Lamin-B receptor

Overview


Name	Lamin-B receptor
Smed ID	SMED30030198
Length (bp)	1808

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Lamin-B receptor (SMED30030198) t-SNE clustered cells

Violin plots show distribution of expression levels for Lamin-B receptor (SMED30030198) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Lamin-B receptor (SMED30030198) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Lamin-B receptor (SMED30030198) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30030198

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 15

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30030198	SMESG000042131.1	SmedASXL_019163	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30030198	SMESG000042131.1	SmedASXL_019163	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
protonephridia	SMED30030198	SMESG000042131.1	dd_Smed_v4_2016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30030198	SMESG000042131.1	dd_Smed_v4_2016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30030198	SMESG000042131.1	dd_Smed_v4_2016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30030198	SMESG000042131.1	dd_Smed_v4_2016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30030198	SMESG000042131.1	dd_Smed_v4_2016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30030198	SMESG000042131.1	dd_Smed_v4_2016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30030198	SMESG000042131.1	dd_Smed_v4_2016_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30030198	SMESG000042131.1	Contig51198	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
parenchyma	SMED30030198	SMESG000042131.1	Contig51198	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016
gut	SMED30030198	SMESG000042131.1	SMED30030198	smed_20140614	PMID:26457503 Tu et al., 2015
parenchyma	SMED30030198	SMESG000042131.1	SMED30030198	smed_20140614	PMID:26457503 Tu et al., 2015
neoblast	SMED30030198	SMESG000042131.1	SMED_02186_V2_1	GPL14150_gene_models	PMID:22385657 Wagner et al., 2012
neoblast	SMED30030198	SMESG000042131.1	SMED_02186_V2_1	GPL14150	PMID:22385657 Wagner et al., 2012

Note: Hover over icons to view figure legend

Homology

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BLAST of Lamin-B receptor vs. Ensembl Human
Match: LBR (lamin B receptor [Source:HGNC Symbol;Acc:HGNC:6518])

HSP 1 Score: 216.853 bits (551), Expect = 8.873e-62
Identity = 117/359 (32.59%), Postives = 199/359 (55.43%), Query Frame = 3

Query:  564 GIVICWLMYLAALAHIPIGKTAYSTTK-KGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA-FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAI--QINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            G+ + W +       +PIGK    T    G  +KYR NG  + I+T +++ G    + +    VY ++     ++ +  VV    L ++S    +  ++     N +Y+F +GRE+N R    DLK+F E RPG  GW+++N++  L +++ ++    + +++     Q++Y +DA+  E  +++   +++  FGF    G+ V VPF+++     +    N    P+  L  I V+ L GY+I+R +N QKN+FR+NP    L HLKTI    G  +LV GWWG +RHPNY GD+I+ L+WSL  G N  + +FY IYF + ++ R  +D+  C  ++G AW  Y + VPYR+ P+++
Sbjct:  260 GVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILT-SAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASL--IIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 615

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Query:  564 GIVICWLMYLAALAHIPIGKTAYSTTK-KGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA-FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAI--QINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            G+ + W +       +PIGK    T    G  +KYR NG  + I+T +++ G    + +    VY ++     ++ +  VV    L ++S    +  ++     N +Y+F +GRE+N R    DLK+F E RPG  GW+++N++  L +++ ++    + +++     Q++Y +DA+  E  +++   +++  FGF    G+ V VPF+++     +    N    P+  L  I V+ L GY+I+R +N QKN+FR+NP    L HLKTI    G  +LV GWWG +RHPNY GD+I+ L+WSL  G N  + +FY IYF + ++ R  +D+  C  ++G AW  Y + VPYR+ P+++
Sbjct:  260 GVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILT-SAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASL--IIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 615

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BLAST of Lamin-B receptor vs. Ensembl Human
Match: TM7SF2 (transmembrane 7 superfamily member 2 [Source:HGNC Symbol;Acc:HGNC:11863])

HSP 1 Score: 198.749 bits (504), Expect = 7.544e-57
Identity = 92/253 (36.36%), Postives = 155/253 (61.26%), Query Frame = 3

