), Expect = 0.000e+0 Identity = 901/1679 (53.66%), Postives = 1150/1679 (68.49%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLG-DDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEE-----NDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS---RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYX-XXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKS---HKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGK---------------TKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPK-DSDTVTVGKFYATFLIQNWFRDWQRRK--------------MIQKDIRYIPQIT-AGDRSMQG---------QPLILGLPRRTSSELIGDEFKA-RKKGTQNDEKETKKDFSLSTKRLITPPSNQAI-----SNPVLQSSLPNGG 5142
+P R+LFCL KNP+R RIV+ KPFE LILLTIFANC+ L + PYP DSN TN+ LEK+E VF+VIFT E +KI++YGF+LH AYLRN WN+LDF IV+IG ++ L+ + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSI+ AM PLFHIALLV F+++IY+IIG+ELF GKLH C + +T E E+ +PC VG GY C G W GPNDGITNFDNFGLAMLTVFQ +T+EGWT V+Y I DA G W W+YF+S+++LG+FFV+NLILGVLSGEFSKE+ K + FQK RE ++ +D GY +WI +A+++ + +DG E+ ++ N E +M +SR K+ K F + R RR+ +KS+ F+ LI+ LVFLNT VL TEH+ Q WLD+FQ+ N+ F+ LFT EM++K+ +LG YF FN+FD F+V+ SI E LT ++ P+G+SVLRC RLLRVFK+T+YW SL +LV LL S++SI SLLLL+ LFIVIFALLGMQ+FGGK+N D K R NFD FWQ+++TVFQI+TGEDWN MY GI ++GGV+ GAL +YF++LFI GNYILLNVFLAIAVDNL+D D E + + + +++++ DGM D+ L+ DM ++ ++E + E E EE D + + +A PRR N T+ IPP ++FF+FS TN+FRVFCH + HS FGNI+L CI+ SS MLAAE+P+R + NK+LN FDY FT VFTIE+ LK+I+YGF+LH GAFCR+ FNLLDLLV + ++ + AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV+VAVK+IG I+LVT LL FMFAV+ VQLFKG+F+ C+D SK+T + C G ++ Y HK P + R W NN ++D+V GMLTLF V+TFEGWPGLLY SID+ KE+ GP++N+ VA +Y+ YIIIIAFFM+NIFVGFVIVTFQ EGE EYKNC+L KNQR CIEFALKA+P +RY P+ ++YK+W V S FEY I LI+ NT+ LA +F QP +YT+ LD LN+IFT VF LEF+ KL+AF FKNYF DAWN+FDFI+VLGS++DI+ S +SQ+ + + ISINFFRLFRVMRLVKLLSK + IR LLWTFIKSFQALPYVALLIV+LFFIYAV+GMQ+FGKIAL+ + +I+ NNNFQTF AVLVLFRSATGE+WQEIM+SC+ + +C++ + + CGS +AYPYFISFY++CSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFI W++YD +AKGRI+HLDVVT+L KISPPLGFG +CPH AC +LV MNMPL +DGTVLFNATLFA+VR +L IK +D N ELR+ IK++WKRT+P+LLDQ++PP + D VTVGKFYAT+LIQ++FR +++RK +Q +R + +++ A R++ G +P+ R L G + + R+ G + K S S L S A S+ VL SS P GG
Sbjct: 590 RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQL-MKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYG-------------------GWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDST--ENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGM--DDHLS-------------------IDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLV-------VCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHK--PRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGN-AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPD-VKCDMNSDTPG-----EPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGN-----IDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPM-----HRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGG 2199 HSP 2 Score: 120.168 bits (300), Expect = 1.946e-26 Identity = 98/329 (29.79%), Postives = 158/329 (48.02%), Query Frame = 1
Query: 280 LKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPL-DEGQSWICKDNNLTER-WVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLIL---------LGSFFVLNLILGVLSGEFSKEKEK 1233
+ P S F + N R+F + + F +IL I + +L P A D N++L K + F +FTIE LK+ISYGF+LH A+ R+A+N+LD +V V+ I S N +K LR RVLRPLR ++ L+ V+ +I A+K + +I L+ L ++++IG++LF GK C + ++M +D C G + D+G L ER W ++ +FD+ MLT+F T EGW ++Y D+ I+ I+ + +FF++N+ +G + F E E+
Sbjct: 1318 IPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDD--LNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVV---CVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFF-KCTDG--SKMTQD-------------ECYGTYLVYDDGD---VHKPRLREREW---SNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQ 1619 HSP 3 Score: 82.0333 bits (201), Expect = 6.891e-15 Identity = 88/376 (23.40%), Postives = 150/376 (39.89%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGM---NRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAI-----------------------SFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWIN---------------DAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
EG + + C K R+ C+E K PVR +I + V S FE I + I N V L M N+P +L+ L ++F +F +E K+ ++ F Y +AWN+ DF IV+ + + + I + + + I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY+++GM++F GK+ LD G + I +N NF F A+L +F++ T E W ++M + + G + YF+S +L SF ++NL + V+ F
Sbjct: 1616 EGEQEYKNCDLDKNQRN--CIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFRF----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVF-GKI----------------------------------ALDGGNA-ITANN--------------NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 1929
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Fly
Match: Ca-alpha1D (gene:FBgn0001991 transcript:FBtr0332023) HSP 1 Score: 1580.46 bits (4091), Expect = 0.000e+0 Identity = 902/1677 (53.79%), Postives = 1152/1677 (68.69%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLG-DDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDG-NSDDYREISTSLDHNQNPEAAIEE--MAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS---RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYX-XXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKS---HKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGK---------------TKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPK-DSDTVTVGKFYATFLIQNWFRDWQRRK--------------MIQKDIRYIPQIT-AGDRSMQG---------QPLILGLPRRTSSELIGDEFKA-RKKGTQNDEKETKKDFSLSTKRLITPPSNQAI-----SNPVLQSSLPNGG 5142
+P R+LFCL KNP+R RIV+ KPFE LILLTIFANC+ L + PYP DSN TN+ LEK+E VF+VIFT E +KI++YGF+LH AYLRN WN+LDF IV+IG ++ L+ + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSI+ AM PLFHIALLV F+++IY+IIG+ELF GKLH C + +T E E+ +PC VG GY C G W GPNDGITNFDNFGLAMLTVFQ +T+EGWT V+Y I DA G W W+YF+S+++LG+FFV+NLILGVLSGEFSKE+ K + FQK RE ++ +D GY +WI +A+++ + G SD + +D +N + E M +SR K+ K F + R RR+ +KS+ F+ LI+ LVFLNT VL TEH+ Q WLD+FQ+ N+ F+ LFT EM++K+ +LG YF FN+FD F+V+ SI E LT ++ P+G+SVLRC RLLRVFK+T+YW SL +LV LL S++SI SLLLL+ LFIVIFALLGMQ+FGGK+N D K R NFD FWQ+++TVFQI+TGEDWN MY GI ++GGV+ GAL +YF++LFI GNYILLNVFLAIAVDNL+D D E + + + +++++ DGM D+ L+ DM ++ ++E + E E EE D + + +A PRR N T+ IPP ++FF+FS TN+FRVFCH + HS FGNI+L CI+ SS MLAAE+P+R + NK+LN FDY FT VFTIE+ LK+I+YGF+LH GAFCR+ FNLLDLLVV + ++ + AIS VKILRVLRVLRPLRAINRAKGLK+VV+CVVVA+K+IG IMLVT+LL FMFAV+ VQLFKG+F+ C+D SK+T + C G ++ Y HK P + R W NN ++D+V GMLTLF V+TFEGWPGLLY SID+ KE+ GP++N+ VA +Y+ YIIIIAFFM+NIFVGFVIVTFQ EGE EYKNC+L KNQR CIEFALKA+P +RY P+ ++YK+W V S FEY I LI+ NT+ LA +F QP +YT+ LD LN+IFT VF LEF+ KL+AF FKNYF DAWN+FDFI+VLGS++DI+ S +SQ+ + + ISINFFRLFRVMRLVKLLSK + IR LLWTFIKSFQALPYVALLIV+LFFIYAV+GMQ+FGKIAL+ + +I+ NNNFQTF AVLVLFRSATGE+WQEIM+SC+ + +C++ + + CGS +AYPYFISFY++CSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFI W++YD +AKGRI+HLDVVT+L KISPPLGFG +CPH AC +LV MNMPL +DGTVLFNATLFA+VR +L IK +D N ELR+ IK++WKRT+P+LLDQ++PP + D VTVGKFYAT+LIQ++FR +++RK +Q +R + +++ A R++ G +P+ R L G + + R+ G + K S S L S A S+ VL SS P GG
Sbjct: 97 RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQL-MKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYG-------------------GWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGM--DDHLS-------------------IDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVV-------CVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHK--PRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGN-AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPD-VKCDM-----NSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGN-----IDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPM-----HRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGG 1706 HSP 2 Score: 204.912 bits (520), Expect = 2.596e-52 Identity = 186/691 (26.92%), Postives = 308/691 (44.57%), Query Frame = 1
Query: 280 LKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPL-DEGQSWICKDNNLTER-WVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLIL---------LGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIEL-----------------------SLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK----KSRSNFDHFWQSVITVFQILTGEDWNEEMYN---------GIRSFGGVNGLGALVSL-YFVVLFIVGNYILLNVFLAIAVDNL 2208
+ P S F + N R+F + + F +IL I + +L P A D N++L K + F +FTIE LK+ISYGF+LH A+ R+A+N+LD +V V+ I S N +K LR RVLRPLR ++ L+ V+ ++ A+K + +I L+ + L ++++IG++LF GK C + ++M +D C G + D+G L ER W ++ +FD+ MLT+F T EGW ++Y D+ I+ I+ + +FF++N+ +G + FQ E E + +N D LD NQ AK I K + + V ++ S F I L+ +NT+ L + + QPLW D N++F A+F E V K+ A YF A+N FD IVL S I++ S + N I ++ R R++R+ KL +R+L+ +KS +++ + LL+ L I+A++GMQ+F GK LD + +NF F Q+V+ +F+ TGE W E M + + S G+ ++ YF+ +++ +++++N+F+A+ +DN
Sbjct: 825 IPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDD--LNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVV---CVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFF-KCTDG--SKMTQD-------------ECYGTYLVYDDGD---VHKPRLREREW---SNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI-------------VTFQNEGEQEYKNCD--------------------------------LDKNQRNCIEFALKAKPVRRYIPK------HGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVF-GKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 1436 HSP 3 Score: 81.6481 bits (200), Expect = 8.884e-15 Identity = 88/376 (23.40%), Postives = 150/376 (39.89%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGM---NRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAI-----------------------SFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWIN---------------DAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
EG + + C K R+ C+E K PVR +I + V S FE I + I N V L M N+P +L+ L ++F +F +E K+ ++ F Y +AWN+ DF IV+ + + + I + + + I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY+++GM++F GK+ LD G + I +N NF F A+L +F++ T E W ++M + + G + YF+S +L SF ++NL + V+ F
Sbjct: 1123 EGEQEYKNCDLDKNQRN--CIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFRF----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVF-GKI----------------------------------ALDGGNA-ITANN--------------NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 1436
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Fly
Match: Ca-alpha1D (gene:FBgn0001991 transcript:FBtr0090003) HSP 1 Score: 1578.15 bits (4085), Expect = 0.000e+0 Identity = 902/1677 (53.79%), Postives = 1150/1677 (68.57%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLG-DDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDG-NSDDYREISTSLDHNQNPEAAIEE--MAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS---RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYX-XXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKS---HKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGK---------------TKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPK-DSDTVTVGKFYATFLIQNWFRDWQRRK--------------MIQKDIRYIPQIT-AGDRSMQG---------QPLILGLPRRTSSELIGDEFKA-RKKGTQNDEKETKKDFSLSTKRLITPPSNQAI-----SNPVLQSSLPNGG 5142
+P R+LFCL KNP+R RIV+ KPFE LILLTIFANC+ L + PYP DSN TN+ LEK+E VF+VIFT E +KI++YGF+LH AYLRN WN+LDF IV+IG ++ L+ + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSI+ AM PLFHIALLV F+++IY+IIG+ELF GKLH C + +T E E+ +PC VG GY C G W GPNDGITNFDNFGLAMLTVFQ +T+EGWT V+Y I DA G W W+YF+S+++LG+FFV+NLILGVLSGEFSKE+ K + FQK RE ++ +D GY +WI +A+++ + G SD + +D +N + E M +SR K+ K F + R RR+ +KS+ F+ LI+ LVFLNT VL TEH+ Q WLD+FQ+ N+ F+ LFT EM++K+ +LG YF FN+FD F+V+ SI E LT ++ P+G+SVLRC RLLRVFK+T+YW SL +LV LL S++SI SLLLL+ LFIVIFALLGMQ+FGGK+N D K R NFD FWQ+++TVFQI+TGEDWN MY GI ++GGV+ GAL +YF++LFI GNYILLNVFLAIAVDNL+D D E + + + +++++ DGM D+ L+ DM ++ ++E + E E EE D + + +A PRR N T+ IPP ++FF+FS TN+FRVFCH + HS FGNI+L CI+ SS MLAAE+P+R + NK+LN FDY FT VFTIE+ LK+I+YGF+LH GAFCR+ FNLLDLLV + ++ + AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV+VAVK+IG I+LVT LL FMFAV+ VQLFKG+F+ C+D SK+T + C G ++ Y HK P + R W NN ++D+V GMLTLF V+TFEGWPGLLY SID+ KE+ GP++N+ VA +Y+ YIIIIAFFM+NIFVGFVIVTFQ EGE EYKNC+L KNQR CIEFALKA+P +RY P+ ++YK+W V S FEY I LI+ NT+ LA +F QP +YT+ LD LN+IFT VF LEF+ KL+AF FKNYF DAWN+FDFI+VLGS++DI+ S +SQ+ + + ISINFFRLFRVMRLVKLLSK + IR LLWTFIKSFQALPYVALLIV+LFFIYAV+GMQ+FGKIAL+ + +I+ NNNFQTF AVLVLFRSATGE+WQEIM+SC+ + +C++ + + CGS +AYPYFISFY++CSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFI W++YD +AKGRI+HLDVVT+L KISPPLGFG +CPH AC +LV MNMPL +DGTVLFNATLFA+VR +L IK +D N ELR+ IK++WKRT+P+LLDQ++PP + D VTVGKFYAT+LIQ++FR +++RK +Q +R + +++ A R++ G +P+ R L G + + R+ G + K S S L S A S+ VL SS P GG
Sbjct: 590 RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQL-MKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYG-------------------GWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGM--DDHLS-------------------IDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLV-------VCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHK--PRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGN-AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPD-VKCDM-----NSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGN-----IDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPM-----HRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGG 2199 HSP 2 Score: 119.783 bits (299), Expect = 2.170e-26 Identity = 98/329 (29.79%), Postives = 158/329 (48.02%), Query Frame = 1
Query: 280 LKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPL-DEGQSWICKDNNLTER-WVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLIL---------LGSFFVLNLILGVLSGEFSKEKEK 1233
+ P S F + N R+F + + F +IL I + +L P A D N++L K + F +FTIE LK+ISYGF+LH A+ R+A+N+LD +V V+ I S N +K LR RVLRPLR ++ L+ V+ +I A+K + +I L+ L ++++IG++LF GK C + ++M +D C G + D+G L ER W ++ +FD+ MLT+F T EGW ++Y D+ I+ I+ + +FF++N+ +G + F E E+
Sbjct: 1318 IPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDD--LNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVV---CVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFF-KCTDG--SKMTQD-------------ECYGTYLVYDDGD---VHKPRLREREW---SNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQ 1619 HSP 3 Score: 82.0333 bits (201), Expect = 7.258e-15 Identity = 88/376 (23.40%), Postives = 150/376 (39.89%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGM---NRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAI-----------------------SFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWIN---------------DAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
EG + + C K R+ C+E K PVR +I + V S FE I + I N V L M N+P +L+ L ++F +F +E K+ ++ F Y +AWN+ DF IV+ + + + I + + + I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY+++GM++F GK+ LD G + I +N NF F A+L +F++ T E W ++M + + G + YF+S +L SF ++NL + V+ F
Sbjct: 1616 EGEQEYKNCDLDKNQRN--CIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFRF----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVF-GKI----------------------------------ALDGGNA-ITANN--------------NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 1929
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Zebrafish
Match: cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:ZFIN;Acc:ZDB-GENE-020129-1]) HSP 1 Score: 1501.88 bits (3887), Expect = 0.000e+0 Identity = 857/1604 (53.43%), Postives = 1106/1604 (68.95%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT-------AISFNTKV---DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCY----NNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTE---RWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPE-----AAIEEMAKSRC----------HKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDE--KLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYK-SHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXX--------------XXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITA 4920
K + +S +P R+L CL KNP+R IV+ KPFE++IL+TIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL S K D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TC+ + + E P PC + C N+T+ W GPNDGITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E +D DD + + S+ ++N A +M C K + R+ RR +KS F+ L++ LVFLNT+ + +EHH+QP WL + QDIAN V +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + + + + + + + K + SIT+ T T ++ + E ++EK Y D E+ E V PR +K ++ +P AFFIFS +NKFRV CH +V H+ F N++L IL+SS+ LAAEDP++ S RN+IL Y DY+FT +FTIEI LKM AYG LH G+FCRN FN+LDL+VV V+L+S I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+F+ C+D+SK T C+G +I YK + P R+WEN+ N+D+VL GM+ LF V+TFEGWPGLLY++ID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ +LIL NT+CLA + Q + + ++ILN++FT +FT+E ILKL AF ++YF DAWN FD ++V+GS VDI I+ N + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL + +S I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C+ CE + + + CGS A YF+SFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR+++KK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK Q + IP TA
Sbjct: 100 KKQASTASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPSSAHGRH---------------CSPPNITQCMMGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSITSDGETPTATKINI--DEYTGEDNEEKNPYPVNDFPAGEDDEEEPEMPVGPR-PRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTSKQTQAECRGAYILYKDGNVGKPEKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRHYFVDAWNTFDALIVVGSVVDIAITEVNPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRD-NSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACS---PNRPCE---KGSEINHSSEDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE-QGLVAKIPPKTA 1665
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Zebrafish
Match: cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:ZFIN;Acc:ZDB-GENE-020129-1]) HSP 1 Score: 1487.63 bits (3850), Expect = 0.000e+0 Identity = 858/1632 (52.57%), Postives = 1105/1632 (67.71%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT-------AISFNTKV---DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCY----NNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTE---RWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPE-----AAIEEMAKSRC----------HKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDAC--SITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYK-SHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSD----------------------------AWNIFDFIVVLGSYVDXXXXXXXXX--------------XXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITA 4920
K + +S +P R+L CL KNP+R IV+ KPFE++IL+TIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL S K D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TC+ + + E P PC + C N+T+ W GPNDGITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E +D DD + + S+ ++N A +M C K + R+ RR +KS F+ L++ LVFLNT+ + +EHH+QP WL + QDIAN V +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + + + + + + + K SIT+ T T ++ + E ++EK Y D E+ E V PR +K ++ +P AFFIFS +NKFRV CH +V H+ F N++L IL+SS+ LAAEDP++ S RN+IL Y DY+FT +FTIEI LKM AYG LH G+FCRN FN+LDL+VV V+L+S I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+F+ C+D+SK T C+G +I YK + P R+WEN+ N+D+VL GM+ LF V+TFEGWPGLLY++ID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ +LIL NT+CLA + Q + + ++ILN++FT +FT+E ILKL AF + YFSD AWN FD ++V+GS VDI I+ N + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL + +S I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C+ CE + + + CGS A YF+SFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR+++KK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK Q + IP TA
Sbjct: 100 KKQASTASTRPPRALLCLTLKNPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTCFFYKDGHKGHIAEEKPAPCAPSSAHGRH---------------CSPPNITQCMMGWEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDDEGLDDDKPRNLSMPASENESVNTDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHHQQPEWLTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKRQNSEKPPLEDEKKEEKIELKSITSDGETPTATKINI--DEYTGEDNEEKNPYPVNDFPAGEDDEEEPEMPVGPR-PRPLSDIQLKEKAVPMPQAKAFFIFSPSNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTDTSKQTQAECRGAYILYKDGNVGKPEKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTGLFTVEMILKLIAFKPRGYFSDPWNVFDFLIVIGSIIDVILSEINHYFVDAWNTFDALIVVGSVVDIAITEVNPADPSSSPPSSVVRPMGLQNTEDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRD-NSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACS---PNRPCE---KGSEINHSSEDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE-QGLVAKIPPKTA 1693
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Zebrafish
Match: cacna1sa (calcium channel, voltage-dependent, L type, alpha 1S subunit, a [Source:ZFIN;Acc:ZDB-GENE-090514-1]) HSP 1 Score: 1441.02 bits (3729), Expect = 0.000e+0 Identity = 847/1655 (51.18%), Postives = 1104/1655 (66.71%), Query Frame = 1
Query: 208 FIADLALAALKDREGAKHRQLCS-SLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKV----------DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDE-GQSWICKDNNLTER--WVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNL--DKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEK--LANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVG-------------------KTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIP--------QITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDE 5034
FI D K RE K Q + +P RSL L KNP R IV+ KPFE++ILLTIFANCV L + P P D+N+TN LE LE +F++IFT+E LKI++YGFL H +AYLRN WNILDF IV +G+ T ++ I+ + V D+K+LRAFRVLRPLRLVSG+PSLQ+V++SI+ +M PLFHI+LLVFF+V IY+IIG+ELF K+H TCY+ T+ ++ GDD + +P + G C N R W GPN+GIT+FDN G +MLTV+Q +T +GWT V+YW+NDA G +WPW+YFV+LILLGSFF+LNL+LGVL GEF+KE+EK R ++Q RE ++ ++D GY EWI +A E+ D + +G L E E ++ ++ R+ +RR +++KSK F+ L++ LVF NT+ + TEHH+QP L +FQD N ++LF EM +K+ A+GL YF FN+FD F+V I+EL L R V++ +G+SVLRC RLLR+ K+T++W +L +LV LL S++SI SLLLL+ LFIVIFALLGMQ+FGGK+N D+ RSNFD+F Q++ITVFQILTGE WN MY+GI + GG G LVS+YF++LFI GNYILLNVFLAIAVDNL++ + + A+ + + ++ + +N ++EK LA I P+T L + FE+ ++ K + D ++E + S PR +K +P SAFF+F NKFR CH ++ + F NI+L+ IL+SS+ LAAEDPI S RN++L Y DY+FT+VFT EI LKM YG LH G+FCRN+FN+LDL+VV V+L+S ++ + AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+K+IG I+LVT LL FMFA + VQLFKG+F C+D K+T E C+G FI ++ + + V R W N+ LN+DNVL+GML LF V+TFEGWP LLYK+ID+ E+ GPVYN + ++IF++ Y+I+IAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+++ALKARP + Y P+ +Y++W +V S FEY++ LI+ NT+CL + +Q TD D LN+IFTV+FT+E ILKL AF K YF D WN+FDF++V+GS VD+I+S + + ++Q G + +SI FRLFRVMRLVKLL++ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIAL + + I+RNNNFQTFP AVL+LFR ATGE W EIML C RC+ CGS A YF+SFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGP HLDEF WA+YD EA GRI+HLDVVT+L +I PPLGFG CPH AC +L+ MNMPL +DGTV FNATLFALVR LKIK +Q NEELR++IKK+WKRTS +LLDQ+IP D VTVGKFYATFLIQ+ FR + +R+ ++ Y P +I AG RS++ + L R S +L+ DE R +E
Sbjct: 12 FIMDEETLKRKQREKLKKLQATGGNPRPARSLLFLTLKNPFRKACINIVEWKPFEIIILLTIFANCVALAVFMPMPEEDTNNTNSNLESLEYIFLIIFTMECFLKIVAYGFLFHADAYLRNCWNILDFVIVTMGLFTVVVDFINSISGVEAPVEQKGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSILKSMLPLFHISLLVFFMVTIYAIIGLELFKCKMHKTCYHTGTD---------IIATGDDAQA----APCAQAGNGRRCTLNGTECRGDWPGPNNGITHFDNLGFSMLTVYQCITTQGWTDVLYWVNDAIGMEWPWLYFVTLILLGSFFILNLVLGVLCGEFTKEREKSSRSGEYQILRERQQFDEDLKGYMEWITQA-EVMDNDQEGQG------LLPLQDGSETETLYELDILNKLMFYVRHARRWNRFFRRKCRVWVKSKLFYWLVILLVFFNTLAIATEHHQQPDSLTNFQDNTNKALLSLFAVEMFLKMYAMGLPSYFMSLFNRFDCFVVSVGILELILVRMDVMSVMGISVLRCIRLLRIIKITRHWTTLSNLVASLLNSVRSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDDRVRRSNFDNFPQALITVFQILTGEGWNYVMYDGIMAHGGPAIPGILVSIYFIILFICGNYILLNVFLAIAVDNLAEAES----LTSAQKEKAEEKKRKRLLRENLPDKGEEEKALLAKKLAEQRAKIDGIPTTAKLKVDE-----FESNVNEIKDPFPPADFPGDDEEEEPEIPL--SPRPRPMADLQLKETEVPMPEASAFFLFGPQNKFRKLCHRIINATTFTNIILLFILLSSISLAAEDPIDPMSFRNQVLAYADYVFTSVFTAEIVLKMTTYGAFLHKGSFCRNSFNILDLIVVGVSLLSMGME-------SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTMLLDFMFACIGVQLFKGKFLYCTDPLKMTAEECQGTFIQHQENALHDMVVSQRLWMNSDLNFDNVLNGMLALFTVSTFEGWPDLLYKAIDSNLENMGPVYNNHIEISIFFIVYLILIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSCYFEYLMFLLIMLNTMCLGMQHCKQSDHITDLADTLNVIFTVLFTVEMILKLGAFKAKGYFGDPWNVFDFVIVVGSIVDVILSEIDAALAAQGGLYCLTGCSEVNPMQAIADSENMSVSITLFRLFRVMRLVKLLNRFEGIRNLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALLD-GTIINRNNNFQTFPQAVLLLFRCATGEGWHEIMLGCL---YGQRCDPKSEYLPGEEYT--CGSGFAILYFMSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPQHLDEFKKIWAEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLISMNMPLNSDGTVTFNATLFALVRTGLKIKTEGN-----FEQANEELRAIIKKIWKRTSMKLLDQVIPALGDDEVTVGKFYATFLIQDHFRKFMKRQ--EEYYGYRPSKKNKNTTEIQAGLRSIEEEA-APELQRAISGDLLNDEEMDRAMEESGEE 1614
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Zebrafish
Match: cacna1sb (calcium channel, voltage-dependent, L type, alpha 1S subunit, b [Source:ZFIN;Acc:ZDB-GENE-051227-1]) HSP 1 Score: 1415.21 bits (3662), Expect = 0.000e+0 Identity = 849/1726 (49.19%), Postives = 1118/1726 (64.77%), Query Frame = 1
Query: 235 LKDREGAKHRQLCSS---LKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKV--------DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN--EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVII------YMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKK--SRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND----------AKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINY-KSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVG-------------------KTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTG---TDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIP------QITAGDRSMQGQPLILGLPRRTSSELIG-DEF-KARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQF-QNLAQKSDSKPNDNKSTGSRLKPD 5223
LK ++ K ++L ++ +P R+LF + +NP R IV+ KPFE++ILLTIFANCV L + P P D+N+TN LE LE +F+VIFT+E LKII+YG L H+ AYLRN WNILDF IV +G+ T ++ I T V D+K+LRAFRVLRPLRLVSG+PSLQ+V++S++ +M PLFHI LLVFF+V IY+I+G+ELF K+H TCY TN + E+ KP +G CT G C+D W GPN GIT+FDNFG AMLTVFQ +T E WT V+YWINDA G WPWIYF+SLI+LGSFF+LNL+LGVLSGEF+KE+EK + ++Q RE ++ ++D GY EWI A+ + DG+SD + + E + + I K R R +++I ++KSK F +L +V LNT+V+ TEHH Q L +FQD AN++ +A FT EM++K+ A G YF FN+FD F+V I+E+ L ++ P+G+SV+RC RLLR+FKLT+YW SL +LV LL S+KSI SLLLL+ LFIVIFALLGMQ+FGGK+N + RSNFD+F Q++I+VFQ+LTGE+W+ MYNGI + GG G LVS+YF++L++ GN++LLNVFLAIAVDNL++ + + K K+EEE A M +++ + G P+T L + FE+ ++ K + D ++E + S PR +K +P S+FFIF NKFR CH ++ H+ F NI+L+ IL+SS+ LAAEDPI S RNK+L Y D +FTTVFTIEI LKM YG LHPG+FCRN+FN+LDL+VV V+L+S ++ + IS VKILRVLRVLRPLRAINRAKGLKHVVQC+ VA+K+IG I+LVT LL FMF+ + VQLFKG + C+D + T E C+G F+ + ++ + + R W N+ N+DNVL+GML LF ++TFEGWP +LYK+ID+Y D GP+YN G++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+++ALKARP K Y P+ +Y++W +V S FEY++ LI+ NTL L ++ QP + T D LN+IFTV+FT E I+KL AF K YF D WN+FDF++V+GS VD+++S + + + G + +SI FFRLFRV+RL+KLL++ + IR LLWTFIKSFQALP+V LLIVMLFFIYAVIGMQMFGKIAL + + I+RNNNFQTFP AVL+LFR ATGE W +IML+ D KS E CGS +A YF+SFYM+C+FL+INLFVA+IMDNFDYLT DWSILGPHHLDEF W +YD EA GRI+HLDVVT+L +I PPLGFG CPH AC +L+ MNMPL +DGTV FNATLFALVR LKIK +Q NEELR++IK +WKRTS +LLDQ+IPP D VTVGKFYATFLIQ FR + +R+ ++ Y P +I AG RS++ + L R S +LI DE +A + G + + T F L+ + PS+ + Q L QF +N + + S P+ + PD
