Histidine triad nucleotide-binding protein 1

Overview
NameHistidine triad nucleotide-binding protein 1
Smed IDSMED30030230
Length (bp)534
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Histidine triad nucleotide-binding protein 1 (SMED30030230) t-SNE clustered cells

Violin plots show distribution of expression levels for Histidine triad nucleotide-binding protein 1 (SMED30030230) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Histidine triad nucleotide-binding protein 1 (SMED30030230) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Histidine triad nucleotide-binding protein 1 (SMED30030230) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30030230

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30030230h1SMcG0002853 SmedASXL_014023SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
nervous systemSMED30030230h1SMcG0002853 dd_Smed_v4_3055_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30030230h1SMcG0002853 dd_Smed_v4_3055_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30030230h1SMcG0002853 dd_Smed_v4_8047_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30030230h1SMcG0002853 dd_Smed_v4_8047_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT2 (histidine triad nucleotide binding protein 2 [Source:HGNC Symbol;Acc:HGNC:18344])

HSP 1 Score: 176.022 bits (445), Expect = 2.750e-56
Identity = 78/132 (59.09%), Postives = 103/132 (78.03%), Query Frame = 1
Query:   70 VRSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            V   +EV KA+ A   G     TIF +I++K++PADILYED+ CL FRDV+PQAP+HFLVIPKK I  +  AE+ D+QLLGHL+++AK+ AK E L +GYR+VIN+G  GAQSV+HLH+H++GGRQ+ WPPG
Sbjct:   34 VTDGNEVAKAQQATPGGAAP--TIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG 163          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4912])

HSP 1 Score: 168.703 bits (426), Expect = 6.682e-54
Identity = 78/127 (61.42%), Postives = 95/127 (74.80%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            E+ KA+ A   GD    TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ +  AED DE LLGHLMI+ K+ A    L+ GYR+V+N GSDG QSV+H+HLH++GGRQM WPPG
Sbjct:    4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4912])

HSP 1 Score: 88.5817 bits (218), Expect = 4.814e-23
Identity = 45/79 (56.96%), Postives = 55/79 (69.62%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLM 321
            E+ KA+ A   GD    TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ +  AED DE  + +LM
Sbjct:    4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESSVEYLM 78          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4912])

HSP 1 Score: 85.5001 bits (210), Expect = 8.715e-22
Identity = 43/74 (58.11%), Postives = 52/74 (70.27%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQL 306
            E+ KA+ A   GD    TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ +  AED DE +
Sbjct:    4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESV 73          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:HGNC Symbol;Acc:HGNC:4912])

HSP 1 Score: 86.2705 bits (212), Expect = 8.818e-22
Identity = 43/75 (57.33%), Postives = 53/75 (70.67%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLL 309
            E+ KA+ A   GD    TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ +  AED DE ++
Sbjct:    4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESVI 74          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Celegans
Match: hint-1 (Histidine triad nucleotide-binding protein 1 [Source:UniProtKB/Swiss-Prot;Acc:P53795])

HSP 1 Score: 181.03 bits (458), Expect = 4.523e-59
Identity = 84/130 (64.62%), Postives = 103/130 (79.23%), Query Frame = 1
Query:   79 MSEVDKAKAACDSGD-KTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            MSEVDKA  A  + D +   T+F KII K IPA I++ED+  LAF DVSPQAPIHFLVIPK+RI ML++A DSD  L+G LM+ A +VAKQ  ++NGYR+V+NNG DGAQSVFHLHLH++GGRQ+ WPPG
Sbjct:    1 MSEVDKAHLAAINKDVQANDTLFGKIIRKEIPAKIIFEDDEALAFHDVSPQAPIHFLVIPKRRIDMLENAVDSDAALIGKLMVTASKVAKQLGMANGYRVVVNNGKDGAQSVFHLHLHVLGGRQLQWPPG 130          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Celegans
Match: hint-1 (Histidine triad nucleotide-binding protein 1 [Source:UniProtKB/Swiss-Prot;Acc:P53795])

HSP 1 Score: 181.03 bits (458), Expect = 4.523e-59
Identity = 84/130 (64.62%), Postives = 103/130 (79.23%), Query Frame = 1
Query:   79 MSEVDKAKAACDSGD-KTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            MSEVDKA  A  + D +   T+F KII K IPA I++ED+  LAF DVSPQAPIHFLVIPK+RI ML++A DSD  L+G LM+ A +VAKQ  ++NGYR+V+NNG DGAQSVFHLHLH++GGRQ+ WPPG
Sbjct:    1 MSEVDKAHLAAINKDVQANDTLFGKIIRKEIPAKIIFEDDEALAFHDVSPQAPIHFLVIPKRRIDMLENAVDSDAALIGKLMVTASKVAKQLGMANGYRVVVNNGKDGAQSVFHLHLHVLGGRQLQWPPG 130          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Celegans
Match: nft-1 (Nitrilase and fragile histidine triad fusion protein NitFhit Bis(5'-adenosyl)-triphosphatase Nitrilase homolog [Source:UniProtKB/Swiss-Prot;Acc:O76463])

HSP 1 Score: 50.0618 bits (118), Expect = 2.091e-7
Identity = 39/116 (33.62%), Postives = 57/116 (49.14%), Query Frame = 1
Query:  121 DKTRHTIFDKIINKTIPAD-ILYEDESCLAFRDVSPQAPIHFLVIPKK---RITMLDSAEDSDEQLLGHLMIIAKRVA----KQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGR 444
            +K+  T   K     IPAD I Y       F ++ P    H LV PK+   R+T L  AE +D      L I+AK+V     K  N+++   I + +G D  Q+V H+H+HI+  R
Sbjct:  291 EKSSETGGLKFARFNIPADHIFYSTPHSFVFVNLKPVTDGHVLVSPKRVVPRLTDLTDAETAD------LFIVAKKVQAMLEKHHNVTST-TICVQDGKDAGQTVPHVHIHILPRR 399          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Fly
Match: CG2862 (gene:FBgn0031459 transcript:FBtr0335128)

