Histidine triad nucleotide-binding protein 1
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30030230 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT2 (histidine triad nucleotide binding protein 2 [Source:HGNC Symbol;Acc:HGNC:18344]) HSP 1 Score: 176.022 bits (445), Expect = 2.750e-56 Identity = 78/132 (59.09%), Postives = 103/132 (78.03%), Query Frame = 1 Query: 70 VRSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 V +EV KA+ A G TIF +I++K++PADILYED+ CL FRDV+PQAP+HFLVIPKK I + AE+ D+QLLGHL+++AK+ AK E L +GYR+VIN+G GAQSV+HLH+H++GGRQ+ WPPG Sbjct: 34 VTDGNEVAKAQQATPGGAAP--TIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG 163
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4912]) HSP 1 Score: 168.703 bits (426), Expect = 6.682e-54 Identity = 78/127 (61.42%), Postives = 95/127 (74.80%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 E+ KA+ A GD TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ + AED DE LLGHLMI+ K+ A L+ GYR+V+N GSDG QSV+H+HLH++GGRQM WPPG Sbjct: 4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4912]) HSP 1 Score: 88.5817 bits (218), Expect = 4.814e-23 Identity = 45/79 (56.96%), Postives = 55/79 (69.62%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLM 321 E+ KA+ A GD TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ + AED DE + +LM Sbjct: 4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESSVEYLM 78
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4912]) HSP 1 Score: 85.5001 bits (210), Expect = 8.715e-22 Identity = 43/74 (58.11%), Postives = 52/74 (70.27%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQL 306 E+ KA+ A GD TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ + AED DE + Sbjct: 4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESV 73
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4912]) HSP 1 Score: 86.2705 bits (212), Expect = 8.818e-22 Identity = 43/75 (57.33%), Postives = 53/75 (70.67%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLL 309 E+ KA+ A GD TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ + AED DE ++ Sbjct: 4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESVI 74
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Celegans
Match: hint-1 (Histidine triad nucleotide-binding protein 1 [Source:UniProtKB/Swiss-Prot;Acc:P53795]) HSP 1 Score: 181.03 bits (458), Expect = 4.523e-59 Identity = 84/130 (64.62%), Postives = 103/130 (79.23%), Query Frame = 1 Query: 79 MSEVDKAKAACDSGD-KTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 MSEVDKA A + D + T+F KII K IPA I++ED+ LAF DVSPQAPIHFLVIPK+RI ML++A DSD L+G LM+ A +VAKQ ++NGYR+V+NNG DGAQSVFHLHLH++GGRQ+ WPPG Sbjct: 1 MSEVDKAHLAAINKDVQANDTLFGKIIRKEIPAKIIFEDDEALAFHDVSPQAPIHFLVIPKRRIDMLENAVDSDAALIGKLMVTASKVAKQLGMANGYRVVVNNGKDGAQSVFHLHLHVLGGRQLQWPPG 130
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Celegans
Match: hint-1 (Histidine triad nucleotide-binding protein 1 [Source:UniProtKB/Swiss-Prot;Acc:P53795]) HSP 1 Score: 181.03 bits (458), Expect = 4.523e-59 Identity = 84/130 (64.62%), Postives = 103/130 (79.23%), Query Frame = 1 Query: 79 MSEVDKAKAACDSGD-KTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 MSEVDKA A + D + T+F KII K IPA I++ED+ LAF DVSPQAPIHFLVIPK+RI ML++A DSD L+G LM+ A +VAKQ ++NGYR+V+NNG DGAQSVFHLHLH++GGRQ+ WPPG Sbjct: 1 MSEVDKAHLAAINKDVQANDTLFGKIIRKEIPAKIIFEDDEALAFHDVSPQAPIHFLVIPKRRIDMLENAVDSDAALIGKLMVTASKVAKQLGMANGYRVVVNNGKDGAQSVFHLHLHVLGGRQLQWPPG 130
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Celegans
Match: nft-1 (Nitrilase and fragile histidine triad fusion protein NitFhit Bis(5'-adenosyl)-triphosphatase Nitrilase homolog [Source:UniProtKB/Swiss-Prot;Acc:O76463]) HSP 1 Score: 50.0618 bits (118), Expect = 2.091e-7 Identity = 39/116 (33.62%), Postives = 57/116 (49.14%), Query Frame = 1 Query: 121 DKTRHTIFDKIINKTIPAD-ILYEDESCLAFRDVSPQAPIHFLVIPKK---RITMLDSAEDSDEQLLGHLMIIAKRVA----KQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGR 444 +K+ T K IPAD I Y F ++ P H LV PK+ R+T L AE +D L I+AK+V K N+++ I + +G D Q+V H+H+HI+ R Sbjct: 291 EKSSETGGLKFARFNIPADHIFYSTPHSFVFVNLKPVTDGHVLVSPKRVVPRLTDLTDAETAD------LFIVAKKVQAMLEKHHNVTST-TICVQDGKDAGQTVPHVHIHILPRR 399