Query:  870 NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            N IY+F +GRE+N R    D K+F E RPG  GW+++N+   +K+ E R   S+  ++      Q++Y  DA+  E  +++   + +  FGF    G+   VPF ++L  + +  +   L +   + I +IN  GY I+R +N QKN+FR+NP    +  L+TI+   G ++LV GWWG++RHPNY GD+I+ L+WSL  G++  + +FY +YF   ++ R  +D+R+C  ++G AW +Y + VPYR++P+++
Sbjct:  168 NPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSL--AMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY 418

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BLAST of Lamin-B receptor vs. Ensembl Human
Match: TM7SF2 (transmembrane 7 superfamily member 2 [Source:HGNC Symbol;Acc:HGNC:11863])

HSP 1 Score: 153.68 bits (387), Expect = 6.974e-42
Identity = 74/198 (37.37%), Postives = 118/198 (59.60%), Query Frame = 3

Query:  870 NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSL 1463
            N IY+F +GRE+N R    D K+F E RPG  GW+++N+   +K+ E R   S+  ++      Q++Y  DA+  E  +++   + +  FGF    G+   VPF ++L  + +  +   L +   + I +IN  GY I+R +N QKN+FR+NP    +  L+TI+   G ++LV GWWG++RHPNY GD+I+ L+WSL
Sbjct:   74 NPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSL--AMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSDPRVAGLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSL 269

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BLAST of Lamin-B receptor vs. Ensembl Human
Match: TM7SF2 (transmembrane 7 superfamily member 2 [Source:HGNC Symbol;Acc:HGNC:11863])

HSP 1 Score: 156.762 bits (395), Expect = 9.700e-42
Identity = 80/253 (31.62%), Postives = 138/253 (54.55%), Query Frame = 3

Query:  870 NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            N IY+F +GRE+N R    D K+F E RPG  GW+++N+   +K+ E R   S+  ++      Q++Y  DA+  E  +++   + +  FGF    G+   VPF ++L  + +  +   L +   + I +IN                            L+TI+   G ++LV GWWG++RHPNY GD+I+ L+WSL  G++  + +FY +YF   ++ R  +D+R+C  ++G AW +Y + VPYR++P+++
Sbjct:  168 NPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSL--AMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLIN---------------------------GLETISTATGRKLLVSGWWGMVRHPNYLGDLIMALAWSLPCGVSHLLPYFYLLYFTALLVHREARDERQCLQKYGLAWQEYCRRVPYRIMPYIY 391

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BLAST of Lamin-B receptor vs. Ensembl Celegans
Match: dhcr-7 (DeHydroCholesterol Reductase; Sterol reductase [Source:UniProtKB/TrEMBL;Acc:G5ED82])

HSP 1 Score: 69.3218 bits (168), Expect = 3.429e-12
Identity = 56/264 (21.21%), Postives = 108/264 (40.91%), Query Frame = 3

Query:  867 INFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHL---------CHLKTITNRHGHQILVG-GWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            +  I  F  G E + +   +DLK F   R  F  W +   +          +  I+ SL+  +  Q++Y       E   ++        FGF+    + V+ P ++T     +   N  + +        + +   +     + QK  FR++  ++ +            +T +      +L+G G WG+ RHPNY  + I   ++S + G    +     ++ +LF++ R   D+ +C +++G  W  Y   V YR +P VF
Sbjct:  196 VTTISEFWFGIENHPKILDIDLKSFIRTRFTFVIWPLF--VISAMYFHKITYGQISTSLVCLSSVQLLYIFQFHWNEDLFLNSLDSKRCDFGFYRIWADFVLGPIIYTSPVTILVATNRSVGVISNCLFCAVAIGSMVFTAKCDRQKYEFRKSKGTLKVGGVDAFFISAKYRTDSGDANTNLLLGSGHWGVCRHPNYASEAITFAAFSAFQGFPSTIAHIPSLFVILFLVARAFTDENRCLIKYGQYWAQYCSKVKYRFLPGVF 457