HSP 1 Score: 167.933 bits (424), Expect = 1.302e-53
Identity = 77/131 (58.78%), Postives = 97/131 (74.05%), Query Frame = 1
Query:   73 RSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            R  SEV+K++ A  S D    TIF KI+ K IP   ++ED+ C+AF DV+PQAP HFLVIP+K I  L  AED D  LLGHLM++ ++VAK+  L++GYR+VINNG  GAQSV+HLHLH +GGRQM WPPG
Sbjct:   24 RMASEVEKSQTAAASED----TIFGKILRKEIPCKFIHEDDKCVAFHDVAPQAPTHFLVIPRKPIAQLSLAEDGDADLLGHLMLVGRKVAKELGLADGYRVVINNGKHGAQSVYHLHLHFLGGRQMQWPPG 150          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Fly
Match: CG2862 (gene:FBgn0031459 transcript:FBtr0077718)

HSP 1 Score: 167.933 bits (424), Expect = 1.302e-53
Identity = 77/131 (58.78%), Postives = 97/131 (74.05%), Query Frame = 1
Query:   73 RSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            R  SEV+K++ A  S D    TIF KI+ K IP   ++ED+ C+AF DV+PQAP HFLVIP+K I  L  AED D  LLGHLM++ ++VAK+  L++GYR+VINNG  GAQSV+HLHLH +GGRQM WPPG
Sbjct:   24 RMASEVEKSQTAAASED----TIFGKILRKEIPCKFIHEDDKCVAFHDVAPQAPTHFLVIPRKPIAQLSLAEDGDADLLGHLMLVGRKVAKELGLADGYRVVINNGKHGAQSVYHLHLHFLGGRQMQWPPG 150          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Fly
Match: CG2862 (gene:FBgn0031459 transcript:FBtr0077719)

HSP 1 Score: 166.007 bits (419), Expect = 3.110e-53
Identity = 76/128 (59.38%), Postives = 96/128 (75.00%), Query Frame = 1
Query:   82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            SEV+K++ A  S D    TIF KI+ K IP   ++ED+ C+AF DV+PQAP HFLVIP+K I  L  AED D  LLGHLM++ ++VAK+  L++GYR+VINNG  GAQSV+HLHLH +GGRQM WPPG
Sbjct:    3 SEVEKSQTAAASED----TIFGKILRKEIPCKFIHEDDKCVAFHDVAPQAPTHFLVIPRKPIAQLSLAEDGDADLLGHLMLVGRKVAKELGLADGYRVVINNGKHGAQSVYHLHLHFLGGRQMQWPPG 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: hint1 (histidine triad nucleotide binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-040927-8])

HSP 1 Score: 168.318 bits (425), Expect = 6.654e-54
Identity = 72/127 (56.69%), Postives = 100/127 (78.74%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            EV +A++A   GD    TIF KII K IPA+I+YED+ C+AF DV+PQAP HFLV+P+K I+ +   ED+D++LLGH+MI+AK+ A+Q  L  GYR+V+N+G DG QSV+H+H+H++GGRQ+ WPPG
Sbjct:    4 EVSRAQSAQPGGD----TIFGKIIRKEIPANIIYEDDQCIAFNDVAPQAPTHFLVVPRKPISQISKVEDADKELLGHMMIVAKKCAEQVGLPRGYRLVVNDGPDGGQSVYHIHIHVLGGRQLGWPPG 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: hint1 (histidine triad nucleotide binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-040927-8])

HSP 1 Score: 168.318 bits (425), Expect = 6.654e-54
Identity = 72/127 (56.69%), Postives = 100/127 (78.74%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            EV +A++A   GD    TIF KII K IPA+I+YED+ C+AF DV+PQAP HFLV+P+K I+ +   ED+D++LLGH+MI+AK+ A+Q  L  GYR+V+N+G DG QSV+H+H+H++GGRQ+ WPPG
Sbjct:    4 EVSRAQSAQPGGD----TIFGKIIRKEIPANIIYEDDQCIAFNDVAPQAPTHFLVVPRKPISQISKVEDADKELLGHMMIVAKKCAEQVGLPRGYRLVVNDGPDGGQSVYHIHIHVLGGRQLGWPPG 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: hint2 (histidine triad nucleotide binding protein 2 [Source:ZFIN;Acc:ZDB-GENE-070410-139])

HSP 1 Score: 169.088 bits (427), Expect = 7.938e-54
Identity = 74/127 (58.27%), Postives = 98/127 (77.17%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            EV  A+ A     K   TIF KII+KT+PA I+YED+ CLAFRDV+PQAP+H+LVIP+  I  +  A D D  +LGHL+++AK +AK+E L+ GYR+VIN+G +GAQSV+HLH+H++GGRQM WPPG
Sbjct:   35 EVRLAQEASKKYGKLEPTIFTKIIDKTVPAVIIYEDDKCLAFRDVNPQAPVHYLVIPRIPIPRISEAHDEDSLILGHLLVVAKNIAKKEGLAEGYRVVINDGKNGAQSVYHLHIHVLGGRQMKWPPG 161          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: si:dkey-25e12.3 (si:dkey-25e12.3 [Source:NCBI gene;Acc:678527])

HSP 1 Score: 55.8398 bits (133), Expect = 8.043e-10
Identity = 32/89 (35.96%), Postives = 48/89 (53.93%), Query Frame = 1
Query:  172 ADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438
             +IL EDE  + FRD++P AP H+LVIPKK I    S    D  L+  +  + + V K  N+++   I +        +V HLHLH++ 
Sbjct:   36 TEILAEDEDFVCFRDINPGAPHHYLVIPKKHIYSCLSLYADDISLVRGMAEMGRNVLKANNVTDLKDISLGFHVPPYITVPHLHLHVLA 124          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Match: si:dkey-25e12.3 (si:dkey-25e12.3 [Source:NCBI gene;Acc:678527])

HSP 1 Score: 55.4546 bits (132), Expect = 9.098e-10
Identity = 32/89 (35.96%), Postives = 48/89 (53.93%), Query Frame = 1
Query:  172 ADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438
             +IL EDE  + FRD++P AP H+LVIPKK I    S    D  L+  +  + + V K  N+++   I +        +V HLHLH++ 
Sbjct:   36 TEILAEDEDFVCFRDINPGAPHHYLVIPKKHIYSCLSLYADDISLVRGMAEMGRNVLKANNVTDLKDISLGFHVPPYITVPHLHLHVLA 124          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Xenopus
Match: hint1 (histidine triad nucleotide binding protein 1 [Source:NCBI gene;Acc:548919])