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Fly
Match: CG2862 (gene:FBgn0031459 transcript:FBtr0335128) HSP 1 Score: 167.933 bits (424), Expect = 1.302e-53 Identity = 77/131 (58.78%), Postives = 97/131 (74.05%), Query Frame = 1 Query: 73 RSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 R SEV+K++ A S D TIF KI+ K IP ++ED+ C+AF DV+PQAP HFLVIP+K I L AED D LLGHLM++ ++VAK+ L++GYR+VINNG GAQSV+HLHLH +GGRQM WPPG Sbjct: 24 RMASEVEKSQTAAASED----TIFGKILRKEIPCKFIHEDDKCVAFHDVAPQAPTHFLVIPRKPIAQLSLAEDGDADLLGHLMLVGRKVAKELGLADGYRVVINNGKHGAQSVYHLHLHFLGGRQMQWPPG 150
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Fly
Match: CG2862 (gene:FBgn0031459 transcript:FBtr0077718) HSP 1 Score: 167.933 bits (424), Expect = 1.302e-53 Identity = 77/131 (58.78%), Postives = 97/131 (74.05%), Query Frame = 1 Query: 73 RSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 R SEV+K++ A S D TIF KI+ K IP ++ED+ C+AF DV+PQAP HFLVIP+K I L AED D LLGHLM++ ++VAK+ L++GYR+VINNG GAQSV+HLHLH +GGRQM WPPG Sbjct: 24 RMASEVEKSQTAAASED----TIFGKILRKEIPCKFIHEDDKCVAFHDVAPQAPTHFLVIPRKPIAQLSLAEDGDADLLGHLMLVGRKVAKELGLADGYRVVINNGKHGAQSVYHLHLHFLGGRQMQWPPG 150
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Fly
Match: CG2862 (gene:FBgn0031459 transcript:FBtr0077719) HSP 1 Score: 166.007 bits (419), Expect = 3.110e-53 Identity = 76/128 (59.38%), Postives = 96/128 (75.00%), Query Frame = 1 Query: 82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 SEV+K++ A S D TIF KI+ K IP ++ED+ C+AF DV+PQAP HFLVIP+K I L AED D LLGHLM++ ++VAK+ L++GYR+VINNG GAQSV+HLHLH +GGRQM WPPG Sbjct: 3 SEVEKSQTAAASED----TIFGKILRKEIPCKFIHEDDKCVAFHDVAPQAPTHFLVIPRKPIAQLSLAEDGDADLLGHLMLVGRKVAKELGLADGYRVVINNGKHGAQSVYHLHLHFLGGRQMQWPPG 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: hint1 (histidine triad nucleotide binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-040927-8]) HSP 1 Score: 168.318 bits (425), Expect = 6.654e-54 Identity = 72/127 (56.69%), Postives = 100/127 (78.74%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 EV +A++A GD TIF KII K IPA+I+YED+ C+AF DV+PQAP HFLV+P+K I+ + ED+D++LLGH+MI+AK+ A+Q L GYR+V+N+G DG QSV+H+H+H++GGRQ+ WPPG Sbjct: 4 EVSRAQSAQPGGD----TIFGKIIRKEIPANIIYEDDQCIAFNDVAPQAPTHFLVVPRKPISQISKVEDADKELLGHMMIVAKKCAEQVGLPRGYRLVVNDGPDGGQSVYHIHIHVLGGRQLGWPPG 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: hint1 (histidine triad nucleotide binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-040927-8]) HSP 1 Score: 168.318 bits (425), Expect = 6.654e-54 Identity = 72/127 (56.69%), Postives = 100/127 (78.74%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 EV +A++A GD TIF KII K IPA+I+YED+ C+AF DV+PQAP HFLV+P+K I+ + ED+D++LLGH+MI+AK+ A+Q L GYR+V+N+G DG QSV+H+H+H++GGRQ+ WPPG Sbjct: 4 EVSRAQSAQPGGD----TIFGKIIRKEIPANIIYEDDQCIAFNDVAPQAPTHFLVVPRKPISQISKVEDADKELLGHMMIVAKKCAEQVGLPRGYRLVVNDGPDGGQSVYHIHIHVLGGRQLGWPPG 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: hint2 (histidine triad nucleotide binding protein 2 [Source:ZFIN;Acc:ZDB-GENE-070410-139]) HSP 1 Score: 169.088 bits (427), Expect = 7.938e-54 Identity = 74/127 (58.27%), Postives = 98/127 (77.17%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 EV A+ A K TIF KII+KT+PA I+YED+ CLAFRDV+PQAP+H+LVIP+ I + A D D +LGHL+++AK +AK+E L+ GYR+VIN+G +GAQSV+HLH+H++GGRQM WPPG Sbjct: 35 EVRLAQEASKKYGKLEPTIFTKIIDKTVPAVIIYEDDKCLAFRDVNPQAPVHYLVIPRIPIPRISEAHDEDSLILGHLLVVAKNIAKKEGLAEGYRVVINDGKNGAQSVYHLHIHVLGGRQMKWPPG 161