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Query:  867 INFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHL---------CHLKTITNRHGHQILVG-GWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            +  I  F  G E + +   +DLK F   R  F  W +   +          +  I+ SL+  +  Q++Y       E   ++        FGF+    + V+ P ++T     +   N  + +        + +   +     + QK  FR++  ++ +            +T +      +L+G G WG+ RHPNY  + I   ++S + G    +     ++ +LF++ R   D+ +C +++G  W  Y   V YR +P VF
Sbjct:  196 VTTISEFWFGIENHPKILDIDLKSFIRTRFTFVIWPLF--VISAMYFHKITYGQISTSLVCLSSVQLLYIFQFHWNEDLFLNSLDSKRCDFGFYRIWADFVLGPIIYTSPVTILVATNRSVGVISNCLFCAVAIGSMVFTAKCDRQKYEFRKSKGTLKVGGVDAFFISAKYRTDSGDANTNLLLGSGHWGVCRHPNYASEAITFAAFSAFQGFPSTIAHIPSLFVILFLVARAFTDENRCLIKYGQYWAQYCSKVKYRFLPGVF 457

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BLAST of Lamin-B receptor vs. Ensembl Fly
Match: LBR (gene:FBgn0034657 transcript:FBtr0071712)

HSP 1 Score: 69.707 bits (169), Expect = 4.740e-12
Identity = 60/217 (27.65%), Postives = 104/217 (47.93%), Query Frame = 3

Query:  861 RPINFIYNFIVGREINTRFFG-LDLKFFYEFRPGFTGWMILNIIFCLK--------DLEDRE---------FKSINY--SLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKC-LASIAVINLI--GYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDII 1442
            R  +F+ +F +GR++N ++ G +D K F ++R      +I    +  +         L ++E         + ++NY  + LF A   + Y LDA++FE  + S   + +  +G    L      P+L T  T+       ++PI C  A +AV  L+  G ++ R S   K  +R N  S    +++TI    G ++L+ G WG +R PNY GDI+
Sbjct:  441 RTGSFVVDFALGRQLNPKWLGRVDWKQF-QYRLSLVTTLIYATCYIYQTLVWPQKPQLGEQEGYLYQAKYYWNNVNYDPATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RYAATPYLLTAVTKYFYEQ--RVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHTYQGSRLLLSGMWGWVRQPNYLGDIV 653

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BLAST of Lamin-B receptor vs. Ensembl Fly
Match: LBR (gene:FBgn0034657 transcript:FBtr0071711)

HSP 1 Score: 69.707 bits (169), Expect = 4.740e-12
Identity = 60/217 (27.65%), Postives = 104/217 (47.93%), Query Frame = 3

Query:  861 RPINFIYNFIVGREINTRFFG-LDLKFFYEFRPGFTGWMILNIIFCLK--------DLEDRE---------FKSINY--SLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKC-LASIAVINLI--GYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDII 1442
            R  +F+ +F +GR++N ++ G +D K F ++R      +I    +  +         L ++E         + ++NY  + LF A   + Y LDA++FE  + S   + +  +G    L      P+L T  T+       ++PI C  A +AV  L+  G ++ R S   K  +R N  S    +++TI    G ++L+ G WG +R PNY GDI+
Sbjct:  441 RTGSFVVDFALGRQLNPKWLGRVDWKQF-QYRLSLVTTLIYATCYIYQTLVWPQKPQLGEQEGYLYQAKYYWNNVNYDPATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RYAATPYLLTAVTKYFYEQ--RVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHTYQGSRLLLSGMWGWVRQPNYLGDIV 653

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BLAST of Lamin-B receptor vs. Ensembl Fly
Match: LBR (gene:FBgn0034657 transcript:FBtr0071713)

HSP 1 Score: 69.707 bits (169), Expect = 5.053e-12
Identity = 60/217 (27.65%), Postives = 104/217 (47.93%), Query Frame = 3