HSP 1 Score: 173.711 bits (439), Expect = 5.560e-56
Identity = 77/127 (60.63%), Postives = 95/127 (74.80%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            E+ KA+ AC  GD    TIF KII K IPA I+YEDE C+AF D++PQAP+HFLV+PKK IT L  A+ +DE+LLGHLMI+  + A    L+NGYR+ +N G DG QSV+HLHLH+ GGRQM WPPG
Sbjct:    4 EISKAQTACPGGD----TIFGKIIRKEIPAKIIYEDEQCIAFHDIAPQAPVHFLVVPKKFITHLSKADPADEKLLGHLMIVGSKCAADLGLTNGYRLAVNEGPDGGQSVYHLHLHVFGGRQMGWPPG 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Xenopus
Match: sirt3.2 (sirtuin (silent mating type information regulation 2 homolog) 3, gene 2 [Source:Xenbase;Acc:XB-GENE-5721494])

HSP 1 Score: 105.916 bits (263), Expect = 1.752e-28
Identity = 53/113 (46.90%), Postives = 73/113 (64.60%), Query Frame = 1
Query:   85 EVDKAKAAC---DSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDE-------------QLLGHLMIIAKRVAKQENLSNGYRI 375
            EV KA+ A    + G  +  TIF +II++T+PADI++ED+ C+AFRDV+PQAP+HFLVIPK  I  L     SD              QLLGHL++ A R+A +E L++GYR+
Sbjct:   59 EVQKAQRAAAERNGGSPSPPTIFSRIIDRTLPADIIHEDDKCVAFRDVNPQAPVHFLVIPKTPIARLSQVNASDTELQTNWLHVCFSLQLLGHLLVTASRLAHKEGLADGYRL 171          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Xenopus
Match: cks2 (CDC28 protein kinase regulatory subunit 2 [Source:Xenbase;Acc:XB-GENE-922081])

HSP 1 Score: 52.7582 bits (125), Expect = 1.420e-8
Identity = 29/101 (28.71%), Postives = 53/101 (52.48%), Query Frame = 1
Query:  139 IFDKIINKTIP-ADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438
            IF +I NK    A++L+ D+  + F+D+ P    H+LV+PKK +    +      QL+  +M + K   ++ N+++   I +        S+ HLHLH++ 
Sbjct:   20 IFCRIANKQESGAELLHSDDDLVCFKDIRPAVTHHYLVVPKKHVGTCKTLTKDHVQLIKTMMEVGKSTLQKNNVTDLEDIRLGFHYPPFCSISHLHLHVLA 120          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Mouse
Match: Hint2 (histidine triad nucleotide binding protein 2 [Source:MGI Symbol;Acc:MGI:1916167])

HSP 1 Score: 174.096 bits (440), Expect = 9.822e-56
Identity = 73/128 (57.03%), Postives = 103/128 (80.47%), Query Frame = 1
Query:   82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            SEV KA+ A   G     TIF +I+++++PADILYED+ CL FRDV+PQAP+HFLVIP+K I  +  AE+ D+QLLGHL+++AK++A+ + L +GYR+V+N+G  GAQSV+HLH+H++GGRQ+ WPPG
Sbjct:   38 SEVAKAQKAAPGGASP--TIFSRILDRSLPADILYEDQQCLVFRDVAPQAPVHFLVIPRKPIPRISQAEEDDQQLLGHLLLVAKKIAQAQGLKDGYRLVVNDGKMGAQSVYHLHIHVLGGRQLQWPPG 163          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Mouse
Match: Hint1 (histidine triad nucleotide binding protein 1 [Source:MGI Symbol;Acc:MGI:1321133])

HSP 1 Score: 166.392 bits (420), Expect = 3.621e-53
Identity = 76/127 (59.84%), Postives = 94/127 (74.02%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            E+ KA+ A   GD    TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ +  A+D DE LLGHLMI+ K+ A    L  GYR+V+N G+DG QSV+H+HLH++GGRQM WPPG
Sbjct:    4 EIAKAQVAQPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVADDDDESLLGHLMIVGKKCAADLGLKRGYRMVVNEGADGGQSVYHIHLHVLGGRQMNWPPG 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Mouse
Match: Hint1 (histidine triad nucleotide binding protein 1 [Source:MGI Symbol;Acc:MGI:1321133])

HSP 1 Score: 83.9593 bits (206), Expect = 6.967e-21
Identity = 43/80 (53.75%), Postives = 54/80 (67.50%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMI 324
            E+ KA+ A   GD    TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ +  A+D DE +   L +
Sbjct:    4 EIAKAQVAQPGGD----TIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVADDDDESVSKFLTL 79          
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|P53795|HINT_CAEEL (Histidine triad nucleotide-binding protein 1 OS=Caenorhabditis elegans OX=6239 GN=hint-1 PE=4 SV=1)

HSP 1 Score: 181.03 bits (458), Expect = 5.753e-58
Identity = 84/130 (64.62%), Postives = 103/130 (79.23%), Query Frame = 1
Query:   79 MSEVDKAKAACDSGD-KTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            MSEVDKA  A  + D +   T+F KII K IPA I++ED+  LAF DVSPQAPIHFLVIPK+RI ML++A DSD  L+G LM+ A +VAKQ  ++NGYR+V+NNG DGAQSVFHLHLH++GGRQ+ WPPG
Sbjct:    1 MSEVDKAHLAAINKDVQANDTLFGKIIRKEIPAKIIFEDDEALAFHDVSPQAPIHFLVIPKRRIDMLENAVDSDAALIGKLMVTASKVAKQLGMANGYRVVVNNGKDGAQSVFHLHLHVLGGRQLQWPPG 130          
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|Q9BX68|HINT2_HUMAN (Histidine triad nucleotide-binding protein 2, mitochondrial OS=Homo sapiens OX=9606 GN=HINT2 PE=1 SV=1)

HSP 1 Score: 176.022 bits (445), Expect = 1.321e-55
Identity = 78/132 (59.09%), Postives = 103/132 (78.03%), Query Frame = 1
Query:   70 VRSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            V   +EV KA+ A   G     TIF +I++K++PADILYED+ CL FRDV+PQAP+HFLVIPKK I  +  AE+ D+QLLGHL+++AK+ AK E L +GYR+VIN+G  GAQSV+HLH+H++GGRQ+ WPPG
Sbjct:   34 VTDGNEVAKAQQATPGGAAP--TIFSRILDKSLPADILYEDQQCLVFRDVAPQAPVHFLVIPKKPIPRISQAEEEDQQLLGHLLLVAKQTAKAEGLGDGYRLVINDGKLGAQSVYHLHIHVLGGRQLQWPPG 163          
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|Q9D0S9|HINT2_MOUSE (Histidine triad nucleotide-binding protein 2, mitochondrial OS=Mus musculus OX=10090 GN=Hint2 PE=1 SV=1)