Sbjct: 30 LKRKQREKLKKLLATGGNPRPPRTLFFFKLRNPFRKACTNIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTLESLEYIFLVIFTLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTIDTITGVQKEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSVLKSMLPLFHILLLVFFMVTIYAIMGLELFKCKMHKTCYYQGTNIIALRENEKPSPCAQAGNGRRCT-----INGTE--CRDG-----WPGPNFGITHFDNFGFAMLTVFQCITTESWTDVLYWINDAMGNDWPWIYFLSLIMLGSFFILNLVLGVLSGEFTKEREKSRSRGEWQVLRERQQMDEDLKGYMEWITHAEVM-----DGDSDAMLLLRK--------DTGSETDSLYKMEGINKVVYFYRLARRWNIVIRRKCHGWVKSKSFNWWVLIVVLLNTLVIATEHHNQTEGLTNFQDTANVILLACFTIEMIMKMYAFGPRSYFMSIFNRFDCFVVTIGILEIILVGSGIMTPLGISVMRCIRLLRLFKLTKYWTSLNNLVVSLLNSVKSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDRPIQRSNFDNFPQALISVFQVLTGEEWDTIMYNGIMAHGGPKSPGILVSIYFIILYVCGNFVLLNVFLAIAVDNLAEAESLAAAQKERAEERARKKLMKPLPEKTEEEKALMAKR---LMESRQKTEG----------MPTTAKLKIDE-----FESNVNEVKDPFPPADFPGDDEEEEP--EIPISPRPRPMADLQLKETVVPMPEASSFFIFGPQNKFRKLCHRIINHTTFTNIILLFILLSSISLAAEDPIDPHSFRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHPGSFCRNSFNILDLIVVAVSLLSMGME-------SSTISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIVLVTMLLDFMFSCIGVQLFKGTLFYCTDPLQKTAEQCQGTFLKHVQNSLHDTEIHQRRWVNSDFNFDNVLNGMLALFTISTFEGWPEILYKAIDSYDVDTGPLYNNRVGISIFFIIYIIIIAFFMMNIFVGFVIVTFQRQGEQEYKNCELDKNQRQCVQYALKARPLKCYIPENPHQYRVWYLVTSCYFEYLMFFLIMLNTLSLGMQYCNQPFYITKLSDNLNVIFTVLFTGEMIVKLIAFKAKGYFGDPWNVFDFVIVIGSIVDVVLSEVDRTLEASGGLWCLHGCSEVDPMQAIAEAENVKLSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQMFGKIALVD-GTEINRNNNFQTFPQAVLLLFRVATGEQWPKIMLASMYGKLCDPKS--------DYGPGEEYTCGSSIAVCYFLSFYMLCAFLVINLFVAIIMDNFDYLTHDWSILGPHHLDEFKKIWGEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHHAACKRLISMNMPLNSDGTVTFNATLFALVRTALKIKTEGN-----FEQANEELRAIIKSIWKRTSMKLLDQVIPPIGEDEVTVGKFYATFLIQEHFRKFMQRQ--EELYGYRPTKKNADEIKAGLRSIEEEA-APELHRAISGDLIAEDEMERAMESGEEGIYRRTGGLFGLNADPFSSEPSSPLSTQVTSQRPL-----QFAENRPEDAGSPPDSVFLPNTEFFPD 1681 HSP 2 Score: 88.1965 bits (217), Expect = 1.020e-16 Identity = 91/351 (25.93%), Postives = 150/351 (42.74%), Query Frame = 1
Query: 3505 ELSKNQRKCIE--FALKARPRKRYTP-----QGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTD----TLDILNIIFTVVFTLEFILKLSAFSF----KNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-------------GKIAL--NNTDSSISRNNN------------------------FQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
EL + QR+ ++ A PR T + R ++V K FE +IL I AN + LA F P+ T+ TL+ L IF V+FTLE LK+ A+ Y + WNI DF++V +++ + + Q K + R FRV+R ++L+S S++ ++ + +KS L ++ LL+ + IYA++G+++F IAL N S ++ N F F A+L +F+ T ESW +++ +D G+ + YF+S M+ SF I+NL + V+ F
Sbjct: 29 ELKRKQREKLKKLLATGGNPRPPRTLFFFKLRNPFRKACTNIVEWKPFEIIILLTIFANCVALAV-FLPMPEEDTNNTNLTLESLEYIFLVIFTLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTIDTITGVQKEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSVLKSMLPLFHILLLVFFMVTIYAIMGLELFKCKMHKTCYYQGTNIIALRENEKPSPCAQAGNGRRCTINGTECRDGWPGPNFGITHFDNFGFAMLTVFQCITTESWTDVL---------------------YWINDAMGNDWPWIYFLSLIMLGSFFILNLVLGVLSGEF 357
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Zebrafish
Match: cacna1da (calcium channel, voltage-dependent, L type, alpha 1D subunit, a [Source:ZFIN;Acc:ZDB-GENE-030616-135]) HSP 1 Score: 869.381 bits (2245), Expect = 0.000e+0 Identity = 489/790 (61.90%), Postives = 592/790 (74.94%), Query Frame = 1
Query: 2515 ACPRRNDVDNMKTES-QKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
A PR + +K E IP SAFFIFS+TN RV CH ++ H F N++LV I++SS LAAEDPIR S RN IL YFDY FT +FT+EI LKM YG LH GAFCRN FNLLDLLVV V+LVSF I ++ AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG IM+VT LL FMFA + VQLFKG+FY C+D +K + E CKG +I YK N P ++ R W N+ N+DNVL M+ LF V+TFEGWP LLYK+ID+ +E+ GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK W VV S FEY++ LIL NT+CLA + Q + + +DILN++FT VFT+E +LKL AF ++YF+DAWN FD ++V+GS VD I+ + + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGKIA+ + + I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C C+ CGS A YFI+FYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF W++YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR LKIK ++Q NEELR+VIKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ++FR +++RK
Sbjct: 785 AGPRPKISELVKKEKITPIPEGSAFFIFSNTNPVRVACHKLINHHIFTNLILVFIMLSSASLAAEDPIRNFSARNIILGYFDYAFTAIFTVEIVLKMTTYGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGI-------QSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPEECKGTYIMYKEGDVNQPIIQKRHWHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKFWYVVNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKPRHYFTDAWNTFDALIVVGSVVD-----IAITEVNNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVD-HTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACM---PGKLCDPESDYNPGEEMT--CGSSFAIIYFITFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGN-----LEQANEELRAVIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQDYFRKFKKRK 1551 HSP 2 Score: 634.024 bits (1634), Expect = 0.000e+0 Identity = 357/724 (49.31%), Postives = 478/724 (66.02%), Query Frame = 1
Query: 223 ALAALKDREGAKHRQLCSS--LKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIG---VVTEILTAISFNTKV-----------------DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADE---------------------LSDEENDG------NSDDYREISTSLDHNQNPEAAIEEMAKSRC-----HKILKXXXXXX-----XXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLS 2211
+LA K + AK ++ SS +P R+LFCL NP+R +V+ KPF++ IL+ IFANC+ L + P+P DSNSTN LE +E F++IFTIE LKII+YG ++HQNAY+RN WN+LDF IV+IG VV E+LT + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELF+GK+HA+CY T+ + ++P PC V G +C P++ +CK E W GPN GITNFDNF AMLTVFQ +TMEGWT V+YW+NDA G + PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A++ L +++ G +SD + + S + N E E K+ C KI K R RR+ + +KS F+ L++ LVFLNT+ + +EH+ QP+WL QD+AN V +A+FT EM++K+ +LGL YF FN+FD F+V I E L ++++P+G+SV RC RLLR+FK+T++W SL +LV LL SMKSI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F Q+++TVFQILTGEDWN MY+GI ++GG + G +V +YF++LFI GNYILLNVFLAIAVDNL+
Sbjct: 31 SLAQKKRAQYAKSKKQGSSANTRPQRALFCLNLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLIIFTIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSAHGHGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHASCYFQGTDILEDEPAPCAVN--GHGRTC----PIN---GTLCK-----EGWQGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDAMGLELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEEEESKRNRVTLASLMEKKKKGFGWFSQSSDTHASMPASETESMNTENEKGEDEKATCCGPTCQKISKSKFSRRWRRWNRLCRRNCRLAVKSVPFYWLVIILVFLNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLA 740 HSP 3 Score: 122.865 bits (307), Expect = 3.344e-27 Identity = 77/257 (29.96%), Postives = 139/257 (54.09%), Query Frame = 1
Query: 1507 MKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINP-----IGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS---RSNFDHFWQSVITVFQILTGEDWNEEM--------------YN-GIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL 2208
+ S F ++ L+ LNT+ L +H+ Q + DI N+VF A+FT EMV+K++A YF+ A+N FD IV+ S++++++T +V N I ++ R R++R+ KL +R+L+ +KS +++ + LL+ + I+A++GMQ+FG +D +NF F Q+V+ +F+ TGE W E M YN G G + +YF+ +++ ++++N+F+A+ +DN
Sbjct: 1145 VNSTGFEYIMFVLILLNTICLAVQHYGQSELFNYVMDILNMVFTAVFTVEMVLKLIAFKPRHYFTDAWNTFDALIVVGSVVDIAIT--EVNNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACMPGKLCDPESDYNPGEEMTCG----SSFAIIYFITFYMLCAFLIINLFVAVIMDNF 1395 HSP 4 Score: 112.464 bits (280), Expect = 5.028e-24 Identity = 76/274 (27.74%), Postives = 131/274 (47.81%), Query Frame = 1
Query: 295 SLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPC-----MVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMY 1101
+ F NPVR+ ++++ F LIL+ I + L P + ++ N IL + F IFT+E LK+ +YG LH+ A+ RN +N+LD +V + +V+ + + + + +K LR RVLRPLR ++ L+ V+ + A++ + +I ++ L +++ IG++LF GK + +E P+ C M GD P+ + + W D NFDN +AM+ +F T EGW ++Y
Sbjct: 808 AFFIFSNTNPVRVACHKLINHHIFTNLILVFIMLSSASLAAEDP--IRNFSARNIILGYFDYAFTAIFTVEIVLKMTTYGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSAISV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFY-----RCNDEAKSSPEECKGTYIMYKEGDVN------QPIIQKRHWHNSD--------------FNFDNVLMAMMALFTVSTFEGWPALLY 1051 HSP 5 Score: 103.605 bits (257), Expect = 2.748e-21 Identity = 145/641 (22.62%), Postives = 257/641 (40.09%), Query Frame = 1
Query: 349 VDSKPFEVLILLTIFANCVVLG---MNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWP-------WIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHN---QNPEAAIEEMAK-SRCHKILKXXXXXXXXXXXSVII----YMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIA----NIVFVALFTFEMVIKILALGL----GEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGK-YNLDKKSRS--------------------------------NFDHFWQSVITVFQILTGEDWNEEMYNGIRS 2094
V S PF L+++ +F N + + N+P ++ + V + +FT E +K+ S G AY + +N D F+V G+ IL + + I R R+LR ++ SL ++ S++ +MK + + LL+F ++I+S++GM++F GK + DE Q T+R + FDNF A+LTVFQ +T E W VMY + Y P IYF+ L + G++ +LN+ L + + +A+ N D + I DE+ DE G D+ + P I E+ K + I + V + + F LIL + L++ L E P+ S ++I + F A+FT E+V+K+ G G + FN DL +V S++ + + + +LR R+LR + L+ +V+ + ++++I +++++ L +FA +G+Q+F GK Y + +++S NFD+ +++ +F + T E W +Y I S
Sbjct: 504 VKSVPFYWLVIILVFLNTLTISSEHYNQPM------WLTQVQDVANKVLLAMFTCEMLVKMYSLGL----QAYFVSLFNRFDCFVVCGGITETILVEFEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQVFGGKFN----------------------------------FDETQ---------TKR--------STFDNFPQALLTVFQILTGEDWNAVMY--DGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLA----------------DAESLNTDDTKKPDEI---DEIEDEAKAGEEDEKDNAEEDEEEPDVPAGPRPKISELVKKEKITPIPEGSAFFIFSNTNPVRVACHKLINHHIFTNLILVFIMLSSASLAAE---DPIRNFSARNIILGYFDYAFTAIFTVEIVLKMTTYGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGIQSSAISV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCNDEAKSSPEECKGTYIMYKEGDVNQPIIQKRHWHNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDS 1056 HSP 6 Score: 94.3597 bits (233), Expect = 1.475e-18 Identity = 89/355 (25.07%), Postives = 155/355 (43.66%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNT----KVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ----------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G K + C K R C+E K P+R +I + +V+S FE ++ + I N + L + G S N +++ L +VF +FT+E LK+I++ Y +AWN D IV+ VV +T ++ NT ++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK ++ +D Q I ++N NF F A+L +F+ T E W ++M + G + IYF++ +L +F ++NL + V+ F
Sbjct: 1101 QGEKEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNPYQYKFWYVVNSTGFEYIMFVLILLNTICLAVQH---YGQSELFNYVMDILNMVFTAVFTVEMVLKLIAF----KPRHYFTDAWNTFDALIVVGSVVDIAITEVN-NTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVF-GK---------------------------------IAMVDHTQ--INRNN--------------NFQTFPQAVLLLFRCATGEAWQEIMLACMPGKLCDPESDYNPGEEMTCGSSFAIIYFITFYMLCAFLIINLFVAVIMDNF 1395 HSP 7 Score: 89.3521 bits (220), Expect = 5.779e-17 Identity = 68/281 (24.20%), Postives = 135/281 (48.04%), Query Frame = 1
Query: 3589 RYKMWSVVCSKK---------FEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIM---LSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
R++ W+ +C + F ++++ L+ NTL +++ QP + T D+ N + +FT E ++K+ + + YF +N FD VV G + I+ I S + I+ FR R++R+ K+ S+ L+ + + S +++ + LL+ + I++++GMQ+FG N D + ++ + F FP A+L +F+ TGE W +M + G S + YFI ++ +++++N+F+A+ +DN
Sbjct: 488 RWRRWNRLCRRNCRLAVKSVPFYWLVIILVFLNTLTISSEHYNQPMWLTQVQDVANKVLLAMFTCEMLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVEFEIMSP--------LGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQVFG--GKFNFDETQTKRSTFDNFPQALLTVFQILTGEDWNAVMYDGIMAYGGPSSS-------------------GMIVCIYFIILFICGNYILLNVFLAIAVDNL 739 HSP 8 Score: 77.411 bits (189), Expect = 2.003e-13 Identity = 81/324 (25.00%), Postives = 138/324 (42.59%), Query Frame = 1
Query: 3586 LRYKMWSVVCSKKFEYVILSLILANTLCLAA--RFDQQPKFYTD-TLDILNIIFTVVFTLEFILKLSAFSF----KNYFSDAWNIFDF-IVVLGSY-----------VDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GKI-------------------ALNNTDSSISRNN---------------NFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
+R S+V K F+ IL I AN + LA F + T+ L+ + F ++FT+E LK+ A+ Y + WN+ DF IVV+G + + N+S+ GK + R FRV+R ++L+S S++ +L + IK+ L ++ALL++ + IYA+IG+++F GK+ A+N + N NF F A+L +F+ T E W +++ +D G + + YF+S + SF ++NL + V+ F
Sbjct: 67 IRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLIIFTIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSAHGHGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHASCYFQGTDILEDEPAPCAVNGHGRTCPINGTLCKEGWQGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLY---------------------WMNDAMGLELPWVYFVSLVIFGSFFVLNLVLGVLSGEF 369 HSP 9 Score: 64.6994 bits (156), Expect = 1.776e-9 Identity = 80/293 (27.30%), Postives = 133/293 (45.39%), Query Frame = 1
Query: 2572 PYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRT--SSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEA-----ISA-----------VKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPL-----------------NYDNVLSGMLTLFVVATFEGWPGLLYKSIDA 3345
P A F + N R C ++V F +L+ I + + LA P S+ N L +Y F +FTIE LK+IAYG ++H A+ RN +N+LD ++V + L S ++++ + +SA VK LR RVLRPLR ++ L+ V+ ++ A+ + I L+ ++ ++A++ ++LF G+ ++ +C Q + + P N P+ N+DN + MLT+F T EGW +LY DA
Sbjct: 54 PQRALFCLNLNNPIRRACISLVEWKPFDIFILIAIFANCMALAVYVPFPEDDSNSTNHDLETVEYAFLIIFTIETFLKIIAYGLVMHQNAYVRNGWNMLDFVIVVIGLFSVVLEVLTKEGGEKEEVGENLSAHGHGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHA----------SCYFQGTDILEDEPAPCAVNGHGRTCPINGTLCKEGWQGPNGGITNFDNFMFAMLTVFQCITMEGWTDVLYWMNDA 336
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Xenopus
Match: CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:NCBI gene;Acc:100488055]) HSP 1 Score: 1491.48 bits (3860), Expect = 0.000e+0 Identity = 858/1587 (54.06%), Postives = 1119/1587 (70.51%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEIL---------TAISF-NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCY---NNVTNEMMED-PKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIE-----EMAKSRC-----HKILKXXXXXX-----XXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK--KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND----------AKCKNNKSEEENAEMVDNQDGMVKD--EKLANGGV-GDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQ-VGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
K + ++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL +AI D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCY N + + E+ P PC + ++G C +C+ WVGP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ P +YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D + D+ + + S+ ++ + ++ + C H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN V +ALFT EM++K+ +LGL YF FN+FD FIV I+E L ++++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F Q+++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + A+ + + ++EN + + V++ EK+ + D S N TK + + NE+ +EK Y + EE E V PR ++K ++ +P SAFF+F N+FRV CH +V ++ F N++L IL+SS+ LAAEDP+R +S RN++L YFD +FT +FT+EI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ YSC+DSSK+T CKG++I YK + P + +R+WEN+ ++DNVLS M+ LF V+TFEGWP LLY++ID++ ED GP+YN+ ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS VD+I+S TN+S S Q V + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C + + + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR +L IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 97 KKQGTTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGGSAIGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYYLTNGYPDVLTEEEPSPCALE-SNNGRHCP--------NGTLCRSG-----WVGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPCVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEDIDEEKPRNMSMPTSETESVNTDNVGSGDVEEESCGVRLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPDWLTEVQDTANKVLLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETRIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMLTRRSTFDNFPQALLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQENESLGKSPVPAVEENKEKIELKAITADGESPPN--------TKISVEEFSTNEN-EEKTPYPSSNETPGEEEEEEPEMPVGPR-PRPLSELHIKEKAAPMPEASAFFVFRSDNRFRVHCHRIVNNNIFTNLILFFILLSSISLAAEDPVRHNSFRNQVLFYFDIVFTAIFTVEIVLKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYSCTDSSKITEAECKGKYITYKDGDVSQPMIVDRSWENSKFDFDNVLSAMMALFTVSTFEGWPELLYRAIDSHTEDVGPIYNHRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCSFKEAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSVVDVILSETNVSISGQNVEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPSKPCA--------PESETSEEKCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTSLCIKTDGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1638 HSP 2 Score: 96.6709 bits (239), Expect = 4.522e-19 Identity = 90/359 (25.07%), Postives = 152/359 (42.34%), Query Frame = 1
Query: 241 DREGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTA---------ISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWI-------------NDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S S + L ++F +FT+E LK+I++ Y + WN+ DF IVI VV IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W ++M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1183 QEQGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCSFKEAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSVVDVILSETNVSISGQNVEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQEIMLACLPSKPCAPESETSEEKCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1482
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Xenopus
Match: CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:NCBI gene;Acc:100488055]) HSP 1 Score: 1486.09 bits (3846), Expect = 0.000e+0 Identity = 854/1587 (53.81%), Postives = 1115/1587 (70.26%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEIL---------TAISF-NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCY---NNVTNEMMED-PKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIE-----EMAKSRC-----HKILKXXXXXX-----XXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK--KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND----------AKCKNNKSEEENAEMVDNQDGMVKD--EKLANGGV-GDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXX-XXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
K + ++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL +AI D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCY N + + E+ P PC + ++G C +C+ WVGP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ P +YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D + D+ + + S+ ++ + ++ + C H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN V +ALFT EM++K+ +LGL YF FN+FD FIV I+E L ++++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F Q+++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + A+ + + ++EN + + V++ EK+ + D S N TK + + NE+ +EK Y + EE E V PR ++K ++ +P SAFF+F N+FRV CH +V ++ F N++L IL+SS+ LAAEDP+R +S RN++L YFD +FT +FT+EI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ YSC+DSSK+T CKG++I YK + P + +R+WEN+ ++DNVLS M+ LF V+TFEGWP LLY++ID++ ED GP+YN+ ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + + ++ILN++FT +FT+E ILKL AF K+YF DAWN FD ++V+GS VDI I+ N+S+ V + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C + + + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR +L IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 131 KKQGTTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGGSAIGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYYLTNGYPDVLTEEEPSPCALE-SNNGRHCP--------NGTLCRSG-----WVGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPCVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEDIDEEKPRNMSMPTSETESVNTDNVGSGDVEEESCGVRLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPDWLTEVQDTANKVLLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETRIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMLTRRSTFDNFPQALLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQENESLGKSPVPAVEENKEKIELKAITADGESPPN--------TKISVEEFSTNEN-EEKTPYPSSNETPGEEEEEEPEMPVGPR-PRPLSELHIKEKAAPMPEASAFFVFRSDNRFRVHCHRIVNNNIFTNLILFFILLSSISLAAEDPVRHNSFRNQVLFYFDIVFTAIFTVEIVLKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYSCTDSSKITEAECKGKYITYKDGDVSQPMIVDRSWENSKFDFDNVLSAMMALFTVSTFEGWPELLYRAIDSHTEDVGPIYNHRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCSFKEAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITELNVSNPRLSVTENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPSKPCA--------PESETSEEKCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTSLCIKTDGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1672 HSP 2 Score: 90.8929 bits (224), Expect = 2.659e-17 Identity = 87/359 (24.23%), Postives = 152/359 (42.34%), Query Frame = 1
Query: 241 DREGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT---------AISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWI-------------NDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S S + L ++F +FT+E LK+I++ Y +AWN D IV+ +V +T +++ N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W ++M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1217 QEQGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCSFKEAMNILNMLFTGLFTVEMILKLIAF----KPKHYFCDAWNTFDALIVVGSIVDIAITELNVSNPRLSVTENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQEIMLACLPSKPCAPESETSEEKCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1516
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Xenopus
Match: frrs1l (ferric-chelate reductase 1-like [Source:Xenbase;Acc:XB-GENE-6257538]) HSP 1 Score: 1483 bits (3838), Expect = 0.000e+0 Identity = 836/1597 (52.35%), Postives = 1074/1597 (67.25%), Query Frame = 1
Query: 352 DSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAIS--------FNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEM--MEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLD-HNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKH-FENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIP-SVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXX------XXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTG---TDEKSRCEIXXXXXXXXXXHDF-------CGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKK 5049
+ +PFE++ILLTIFANC+ L + P P D+NS N ILEK+E +F+ IFTIEA+LKI++YGF+LH +AYLRN WNILDF IV +G+ T +L I+ T ++K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+I+G ELF GK+H TCY T+ + +E P PC S TG +G+ + W GPN+GIT+FDNFG AMLTV+Q +TMEGWT+V+YW+NDA G +WPWIYFVSLILLGSFFVLNL+LGVLSGEF+KE+EK + FQK RE + ++D GY +WI A+ + + G+ D ++ + + H+Q+ E H++L+R + +KS+ F+ ++ ++ NT+ + TEHH QP WL QDIAN V +A+FT EMV+KI ALG YF FN+FD F+V I+E+ L +++P+G+SVLRC RLLR+FK+T+YW SL +LV LL S++SI SLLLL+ LF++IFALLGMQMFGGK++ + RS FD+F QS+ITVFQILTGEDWN MYNGI ++GG G V +YF++LF+ GNYILLNVFLAIAVDNL+ E EN + K A H T+K++++ H + N S E + S PR +K ++ +P S+FFIF TNKFRV CH +V + F N +L+ IL+SS+ LAAEDPI S RN+IL YFDY+FT +FT EI LKM YG LH G+FCRN FN+LDLLVV V+LVSF I ++ AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+K+IG I+LVT LL FMF+ + VQLFKG+FYSC+D++K+T E C+G FI K + + R W ++ ++DNVLSGM++LF ++TFEGWP LLY++ID++ ED GP+YNY +A+F++ YII+IAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+++ALKARP +RY P+ +YK+W +V S FEY++ +LI+ NT+ L + Q ++ DILN+ FT +FT+E +LKL+AF K YF D WN+FDF++V+GS +D+I+S T + T ISI FFRLFRVMRLVKLLS+ + +R LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIA+ + + I+RNNNFQTFP AVLVLFR ATGE+WQEI+L+C+ D KS DF CG+ AY YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG CPH AC +LV MNMPL +DGTV FNATLF+LVR LKIK +Q NEELR +IKK+WKRTS +LLDQ+IPP D VTVGKFYA FLIQ FR +++R+ + G R + + RT E + E + G E+E ++
Sbjct: 54 EYRPFEMIILLTIFANCIALAIYLPMPEDDTNSVNTILEKIEYIFLFIFTIEAALKIVAYGFILHSDAYLRNCWNILDFTIVSVGLFTIVLEQINKVQGVTAPGGTGFNVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFMIIIYAIVGKELFSGKMHKTCYYKATDVIATVEKPSPC---------STTG-----QGRQCAINGSECRGWWPGPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFVLNLVLGVLSGEFTKEREKAKSRGAFQKLREQQAMDEDLRGYLDWITHAEVMDPDMEQGDEDPAQKNTRCGNGHDQSCERCGTGKQWRHWHRLLRRKCRDL----------VKSRFFYWFVILIILFNTITIATEHHNQPEWLTKAQDIANQVLLAMFTLEMVLKIYALGFQSYFMSLFNRFDCFVVCTGILEILLVSSNIMSPLGISVLRCIRLLRIFKITRYWTSLNNLVASLLNSVRSIASLLLLLFLFMIIFALLGMQMFGGKFDFEDTEIRRSTFDNFPQSLITVFQILTGEDWNSVMYNGIMAYGGPTFPGMFVCIYFIILFVCGNYILLNVFLAIAVDNLA-------------------EAENLTSAQKAKAEERKRKKLKPMKKSAAKKIQH------TSKNLLQIHAWRNISSLEP-------------------EIPISPRPRPLAELQLKEKAVPMPDASSFFIFGPTNKFRVLCHRIVNATTFTNFILLFILLSSISLAAEDPIEPESFRNQILAYFDYVFTAIFTTEIALKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLVSFGI-------QSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTTLLQFMFSCIGVQLFKGKFYSCTDTTKMTEEECRGYFIVAKDGDSTQIQLRERIWTHSDFHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHSEDMGPIYNYRIEIAVFFIIYIILIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLRRYIPKNQHQYKIWYLVTSSYFEYLMFALIMLNTISLGMQHYGQTAEFSHLSDILNVAFTGIFTVEMVLKLAAFKAKGYFGDPWNVFDFLIVIGSIIDVILSEIDVIWGTFNIVTPGSEDTSRISITFFRLFRVMRLVKLLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAMVD-GTQINRNNNFQTFPQAVLVLFRCATGEAWQEILLACSYGKLCDPKS---------------DFLPGEEYTCGTSFAYFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVSMNMPLNSDGTVTFNATLFSLVRTALKIKTEGN-----FEQSNEELRMIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYAIFLIQEHFRKFKKRQ----------EEYYGYRPKKNNKYVFQAGLRTVEEEVEPEMQRAISGDLTAEEELER 1544 HSP 2 Score: 208.764 bits (530), Expect = 2.600e-53 Identity = 180/682 (26.39%), Postives = 309/682 (45.31%), Query Frame = 1
Query: 286 PD-RSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIY---------FVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFF-ILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVI--------------NPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS---RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGV-------------NGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL 2208
PD S F N R+ RIV++ F ILL I + + L P + N+IL + VF IFT E +LK+ +YG LH+ ++ RN +NILD +V + +V+ + + + + +K LR RVLRPLR ++ L+ V+ + A+K + +I L+ L ++S IG++LF GK + +C + T +M E+ + DG D Q L ER +D +FDN M+++F T EGW Q++Y D+ IY F+ I+L +FF++N+ +G + F ++ E+ + + K +RQ Y + R + + NQ+ I Y+ + +F L+ +L+ LNT+ L +H+ Q DI N+ F +FT EMV+K+ A YF +N FD IV+ SII++ L+ VI + I ++ R R++R+ KL +R+L+ +KS +++ + LL+ + I+A++GMQ+FG +D +NF F Q+V+ +F+ TGE W E + S+G + + YF+ +++ ++++N+F+A+ +DN
Sbjct: 739 PDASSFFIFGPTNKFRVLCHRIVNATTFTNFILLFILLSSISLAAEDPIEP--ESFRNQILAYFDYVFTAIFTTEIALKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLVSFGIQSSAISV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTTLLQFMFSCIGVQLFKGKFY-SCTD--TTKMTEEECRGYFIVAKDG---------DSTQI------QLRERIWTHSD--FHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHSEDMGPIYNYRIEIAVFFIIYIILIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN---QRQCVQY---------------------ALKARPLRRYIPKNQHQYK----------------------------IWYLVTSSYFEYLMFALIMLNTISLGMQHYGQTAEFSHLSDILNVAFTGIFTVEMVLKLAAFKAKGYFGDPWNVFDFLIVIGSIIDVILSEIDVIWGTFNIVTPGSEDTSRISITFFRLFRVMRLVKLLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAMVDGTQINRNNNFQTFPQAVLVLFRCATGEAWQEILLAC--SYGKLCDPKSDFLPGEEYTCGTSFAYFYFISFYMLCAFLIINLFVAVIMDNF 1341
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Xenopus
Match: frrs1l (ferric-chelate reductase 1-like [Source:Xenbase;Acc:XB-GENE-6257538]) HSP 1 Score: 1481.46 bits (3834), Expect = 0.000e+0 Identity = 838/1577 (53.14%), Postives = 1087/1577 (68.93%), Query Frame = 1
Query: 355 SKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAIS--------FNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEM--MEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR-CHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIP-SVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTG---TDEKSRCEIXXXXXXXXXXHDF-------CGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIP-----QITAGDRSMQGQPLILGLPRRTSSELIGDE 4998
++PFE++ILLTIFANC+ L + P P D+NS N ILEK+E +F+ IFTIEA+LKI++YGF+LH +AYLRN WNILDF IV +G+ T +L I+ T ++K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+I+G ELF GK+H TCY T+ + +E P PC S TG +G+ + W GPN+GIT+FDNFG AMLTV+Q +TMEGWT+V+YW+NDA G +WPWIYFVSLILLGSFFVLNL+LGVLSGEF+KE+EK + FQK RE + ++D GY +WI A+ + + G D+ + SL + I + + R H++L+R + +KS+ F+ ++ ++ NT+ + TEHH QP WL QDIAN V +A+FT EMV+KI ALG YF FN+FD F+V I+E+ L +++P+G+SVLRC RLLR+FK+T+YW SL +LV LL S++SI SLLLL+ LF++IFALLGMQMFGGK++ + RS FD+F QS+ITVFQILTGEDWN MYNGI ++GG G V +YF++LF+ GNYILLNVFLAIAVDNL++ + N + K+EE K +KLA + + P+ + ++ F + + ++ E+ + S PR +K ++ +P S+FFIF TNKFRV CH +V + F N +L+ IL+SS+ LAAEDPI S RN+IL YFDY+FT +FT EI LKM YG LH G+FCRN FN+LDLLVV V+LVSF I ++ AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+K+IG I+LVT LL FMF+ + VQLFKG+FYSC+D++K+T E C+G FI K + + R W ++ ++DNVLSGM++LF ++TFEGWP LLY++ID++ ED GP+YNY +A+F++ YII+IAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+++ALKARP +RY P+ +YK+W +V S FEY++ +LI+ NT+ L + Q ++ DILN+ FT +FT+E +LKL+AF K YF D WN+FDF++V+GS +D+I+S ++SS T ISI FFRLFRVMRLVKLLS+ + +R LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIA+ + + I+RNNNFQTFP AVLVLFR ATGE+WQEI+L+C+ D KS DF CG+ AY YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG CPH AC +LV MNMPL +DGTV FNATLF+LVR LKIK +Q NEELR +IKK+WKRTS +LLDQ+IPP D VTVGKFYA FLIQ FR +++R+ ++ Y P +I AG R+++ + + + R S +L +E