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: si:dkey-25e12.3 (si:dkey-25e12.3 [Source:NCBI gene;Acc:678527]) HSP 1 Score: 55.8398 bits (133), Expect = 8.043e-10 Identity = 32/89 (35.96%), Postives = 48/89 (53.93%), Query Frame = 1 Query: 172 ADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438 +IL EDE + FRD++P AP H+LVIPKK I S D L+ + + + V K N+++ I + +V HLHLH++ Sbjct: 36 TEILAEDEDFVCFRDINPGAPHHYLVIPKKHIYSCLSLYADDISLVRGMAEMGRNVLKANNVTDLKDISLGFHVPPYITVPHLHLHVLA 124
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: si:dkey-25e12.3 (si:dkey-25e12.3 [Source:NCBI gene;Acc:678527]) HSP 1 Score: 55.4546 bits (132), Expect = 9.098e-10 Identity = 32/89 (35.96%), Postives = 48/89 (53.93%), Query Frame = 1 Query: 172 ADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438 +IL EDE + FRD++P AP H+LVIPKK I S D L+ + + + V K N+++ I + +V HLHLH++ Sbjct: 36 TEILAEDEDFVCFRDINPGAPHHYLVIPKKHIYSCLSLYADDISLVRGMAEMGRNVLKANNVTDLKDISLGFHVPPYITVPHLHLHVLA 124
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Xenopus
Match: hint1 (histidine triad nucleotide binding protein 1 [Source:NCBI gene;Acc:548919]) HSP 1 Score: 173.711 bits (439), Expect = 5.560e-56 Identity = 77/127 (60.63%), Postives = 95/127 (74.80%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 E+ KA+ AC GD TIF KII K IPA I+YEDE C+AF D++PQAP+HFLV+PKK IT L A+ +DE+LLGHLMI+ + A L+NGYR+ +N G DG QSV+HLHLH+ GGRQM WPPG Sbjct: 4 EISKAQTACPGGD----TIFGKIIRKEIPAKIIYEDEQCIAFHDIAPQAPVHFLVVPKKFITHLSKADPADEKLLGHLMIVGSKCAADLGLTNGYRLAVNEGPDGGQSVYHLHLHVFGGRQMGWPPG 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Xenopus
Match: sirt3.2 (sirtuin (silent mating type information regulation 2 homolog) 3, gene 2 [Source:Xenbase;Acc:XB-GENE-5721494]) HSP 1 Score: 105.916 bits (263), Expect = 1.752e-28 Identity = 53/113 (46.90%), Postives = 73/113 (64.60%), Query Frame = 1 Query: 85 EVDKAKAAC---DSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDE-------------QLLGHLMIIAKRVAKQENLSNGYRI 375 EV KA+ A + G + TIF +II++T+PADI++ED+ C+AFRDV+PQAP+HFLVIPK I L SD QLLGHL++ A R+A +E L++GYR+ Sbjct: 59 EVQKAQRAAAERNGGSPSPPTIFSRIIDRTLPADIIHEDDKCVAFRDVNPQAPVHFLVIPKTPIARLSQVNASDTELQTNWLHVCFSLQLLGHLLVTASRLAHKEGLADGYRL 171
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Xenopus
Match: cks2 (CDC28 protein kinase regulatory subunit 2 [Source:Xenbase;Acc:XB-GENE-922081]) HSP 1 Score: 52.7582 bits (125), Expect = 1.420e-8 Identity = 29/101 (28.71%), Postives = 53/101 (52.48%), Query Frame = 1 Query: 139 IFDKIINKTIP-ADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438 IF +I NK A++L+ D+ + F+D+ P H+LV+PKK + + QL+ +M + K ++ N+++ I + S+ HLHLH++ Sbjct: 20 IFCRIANKQESGAELLHSDDDLVCFKDIRPAVTHHYLVVPKKHVGTCKTLTKDHVQLIKTMMEVGKSTLQKNNVTDLEDIRLGFHYPPFCSISHLHLHVLA 120
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Mouse
Match: Hint2 (histidine triad nucleotide binding protein 2 [Source:MGI Symbol;Acc:MGI:1916167]) HSP 1 Score: 174.096 bits (440), Expect = 9.822e-56 Identity = 73/128 (57.03%), Postives = 103/128 (80.47%), Query Frame = 1 Query: 82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 SEV KA+ A G TIF +I+++++PADILYED+ CL FRDV+PQAP+HFLVIP+K I + AE+ D+QLLGHL+++AK++A+ + L +GYR+V+N+G GAQSV+HLH+H++GGRQ+ WPPG Sbjct: 38 SEVAKAQKAAPGGASP--TIFSRILDRSLPADILYEDQQCLVFRDVAPQAPVHFLVIPRKPIPRISQAEEDDQQLLGHLLLVAKKIAQAQGLKDGYRLVVNDGKMGAQSVYHLHIHVLGGRQLQWPPG 163
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Mouse
Match: Hint1 (histidine triad nucleotide binding protein 1 [Source:MGI Symbol;Acc:MGI:1321133]) HSP 1 Score: 166.392 bits (420), Expect = 3.621e-53 Identity = 76/127 (59.84%), Postives = 94/127 (74.02%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 E+ KA+ A GD TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ + A+D DE LLGHLMI+ K+ A L GYR+V+N G+DG QSV+H+HLH++GGRQM WPPG Sbjct: 4 EIAKAQVAQPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVADDDDESLLGHLMIVGKKCAADLGLKRGYRMVVNEGADGGQSVYHIHLHVLGGRQMNWPPG 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Mouse