HSP 1 Score: 174.096 bits (440), Expect = 6.870e-55
Identity = 73/128 (57.03%), Postives = 103/128 (80.47%), Query Frame = 1
Query:   82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            SEV KA+ A   G     TIF +I+++++PADILYED+ CL FRDV+PQAP+HFLVIP+K I  +  AE+ D+QLLGHL+++AK++A+ + L +GYR+V+N+G  GAQSV+HLH+H++GGRQ+ WPPG
Sbjct:   38 SEVAKAQKAAPGGASP--TIFSRILDRSLPADILYEDQQCLVFRDVAPQAPVHFLVIPRKPIPRISQAEEDDQQLLGHLLLVAKKIAQAQGLKDGYRLVVNDGKMGAQSVYHLHIHVLGGRQLQWPPG 163          
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|P62958|HINT1_BOVIN (Histidine triad nucleotide-binding protein 1 OS=Bos taurus OX=9913 GN=HINT1 PE=1 SV=2)

HSP 1 Score: 172.17 bits (435), Expect = 1.247e-54
Identity = 79/127 (62.20%), Postives = 95/127 (74.80%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            E+ KA+ A   GD    TIF KII K IPA I+YED+ CLAF D+SPQAP HFLVIPKK I+ + +AED DE LLGHLMI+ K+ A    L  GYR+V+N GSDG QSV+H+HLH++GGRQM WPPG
Sbjct:    4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIYEDDQCLAFHDISPQAPTHFLVIPKKYISQISAAEDDDESLLGHLMIVGKKCAADLGLKKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMNWPPG 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Match: sp|P80912|HINT1_RABIT (Histidine triad nucleotide-binding protein 1 OS=Oryctolagus cuniculus OX=9986 GN=HINT1 PE=1 SV=2)

HSP 1 Score: 171.785 bits (434), Expect = 2.063e-54
Identity = 78/127 (61.42%), Postives = 96/127 (75.59%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            E+ KA+ A   GD    TIF KII K IPA I++ED+ CLAF D+SPQAP HFLVIPKK I+ + +AED+DE LLGHLMI+ K+ A    L  GYR+V+N GSDG QSV+H+HLH++GGRQM WPPG
Sbjct:    4 EIAKAQVARPGGD----TIFGKIIRKEIPAKIIFEDDQCLAFHDISPQAPTHFLVIPKKHISQISAAEDADESLLGHLMIVGKKCAADLGLKKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMNWPPG 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A183B396 (HIT domain-containing protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS13681 PE=4 SV=1)

HSP 1 Score: 197.978 bits (502), Expect = 2.498e-62
Identity = 87/128 (67.97%), Postives = 109/128 (85.16%), Query Frame = 1
Query:   82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            SEV+KA+ A   GD    TIF KIIN+ IPA+I+YED+SCLAF+D+SPQAP+HFLVIPK+RI+MLDSA+  DEQLLGH+M++  +VA Q+ LSNGYR+V+NNG DG QSVFHLHLH++GGRQ+ WPPG
Sbjct:    3 SEVEKAQKA---GDTAEPTIFTKIINREIPANIIYEDDSCLAFKDISPQAPVHFLVIPKRRISMLDSAQSGDEQLLGHMMMVCSKVALQQGLSNGYRVVVNNGRDGCQSVFHLHLHVLGGRQLGWPPG 127          
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A2H2HW24 (HIT domain-containing protein OS=Caenorhabditis japonica OX=281687 PE=4 SV=1)

HSP 1 Score: 190.66 bits (483), Expect = 4.644e-59
Identity = 87/132 (65.91%), Postives = 107/132 (81.06%), Query Frame = 1
Query:   73 RSMSEVDKAKAACDSGD-KTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            R MSEVDKA+ A  + D +   T+F KII K IPA I++EDE  LAF DVSPQAP+HFLVIPK+RI ML++A DSD  L+G LM+ A +VAKQ NL++GYR+V+NNG DGAQSVFHLHLH++GGRQ+TWPPG
Sbjct:   24 RKMSEVDKAQLAAINKDVQANDTLFGKIIRKEIPAKIIFEDEEALAFHDVSPQAPVHFLVIPKRRINMLENAVDSDAALIGKLMVTAAKVAKQLNLADGYRVVVNNGKDGAQSVFHLHLHVLGGRQLTWPPG 155          
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A183PNH8 (HIT domain-containing protein OS=Schistosoma mattheei OX=31246 GN=SMTD_LOCUS15914 PE=4 SV=1)

HSP 1 Score: 187.963 bits (476), Expect = 2.515e-58
Identity = 86/129 (66.67%), Postives = 105/129 (81.40%), Query Frame = 1
Query:   82 SEVDKAKAA-CDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            SEV+KAK + C  G     TIF KIINK IPADI+YED+ CLAFRD+SPQAP HFLVIPKK+I  LDSA    E+LLGHLM++  +VA++E L++GYR+V+NNG DGAQSV+HLHLH++GGRQM WPPG
Sbjct:    3 SEVEKAKTSVCTQGP----TIFSKIINKEIPADIIYEDDDCLAFRDISPQAPTHFLVIPKKQIPTLDSASSEHEKLLGHLMLVCSQVAQKEGLTSGYRVVVNNGPDGAQSVYHLHLHVLGGRQMQWPPG 127          
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A430Q485 (Histidine triad (HIT) family protein OS=Schistosoma bovis OX=6184 GN=DC041_0003146 PE=4 SV=1)

HSP 1 Score: 186.422 bits (472), Expect = 8.475e-58
Identity = 85/129 (65.89%), Postives = 105/129 (81.40%), Query Frame = 1
Query:   82 SEVDKAKAA-CDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            SEV+KA+ + C  G     TIF KIINK IPADI+YED+ CLAFRD+SPQAP HFLVIPKK+I  LDSA    E+LLGHLM++  +VA++E L++GYR+V+NNG DGAQSV+HLHLH++GGRQM WPPG
Sbjct:    3 SEVEKARTSVCTQGP----TIFSKIINKEIPADIIYEDDDCLAFRDISPQAPTHFLVIPKKQIPTLDSASSEHEKLLGHLMLVCSQVAQKEGLASGYRVVVNNGPDGAQSVYHLHLHVLGGRQMQWPPG 127          
BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Match: A0A183JZT4 (HIT domain-containing protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS8242 PE=4 SV=1)