Query:  861 RPINFIYNFIVGREINTRFFG-LDLKFFYEFRPGFTGWMILNIIFCLK--------DLEDRE---------FKSINY--SLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKC-LASIAVINLI--GYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDII 1442
            R  +F+ +F +GR++N ++ G +D K F ++R      +I    +  +         L ++E         + ++NY  + LF A   + Y LDA++FE  + S   + +  +G    L      P+L T  T+       ++PI C  A +AV  L+  G ++ R S   K  +R N  S    +++TI    G ++L+ G WG +R PNY GDI+
Sbjct:  466 RTGSFVVDFALGRQLNPKWLGRVDWKQF-QYRLSLVTTLIYATCYIYQTLVWPQKPQLGEQEGYLYQAKYYWNNVNYDPATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RYAATPYLLTAVTKYFYEQ--RVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHTYQGSRLLLSGMWGWVRQPNYLGDIV 678

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BLAST of Lamin-B receptor vs. Ensembl Zebrafish
Match: lbr (lamin B receptor [Source:ZFIN;Acc:ZDB-GENE-030804-11])

HSP 1 Score: 228.794 bits (582), Expect = 2.200e-66
Identity = 138/463 (29.81%), Postives = 243/463 (52.48%), Query Frame = 3

Query:  249 RRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKVKVLSKFQIYFKSMKSIMFCCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAFRPIN--FIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            RR  Q + K +  +  +E E + ++K P  +   + E                F     ++F  M    +  + LL    +  A ++    +   LQ   D +  GIV+ WL++ A L+ +P+GK       K G  +KYR NG  ++++T  + AG+   + +    ++ ++     S++L+A +    L ++S    K ++A    +   IY+F +GRE+N R    D+KFF E RPG  GW+++N    L +++ +  ++ + ++L   I Q+++ +D +  E  +++   ++   FGF    G+   VPF FT     +  +  +L +  + ++  +N +GY I+R +N QK +FR+NP    + HLKTI    G  ++V G WG +RHPNY GDII+ L+WSL  G N  V +FY IY +  ++ R  +D+R+C  ++G+AW +Y KAVPYR+ P V+
Sbjct:  175 RRKDQGDGKAVELEKAVESEPLLQTKAPAAVKTADLE----------------FGGRVGVLFL-MFLLPVAVLVLLILCGQKDASLQSFPLELPALQSVWDCQVFGIVLLWLLFQAFLSLLPVGKLVEGMPLKNGKTLKYRINGFYALLLTAVA-AGVAVYQEVDLSYIHAHFLQFYTSALLIATLLSIYLFIRSRWASKDELAPGGNSGYIIYDFFMGRELNPRIKSFDIKFFCEMRPGLMGWVLINFAMLLAEMKQQNLENPSPAMLLVNIFQLLWVIDGLWHEEKLLTMMDIMYDGFGFMLTFGDLAFVPFTFTCQAYYLVNHPNELSVFWIITLIAMNGVGYYIFRKANSQKFAFRKNPSDPAVSHLKTIPTATGKSLIVSGLWGFVRHPNYLGDIIMALAWSLPCGFNNLVPYFYLIYLVTLLVHRNARDERQCRKKYGSAWEEYCKAVPYRIFPRVY 619