Match: Hint1 (histidine triad nucleotide binding protein 1 [Source:MGI Symbol;Acc:MGI:1321133]) HSP 1 Score: 83.9593 bits (206), Expect = 6.967e-21 Identity = 43/80 (53.75%), Postives = 54/80 (67.50%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMI 324 E+ KA+ A GD TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ + A+D DE + L + Sbjct: 4 EIAKAQVAQPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVADDDDESVSKFLTL 79
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|P53795|HINT_CAEEL (Histidine triad nucleotide-binding protein 1 OS=Caenorhabditis elegans OX=6239 GN=hint-1 PE=4 SV=1) HSP 1 Score: 181.03 bits (458), Expect = 5.753e-58 Identity = 84/130 (64.62%), Postives = 103/130 (79.23%), Query Frame = 1 Query: 79 MSEVDKAKAACDSGD-KTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 MSEVDKA A + D + T+F KII K IPA I++ED+ LAF DVSPQAPIHFLVIPK+RI ML++A DSD L+G LM+ A +VAKQ ++NGYR+V+NNG DGAQSVFHLHLH++GGRQ+ WPPG Sbjct: 1 MSEVDKAHLAAINKDVQANDTLFGKIIRKEIPAKIIFEDDEALAFHDVSPQAPIHFLVIPKRRIDMLENAVDSDAALIGKLMVTASKVAKQLGMANGYRVVVNNGKDGAQSVFHLHLHVLGGRQLQWPPG 130
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|Q9BX68|HINT2_HUMAN (Histidine triad nucleotide-binding protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1) HSP 1 Score: 176.022 bits (445), Expect = 1.321e-55 Identity = 78/132 (59.09%), Postives = 103/132 (78.03%), Query Frame = 1 Query: 70 VRSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 V +EV KA+ A G TIF +I++K++PADILYED+ CL FRDV+PQAP+HFLVIPKK I + AE+ D+QLLGHL+++AK+ AK E L +GYR+VIN+G GAQSV+HLH+H++GGRQ+ WPPG Sbjct: 34 VTDGNEVAKAQQATPGGAAP--TIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG 163
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|Q9D0S9|HINT2_MOUSE (Histidine triad nucleotide-binding protein 2, mitochondrial OS=Mus musculus OX=10090 GN=Hint2 PE=1 SV=1) HSP 1 Score: 174.096 bits (440), Expect = 6.870e-55 Identity = 73/128 (57.03%), Postives = 103/128 (80.47%), Query Frame = 1 Query: 82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 SEV KA+ A G TIF +I+++++PADILYED+ CL FRDV+PQAP+HFLVIP+K I + AE+ D+QLLGHL+++AK++A+ + L +GYR+V+N+G GAQSV+HLH+H++GGRQ+ WPPG Sbjct: 38 SEVAKAQKAAPGGASP--TIFSRILDRSLPADILYEDQQCLVFRDVAPQAPVHFLVIPRKPIPRISQAEEDDQQLLGHLLLVAKKIAQAQGLKDGYRLVVNDGKMGAQSVYHLHIHVLGGRQLQWPPG 163
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|P62958|HINT1_BOVIN (Histidine triad nucleotide-binding protein 1 OS=Bos taurus OX=9913 GN=HINT1 PE=1 SV=2) HSP 1 Score: 172.17 bits (435), Expect = 1.247e-54 Identity = 79/127 (62.20%), Postives = 95/127 (74.80%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 E+ KA+ A GD TIF KII K IPA I+YED+ CLAF D+SPQAP HFLVIPKK I+ + +AED DE LLGHLMI+ K+ A L GYR+V+N GSDG QSV+H+HLH++GGRQM WPPG Sbjct: 4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIYEDDQCLAFHDISPQAPTHFLVIPKKYISQISAAEDDDESLLGHLMIVGKKCAADLGLKKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMNWPPG 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|P80912|HINT1_RABIT (Histidine triad nucleotide-binding protein 1 OS=Oryctolagus cuniculus OX=9986 GN=HINT1 PE=1 SV=2) HSP 1 Score: 171.785 bits (434), Expect = 2.063e-54 Identity = 78/127 (61.42%), Postives = 96/127 (75.59%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 E+ KA+ A GD TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ + +AED+DE LLGHLMI+ K+ A L GYR+V+N GSDG QSV+H+HLH++GGRQM WPPG Sbjct: 4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDQCLAFHDISPQAPTHFLVIPKKHISQISAAEDADESLLGHLMIVGKKCAADLGLKKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMNWPPG 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A183B396 (HIT domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS13681 PE=4 SV=1) HSP 1 Score: 197.978 bits (502), Expect = 2.498e-62 Identity = 87/128 (67.97%), Postives = 109/128 (85.16%), Query Frame = 1 Query: 82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 SEV+KA+ A GD TIF KIIN+ IPA+I+YED+SCLAF+D+SPQAP+HFLVIPK+RI+MLDSA+ DEQLLGH+M++ +VA Q+ LSNGYR+V+NNG DG QSVFHLHLH++GGRQ+ WPPG Sbjct: 3 SEVEKAQKA---GDTAEPTIFTKIINREIPANIIYEDDSCLAFKDISPQAPVHFLVIPKRRISMLDSAQSGDEQLLGHMMMVCSKVALQQGLSNGYRVVVNNGRDGCQSVFHLHLHVLGGRQLGWPPG 127