Sbjct: 8 TEPFEMIILLTIFANCIALAIYLPMPEDDTNSVNTILEKIEYIFLFIFTIEAALKIVAYGFILHSDAYLRNCWNILDFTIVSVGLFTIVLEQINKVQGVTAPGGTGFNVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFMIIIYAIVGKELFSGKMHKTCYYKATDVIATVEKPSPC---------STTG-----QGRQCAINGSECRGWWPGPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFVLNLVLGVLSGEFTKEREKAKSRGAFQKLREQQAMDEDLRGYLDWITHAEVMDPDMEQG--DEGCSETESLYELEGINKFISFLKQWRHWHRLLRRKCRDL----------VKSRFFYWFVILIILFNTITIATEHHNQPEWLTKAQDIANQVLLAMFTLEMVLKIYALGFQSYFMSLFNRFDCFVVCTGILEILLVSSNIMSPLGISVLRCIRLLRIFKITRYWTSLNNLVASLLNSVRSIASLLLLLFLFMIIFALLGMQMFGGKFDFEDTEIRRSTFDNFPQSLITVFQILTGEDWNSVMYNGIMAYGGPTFPGMFVCIYFIILFVCGNYILLNVFLAIAVDNLAEAE------NLTSAQKAKAEER------------KRKKLAR--------LQSTPNIEQFLSTVTLKNAFVSIYCDDEE---------------EEPEIPISPRPRPLAELQLKEKAVPMPDASSFFIFGPTNKFRVLCHRIVNATTFTNFILLFILLSSISLAAEDPIEPESFRNQILAYFDYVFTAIFTTEIALKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLVSFGI-------QSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTTLLQFMFSCIGVQLFKGKFYSCTDTTKMTEEECRGYFIVAKDGDSTQIQLRERIWTHSDFHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHSEDMGPIYNYRIEIAVFFIIYIILIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLRRYIPKNQHQYKIWYLVTSSYFEYLMFALIMLNTISLGMQHYGQTAEFSHLSDILNVAFTGIFTVEMVLKLAAFKAKGYFGDPWNVFDFLIVIGSIIDVILSEIDVSSE----DTSRISITFFRLFRVMRLVKLLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAMVD-GTQINRNNNFQTFPQAVLVLFRCATGEAWQEILLACSYGKLCDPKS---------------DFLPGEEYTCGTSFAYFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVSMNMPLNSDGTVTFNATLFSLVRTALKIKTEGN-----FEQSNEELRMIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYAIFLIQEHFRKFKKRQ--EEYYGYRPKKNNVEIQAGLRTVE-EEVEPEMQRAISGDLTAEE 1482 HSP 2 Score: 210.69 bits (535), Expect = 7.343e-54 Identity = 179/672 (26.64%), Postives = 308/672 (45.83%), Query Frame = 1
Query: 286 PD-RSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIY---------FVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFF-ILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKV----INPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS---RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGV-------------NGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL 2208
PD S F N R+ RIV++ F ILL I + + L P + N+IL + VF IFT E +LK+ +YG LH+ ++ RN +NILD +V + +V+ + + + + +K LR RVLRPLR ++ L+ V+ + A+K + +I L+ L ++S IG++LF GK + +C + T +M E+ + DG D Q L ER +D +FDN M+++F T EGW Q++Y D+ IY F+ I+L +FF++N+ +G + F ++ E+ + + K +RQ Y + R + + NQ+ I Y+ + +F L+ +L+ LNT+ L +H+ Q DI N+ F +FT EMV+K+ A YF +N FD IV+ SII++ L+ V + I ++ R R++R+ KL +R+L+ +KS +++ + LL+ + I+A++GMQ+FG +D +NF F Q+V+ +F+ TGE W E + S+G + + YF+ +++ ++++N+F+A+ +DN
Sbjct: 692 PDASSFFIFGPTNKFRVLCHRIVNATTFTNFILLFILLSSISLAAEDPIEP--ESFRNQILAYFDYVFTAIFTTEIALKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLVSFGIQSSAISV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTTLLQFMFSCIGVQLFKGKFY-SCTD--TTKMTEEECRGYFIVAKDG---------DSTQI------QLRERIWTHSD--FHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHSEDMGPIYNYRIEIAVFFIIYIILIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKN---QRQCVQY---------------------ALKARPLRRYIPKNQHQYK----------------------------IWYLVTSSYFEYLMFALIMLNTISLGMQHYGQTAEFSHLSDILNVAFTGIFTVEMVLKLAAFKAKGYFGDPWNVFDFLIVIGSIIDVILSEIDVSSEDTSRISITFFRLFRVMRLVKLLSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAMVDGTQINRNNNFQTFPQAVLVLFRCATGEAWQEILLAC--SYGKLCDPKSDFLPGEEYTCGTSFAYFYFISFYMLCAFLIINLFVAVIMDNF 1284 HSP 3 Score: 149.058 bits (375), Expect = 4.773e-35 Identity = 171/645 (26.51%), Postives = 298/645 (46.20%), Query Frame = 1
Query: 2638 CHSYFGNIVLVCILVSSVMLAAEDPIRT--SSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISA----VKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGR-----FYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLN----YDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGE------------------------------SEYKNCELSKNQRKC---------------IEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDN 4392
C F I+L+ I + + LA P+ ++ N IL +YIF +FTIE LK++AYGF+LH A+ RN +N+LD +V V L + ++ + + A VK LR RVLRPLR ++ L+ V+ ++ A+ + I L+ ++ ++A++ +LF G+ +Y +D + I E R W P N +DN MLT++ T EGW +LY DA ++ +Y +V+ I++ +FF++N+ +G + F KE E +E + ++ + C I F + R R LR K +V S+ F + ++ +IL NT+ +A QP++ T DI N + +FTLE +LK+ A F++YF +N FD VV ++I++ +NI S + I+ R R++R+ K+ S+ L+ + + S +++ + LL+ + I+A++GMQMFG + D+ I R + F FP +++ +F+ TGE W +M + F G +V YFI ++ +++++N+F+A+ +DN
Sbjct: 7 CTEPFEMIILLTIFANCIALAIYLPMPEDDTNSVNTILEKIEYIFLFIFTIEAALKIVAYGFILHSDAYLRNCWNILDFTIVSVGLFTIVLEQINKVQGVTAPGGTGFNVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFMIIIYAIVGKELFSGKMHKTCYYKATDVIATVEKPSPCSTTGQGRQCAINGSECRGWWPGPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIY---------FVSLILLGSFFVLNLVLGVLSGEFTKEREKAKSRGAFQKLREQQAMDEDLRGYLDWITHAEVMDPDMEQGDEGCSETESLYELEGINKFISFLKQWRHWHRL-----LRRKCRDLVKSRFFYWFVILIILFNTITIATEHHNQPEWLTKAQDIANQVLLAMFTLEMVLKIYALGFQSYFMSLFNRFDCFVVCTGILEILLVSSNIMSP--------LGISVLRCIRLLRIFKITRYWTSLNNLVASLLNSVRSIASLLLLLFLFMIIFALLGMQMFGG-KFDFEDTEI-RRSTFDNFPQSLITVFQILTGEDWNSVMYN---------------GIMAYGGPTFPGMFVCI-YFIILFVCGNYILLNVFLAIAVDN 611 HSP 4 Score: 83.5741 bits (205), Expect = 4.265e-15 Identity = 79/307 (25.73%), Postives = 141/307 (45.93%), Query Frame = 1
Query: 3613 CSKKFEYVILSLILANTLCLAARFDQQPKFYTDT----LDILNIIFTVVFTLEFILKLSAFSF----KNYFSDAWNIFDF-IVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GKI------------------------------ALNNTDSS---ISRNN---NFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
C++ FE +IL I AN + LA + P+ T++ L+ + IF +FT+E LK+ A+ F Y + WNI DF IV +G + ++ + + G T F ++ R FRV+R ++L+S S++ +L + IK+ L ++ALL++ + IYA++G ++F GK+ A+N ++ NN +F F A+L +++ T E W E++ +D G+ + YF+S ++ SF ++NL + V+ F
Sbjct: 7 CTEPFEMIILLTIFANCIALAI-YLPMPEDDTNSVNTILEKIEYIFLFIFTIEAALKIVAYGFILHSDAYLRNCWNILDFTIVSVGLFTIVLEQINKVQGVTAPGGTGF-NVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFMIIIYAIVGKELFSGKMHKTCYYKATDVIATVEKPSPCSTTGQGRQCAINGSECRGWWPGPNNGITHFDNFGFAMLTVYQCITMEGWTEVL---------------------YWVNDAIGNEWPWIYFVSLILLGSFFVLNLVLGVLSGEF 290
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Xenopus
Match: CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:NCBI gene;Acc:100488055]) HSP 1 Score: 1479.54 bits (3829), Expect = 0.000e+0 Identity = 856/1603 (53.40%), Postives = 1113/1603 (69.43%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEIL---------TAISF-NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCY---NNVTNEMMED-PKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSD----------EENDGNSDDYREISTSLDHNQNPEAAIE----------EMAKSRC-----HKILKXXXXXX-----XXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK--KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND----------AKCKNNKSEEENAEMVDNQDGMVKD--EKLANGGV-GDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXX--XXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
K + ++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL +AI D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCY N + + E+ P PC + ++G C + +C+ WVGP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ P +YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ + + S + I S P + E ++ + C H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN V +ALFT EM++K+ +LGL YF FN+FD FIV I+E L ++++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F Q+++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + A+ + + ++EN + + V++ EK+ + D S N TK + + NE+ +EK Y + EE E V PR ++K ++ +P SAFF+F N+FRV CH +V ++ F N++L IL+SS+ LAAEDP+R +S RN++L YFD +FT +FT+EI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ YSC+DSSK+T CKG++I YK + P + +R+WEN+ ++DNVLS M+ LF V+TFEGWP LLY++ID++ ED GP+YN+ ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + + ++ILN++FT +FT+E ILKL AF K+YF DAWN FD ++V+GS VDI I+ N+S S V + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C + + + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR +L IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 96 KKQGTTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGGSAIGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYYLTNGYPDVLTEEEPSPCALE-SNNGRHCPNGT--------LCRSG-----WVGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPCVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEDIDEEKPRNSMSCAHMIIHASSASMSMPTSETESVNTDNVGSGDVEEESCGVRLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPDWLTEVQDTANKVLLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETRIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMLTRRSTFDNFPQALLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQENESLGKSPVPAVEENKEKIELKAITADGESPPN--------TKISVEEFSTNEN-EEKTPYPSSNETPGEEEEEEPEMPVGPR-PRPLSELHIKEKAAPMPEASAFFVFRSDNRFRVHCHRIVNNNIFTNLILFFILLSSISLAAEDPVRHNSFRNQVLFYFDIVFTAIFTVEIVLKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYSCTDSSKITEAECKGKYITYKDGDVSQPMIVDRSWENSKFDFDNVLSAMMALFTVSTFEGWPELLYRAIDSHTEDVGPIYNHRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCSFKEAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITELNVSNPRLSNVEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPSKPCA--------PESETSEEKCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTSLCIKTDGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1653 HSP 2 Score: 90.8929 bits (224), Expect = 2.817e-17 Identity = 89/360 (24.72%), Postives = 153/360 (42.50%), Query Frame = 1
Query: 241 DREGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVV----TEI------LTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWI-------------NDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S S + L ++F +FT+E LK+I++ Y +AWN D IV+ +V TE+ L+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W ++M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1197 QEQGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCSFKEAMNILNMLFTGLFTVEMILKLIAF----KPKHYFCDAWNTFDALIVVGSIVDIAITELNVSNPRLSNVEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQEIMLACLPSKPCAPESETSEEKCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1497
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Mouse
Match: Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:MGI Symbol;Acc:MGI:103013]) HSP 1 Score: 1516.52 bits (3925), Expect = 0.000e+0 Identity = 862/1579 (54.59%), Postives = 1102/1579 (69.79%), Query Frame = 1
Query: 274 SSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNN---VTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN + EDP PC + G G C +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD FIV I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+++ V++ K + + P T + D+ + ENE D E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL YFD +FTT+FTIEI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 126 TATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGH-GRQCQ--------NGTVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKP--AVEESKEEKIELKSITADGESPPTTKINMDDL--QPSENEDKSPHSNPDTAGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1665 HSP 2 Score: 86.6557 bits (213), Expect = 4.004e-16 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT--------------AISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1202 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1509
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Mouse
Match: Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:MGI Symbol;Acc:MGI:103013]) HSP 1 Score: 1514.98 bits (3921), Expect = 0.000e+0 Identity = 861/1579 (54.53%), Postives = 1103/1579 (69.85%), Query Frame = 1
Query: 274 SSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNN---VTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN + EDP PC + G G C + +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+NDA G WPWIYFV+LI++GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD FIV I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+++ V++ K + + P T + D+ + ENE D E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL DY+FT++FT+EI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 96 TATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGH-GRQCQNGT--------VCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKP--AVEESKEEKIELKSITADGESPPTTKINMDDL--QPSENEDKSPHSNPDTAGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635 HSP 2 Score: 86.2705 bits (212), Expect = 4.804e-16 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT--------------AISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1172 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Mouse
Match: Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:MGI Symbol;Acc:MGI:103013]) HSP 1 Score: 1513.05 bits (3916), Expect = 0.000e+0 Identity = 860/1579 (54.46%), Postives = 1099/1579 (69.60%), Query Frame = 1
Query: 274 SSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNN---VTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN + EDP PC + G G C +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD FIV I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+++ V++ K + + P T + D+ + ENE D E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL YFD +FTT+FTIEI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K+YF DAWN FD ++V+GS VDI I+ + + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 126 TATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGH-GRQCQ--------NGTVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKP--AVEESKEEKIELKSITADGESPPTTKINMDDL--QPSENEDKSPHSNPDTAGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1665 HSP 2 Score: 81.2629 bits (199), Expect = 1.777e-14 Identity = 86/367 (23.43%), Postives = 148/367 (40.33%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAI--------------SFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y +AWN D IV+ +V +T + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1202 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1509
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Mouse
Match: Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:MGI Symbol;Acc:MGI:103013]) HSP 1 Score: 1511.51 bits (3912), Expect = 0.000e+0 Identity = 859/1579 (54.40%), Postives = 1101/1579 (69.73%), Query Frame = 1
Query: 274 SSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNN---VTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN + EDP PC + G G C +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD FIV I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+++ V++ K + + P T + D+ + ENE D E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL DY+FT++FT+EI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 96 TATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGH-GRQCQ--------NGTVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKP--AVEESKEEKIELKSITADGESPPTTKINMDDL--QPSENEDKSPHSNPDTAGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635 HSP 2 Score: 86.6557 bits (213), Expect = 4.164e-16 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT--------------AISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1172 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Mouse
Match: Cacna1c (calcium channel, voltage-dependent, L type, alpha 1C subunit [Source:MGI Symbol;Acc:MGI:103013]) HSP 1 Score: 1511.51 bits (3912), Expect = 0.000e+0 Identity = 859/1579 (54.40%), Postives = 1101/1579 (69.73%), Query Frame = 1
Query: 274 SSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNN---VTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN + EDP PC + G G C +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD FIV I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+++ V++ K + + P T + D+ + ENE D E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL DY+FT++FT+EI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 96 TATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGH-GRQCQ--------NGTVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKP--AVEESKEEKIELKSITADGESPPTTKINMDDL--QPSENEDKSPHSNPDTAGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635 HSP 2 Score: 86.6557 bits (213), Expect = 4.164e-16 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT--------------AISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1172 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. UniProt/SwissProt
Match: sp|Q24270|CAC1D_DROME (Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster OX=7227 GN=Ca-alpha1D PE=1 SV=2) HSP 1 Score: 1580.46 bits (4091), Expect = 0.000e+0 Identity = 901/1679 (53.66%), Postives = 1150/1679 (68.49%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLG-DDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEE-----NDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS---RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYX-XXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKS---HKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGK---------------TKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPK-DSDTVTVGKFYATFLIQNWFRDWQRRK--------------MIQKDIRYIPQIT-AGDRSMQG---------QPLILGLPRRTSSELIGDEFKA-RKKGTQNDEKETKKDFSLSTKRLITPPSNQAI-----SNPVLQSSLPNGG 5142
+P R+LFCL KNP+R RIV+ KPFE LILLTIFANC+ L + PYP DSN TN+ LEK+E VF+VIFT E +KI++YGF+LH AYLRN WN+LDF IV+IG ++ L+ + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSI+ AM PLFHIALLV F+++IY+IIG+ELF GKLH C + +T E E+ +PC VG GY C G W GPNDGITNFDNFGLAMLTVFQ +T+EGWT V+Y I DA G W W+YF+S+++LG+FFV+NLILGVLSGEFSKE+ K + FQK RE ++ +D GY +WI +A+++ + +DG E+ ++ N E +M +SR K+ K F + R RR+ +KS+ F+ LI+ LVFLNT VL TEH+ Q WLD+FQ+ N+ F+ LFT EM++K+ +LG YF FN+FD F+V+ SI E LT ++ P+G+SVLRC RLLRVFK+T+YW SL +LV LL S++SI SLLLL+ LFIVIFALLGMQ+FGGK+N D K R NFD FWQ+++TVFQI+TGEDWN MY GI ++GGV+ GAL +YF++LFI GNYILLNVFLAIAVDNL+D D E + + + +++++ DGM D+ L+ DM ++ ++E + E E EE D + + +A PRR N T+ IPP ++FF+FS TN+FRVFCH + HS FGNI+L CI+ SS MLAAE+P+R + NK+LN FDY FT VFTIE+ LK+I+YGF+LH GAFCR+ FNLLDLLV + ++ + AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV+VAVK+IG I+LVT LL FMFAV+ VQLFKG+F+ C+D SK+T + C G ++ Y HK P + R W NN ++D+V GMLTLF V+TFEGWPGLLY SID+ KE+ GP++N+ VA +Y+ YIIIIAFFM+NIFVGFVIVTFQ EGE EYKNC+L KNQR CIEFALKA+P +RY P+ ++YK+W V S FEY I LI+ NT+ LA +F QP +YT+ LD LN+IFT VF LEF+ KL+AF FKNYF DAWN+FDFI+VLGS++DI+ S +SQ+ + + ISINFFRLFRVMRLVKLLSK + IR LLWTFIKSFQALPYVALLIV+LFFIYAV+GMQ+FGKIAL+ + +I+ NNNFQTF AVLVLFRSATGE+WQEIM+SC+ + +C++ + + CGS +AYPYFISFY++CSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFI W++YD +AKGRI+HLDVVT+L KISPPLGFG +CPH AC +LV MNMPL +DGTVLFNATLFA+VR +L IK +D N ELR+ IK++WKRT+P+LLDQ++PP + D VTVGKFYAT+LIQ++FR +++RK +Q +R + +++ A R++ G +P+ R L G + + R+ G + K S S L S A S+ VL SS P GG
Sbjct: 590 RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQL-MKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYG-------------------GWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDST--ENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGM--DDHLS-------------------IDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLV-------VCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHK--PRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGN-AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPD-VKCDMNSDTPG-----EPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGN-----IDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPM-----HRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGG 2199 HSP 2 Score: 120.168 bits (300), Expect = 1.951e-25 Identity = 98/329 (29.79%), Postives = 158/329 (48.02%), Query Frame = 1
Query: 280 LKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPL-DEGQSWICKDNNLTER-WVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLIL---------LGSFFVLNLILGVLSGEFSKEKEK 1233
+ P S F + N R+F + + F +IL I + +L P A D N++L K + F +FTIE LK+ISYGF+LH A+ R+A+N+LD +V V+ I S N +K LR RVLRPLR ++ L+ V+ +I A+K + +I L+ L ++++IG++LF GK C + ++M +D C G + D+G L ER W ++ +FD+ MLT+F T EGW ++Y D+ I+ I+ + +FF++N+ +G + F E E+
Sbjct: 1318 IPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDD--LNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVV---CVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFF-KCTDG--SKMTQD-------------ECYGTYLVYDDGD---VHKPRLREREW---SNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQ 1619 HSP 3 Score: 82.0333 bits (201), Expect = 6.907e-14 Identity = 88/376 (23.40%), Postives = 150/376 (39.89%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGM---NRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAI-----------------------SFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWIN---------------DAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
EG + + C K R+ C+E K PVR +I + V S FE I + I N V L M N+P +L+ L ++F +F +E K+ ++ F Y +AWN+ DF IV+ + + + I + + + I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY+++GM++F GK+ LD G + I +N NF F A+L +F++ T E W ++M + + G + YF+S +L SF ++NL + V+ F
Sbjct: 1616 EGEQEYKNCDLDKNQRN--CIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPL------WYTELLDALNMIFTAVFALEFVFKLAAFRF----KNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVF-GKI----------------------------------ALDGGNA-ITANN--------------NFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 1929
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. UniProt/SwissProt
Match: sp|Q25452|CAC1M_MUSDO (Muscle calcium channel subunit alpha-1 OS=Musca domestica OX=7370 PE=2 SV=1) HSP 1 Score: 1580.07 bits (4090), Expect = 0.000e+0 Identity = 874/1568 (55.74%), Postives = 1118/1568 (71.30%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDP---KPCMVGLG-DDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEEN-----DGNSDDYREIST--SLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNL---DKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEM-VDNQ--DGMVKDEKLANGG-------VGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQV-----------GKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
+P+R+LFCL KNP+RIF +IVDSK FE ILLTIFANCV L + PYP+GDSN TN++LEK+E +F+VIFT E +KII+YGF+LH +YLRN WN LDFFIV+IG+++ L+ + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSI+ AM PL HIALLV F+++IY+IIG+ELF GKLH TC ++ T E + D C VG GY C + WVGPNDGITNFDNFGL+MLTVFQ +T+EGWT V+Y I DA G W WIYFVS+++LG+FFV+NLILGVLSGEFSKE+ K + FQK RE ++ +D GY +WI +A+++ + + D + + +E+ + +L ++N + +S+ + + R+ R R++V KS+ F+ LI+ LVFLNT VL TEH++QP+WLD FQ+ NI F+ALFT EM++K+ +LG YF FN+FD F+V+ SI E+ LT +++ P+G+SVLRC RLLRVFK+T+YW+SL +LV LL S++SI SLLLL+ LFIVIF LLGMQ+FGG++ ++K RSNFD F+QS++TVFQILTGEDWN MY+GIR++GGV G + +Y+++LFI GNYILLNVFLAIAVDNL+ DA + +E+ +++ +DNQ + M +E L NG G CG + D E++ K G K+ S+ PRRN +M + IP ++FFIFS TN+FR+FCH + HS FGN +L CI+ SS MLAAE+P++ + RN +LN FDY FT VFTIE+ LK+I+YGF+LH GAFCR+ FNLLDLLVV + ++ + + AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV+VAVK+IG I+LVT LL FMFAV+ VQLFKG+F+SCSD SK+ C G ++ Y++ N P ++ R W+NN ++D+V MLTLF V+TFEGWP LLY SID+ KE+ GP+YN+ VA +Y+ YIIIIAFFM+NIFVGFVIVTFQ EGE EYKNCEL KNQR CIEFALKA+P +RY P+ ++YK+W V S FEY I LI+ NT+ LA +F +QP++Y++ LD LN+IFT VF+LEFI KL+AF FKNYF DAWN FDFI+VLGS++DI+ S + G + ISINFFRLFRVMRLVKLLSK + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKI L +SI RNNNFQTFP AVLVLFRSATGE+WQEIM++C+ D+ +C+ + CGS +A+PYFISFY++CSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFI W++YD +AKGRI+HLDVVT+L KISPPLGFG +CPH AC +LV MNMPL +DGTVLFNATLFA+VR L IK +D+ N ELR+ IK++WKRT+P+LLDQ++ + D VTVGKFYAT+LIQ++FR +++RK
Sbjct: 36 RPERALFCLTLKNPLRIFCIKIVDSKLFEYFILLTIFANCVALAVYTPYPSGDSNITNQMLEKIEYIFLVIFTSECVMKIIAYGFVLHTGSYLRNGWNFLDFFIVVIGMISTALSNL-VKEGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMIPLLHIALLVLFVIIIYAIIGLELFSGKLHKTCRHSNTGEYLNDLDELHACGVGFKCPSGYECF-------------------DDWVGPNDGITNFDNFGLSMLTVFQCITLEGWTDVLYSIQDAMGSSWEWIYFVSMVILGAFFVMNLILGVLSGEFSKERTKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDPDAQIIEDCHKNKVKEVVSIDNLKDHENETQQTDSWFRSQKKYLERINRRIRRACRKAV----KSQAFYWLIILLVFLNTGVLATEHYRQPIWLDQFQEYTNIFFIALFTCEMILKMYSLGFQGYFVSLFNRFDCFVVIGSISEMVLTSSELMAPLGVSVLRCVRLLRVFKVTKYWHSLSNLVASLLNSIQSIASLLLLLFLFIVIFGLLGMQVFGGRFTFKPEEEKPRSNFDSFYQSLLTVFQILTGEDWNVVMYDGIRAYGGVFSFGIVACIYYIILFICGNYILLNVFLAIAVDNLA----------DADSLSTIEKEDESQIQLDNQIKNEMENEEYLQNGDHISFKAEFGADLDTYLQDEECGSYSDD--------ENTYNKLGGV---------------KQRVSSLPRRNTNTDMDRIKKDIPYGTSFFIFSHTNRFRIFCHRLCNHSNFGNFILCCIMFSSAMLAAENPLKADASRNIVLNKFDYFFTAVFTIELVLKLISYGFVLHDGAFCRSAFNLLDLLVV-------CVSLISIFFNSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKGKFFSCSDGSKVYESDCHGTYLFYENGDINKPRLKEREWKNNKFHFDDVAKAMLTLFTVSTFEGWPTLLYVSIDSNKENGGPIYNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCELDKNQRNCIEFALKAKPVRRYIPKHSIQYKVWWFVTSSSFEYSIFVLIMINTVTLAMKFYKQPEYYSEILDALNMIFTAVFSLEFIFKLAAFRFKNYFGDAWNTFDFIIVLGSFIDIVYSEIKTKEQALATCDGQSCNKAKGGSTLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIMLEE-GTSIDRNNNFQTFPQAVLVLFRSATGEAWQEIMMACSPRDD-VKCDPESDAVNN------CGSSIAFPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRLPLAIKTDGN-----IDEANAELRATIKQIWKRTNPRLLDQVVLTGNDDEVTVGKFYATYLIQDYFRRFKKRK 1526
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. UniProt/SwissProt
Match: sp|P15381|CAC1C_RABIT (Voltage-dependent L-type calcium channel subunit alpha-1C OS=Oryctolagus cuniculus OX=9986 GN=CACNA1C PE=1 SV=1) HSP 1 Score: 1513.05 bits (3916), Expect = 0.000e+0 Identity = 868/1591 (54.56%), Postives = 1107/1591 (69.58%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYN-----NVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQD-GMVKDEKLANGGVGDACSIT---NHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
K + ++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN +V E +DP PC + G G C +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD FIV I+E L KV++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+V K+EK+ + SIT P T + D+ + E+E + E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL YFD +FTT+FTIEI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 120 KKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGVADVPAE--DDPSPCALETGH-GRQCQ--------NGTVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKVMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVVGKPALEEAKEEKI------ELKSITADGESPPTTKINMDDL--QPNESEDKSPYPNPETTGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1665 HSP 2 Score: 85.8853 bits (211), Expect = 4.195e-15 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAIS--------------FNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1202 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPHNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1509
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. UniProt/SwissProt
Match: sp|Q01815|CAC1C_MOUSE (Voltage-dependent L-type calcium channel subunit alpha-1C OS=Mus musculus OX=10090 GN=Cacna1c PE=1 SV=1) HSP 1 Score: 1511.51 bits (3912), Expect = 0.000e+0 Identity = 859/1579 (54.40%), Postives = 1101/1579 (69.73%), Query Frame = 1
Query: 274 SSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISF----------NTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNN---VTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSR----------CHKILKXXXXX-----XXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD--KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL-------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKT------KFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRK 4878