HSP 1 Score: 186.422 bits (472), Expect = 8.475e-58
Identity = 85/129 (65.89%), Postives = 105/129 (81.40%), Query Frame = 1
Query:   82 SEVDKAKAA-CDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            SEV+KA+ + C  G     TIF KIINK IPADI+YED+ CLAFRD+SPQAP HFLVIPKK+I  LDSA    E+LLGHLM++  +VA++E L++GYR+V+NNG DGAQSV+HLHLH++GGRQM WPPG
Sbjct:    3 SEVEKARTSVCTQGP----TIFSKIINKEIPADIIYEDDDCLAFRDISPQAPTHFLVIPKKQIPTLDSASSEHEKLLGHLMLVCSQVAQKEGLASGYRVVVNNGPDGAQSVYHLHLHVLGGRQMQWPPG 127          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Cavefish
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:NCBI gene;Acc:103038374])

HSP 1 Score: 171.785 bits (434), Expect = 2.446e-55
Identity = 78/128 (60.94%), Postives = 95/128 (74.22%), Query Frame = 1
Query:   82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
             EV KA+ A   GD    TIF KII K IPA I+YEDE C+AF DV+PQAP HFLV+P+K I  L  AED D  LLGHLMI+AK+ A+Q  L  GYR+V+N+G DG QSV+H+HLH++GGRQ+ WPPG
Sbjct:    3 EEVAKAQTAQPGGD----TIFGKIIRKEIPAKIIYEDEQCIAFHDVAPQAPTHFLVVPRKPIVQLSKAEDGDAALLGHLMIVAKKCAEQVGLPRGYRLVVNDGPDGGQSVYHVHLHVLGGRQLGWPPG 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Cavefish
Match: hint2 (uncharacterized HIT-like protein Synpcc7942_1390 [Source:NCBI gene;Acc:103043014])

HSP 1 Score: 168.318 bits (425), Expect = 1.787e-53
Identity = 74/127 (58.27%), Postives = 96/127 (75.59%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            EV  A+ A         TIF K+I+KTIPADI++ED  CLAFRD++PQAP+HFLVIP+  I  +  A D D  LLGHL+++AK +AK+E L  GYR+VIN+G +GAQSV+HLH+H++GGRQM WPPG
Sbjct:   39 EVRLAQEASKKYGNPAPTIFSKVIDKTIPADIIFEDYKCLAFRDINPQAPVHFLVIPRTPIPRISEAHDDDALLLGHLLVVAKNLAKKEGLDEGYRVVINDGKNGAQSVYHLHIHVLGGRQMQWPPG 165          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Cavefish
Match: hint3 (histidine triad nucleotide binding protein 3 [Source:NCBI gene;Acc:103030469])

HSP 1 Score: 67.3958 bits (163), Expect = 3.427e-14
Identity = 38/119 (31.93%), Postives = 60/119 (50.42%), Query Frame = 1
Query:   82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438
            +E D  +   DS DK    IF KI+N+ +  ++L+ DE    FRD+ P AP H+LV+P K +    S       L+  LM   K + ++ N+++   +          SV HLHLH++ 
Sbjct:   10 AEPDNKQQPSDSYDKK--CIFCKIVNREMDTELLHSDEEISCFRDIKPGAPHHYLVVPTKHVGNCKSLNKEHIPLVEKLMETGKTILQKNNVTDLNDVRFGFHWPPFHSVVHLHLHVLA 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002976.1 (pep scaffold:Pmarinus_7.0:GL478213:18376:23079:1 gene:ENSPMAG00000002715.1 transcript:ENSPMAT00000002976.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 175.637 bits (444), Expect = 5.904e-57
Identity = 81/130 (62.31%), Postives = 101/130 (77.69%), Query Frame = 1
Query:   85 EVDKAKAACDSGDK---TRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            EV +AK A    +K    + TIF KII++ IPADIL+ED+ CLAFRD+SPQAP HFLVIPK RI  +  A+  D QLLGHL+ IAK +AK+E L NGYR+VIN+G DG+QSV+HLH+H++GGRQM WPPG
Sbjct:   45 EVTRAKLAAQEWEKHGINKPTIFSKIISREIPADILHEDDMCLAFRDISPQAPTHFLVIPKLRIPRISQAQSQDTQLLGHLLFIAKTLAKKEGLDNGYRVVINDGPDGSQSVYHLHVHVIGGRQMLWPPG 174          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Sea Lamprey
Match: hint1 (histidine triad nucleotide binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-040927-8])

HSP 1 Score: 162.155 bits (409), Expect = 4.691e-52
Identity = 75/127 (59.06%), Postives = 95/127 (74.80%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            EV KA AA   GD    TIF KII K IPA+I++EDE C+ F DV+PQAP H LV+PKK I  L +A   D+ LLGHLM++A +VA Q  LS+GYR+V+N+G +G QSV+HLHLH++GGRQ+ WPPG
Sbjct:   24 EVAKALAARPGGD----TIFGKIIRKEIPANIIHEDEQCIVFHDVAPQAPTHLLVVPKKAIPGLPNATAEDQALLGHLMLVAAKVAAQVGLSSGYRLVLNDGPEGGQSVYHLHLHVLGGRQLGWPPG 146          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Yeast
Match: HNT1 (Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of histidine triad (HIT) superfamily of nucleotide-binding proteins; protein abundance increases in response to DNA replication stress; human homolog HINT1 can complement yeast hnt1 mutant [Source:SGD;Acc:S000002283])

HSP 1 Score: 61.2326 bits (147), Expect = 7.129e-13
Identity = 42/113 (37.17%), Postives = 56/113 (49.56%), Query Frame = 1
Query:  139 IFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQ------MTWP 459
            IF KII   IP+  L E +   AF D+ P A  H L+IPK     L    D  ++ L   M IAKR+AK   L + Y ++ NNG    Q V H+H H++  R       + WP
Sbjct:   26 IFCKIIKSEIPSFKLIETKYSYAFLDIQPTAEGHALIIPKYHGAKL---HDIPDEFLTDAMPIAKRLAKAMKL-DTYNVLQNNGKIAHQEVDHVHFHLIPKRDEKSGLIVGWP 134          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO31701 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX81])