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A2H2HW24 (HIT domain-containing protein OS=Caenorhabditis japonica OX=281687 PE=4 SV=1) HSP 1 Score: 190.66 bits (483), Expect = 4.644e-59 Identity = 87/132 (65.91%), Postives = 107/132 (81.06%), Query Frame = 1 Query: 73 RSMSEVDKAKAACDSGD-KTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 R MSEVDKA+ A + D + T+F KII K IPA I++EDE LAF DVSPQAP+HFLVIPK+RI ML++A DSD L+G LM+ A +VAKQ NL++GYR+V+NNG DGAQSVFHLHLH++GGRQ+TWPPG Sbjct: 24 RKMSEVDKAQLAAINKDVQANDTLFGKIIRKEIPAKIIFEDEEALAFHDVSPQAPVHFLVIPKRRINMLENAVDSDAALIGKLMVTAAKVAKQLNLADGYRVVVNNGKDGAQSVFHLHLHVLGGRQLTWPPG 155
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A183PNH8 (HIT domain-containing protein OS=Schistosoma mattheei OX=31246 GN=SMTD_LOCUS15914 PE=4 SV=1) HSP 1 Score: 187.963 bits (476), Expect = 2.515e-58 Identity = 86/129 (66.67%), Postives = 105/129 (81.40%), Query Frame = 1 Query: 82 SEVDKAKAA-CDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 SEV+KAK + C G TIF KIINK IPADI+YED+ CLAFRD+SPQAP HFLVIPKK+I LDSA E+LLGHLM++ +VA++E L++GYR+V+NNG DGAQSV+HLHLH++GGRQM WPPG Sbjct: 3 SEVEKAKTSVCTQGP----TIFSKIINKEIPADIIYEDDDCLAFRDISPQAPTHFLVIPKKQIPTLDSASSEHEKLLGHLMLVCSQVAQKEGLTSGYRVVVNNGPDGAQSVYHLHLHVLGGRQMQWPPG 127
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A430Q485 (Histidine triad (HIT) family protein OS=Schistosoma bovis OX=6184 GN=DC041_0003146 PE=4 SV=1) HSP 1 Score: 186.422 bits (472), Expect = 8.475e-58 Identity = 85/129 (65.89%), Postives = 105/129 (81.40%), Query Frame = 1 Query: 82 SEVDKAKAA-CDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 SEV+KA+ + C G TIF KIINK IPADI+YED+ CLAFRD+SPQAP HFLVIPKK+I LDSA E+LLGHLM++ +VA++E L++GYR+V+NNG DGAQSV+HLHLH++GGRQM WPPG Sbjct: 3 SEVEKARTSVCTQGP----TIFSKIINKEIPADIIYEDDDCLAFRDISPQAPTHFLVIPKKQIPTLDSASSEHEKLLGHLMLVCSQVAQKEGLASGYRVVVNNGPDGAQSVYHLHLHVLGGRQMQWPPG 127
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A183JZT4 (HIT domain-containing protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS8242 PE=4 SV=1) HSP 1 Score: 186.422 bits (472), Expect = 8.475e-58 Identity = 85/129 (65.89%), Postives = 105/129 (81.40%), Query Frame = 1 Query: 82 SEVDKAKAA-CDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 SEV+KA+ + C G TIF KIINK IPADI+YED+ CLAFRD+SPQAP HFLVIPKK+I LDSA E+LLGHLM++ +VA++E L++GYR+V+NNG DGAQSV+HLHLH++GGRQM WPPG Sbjct: 3 SEVEKARTSVCTQGP----TIFSKIINKEIPADIIYEDDDCLAFRDISPQAPTHFLVIPKKQIPTLDSASSEHEKLLGHLMLVCSQVAQKEGLASGYRVVVNNGPDGAQSVYHLHLHVLGGRQMQWPPG 127
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Cavefish
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:NCBI gene;Acc:103038374]) HSP 1 Score: 171.785 bits (434), Expect = 2.446e-55 Identity = 78/128 (60.94%), Postives = 95/128 (74.22%), Query Frame = 1 Query: 82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 EV KA+ A GD TIF KII K IPA I+YEDE C+AF DV+PQAP HFLV+P+K I L AED D LLGHLMI+AK+ A+Q L GYR+V+N+G DG QSV+H+HLH++GGRQ+ WPPG Sbjct: 3 EEVAKAQTAQPGGD----TIFGKIIRKEIPAKIIYEDEQCIAFHDVAPQAPTHFLVVPRKPIVQLSKAEDGDAALLGHLMIVAKKCAEQVGLPRGYRLVVNDGPDGGQSVYHVHLHVLGGRQLGWPPG 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Cavefish
Match: hint2 (uncharacterized HIT-like protein Synpcc7942_1390 [Source:NCBI gene;Acc:103043014]) HSP 1 Score: 168.318 bits (425), Expect = 1.787e-53 Identity = 74/127 (58.27%), Postives = 96/127 (75.59%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 EV A+ A TIF K+I+KTIPADI++ED CLAFRD++PQAP+HFLVIP+ I + A D D LLGHL+++AK +AK+E L GYR+VIN+G +GAQSV+HLH+H++GGRQM WPPG Sbjct: 39 EVRLAQEASKKYGNPAPTIFSKVIDKTIPADIIFEDYKCLAFRDINPQAPVHFLVIPRTPIPRISEAHDDDALLLGHLLVVAKNLAKKEGLDEGYRVVINDGKNGAQSVYHLHIHVLGGRQMQWPPG 165