++ +P R+L CL KNP+R IV+ KPFE++ILLTIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TCYN + EDP PC + G G C +CK W GP GITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E D D+ + + S+ ++ E +A H+I K RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD AN +ALFT EM++K+ +LGL YF FN+FD FIV I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D + RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL S +EEEE K S E+ E+++ V++ K + + P T + D+ + ENE D E+EEE G + PR ++K ++ +P SAFFIFS N+FR+ CH +V + F N++L IL+SS+ LAAEDP++ +S RN IL DY+FT++FT+EI LKM AYG LH G+FCRN FN+LDLLVV V+L+SF I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+ Y+CSDSSK T CKG +I YK + + P ++ R+WEN+ ++DNVL+ M+ LF V+TFEGWP LLY+SID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ LIL NT+CLA + Q + ++ILN++FT +FT+E ILKL AF K YFSD WN+FDF++V+GS +D+I+S TN + +Q + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIALN+T + I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C +C + + CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR++IKK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK
Sbjct: 96 TATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGH-GRQCQ--------NGTVCKPG-----WDGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNMSMPTSETESVNTENVAGGDIEGENCGARLAHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKKQEVMEKP--AVEESKEEKIELKSITADGESPPTTKINMDDL--QPSENEDKSPHSNPDTAGEEDEEEPEMPVGPR-----PRPLSELHLKEKAVPMPEASAFFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDT-TEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEGN-----LEQANEELRAIIKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRK 1635 HSP 2 Score: 86.6557 bits (213), Expect = 2.913e-15 Identity = 87/367 (23.71%), Postives = 150/367 (40.87%), Query Frame = 1
Query: 247 EGAKHRQLCSSLKPDRSLFCLE---KKNPVRIFIAR---------IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT--------------AISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ------------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+G + + C K R C+E K P+R +I + +V+S FE L+ + I N + L M G S + L ++F +FT+E LK+I++ Y + WN+ DF IVI ++ IL+ + N+++ I R FRV+R ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ N+ T I ++N NF F A+L +F+ T E W +M + G + YF+S +L +F ++NL + V+ F
Sbjct: 1172 QGEQEYKNCELDKNQRQ--CVEYALKARPLRRYIPKNQHQYKVWYVVNSTYFEYLMFVLILLNTICLAMQH---YGQSCLFKIAMNILNMLFTGLFTVEMILKLIAF----KPKGYFSDPWNVFDFLIVIGSIIDVILSETNPAEHTQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVF-GKI---ALNDTTE--------------------------------INRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. UniProt/SwissProt
Match: sp|Q02485|CAC1S_RAT (Voltage-dependent L-type calcium channel subunit alpha-1S OS=Rattus norvegicus OX=10116 GN=Cacna1s PE=1 SV=2) HSP 1 Score: 1494.17 bits (3867), Expect = 0.000e+0 Identity = 853/1619 (52.69%), Postives = 1102/1619 (68.07%), Query Frame = 1
Query: 283 KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAI-----------SFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN--EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHN-QNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKN-----------NKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIP-SVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQV--------------GKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIP-----QITAGDRSMQGQPLILGLPRRTSSELIGDE 4998
+P R+LFCL +NP+R +V+ KPFE +ILLTIFANCV L + P P D+N+ N LEKLE F+++F+IEA++KII+YGFL HQ+AYLR+ WN+LDF IV +GV T IL + S +D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSI AM PLFHIALLV F+V+IY+IIG+ELF GK+H TCY T+ +E+ KP G CT + W GPN GIT+FDNFG +MLTV+Q ++MEGWT V+YW+NDA G +WPWIYFV+LILLGSFF+LNL+LGVLSGEF+KE+EK + FQK RE ++ +D GY WI + + + + DD RE SLD + E+ E ++ + ++ +R+ +R +KSK F+ L++ +V LNT+ + +EHH QPLWL QD+AN V +ALFT EM++K+ LGL +YF FN+FD F+V I+E+ L + P+G+SVLRC RLLR+FK+T+YW SL +LV LL S++SI SLLLL+ LF++IFALLGMQ+FGG+Y+ + RSNFD+F Q++I+VFQ+LTGEDWN MYNGI ++GG + G LV +YF++LF+ GNYILLNVFLAIAVDNL++ + AK + +KSEEE + M + K E + P+T L + FE+ ++ K Y D ++E + S PR +K ++ IP S+FFIFS TNK RV CH +V ++F N +L+ IL+SS LAAEDPIR S RN+IL YFDY+FT VFT+EI LKM YG LH G+FCRN FN+LDLLVV V+L+S ++ + AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I+LVT LL FMFA + VQLFKG+FYSC+D SK+T E C+G + YK + R W +N ++DNVLS M++LF V+TFEGWP LLYK+ID+ +ED GPVYN +AIF++ YII+IAFFM+NIFVGFVIVTFQ++GE+EYKNCEL KNQR+C+++ALKARP + Y P+ +Y++W VV S FEY++ +LI+ NT+CL + Q + DILN+ FT++FTLE ILKL AF + YF D WN+FDF++V+GS +D+I+S + +S ++ IS FFRLFRVMRL+KLLS+ + +R LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIA+ + + I+RNNNFQTFP AVL+LFR ATGE+WQEI+L+C+ RC+ CG+ AY YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG CPH AC +LV MNMPL +DGTV FNATLFALVR LKIK +Q NEELR++IKK+WKRTS +LLDQ+IPP D VTVGKFYATFLIQ FR + +R+ ++ Y P QI AG R+++ + + R S +L +E
Sbjct: 26 RPPRALFCLTLQNPLRKACISVVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNIIQTNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSGRPCT------------INGSECRGGWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQKLREKQQLEEDLRGYMSWITQGEVM-------DVDDLREGKLSLDEGGSDTESLYEIEGLNKIIQFIRHWRQWNRVFRWKCHDLVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTHLQDVANRVLLALFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFMIIFALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTS-AQKAKAEERKRRKMSRGLPDKSEEERSTMTKKLEQKPKGEGI--------------PTTAKLKIDE-----FESNVNEVKDPYPSADFPGDDEEDEP--EIPASPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQILEYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLE-------SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFYSCNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMVD-GTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACS---YGKRCDPESDYAPGEEYA--CGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTALKIKTEGN-----FEQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQ--EEYYGYRPKKDTVQIQAGLRTIE-EEAAPEIHRAISGDLTAEE 1582 HSP 2 Score: 83.5741 bits (205), Expect = 2.088e-14 Identity = 84/346 (24.28%), Postives = 151/346 (43.64%), Query Frame = 1
Query: 3514 KNQRKCIEFALKARPRKRY--TPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDI----LNIIFTVVFTLEFILKLSAFSF----KNYFSDAWNIFDFIVV-LGSY--VDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GKI--------------ALNNTDSSISRNN------------------------NFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
K +K + L PR + T Q LR SVV K FE +IL I AN + LA + P+ +TL++ L F +VF++E +K+ A+ F Y WN+ DFI+V LG + + ++ +++ K + + R FRV+R ++L+S S++ +L + K+ L ++ALL++ + IYA+IG+++F GK+ N S +R +F F ++L +++ + E W +++ +D G+ + YF++ ++ SF I+NL + V+ F
Sbjct: 14 KQPKKPVPEILPRPPRALFCLTLQNPLRKACISVVEWKPFETIILLTIFANCVALAV-YLPMPEDDNNTLNLGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNIIQTNTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTCYFIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCISMEGWTDVL---------------------YWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEF 337
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. TrEMBL
Match: G0YP31 (Voltage-dependent L-type calcium channel subunit alpha OS=Dugesia japonica OX=6161 PE=2 SV=1) HSP 1 Score: 2912.87 bits (7550), Expect = 0.000e+0 Identity = 1520/1700 (89.41%), Postives = 1603/1700 (94.29%), Query Frame = 1
Query: 109 MTSTGSTLYTASSQNPWKXXXXXXXXX-XXXNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCK-NNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXG-KKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNK 5196
MTSTGSTLYT S+QNPWKS +GGG+A GTGNRPFIADLALAALKDREGAK RQLC+S KPDRSLFCL+KKN +R+FIARIVDSKPFE+LIL TIFANCVVLGMNRPYP DSNSTN+ILEKLE+VFV+IFT E+ LKIISYGF+LH N+YLRNAWNILDFFIV+IG+VTE L S KVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNE+MEDPKPCMVG+ D+GY+C+G+ LD+GQSW+C++ N +ERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQG KWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKE FQKERE KRQ QDY+GYKEWIEKADELSDEENDGNSDDYREI+ SLDHNQN EAAIEE+AKSRCHK+LKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNT+VL TEHHKQP+WLD FQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFD F+VLCSIIELSLTRPK+INPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNL+KKSRSNFDHFWQS+ITVFQILTGEDWNEEMYNGIRSFGGV GLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDD+EEEE NDAK K NNKSE+ENAEMVDNQD + KDEKL NG VGD I N+ +T L+ + IR HFE++++Q+KR Y+E+ EEEEEF N+D K+ SACPRRND++NMKTESQ IPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTI+ NEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSC+D+SKLTN+TCKGQFINYK + NIP+VENRTWENN LNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKED+GPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYK+WS+VCSKKFEYVILSLILANT+CLAARFDQQPK YT+TLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIIS+ N +SS QVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNN+DS+ISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKS CE ++EH CGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRI+HLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQ+DGTVLFNATLFALVRRNLKIKIPA+DDKK MDQWNEELR+VIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQ+DIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFK +KKG QND+KETKKD S+STKRLITPPSNQAISNPVLQS++PNGGIQFQ QKSD K N+NK
Sbjct: 1 MTSTGSTLYTTSAQNPWKSASGGGAASFGTGNRPFIADLALAALKDREGAKRRQLCTSFKPDRSLFCLKKKNVLRVFIARIVDSKPFEILILFTIFANCVVLGMNRPYPNNDSNSTNKILEKLELVFVIIFTFESLLKIISYGFILHPNSYLRNAWNILDFFIVLIGLVTEFLAWTSVEAKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEIMEDPKPCMVGVVDEGYTCSGIGSLDDGQSWVCREYNASERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGNKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKELFQKERELKRQQQDYIGYKEWIEKADELSDEENDGNSDDYREINASLDHNQNAEAAIEEIAKSRCHKLLKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNTLVLTTEHHKQPIWLDRFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDFFVVLCSIIELSLTRPKIINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLEKKSRSNFDHFWQSIITVFQILTGEDWNEEMYNGIRSFGGVKGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDDEEEEEGNDAKSKNNNKSEDENAEMVDNQDAVSKDEKLPNGSVGDNNCI-NNSNTGALSKMERIRMHFESDNTQDKRTYEEIYAEEEEEFFNDDDLKRGASACPRRNDLENMKTESQTIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTIE-------NEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCTDNSKLTNDTCKGQFINYKGLRGNIPTVENRTWENNALNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDFGPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKIWSMVCSKKFEYVILSLILANTICLAARFDQQPKPYTETLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIISKANTNSSPQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNSDSAISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSHCE------PGTNEHGLCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIKHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQSDGTVLFNATLFALVRRNLKIKIPADDDKKSMDQWNEELRAVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQRDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKVKKKGIQNDDKETKKDLSISTKRLITPPSNQAISNPVLQSTIPNGGIQFQKSVQKSDPKINENK 1686 HSP 2 Score: 238.81 bits (608), Expect = 3.318e-59 Identity = 114/143 (79.72%), Postives = 126/143 (88.11%), Query Frame = 1
Query: 5590 SLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPRSVRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPETSNNYRKSYPVEDIGNEHSRHYLGSPLSYSEDEVKMAREMFAAARKESLKPNI 6018
S+ S+ N N+ + PHSE+IDFKYGDLVGDDPH+NTG+MSMLPRSVRIS+T+MGMSANHEIKTPIVFMQ+QALAMAGMPIKPET+N YRKSYPVED NEHSR YLGSP+SYSEDEVKMAREMFAAARKESLKPNI
Sbjct: 1674 SVQKSDPKINENKPNT----RPHSEKIDFKYGDLVGDDPHSNTGLMSMLPRSVRISSTAMGMSANHEIKTPIVFMQHQALAMAGMPIKPETTNYYRKSYPVEDPTNEHSRGYLGSPVSYSEDEVKMAREMFAAARKESLKPNI 1812
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. TrEMBL
Match: A0A4V3SGT9 (Voltage-dependent L-type calcium channel subunit alpha OS=Opisthorchis felineus OX=147828 GN=CRM22_001369 PE=3 SV=1) HSP 1 Score: 1835.85 bits (4754), Expect = 0.000e+0 Identity = 1012/1653 (61.22%), Postives = 1246/1653 (75.38%), Query Frame = 1
Query: 142 SSQNPWKXXX---XXXXXXXXXNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN--EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQ-NPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNL--DKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTE-SQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL----NNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCT-------GTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDK--KPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQND 5031
SQNPW S A G+AF + NRP IADLALAALK+R + +++C + DRSLF + KKNP+R IVD+KPF+ IL+ I NC+ L N PYP DSN+ N++LEK+E+ FV+IFT E++LKII+YGF+LH AYLR WNILDF IV++G+ +++L T D+K+LRAFRVLRPLRL+SGLPSLQ+VLNSIITAM PL HIALLV F++++Y+IIG+EL KLH+TCYN T EMM +PKPC G+ C+ + P ++ C D +R+ GP GI +FDNF L+MLTVF +TMEGWT Y++ DA G+ WPWIY V+LILLGSFFV+NL+LGVLSGEFSKEKEKIDR F+KER+AKR+ QDYLGYKEWIE A+ELSD E + S + E T+ + Q PE ++E+ K+ CH L+RFRK R R RR+VI ++ S+Q F LI+ LVFLNT+VL TEHH QP WLD FQD AN VFVALFT EM+IKI A GL +YFSK FN+FD F+V+ SI+EL L +V++P+G+SVLRCARLLR+FKLTQYW SLRSLV KLLKS++S+ SLLLL+ +FI+I +LLGMQ+FGG++N ++K R+NFD Q+++TVFQILTGEDWNE MY G++++ + G +V +YF+ LFIVGNYILLNVFLAIAVDNL+DDDDE+EE N A K + E+ E ++ D+ LA+G V PS D K +E E E Y + G+ D ++D N + S+ +PP+SAFFIFSDTNKFR+FCHNVVC S+FGNIVLVCILVSS++LAAEDP+ + S RNKILN FDY FT+VFT+EITLKMI+YGF+LH GAFCR+ FNLLDL+VV VALVSF + +++ ISAVKILRVLRVLRPLRAINRAKGLKHVVQC+++A+KSIG I+LVTFLL FMF V+ VQLFKG+F+SC+D SK T CKGQFI+Y+ + P + R W N+ ++DNV + +LTLF VATFEGWP LL+ SID+ +EDYGP+ NY VA+FY+TYI++I FFMINIFVGFVIVTFQ+EGESEYKNCEL+KNQRKCIE+ALKARPR+RY P+GHL+YK+WSVV SKKFE I I NT+ L ++D Q K + LD LN FT +FT+EF+L+LSAFSF++YFSD WN+ DFI+VLGSY+D I + S V TKF S+NF RLFRVMRLVKLLSKE+SIR+LLWTFIKS QALPYVALLI M+FFIYAVIGMQ+FG+I++ + + R+NNFQ F A+LVLFR +TGE+WQ+IML+CT G+DEK CGS +AY YFISF+ I +FL+INLFVAVIMDNFDYLTRDWSILGPHHLDEF+T+WADYD EAKGR+RHLDVVTMLGKISPPLGFG+MCPHTRACHKLVRMNMPL +DGTV FNATLFALVRRNLKIKIP ED + K +DQ NEELR VIK++WKRTSP+LLDQIIPPK SD VTVGKFYATFLIQNWFR+WQ++KMIQ+D RYIPQI AGDR+M QP I+G PRR SS+L GDE + R+ + D
Sbjct: 5 GSQNPWGSAAVGGTTGNAFLSSNRPVIADLALAALKERGEVQKKRICPQFRTDRSLFFMTKKNPIRRICINIVDAKPFDYFILVAILCNCLALAFNHPYPNDDSNAVNQVLEKVELAFVIIFTTESALKIIAYGFILHPGAYLRTFWNILDFSIVLVGLSSKVLEG----TSADVKALRAFRVLRPLRLLSGLPSLQVVLNSIITAMVPLLHIALLVIFVIIVYAIIGLELLQSKLHSTCYNTTTPKYEMMANPKPCTNESSASGFKCSEIGP-----NFQCLDYP-PDRYPGPQRGIISFDNFLLSMLTVFVCVTMEGWTSTGYYVTDAVGHWWPWIYLVTLILLGSFFVMNLVLGVLSGEFSKEKEKIDRTLLFRKERQAKREQQDYLGYKEWIEVAEELSDSEGEDKSSEDLESGTATELAQAEPEVHVDEVVKTHCHSTLRRFRKLRKRTRRAVIAFINSRQCFALIIILVFLNTVVLTTEHHNQPKWLDEFQDFANKVFVALFTMEMLIKIAASGLTDYFSKLFNRFDFFVVIFSIMELLLVNFRVLDPMGVSVLRCARLLRIFKLTQYWESLRSLVGKLLKSVRSVASLLLLLFIFILICSLLGMQLFGGRFNFTEEEKPRANFDGILQAMLTVFQILTGEDWNEVMYAGMKAYENTHWYGVVV-IYFIFLFIVGNYILLNVFLAIAVDNLNDDDDEDEEGNGADTKK-EPEQPTDEAKQEEETNSNDKGLADGVVVK----VEEPSA------DDANKTYE-EMFPETDIYGDE------------GEGADDNGENQDDQKNFSAQDSRTMPPHSAFFIFSDTNKFRIFCHNVVCLSHFGNIVLVCILVSSILLAAEDPLNSQSYRNKILNMFDYFFTSVFTVEITLKMISYGFILHEGAFCRSAFNLLDLIVVCVALVSFVL-------QSQTISAVKILRVLRVLRPLRAINRAKGLKHVVQCMIIAIKSIGNIVLVTFLLEFMFGVIGVQLFKGKFWSCTDISKRTASECKGQFIDYEDMNLSKPILMERQWNNSDFHFDNVPNALLTLFTVATFEGWPKLLFTSIDSNEEDYGPITNYRPVVALFYITYIVLIPFFMINIFVGFVIVTFQREGESEYKNCELNKNQRKCIEYALKARPRRRYIPKGHLQYKIWSVVVSKKFEIFIFVCIFINTVALTLKYDGQRKEWGKLLDSLNYFFTAIFTVEFVLRLSAFSFRHYFSDVWNVVDFILVLGSYLD------IILTQSDVKVTKF-SVNFVRLFRVMRLVKLLSKEESIRQLLWTFIKSIQALPYVALLIAMIFFIYAVIGMQLFGQISIKEEPGEEEPILHRSNNFQDFFHALLVLFRCSTGEAWQDIMLACTAGRACAEGSDEKGTKS--------------CGSNLAYLYFISFHAISAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFVTKWADYDPEAKGRVRHLDVVTMLGKISPPLGFGSMCPHTRACHKLVRMNMPLNSDGTVFFNATLFALVRRNLKIKIPGEDKEKDKSLDQLNEELRLVIKRIWKRTSPKLLDQIIPPKGSDVVTVGKFYATFLIQNWFREWQKKKMIQRDTRYIPQIMAGDRAMPHQPTIVGFPRRCSSDLTGDEIQRRRGADKRD 1594
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. TrEMBL
Match: A0A4S2MB03 (Voltage-dependent L-type calcium channel subunit alpha OS=Opisthorchis felineus OX=147828 GN=CRM22_001369 PE=3 SV=1) HSP 1 Score: 1835.85 bits (4754), Expect = 0.000e+0 Identity = 1012/1653 (61.22%), Postives = 1246/1653 (75.38%), Query Frame = 1
Query: 142 SSQNPWKXXX---XXXXXXXXXNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN--EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQ-NPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNL--DKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTE-SQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL----NNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCT-------GTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDK--KPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQND 5031
SQNPW S A G+AF + NRP IADLALAALK+R + +++C + DRSLF + KKNP+R IVD+KPF+ IL+ I NC+ L N PYP DSN+ N++LEK+E+ FV+IFT E++LKII+YGF+LH AYLR WNILDF IV++G+ +++L T D+K+LRAFRVLRPLRL+SGLPSLQ+VLNSIITAM PL HIALLV F++++Y+IIG+EL KLH+TCYN T EMM +PKPC G+ C+ + P ++ C D +R+ GP GI +FDNF L+MLTVF +TMEGWT Y++ DA G+ WPWIY V+LILLGSFFV+NL+LGVLSGEFSKEKEKIDR F+KER+AKR+ QDYLGYKEWIE A+ELSD E + S + E T+ + Q PE ++E+ K+ CH L+RFRK R R RR+VI ++ S+Q F LI+ LVFLNT+VL TEHH QP WLD FQD AN VFVALFT EM+IKI A GL +YFSK FN+FD F+V+ SI+EL L +V++P+G+SVLRCARLLR+FKLTQYW SLRSLV KLLKS++S+ SLLLL+ +FI+I +LLGMQ+FGG++N ++K R+NFD Q+++TVFQILTGEDWNE MY G++++ + G +V +YF+ LFIVGNYILLNVFLAIAVDNL+DDDDE+EE N A K + E+ E ++ D+ LA+G V PS D K +E E E Y + G+ D ++D N + S+ +PP+SAFFIFSDTNKFR+FCHNVVC S+FGNIVLVCILVSS++LAAEDP+ + S RNKILN FDY FT+VFT+EITLKMI+YGF+LH GAFCR+ FNLLDL+VV VALVSF + +++ ISAVKILRVLRVLRPLRAINRAKGLKHVVQC+++A+KSIG I+LVTFLL FMF V+ VQLFKG+F+SC+D SK T CKGQFI+Y+ + P + R W N+ ++DNV + +LTLF VATFEGWP LL+ SID+ +EDYGP+ NY VA+FY+TYI++I FFMINIFVGFVIVTFQ+EGESEYKNCEL+KNQRKCIE+ALKARPR+RY P+GHL+YK+WSVV SKKFE I I NT+ L ++D Q K + LD LN FT +FT+EF+L+LSAFSF++YFSD WN+ DFI+VLGSY+D I + S V TKF S+NF RLFRVMRLVKLLSKE+SIR+LLWTFIKS QALPYVALLI M+FFIYAVIGMQ+FG+I++ + + R+NNFQ F A+LVLFR +TGE+WQ+IML+CT G+DEK CGS +AY YFISF+ I +FL+INLFVAVIMDNFDYLTRDWSILGPHHLDEF+T+WADYD EAKGR+RHLDVVTMLGKISPPLGFG+MCPHTRACHKLVRMNMPL +DGTV FNATLFALVRRNLKIKIP ED + K +DQ NEELR VIK++WKRTSP+LLDQIIPPK SD VTVGKFYATFLIQNWFR+WQ++KMIQ+D RYIPQI AGDR+M QP I+G PRR SS+L GDE + R+ + D
Sbjct: 5 GSQNPWGSAAVGGTTGNAFLSSNRPVIADLALAALKERGEVQKKRICPQFRTDRSLFFMTKKNPIRRICINIVDAKPFDYFILVAILCNCLALAFNHPYPNDDSNAVNQVLEKVELAFVIIFTTESALKIIAYGFILHPGAYLRTFWNILDFSIVLVGLSSKVLEG----TSADVKALRAFRVLRPLRLLSGLPSLQVVLNSIITAMVPLLHIALLVIFVIIVYAIIGLELLQSKLHSTCYNTTTPKYEMMANPKPCTNESSASGFKCSEIGP-----NFQCLDYP-PDRYPGPQRGIISFDNFLLSMLTVFVCVTMEGWTSTGYYVTDAVGHWWPWIYLVTLILLGSFFVMNLVLGVLSGEFSKEKEKIDRTLLFRKERQAKREQQDYLGYKEWIEVAEELSDSEGEDKSSEDLESGTATELAQAEPEVHVDEVVKTHCHSTLRRFRKLRKRTRRAVIAFINSRQCFALIIILVFLNTVVLTTEHHNQPKWLDEFQDFANKVFVALFTMEMLIKIAASGLTDYFSKLFNRFDFFVVIFSIMELLLVNFRVLDPMGVSVLRCARLLRIFKLTQYWESLRSLVGKLLKSVRSVASLLLLLFIFILICSLLGMQLFGGRFNFTEEEKPRANFDGILQAMLTVFQILTGEDWNEVMYAGMKAYENTHWYGVVV-IYFIFLFIVGNYILLNVFLAIAVDNLNDDDDEDEEGNGADTKK-EPEQPTDEAKQEEETNSNDKGLADGVVVK----VEEPSA------DDANKTYE-EMFPETDIYGDE------------GEGADDNGENQDDQKNFSAQDSRTMPPHSAFFIFSDTNKFRIFCHNVVCLSHFGNIVLVCILVSSILLAAEDPLNSQSYRNKILNMFDYFFTSVFTVEITLKMISYGFILHEGAFCRSAFNLLDLIVVCVALVSFVL-------QSQTISAVKILRVLRVLRPLRAINRAKGLKHVVQCMIIAIKSIGNIVLVTFLLEFMFGVIGVQLFKGKFWSCTDISKRTASECKGQFIDYEDMNLSKPILMERQWNNSDFHFDNVPNALLTLFTVATFEGWPKLLFTSIDSNEEDYGPITNYRPVVALFYITYIVLIPFFMINIFVGFVIVTFQREGESEYKNCELNKNQRKCIEYALKARPRRRYIPKGHLQYKIWSVVVSKKFEIFIFVCIFINTVALTLKYDGQRKEWGKLLDSLNYFFTAIFTVEFVLRLSAFSFRHYFSDVWNVVDFILVLGSYLD------IILTQSDVKVTKF-SVNFVRLFRVMRLVKLLSKEESIRQLLWTFIKSIQALPYVALLIAMIFFIYAVIGMQLFGQISIKEEPGEEEPILHRSNNFQDFFHALLVLFRCSTGEAWQDIMLACTAGRACAEGSDEKGTKS--------------CGSNLAYLYFISFHAISAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFVTKWADYDPEAKGRVRHLDVVTMLGKISPPLGFGSMCPHTRACHKLVRMNMPLNSDGTVFFNATLFALVRRNLKIKIPGEDKEKDKSLDQLNEELRLVIKRIWKRTSPKLLDQIIPPKGSDVVTVGKFYATFLIQNWFREWQKKKMIQRDTRYIPQIMAGDRAMPHQPTIVGFPRRCSSDLTGDEIQRRRGADKRD 1594
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. TrEMBL
Match: A0A4S2MAY0 (Voltage-dependent L-type calcium channel subunit alpha OS=Opisthorchis felineus OX=147828 GN=CRM22_001369 PE=3 SV=1) HSP 1 Score: 1835.08 bits (4752), Expect = 0.000e+0 Identity = 1012/1653 (61.22%), Postives = 1246/1653 (75.38%), Query Frame = 1
Query: 142 SSQNPWKXXX---XXXXXXXXXNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN--EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQ-NPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNL--DKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTE-SQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL----NNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCT-------GTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDK--KPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQND 5031
SQNPW S A G+AF + NRP IADLALAALK+R + +++C + DRSLF + KKNP+R IVD+KPF+ IL+ I NC+ L N PYP DSN+ N++LEK+E+ FV+IFT E++LKII+YGF+LH AYLR WNILDF IV++G+ +++L T D+K+LRAFRVLRPLRL+SGLPSLQ+VLNSIITAM PL HIALLV F++++Y+IIG+EL KLH+TCYN T EMM +PKPC G+ C+ + P ++ C D +R+ GP GI +FDNF L+MLTVF +TMEGWT Y++ DA G+ WPWIY V+LILLGSFFV+NL+LGVLSGEFSKEKEKIDR F+KER+AKR+ QDYLGYKEWIE A+ELSD E + S + E T+ + Q PE ++E+ K+ CH L+RFRK R R RR+VI ++ S+Q F LI+ LVFLNT+VL TEHH QP WLD FQD AN VFVALFT EM+IKI A GL +YFSK FN+FD F+V+ SI+EL L +V++P+G+SVLRCARLLR+FKLTQYW SLRSLV KLLKS++S+ SLLLL+ +FI+I +LLGMQ+FGG++N ++K R+NFD Q+++TVFQILTGEDWNE MY G++++ + G +V +YF+ LFIVGNYILLNVFLAIAVDNL+DDDDE+EE N A K + E+ E ++ D+ LA+G V PS D K +E E E Y + G+ D ++D N + S+ +PP+SAFFIFSDTNKFR+FCHNVVC S+FGNIVLVCILVSS++LAAEDP+ + S RNKILN FDY FT+VFT+EITLKMI+YGF+LH GAFCR+ FNLLDL+VV VALVSF + +++ ISAVKILRVLRVLRPLRAINRAKGLKHVVQC+++A+KSIG I+LVTFLL FMF V+ VQLFKG+F+SC+D SK T CKGQFI+Y+ + P + R W N+ ++DNV + +LTLF VATFEGWP LL+ SID+ +EDYGP+ NY VA+FY+TYI++I FFMINIFVGFVIVTFQ+EGESEYKNCEL+KNQRKCIE+ALKARPR+RY P+GHL+YK+WSVV SKKFE I I NT+ L ++D Q K + LD LN FT +FT+EF+L+LSAFSF++YFSD WN+ DFI+VLGSY+D I + S V TKF S+NF RLFRVMRLVKLLSKE+SIR+LLWTFIKS QALPYVALLI M+FFIYAVIGMQ+FG+I++ + + R+NNFQ F A+LVLFR +TGE+WQ+IML+CT G+DEK CGS +AY YFISF+ I +FL+INLFVAVIMDNFDYLTRDWSILGPHHLDEF+T+WADYD EAKGR+RHLDVVTMLGKISPPLGFG+MCPHTRACHKLVRMNMPL +DGTV FNATLFALVRRNLKIKIP ED + K +DQ NEELR VIK++WKRTSP+LLDQIIPPK SD VTVGKFYATFLIQNWFR+WQ++KMIQ+D RYIPQI AGDR+M QP I+G PRR SS+L GDE + R+ + D
Sbjct: 5 GSQNPWGSAAVGGTTGNAFLSSNRPVIADLALAALKERGEVQKKRICPQFRTDRSLFFMTKKNPIRRICINIVDAKPFDYFILVAILCNCLALAFNHPYPNDDSNAVNQVLEKVELAFVIIFTTESALKIIAYGFILHPGAYLRTFWNILDFSIVLVGLSSKVLEG----TSADVKALRAFRVLRPLRLLSGLPSLQVVLNSIITAMVPLLHIALLVIFVIIVYAIIGLELLQSKLHSTCYNTTTPKYEMMANPKPCTNESSASGFKCSEIGP-----NFQCLDYP-PDRYPGPQRGIISFDNFLLSMLTVFVCVTMEGWTSTGYYVTDAVGHWWPWIYLVTLILLGSFFVMNLVLGVLSGEFSKEKEKIDRTLLFRKERQAKREQQDYLGYKEWIEVAEELSDSEGEDKSSEDLESGTATELAQAEPEVHVDEVVKTHCHSTLRRFRKLRKRTRRAVIAFINSRQCFALIIILVFLNTVVLTTEHHNQPKWLDEFQDFANKVFVALFTMEMLIKIAASGLTDYFSKLFNRFDFFVVIFSIMELLLVNFRVLDPMGVSVLRCARLLRIFKLTQYWESLRSLVGKLLKSVRSVASLLLLLFIFILICSLLGMQLFGGRFNFTEEEKPRANFDGILQAMLTVFQILTGEDWNEVMYAGMKAYENTHWYGVVV-IYFIFLFIVGNYILLNVFLAIAVDNLNDDDDEDEEGNGADTKK-EPEQPTDEAKQEEETNSNDKGLADGVVVK----VEEPSA------DDANKTYE-EMFPETDIYGDE------------GEGADDNGENQDDQKNFSAQDSRTMPPHSAFFIFSDTNKFRIFCHNVVCLSHFGNIVLVCILVSSILLAAEDPLNSQSYRNKILNMFDYFFTSVFTVEITLKMISYGFILHEGAFCRSAFNLLDLIVVCVALVSFVL-------QSQTISAVKILRVLRVLRPLRAINRAKGLKHVVQCMIIAIKSIGNIVLVTFLLEFMFGVIGVQLFKGKFWSCTDISKRTASECKGQFIDYEDMNLSKPILMERQWNNSDFHFDNVPNALLTLFTVATFEGWPKLLFTSIDSNEEDYGPITNYRPVVALFYITYIVLIPFFMINIFVGFVIVTFQREGESEYKNCELNKNQRKCIEYALKARPRRRYIPKGHLQYKIWSVVVSKKFEIFIFVCIFINTVALTLKYDGQRKEWGKLLDSLNYFFTAIFTVEFVLRLSAFSFRHYFSDVWNVVDFILVLGSYLD------IILTQSDVKVTKF-SVNFVRLFRVMRLVKLLSKEESIRQLLWTFIKSIQALPYVALLIAMIFFIYAVIGMQLFGQISIKEEPGEEEPILHRSNNFQDFFHALLVLFRCSTGEAWQDIMLACTAGRACAEGSDEKGTKS--------------CGSNLAYLYFISFHAISAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFVTKWADYDPEAKGRVRHLDVVTMLGKISPPLGFGSMCPHTRACHKLVRMNMPLNSDGTVFFNATLFALVRRNLKIKIPGEDKEKDKSLDQLNEELRLVIKRIWKRTSPKLLDQIIPPKGSDVVTVGKFYATFLIQNWFREWQKKKMIQRDTRYIPQIMAGDRAMPHQPTIVGFPRRCSSDLTGDEIQRRRGADKRD 1594
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. TrEMBL
Match: G7YS03 (Voltage-dependent L-type calcium channel subunit alpha OS=Clonorchis sinensis OX=79923 GN=CLF_108904 PE=3 SV=1) HSP 1 Score: 1833.15 bits (4747), Expect = 0.000e+0 Identity = 1014/1663 (60.97%), Postives = 1246/1663 (74.92%), Query Frame = 1
Query: 142 SSQNPWKXXX---XXXXXXXXXNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN--EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQ-NPEAAIEEMAKSRCHKIL----------KXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNL--DKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTE-SQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL----NNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCT-------GTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDK--KPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQND 5031
SQNPW S A G+AF + NRP IADLALAALK+R + +++C + DRSLF + KKNP+R IVD+KPF+ IL+ I NC+ L N PYP DSN+ N++LEK+E+ FV+IFT E++LKII+YGF+LH AYLR WNILDF IV++G+ +++L T D+K+LRAFRVLRPLRL+SGLPSLQ+VLNSIITAM PL HIALLV F++++Y+IIG+EL KLH+TCYN T EMM +PKPC G+ C+ + P ++ C D +R+ GP GI +FDNF L+MLTVF +TMEGWT Y++ DA G+ WPWIY V+LILLGSFFV+NL+LGVLSGEFSKEKEKIDR F+KER+AKR+ QDYLGYKEWIE A+ELSD E + S + E T+ + Q PE ++E+ K+ CH L KRFRK R R RR+VI ++ S+Q F LI+ LVFLNT+VL TEHH QP WLD FQD AN VFVALFT EM+IKI A GL +YFSK FN+FD F+V+ SI+EL L +V++P+G+SVLRCARLLR+FKLTQYW SLRSLV KLLKS++S+ SLLLL+ +FI+I +LLGMQ+FGG++N ++K R+NFD Q+++TVFQILTGEDWNE MY G++++ + G +V +YF+ LFIVGNYILLNVFLAIAVDNL+DDDDE+EE N A K + E+ E ++ D+ LA+G V PS D K +E E E Y + G+ D ++D N + S+ +PP+SAFFIFSDTNKFR+FCHNVVC S+FGNIVLVCILVSS++LAAEDP+ + S RNKILN FDY FT+VFT+EITLKMI+YGF+LH GAFCR+ FNLLDL+VV VALVSF + +++ ISAVKILRVLRVLRPLRAINRAKGLKHVVQC+++A+KSIG I+LVTFLL FMF V+ VQLFKG+F+SC+D SK T CKGQFI+Y+ + P + R W N+ ++DNV + +LTLF VATFEGWP LL+ SID+ +EDYGP+ NY VA+FY+TYI++I FFMINIFVGFVIVTFQ+EGESEYKNCEL+KNQRKCIE+ALKARPR+RY P+GHL+YK+WSVV SKKFE I I NT+ L ++D Q K + LD LN FT +FT+EF+L+LSAFSF++YFSD WN+ DFI+VLGSY+D I + S V TKF S+NF RLFRVMRLVKLLSKE+SIR+LLWTFIKS QALPYVALLI M+FFIYAVIGMQ+FG+I++ + + R+NNFQ F A+LVLFR +TGE+WQ+IML+CT G+DEK CGS +AY YFISF+ I +FL+INLFVAVIMDNFDYLTRDWSILGPHHLDEF+T+WADYD EAKGR+RHLDVVTMLGKISPPLGFG+MCPHTRACHKLVRMNMPL +DGTV FNATLFALVRRNLKIKIP ED + K +DQ NEELR VIK++WKRTSP+LLDQIIPPK SD VTVGKFYATFLIQNWFR+WQ++KMIQKD RYIPQI AGDR+M QP I+G PRR SS+L GDE + R+ + D
Sbjct: 5 GSQNPWGSAAVGGTTGNAFLSSNRPVIADLALAALKERGEVQKKRICPQFRTDRSLFFMTKKNPIRRICINIVDAKPFDYFILVAILCNCLALAFNHPYPNDDSNAVNQVLEKVELAFVIIFTTESALKIIAYGFILHPGAYLRTFWNILDFSIVLVGLSSKVLEG----TSADVKALRAFRVLRPLRLLSGLPSLQVVLNSIITAMVPLLHIALLVIFVIIVYAIIGLELLQSKLHSTCYNTTTPKYEMMANPKPCTNESSASGFKCSEIGP-----NFQCLDYP-PDRYPGPQRGIISFDNFLLSMLTVFVCVTMEGWTSTGYYVTDAVGHWWPWIYLVTLILLGSFFVMNLVLGVLSGEFSKEKEKIDRTLLFRKERQAKREQQDYLGYKEWIEVAEELSDSEGEDKSSEDLESGTATELAQAEPEVHVDEVVKTHCHSTLSIISRLSPALKRFRKLRKRTRRAVIAFINSRQCFALIIILVFLNTVVLTTEHHNQPKWLDEFQDFANKVFVALFTMEMLIKIAASGLTDYFSKLFNRFDFFVVIFSILELLLVNFRVLDPMGVSVLRCARLLRIFKLTQYWESLRSLVGKLLKSVRSVASLLLLLFIFILICSLLGMQLFGGRFNFTEEEKPRANFDGILQAMLTVFQILTGEDWNEVMYAGMKAYENTHWYGVVV-IYFIFLFIVGNYILLNVFLAIAVDNLNDDDDEDEEGNGADAKK-EPEKPVDEAKQEEETNSNDKGLADGVVAK----VEEPSA------DDANKTYE-EMFPETDIYGDE------------GEGADDNGENQDDQKNFSAQDSRTMPPHSAFFIFSDTNKFRIFCHNVVCLSHFGNIVLVCILVSSILLAAEDPLNSQSYRNKILNMFDYFFTSVFTVEITLKMISYGFILHEGAFCRSAFNLLDLIVVCVALVSFVL-------QSQTISAVKILRVLRVLRPLRAINRAKGLKHVVQCMIIAIKSIGNIVLVTFLLEFMFGVIGVQLFKGKFWSCTDISKRTASECKGQFIDYEDMNLSKPILMERQWNNSDFHFDNVPNALLTLFTVATFEGWPKLLFTSIDSNEEDYGPITNYRPVVALFYITYIVLIPFFMINIFVGFVIVTFQREGESEYKNCELNKNQRKCIEYALKARPRRRYIPKGHLQYKIWSVVVSKKFEIFIFVCIFINTVALTLKYDGQRKEWGKLLDSLNYFFTAIFTVEFVLRLSAFSFRHYFSDVWNVVDFILVLGSYLD------IILTQSDVKVTKF-SVNFVRLFRVMRLVKLLSKEESIRQLLWTFIKSIQALPYVALLIAMIFFIYAVIGMQLFGQISIKEEPGEEEPILHRSNNFQDFFHALLVLFRCSTGEAWQDIMLACTAGRACAEGSDEKGTKS--------------CGSNLAYLYFISFHAISAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFVTKWADYDPEAKGRVRHLDVVTMLGKISPPLGFGSMCPHTRACHKLVRMNMPLNSDGTVFFNATLFALVRRNLKIKIPGEDKEKDKSLDQLNEELRLVIKRIWKRTSPKLLDQIIPPKGSDVVTVGKFYATFLIQNWFREWQKKKMIQKDTRYIPQIMAGDRAMPHQPTIVGFPRRCSSDLTGDEIQRRRGADKRD 1604
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Cavefish