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Query:  249 RRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKVKVLSKFQIYFKSMKSIMFCCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAFRPIN--FIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            RR  Q + K +  +  +E E + ++K P  +   + E                F     ++F  M    +  + LL    +  A ++    +   LQ   D +  GIV+ WL++ A L+ +P+GK       K G  +KYR NG  ++++T  + AG+   + +    ++ ++     S++L+A +    L ++S    K ++A    +   IY+F +GRE+N R    D+KFF E RPG  GW+++N    L +++ +  ++ + ++L   I Q+++ +D +  E  +++   ++   FGF    G+   VPF FT     +  +  +L +  + ++  +N +GY I+R +N QK +FR+NP    + HLKTI    G  ++V G WG +RHPNY GDII+ L+WSL  G N  V +FY IY +  ++ R  +D+R+C  ++G+AW +Y KAVPYR+ P V+
Sbjct:  175 RRKDQGDGKAVELEKAVESEPLLQTKAPAAVKTADLE----------------FGGRVGVLFL-MFLLPVAVLVLLILCGQKDASLQSFPLELPALQSVWDCQVFGIVLLWLLFQAFLSLLPVGKLVEGMPLKNGKTLKYRINGFYALLLTAVA-AGVAVYQEVDLSYIHAHFLQFYTSALLIATLLSIYLFIRSRWASKDELAPGGNSGYIIYDFFMGRELNPRIKSFDIKFFCEMRPGLMGWVLINFAMLLAEMKQQNLENPSPAMLLVNIFQLLWVIDGLWHEEKLLTMMDIMYDGFGFMLTFGDLAFVPFTFTCQAYYLVNHPNELSVFWIITLIAMNGVGYYIFRKANSQKFAFRKNPSDPAVSHLKTIPTATGKSLIVSGLWGFVRHPNYLGDIIMALAWSLPCGFNNLVPYFYLIYLVTLLVHRNARDERQCRKKYGSAWEEYCKAVPYRIFPRVY 619

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BLAST of Lamin-B receptor vs. Ensembl Zebrafish
Match: tm7sf2 (transmembrane 7 superfamily member 2 [Source:ZFIN;Acc:ZDB-GENE-041212-19])

HSP 1 Score: 207.994 bits (528), Expect = 1.525e-60
Identity = 122/401 (30.42%), Postives = 214/401 (53.37%), Query Frame = 3

Query:  435 CCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEK--IKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            C  VF  +  ++LL+      A +           +  D     ++  W+   + L  +PIGK +     + G  +KY  NG  ++ IT   L  +     +    +++    L   +I V+ +    L ++S+   +  + +     N +Y+F +GRE+N R    DLK+F E RPG  GW+++N+   +K++E R+  S+  ++L     Q++Y  DA+  E  +++   +++  FGF    G+   VPF ++L    + ++   L       I ++N IGY I+R SN QKN FR++P    + HL+TI    G ++LV GWWG +RHPNY GD+++ L+WSL  G++  + +FY IYF + +I R  +D+++C  ++G AW+ Y + VPYR+IP+V+
Sbjct:   24 CIPVFLPLTVLYLLSVCRSPAASVLQWPPPLPPATHLWDPWAAVLIAGWIALQSFLYLLPIGKVSEGLVLRDGSRLKYPINGFHALSITAVLLI-ICILLGMPLGHLFELILPLAICAIGVSYLLSMYLYIRSFWAHQHALSLGGNTGNPLYDFFMGRELNPRIGNFDLKYFCELRPGLIGWVVINLGMLMKEVELRDSPSL--AMLLVNGFQLLYVTDALWNEEAVLTTMDIVHDGFGFMLAFGDLAWVPFTYSLQAMFLVVHPQSLSTLGAVGIVLLNGIGYYIFRRSNSQKNQFRRDPKHKSVAHLETIATATGKRLLVSGWWGFVRHPNYLGDLLMALAWSLPCGISHILPYFYVIYFTILLIHREARDEKQCRAKYGVAWDTYCRRVPYRIIPYVY 421

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Query:  435 CCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEK--IKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            C  VF  +  ++LL+      A +           +  D     ++  W+   + L  +PIGK +     + G  +KY  NG  ++ IT   L  +     +    +++    L   +I V+ +    L ++S+   +  + +     N +Y+F +GRE+N R    DLK+F E RPG  GW+++N+   +K++E R+  S+  ++L     Q++Y  DA+  E  +++   +++  FGF    G+   VPF ++L    + ++   L       I ++N IGY I+R SN QKN FR++P    + HL+TI    G ++LV GWWG +RHPNY GD+++ L+WSL  G++  + +FY IYF + +I R  +D+++C  ++G AW+ Y + VPYR+IP+V+
Sbjct:   24 CIPVFLPLTVLYLLSVCRSPAASVLQWPPPLPPATHLWDPWAAVLIAGWIALQSFLYLLPIGKVSEGLVLRDGSRLKYPINGFHALSITAVLLI-ICILLGMPLGHLFELILPLAICAIGVSYLLSMYLYIRSFWAHQHALSLGGNTGNPLYDFFMGRELNPRIGNFDLKYFCELRPGLIGWVVINLGMLMKEVELRDSPSL--AMLLVNGFQLLYVTDALWNEEAVLTTMDIVHDGFGFMLAFGDLAWVPFTYSLQAMFLVVHPQSLSTLGAVGIVLLNGIGYYIFRRSNSQKNQFRRDPKHKSVAHLETIATATGKRLLVSGWWGFVRHPNYLGDLLMALAWSLPCGISHILPYFYVIYFTILLIHREARDEKQCRAKYGVAWDTYCRRVPYRIIPYVY 421