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Cavefish
Match: hint3 (histidine triad nucleotide binding protein 3 [Source:NCBI gene;Acc:103030469]) HSP 1 Score: 67.3958 bits (163), Expect = 3.427e-14 Identity = 38/119 (31.93%), Postives = 60/119 (50.42%), Query Frame = 1 Query: 82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438 +E D + DS DK IF KI+N+ + ++L+ DE FRD+ P AP H+LV+P K + S L+ LM K + ++ N+++ + SV HLHLH++ Sbjct: 10 AEPDNKQQPSDSYDKK--CIFCKIVNREMDTELLHSDEEISCFRDIKPGAPHHYLVVPTKHVGNCKSLNKEHIPLVEKLMETGKTILQKNNVTDLNDVRFGFHWPPFHSVVHLHLHVLA 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002976.1 (pep scaffold:Pmarinus_7.0:GL478213:18376:23079:1 gene:ENSPMAG00000002715.1 transcript:ENSPMAT00000002976.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 175.637 bits (444), Expect = 5.904e-57 Identity = 81/130 (62.31%), Postives = 101/130 (77.69%), Query Frame = 1 Query: 85 EVDKAKAACDSGDK---TRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 EV +AK A +K + TIF KII++ IPADIL+ED+ CLAFRD+SPQAP HFLVIPK RI + A+ D QLLGHL+ IAK +AK+E L NGYR+VIN+G DG+QSV+HLH+H++GGRQM WPPG Sbjct: 45 EVTRAKLAAQEWEKHGINKPTIFSKIISREIPADILHEDDMCLAFRDISPQAPTHFLVIPKLRIPRISQAQSQDTQLLGHLLFIAKTLAKKEGLDNGYRVVINDGPDGSQSVYHLHVHVIGGRQMLWPPG 174
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Sea Lamprey
Match: hint1 (histidine triad nucleotide binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-040927-8]) HSP 1 Score: 162.155 bits (409), Expect = 4.691e-52 Identity = 75/127 (59.06%), Postives = 95/127 (74.80%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 EV KA AA GD TIF KII K IPA+I++EDE C+ F DV+PQAP H LV+PKK I L +A D+ LLGHLM++A +VA Q LS+GYR+V+N+G +G QSV+HLHLH++GGRQ+ WPPG Sbjct: 24 EVAKALAARPGGD----TIFGKIIRKEIPANIIHEDEQCIVFHDVAPQAPTHLLVVPKKAIPGLPNATAEDQALLGHLMLVAAKVAAQVGLSSGYRLVLNDGPEGGQSVYHLHLHVLGGRQLGWPPG 146
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Yeast
Match: HNT1 (Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of histidine triad (HIT) superfamily of nucleotide-binding proteins; protein abundance increases in response to DNA replication stress; human homolog HINT1 can complement yeast hnt1 mutant [Source:SGD;Acc:S000002283]) HSP 1 Score: 61.2326 bits (147), Expect = 7.129e-13 Identity = 42/113 (37.17%), Postives = 56/113 (49.56%), Query Frame = 1 Query: 139 IFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQ------MTWP 459 IF KII IP+ L E + AF D+ P A H L+IPK L D ++ L M IAKR+AK L + Y ++ NNG Q V H+H H++ R + WP Sbjct: 26 IFCKIIKSEIPSFKLIETKYSYAFLDIQPTAEGHALIIPKYHGAKL---HDIPDEFLTDAMPIAKRLAKAMKL-DTYNVLQNNGKIAHQEVDHVHFHLIPKRDEKSGLIVGWP 134
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO31701 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX81]) HSP 1 Score: 162.925 bits (411), Expect = 1.949e-52 Identity = 74/111 (66.67%), Postives = 92/111 (82.88%), Query Frame = 1 Query: 136 TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSN-GYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 TIF KII K IPA+IL+ED+ CLAFRD++PQAP H LVIPKK I L A+DSDEQLLG L+I+A++VA +NL+N GYRI+IN+G +G Q VFHLH+HI+GGR+M WPPG Sbjct: 6 TIFGKIIRKEIPAEILHEDDQCLAFRDINPQAPTHVLVIPKKPIRQLSMADDSDEQLLGRLLIVARKVAAMQNLANDGYRIIINDGKNGGQEVFHLHVHILGGRKMKWPPG 116
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO45654 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSL2]) HSP 1 Score: 141.354 bits (355), Expect = 9.018e-44 Identity = 65/128 (50.78%), Postives = 94/128 (73.44%), Query Frame = 1 Query: 82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLS-NGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPP 462 SE +KA++A GD TIF +II +PA ++ED+ C+A D++PQAP+HFLVIPK I L A++ + +LLGH +++AK VAK + +S +G+R+VIN+G G QSV+HLHLH++GGRQ+ WPP Sbjct: 3 SEEEKAQSAVPGGD----TIFSRIIRGDVPATFIHEDDKCIAMDDINPQAPVHFLVIPKTPIQKLSLAQNWNAELLGHCLLVAKDVAKNKGISEDGFRVVINDGRHGCQSVYHLHLHVIGGRQLGWPP 126