Match: cacna1db (calcium channel, voltage-dependent, L type, alpha 1D subunit, b [Source:ZFIN;Acc:ZDB-GENE-040525-3]) HSP 1 Score: 1464.13 bits (3789), Expect = 0.000e+0 Identity = 850/1547 (54.95%), Postives = 1079/1547 (69.75%), Query Frame = 1
Query: 223 ALAALKDREGAKHRQLCSSL--KPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIG---VVTEILTAISFNTK-------VDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMM-EDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADEL---SDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRC-HKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKK--SRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKN-IPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXX--XXQVGKTK---FISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQII 4788
+L+ K ++ AK ++ SS +P R+LFCL NP+R +V+ KPF++ ILL+IFANCV L + P+P DSNSTN LE +E F++IFTIE LKII+YG ++HQN+Y+RN WN+LDF IVI+G VV E LT +++ D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELF+GK+HATCY N + + E+ PC L G CT L CKD W GPN+GITNFDNF AMLTVFQ +TMEGWT+V+YW+NDA G++ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ +DEE D + TS + N + E K+RC I + +R+ RR +KS F+ L++ LVFLNT+ + +EH+ QP WL QD+AN V +A+FT EM+IK+ +LGL YF FN+FD F+V I+E L ++++P+G+SV RC RLLR+FK+T++W SL +LV LL SMKSI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F Q+++TVFQILTGEDWN MY+GI ++GG + G +V +YF++LFI GNYILLNVFLAIAVDNL+ DA+ N +EE + + +K + V D + +H +H + E G + P+R +K ++ IP SAFFIFS+TN RV CH ++ H F N++LV I++SSV LAAEDPIR+ S RN IL YFDY FT +FT+EI LKM A+G LH GAFCRN FNLLDLLVV V+LVSF I ++ AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG IM+VT LL FMFA + VQLFKG+FY C+D +K + E CKG +I Y N +P V R W N+ N+DNVL M+ LF V+TFEGWP LLYK+ID+ +E+ GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK W VV S FEYV+ LI+ NTLCLA + Q + +DILN++FT VFT+E ILKL AF + YF DAWN+FD +VV+GS VDII+S+ ++ ++ G T+ ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLI MLFFIYAVIGMQ+FGKIA+ + +SI+RNNNFQTFP AVL+LFR ATGE+WQEIML+C C+ S E CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF W++YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR LKIK ++Q NEELR+VIKK+WKRTS +LLDQ++
Sbjct: 66 SLSQRKRQQYAKSKKQGSSTNSRPPRALFCLTLNNPIRRACISLVEWKPFDIFILLSIFANCVALAVYVPFPEDDSNSTNHDLETVEYAFLIIFTIETFLKIIAYGLVMHQNSYVRNGWNMLDFVIVIVGLFSVVLEFLTKEGDSSQSGGKPGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHATCYMNGSRTLADEESAPC--SLSGHGRHCTVNGTL-------CKDG-----WQGPNNGITNFDNFLFAMLTVFQCITMEGWTEVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENDEEGDQEGKRNPSMPTSETESVNTDNPNGEDDKARCCGPICRSWRRWNRFCRRKCRAAVKSTTFYWLVILLVFLNTLTISSEHYNQPDWLTEVQDVANKVLLAMFTCEMLIKMYSLGLQAYFVSLFNRFDCFVVCGGIVETILVELEIMSPLGISVFRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETVTKRSTFDNFPQALLTVFQILTGEDWNTVMYDGIMAYGGPSSSGMVVCIYFIILFICGNYILLNVFLAIAVDNLA----------DAESLNTAQKEEEEQNKRRKKQSIKQADRNSHEVHD---VAHH-------------RHGSEDDEDEPE--------------VPPGPR-----PQRLSELTIKEKTPPIPEGSAFFIFSNTNPIRVSCHRLINHQIFTNLILVFIMLSSVSLAAEDPIRSYSARNIILGYFDYAFTAIFTVEILLKMTAFGAFLHKGAFCRNYFNLLDLLVVGVSLVSFGI-------QSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSSPEECKGTYILYNIGDNALPQVRERIWFNSDFNFDNVLMAMMALFTVSTFEGWPALLYKAIDSNRENMGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNRYQYKFWYVVNSAGFEYVMFVLIILNTLCLAIQHHGQSHLFNYAMDILNMVFTGVFTVEMILKLVAFKPRGYFGDAWNVFDALVVIGSVVDIILSQVDVIESWTATAGNTEDSARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQVFGKIAMVD-GTSINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACL---PGKLCD--SESDYNPGEEKTCGSNFAIIYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEGN-----LEQANEELRAVIKKIWKRTSTKLLDQVV 1535
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Cavefish
Match: cacna1sa (calcium channel, voltage-dependent, L type, alpha 1S subunit, a [Source:ZFIN;Acc:ZDB-GENE-090514-1]) HSP 1 Score: 1335.86 bits (3456), Expect = 0.000e+0 Identity = 811/1702 (47.65%), Postives = 1088/1702 (63.92%), Query Frame = 1
Query: 208 FIADLALAALKDREGAKHRQLCS-SLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKV-----------DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN--EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVG-------KTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRW-ADYDIEAK-GRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIP-------QITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRL 5214
FI D K RE K Q + +P RSL L KNP R IV+ KPFE++IL+TIFANCV L + P P D+N+TN LE LE +F++IFT+E LKI++YG L H +AYLRN WNILDF IV +G+ T + I+ + V D+K+LRAFRVLRPLRLVSG+PSLQ+V++SI+ +M PLFHI+LLVFF+V IY+IIG+ELF K+H TCY + T+ +E+ K +G CT +CK W GPNDGIT+FDN G +MLTV+Q +T +GWT V+YW+NDA G +WPW+YFV+LILLGSFF+LN++LGVL G F+KE+EK R ++QK RE ++ ++D GY +WI +A+ + END D + + + + E+ E +R ++ R+ +RR +++KS+ F+ L+ LVF NT+V+ TEHH Q L +FQ+ +N + +F EMV+K+ ALGL YF FN+FD F+V ++EL L V++ +G+SV+RC RLLR+ K+T+YW SL +LV LL S++SI SLLLL+ LFIVIFALLGMQ+FGGK+N + RSNFD+F Q++ITVFQILTGEDWN MY+GI + GG G LVS+YF++LF+ GNYILLNVFLAIAVDNL++ + + + + + A + D D LA P+T L + FE+ ++ K + D ++E + S PR +K +P S+FFIF NKFR CH ++ + F NI+L+ IL+SS+ LAAEDPI S RN++L Y D +FT+VFT EI LKM YG LH G+FCRN+FN+LDL+VV V+L+S ++ + AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+K+IG I+LVT LL FMFA + VQLFKG+F+ C+D K+T E C+G +I+Y+ + + V R W N+ N+DN+L+GML LF V+TFEGWP LLY +ID+ E+ GPVYN ++IF++ Y+I+IAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+++ALKARP + Y P+ +Y++W +V S FEY++ LI+ NT+CL + Q + T D+LN+IFTV+FT+E LKL AF K YF D WN+FDF++V+GS VD+I+S + + ++Q G +SI FRLFRVMRLVKLL++ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIAL + + I+RNNNFQTFP AVLVLFR ATGE WQE+M C RC+ CG+ A YF+SFYM+ F+ ++ + + S+ H F+ A AK GRI+HLDVVT+L +I PPLGFG CPH AC +L+ MNMPL +DGTV FNATLFALVR L+IK Q NEELR++IKK+WKRTS +LLDQ+IPP D VTVGKFYATFLIQ FR + +R+ ++ Y P +I AG RS++ + L R S +L+ ++ R ++ ++D L + P S Q + LP + Q Q +DS+ ++ +S+ S L
Sbjct: 10 FIMDEETLKRKQREKLKKLQATGGNPRPARSLLFLTLKNPFRKACISIVEWKPFEIIILVTIFANCVALAVFMPMPEEDTNNTNSNLESLEYIFLIIFTLECFLKIVAYGLLFHADAYLRNCWNILDFVIVTMGLFTIAVDFINNISGVEAPVEQKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSILKSMLPLFHISLLVFFMVTIYAIIGLELFKCKMHKTCYYSGTDIVATVENEKASPCAEAGNGRRCTV-------NGTVCKPG-----WPGPNDGITHFDNLGFSMLTVYQCITTQGWTDVLYWVNDAIGMEWPWLYFVTLILLGSFFILNMVLGVLCGSFTKEREKSSRSGEYQKLRERQQLDEDLKGYMDWITQAEVM---END---QDRQGLLPLQEGGSDTESLYELEGLNRLMYYVRHARRWNRFFRRKCRVWVKSRLFYWLVFLLVFFNTLVIATEHHMQSQSLTNFQENSNTALLCMFAVEMVLKMYALGLPSYFMSLFNRFDCFVVSVGMLELILVHMGVMSAMGISVMRCIRLLRLIKVTKYWTSLSNLVASLLNSVRSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDQEVRRSNFDNFPQALITVFQILTGEDWNSVMYDGIMAHGGPVIPGILVSIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKEKAEEKKRKKLLRANLSDKGDE--DKSTLAKKLAEQRAKTEGIPTTAKLKVDE-----FESNVNEIKDPFPPADFPGDDEEEEPEIPT--SPRPRPMADLQLKETVVPMPEASSFFIFGPQNKFRKLCHRIINATTFTNIILLFILLSSISLAAEDPIDPMSFRNQVLAYADIVFTSVFTAEIVLKMTTYGAFLHTGSFCRNSFNILDLIVVGVSLLSMGME-------SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTMLLDFMFACIGVQLFKGKFFFCTDPLKMTEEECRGTYIHYQENALHEMEVRQREWMNSGFNFDNILNGMLALFTVSTFEGWPKLLYTAIDSNSENMGPVYNNRTEISIFFIVYLILIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSCYFEYLMFLLIMLNTMCLGMQHCNQSEHVTHLSDMLNVIFTVLFTVEMFLKLGAFKAKGYFGDPWNVFDFVIVVGSIVDVILSEIDAALAAQGGLYCLTGCANMSVSITLFRLFRVMRLVKLLNRFEGIRNLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALID-GTVINRNNNFQTFPQAVLVLFRCATGEGWQEVMQGCL---YGQRCDPKSDYLPGEEYT--CGAGFAVLYFMSFYML-------FFIYAVIGIYIF-----SVFALFHFMHFMNCMNAPCRCLAKLGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLISMNMPLNSDGTVTFNATLFALVRTALRIKTEGN-----FQQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQ--EEYYGYRPAKNKTTNEIQAGLRSIEEEA-APELQRAISGDLLNEDEMDRAMDEAAEDAIYRRDGGLFGNH-VDPFSLQR------GTPLPT-QVTSQRPLQLADSRTDEAESSPSYL 1643
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Cavefish
Match: cacna1sa (calcium channel, voltage-dependent, L type, alpha 1S subunit, a [Source:ZFIN;Acc:ZDB-GENE-090514-1]) HSP 1 Score: 1335.09 bits (3454), Expect = 0.000e+0 Identity = 807/1699 (47.50%), Postives = 1085/1699 (63.86%), Query Frame = 1
Query: 208 FIADLALAALKDREGAKHRQLCS-SLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKV-----------DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN--EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQV------GKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIP-------QITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRL 5214
FI D K RE K Q + +P RSL L KNP R IV+ KPFE++IL+TIFANCV L + P P D+N+TN LE LE +F++IFT+E LKI++YG L H +AYLRN WNILDF IV +G+ T + I+ + V D+K+LRAFRVLRPLRLVSG+PSLQ+V++SI+ +M PLFHI+LLVFF+V IY+IIG+ELF K+H TCY + T+ +E+ K +G CT +CK W GPNDGIT+FDN G +MLTV+Q +T +GWT V+YW+NDA G +WPW+YFV+LILLGSFF+LN++LGVL G F+KE+EK R ++QK RE ++ ++D GY +WI +A+ + END D + + + + E+ E +R ++ R+ +RR +++KS+ F+ L+ LVF NT+V+ TEHH Q L +FQ+ +N + +F EMV+K+ ALGL YF FN+FD F+V ++EL L V++ +G+SV+RC RLLR+ K+T+YW SL +LV LL S++SI SLLLL+ LFIVIFALLGMQ+FGGK+N + RSNFD+F Q++ITVFQILTGEDWN MY+GI + GG G LVS+YF++LF+ GNYILLNVFLAIAVDNL++ + + + + + A + D D LA P+T L + FE+ ++ K + D ++E + S PR +K +P S+FFIF NKFR CH ++ + F NI+L+ IL+SS+ LAAEDPI S RN++L Y D +FT+VFT EI LKM YG LH G+FCRN+FN+LDL+VV V+L+S ++ + AIS VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+K+IG I+LVT LL FMFA + VQLFKG+F+ C+D K+T E C+G +I+Y+ + + V R W N+ N+DN+L+GML LF V+TFEGWP LLY +ID+ E+ GPVYN ++IF++ Y+I+IAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+++ALKARP + Y P+ +Y++W +V S FEY++ LI+ NT+CL + Q + T D+LN+IFTV+FT+E LKL AF K YF D WN+FDF++V+GS VD+I+S ++S + +SI FRLFRVMRLVKLL++ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ+FGKIAL + + I+RNNNFQTFP AVLVLFR ATGE WQE+M C RC+ CG+ A YF+SFYM+ F+ ++ + + S+ H F+ + +GRI+HLDVVT+L +I PPLGFG CPH AC +L+ MNMPL +DGTV FNATLFALVR L+IK Q NEELR++IKK+WKRTS +LLDQ+IPP D VTVGKFYATFLIQ FR + +R+ ++ Y P +I AG RS++ + L R S +L+ ++ R ++ ++D L + P S Q + LP + Q Q +DS+ ++ +S+ S L
Sbjct: 12 FIMDEETLKRKQREKLKKLQATGGNPRPARSLLFLTLKNPFRKACISIVEWKPFEIIILVTIFANCVALAVFMPMPEEDTNNTNSNLESLEYIFLIIFTLECFLKIVAYGLLFHADAYLRNCWNILDFVIVTMGLFTIAVDFINNISGVEAPVEQKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSILKSMLPLFHISLLVFFMVTIYAIIGLELFKCKMHKTCYYSGTDIVATVENEKASPCAEAGNGRRCTV-------NGTVCKPG-----WPGPNDGITHFDNLGFSMLTVYQCITTQGWTDVLYWVNDAIGMEWPWLYFVTLILLGSFFILNMVLGVLCGSFTKEREKSSRSGEYQKLRERQQLDEDLKGYMDWITQAEVM---END---QDRQGLLPLQEGGSDTESLYELEGLNRLMYYVRHARRWNRFFRRKCRVWVKSRLFYWLVFLLVFFNTLVIATEHHMQSQSLTNFQENSNTALLCMFAVEMVLKMYALGLPSYFMSLFNRFDCFVVSVGMLELILVHMGVMSAMGISVMRCIRLLRLIKVTKYWTSLSNLVASLLNSVRSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDQEVRRSNFDNFPQALITVFQILTGEDWNSVMYDGIMAHGGPVIPGILVSIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKEKAEEKKRKKLLRANLSDKGDE--DKSTLAKKLAEQRAKTEGIPTTAKLKVDE-----FESNVNEIKDPFPPADFPGDDEEEEPEIPT--SPRPRPMADLQLKETVVPMPEASSFFIFGPQNKFRKLCHRIINATTFTNIILLFILLSSISLAAEDPIDPMSFRNQVLAYADIVFTSVFTAEIVLKMTTYGAFLHTGSFCRNSFNILDLIVVGVSLLSMGME-------SSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVLVTMLLDFMFACIGVQLFKGKFFFCTDPLKMTEEECRGTYIHYQENALHEMEVRQREWMNSGFNFDNILNGMLALFTVSTFEGWPKLLYTAIDSNSENMGPVYNNRTEISIFFIVYLILIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSCYFEYLMFLLIMLNTMCLGMQHCNQSEHVTHLSDMLNVIFTVLFTVEMFLKLGAFKAKGYFGDPWNVFDFVIVVGSIVDVILSEIDVSIEVNPMQAIADSENMSVSITLFRLFRVMRLVKLLNRFEGIRNLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALID-GTVINRNNNFQTFPQAVLVLFRCATGEGWQEVMQGCL---YGQRCDPKSDYLPGEEYT--CGAGFAVLYFMSFYML-------FFIYAVIGIYIF-----SVFALFHFMHFMN---CMNAPCRGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLISMNMPLNSDGTVTFNATLFALVRTALRIKTEGN-----FQQANEELRAIIKKIWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQEHFRKFMKRQ--EEYYGYRPAKNKTTNEIQAGLRSIEEEA-APELQRAISGDLLNEDEMDRAMDEAAEDAIYRRDGGLFGNH-VDPFSLQR------GTPLPT-QVTSQRPLQLADSRTDEAESSPSYL 1639
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Cavefish
Match: cacna1sb (calcium channel, voltage-dependent, L type, alpha 1S subunit, b [Source:ZFIN;Acc:ZDB-GENE-051227-1]) HSP 1 Score: 1303.5 bits (3372), Expect = 0.000e+0 Identity = 802/1711 (46.87%), Postives = 1061/1711 (62.01%), Query Frame = 1
Query: 238 KDREGAKHRQLCS-SLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVT---EILTAISFNTK-----VDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMM----EDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADEL-SDEENDG-----NSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKS---------EEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINY-KSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVG----------KTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSC-TGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIP------QITAGDRSMQGQPLILGLPRRTSSELIG-DEF-KARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLKPDS 5226
K RE K Q + +P RSLF KNP R +IV+ KPFE++ILLTIFANCV L + P P D+N TN LE LE +F+VIFT+E LKII+YG L H+ AYLRN WNILDF IV +G+ T + + AI+ D+K+LRAFRVLRPLRLVSG+PSLQ+V+NSI+ AM PLF + LLVFFLV +++I+G+EL+ K+H TCY T+ + E P PC +G CT G C+ W GPN GIT+FDNFG AMLTVFQ +TME WT V+YW+NDA G +W WIYFV++ILLGSFFVLNL+LGVLSGEFSKE+EK + ++QK RE ++ ++D GY EWI A+ L +D+E G +SD EI +++ N A +A+ R +++ + +++KS+ F+ L++ +VFLNT+V+ EHH Q FQD+AN + + F FEM K+ A GL YF FN+FD F+V I+E+ L V+ P+G+SV+RC RLLR K+T+ N K F + + L+ + Q++TGE+W+ MYNGI + GG G LVS+YF++L++VGN+ILLNVFLAIAVDNL++ + + + + + EEE A++V ++ H + TT + FE+ + K + D ++E + S PR +K +P S+FFIF NKFR CH + + F N +L+ IL+SS+ LAAED I S RNKIL Y D +FTTVFTIEI LKM YG +LH G+FCRN FN+LDL+VV V+L+S ++ + AIS +KILRVLRVLRPLRA+NRAKGLKHVVQCV VA+++IG I+LVT LL FMFA + VQL+KG+FYSC+D KLT E C+G F+ + ++ + + R W N+ N+DNV + ML LF V+TFEGWP LLYK+ID+ ED GPV+N ++F+V Y+IIIAFFM+NIFVGFVIVTF+++GE E+KNCEL KNQR+C+++ALKARP + Y P+ +Y++W +V S FEY++ LI+ NT L + Q T D LN+IFTV+FT E I+KL AF K YF D WN+FDF++V+GS VD+++S+ + + S G + +SI FFRLFRV+RL+KLL++ + IR LLWTFIKSFQA P+VALLIVMLFFIYAVIGMQ+FGKIAL + + I+RN NFQTFP A+L+L+R+ TGE WQ++ML+C +G R + CG+ A YF+SF MIC FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EA GRI+HLDVVT+L +I PPLGFG CPH AC +L+ MNMPL +DGTV FNATLFALVR +L IK +Q NEELR +IK +WKRTS +LLDQ+IPP D VTVGKFYATFLIQ FR + +R+ ++ Y P +I AG R+++ + L R S +LI DE +A + G + T F P S++ S Q+S N +QF S+S+P D +S PDS
Sbjct: 22 KQREKLKKLQATGGNPRPARSLFFFTLKNPFRKACTKIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNYTNTTLESLEYIFLVIFTLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLAVDTINAIAGTPTEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMNSILKAMIPLFQVVLLVFFLVTLFAIMGLELYKCKMHKTCYYEGTDIIALRENEVPSPC--AQAGNGRRCT-----INGTE--CRGG-----WPGPNFGITHFDNFGFAMLTVFQCITMESWTNVLYWVNDAVGNEWAWIYFVTMILLGSFFVLNLVLGVLSGEFSKEREKCRSRGEYQKLRERQQMDEDLKGYMEWITHAEVLDADQEGQGLLPLKDSDSESEILFAIE-GLNRIAYYYRLAR-RWNRVFRL----------KCAVWVKSRMFYWLVILVVFLNTLVIACEHHPQSESATRFQDVANDILLTCFAFEMFAKMYAFGLRAYFMSVFNRFDFFVVTVGILEIILVAADVMTPLGISVMRCIRLLRFVKITKIVN-------------KIYFQICVYNRLYHIFI---------------------------------QVITGEEWDTIMYNGIMAHGGPQSPGILVSIYFIILYVVGNFILLNVFLAIAVDNLTEAESLSSAQKEKEEEKARKKLMRTAPPHEEEKAKLVKSK----------------------HKTEGMPTTAKLKVDEFESNVKEVKDPFPPADFPGDDEEEEP--EIPISPRPRPMADLQLKETVVPMPEASSFFIFGPENKFRKLCHRAINATPFTNFILLLILLSSISLAAEDAIDPKSFRNKILAYADIVFTTVFTIEIVLKMTVYGAILHTGSFCRNAFNILDLIVVVVSLLSMGLE-------SSAISVIKILRVLRVLRPLRALNRAKGLKHVVQCVFVAIQTIGNIILVTMLLNFMFACIGVQLYKGKFYSCTDPLKLTEEECQGTFVKHVRNSLHDKEIGQRQWVNSDFNFDNVPNAMLALFTVSTFEGWPELLYKAIDSDAEDRGPVFNNRMDTSLFFVIYLIIIAFFMMNIFVGFVIVTFREQGEQEFKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYRVWYLVTSCYFEYLMFLLIILNTCSLGLQHCNQSDHITKLADTLNVIFTVLFTFEMIVKLIAFKAKGYFGDPWNVFDFLIVIGSIVDVVLSQVDAALESSGGLYCLHGCTYEENARVSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQAFPHVALLIVMLFFIYAVIGMQVFGKIALVD-GTEINRNANFQTFPQAILILYRTVTGEGWQKLMLACMSGKLCDPRSDYAPGEEYT------CGTNFAVFYFLSFNMICGFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKKIWAEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHRSACRRLISMNMPLNSDGTVTFNATLFALVRTDLSIKTEGN-----FEQANEELRLIIKSIWKRTSMKLLDQVIPPIGEDEVTVGKFYATFLIQEHFRKFMKRQ--EEYYGYRPTKKSAAEIQAGLRTIE-EEAAPELHRAISGDLIAEDEMDRALEGGEDGIYRRTGGLFGGLNS---DPFSSEPNSPTAAQTS--NRPLQF------SESRPEDVES-----PPDS 1598 HSP 2 Score: 82.4185 bits (202), Expect = 6.252e-15 Identity = 85/351 (24.22%), Postives = 149/351 (42.45%), Query Frame = 1
Query: 3505 ELSKNQRKCIEFALKA-----RPRKR---YTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARF---DQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSF----KNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-------------GKIAL--NNTDSSISRNNN------------------------FQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
EL + QR+ ++ L+A RP + +T + R +V K FE +IL I AN + LA ++ + TL+ L IF V+FTLE LK+ A+ Y + WNI DF++V + + N + + K + R FRV+R ++L+S S++ ++ + +K+ L V LL+ L ++A++G++++ IAL N S ++ N F F A+L +F+ T ESW ++ +D G+ A+ YF++ ++ SF ++NL + V+ F
Sbjct: 18 ELKRKQREKLK-KLQATGGNPRPARSLFFFTLKNPFRKACTKIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNYTNTTLESLEYIFLVIFTLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLAVDTINAIAGTPTEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMNSILKAMIPLFQVVLLVFFLVTLFAIMGLELYKCKMHKTCYYEGTDIIALRENEVPSPCAQAGNGRRCTINGTECRGGWPGPNFGITHFDNFGFAMLTVFQCITMESWTNVL---------------------YWVNDAVGNEWAWIYFVTMILLGSFFVLNLVLGVLSGEF 346
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Cavefish
Match: cacna1sb (calcium channel, voltage-dependent, L type, alpha 1S subunit, b [Source:ZFIN;Acc:ZDB-GENE-051227-1]) HSP 1 Score: 1302.35 bits (3369), Expect = 0.000e+0 Identity = 805/1708 (47.13%), Postives = 1062/1708 (62.18%), Query Frame = 1
Query: 238 KDREGAKHRQLCS-SLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVT---EILTAISFNTK-----VDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMM----EDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADEL-SDEENDG-----NSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL------SXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINY-KSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVG----------KTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSC-TGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIP------QITAGDRSMQGQPLILGLPRRTSSELIG-DEF-KARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLKPDS 5226
K RE K Q + +P RSLF KNP R +IV+ KPFE++ILLTIFANCV L + P P D+N TN LE LE +F+VIFT+E LKII+YG L H+ AYLRN WNILDF IV +G+ T + + AI+ D+K+LRAFRVLRPLRLVSG+PSLQ+V+NSI+ AM PLF + LLVFFLV +++I+G+EL+ K+H TCY T+ + E P PC +G CT G C+ W GPN GIT+FDNFG AMLTVFQ +TME WT V+YW+NDA G +W WIYFV++ILLGSFFVLNL+LGVLSGEFSKE+EK + ++QK RE ++ ++D GY EWI A+ L +D+E G +SD EI +++ N A +A+ R +++ + +++KS+ F+ L++ +VFLNT+V+ EHH Q FQD+AN + + F FEM K+ A GL YF FN+FD F+V I+E+ L V+ P+G+SV+RC RLLR K+T+ ++ F ++ + ++ + I Q++TGE+W+ MYNGI + GG G LVS+YF++L++VGN+ILLNVFLAIAVDNL S E+EE K EEE A++V ++ H + TT + FE+ + K + D ++E + S PR +K +P S+FFIF NKFR CH + + F N +L+ IL+SS+ LAAED I S RNKIL Y D +FTTVFTIEI LKM YG +LH G+FCRN FN+LDL+VV V+L+S ++ + AIS +KILRVLRVLRPLRA+NRAKGLKHVVQCV VA+++IG I+LVT LL FMFA + VQL+KG+FYSC+D KLT E C+G F+ + ++ + + R W N+ N+DNV + ML LF V+TFEGWP LLYK+ID+ ED GPV+N ++F+V Y+IIIAFFM+NIFVGFVIVTF+++GE E+KNCEL KNQR+C+++ALKARP + Y P+ +Y++W +V S FEY++ LI+ NT L + Q T D LN+IFTV+FT E I+KL AF K YF D WN+FDF++V+GS VD+++S+ + + S G + +SI FFRLFRV+RL+KLL++ + IR LLWTFIKSFQA P+VALLIVMLFFIYAVIGMQ+FGKIAL + + I+RN NFQTFP A+L+L+R+ TGE WQ++ML+C +G R + CG+ A YF+SF MIC FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EA GRI+HLDVVT+L +I PPLGFG CPH AC +L+ MNMPL +DGTV FNATLFALVR +L IK +Q NEELR +IK +WKRTS +LLDQ+IPP D VTVGKFYATFLIQ FR + +R+ ++ Y P +I AG R+++ + L R S +LI DE +A + G + T F P S++ S Q+S N +QF S+S+P D +S PDS
Sbjct: 18 KQREKLKKLQATGGNPRPARSLFFFTLKNPFRKACTKIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNYTNTTLESLEYIFLVIFTLECFLKIIAYGLLFHEGAYLRNCWNILDFVIVFMGLFTLAVDTINAIAGTPTEKGGGFDMKALRAFRVLRPLRLVSGVPSLQVVMNSILKAMIPLFQVVLLVFFLVTLFAIMGLELYKCKMHKTCYYEGTDIIALRENEVPSPC--AQAGNGRRCT-----INGTE--CRGG-----WPGPNFGITHFDNFGFAMLTVFQCITMESWTNVLYWVNDAVGNEWAWIYFVTMILLGSFFVLNLVLGVLSGEFSKEREKCRSRGEYQKLRERQQMDEDLKGYMEWITHAEVLDADQEGQGLLPLKDSDSESEILFAIE-GLNRIAYYYRLAR-RWNRVFRL----------KCAVWVKSRMFYWLVILVVFLNTLVIACEHHPQSESATRFQDVANDILLTCFAFEMFAKMYAFGLRAYFMSVFNRFDFFVVTVGILEIILVAADVMTPLGISVMRCIRLLRFVKITK-------------------------------------LRFFFNRFCV-------YNRLYHIFI---QVITGEEWDTIMYNGIMAHGGPQSPGILVSIYFIILYVVGNFILLNVFLAIAVDNLTEAESLSSAQKEKEEEKARKKTAPPHEEEKAKLVKSK----------------------HKTEGMPTTAKLKVDEFESNVKEVKDPFPPADFPGDDEEEEP--EIPISPRPRPMADLQLKETVVPMPEASSFFIFGPENKFRKLCHRAINATPFTNFILLLILLSSISLAAEDAIDPKSFRNKILAYADIVFTTVFTIEIVLKMTVYGAILHTGSFCRNAFNILDLIVVVVSLLSMGLE-------SSAISVIKILRVLRVLRPLRALNRAKGLKHVVQCVFVAIQTIGNIILVTMLLNFMFACIGVQLYKGKFYSCTDPLKLTEEECQGTFVKHVRNSLHDKEIGQRQWVNSDFNFDNVPNAMLALFTVSTFEGWPELLYKAIDSDAEDRGPVFNNRMDTSLFFVIYLIIIAFFMMNIFVGFVIVTFREQGEQEFKNCELDKNQRQCVQYALKARPLRCYIPKNPYQYRVWYLVTSCYFEYLMFLLIILNTCSLGLQHCNQSDHITKLADTLNVIFTVLFTFEMIVKLIAFKAKGYFGDPWNVFDFLIVIGSIVDVVLSQVDAALESSGGLYCLHGCTYEENARVSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQAFPHVALLIVMLFFIYAVIGMQVFGKIALVD-GTEINRNANFQTFPQAILILYRTVTGEGWQKLMLACMSGKLCDPRSDYAPGEEYT------CGTNFAVFYFLSFNMICGFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKKIWAEYDPEATGRIKHLDVVTLLRRIQPPLGFGKFCPHRSACRRLISMNMPLNSDGTVTFNATLFALVRTDLSIKTEGN-----FEQANEELRLIIKSIWKRTSMKLLDQVIPPIGEDEVTVGKFYATFLIQEHFRKFMKRQ--EEYYGYRPTKKSAAEIQAGLRTIEEEA-APELHRAISGDLIAEDEMDRALEGGEDGIYRRTGGLFGGLNS---DPFSSEPNSPTAAQTS--NRPLQF------SESRPEDVES-----PPDS 1590
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005302.1 (pep scaffold:Pmarinus_7.0:GL483978:134:5921:-1 gene:ENSPMAG00000004828.1 transcript:ENSPMAT00000005302.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 410.223 bits (1053), Expect = 1.921e-130 Identity = 207/299 (69.23%), Postives = 240/299 (80.27%), Query Frame = 1
Query: 3913 ISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDF-CGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSD 4806
ISI FFRLFRV+RLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIA+ + S I+RNNNFQTFP AVL+LFR ATGE+WQ+IML+C RC+ P S +F CGS A YF+SFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+H+DVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR +LKIK ++Q NEELR+VIKK+WKRT+ +LLDQ++PP D
Sbjct: 17 ISITFFRLFRVLRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAMQD-GSQINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACM---PGRRCD---PDADASVGEEFSCGSSFAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHVDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTSLKIKTDGN-----LEQANEELRAVIKKIWKRTNMKLLDQVVPPAGGD 303 HSP 2 Score: 68.1662 bits (165), Expect = 3.784e-12 Identity = 46/157 (29.30%), Postives = 86/157 (54.78%), Query Frame = 1
Query: 1780 NPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSR----SNFDHFWQSVITVFQILTGEDWNEEMY----------NGIRSFGGVNGLGALVSL-YFVVLFIVGNYILLNVFLAIAVDN 2205
N I ++ R R+LR+ KL +R+L+ +KS +++ + LL+ + I+A++GMQMF GK + S+ +NF F Q+V+ +F+ TGE W + M + S G G+ ++ YFV +++ ++++N+F+A+ +DN
Sbjct: 15 NRISITFFRLFRVLRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GKIAMQDGSQINRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGRRCDPDADASVGEEFSCGSSFAIFYFVSFYMLCAFLIINLFVAVIMDN 170 HSP 3 Score: 53.1434 bits (126), Expect = 2.872e-7 Identity = 52/213 (24.41%), Postives = 87/213 (40.85%), Query Frame = 1
Query: 625 TAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQ----------------GYKWPWIYFVSLILLGSFFVLNLILGVLSGEF 1215
+A N ++ I R FRVLR ++L+S ++ +L + I + + L ++ALL+ L IY++IGM++F GK+ M+D S I ++N NF F A+L +F+ T E W +M + G + YFVS +L +F ++NL + V+ F
Sbjct: 9 SAAEDNNRISITFFRLFRVLRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF-GKIA-----------MQD------------------------GSQINRNN--------------NFQTFPQAVLLLFRCATGEAWQDIMLACMPGRRCDPDADASVGEEFSCGSSFAIFYFVSFYMLCAFLIINLFVAVIMDNF 171
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008632.1 (pep scaffold:Pmarinus_7.0:GL481395:151307:166184:-1 gene:ENSPMAG00000007818.1 transcript:ENSPMAT00000008632.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 376.326 bits (965), Expect = 3.147e-115 Identity = 257/512 (50.20%), Postives = 338/512 (66.02%), Query Frame = 1
Query: 1507 MKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--RSNFDHFWQSVITVF-QILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKD-EKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSAC-----PRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLK 3015
+KS F+ +++ LVFLNT+ + +EH+ Q WL QD AN V +ALFT EM++KI +LGL YF FN+FD F+V I+E L KV++P+G+SVLRC RLLR+FK T+YWNSL +LV LL SM+SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS+FD+F +++TVF QILTGEDWN MY+GIR++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+ DA+ + E E + + E++ NG G S C ++ + + E +EK Y + D + + PRR +K + +P SAFF+FS TN FR+ CH+++ H+ F N++LV I++SSV LAAEDPIR++S RN+IL YFDY FTT+FTIEI LKM AYG +H G+FCR+ FNLLDLLVV V+L+SF I + + AIS VKILRVLRVLRPLRAINRAKGLK
Sbjct: 57 VKSTAFYWMVIVLVFLNTLTIASEHYDQMQWLTHVQDTANKVLLALFTLEMLVKIYSLGLQAYFVSLFNRFDCFVVCGGIVETILVELKVMSPLGISVLRCVRLLRIFKATRYWNSLSNLVASLLNSMRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQVRRSSFDNFPTALLTVFQQILTGEDWNSVMYDGIRAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA----------DAESLTSAQREAEEEKERKKIARITPRERVWNGNPGLV-------SVC-VSVWKIPLDDPDGEDDKEKDPYPPSEYPGWRRHDTGDDDESEPEVPMGPRPRRLSELQIKEKVVPMPESSAFFLFSHTNPFRILCHHIINHTIFTNLILVFIMLSSVSLAAEDPIRSTSFRNEILGYFDYAFTTIFTIEIMLKMTAYGAFVHKGSFCRSYFNLLDLLVVGVSLISFGI------QWSSAISVVKILRVLRVLRPLRAINRAKGLK 544 HSP 2 Score: 82.4185 bits (202), Expect = 5.612e-16 Identity = 68/268 (25.37%), Postives = 129/268 (48.13%), Query Frame = 1
Query: 3595 KMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSA-TGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
K + V S F ++++ L+ NTL +A+ Q ++ T D N + +FTLE ++K+ + + YF +N FD VV G V+ + ++ + I+ R R++R+ K +S+ L+ + + S +++ + LL+ + I++++GMQ+FG N D + R ++F FP A+L +F+ TGE W +M F G V YFI ++ +++++N+F+A+ +DN
Sbjct: 52 KCRAAVKSTAFYWMVIVLVFLNTLTIASEHYDQMQWLTHVQDTANKVLLALFTLEMLVKIYSLGLQAYFVSLFNRFDCFVVCGGIVE--------TILVELKVMSPLGISVLRCVRLLRIFKATRYWNSLSNLVASLLNSMRSIASLLLLLFLFIIIFSLLGMQLFG--GKFNFDETQVRRSSFDNFPTALLTVFQQILTGEDWNSVMYD---------------GIRAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNL 293 HSP 3 Score: 74.7146 bits (182), Expect = 1.199e-13 Identity = 121/510 (23.73%), Postives = 207/510 (40.59%), Query Frame = 1
Query: 481 VFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQA-MTMEGWTQVMY-WINDAQGYKWP----WIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELS-------------DEENDGNSDDY--------REISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFI-------------LILSLVFLNTMVLCTEHHKQPLWLDSFQD----IANIVFVALFTFEMVIKILALGL----GEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSL 1866
V + +FT+E +KI S G AY + +N D F+V G+V IL + + + I LR R+LR + SL ++ S++ +M+ + + LL+F ++I+S++GM+LF GK + DE Q R ++FDNF A+LTVFQ +T E W VMY I G +P IYF+ L + G++ +LN+ L + + + + + ++E+E K+ + + W +S D E+D D Y R T D PE + + R ++ + + + ++ + F I LIL + L+++ L E P+ SF++ + F +FT E+++K+ A G G + FN DL +V S+I + I SV++ R+LRV + + N + L
Sbjct: 98 VLLALFTLEMLVKIYSLGL----QAYFVSLFNRFDCFVVCGGIVETILVELKVMSPLGISVLRCVRLLRIFKATRYWNSLSNLVASLLNSMRSIASLLLLLFLFIIIFSLLGMQLFGGKFN----------------------------------FDETQ---------VRR--------SSFDNFPTALLTVFQQILTGEDWNSVMYDGIRAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQREAEEEKERKKIARITPRERVWNGNPGLVSVCVSVWKIPLDDPDGEDDKEKDPYPPSEYPGWRRHDTGDDDESEPEVPMGPRPR-RLSELQIKEKVVPMPESSAFFLFSHTNPFRILCHHIINHTIFTNLILVFIMLSSVSLAAE---DPIRSTSFRNEILGYFDYAFTTIFTIEIMLKMTAYGAFVHKGSFCRSYFNLLDLLVVGVSLISFGIQWSSAI-----SVVKILRVLRVLRPLRAINRAKGL 543 HSP 4 Score: 72.0182 bits (175), Expect = 8.138e-13 Identity = 48/148 (32.43%), Postives = 79/148 (53.38%), Query Frame = 1
Query: 286 PDRSLFCL-EKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVD-IKSLRAFRVLRPLRLVSGLPSLQ 723
P+ S F L NP RI I++ F LIL+ I + V L P + ++ N IL + F IFTIE LK+ +YG +H+ ++ R+ +N+LD +V + +++ I +++ + +K LR RVLRPLR ++ L+