HSP 1 Score: 162.925 bits (411), Expect = 1.949e-52
Identity = 74/111 (66.67%), Postives = 92/111 (82.88%), Query Frame = 1
Query:  136 TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSN-GYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            TIF KII K IPA+IL+ED+ CLAFRD++PQAP H LVIPKK I  L  A+DSDEQLLG L+I+A++VA  +NL+N GYRI+IN+G +G Q VFHLH+HI+GGR+M WPPG
Sbjct:    6 TIFGKIIRKEIPAEILHEDDQCLAFRDINPQAPTHVLVIPKKPIRQLSMADDSDEQLLGRLLIVARKVAAMQNLANDGYRIIINDGKNGGQEVFHLHVHILGGRKMKWPPG 116          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO45654 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSL2])

HSP 1 Score: 141.354 bits (355), Expect = 9.018e-44
Identity = 65/128 (50.78%), Postives = 94/128 (73.44%), Query Frame = 1
Query:   82 SEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLS-NGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPP 462
            SE +KA++A   GD    TIF +II   +PA  ++ED+ C+A  D++PQAP+HFLVIPK  I  L  A++ + +LLGH +++AK VAK + +S +G+R+VIN+G  G QSV+HLHLH++GGRQ+ WPP
Sbjct:    3 SEEEKAQSAVPGGD----TIFSRIIRGDVPATFIHEDDKCIAMDDINPQAPVHFLVIPKTPIQKLSLAQNWNAELLGHCLLVAKDVAKNKGISEDGFRVVINDGRHGCQSVYHLHLHVIGGRQLGWPP 126          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO37394 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFV5])

HSP 1 Score: 62.003 bits (149), Expect = 1.244e-12
Identity = 38/106 (35.85%), Postives = 55/106 (51.89%), Query Frame = 1
Query:  121 DKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438
            +K +  +F KI +K     I+YEDE  L F+D+ P    H+LVIPK+      S    D  L+  LM + K+V  Q+N +N    VI        S+ HLHLH++ 
Sbjct:    6 EKLKKCVFCKISSKEQETRIIYEDEETLTFKDLRPATDHHYLVIPKQHYGNPKSLTGDDLPLVEKLMDVGKKVLVQQN-ANTEDTVIGFHWPPFNSIQHLHLHVIS 110          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO26907 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7TAR3])

HSP 1 Score: 51.2174 bits (121), Expect = 4.241e-9
Identity = 30/70 (42.86%), Postives = 42/70 (60.00%), Query Frame = 1
Query:  136 TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAK 345
            +IF KIIN+ IP+  + ED++  AF D++P A  H LVIPKK +   D   D D +    L+  A +VAK
Sbjct:    3 SIFTKIINREIPSYKVAEDKNYYAFLDINPNAKGHTLVIPKKEV---DKLFDLDAETYTGLLQFAYKVAK 69          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Match: EDO32029 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWA8])

HSP 1 Score: 43.1282 bits (100), Expect = 9.610e-6
Identity = 34/104 (32.69%), Postives = 50/104 (48.08%), Query Frame = 1
Query:  142 FDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPK---KRITMLDSAEDSDEQLLGHLMIIAKRVA---KQENLSNGYRIVINNGSDGAQSVFHLHLHIM 435
            F  II K  P+ + Y     + F ++ P  P H LV P    KR   L   E SD      L I ++R+A   ++E  +    I I +G +  QSV H+H+HI+
Sbjct:   10 FGHIILK--PSVVFYRSNLSIGFVNIKPVLPGHVLVSPVRVVKRFVDLTQDEVSD------LFISSQRIAGVVEREFGATSLTISIQDGPEAGQSVQHVHVHIL 105          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: hint2 (histidine triad nucleotide-binding protein 2, mitochondrial [Source:NCBI gene;Acc:101167460])

HSP 1 Score: 177.948 bits (450), Expect = 3.931e-57
Identity = 75/110 (68.18%), Postives = 97/110 (88.18%), Query Frame = 1
Query:  136 TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            TIF K+I+K+IPADI+YED  CLAFRD+SPQAP+HFLVIP+  I  + +AED+D +LLGHL+++AK VAKQE+LS+GYR+VIN+G  GAQSV+HLH+H++GGRQM WPPG
Sbjct:   72 TIFSKVIDKSIPADIIYEDHMCLAFRDISPQAPVHFLVIPRTPIPRISAAEDADAELLGHLLVVAKNVAKQESLSDGYRVVINDGKHGAQSVYHLHVHVLGGRQMKWPPG 181          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: HINT1 (histidine triad nucleotide binding protein 1 [Source:NCBI gene;Acc:101161990])

HSP 1 Score: 162.155 bits (409), Expect = 3.349e-51
Identity = 72/127 (56.69%), Postives = 93/127 (73.23%), Query Frame = 1
Query:   85 EVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            E +KA+ A   GD    TIF KI+ K IP ++LYED+ C+AF D+SPQAP H LV+PKK I  L  AE+ D  LLGH++I+AK+ AK   L+ GYRIVIN+G DG QSV+H+H+H++GGR M WPPG
Sbjct:   35 ETEKAQTARPGGD----TIFGKIVRKEIPVNLLYEDDQCVAFPDISPQAPTHILVVPKKPIVQLSVAEEDDAALLGHMLIVAKKCAKDAGLTKGYRIVINDGPDGGQSVYHVHIHVLGGRMMGWPPG 157          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: hint3 (histidine triad nucleotide binding protein 3 [Source:ZFIN;Acc:ZDB-GENE-100922-168])

HSP 1 Score: 61.2326 bits (147), Expect = 5.067e-12
Identity = 30/103 (29.13%), Postives = 53/103 (51.46%), Query Frame = 1
Query:  130 RHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMG 438
            +  IF +I+N+ +  ++LY DE    FRD+ P AP H+LV+P + +    S       L+  L+ + K + ++ N+ +   +          SV HLHLH++ 
Sbjct:   19 KKCIFCRIVNREMGTELLYSDEEISCFRDIKPGAPHHYLVVPTQHVGNCKSLSKEHVPLVNRLVDVGKEILQKNNVMDLSDVRFGFHWPPFCSVTHLHLHVLA 121          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: ENSORLT00000036728.1 (histidine triad nucleotide-binding protein 3 [Source:NCBI gene;Acc:101174317])