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO37394 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFV5]) HSP 1 Score: 62.003 bits (149), Expect = 1.244e-12 Identity = 38/106 (35.85%), Postives = 55/106 (51.89%), Query Frame = 1 Query: 121 DKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438 +K + +F KI +K I+YEDE L F+D+ P H+LVIPK+ S D L+ LM + K+V Q+N +N VI S+ HLHLH++ Sbjct: 6 EKLKKCVFCKISSKEQETRIIYEDEETLTFKDLRPATDHHYLVIPKQHYGNPKSLTGDDLPLVEKLMDVGKKVLVQQN-ANTEDTVIGFHWPPFNSIQHLHLHVIS 110
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO26907 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TAR3]) HSP 1 Score: 51.2174 bits (121), Expect = 4.241e-9 Identity = 30/70 (42.86%), Postives = 42/70 (60.00%), Query Frame = 1 Query: 136 TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAK 345 +IF KIIN+ IP+ + ED++ AF D++P A H LVIPKK + D D D + L+ A +VAK Sbjct: 3 SIFTKIINREIPSYKVAEDKNYYAFLDINPNAKGHTLVIPKKEV---DKLFDLDAETYTGLLQFAYKVAK 69
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO32029 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWA8]) HSP 1 Score: 43.1282 bits (100), Expect = 9.610e-6 Identity = 34/104 (32.69%), Postives = 50/104 (48.08%), Query Frame = 1 Query: 142 FDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPK---KRITMLDSAEDSDEQLLGHLMIIAKRVA---KQENLSNGYRIVINNGSDGAQSVFHLHLHIM 435 F II K P+ + Y + F ++ P P H LV P KR L E SD L I ++R+A ++E + I I +G + QSV H+H+HI+ Sbjct: 10 FGHIILK--PSVVFYRSNLSIGFVNIKPVLPGHVLVSPVRVVKRFVDLTQDEVSD------LFISSQRIAGVVEREFGATSLTISIQDGPEAGQSVQHVHVHIL 105
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: hint2 (histidine triad nucleotide-binding protein 2, mitochondrial [Source:NCBI gene;Acc:101167460]) HSP 1 Score: 177.948 bits (450), Expect = 3.931e-57 Identity = 75/110 (68.18%), Postives = 97/110 (88.18%), Query Frame = 1 Query: 136 TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 TIF K+I+K+IPADI+YED CLAFRD+SPQAP+HFLVIP+ I + +AED+D +LLGHL+++AK VAKQE+LS+GYR+VIN+G GAQSV+HLH+H++GGRQM WPPG Sbjct: 72 TIFSKVIDKSIPADIIYEDHMCLAFRDISPQAPVHFLVIPRTPIPRISAAEDADAELLGHLLVVAKNVAKQESLSDGYRVVINDGKHGAQSVYHLHVHVLGGRQMKWPPG 181
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:NCBI gene;Acc:101161990]) HSP 1 Score: 162.155 bits (409), Expect = 3.349e-51 Identity = 72/127 (56.69%), Postives = 93/127 (73.23%), Query Frame = 1 Query: 85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 E +KA+ A GD TIF KI+ K IP ++LYED+ C+AF D+SPQAP H LV+PKK I L AE+ D LLGH++I+AK+ AK L+ GYRIVIN+G DG QSV+H+H+H++GGR M WPPG Sbjct: 35 ETEKAQTARPGGD----TIFGKIVRKEIPVNLLYEDDQCVAFPDISPQAPTHILVVPKKPIVQLSVAEEDDAALLGHMLIVAKKCAKDAGLTKGYRIVINDGPDGGQSVYHVHIHVLGGRMMGWPPG 157
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: hint3 (histidine triad nucleotide binding protein 3 [Source:ZFIN;Acc:ZDB-GENE-100922-168]) HSP 1 Score: 61.2326 bits (147), Expect = 5.067e-12 Identity = 30/103 (29.13%), Postives = 53/103 (51.46%), Query Frame = 1 Query: 130 RHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438 + IF +I+N+ + ++LY DE FRD+ P AP H+LV+P + + S L+ L+ + K + ++ N+ + + SV HLHLH++ Sbjct: 19 KKCIFCRIVNREMGTELLYSDEEISCFRDIKPGAPHHYLVVPTQHVGNCKSLSKEHVPLVNRLVDVGKEILQKNNVMDLSDVRFGFHWPPFCSVTHLHLHVLA 121
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: ENSORLT00000036728.1 (histidine triad nucleotide-binding protein 3 [Source:NCBI gene;Acc:101174317]) HSP 1 Score: 50.447 bits (119), Expect = 7.700e-8 Identity = 27/95 (28.42%), Postives = 50/95 (52.63%), Query Frame = 1 Query: 172 ADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGG-RQMT 453 +++ +D+ + FRD+ P AP H+LVIP+ I S L+ + + K V +++ ++N + + SV HLHLH++ RQ++ Sbjct: 25 TEVIKQDKKLVCFRDIWPAAPHHYLVIPRAHIHSCRSLSGEHIHLVDRMTSMGKDVLREQGITNMEDVRLGFHQPPFISVGHLHLHVLAPVRQIS 119