Sbjct: 402 PESSAFFLFSHTNPFRILCHHIINHTIFTNLILVFIMLSSVSLAAEDPIRS--TSFRNEILGYFDYAFTTIFTIEIMLKMTAYGAFVHKGSFCRSYFNLLDLLVVGVSLIS---FGIQWSSAISVVKILRVLRVLRPLRAINRAKGLK 544
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008630.1 (pep scaffold:Pmarinus_7.0:GL481395:151307:166184:-1 gene:ENSPMAG00000007818.1 transcript:ENSPMAT00000008630.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 376.326 bits (965), Expect = 6.286e-115 Identity = 257/512 (50.20%), Postives = 338/512 (66.02%), Query Frame = 1
Query: 1507 MKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--RSNFDHFWQSVITVF-QILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKD-EKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSAC-----PRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLK 3015
+KS F+ +++ LVFLNT+ + +EH+ Q WL QD AN V +ALFT EM++KI +LGL YF FN+FD F+V I+E L KV++P+G+SVLRC RLLR+FK T+YWNSL +LV LL SM+SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS+FD+F +++TVF QILTGEDWN MY+GIR++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+ DA+ + E E + + E++ NG G S C ++ + + E +EK Y + D + + PRR +K + +P SAFF+FS TN FR+ CH+++ H+ F N++LV I++SSV LAAEDPIR++S RN+IL YFDY FTT+FTIEI LKM AYG +H G+FCR+ FNLLDLLVV V+L+SF I + + AIS VKILRVLRVLRPLRAINRAKGLK
Sbjct: 77 VKSTAFYWMVIVLVFLNTLTIASEHYDQMQWLTHVQDTANKVLLALFTLEMLVKIYSLGLQAYFVSLFNRFDCFVVCGGIVETILVELKVMSPLGISVLRCVRLLRIFKATRYWNSLSNLVASLLNSMRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQVRRSSFDNFPTALLTVFQQILTGEDWNSVMYDGIRAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLA----------DAESLTSAQREAEEEKERKKIARITPRERVWNGNPGLV-------SVC-VSVWKIPLDDPDGEDDKEKDPYPPSEYPGWRRHDTGDDDESEPEVPMGPRPRRLSELQIKEKVVPMPESSAFFLFSHTNPFRILCHHIINHTIFTNLILVFIMLSSVSLAAEDPIRSTSFRNEILGYFDYAFTTIFTIEIMLKMTAYGAFVHKGSFCRSYFNLLDLLVVGVSLISFGI------QWSSAISVVKILRVLRVLRPLRAINRAKGLK 564 HSP 2 Score: 82.4185 bits (202), Expect = 4.892e-16 Identity = 68/268 (25.37%), Postives = 129/268 (48.13%), Query Frame = 1
Query: 3595 KMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSA-TGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
K + V S F ++++ L+ NTL +A+ Q ++ T D N + +FTLE ++K+ + + YF +N FD VV G V+ + ++ + I+ R R++R+ K +S+ L+ + + S +++ + LL+ + I++++GMQ+FG N D + R ++F FP A+L +F+ TGE W +M F G V YFI ++ +++++N+F+A+ +DN
Sbjct: 72 KCRAAVKSTAFYWMVIVLVFLNTLTIASEHYDQMQWLTHVQDTANKVLLALFTLEMLVKIYSLGLQAYFVSLFNRFDCFVVCGGIVE--------TILVELKVMSPLGISVLRCVRLLRIFKATRYWNSLSNLVASLLNSMRSIASLLLLLFLFIIIFSLLGMQLFG--GKFNFDETQVRRSSFDNFPTALLTVFQQILTGEDWNSVMYD---------------GIRAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDNL 313 HSP 3 Score: 75.0998 bits (183), Expect = 9.146e-14 Identity = 121/510 (23.73%), Postives = 207/510 (40.59%), Query Frame = 1
Query: 481 VFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQA-MTMEGWTQVMY-WINDAQGYKWP----WIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELS-------------DEENDGNSDDY--------REISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFI-------------LILSLVFLNTMVLCTEHHKQPLWLDSFQD----IANIVFVALFTFEMVIKILALGL----GEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSL 1866
V + +FT+E +KI S G AY + +N D F+V G+V IL + + + I LR R+LR + SL ++ S++ +M+ + + LL+F ++I+S++GM+LF GK + DE Q R ++FDNF A+LTVFQ +T E W VMY I G +P IYF+ L + G++ +LN+ L + + + + + ++E+E K+ + + W +S D E+D D Y R T D PE + + R ++ + + + ++ + F I LIL + L+++ L E P+ SF++ + F +FT E+++K+ A G G + FN DL +V S+I + I SV++ R+LRV + + N + L
Sbjct: 118 VLLALFTLEMLVKIYSLGL----QAYFVSLFNRFDCFVVCGGIVETILVELKVMSPLGISVLRCVRLLRIFKATRYWNSLSNLVASLLNSMRSIASLLLLLFLFIIIFSLLGMQLFGGKFN----------------------------------FDETQ---------VRR--------SSFDNFPTALLTVFQQILTGEDWNSVMYDGIRAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQREAEEEKERKKIARITPRERVWNGNPGLVSVCVSVWKIPLDDPDGEDDKEKDPYPPSEYPGWRRHDTGDDDESEPEVPMGPRPR-RLSELQIKEKVVPMPESSAFFLFSHTNPFRILCHHIINHTIFTNLILVFIMLSSVSLAAE---DPIRSTSFRNEILGYFDYAFTTIFTIEIMLKMTAYGAFVHKGSFCRSYFNLLDLLVVGVSLISFGIQWSSAI-----SVVKILRVLRVLRPLRAINRAKGL 563 HSP 4 Score: 72.0182 bits (175), Expect = 9.586e-13 Identity = 47/142 (33.10%), Postives = 77/142 (54.23%), Query Frame = 1
Query: 286 PDRSLFCL-EKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVD-IKSLRAFRVLRPLRLVS 705
P+ S F L NP RI I++ F LIL+ I + V L P + ++ N IL + F IFTIE LK+ +YG +H+ ++ R+ +N+LD +V + +++ I +++ + +K LR RVLRPLR ++
Sbjct: 422 PESSAFFLFSHTNPFRILCHHIINHTIFTNLILVFIMLSSVSLAAEDPIRS--TSFRNEILGYFDYAFTTIFTIEIMLKMTAYGAFVHKGSFCRSYFNLLDLLVVGVSLIS---FGIQWSSAISVVKILRVLRVLRPLRAIN 558
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010500.1 (pep scaffold:Pmarinus_7.0:GL477503:21958:35427:1 gene:ENSPMAG00000009511.1 transcript:ENSPMAT00000010500.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 271.166 bits (692), Expect = 1.442e-82 Identity = 143/271 (52.77%), Postives = 179/271 (66.05%), Query Frame = 1
Query: 4012 SFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIP-AEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVG 4821
S QALPYV LLI MLFFIYA++GMQ+FG + L++ + I+ +NNFQTF A+++LFRSATGE+WQEIMLSC K CE + + CGS AY YF+SF +CSFL++NLFVAVIMDNF+YLTRD SILGPHHLDEF+ W DYD A GRI + + +L +SPPLG G CP A +LVRM+MP+ D TV F TL AL+R L IKI A DK D ELR + +W S + LD ++PP + +TVG
Sbjct: 1 SLQALPYVCLLIAMLFFIYAIVGMQVFGNVKLDD-EGGITEHNNFQTFFQALMLLFRSATGEAWQEIMLSCL---SKKPCE-----QHSLNGENVCGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRIWGDYDPAATGRITYTKMYELLRHMSPPLGLGKKCPVRIAYKRLVRMDMPIAEDNTVHFTTTLMALIRTALDIKIAKAGADKFECDS---ELRKEMMAIWPTLSQKTLDILVPPHRAVDLTVG 259 HSP 2 Score: 58.5362 bits (140), Expect = 3.712e-9 Identity = 36/119 (30.25%), Postives = 67/119 (56.30%), Query Frame = 1
Query: 1885 SMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS----RSNFDHFWQSVITVFQILTGEDWNEEMYNGI-------RSFGGVNGLGA-LVSLYFVVLFIVGNYILLNVFLAIAVDN 2205
S++++ + LL+ + I+A++GMQ+FG LD + +NF F+Q+++ +F+ TGE W E M + + S G N G+ YFV + ++++LN+F+A+ +DN
Sbjct: 1 SLQALPYVCLLIAMLFFIYAIVGMQVFG-NVKLDDEGGITEHNNFQTFFQALMLLFRSATGEAWQEIMLSCLSKKPCEQHSLNGENVCGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDN 118
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003634.1 (pep scaffold:Pmarinus_7.0:GL483626:1829:10505:1 gene:ENSPMAG00000003326.1 transcript:ENSPMAT00000003634.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 246.899 bits (629), Expect = 4.467e-75 Identity = 130/178 (73.03%), Postives = 145/178 (81.46%), Query Frame = 1
Query: 3913 ISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDF-CGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLD 4443
ISI FFRLFRVMRLVKLLSK + IR LLWTFIKSFQALPYVALLIVM+FFIYAVIGMQ+FGKIA+ + I+RNNNFQTFP AVL+LFR ATGE+WQEI+L C RC+ P + + +F CGS A YFISFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLD
Sbjct: 28 ISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMMFFIYAVIGMQIFGKIAMQD-GMQINRNNNFQTFPQAVLLLFRCATGEAWQEILLGCM---SGRRCD---PESDYNVGEEFTCGSNFAIIYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLD 198 HSP 2 Score: 62.003 bits (149), Expect = 1.083e-10 Identity = 42/159 (26.42%), Postives = 82/159 (51.57%), Query Frame = 1
Query: 1786 IGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGG---KYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEM--------------YNGIRSFG-GVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNL 2208
I ++ R R++R+ KL +R+L+ +KS +++ + LL+ + I+A++GMQ+FG + + +NF F Q+V+ +F+ TGE W E + YN F G N +YF+ +++ ++++N+F+A+ +DN
Sbjct: 28 ISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVMMFFIYAVIGMQIFGKIAMQDGMQINRNNNFQTFPQAVLLLFRCATGEAWQEILLGCMSGRRCDPESDYNVGEEFTCGSN----FAIIYFISFYMLCAFLIINLFVAVIMDNF 182
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Yeast
Match: CCH1 (Voltage-gated high-affinity calcium channel; involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and partially co-localizes with Mid1p; however, evidence suggests CCH1 is not required for Mid1p function [Source:SGD;Acc:S000003449]) HSP 1 Score: 119.013 bits (297), Expect = 5.075e-27 Identity = 152/697 (21.81%), Postives = 293/697 (42.04%), Query Frame = 1
Query: 2581 AFFIFSDTNKFRVFCHNVVC----------------------HSYFGNI-----VLVCILVSSVMLAAE---DPIRTSSRRNKILNY---FDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRK--RYTPQGHLRYKMWSVVCSKK-FEYV-ILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWV-AYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDW---SILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGF 4548
+++ FS ++FR FC +V SYF +I V + L + +++ P+ + N+ D F F+IE +K +A GF+ P A+ RN +N +D V+ S I+++ K N +S + I+ + K I + L++ L+F F V + +FKGR +C+D S L C ++ N +I S R ++ L+ D+ S +L+ + + EGW LL +++ + G A+F V + + F++N+FV F++ + S Y E K + + +A+P+ +R + + KK F Y L ++L + + P + + T VF ++ L + + YF WN +++ +++ + + V + + N F ++ + ++ + D++ +LL T + S + + +LF +YA+ Q+FG L S+ + N NF+T +++VLFR + GE W IM T ++ + ++S + CGS AY +S+ +I ++ +N+FV++I+ NF Y+ R S + + ++I W+ +D + G + + ++ PL F
Sbjct: 1155 SYYFFSPQHRFRRFCQRLVPPSTGKRTDGSRFFEDSTDLYNKRSYFHHIERDVFVFIFALATILLIVCSCYVTPLYRMHHKMGTWNWSSALDCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCVLI----SMWINLIAYLKNNGNLSRIFKGLTALRALRCLTISNTARQTFNLVMFDGLNK-IFEAGLISLSLLFPFTVWGLSIFKGRLGTCNDGS-LGRADCYNEYSNSVFQWDIMS--PRVYQQPYLHLDSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPATVMGSAGNALFLVLFNFLSMVFILNLFVSFIVNNQARTTGSAYFTIE-EKAWLESQKLLSQAKPKAIPNLIELSRVRQFFYQLAVEKKNFYYASFLQVVLYLHIIMLLSRSYNPGNLIGYQGVYFMFSTSVFLIQEALHMCGEGPRLYFRQKWNSIRLSIIIIAFI-------MNAVAFHVPASHYWFHNIKGFFLLVIFLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVYAIALNQIFG---LTRLGSNTTDNINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSEPYCSSD-------DNSTYTDCGSETYAYLLLMSWNIISMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSYLPRIMHSFDGPLSF 1825 HSP 2 Score: 69.707 bits (169), Expect = 4.840e-12 Identity = 61/272 (22.43%), Postives = 124/272 (45.59%), Query Frame = 1
Query: 553 AYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLV---SGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCY----NNVTNEMMEDPKPC-----MVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIE-KADE 1329
A+ R++WN +D + + L+ S++TK I+ + +LR LRLV +G+PS +L + + L +++ ++ + + + I+G+++F G C + T+ D + C V Y S + ++C + P +G +FDN +M VF M+ +T +MY+ D+ ++F+ I + + ++LNL++ VL F E+ +K+ R+ + GY ++ + KA++
Sbjct: 488 AFARSSWNRIDLVSSVSFWLGMFLSIKSYDTKTGIRIFKPLAILRILRLVNVDTGMPS---ILRGLKYGIPQLVNVSSMLVYFWIFFGILGVQIFQGSFRRQCVWFNPEDPTDTYQYDMQFCGGYLDPVTKRKQNYIYEDGSEGSVSKGFLCPQYSKCVSNANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMDSDEMA-ACLFFIVCIFVLTIWLLNLLIAVLVSSFEIANEEYKKKKFIYGSRKTGYVARIVTGYWKYFKLKANQ 755 HSP 3 Score: 65.855 bits (159), Expect = 8.444e-11 Identity = 76/344 (22.09%), Postives = 145/344 (42.15%), Query Frame = 1
Query: 238 KDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNR-PYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVD--IKSLRAFRVLRPLRLV-SGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKL---------HATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWP---------WIYFVSLILLGSFFVLNLILGVL 1203
K +G++ + + L RS F +++ V +FI F + +L I +C V + R + G N ++ L+ F+ F+IE +K ++ GF+ NAYLRN WN +D F V+I + ++ + N + K L A R LR L + + + +V+ + +F L+ L+ +++ G+ +F G+L A CYN +N + + +SP Q ++ + D+F A +++Q +++EGW ++ + ++ G P ++ V L F+LNL + +
Sbjct: 1179 KRTDGSRFFEDSTDLYNKRSYFHHIERD-VFVFI--------FALATILLIVCSCYVTPLYRMHHKMGTWNWSS----ALDCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFID-FCVLISMWINLIAYLKNNGNLSRIFKGLTALRALRCLTISNTARQTFNLVM---FDGLNKIFEAGLISLSLLFPFTVWGLSIFKGRLGTCNDGSLGRADCYNEYSNSV---------------FQWDIMSPRVYQQPYL------------------HLDSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPATVMGSAGNALFLVLFNFLSMVFILNLFVSFI 1472
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Nematostella
Match: EDO46991 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNU9]) HSP 1 Score: 1461.43 bits (3782), Expect = 0.000e+0 Identity = 871/1761 (49.46%), Postives = 1146/1761 (65.08%), Query Frame = 1
Query: 256 KHRQLCSSLKPDRSLFCLEKKNPVR-----IFIARIVD--SKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNE-MMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADEL-----SDEENDGNSD---DYREISTSLD-----HNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVN-GLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKD--EKLANGGVGDACSITNHPST------CGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKT-------ESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQII-PPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQ----KDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPN-GGIQFQNLAQKSDSKPNDNKSTGSRLKPDSPTFTDDKSEIFDYFIRVPTADS-LYHNSRPSQVSTN---------SISLYDGRRIGQR 5370
+ ++ ++++P R+LFCL NP+R +F +D PF+V+IL+TIFANC L +P P DS+ N LE E VF+ IFT+E+ LKII+YGF++H AYLRN WNILDF IV++G+ T I+ + D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII A+ PLFHIALLV F+V+IY+IIG+ELFMGKLH+TCY+NVT + ++P PC +GYSC+ P GQ +C ++W GPN GITNFDN GLA LTVFQ +T+EGWT VMY INDA G WPW+YFV+LI+ GSFFVLNL+LGVLSGEF+KEK + + +FQK RE + + Y GY +WI +A+++ + E+ +G +D +R + D NQ AA ++ R KILKRF R R + K++ F+ ++ VFLN++ L EH+ QP +L F D AN +F+ALFT EMV+K+ LG YF+ FN+FD +V+ S++EL LT PIG+S+LRC RLLR+FK+T+YW+SL +LV LL SM+SI LLLL+ LF+VIF+LLGMQ+FGGK+NL + RSNFD FW++++TVFQILTGEDWN MY GI+S+GG+ L A+ LYF+ L +VGNYILLNVFLAIAVDNL+D + E + K + + E M + + KD K A+ G + + T G +RKH + DS D +++++ + + +PP S+ FIFS+TN FRV CH + +SYF N +L+ I+VSS MLAAEDP+ ++S+RN++LNYFDY FT VFTIEIT+K+IAYG +LH G+FCR+ FNLLD LVV + +I + + IS V+ILRVLRVLRPLRAINRAKGLKHVVQCV VAVK+IG IMLVT L F+FAV+ VQLFKG F+SC+D+ K+T C+GQ+I +K P V++R W+ N+++V MLTLF V TFEGWPG+L S+D+ D GP N VAI+YV YIIIIAFFMINIFVGFVIVTFQ EGE E+K+CEL KNQRKC+EFALKARP +RY P L++ +W VV S+ FEY+I + I NT+ L ++ +PK YT LD NI FT VF LE ILKL AF KNYF D WN+FDF+VV+GS VD + ++V + + FFRLFR +RLVKLL++ I+ LLWTFIKSFQALPYV LLI+M FFIYAV+GMQMFG+IA+ + ++ I+RNNNFQTFP +++VLFRSATGE+WQ IML+CT T ++C+ P+ CG+ AY YF SFY ICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF+ W++YD EA G ++H+D+VT+L +I+PPLGFG CPH AC +LV MNMPL DGTV FNATLF LVR +L IK P + K +++ NEE+R++I KVW +TS + LD+II PP D VTVGKFYAT+LIQ +FR ++ R+ + +D + AG R++ G L RR S + D+ + +K K F S K +TP S P SSL G I+ +K +S P + + P + TF+ D + VP S + N + S+ S + ++ L + R +G R
Sbjct: 33 RQKKPTNAVRPKRALFCLTLGNPIRSTAISLFTVFFLDVFRTPFDVMILITIFANCAALAAFQPLPEQDSSLINEELEVAEFVFLGIFTMESVLKIIAYGFVMHPGAYLRNGWNILDFVIVVVGLAT-IIVKLYTPDSFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKALIPLFHIALLVVFVVIIYAIIGVELFMGKLHSTCYDNVTGQPTFDEPHPC--STESEGYSCSNAGP---GQ--VC-----LKKWEGPNYGITNFDNIGLACLTVFQCITLEGWTDVMYSINDAIGNSWPWLYFVTLIIWGSFFVLNLVLGVLSGEFAKEKARAQKSGEFQKLREKQLVDDAYHGYLDWISQAEDIEGDSSAGEDEEGKADRKPSFRRRKENDDISKNKENQEDSAASDQGWIDRKKKILKRFHHRLRRSCRKAV---KTQWFYWTVIVFVFLNSLTLALEHYNQPEFLTQFLDKANKLFLALFTLEMVVKMYCLGFHGYFASLFNRFDCLVVISSLLELGLTEAMDQRPIGISMLRCVRLLRIFKVTRYWSSLSNLVASLLNSMRSIMGLLLLLSLFMVIFSLLGMQIFGGKFNLGDEDVPRSNFDSFWRALVTVFQILTGEDWNAVMYTGIQSWGGITESLSAIPILYFIFLVVVGNYILLNVFLAIAVDNLADAESLTEMEEEKKKEREEELEMKLRMEEKESSSNKDLENKRASTSSGKSHRLIKIWKTNELLHLAGKIRVSRLRKHPITDAESPSLAE-------------------DSKATLNRDHESVRSATSTEVMDHEPMPPESSLFIFSNTNCFRVVCHRIATNSYFVNFILLLIIVSSCMLAAEDPLNSNSKRNQVLNYFDYFFTAVFTIEITIKIIAYGVILHKGSFCRSAFNLLDFLVV-----AVSIVSIALRDSSSQISVVRILRVLRVLRPLRAINRAKGLKHVVQCVFVAVKTIGNIMLVTVLFNFLFAVIGVQLFKGTFFSCTDAEKITKRECQGQYIEFKGPGLTNPVVKDREWQPQTFNFNDVPQAMLTLFTVMTFEGWPGILESSMDSTDVDEGPFLNNRPWVAIYYVIYIIIIAFFMINIFVGFVIVTFQNEGEEEFKDCELDKNQRKCVEFALKARPTRRYIPTNRLQFHVWRVVTSQPFEYLIFAFITGNTILLMMQYYNEPKLYTRVLDGFNIGFTSVFLLECILKLFAFKPKNYFLDRWNLFDFVVVVGSVVD--------ITMNEVSSEQMFAFGFFRLFRALRLVKLLNQGSGIKTLLWTFIKSFQALPYVGLLIIMTFFIYAVVGMQMFGRIAI-DPETQINRNNNFQTFPQSLMVLFRSATGENWQLIMLACTDT-PNAKCD---PNAYPQDTDGLCGTDFAYAYFCSFYAICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRVWSEYDPEASGCVKHVDIVTVLKRIAPPLGFGKFCPHREACKRLVSMNMPLNRDGTVNFNATLFGLVRTSLSIKRP--EGKGSLEKANEEMRAIIMKVWPKTSQEFLDEIIQPPGGDDEVTVGKFYATYLIQEYFRRFKARQRAENAQYQDAHSTQALQAGLRTLHGLGPQL---RRAISGHLDDDDEELFLKEDIQQKSQHKRFWESLKNAVTPSPRH--SRP---SSLRRPGSIRLSAFIKKGNSTPEAQRKSS---LPATLTFSHGPLLTSDRQLLVPPQQSDVNANDKESKQSAHVPSKPPLKGTVYLTEKRYLGAR 1727
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Nematostella
Match: EDO46797 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RP56]) HSP 1 Score: 253.447 bits (646), Expect = 7.894e-68 Identity = 203/750 (27.07%), Postives = 339/750 (45.20%), Query Frame = 1
Query: 295 SLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSL---RAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKL---------HATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPN--DGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRK-EQFQKEREAKRQNQ---------------------------DYLGYKEWIEKA--------------DELSDEENDGNSDDYREISTSLDHNQNPEAAIEE-------------MAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK-----KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAV-------DNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQ 2301
SL CL +P+R+F ++ FE+++ L I NC++LG+N P E+ E +F I+T+E KIIS GF+ AYLR+ WN LD +V + ++ DI SL R RVLR R +S L L+ ++NS++ ++K L + +L F + + ++IG++LF G+L +AT NN ++ + +P + G C ++ C + VGPN G TNFD+ G +++ FQ +TM+ W + + + G +W +YFV I SF++LNL+L V+ + E D + Q Q Q+Q L + W+ ++ ++ +D + + H P+ EE + + + +L +R +++ +++ F +I L+ LNT+VL +H P L DI N +F LF EM++KI A GL +Y +N FD I++ S + L G+S+ R RLLRV L Q W ++ L+ + S+ IF++ ++G+ I +FA++GM++FG Y + R NF F S + VF+IL E W E +++ +R V AL L+F+ IVGN+I+LN+F+A+ + ++L + E+ VN C + + M Q
Sbjct: 40 SLLCLGPVHPLRMFCILLITHPYFEIIVTLVILVNCIILGLNDPP------------EEAEYIFTAIYTLEMICKIISRGFVKDSYAYLRDTWNWLDSLVVFLSYLS---------LAPDIASLSGIRTLRVLRAFRTISALKGLRAMVNSLLRSLKLLTDVLVLFLFSLCVLALIGLQLFTGELRNKCVLETANATTINNPSSWYHREGEPLLCGFSSTAGRCPA--------NYTCVAH------VGPNPDHGFTNFDDIGWSLVMAFQILTMDFWENLYDRVLRSMG-EWYMMYFVVGIFSCSFYLLNLVLAVVYMSYHHEMNLTDNEVTQSQVTHSPVTQSQVTHSPVTQSWVTHSPVTQSRVSQSRVTQSLVTQSWLMQSLVTQSPVTESRVSQSRVTQSRAHPKTDTIQVLEPLESHLYPPDEEEEETKPLTPPSLNGIVLGEDQEKGVLCPKYPRLSRACSALVEFIQRPLFDGIIAGLILLNTVVLTMYYHGMPDDLTFVLDILNAIFTGLFILEMIVKIFAFGLVKYICNKWNLFDSVIIITSAVAYFLG-----TSTGVSIFRILRLLRVLYLAQSWETMAKLIRAIAHSVDPIFNITCILGVIIYVFAVVGMRVFGPHYTAEAFGSRGIPRWNFTDFTHSFMMVFRILCSE-WVEPLWDCMR----VTNTAAL--LFFLPALIVGNFIVLNLFVALLLNSFAKKEEDLHREASEQPYVNPCSCLAHLTRTRKTRMYYTQ 741 HSP 2 Score: 223.016 bits (567), Expect = 2.111e-58 Identity = 181/620 (29.19%), Postives = 315/620 (50.81%), Query Frame = 1
Query: 2608 KFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAED-PIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAF--CRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSV-ENRT---------WENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTF----QKEGESEYKNCELSKNQRKCIEFALKARPRK----RYTPQGHLRYKMWSVVCSKKFEYVILSLILANT-LCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLII-NLFVAVIMDNFD 4398
KFR V H YF +L ++VSS L ED + + LN+ +++F +F++E LK+I +GF+ + + C + + + V + + + ++++ + ++ AI+R G+K V+ + A+ IG +++V+ L MF++ VQLF G+FY C +N + K PSV N+T W N +N+DNV++G L L VAT+EGW ++ ++D+ K D P Y N ++V +II+ +FF++N+FVG +I F +K E L+++QRK ++ + A RK R P R K++ +V S +FE IL++I+ N + + +DQ P T I N + +F LE I+K+ A +YF AW+IFDF+VV+ S V + + + S+ G + + R+FRV RL++++ IR+LL I S AL + L+ ++ FIYA+IGM FG I +++ NF+TF ++++++FR TG W +I+ + + C+ + CG + +++ Y++ FLII N+++AV++DN +
Sbjct: 781 KFRCRVRCFVEHRYFEWFILFTVMVSSFTLVFEDIHLHQKPDLERALNFLNFLFAAIFSLEFILKVIGFGFVSYFTSVWNCLDALIVSVCVSVACLFENPNLSVFRSFRTVRGLRPLR------------AISRLGGMKVVINALFAAIPGIGSVLVVSMLFWLMFSISGVQLFAGKFYKC---------------VNAEDEKLSPSVIPNKTACLDHPDYRWVNANVNFDNVINGFLALLQVATYEGWMEVMADAVDSTKIDQQPSYEANLIAYAYFVVFIIVGSFFVLNLFVGVIIDNFNTLKKKYEEINSMGMLLTESQRKWVQILMAAAKRKPPSNRLRPTDCFRGKLFDLVSSNQFEVFILTVIMCNMGMMMVQHYDQPPL----TTVIGNYVLVGIFLLEAIIKIIAMRL-HYFKKAWSIFDFVVVVSSIVGMYLGMSTESAVVSPGLLRVL-----RVFRVARLLRVVQFAKRIRQLLVAIIISMPALFNIGTLLFLVMFIYAIIGMSSFGNI---KKQGALNDLVNFETFSSSIILIFRLGTGTGWNDILDAL--VVQPPHCD----PNFGGLPNGNCGFPIGAVFYLVTYIVSVFLIIVNMYIAVLLDNVN 1354 HSP 3 Score: 191.045 bits (484), Expect = 1.286e-48 Identity = 185/669 (27.65%), Postives = 314/669 (46.94%), Query Frame = 1
Query: 301 FC-LEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDI-KSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMY------WINDAQGYKW---PWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSL---TRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSR----SNFDHFWQSVITVFQILTGEDWNEEMYNGI-------RSFGGV-NG-----LGALVSLYFVVLFIVGNY-ILLNVFLAIAVDNLS 2211
FC L+ + VR F V+ + FE IL T+ + L + R L L +F IF++E LK+I +GF+ +Y + WN LD IV + V L N + + +S R R LRPLR +S L +++V+N++ A+ + + ++ +++SI G++LF GK + C N ED K LSP C D+ RWV N NFDN L + Q T EGW +VM I+ Y+ + YFV I++GSFFVLNL +GV+ F+ K+K E+ ++Q ++W++ + + N + + C + + + S QF + IL+++ N ++ +H+ QP I N V V +F E +IKI+A+ L YF KA++ FD +V+ SI+ + L T V++P L VLR R+ R+ ++ Q+ +R L+ ++ SM ++F++ L+ L + I+A++GM FG N+ K+ NF+ F S+I +F++ TG WN+ + + +FGG+ NG +GA ++++V +IV + I++N+++A+ +DN++
Sbjct: 777 FCWLKFRCRVRCF----VEHRYFEWFILFTVMVSSFTLVFEDIH-LHQKPDLERALNFLNFLFAAIFSLEFILKVIGFGFV----SYFTSVWNCLDALIVSVCVSVACLFE---NPNLSVFRSFRTVRGLRPLRAISRLGGMKVVINALFAAIPGIGSVLVVSMLFWLMFSISGVQLFAGKFYK-CVN------AEDEK---------------LSPSVIPNKTACLDHP-DYRWVNAN---VNFDNVINGFLALLQVATYEGWMEVMADAVDSTKIDQQPSYEANLIAYAYFVVFIIVGSFFVLNLFVGVIIDNFNTLKKK---YEEINSMGMLLTESQ-----RKWVQILMAAAKRKPPSN----------------------RLRPTDCFR-------------GKLFDLVSSNQFEVFILTVIMCNMGMMMVQHYDQPPLTTV---IGNYVLVGIFLLEAIIKIIAMRL-HYFKKAWSIFDFVVVVSSIVGMYLGMSTESAVVSPGLLRVLRVFRVARLLRVVQFAKRIRQLLVAIIISMPALFNIGTLLFLVMFIYAIIGMSSFG---NIKKQGALNDLVNFETFSSSIILIFRLGTGTGWNDILDALVVQPPHCDPNFGGLPNGNCGFPIGA---VFYLVTYIVSVFLIIVNMYIAVLLDNVN 1354 HSP 4 Score: 128.257 bits (321), Expect = 1.877e-29 Identity = 150/662 (22.66%), Postives = 271/662 (40.94%), Query Frame = 1
Query: 364 FEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIV-LCSIIELSLTRPKVINPIGLSV---LRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKY----NLDKKSRS-----------------------NFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSL----YFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND 2244
F+ +I I N VVL M Y G + +L+ L +F +F +E +KI ++G + Y+ N WN+ D I+I V L T + R R+LR L L ++ ++ +I ++ P+F+I ++ ++ +++++GM +F P G G RW NF +F + + VF+ + E W + + W ++F+ +++G+F VLNL + +L F+K++E + R + + L + K + + N + R I +D + PE M C + F + R R + + ++FIL +V T+V H Q L+ + N +F A+F+ E ++K++ G YF+ +N D IV +C + P LSV R R LR + ++ ++ L ++ I S+L++ LF ++F++ G+Q+F GK+ N + + S NFD+ + + Q+ T E W E M + + S +L YFVV IVG++ +LN+F+ + +DN + + EE+N
Sbjct: 482 FDGIIAGLILLNTVVLTM---YYHGMPDDLTFVLDILNAIFTGLFILEMIVKIFAFGLV----KYICNKWNLFDSVIIITSAVAYFL-----GTSTGVSIFRILRLLRVLYLAQSWETMAKLIRAIAHSVDPIFNITCILGVIIYVFAVVGMRVF------------------GPHYTAEAFGSRG----------------------IPRW--------NFTDFTHSFMMVFRILCSE-WVEPL-WDCMRVTNTAALLFFLPALIVGNFIVLNLFVALLLNSFAKKEEDLHR----EASEQPYVNPCSCLAHLTRTRKTRMYYTQAVNNNKNTKRYI-VEID-DCFPECC---MNACGCTSGQQHFCWLKFRCRVRCFVEHRYFEWFILFTVMVSSFTLVFEDIHLHQKPDLERALNFLNFLFAAIFSLEFILKVIGFGFVSYFTSVWNCLDALIVSVCVSVACLFENPN------LSVFRSFRTVRGLRPLRAISRLGGMKVVINALFAAIPGIGSVLVVSMLFWLMFSISGVQLFAGKFYKCVNAEDEKLSPSVIPNKTACLDHPDYRWVNANVNFDNVINGFLALLQVATYEGWMEVMADAVDSTKIDQQPSYEANLIAYAYFVVFIIVGSFFVLNLFVGVIIDNFNTLKKKYEEINS 1066 HSP 5 Score: 93.2041 bits (230), Expect = 1.111e-18 Identity = 74/279 (26.52%), Postives = 131/279 (46.95%), Query Frame = 1
Query: 3589 RYKMWSVVCSKKFEYV--------ILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGK--IALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
+Y S CS E++ I LIL NT+ L + P T LDILN IFT +F LE I+K+ AF Y + WN+FD ++++ S V +G + +SI FR+ R++R++ L +++ KL+ S + + ++ ++ +++AV+GM++FG A I R NF F + +++FR E W E + C + A +F+ ++ +F+++NLFVA+++++F
Sbjct: 462 KYPRLSRACSALVEFIQRPLFDGIIAGLILLNTVVLTMYYHGMPDDLTFVLDILNAIFTGLFILEMIVKIFAFGLVKYICNKWNLFDSVIIITSAVAYF-----------LGTSTGVSI--FRILRLLRVLYLAQSWETMAKLIRAIAHSVDPIFNITCILGVIIYVFAVVGMRVFGPHYTAEAFGSRGIPR-WNFTDFTHSFMMVFRILCSE-WVEPLWDCMRVTNTA----------------------ALLFFLPALIVGNFIVLNLFVALLLNSF 703 HSP 6 Score: 88.5817 bits (218), Expect = 2.623e-17 Identity = 82/308 (26.62%), Postives = 140/308 (45.45%), Query Frame = 1
Query: 3589 RYKMWSVVCSKKFEYVILSLILANTLCLA---ARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVA--LLIVMLFFI-YAVIGMQMF-GKI--ALNNTDSSIS--------------------RNNNFQTFPAAVLVLFRSATGESWQEIM---LSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDW 4416
R ++ V + FE+ IL ++ ++ L Q+P L+ LN +F +F+LEFILK+ F F +YF+ WN D ++V + S + + + +S+ FR FR +R ++ L + + F A+P + L++ MLF++ +++ G+Q+F GK +N D +S N NF L L + AT E W E+M + T D++ E + +AY YF+ F ++ SF ++NLFV VI+DNF+ L + +
Sbjct: 783 RCRVRCFVEHRYFEWFILFTVMVSSFTLVFEDIHLHQKPDL-ERALNFLNFLFAAIFSLEFILKVIGFGFVSYFTSVWNCLDALIV-----------SVCVSVACLFENPNLSV--FRSFRTVRGLRPLRAISRLGGMKVVINALFAAIPGIGSVLVVSMLFWLMFSISGVQLFAGKFYKCVNAEDEKLSPSVIPNKTACLDHPDYRWVNANVNFDNVINGFLALLQVATYEGWMEVMADAVDSTKIDQQPSYE---------------ANLIAYAYFVVFIIVGSFFVLNLFVGVIIDNFNTLKKKY 1061 HSP 7 Score: 57.7658 bits (138), Expect = 6.181e-8 Identity = 74/284 (26.06%), Postives = 134/284 (47.18%), Query Frame = 1
Query: 2578 SAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKS---HK-------NIPSVENRTWEN---------NP----LNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDY 3360
++ + R+FC ++ H YF IV + ILV+ ++L DP + +YIFT ++T+E+ K+I+ GF+ A+ R+T+N LD LVVF++ +S D+ ++S ++ LRVLR R + A+ KGL+ +V ++ ++K + ++++ + + A++ +QLF G +K ET IN S H+ S R N NP N+D++ ++ F + T + W L + + + E Y
Sbjct: 39 ASLLCLGPVHPLRMFCILLITHPYFEIIVTLVILVNCIILGLNDPPEEA----------EYIFTAIYTLEMICKIISRGFVKDSYAYLRDTWNWLDSLVVFLSYLSLAPDI-------ASLSGIRTLRVLRAFRTISAL---KGLRAMVNSLLRSLKLLTDVLVLFLFSLCVLALIGLQLFTGEL-----RNKCVLETANATTINNPSSWYHREGEPLLCGFSSTAGRCPANYTCVAHVGPNPDHGFTNFDDIGWSLVMAFQILTMDFWENLYDRVLRSMGEWY 297 HSP 8 Score: 50.447 bits (119), Expect = 8.816e-6 Identity = 44/177 (24.86%), Postives = 76/177 (42.94%), Query Frame = 1
Query: 3574 PQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKN----YFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF 4092
P LR ++ FE ++ +IL N + L + Y IFT ++TLE I K+ + F Y D WN D +VV SY+ + S++ R RV+R + +S +R ++ + ++S + L V +L + + A+IG+Q+F
Sbjct: 46 PVHPLRMFCILLITHPYFEIIVTLVILVNCIILGLNDPPEEAEY---------IFTAIYTLEMICKIISRGFVKDSYAYLRDTWNWLDSLVVFLSYLSL--------------APDIASLSGIRTLRVLRAFRTISALKGLRAMVNSLLRSLKLLTDVLVLFLFSLCVLALIGLQLF 199
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Nematostella
Match: EDO36844 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHI0]) HSP 1 Score: 223.787 bits (569), Expect = 1.939e-58 Identity = 177/570 (31.05%), Postives = 301/570 (52.81%), Query Frame = 1
Query: 2581 AFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDP-IRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSS-KLTNETCKGQFINYKSHKNIPSVENR-TWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQK--------EGESEYKNCELSKNQRKCI---EFALKARPRKRYTPQGHLRYKMWSVVCSKK-FEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNN---TDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTD 4236
+ ++F+ N+FR+ + + +F VL+ IL++ V++A E P + S ++++ Y+F +FTIE+ +K+IA G + P A+ R+ +N++D +V ++ V + +N + +++ R LR LRPLR I+RA GLK VV+ ++ ++K IG I+L+ +F ++ VQLFKG+F+ C+D++ +T +T +EN +W N N+DN+ +LTLFV +T +GW ++Y IDA D P+ N+ + I++V ++++ F ++N+ VG V+ FQK + E K + + R+ I E + PR R K VC+ F+ I ++I N LC+A QQP T L N +FT VF LE ILK+ A K Y D WN D ++V+ S V I + + I R+ R+ R++KLL + IRKLL T ++ + + +L +++FFI++ +G+++FGKI T + + NF++F A+L LFR +TG++W I+ D
Sbjct: 910 SLYVFAPDNRFRMLNKELYQNKWFDRTVLLFILLNCVVMALEGPSVLPGSLERRVIDICMYVFLGIFTIEMMVKVIALGLWIGPDAYLRSGWNVMDGFLVVISWVDVIV-TATTNGQNSILGVLRVFRALRTLRPLRVISRAPGLKIVVETLISSLKPIGNIVLIAATFFIIFGILGVQLFKGKFHYCTDATVPVTTKT--------------ECLENGGSWVNREYNFDNLAKALLTLFVFSTKDGWVNIMYDGIDAVGIDKQPIRNHARYNVIYFVGFLLLAGFVVLNMLVGVVVENFQKCRTLIEMEKKIDEEKKNKKEEKMRREIAEDEALSEHYPRPR---------KFIHAVCTHGYFDLGIAAVIALNVLCMALEHYQQPDGLTAFLKCANYVFTAVFILEAILKIFALGIKRYIKDRWNQLDMLIVILSIVGIALEEMTMELPINP-----TIIRVMRVLRIARVLKLLKTAEGIRKLLDTVAQALPQVGNLGMLFLLMFFIFSALGIELFGKIDCEKPGITCQGMDEHANFRSFGIAMLTLFRISTGDNWNGILKDTISPD 1450 HSP 2 Score: 167.162 bits (422), Expect = 3.241e-41 Identity = 91/241 (37.76%), Postives = 146/241 (60.58%), Query Frame = 1