HSP 1 Score: 50.447 bits (119), Expect = 7.700e-8
Identity = 27/95 (28.42%), Postives = 50/95 (52.63%), Query Frame = 1
Query:  172 ADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGG-RQMT 453
             +++ +D+  + FRD+ P AP H+LVIP+  I    S       L+  +  + K V +++ ++N   + +        SV HLHLH++   RQ++
Sbjct:   25 TEVIKQDKKLVCFRDIWPAAPHHYLVIPRAHIHSCRSLSGEHIHLVDRMTSMGKDVLREQGITNMEDVRLGFHQPPFISVGHLHLHVLAPVRQIS 119          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Match: aptx (aprataxin [Source:NCBI gene;Acc:101162025])

HSP 1 Score: 47.3654 bits (111), Expect = 1.929e-6
Identity = 28/91 (30.77%), Postives = 50/91 (54.95%), Query Frame = 1
Query:  169 PADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQ--ENLSNGYRIVINNGSDGAQSVFHLHLHIM 435
            P   +Y+D++ +  +D  P+A  H+LV+P + I  L + +     LL H+  +A+R+ KQ  E+ S  +R     G     S+ H+HLH++
Sbjct:  169 PKMQIYKDDTVVVIKDKYPKARYHWLVLPWQSIPSLKALKAEHCDLLKHMQKVAERMIKQCPESSSLSFR----TGYHAIPSMSHIHLHVI 255          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000067518.1 (SMESG000067518.1)

HSP 1 Score: 281.952 bits (720), Expect = 1.153e-98
Identity = 151/152 (99.34%), Postives = 151/152 (99.34%), Query Frame = 1
Query:   10 MYHXXXXXXXXXXXXXXXFFVRSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            MYHSISKIINSLSKSNIKFFVRSMSEVDKAKAACDSGDKTR TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG
Sbjct:    1 MYHSISKIINSLSKSNIKFFVRSMSEVDKAKAACDSGDKTRPTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 152          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000067518.1 (SMESG000067518.1)

HSP 1 Score: 266.929 bits (681), Expect = 3.653e-93
Identity = 128/129 (99.22%), Postives = 128/129 (99.22%), Query Frame = 1
Query:   79 MSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            MSEVDKAKAACDSGDKTR TIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG
Sbjct:    1 MSEVDKAKAACDSGDKTRPTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 129          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000060398.1 (SMESG000060398.1)

HSP 1 Score: 224.172 bits (570), Expect = 4.392e-76
Identity = 128/152 (84.21%), Postives = 131/152 (86.18%), Query Frame = 1
Query:   10 MYHXXXXXXXXXXXXXXXFFVRSMSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            MYHSISKIINSLSKSNI+FFVRSMSEVDKAKAACDSGDKTR TIFDKIINKTIPADILYEDE+   F                + ITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG
Sbjct:    1 MYHSISKIINSLSKSNIQFFVRSMSEVDKAKAACDSGDKTRPTIFDKIINKTIPADILYEDEAVWLF----------------EIITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 136          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000060398.1 (SMESG000060398.1)

HSP 1 Score: 209.92 bits (533), Expect = 1.050e-70
Identity = 106/129 (82.17%), Postives = 108/129 (83.72%), Query Frame = 1
Query:   79 MSEVDKAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            MSEVDKAKAACDSGDKTR TIFDKIINKTIPADILYEDE+   F                + ITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG
Sbjct:    1 MSEVDKAKAACDSGDKTRPTIFDKIINKTIPADILYEDEAVWLF----------------EIITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 113          
BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Match: SMESG000004839.1 (SMESG000004839.1)