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: aptx (aprataxin [Source:NCBI gene;Acc:101162025]) HSP 1 Score: 47.3654 bits (111), Expect = 1.929e-6 Identity = 28/91 (30.77%), Postives = 50/91 (54.95%), Query Frame = 1 Query: 169 PADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQ--ENLSNGYRIVINNGSDGAQSVFHLHLHIM 435 P +Y+D++ + +D P+A H+LV+P + I L + + LL H+ +A+R+ KQ E+ S +R G S+ H+HLH++ Sbjct: 169 PKMQIYKDDTVVVIKDKYPKARYHWLVLPWQSIPSLKALKAEHCDLLKHMQKVAERMIKQCPESSSLSFR----TGYHAIPSMSHIHLHVI 255
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000067518.1 (SMESG000067518.1) HSP 1 Score: 281.952 bits (720), Expect = 1.153e-98 Identity = 151/152 (99.34%), Postives = 151/152 (99.34%), Query Frame = 1 Query: 10 MYHXXXXXXXXXXXXXXXFFVRSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 MYHSISKIINSLSKSNIKFFVRSMSEVDKAKAACDSGDKTR TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG Sbjct: 1 MYHSISKIINSLSKSNIKFFVRSMSEVDKAKAACDSGDKTRPTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 152
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000067518.1 (SMESG000067518.1) HSP 1 Score: 266.929 bits (681), Expect = 3.653e-93 Identity = 128/129 (99.22%), Postives = 128/129 (99.22%), Query Frame = 1 Query: 79 MSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 MSEVDKAKAACDSGDKTR TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG Sbjct: 1 MSEVDKAKAACDSGDKTRPTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 129
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000060398.1 (SMESG000060398.1) HSP 1 Score: 224.172 bits (570), Expect = 4.392e-76 Identity = 128/152 (84.21%), Postives = 131/152 (86.18%), Query Frame = 1 Query: 10 MYHXXXXXXXXXXXXXXXFFVRSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 MYHSISKIINSLSKSNI+FFVRSMSEVDKAKAACDSGDKTR TIFDKIINKTIPADILYEDE+ F + ITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG Sbjct: 1 MYHSISKIINSLSKSNIQFFVRSMSEVDKAKAACDSGDKTRPTIFDKIINKTIPADILYEDEAVWLF----------------EIITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 136
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000060398.1 (SMESG000060398.1) HSP 1 Score: 209.92 bits (533), Expect = 1.050e-70 Identity = 106/129 (82.17%), Postives = 108/129 (83.72%), Query Frame = 1 Query: 79 MSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 MSEVDKAKAACDSGDKTR TIFDKIINKTIPADILYEDE+ F + ITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG Sbjct: 1 MSEVDKAKAACDSGDKTRPTIFDKIINKTIPADILYEDEAVWLF----------------EIITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 113
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000004839.1 (SMESG000004839.1) HSP 1 Score: 140.198 bits (352), Expect = 9.285e-43 Identity = 58/124 (46.77%), Postives = 88/124 (70.97%), Query Frame = 1 Query: 94 KAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465 K+ C K+ ++F KIIN+ +PA ILYED+ C+AF +S + FLV+P K+I L+ A++ D LLGHLM++A ++A+++ +NGYR+VINNG D Q V HLH+H+ GG++++WPPG Sbjct: 23 KSFQQCKFQAKSEPSVFTKIINRELPATILYEDDKCIAFLSLSRPTKVKFLVVPLKQIATLEEAQECDANLLGHLMLVASKIAREQGANNGYRLVINNGPDALQDVPHLHIHVYGGQKLSWPPG 146 The following BLAST results are available for this feature:
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 3
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 3
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 3
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 3
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 2
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30030230 ID=SMED30030230|Name=Histidine triad nucleotide-binding protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=534bpback to top protein sequence of SMED30030230-orf-1 >SMED30030230-orf-1 ID=SMED30030230-orf-1|Name=SMED30030230-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=153bp MYHSISKIINSLSKSNIKFFVRSMSEVDKAKAACDSGDKTRHTIFDKIINback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|