Query: 1507 MKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLD------KKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLS 2211
+ SK F +I+ +F+NT+ + E++ QP + +I N +F A+F EM++K++ LG Y AFN FD IV+ S++EL + G+SVLR RLLRVFKL ++ +LR + ++ +M ++ + L L+ +F+ ++LGM +FGGKY + SR+NFD + +++TVFQ+LT EDWN MY+G+R+ G LYF++L +GNYIL N+ +AI V+ +
Sbjct: 408 VDSKWFMYVIMGAIFVNTLTMGIEYYGQPQKMTDVLEIFNYIFTAIFGIEMIMKLIGLGFYGYIKDAFNIFDGTIVIISVVELFGD-----DDSGISVLRSFRLLRVFKLVRFLPALRRQLLVMIHTMDNVMTFLALLVIFMFTASILGMNLFGGKYRFPNDEGVMETSRANFDDLFWAIVTVFQVLTQEDWNIVMYDGMRATSKWAG------LYFILLMTIGNYILFNLLVAILVEGFA 637 HSP 3 Score: 158.303 bits (399), Expect = 1.513e-38 Identity = 108/334 (32.34%), Postives = 168/334 (50.30%), Query Frame = 1
Query: 271 CSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDI----KSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLH----ATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQG---------YKWPWIYFVSLILLGSFFVLNLILGVLSGEFSK 1221
C S + D SL+ N R+ + +K F+ +LL I NCVV+ + P S R+++ VF+ IFTIE +K+I+ G + +AYLR+ WN++D F+V+I V I+TA + N + I + RA R LRPLR++S P L+IV+ ++I+++KP+ +I L+ +I+ I+G++LF GK H AT E +E+ G SW+ ++ NFDN A+LT+F T +GW +MY DA G ++ IYFV +LL F VLN+++GV+ F K
Sbjct: 902 CCSKRADWSLYVFAPDNRFRMLNKELYQNKWFDRTVLLFILLNCVVMALEGPSVLPGS-LERRVIDICMYVFLGIFTIEMMVKVIALGLWIGPDAYLRSGWNVMDGFLVVISWVDVIVTATT-NGQNSILGVLRVFRALRTLRPLRVISRAPGLKIVVETLISSLKPIGNIVLIAATFFIIFGILGVQLFKGKFHYCTDATVPVTTKTECLEN-----------------------GGSWVNRE--------------YNFDNLAKALLTLFVFSTKDGWVNIMYDGIDAVGIDKQPIRNHARYNVIYFVGFLLLAGFVVLNMLVGVVVENFQK 1196 HSP 4 Score: 113.235 bits (282), Expect = 8.542e-25 Identity = 64/193 (33.16%), Postives = 112/193 (58.03%), Query Frame = 1
Query: 1522 FFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSL---TRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--------RSNFDHFWQSVITVFQILTGEDWN 2067
F + I +++ LN + + EH++QP L +F AN VF A+F E ++KI ALG+ Y +N+ D+ IV+ SI+ ++L T INP + V+R R+ RV KL + +R L++ + +++ + +L +L L IF+ LG+++F GK + +K +NF F +++T+F+I TG++WN
Sbjct: 1249 FDLGIAAVIALNVLCMALEHYQQPDGLTAFLKCANYVFTAVFILEAILKIFALGIKRYIKDRWNQLDMLIVILSIVGIALEEMTMELPINPTIIRVMRVLRIARVLKLLKTAEGIRKLLDTVAQALPQVGNLGMLFLLMFFIFSALGIELF-GKIDCEKPGITCQGMDEHANFRSFGIAMLTLFRISTGDNWN 1440 HSP 5 Score: 103.99 bits (258), Expect = 5.154e-22 Identity = 93/317 (29.34%), Postives = 140/317 (44.16%), Query Frame = 1
Query: 340 ARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFH-IALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQ 1287
A VDSK F +I+ IF N + +G+ G +LE +F IF IE +K+I GF Y+++A+NI D IVII VV + + I LR+FR+LR +LV LP+L+ L +I M + +ALLV F+ SI+GM LF GK P DEG + NFD+ A++TVFQ +T E W VMY A KW +YF+ L+ +G++ + NL++ +L F+ D + + ++ R++
Sbjct: 405 ASSVDSKWFMYVIMGAIFVNTLTMGIEY---YGQPQKMTDVLEIFNYIFTAIFGIEMIMKLIGLGFY----GYIKDAFNIFDGTIVIISVV-----ELFGDDDSGISVLRSFRLLRVFKLVRFLPALRRQLLVMIHTMDNVMTFLALLVIFMFTA-SILGMNLFGGKYRF--------------------------------PNDEGVMETSR---------------ANFDDLFWAIVTVFQVLTQEDWNIVMYDGMRATS-KWAGLYFILLMTIGNYILFNLLVAILVEGFASAPAGYDSEGNYDYPPKSPRRSS 660 HSP 6 Score: 102.834 bits (255), Expect = 1.291e-21 Identity = 75/266 (28.20%), Postives = 120/266 (45.11%), Query Frame = 1
Query: 3604 SVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSI--SRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNF 4395
S V SK F YVI+ I NTL + + QP+ TD L+I N IFT +F +E I+KL F Y DA+NIFD +V+ S V++ + I+ R FR++R+ KL+ ++R+ L I + + L+V+ F +++GM +FG D + + NF A++ +F+ T E W +M K W YFI I ++++ NL VA++++ F
Sbjct: 406 SSVDSKWFMYVIMGAIFVNTLTMGIEYYGQPQKMTDVLEIFNYIFTAIFGIEMIMKLIGLGFYGYIKDAFNIFDGTIVIISVVELFGDDDS-------------GISVLRSFRLLRVFKLVRFLPALRRQLLVMIHTMDNVMTFLALLVIFMFTASILGMNLFGGKYRFPNDEGVMETSRANFDDLFWAIVTVFQVLTQEDWNIVMYDGMRATSK---------------------WAGL-YFILLMTIGNYILFNLLVAILVEGF 636 HSP 7 Score: 98.2117 bits (243), Expect = 2.912e-20 Identity = 66/248 (26.61%), Postives = 120/248 (48.39%), Query Frame = 1
Query: 655 IKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDP-------KP-------CMVGLGDDGYSCT-GLSPLDEGQSWIC---------KDN--NLTERW-----------VGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQ 1287
+ ++RA RVLRPLR ++ +PS++I++ ++ + L ++ + + I+ I+G++++ G L + C + + + +P C + CT P C + N N+ W + P +FDN +A + +FQ +T+EGWT +MY+I DA G+ W +IYFV LI++GS+F+ NL L V++ +F + K Q+E + RQ++
Sbjct: 1 MTAVRAIRVLRPLRAINRVPSIRILVTLLLDTLPMLGNVLAMCSLIFSIFGIVGVQMWQGVLRSRCVAQLPGNLSANQLNISAFYQPGGSSDLVCSLPENSGDKHCTSAFIPASTAHGRECGLTYEQYSNRSNYTNVCANWNQYYTLCADMGINPLYDAVSFDNILIAWVAIFQVITLEGWTDIMYYIQDAHGF-WNFIYFVVLIVIGSYFMTNLCLVVITTQFQETK---------QRENDLMRQSR 238 HSP 8 Score: 94.3597 bits (233), Expect = 5.189e-19 Identity = 73/265 (27.55%), Postives = 131/265 (49.43%), Query Frame = 1
Query: 1510 KSKQFFILILSLVFLNTMVLCTEHHKQ-PLWLDS-FQDIANIVFVALFTFEMVIKILALGL----GEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLR---CARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYN--------LDKKSRS------------NFDHFWQSVITVFQILTGEDWNEEMYNGIRSFG----GVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDN 2205
++K F +L + LN +V+ E P L+ DI VF+ +FT EM++K++ALGL Y +N D F+V+ S +++ +T L VLR R LR ++ L+ +VE L+ S+K I +++L+ F +IF +LG+Q+F GK++ + K+ NFD+ ++++T+F T + W MY+GI + G + +YFV ++ +++LN+ + + V+N
Sbjct: 929 QNKWFDRTVLLFILLNCVVMALEGPSVLPGSLERRVIDICMYVFLGIFTIEMMVKVIALGLWIGPDAYLRSGWNVMDGFLVVISWVDVIVTATTNGQNSILGVLRVFRALRTLRPLRVISRAPGLKIVVETLISSLKPIGNIVLIAATFFIIFGILGVQLFKGKFHYCTDATVPVTTKTECLENGGSWVNREYNFDNLAKALLTLFVFSTKDGWVNIMYDGIDAVGIDKQPIRNHARYNVIYFVGFLLLAGFVVLNMLVGVVVEN 1193 HSP 9 Score: 71.633 bits (174), Expect = 3.746e-12 Identity = 63/260 (24.23%), Postives = 113/260 (43.46%), Query Frame = 1
Query: 328 RIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVD---IKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVM 1098
R FI + F++ I I N + + + Y D + L+ VF +F +EA LKI + G Y+++ WN LD IVI+ +V L ++ ++ I+ +R R+ R L+L+ ++ +L+++ A+ + ++ +L + I+S +G+ELF GK+ E P G +C G+ D NF +FG+AMLT+F+ T + W ++
Sbjct: 1237 RKFIHAVCTHGYFDLGIAAVIALNVLCMALEH-YQQPDGLTA--FLKCANYVFTAVFILEAILKIFALGI----KRYIKDRWNQLDMLIVILSIVGIALEEMTMELPINPTIIRVMRVLRIARVLKLLKTAEGIRKLLDTVAQALPQVGNLGMLFLLMFFIFSALGIELF-GKIDC-----------EKP----------GITCQGM------------------------DEHANFRSFGIAMLTLFRISTGDNWNGIL 1443
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Nematostella
Match: EDO35497 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SLD1]) HSP 1 Score: 200.675 bits (509), Expect = 1.026e-54 Identity = 170/547 (31.08%), Postives = 294/547 (53.75%), Query Frame = 1
Query: 2608 KFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDP-IRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRN---EAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSC-SDSSKLTNETC----KGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNN--TDSSISRNNNFQTFPAAVLVLFRSATGESWQEIM 4215
+FR V H F ++LV I+ S +LA E P I + +I++ +FT +FTIE+ +K++A G +L PG + R+ +++LD +V V+ ID++ Y + E + +++ R LR LRPLR I RA GLK VVQ ++ ++K IG +L+ + MF ++ VQLFKG+FY C DS ++ + C +GQ W N N+D++L +++LFVV+T +GW +++ IDA D P+ NY + ++++ ++++ F ++N+ VG V+ FQ+ E + E ++ RK + + + Y G LR K+ + + ++ I ++I N +C++ + P+ + +T N FT VF +E ++K+ A F Y D WN+ D +VL S V I+ + T ++ R+ RV++LVKL +R LL T ++ +P + LL +LFFIY+ +G+Q+FG + ++ +R+ +F+ F A+L LFR ATG++W I+
Sbjct: 7 RFRQRMRAVCSHRAFDYVILVFIIFSCAVLAIEAPDIAEQGLKRQIIDISMLVFTIIFTIEMLIKLVAMGLVLGPGTYLRDGWDVLDGFLVMVSW----IDIIVTYTSHVSPEVLGTLRVFRALRTLRPLRVIRRAPGLKLVVQTLLYSLKPIGNTVLIAAIFFVMFGILGVQLFKGKFYYCEGDSHVISKQECANSTRGQ-----------------WVNRRYNFDDLLQALISLFVVSTKDGWVEIMHHGIDAVDVDVQPIVNYAEWRLVYFIPFLLLGGFLVLNMIVGVVVENFQRCRERMDEE-EQARPHRKGKKARNQMQDSLYYESYGPLRLKIHFICTHRNWDITIAAIICINVICMSLEHYKMPQVFVET---TNYFFTSVFVIEVVVKVIALGFVRYPKDRWNLIDLAIVLLS-VTGIVLELLVKVDHLFNPTVIRTLRVLRITRVLKLVKL---AKGVRSLLDTLFEALPQVPNLGLLFFLLFFIYSCLGIQLFGSLECSHDYPCQGFNRHAHFRDFGTAMLTLFRIATGDNWNGIL 524 HSP 2 Score: 172.17 bits (435), Expect = 5.212e-45 Identity = 166/610 (27.21%), Postives = 287/610 (47.05%), Query Frame = 1
Query: 346 IVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLR---PLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGY---------KWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSI----IELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGG-----KYNLDKKSR-SNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVN 2109
+ + F+ +IL+ I +C VL + P A + +I++ +VF +IFTIE +K+++ G +L YLR+ W++LD F+V++ + I+T S + + +LR FR LR PLR++ P L++V+ +++ ++KP+ + L+ V++ I+G++LF GK Y C G S + Q C N+ +WV NFD+ A++++F T +GW ++M+ DA +W +YF+ +LLG F VLN+I+GV+ F + +E++D E E R ++ G K + D L Y E L + + H I + + I I +++ +N + + EH+K P F + N F ++F E+V+K++ALG Y +N DL IVL S+ +EL + + NP + LR R+ RV KL + +RSL++ L +++ + +L LL L I++ LG+Q+FG Y +R ++F F +++T+F+I TG++W NGI G N
Sbjct: 15 VCSHRAFDYVILVFIIFSCAVLAIEAPDIA-EQGLKRQIIDISMLVFTIIFTIEMLIKLVAMGLVLGPGTYLRDGWDVLDGFLVMVSWIDIIVTYTSHVSPEVLGTLRVFRALRTLRPLRVIRRAPGLKLVVQTLLYSLKPIGNTVLIAAIFFVMFGILGVQLFKGKF---------------------------YYCEGDSHVISKQE--CA-NSTRGQWVNRR---YNFDDLLQALISLFVVSTKDGWVEIMHHGIDAVDVDVQPIVNYAEWRLVYFIPFLLLGGFLVLNMIVGVVVENFQRCRERMD-------EEEQARPHRK--GKKARNQMQDSL-----------YYESYGPL--------------RLKIHFICT------------------HRNWDITIAAIICINVICMSLEHYKMP---QVFVETTNYFFTSVFVIEVVVKVIALGFVRYPKDRWNLIDLAIVLLSVTGIVLELLVKVDHLFNPTVIRTLRVLRITRVLKLVKLAKGVRSLLDTLFEALPQVPNLGLLFFLLFFIYSCLGIQLFGSLECSHDYPCQGFNRHAHFRDFGTAMLTLFRIATGDNW-----NGILKVGPTN 530 HSP 3 Score: 93.5893 bits (231), Expect = 2.831e-19 Identity = 72/255 (28.24%), Postives = 130/255 (50.98%), Query Frame = 1
Query: 1615 DIANIVFVALFTFEMVIKILALGL----GEYFSKAFNKFDLFIVLCSIIELSLTRPKVINP--IG-LSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYN--------LDKKS------------RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFG----GVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAE 2286
DI+ +VF +FT EM+IK++A+GL G Y ++ D F+V+ S I++ +T ++P +G L V R R LR ++ + L+ +V+ LL S+K I + +L+ +F V+F +LG+Q+F GK+ + K+ R NFD Q++I++F + T + W E M++GI + + +YF+ ++G +++LN+ + + V+N +C+ EEE A
Sbjct: 54 DISMLVFTIIFTIEMLIKLVAMGLVLGPGTYLRDGWDVLDGFLVMVSWIDIIVTYTSHVSPEVLGTLRVFRALRTLRPLRVIRRAPGLKLVVQTLLYSLKPIGNTVLIAAIFFVMFGILGVQLFKGKFYYCEGDSHVISKQECANSTRGQWVNRRYNFDDLLQALISLFVVSTKDGWVEIMHHGIDAVDVDVQPIVNYAEWRLVYFIPFLLLGGFLVLNMIVGVVVENFQ------------RCRERMDEEEQAR 296 HSP 4 Score: 51.2174 bits (121), Expect = 4.321e-6 Identity = 75/296 (25.34%), Postives = 127/296 (42.91%), Query Frame = 1
Query: 232 ALKDREGAKHR-QLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNR-PYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVII---GVVTEILTAIS--FNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVM 1098
A R+G K R Q+ SL E P+R+ I I + +++ I I N + + + P +TN F +F IE +K+I+ GF+ Y ++ WN++D IV++ G+V E+L + FN V I++LR R+ R L+LV ++ +L+++ A+ + ++ LL F L IYS +G++LF G L + Y C G + +F +FG AMLT+F+ T + W ++
Sbjct: 295 ARPHRKGKKARNQMQDSLY-------YESYGPLRLKIHFICTHRNWDITIAAIICINVICMSLEHYKMPQVFVETTNYF-------FTSVFVIEVVVKVIALGFV----RYPKDRWNLIDLAIVLLSVTGIVLELLVKVDHLFNPTV-IRTLRVLRITRVLKLVKLAKGVRSLLDTLFEALPQVPNLGLLFFLLFFIYSCLGIQLF-GSLECS----------------------HDYPCQGF------------------------NRHAHFRDFGTAMLTLFRIATGDNWNGIL 524
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Nematostella
Match: EDO35661 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKR1]) HSP 1 Score: 204.142 bits (518), Expect = 1.518e-52 Identity = 204/696 (29.31%), Postives = 340/696 (48.85%), Query Frame = 1
Query: 2632 VVCHSYFGNIVLVCILVSSVMLAAEDP-IRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTF-------QKEGESEYKNCELSKNQRKCIEFALKARPRKRY-TPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDF----IVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEI----MLSCTGTDEKSRCEIXXXXXXXXXXHDFCGS-WVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRR 4662
+V H F I+L I SS+ LA ED + + ++L + +F +FT+E+ LK I GF + N +N+LD ++V V S + + + N+ I+ ++ LR LR RPLRAI+R +G+K V+ ++ A+ IG ++LV + +F++M VQ+F G+F C D E C + +K + WEN+ +N+D V G L L VATFEGW ++ ++DA K D P+ N +F+V +II+ FF +N+F+G +I F + G + +N ++ A +P+KR PQ + +++ +V S+KFE I+ I N + + + ++ ILN+IFT VF LE IL++ A K YF + WN+FDF ++G V+ + + I+ S F R F R IR+LL++ + S AL + L+ ++ FIYA+IGM +FG + +++ NF+TF ++ ++LFR T W +I M+S D R CG+ ++A Y SF +I ++IN+++AVI++N++ + I + ++ F W +D A I + D+ + ++ L P+ AC L N+PL + L ALV+R
Sbjct: 823 LVEHKVFEGIILFLIAASSISLAFEDVYLDSKPTLKQVLQILNILFAVIFTVEMLLKWIGLGF----KTYFTNPWNILDFVIVIV---SIMVSLATIFG-NDQIAFIRSLRTLRAFRPLRAISRFEGMKVVITSLLHAIPGIGNVLLVCLMFWLIFSIMGVQIFGGKFGKCVDEG---GEKCPASVV---PNKTVCLSNGYRWENSNINFDTVDQGFLALLQVATFEGWMEIMEDAVDATKIDEQPIEENNVSAYLFFVVFIILGTFFTLNLFIGVIIDNFNQLKQQMEAVGSMDVFLTSTQRNWMNALKSAATKKPKKRIRRPQNKFQGELYDMVQSRKFEVFIMLFITINMVVMMVQHYDHLAVWSK--QILNLIFTSVFILEAILRIIALR-KGYFLNPWNVFDFVIVISSIIGIIVENLQTSLVINPSLLRVVRVFRVGRLLRFFEAAR---------GIRRLLFSLVISTPALFNIGALLFLIIFIYAIIGMSIFGHV---KKTEALNDVVNFETFGSSFVLLFRLMTSAGWNDILDPLMISEPDCDPNYR----------GLPSGNCGNKYMAPIYLGSFVVIIFLILINMYIAVILENYNQVMEQEKIGITNEDIELFYQMWELFDPNATQYIPYADLSDFVHQMEGNLRIPK--PNKAACALL---NIPLVKGDKIHCLDLLQALVKR 1474 HSP 2 Score: 174.481 bits (441), Expect = 1.678e-43 Identity = 174/660 (26.36%), Postives = 309/660 (46.82%), Query Frame = 1
Query: 325 VRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNST-NRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDA---------QGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNP-EAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQ-PLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIEL---SLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRS-----NFDHFWQSVITVFQILTGEDWNEEM-------------YNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDN 2205
+R + R+V+ K FE +IL I A+ + L Y DS T ++L+ L ++F VIFT+E LK I GF Y N WNILDF IVI+ ++ + T + I+SLR R RPLR +S +++V+ S++ A+ + ++ L+ +I+SI+G+++F GK C + E + C + + C L G W +++N+ NFD L + Q T EGW ++M DA + +++FV I+LG+FF LNL +GV+ F++ K++++ + ++N W+ N S ++ + QN + + +M +SR +F + I+ + +N +V+ +H+ +W + I N++F ++F E +++I+AL G YF +N FD IV+ SII + +L VINP L V+R R+ R+ + + +R L+ L+ S ++F++ L+ L I I+A++GM +FG KK+ + NF+ F S + +F+++T WN+ + Y G+ S G G + +Y ++ IL+N+++A+ ++N
Sbjct: 816 MRYKVRRLVEHKVFEGIILFLIAASSISLAFEDVYL--DSKPTLKQVLQILNILFAVIFTVEMLLKWIGLGF----KTYFTNPWNILDFVIVIVSIMVSLATIFGNDQIAFIRSLRTLRAFRPLRAISRFEGMKVVITSLLHAIPGIGNVLLVCLMFWLIFSIMGVQIFGGKF-GKCVD-------EGGEKCPASVVPNKTVC-----LSNGYRW--ENSNI------------NFDTVDQGFLALLQVATFEGWMEIMEDAVDATKIDEQPIEENNVSAYLFFVVFIILGTFFTLNLFIGVIIDNFNQLKQQMEAVGSMDVFLTSTQRN--------WM----------NALKSAATKKPKKRIRRPQNKFQGELYDMVQSR--------------------------KFEVFIMLFITINMVVMMVQHYDHLAVWS---KQILNLIFTSVFILEAILRIIALRKG-YFLNPWNVFDFVIVISSIIGIIVENLQTSLVINPSLLRVVRVFRVGRLLRFFEAARGIRRLLFSLVISTPALFNIGALLFLIIFIYAIIGMSIFGHV----KKTEALNDVVNFETFGSSFVLLFRLMTSAGWNDILDPLMISEPDCDPNYRGLPS--GNCGNKYMAPIYLGSFVVIIFLILINMYIAVILEN 1388 HSP 3 Score: 174.096 bits (440), Expect = 2.056e-43 Identity = 124/403 (30.77%), Postives = 198/403 (49.13%), Query Frame = 1
Query: 289 DRSLFCLEKKNPVRIFIARIVDSK-PFEV-----LILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEM---------------MEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPW--IYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWI-----EKADELSDEENDGNSDDYREISTSLDHNQNPEA 1413
+SL+ +NP+R F +++ ++ P ++ +LLTI NCV L M P E+ E VF I+TIE KII+ GF LH+ AYLR+ WN LDF +VI+G VT IS + ++ + FRV R LR +S + L+ ++N+++ +MK L+ + +L F + I+++IGM+LF+G+L C V + +ED +P + G +C ++ C L PN G T+FD+FG A+LT FQ +T++ W V N+ PW +YF +I G FF++NL+L V++ + E K + E ++ +E KR Y + I + D + DE N D ++ S + EA
Sbjct: 21 SKSLYLFGPENPIRQFSLKLITNQYPLQLHNRHMFVLLTILVNCVFLAMTNPP------------EQPEYVFAAIYTIEMFCKIIAKGFALHRYAYLRDKWNWLDFIVVILGNVT-----ISPDVA-NLSGIPTFRVFRALRTISAVKGLKAMVNTLLVSMKMLWDVMVLTLFFICIFALIGMQLFIGELRNKCALPVPENLSVPYRTYASNSSIWYLEDNEPILCGNTTGSRTCP--------TNYTC----LPHAGGNPNFGYTSFDHFGWALLTGFQLITLDFWENVY---NNVIYTMGPWYVVYFAVVIFFGPFFLVNLVLAVVAASYENEV-KASKMETEEERKEQKRVASSYSVRRASILSIVYGQGDVIPDEPNSKGLYDIPVVTCSEVTKSDEEA 389 HSP 4 Score: 130.568 bits (327), Expect = 4.237e-30 Identity = 106/356 (29.78%), Postives = 177/356 (49.72%), Query Frame = 1
Query: 1198 VLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWI---------------EKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXS--------VIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTR--PKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDK----KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLN 2178
V E +K E + FQ +E+ QNQ+ ++ WI E A ++ + N + +I S N N + I KS + +K+ K R+ ++ + K I I+ + LNT+V+ EH + L + +I+N VF +F EM++K++ALG Y A+N FD +V+ SI++ + + P G+SVLR RLLRV KL + W+++ SL+ + KS+ ++ +L +++ + + IFA++GMQ+ G Y DK R NF F S + +F++L GE W E +++ + + G V L FV FI+GN+I+LN
Sbjct: 377 VTCSEVTKSDE--EALSVFQIRQESGIQNQNLTLHQNWIGSRQPSSVTLPSLKPEHALHMNGSQRS-NLNHTSDIIGSQKSNLNNASQIISSHKSSLNLSVKKEEKKRSSIMARRWKRFRRRLLKFTNGKVMEIFIIVCILLNTLVMSIEHPRLEDPLLTVVNISNEVFTFIFLLEMILKLIALGFLGYIRVAWNIFDGIVVIISIVDFIVNKFVPDA-GGTGISVLRTFRLLRVLKLAKSWSTMNSLLATIGKSLGALGNLTVILAIIVYIFAVMGMQLLGNSYTPDKFGGSIPRWNFKDFPHSFMMIFRVLCGE-WIEPLWDCMLATGPV------AMLLFVPAFILGNFIILN 721 HSP 5 Score: 98.5969 bits (244), Expect = 2.555e-20 Identity = 73/207 (35.27%), Postives = 107/207 (51.69%), Query Frame = 1
Query: 3616 SKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNI---IFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFG-KIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSC 4224
K E I+ IL NTL ++ + P+ L ++NI +FT +F LE ILKL A F Y AWNIFD IVV+ S VD G T I+ R FR++R++KL ++ LL T KS AL + +++ ++ +I+AV+GMQ+ G + SI R NF+ FP + +++FR GE W E + C
Sbjct: 502 GKVMEIFIIVCILLNTLVMSI---EHPRLEDPLLTVVNISNEVFTFIFLLEMILKLIALGFLGYIRVAWNIFDGIVVIISIVD----FIVNKFVPDAGGT---GISVLRTFRLLRVLKLAKSWSTMNSLLATIGKSLGALGNLTVILAIIVYIFAVMGMQLLGNSYTPDKFGGSIPR-WNFKDFPHSFMMIFRVLCGE-WIEPLWDC 696 HSP 6 Score: 85.1149 bits (209), Expect = 2.934e-16 Identity = 64/239 (26.78%), Postives = 115/239 (48.12%), Query Frame = 1
Query: 1600 LDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFK---LTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYN--LDK------------------------KSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFG------GVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLS 2211
L I NI+F +FT EM++K + LG YF+ +N D IV+ SI+ ++ + ++ +R R LR F+ + ++ ++ LL ++ I ++LL+ +F +IF+++G+Q+FGGK+ +D+ S NFD Q + + Q+ T E W E M + + + N + A L+FVV I+G + LN+F+ + +DN +
Sbjct: 857 LKQVLQILNILFAVIFTVEMLLKWIGLGFKTYFTNPWNILDFVIVIVSIM---VSLATIFGNDQIAFIRSLRTLRAFRPLRAISRFEGMKVVITSLLHAIPGIGNVLLVCLMFWLIFSIMGVQIFGGKFGKCVDEGGEKCPASVVPNKTVCLSNGYRWENSNINFDTVDQGFLALLQVATFEGWMEIMEDAVDATKIDEQPIEENNVSAY--LFFVVFIILGTFFTLNLFIGVIIDNFN 1090 HSP 7 Score: 70.4774 bits (171), Expect = 9.373e-12 Identity = 77/314 (24.52%), Postives = 126/314 (40.13%), Query Frame = 1
Query: 1630 VFVALFTFEMVIKILALGLG----EYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKY----------NLDKKSRS-----------------------------------------NFDH-----FWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGM-VKDEKLANGGVGDACSITNHPSTCGL 2388
VF A++T EM KI+A G Y +N D +V+ + +S P V N G+ R R LR + L+++V LL SMK ++ +++L FI IFAL+GMQ+F G+ NL R+ NF + F +++T FQ++T + W E +YN + + +G +YF V+ G + L+N+ LA+ + N+ K ++EEE E V+ + + G I + P++ GL
Sbjct: 79 VFAAIYTIEMFCKIIAKGFALHRYAYLRDKWNWLDFIVVILGNVTIS---PDVANLSGIPTFRVFRALRTISAVK---GLKAMVNTLLVSMKMLWDVMVLTLFFICIFALIGMQLFIGELRNKCALPVPENLSVPYRTYASNSSIWYLEDNEPILCGNTTGSRTCPTNYTCLPHAGGNPNFGYTSFDHFGWALLTGFQLITLDFW-ENVYNNV-----IYTMGPWYVVYFAVVIFFGPFFLVNLVLAVVAASYE---------NEVKASKMETEEERKEQKRVASSYSVRRASILSIVYGQGDVIPDEPNSKGL 371 HSP 8 Score: 69.707 bits (169), Expect = 1.594e-11 Identity = 48/163 (29.45%), Postives = 85/163 (52.15%), Query Frame = 1
Query: 343 RIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNT-KVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELF 828
+ + K E+ I++ I N +V+ + P + I + VF IF +E LK+I+ GFL Y+R AWNI D +VII +V I+ + I LR FR+LR L+L ++ +L +I ++ L ++ +++ +V I++++GM+L
Sbjct: 498 KFTNGKVMEIFIIVCILLNTLVMSIEHPRLEDPLLTVVNISNE---VFTFIFLLEMILKLIALGFL----GYIRVAWNIFDGIVVIISIVDFIVNKFVPDAGGTGISVLRTFRLLRVLKLAKSWSTMNSLLATIGKSLGALGNLTVILAIIVYIFAVMGMQLL 653 HSP 9 Score: 55.8398 bits (133), Expect = 2.238e-7 Identity = 57/201 (28.36%), Postives = 100/201 (49.75%), Query Frame = 1
Query: 2548 KTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNI------VLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRF 3132
KT+ + + ++F N R F ++ + Y + VL+ ILV+ V LA +P +Y+F ++TIE+ K+IA GF LH A+ R+ +N LD +VV + V+ + D+ I ++ R LR I+ KGLK +V ++V++K + +M++T + +FA++ +QLF G
Sbjct: 12 KTQVYRFNRSKSLYLFGPENPIRQFSLKLITNQYPLQLHNRHMFVLLTILVNCVFLAMTNPPEQP----------EYVFAAIYTIEMFCKIIAKGFALHRYAYLRDKWNWLDFIVVILGNVTISPDVANL----SGIPTFRV------FRALRTISAVKGLKAMVNTLLVSMKMLWDVMVLTLFFICIFALIGMQLFIGEL 192
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Medaka
Match: cacna1c (voltage-dependent L-type calcium channel subunit alpha-1C [Source:NCBI gene;Acc:101173517]) HSP 1 Score: 1523.84 bits (3944), Expect = 0.000e+0 Identity = 874/1626 (53.75%), Postives = 1132/1626 (69.62%), Query Frame = 1
Query: 298 LFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT-------AISFNTKV---DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN-EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQN--------PEAAIE----------EMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND----------AKCKNNKSEEENAE--MVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKK 5049
L CL KNP+R IV+ KPFE++IL+TIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL A K D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TC +N T E P PC G G CT G C+ W GPNDGITNFDNF AMLTVFQ +TMEGWT V+YW+NDA Y+WPW+YFV+LI++GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E + DD + + S+ ++N P +E ++KS+ + +R+ + R R+ + KS+ F+ L++ LVFLNT+ + +EHH+QP WL QDIAN V +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + A+ + K EEN + + + + ++ + + + G + + + CG ENE D + ++EEE G + PR ++K ++ +P AFF+FS TNKFRV CH +V H+ F N++L IL+SS+ LAAEDP++ S RN+IL Y D++FT +FTIEI LKM AYG LH G+FCRN FN+LDL+VV V+L+S I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+F+ C+DSSK T C+G +I YK P R WEN+ N+D+VL GM+ LF V+TFEGWPGLLY++ID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ +LIL NT+CLA + Q K + D ++ILN++FT +FT+E ILKL AF + YFSD WN+FDF++V+GS +D+I+S N +S+ + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL + S I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C+ CE + ++ + CGS A YF+SFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR+++KK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK Q + +P TA L L RT + IG E + G N E+E K
Sbjct: 143 LLCLTLKNPIRRACISIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGATPIGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCVHNHTGLNAEEKPAPCAPD-GAYGRHCT-----QNGTQ--CRVG-----WEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWVNDAVDYRWPWVYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGLDDDKPRNLSMPASENESVNTDNPPGGDVEGETCCTRLAIRISKSKFSRYSRRWNRLFRRKCRAAV---KSQVFYWLVIFLVFLNTLTIASEHHRQPQWLTDVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEAKERKKLARLASPKKHEENEKPPLEEKKSEKIELKSITSDGETNPATKISMDDCCG----------DENEEKNPYPANDYIGDDDEEEPEMPVGPR-----PRPLSDIHLKEKAVPMPEARAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFFYCTDSSKQTQAECRGSYIMYKDGDVGKPGRSPRVWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQTKNFNDAMNILNMLFTGLFTVEMILKLIAFKPRGYFSDPWNVFDFLIVIGSIIDVILSEINGLQNSE--ENARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDL-SQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACS---PNRPCEKGSTNENSTASEE-CGSQFAIIYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTDGN-----LEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE-QGLVGKVPPKTA---------LSLQAGLRTLHD-IGPEIRRAISGDLNVEEEMDK 1707 HSP 2 Score: 98.5969 bits (244), Expect = 6.896e-20 Identity = 77/284 (27.11%), Postives = 133/284 (46.83%), Query Frame = 1
Query: 292 RSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIY 1143
R+ F N R+ +IV+ F LIL I + + L P + + N+IL + VF +FTIE LK+ +YG LH+ ++ RN +NILD +V + +++ + + + N +K LR RVLRPLR ++ L+ V+ + A++ + +I ++ L +++ IG++LF GK C ++ + + + + + D G SP + W D NFD+ M+ +F T EGW ++Y D+ IY
Sbjct: 913 RAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDP--VKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFF-YCTDS-SKQTQAECRGSYIMYKDGDVGKPGRSP----RVWENSD--------------FNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIY 1171
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Medaka
Match: cacna1c (voltage-dependent L-type calcium channel subunit alpha-1C [Source:NCBI gene;Acc:101173517]) HSP 1 Score: 1515.36 bits (3922), Expect = 0.000e+0 Identity = 879/1641 (53.56%), Postives = 1131/1641 (68.92%), Query Frame = 1
Query: 298 LFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT-------AISFNTKV---DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN-EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDE-ENDGNSDDY-REISTSLDHNQ-----NPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND----------AKCKNNKSEEENAE--MVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVG--------------------------KTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKK 5049
L CL KNP+R IV+ KPFE++IL+TIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL A K D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TC +N T E P PC G G CT G C+ W GPNDGITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E E +G DD R +S N+ NP E ++ C ++ + R+ +RR +KS+ F+ L++ LVFLNT+ + +EHH+QP WL QDIAN V +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + A+ + K EEN + + + + ++ + + + G + + + CG ENE D + ++EEE G + PR ++K ++ +P AFF+FS TNKFRV CH +V H+ F N++L IL+SS+ LAAEDP++ S RN+IL Y D++FT +FTIEI LKM AYG LH G+FCRN FN+LDL+VV V+L+S I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+F+ C+DSSK T C+G +I YK P R WEN+ N+D+VL GM+ LF V+TFEGWPGLLY++ID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ +LIL NT+CLA + Q K + D ++ILN++FT +FT+E ILKL AF + YFSD WN+FDF++V+GS +D+I+S N + SS + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL + S I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C+ CE + ++ + CGS A YF+SFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR+++KK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK Q + +P TA S+Q GL RT + IG E + G N E+E K
Sbjct: 143 LLCLTLKNPIRRACISIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGATPIGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCVHNHTGLNAEEKPAPCAPD-GAYGRHCT-----QNGTQ--CRVG-----WEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGLDDDKPRNLSMPASENESVNTDNPPGGDVE-GETCCTRLARYSRRWNRLFRRKCRAAVKSQVFYWLVIFLVFLNTLTIASEHHRQPQWLTDVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEAKERKKLARLASPKKHEENEKPPLEEKKSEKIELKSITSDGETNPATKISMDDCCG----------DENEEKNPYPANDYIGDDDEEEPEMPVGPR-----PRPLSDIHLKEKAVPMPEARAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFFYCTDSSKQTQAECRGSYIMYKDGDVGKPGRSPRVWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQTKNFNDAMNILNMLFTGLFTVEMILKLIAFKPRGYFSDPWNVFDFLIVIGSIIDVILSEINPADSSSSSSSSSSSSSSSTSHPPVVRPMGLQNSEENARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDL-SQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACS---PNRPCEKGSTNENSTASEE-CGSQFAIIYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTDGN-----LEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE-QGLVGKVPPKTA--LSLQA-----GL--RTLHD-IGPEIRRAISGDLNVEEEMDK 1726 HSP 2 Score: 98.5969 bits (244), Expect = 7.207e-20 Identity = 77/284 (27.11%), Postives = 133/284 (46.83%), Query Frame = 1
Query: 292 RSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIY 1143
R+ F N R+ +IV+ F LIL I + + L P + + N+IL + VF +FTIE LK+ +YG LH+ ++ RN +NILD +V + +++ + + + N +K LR RVLRPLR ++ L+ V+ + A++ + +I ++ L +++ IG++LF GK C ++ + + + + + D G SP + W D NFD+ M+ +F T EGW ++Y D+ IY