HSP 1 Score: 140.198 bits (352), Expect = 9.285e-43
Identity = 58/124 (46.77%), Postives = 88/124 (70.97%), Query Frame = 1
Query:   94 KAKAACDSGDKTRHTIFDKIINKTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLLGHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWPPG 465
            K+   C    K+  ++F KIIN+ +PA ILYED+ C+AF  +S    + FLV+P K+I  L+ A++ D  LLGHLM++A ++A+++  +NGYR+VINNG D  Q V HLH+H+ GG++++WPPG
Sbjct:   23 KSFQQCKFQAKSEPSVFTKIINRELPATILYEDDKCIAFLSLSRPTKVKFLVVPLKQIATLEEAQECDANLLGHLMLVASKIAREQGANNGYRLVINNGPDALQDVPHLHIHVYGGQKLSWPPG 146          
The following BLAST results are available for this feature:
BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HINT22.750e-5659.09histidine triad nucleotide binding protein 2 [Sour... [more]
HINT16.682e-5461.42histidine triad nucleotide binding protein 1 [Sour... [more]
HINT14.814e-2356.96histidine triad nucleotide binding protein 1 [Sour... [more]
HINT18.715e-2258.11histidine triad nucleotide binding protein 1 [Sour... [more]
HINT18.818e-2257.33histidine triad nucleotide binding protein 1 [Sour... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
hint-14.523e-5964.62Histidine triad nucleotide-binding protein 1 [Sou... [more]
hint-14.523e-5964.62Histidine triad nucleotide-binding protein 1 [Sou... [more]
nft-12.091e-733.62Nitrilase and fragile histidine triad fusion prote... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
CG28621.302e-5358.78gene:FBgn0031459 transcript:FBtr0335128[more]
CG28621.302e-5358.78gene:FBgn0031459 transcript:FBtr0077718[more]
CG28623.110e-5359.38gene:FBgn0031459 transcript:FBtr0077719[more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hint16.654e-5456.69histidine triad nucleotide binding protein 1 [Sour... [more]
hint16.654e-5456.69histidine triad nucleotide binding protein 1 [Sour... [more]
hint27.938e-5458.27histidine triad nucleotide binding protein 2 [Sour... [more]
si:dkey-25e12.38.043e-1035.96si:dkey-25e12.3 [Source:NCBI gene;Acc:678527][more]
si:dkey-25e12.39.098e-1035.96si:dkey-25e12.3 [Source:NCBI gene;Acc:678527][more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 3
Match NameE-valueIdentityDescription
hint15.560e-5660.63histidine triad nucleotide binding protein 1 [Sour... [more]
sirt3.21.752e-2846.90sirtuin (silent mating type information regulation... [more]
cks21.420e-828.71CDC28 protein kinase regulatory subunit 2 [Source:... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Hint29.822e-5657.03histidine triad nucleotide binding protein 2 [Sour... [more]
Hint13.621e-5359.84histidine triad nucleotide binding protein 1 [Sour... [more]
Hint16.967e-2153.75histidine triad nucleotide binding protein 1 [Sour... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P53795|HINT_CAEEL5.753e-5864.62Histidine triad nucleotide-binding protein 1 OS=Ca... [more]
sp|Q9BX68|HINT2_HUMAN1.321e-5559.09Histidine triad nucleotide-binding protein 2, mito... [more]
sp|Q9D0S9|HINT2_MOUSE6.870e-5557.03Histidine triad nucleotide-binding protein 2, mito... [more]
sp|P62958|HINT1_BOVIN1.247e-5462.20Histidine triad nucleotide-binding protein 1 OS=Bo... [more]
sp|P80912|HINT1_RABIT2.063e-5461.42Histidine triad nucleotide-binding protein 1 OS=Or... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A183B3962.498e-6267.97HIT domain-containing protein OS=Echinostoma capro... [more]
A0A2H2HW244.644e-5965.91HIT domain-containing protein OS=Caenorhabditis ja... [more]
A0A183PNH82.515e-5866.67HIT domain-containing protein OS=Schistosoma matth... [more]
A0A430Q4858.475e-5865.89Histidine triad (HIT) family protein OS=Schistosom... [more]
A0A183JZT48.475e-5865.89HIT domain-containing protein OS=Schistosoma curas... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
HINT12.446e-5560.94histidine triad nucleotide binding protein 1 [Sour... [more]
hint21.787e-5358.27uncharacterized HIT-like protein Synpcc7942_1390 [... [more]
hint33.427e-1431.93histidine triad nucleotide binding protein 3 [Sour... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ENSPMAT00000002976.15.904e-5762.31pep scaffold:Pmarinus_7.0:GL478213:18376:23079:1 g... [more]
hint14.691e-5259.06histidine triad nucleotide binding protein 1 [Sour... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
HNT17.129e-1337.17Adenosine 5'-monophosphoramidase; interacts physic... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO317011.949e-5266.67Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO456549.018e-4450.78Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO373941.244e-1235.85Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO269074.241e-942.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO320299.610e-632.69Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hint23.931e-5768.18histidine triad nucleotide-binding protein 2, mito... [more]
HINT13.349e-5156.69histidine triad nucleotide binding protein 1 [Sour... [more]
hint35.067e-1229.13histidine triad nucleotide binding protein 3 [Sour... [more]
ENSORLT00000036728.17.700e-828.42histidine triad nucleotide-binding protein 3 [Sour... [more]
aptx1.929e-630.77aprataxin [Source:NCBI gene;Acc:101162025][more]
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BLAST of Histidine triad nucleotide-binding protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000067518.11.153e-9899.34SMESG000067518.1[more]
SMESG000067518.13.653e-9399.22SMESG000067518.1[more]
SMESG000060398.14.392e-7684.21SMESG000060398.1[more]
SMESG000060398.11.050e-7082.17SMESG000060398.1[more]
SMESG000004839.19.285e-4346.77SMESG000004839.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30030230 ID=SMED30030230|Name=Histidine triad nucleotide-binding protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=534bp
TTTTAATTTATGTATCACAGCATTTCAAAAATTATTAATTCTTTAAGTAA
AAGTAACATTAAATTTTTCGTTCGTTCAATGTCAGAAGTTGATAAAGCTA
AAGCTGCTTGTGATTCTGGTGATAAAACACGTCATACAATTTTTGATAAA
ATTATCAACAAAACAATACCGGCTGATATTCTTTATGAAGATGAAAGCTG
TTTGGCTTTTCGAGATGTGTCCCCTCAAGCTCCTATTCATTTTTTGGTTA
TTCCTAAAAAAAGAATTACTATGTTAGATAGCGCTGAGGATTCTGATGAG
CAACTTTTAGGACATCTTATGATTATAGCTAAAAGGGTAGCAAAGCAAGA
AAATTTAAGCAACGGTTACAGAATAGTTATCAATAATGGATCTGATGGAG
CTCAATCTGTTTTTCACTTACATTTACATATAATGGGAGGTCGACAAATG
ACATGGCCACCAGGATAGAAATTGTTTATAAAATTTAAATAAATACAAAA
ATGGTTTTTGTTTTTAAAAAAAAAGATCGGAAGA
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protein sequence of SMED30030230-orf-1

>SMED30030230-orf-1 ID=SMED30030230-orf-1|Name=SMED30030230-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=153bp
MYHSISKIINSLSKSNIKFFVRSMSEVDKAKAACDSGDKTRHTIFDKIIN
KTIPADILYEDESCLAFRDVSPQAPIHFLVIPKKRITMLDSAEDSDEQLL
GHLMIIAKRVAKQENLSNGYRIVINNGSDGAQSVFHLHLHIMGGRQMTWP
PG*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR036265HIT-like_sf
IPR001310Histidine_triad_HIT
IPR011146HIT-like
IPR019808Histidine_triad_CS
Vocabulary: molecular function
TermDefinition
GO:0003824catalytic activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001310Histidine triad (HIT) proteinPRINTSPR00332HISTRIADcoord: 65..83
score: 65.05
coord: 44..60
score: 53.65
coord: 132..142
score: 63.27
IPR001310Histidine triad (HIT) proteinPFAMPF01230HITcoord: 51..146
e-value: 8.4E-30
score: 103.4
IPR036265HIT-like superfamilyGENE3DG3DSA:3.30.428.10coord: 23..152
e-value: 3.1E-43
score: 149.0
IPR036265HIT-like superfamilySUPERFAMILYSSF54197HIT-likecoord: 42..151
NoneNo IPR availablePANTHERPTHR23089HISTIDINE TRIAD HIT PROTEINcoord: 9..152
NoneNo IPR availablePANTHERPTHR23089:SF18HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN 2, MITOCHONDRIALcoord: 9..152
NoneNo IPR availableCDDcd01276PKCI_relatedcoord: 42..144
e-value: 1.64023E-56
score: 170.05
IPR019808Histidine triad, conserved sitePROSITEPS00892HIT_1coord: 125..143
IPR011146HIT-like domainPROSITEPS51084HIT_2coord: 44..152
score: 16.384