Sbjct: 904 RAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDP--VKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFF-YCTDS-SKQTQAECRGSYIMYKDGDVGKPGRSP----RVWENSD--------------FNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIY 1162
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Medaka
Match: cacna1c (voltage-dependent L-type calcium channel subunit alpha-1C [Source:NCBI gene;Acc:101173517]) HSP 1 Score: 1509.2 bits (3906), Expect = 0.000e+0 Identity = 876/1652 (53.03%), Postives = 1133/1652 (68.58%), Query Frame = 1
Query: 298 LFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT-------AISFNTKV---DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN-EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQN--------PEAAIE----------EMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND----------AKCKNNKSEEENAE--MVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVG--------------------------KTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKK 5049
L CL KNP+R IV+ KPFE++IL+TIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL A K D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TC +N T E P PC G G CT G C+ W GPNDGITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E + DD + + S+ ++N P +E ++KS+ + +R+ + R R+ + KS+ F+ L++ LVFLNT+ + +EHH+QP WL QDIAN V +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + A+ + K EEN + + + + ++ + + + G + + + CG ENE D + ++EEE G + PR ++K ++ +P AFF+FS TNKFRV CH +V H+ F N++L IL+SS+ LAAEDP++ S RN+IL Y D++FT +FTIEI LKM AYG LH G+FCRN FN+LDL+VV V+L+S I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+F+ C+DSSK T C+G +I YK P R WEN+ N+D+VL GM+ LF V+TFEGWPGLLY++ID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ +LIL NT+CLA + Q K + D ++ILN++FT +FT+E ILKL AF + YFSD WN+FDF++V+GS +D+I+S N + SS + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL + S I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C+ CE + ++ + CGS A YF+SFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR+++KK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK Q + +P TA S+Q GL RT + IG E + G N E+E K
Sbjct: 143 LLCLTLKNPIRRACISIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGATPIGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCVHNHTGLNAEEKPAPCAPD-GAYGRHCT-----QNGTQ--CRVG-----WEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGLDDDKPRNLSMPASENESVNTDNPPGGDVEGETCCTRLAIRISKSKFSRYSRRWNRLFRRKCRAAV---KSQVFYWLVIFLVFLNTLTIASEHHRQPQWLTDVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEAKERKKLARLASPKKHEENEKPPLEEKKSEKIELKSITSDGETNPATKISMDDCCG----------DENEEKNPYPANDYIGDDDEEEPEMPVGPR-----PRPLSDIHLKEKAVPMPEARAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFFYCTDSSKQTQAECRGSYIMYKDGDVGKPGRSPRVWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQTKNFNDAMNILNMLFTGLFTVEMILKLIAFKPRGYFSDPWNVFDFLIVIGSIIDVILSEINPADSSSSSSSSSSSSSSSTSHPPVVRPMGLQNSEENARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDL-SQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACS---PNRPCEKGSTNENSTASEE-CGSQFAIIYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTDGN-----LEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE-QGLVGKVPPKTA--LSLQA-----GL--RTLHD-IGPEIRRAISGDLNVEEEMDK 1735 HSP 2 Score: 98.5969 bits (244), Expect = 7.034e-20 Identity = 77/284 (27.11%), Postives = 133/284 (46.83%), Query Frame = 1
Query: 292 RSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIY 1143
R+ F N R+ +IV+ F LIL I + + L P + + N+IL + VF +FTIE LK+ +YG LH+ ++ RN +NILD +V + +++ + + + N +K LR RVLRPLR ++ L+ V+ + A++ + +I ++ L +++ IG++LF GK C ++ + + + + + D G SP + W D NFD+ M+ +F T EGW ++Y D+ IY
Sbjct: 913 RAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDP--VKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFF-YCTDS-SKQTQAECRGSYIMYKDGDVGKPGRSP----RVWENSD--------------FNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIY 1171
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Medaka
Match: cacna1c (voltage-dependent L-type calcium channel subunit alpha-1C [Source:NCBI gene;Acc:101173517]) HSP 1 Score: 1507.27 bits (3901), Expect = 0.000e+0 Identity = 876/1652 (53.03%), Postives = 1133/1652 (68.58%), Query Frame = 1
Query: 298 LFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT-------AISFNTKV---DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN-EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQN--------PEAAIE----------EMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND----------AKCKNNKSEEENAE--MVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVG--------------------------KTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKK 5049
L CL KNP+R IV+ KPFE++IL+TIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL A K D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TC +N T E P PC G G CT G C+ W GPNDGITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E + DD + + S+ ++N P +E ++KS+ + +R+ + R R+ + KS+ F+ L++ LVFLNT+ + +EHH+QP WL QDIAN V +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + A+ + K EEN + + + + ++ + + + G + + + CG ENE D + ++EEE G + PR ++K ++ +P AFF+FS TNKFRV CH +V H+ F N++L IL+SS+ LAAEDP++ S RN+IL Y D++FT +FTIEI LKM AYG LH G+FCRN FN+LDL+VV V+L+S I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+F+ C+DSSK T C+G +I YK P R WEN+ N+D+VL GM+ LF V+TFEGWPGLLY++ID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ +LIL NT+CLA + Q K + D ++ILN++FT +FT+E ILKL AF + YFSD WN+FDF++V+GS +D+I+S N + SS + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL + S I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C+ CE + ++ + CGS A YF+SFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR+++KK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK Q + +P TA S+Q GL RT + IG E + G N E+E K
Sbjct: 143 LLCLTLKNPIRRACISIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGATPIGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCVHNHTGLNAEEKPAPCAPD-GAYGRHCT-----QNGTQ--CRVG-----WEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGLDDDKPRNLSMPASENESVNTDNPPGGDVEGETCCTRLAIRISKSKFSRYSRRWNRLFRRKCRAAV---KSQVFYWLVIFLVFLNTLTIASEHHRQPQWLTDVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEAKERKKLARLASPKKHEENEKPPLEEKKSEKIELKSITSDGETNPATKISMDDCCG----------DENEEKNPYPANDYIGDDDEEEPEMPVGPR-----PRPLSDIHLKEKAVPMPEARAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFFYCTDSSKQTQAECRGSYIMYKDGDVGKPGRSPRVWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQTKNFNDAMNILNMLFTGLFTVEMILKLIAFKPRGYFSDPWNVFDFLIVIGSIIDVILSEINPADSSSSSSSSSSSSSSSTSHPPVVRPMGLQNSEENARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDL-SQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACS---PNRPCEKGSTNENSTASEE-CGSQFAIIYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTDGN-----LEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE-QGLVGKVPPKTA--LSLQA-----GL--RTLHD-IGPEIRRAISGDLNVEEEMDK 1735 HSP 2 Score: 98.2117 bits (243), Expect = 9.321e-20 Identity = 77/284 (27.11%), Postives = 133/284 (46.83%), Query Frame = 1
Query: 292 RSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIY 1143
R+ F N R+ +IV+ F LIL I + + L P + + N+IL + VF +FTIE LK+ +YG LH+ ++ RN +NILD +V + +++ + + + N +K LR RVLRPLR ++ L+ V+ + A++ + +I ++ L +++ IG++LF GK C ++ + + + + + D G SP + W D NFD+ M+ +F T EGW ++Y D+ IY
Sbjct: 913 RAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDP--VKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFF-YCTDS-SKQTQAECRGSYIMYKDGDVGKPGRSP----RVWENSD--------------FNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIY 1171
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Medaka
Match: cacna1c (voltage-dependent L-type calcium channel subunit alpha-1C [Source:NCBI gene;Acc:101173517]) HSP 1 Score: 1506.12 bits (3898), Expect = 0.000e+0 Identity = 876/1649 (53.12%), Postives = 1128/1649 (68.41%), Query Frame = 1
Query: 298 LFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILT-------AISFNTKV---DIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTN-EMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDE-ENDGNSDD------------------------YREISTSLDHNQ-----NPEAAIEE-----------MAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVND----------AKCKNNKSEEENAE--MVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHK-NIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKK 5049
L CL KNP+R IV+ KPFE++IL+TIFANCV L + P+P DSN+TN LE++E +F++IFT+EA LK+I+YG L H NAYLRN WN+LDF IV++G+ + IL A K D+K+LRAFRVLRPLRLVSG+PSLQ+VLNSII AM PL HIALLV F+++IY+IIG+ELFMGK+H TC +N T E P PC G G CT G C+ W GPNDGITNFDNF AMLTVFQ +TMEGWT V+YW+ DA GY+ PW+YFVSL++ GSFFVLNL+LGVLSGEFSKE+EK + FQK RE ++ +D GY +WI +A+++ E E +G DD + +S N+ NP E ++KS+ + +R+ + R R+ + KS+ F+ L++ LVFLNT+ + +EHH+QP WL QDIAN V +ALFT EM++K+ +LGL YF FN+FD F+V I+E L K+++P+G+SVLRC RLLR+FK+T+YWNSL +LV LL S++SI SLLLL+ LFI+IF+LLGMQ+FGGK+N D+ RS FD+F QS++TVFQILTGEDWN MY+GI ++GG + G LV +YF++LFI GNYILLNVFLAIAVDNL+D + + A+ + K EEN + + + + ++ + + + G + + + CG ENE D + ++EEE G + PR ++K ++ +P AFF+FS TNKFRV CH +V H+ F N++L IL+SS+ LAAEDP++ S RN+IL Y D++FT +FTIEI LKM AYG LH G+FCRN FN+LDL+VV V+L+S I ++ AI+ VKILRVLRVLRPLRAINRAKGLKHVVQCV VA+++IG I++VT LL FMFA + VQLFKG+F+ C+DSSK T C+G +I YK P R WEN+ N+D+VL GM+ LF V+TFEGWPGLLY++ID++ ED GP+YNY ++IF++ YIIIIAFFM+NIFVGFVIVTFQ++GE EYKNCEL KNQR+C+E+ALKARP +RY P+ +YK+W VV S FEY++ +LIL NT+CLA + Q K + D ++ILN++FT +FT+E ILKL AF ++YF DAWN FD ++V+GS VDI I+ N +S+ + ISI FFRLFRVMRLVKLLS+ + IR LLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIAL + S I+RNNNFQTFP AVL+LFR ATGE+WQEIML+C+ CE + ++ + CGS A YF+SFYM+C+FLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF WA+YD EAKGRI+HLDVVT+L +I PPLGFG +CPH AC +LV MNMPL +DGTV+FNATLFALVR L+IK ++Q NEELR+++KK+WKRTS +LLDQ++PP D VTVGKFYATFLIQ +FR +++RK Q + +P TA L L RT + IG E + G N E+E K
Sbjct: 165 LLCLTLKNPIRRACISIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGATPIGGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCVHNHTGLNAEEKPAPCAPD-GAYGRHCT-----QNGTQ--CRVG-----WEGPNDGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGLDDDKPRNRKNHHFLSLRGAVKKNAAFLRKALSMPASENESVNTDNPPGGDVEGETCCTRLAIRISKSKFSRYSRRWNRLFRRKCRAAV---KSQVFYWLVIFLVFLNTLTIASEHHRQPQWLTDVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEAKERKKLARLASPKKHEENEKPPLEEKKSEKIELKSITSDGETNPATKISMDDCCG----------DENEEKNPYPANDYIGDDDEEEPEMPVGPR-----PRPLSDIHLKEKAVPMPEARAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGI-------QSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFFYCTDSSKQTQAECRGSYIMYKDGDVGKPGRSPRVWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIYNYRVVISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQTKNFNDAMNILNMLFTGLFTVEMILKLIAFKPRHYFVDAWNTFDALIVVGSIVDIAITEVNGLQNSE--ENARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALRDL-SQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACS---PNRPCEKGSTNENSTASEE-CGSQFAIIYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTDGN-----LEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKE-QGLVGKVPPKTA---------LSLQAGLRTLHD-IGPEIRRAISGDLNVEEEMDK 1752 HSP 2 Score: 98.9821 bits (245), Expect = 5.905e-20 Identity = 77/284 (27.11%), Postives = 133/284 (46.83%), Query Frame = 1
Query: 292 RSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIY 1143
R+ F N R+ +IV+ F LIL I + + L P + + N+IL + VF +FTIE LK+ +YG LH+ ++ RN +NILD +V + +++ + + + N +K LR RVLRPLR ++ L+ V+ + A++ + +I ++ L +++ IG++LF GK C ++ + + + + + D G SP + W D NFD+ M+ +F T EGW ++Y D+ IY
Sbjct: 958 RAFFVFSHTNKFRVLCHKIVNHNIFTNLILFFILLSSISLAAEDP--VKNDSFRNQILGYADHVFTGLFTIEIILKMTAYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSAINV---VKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKFF-YCTDS-SKQTQAECRGSYIMYKDGDVGKPGRSP----RVWENSD--------------FNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHSEDVGPIY 1216
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Planmine SMEST
Match: SMESG000015876.1 (SMESG000015876.1) HSP 1 Score: 3760.69 bits (9751), Expect = 0.000e+0 Identity = 1963/1970 (99.64%), Postives = 1967/1970 (99.85%), Query Frame = 1
Query: 109 MTSTGSTLYTASSQNPWKXXXXXXXXXXXXNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLKPDSPTFTDDKSEIFDYFIRVPTADSLYHNSRPSQVSTNSISLYDGRRIGQRVVGSTSNRNNSQGPSLASTHLEISREPISDIXXXXXXXXXXXXXXXXHNRFRKLSSIGERISSFWTRLNTHAPSLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPRSVRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPETSNNYRKSYPVEDIGNEHSRHYLGSPLSYSEDEVKMAREMFAAARKESLKPNI 6018
MTSTGSTLYTASSQNPWKSGAGGGSAFGTGNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCL KKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDDDEEEEVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYDEMDVEEEEEFLNEDGKKV SACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTIDMVKAYKRNEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIISRTNISSSSQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIPEPSTTESSEHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELR+VIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLK DSPTFTDDKSEIFDYFIRVPTADSLYHNSRPSQVSTNSISLYDGRRIGQRVVGSTSNRNNSQGPSLASTHLEISREPISDIESNSPEGEPSPSDSYSHNRFRKLSSIGERISSFWTRLNTHAPSLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPR+VRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPET+NNYRKSYPVEDIGNEHSR+YLGSPLSYSEDEVKMAREMFAAARKESLKPNI
Sbjct: 1 MTSTGSTLYTASSQNPWKSGAGGGSAFGTGNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLAKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDDDEEEEVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYDEMDVEEEEEFLNEDGKKVGSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTIDMVKAYKRNEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIISRTNISSSSQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIPEPSTTESSEHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRAVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLKADSPTFTDDKSEIFDYFIRVPTADSLYHNSRPSQVSTNSISLYDGRRIGQRVVGSTSNRNNSQGPSLASTHLEISREPISDIESNSPEGEPSPSDSYSHNRFRKLSSIGERISSFWTRLNTHAPSLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPRAVRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPETANNYRKSYPVEDIGNEHSRNYLGSPLSYSEDEVKMAREMFAAARKESLKPNI 1970
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Planmine SMEST
Match: SMESG000015876.1 (SMESG000015876.1) HSP 1 Score: 3736.81 bits (9689), Expect = 0.000e+0 Identity = 1955/1970 (99.24%), Postives = 1960/1970 (99.49%), Query Frame = 1
Query: 109 MTSTGSTLYTASSQNPWKXXXXXXXXXXXXNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLKPDSPTFTDDKSEIFDYFIRVPTADSLYHNSRPSQVSTNSISLYDGRRIGQRVVGSTSNRNNSQGPSLASTHLEISREPISDIXXXXXXXXXXXXXXXXHNRFRKLSSIGERISSFWTRLNTHAPSLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPRSVRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPETSNNYRKSYPVEDIGNEHSRHYLGSPLSYSEDEVKMAREMFAAARKESLKPNI 6018
MTSTGSTLYTASSQNPWKSGAGGGSAFGTGNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCL KKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDDDEEEEVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYDEMDVEEEEEFLNEDGKKV SACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTI+ NEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIISRTNISSSSQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIPEPSTTESSEHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELR+VIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLK DSPTFTDDKSEIFDYFIRVPTADSLYHNSRPSQVSTNSISLYDGRRIGQRVVGSTSNRNNSQGPSLASTHLEISREPISDIESNSPEGEPSPSDSYSHNRFRKLSSIGERISSFWTRLNTHAPSLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPR+VRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPET+NNYRKSYPVEDIGNEHSR+YLGSPLSYSEDEVKMAREMFAAARKESLKPNI
Sbjct: 1 MTSTGSTLYTASSQNPWKSGAGGGSAFGTGNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLAKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDDDEEEEVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYDEMDVEEEEEFLNEDGKKVGSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTIE-------NEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIISRTNISSSSQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIPEPSTTESSEHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRAVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLKADSPTFTDDKSEIFDYFIRVPTADSLYHNSRPSQVSTNSISLYDGRRIGQRVVGSTSNRNNSQGPSLASTHLEISREPISDIESNSPEGEPSPSDSYSHNRFRKLSSIGERISSFWTRLNTHAPSLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPRAVRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPETANNYRKSYPVEDIGNEHSRNYLGSPLSYSEDEVKMAREMFAAARKESLKPNI 1963
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Planmine SMEST
Match: SMESG000015876.1 (SMESG000015876.1) HSP 1 Score: 3708.69 bits (9616), Expect = 0.000e+0 Identity = 1955/2017 (96.93%), Postives = 1960/2017 (97.17%), Query Frame = 1
Query: 109 MTSTGSTLYTASSQNPWKXXXXXXXXXXXXNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFL-----------------------------------------------IINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLKPDSPTFTDDKSEIFDYFIRVPTADSLYHNSRPSQVSTNSISLYDGRRIGQRVVGSTSNRNNSQGPSLASTHLEISREPISDIXXXXXXXXXXXXXXXXHNRFRKLSSIGERISSFWTRLNTHAPSLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPRSVRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPETSNNYRKSYPVEDIGNEHSRHYLGSPLSYSEDEVKMAREMFAAARKESLKPNI 6018
MTSTGSTLYTASSQNPWKSGAGGGSAFGTGNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCL KKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDDDEEEEVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYDEMDVEEEEEFLNEDGKKV SACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTI+ NEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIISRTNISSSSQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIPEPSTTESSEHDFCGSWVAYPYFISFYMICSFL IINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELR+VIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLK DSPTFTDDKSEIFDYFIRVPTADSLYHNSRPSQVSTNSISLYDGRRIGQRVVGSTSNRNNSQGPSLASTHLEISREPISDIESNSPEGEPSPSDSYSHNRFRKLSSIGERISSFWTRLNTHAPSLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPR+VRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPET+NNYRKSYPVEDIGNEHSR+YLGSPLSYSEDEVKMAREMFAAARKESLKPNI
Sbjct: 1 MTSTGSTLYTASSQNPWKSGAGGGSAFGTGNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLAKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDDDEEEEVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYDEMDVEEEEEFLNEDGKKVGSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTIE-------NEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIISRTNISSSSQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIPEPSTTESSEHDFCGSWVAYPYFISFYMICSFLKILIFPSAEKSQCDPASDPAENDKNHKCGSIVTYPFFISFYVICCFVIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRAVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTGSRLKADSPTFTDDKSEIFDYFIRVPTADSLYHNSRPSQVSTNSISLYDGRRIGQRVVGSTSNRNNSQGPSLASTHLEISREPISDIESNSPEGEPSPSDSYSHNRFRKLSSIGERISSFWTRLNTHAPSLDASNCNFNNNQYSVSHQLEPHSERIDFKYGDLVGDDPHANTGIMSMLPRAVRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPETANNYRKSYPVEDIGNEHSRNYLGSPLSYSEDEVKMAREMFAAARKESLKPNI 2010
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Planmine SMEST
Match: SMESG000015876.1 (SMESG000015876.1) HSP 1 Score: 3216.79 bits (8339), Expect = 0.000e+0 Identity = 1688/1699 (99.35%), Postives = 1690/1699 (99.47%), Query Frame = 1
Query: 109 MTSTGSTLYTASSQNPWKXXXXXXXXXXXXNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIXXXXXXXXXXHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTG 5205
MTSTGSTLYTASSQNPWKSGAGGGSAFGTGNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCL KKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDDDEEEEVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYDEMDVEEEEEFLNEDGKKV SACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTI+ NEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIISRTNISSSSQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIPEPSTTESSEHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELR+VIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTG
Sbjct: 1 MTSTGSTLYTASSQNPWKSGAGGGSAFGTGNRPFIADLALAALKDREGAKHRQLCSSLKPDRSLFCLAKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDNNLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSDEENDGNSDDYREISTSLDHNQNPEAAIEEMAKSRCHKILKRFRKTRNRWRRSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKSRSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSDDDDEEEEVNDAKCKNNKSEEENAEMVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYDEMDVEEEEEFLNEDGKKVGSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNLLDLLVVFVALVSFTIE-------NEAISAVKILRVLRVLRPLRAINRAKGLKHVVQCVVVAVKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSVENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYIIIIAFFMINIFVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDIIISRTNISSSSQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDSSISRNNNFQTFPAAVLVLFRSATGESWQEIMLSCTGTDEKSRCEIPEPSTTESSEHDFCGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRAVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDWQRRKMIQKDIRYIPQITAGDRSMQGQPLILGLPRRTSSELIGDEFKARKKGTQNDEKETKKDFSLSTKRLITPPSNQAISNPVLQSSLPNGGIQFQNLAQKSDSKPNDNKSTG 1692 HSP 2 Score: 256.144 bits (653), Expect = 4.028e-68 Identity = 119/123 (96.75%), Postives = 122/123 (99.19%), Query Frame = 1
Query: 5650 EPHSERIDFKYGDLVGDDPHANTGIMSMLPRSVRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPETSNNYRKSYPVEDIGNEHSRHYLGSPLSYSEDEVKMAREMFAAARKESLKPNI 6018
PHSERIDFKYGDLVGDDPHANTGIMSMLPR+VRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPET+NNYRKSYPVEDIGNEHSR+YLGSPLSYSEDEVKMAREMFAAARKESLKPNI
Sbjct: 1693 RPHSERIDFKYGDLVGDDPHANTGIMSMLPRAVRISTTSMGMSANHEIKTPIVFMQNQALAMAGMPIKPETANNYRKSYPVEDIGNEHSRNYLGSPLSYSEDEVKMAREMFAAARKESLKPNI 1815
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Planmine SMEST
Match: SMESG000000524.1 (SMESG000000524.1) HSP 1 Score: 1636.7 bits (4237), Expect = 0.000e+0 Identity = 933/1654 (56.41%), Postives = 1162/1654 (70.25%), Query Frame = 1
Query: 223 ALAALKDREGAKHRQLCSSLKPDRSLFCLEKKNPVRIFIARIVDSKPFEVLILLTIFANCVVLGMNRPYPAGDSNSTNRILEKLEVVFVVIFTIEASLKIISYGFLLHQNAYLRNAWNILDFFIVIIGVVTEILTAISFNTKVDIKSLRAFRVLRPLRLVSGLPSLQIVLNSIITAMKPLFHIALLVFFLVVIYSIIGMELFMGKLHATCYNNVTNEMMEDPKPCMVGLGDDGYSCTGLSPLDEGQSWICKDN-NLTERWVGPNDGITNFDNFGLAMLTVFQAMTMEGWTQVMYWINDAQGYKWPWIYFVSLILLGSFFVLNLILGVLSGEFSKEKEKIDRKEQFQKEREAKRQNQDYLGYKEWIEKADELSD-EENDG--------------------NSDDYREISTSLD--------HNQNPEAAIEEMAKSRCHKILKXXXXXXXXXXXSVIIYMKSKQFFILILSLVFLNTMVLCTEHHKQPLWLDSFQDIANIVFVALFTFEMVIKILALGLGEYFSKAFNKFDLFIVLCSIIELSLTRPKVINPIGLSVLRCARLLRVFKLTQYWNSLRSLVEKLLKSMKSIFSLLLLMGLFIVIFALLGMQMFGGKYNLDKKS--RSNFDHFWQSVITVFQILTGEDWNEEMYNGIRSFGGVNGLGALVSLYFVVLFIVGNYILLNVFLAIAVDNLSXXXXXXXXV----------------NDAKCKNNKSEEENAE---MVDNQDGMVKDEKLANGGVGDACSITNHPSTCGLTTKDMIRKHFENEHSQEKRGYXXXXXXXXXXXXXXXGKKVDSACPRRNDVDNMKTESQKIPPYSAFFIFSDTNKFRVFCHNVVCHSYFGNIVLVCILVSSVMLAAEDPIRTSSRRNKILNYFDYIFTTVFTIEITLKMIAYGFLLHPGAFCRNTFNXXXXXXXXXXXXSFTIDMVKAYKRNEAISAVKIXXXXXXXXXXXAINRAKGLKHXXXXXXXXXKSIGKIMLVTFLLVFMFAVMAVQLFKGRFYSCSDSSKLTNETCKGQFINYKSHKNIPSV--ENRTWENNPLNYDNVLSGMLTLFVVATFEGWPGLLYKSIDAYKEDYGPVYNYNQGVAIFYVTYXXXXXXXXXXXXVGFVIVTFQKEGESEYKNCELSKNQRKCIEFALKARPRKRYTPQGHLRYKMWSVVCSKKFEYVILSLILANTLCLAARFDQQPKFYTDTLDILNIIFTVVFTLEFILKLSAFSFKNYFSDAWNIFDFIVVLGSYVDXXXXXXXXXXXXQVGKTKFISINFFRLFRVMRLVKLLSKEDSIRKLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALNNTDS--SISRNNNFQTFPAAVLVLFRSATGESWQEIMLS------CTGTDEKSRCEIXXXXXXXXXX---------------HDF-----------------CGSWVAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFITRWADYDIEAKGRIRHLDVVTMLGKISPPLGFGNMCPHTRACHKLVRMNMPLQADGTVLFNATLFALVRRNLKIKIPAEDDKKPMDQWNEELRSVIKKVWKRTSPQLLDQIIPPKDSDTVTVGKFYATFLIQNWFRDW-QRRKMIQKDIRY 4902
A A R+ R + +P R+LFCL +NP R F +IV+ KPFE LIL TIFANC L N PYP DSN+ N LEK+E+VF+VIFT E LKI+++GF++H AYLRN WN+LDF IVIIG+++ +L+ +S D+K+LRAFRVLRPLRLVSGLPSLQ+V+NSI+ AM PLFHIALL F+++IY+IIG+ELF GKLH+TCY+ + MME P PC + + GY C G ++CKDN N T RW GPN GIT+FDNFGLAMLTVFQ +TMEGWTQ+MYWIND+ G WPWIYFVSLI++GSFFV+NL+LGVLSGEFSKE+EK ++ ++QK RE + ++D GY +WI A+++SD EENDG + D ++S LD H+Q + KSR + K R RR +KS+ F+ +++ LVFLNT VL +EH++Q +WLDSFQ+ ANI+FV LFT EM+IK+ +LG+ YF FN+FD F+V+ SI+E+ + + + P+G+SVLRCARLLRVFK+T+YW+SLR+LV LL SMKSI SLL+L+ LFIVIF+LLGMQ+FGGK+N DKK+ RSNFD F QS++TVFQILTGEDWNE MY+GIRS+G + L LY+V+LFI GNYILLNVFLAIAVDNL+D +E +AK N+ + N + + + ++K E++ NG + D ST T K+ ++ E + E+ G ++ RR K + + IP S+FFIF NKFR FCH + H +FGNIVLVCI+VSS MLAAEDP+ S RN+ILNYFDY+FT+VFT+EITLK+I YG + H GAFCR++ N+LDLLVV +++S+ I+ N+AIS VKILRVLRVLRPLRAINRAKGLK VVQCVVVAVKSIG IMLVTFLL FMFAV+ VQLF G+F SC+D SK T+ +C+GQ+I Y + +I V R W NNPLN+DNV + MLTLF V+TFEGWPG+LYKSID++KEDY +YN V+IFY+ YII+IAFFMINIFVGFVIVTFQ+EGE EYKNCEL KNQRKCIEFALKA+P +RY P+ RY++W ++ S+ FEY+I LI+ NT+ LA +FD+QP+ Y +D LN++FT VFT+EF+LKL+AF FKNYFSDAWN+FDFI+VLGS++DII N ++++ G + ISINFFRLFRVMRLVKLLS+ + IR LLWTF+KSFQALPYVALLIVMLFFIYAVIGMQMFGKI N I+RNNNFQTFP A+LVLFRSATGE+WQ IML C ++ R E + + + H+F CGS AYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF+ W++YD EAKGRI+HLDVVT+L KI+PPLGFG CPH AC LVRMNMPL +DGTV+FNATLFALVR NLKIK D +DQ NEELR VIKK+WKRTS ++LDQ++PP +D VTVGKFYATFLIQ WFR W Q+R QK + Y
Sbjct: 71 AQIASGGRKRTPARSQSGNPRPQRALFCLTLRNPFRKFCIKIVEWKPFEYLILFTIFANCCALAANTPYPERDSNTINSALEKIELVFIVIFTTECVLKILAFGFIMHPGAYLRNGWNLLDFLIVIIGLISTVLSKMS-EGGPDVKALRAFRVLRPLRLVSGLPSLQVVMNSIMRAMVPLFHIALLALFVIIIYAIIGLELFSGKLHSTCYSK-NDVMMESPVPCSTSV-NKGYQCDDFH--SSGFKYMCKDNKNETSRWSGPNMGITSFDNFGLAMLTVFQCITMEGWTQIMYWINDSVGMSWPWIYFVSLIIIGSFFVMNLVLGVLSGEFSKEREKAKKRGKYQKAREQMQFDEDVQGYLDWIGAAEDISDDEENDGKENGKESRFKLCGLCKSSEKSDDGDDQLSDKLDLETEGGAHHSQQQQYVFCFPLKSRRGR------KWNRRCRRICRRLVKSQAFYWVVIVLVFLNTGVLTSEHYRQSIWLDSFQNTANIIFVVLFTLEMLIKMYSLGMRCYFDFMFNRFDFFVVIFSILEIVMIQTDAMPPLGVSVLRCARLLRVFKVTRYWSSLRNLVGSLLASMKSIVSLLVLLFLFIVIFSLLGMQLFGGKFNFDKKAKPRSNFDSFVQSLLTVFQILTGEDWNEVMYDGIRSYGNLGKSSMLSCLYYVILFICGNYILLNVFLAIAVDNLADTGSGNKEEKKEGENEEGEPTNVDGEEAKACNSSNVSPNIDEKTRFTDAERLIKSEEM-NGDIADES--MRKMSTRIDTEKENDEEYAEGDEEDEENG--------------------QTSAIRRVSEVMAKEKIKPIPNASSFFIFGPNNKFRKFCHFICNHPHFGNIVLVCIMVSSAMLAAEDPLDAESSRNRILNYFDYLFTSVFTVEITLKVITYGLVFHNGAFCRSSNNILDLLVVLTSIISYPIN-------NDAISVVKILRVLRVLRPLRAINRAKGLKRVVQCVVVAVKSIGNIMLVTFLLEFMFAVIGVQLFNGKFQSCNDVSKNTHISCRGQYI-YYNEADIAKVFVNKREWINNPLNFDNVPNAMLTLFAVSTFEGWPGVLYKSIDSFKEDYSGIYNNRPIVSIFYIAYIIVIAFFMINIFVGFVIVTFQQEGEEEYKNCELDKNQRKCIEFALKAKPVRRYIPKQSFRYRVWWLITSRPFEYIIFVLIMLNTISLALKFDKQPQRYEQVMDYLNMVFTGVFTVEFLLKLAAFGFKNYFSDAWNVFDFIIVLGSFIDIIYDHVNGTNNNHRGD-RLISINFFRLFRVMRLVKLLSRGEGIRTLLWTFVKSFQALPYVALLIVMLFFIYAVIGMQMFGKITTENEKEMKEINRNNNFQTFPQAILVLFRSATGEAWQNIMLHCLPDAMCDALSDQIRKEYYNLTVMRARQAGNLGFNDSMVIWPPHNFVKVKINKYISHYQDVAKCGSNFAYPYFISFYMICSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFVRLWSEYDPEAKGRIKHLDVVTLLRKINPPLGFGKYCPHRTACVTLVRMNMPLNSDGTVMFNATLFALVRTNLKIKT----DGSTVDQLNEELRVVIKKIWKRTSQKMLDQVVPPAGNDDVTVGKFYATFLIQEWFRRWKQKRNEEQKGMAY 1677 The following BLAST results are available for this feature:
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Voltage-dependent L-type calcium channel subunit alpha vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30030253 ID=SMED30030253|Name=Voltage-dependent L-type calcium channel subunit alpha|organism=Schmidtea mediterranea sexual|type=transcript|length=6367bpback to top protein sequence of SMED30030253-orf-1 >SMED30030253-orf-1 ID=SMED30030253-orf-1|Name=SMED30030253-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1971bp MTSTGSTLYTASSQNPWKSGAGGGSAFGTGNRPFIADLALAALKDREGAKback to top protein sequence of SMED30030253-orf-2 >SMED30030253-orf-2 ID=SMED30030253-orf-2|Name=SMED30030253-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=116bp IYYSNNRFCKFIIIIVIIVIIFLKTNLNQLKALKHVNYLYQRNTKKRSNGback to top Annotated Terms
The following terms have been associated with this transcript:
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