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Query:  435 CCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEK--IKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            C  VF  +  ++LL+      A +           +  D     ++  W+   + L  +PIGK +     + G  +KY  NG  ++ IT   L  +     +    +++    L   +I V+ +    L ++S+   +  + +     N +Y+F +GRE+N R    DLK+F E RPG  GW+++N+   +K++E R+  S+  ++L     Q++Y  DA+  E  +++   +++  FGF    G+   VPF ++L    + ++   L       I ++N IGY I+R SN QKN FR++P    + HL+TI    G ++LV GWWG +RHPNY GD+++ L+WSL  G++  + +FY IYF + +I R  +D+++C  ++G AW+ Y + VPYR+IP+V+
Sbjct:   24 CIPVFLPLTVLYLLSVCRSPAASVLQWPPPLPPATHLWDPWAAVLIAGWIALQSFLYLLPIGKVSEGLVLRDGSRLKYPINGFHALSITAVLLI-ICILLGMPLGHLFELILPLAICAIGVSYLLSMYLYIRSFWAHQHALSLGGNTGNPLYDFFMGRELNPRIGNFDLKYFCELRPGLIGWVVINLGMLMKEVELRDSPSL--AMLLVNGFQLLYVTDALWNEEAVLTTMDIVHDGFGFMLAFGDLAWVPFTYSLQAMFLVVHPQSLSTLGAVGIVLLNGIGYYIFRRSNSQKNQFRRDPKHKSVAHLETIATATGKRLLVSGWWGFVRHPNYLGDLLMALAWSLPCGISHILPYFYVIYFTILLIHREARDEKQCRAKYGVAWDTYCRRVPYRIIPYVY 421

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BLAST of Lamin-B receptor vs. Ensembl Xenopus
Match: rp9 (retinitis pigmentosa 9 (autosomal dominant) [Source:Xenbase;Acc:XB-GENE-944905])

HSP 1 Score: 228.024 bits (580), Expect = 8.956e-68
Identity = 132/392 (33.67%), Postives = 219/392 (55.87%), Query Frame = 3

Query:  465 VFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGK-TAYSTTKKGIEVKYRFNGVISMIITITSLAG-LMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA--FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            ++LL   S + A +  +      L    D   + +++ W+   A L  +PIGK T   T +    +KYR N + +M++T    AG +M+   L+   VYD++  +   +  +A++    L  KS    +  +A      N +Y+F +G E+N R    DLK+F E RPG  GW ++N+ F +KD+E R   S++  L+F    Q +Y +DA+  E  I++   +++  FGF    G+   VPF ++L    +  +  +L       I ++N +GYII+R SN QKN+FR+NP    +  L+TI    G ++LV GWWGL+RHPNY GD+I+ L+WSL  GL+  + +FY IYF + ++ R  +D+ +C  ++G AW +Y + VPYR+ P+++
Sbjct:   44 LYLLVTCSTEDASVLRVPGPWPALDTLWDPFAVILLLSWVSLQAVLYMLPIGKVTEGITLRDNTRLKYRINALQAMMVTALIAAGAVMFGFPLS--YVYDHFLQMAVGAAFIALILSIFLYAKSLAAPQSALAPGGNSGNPLYDFFIGHELNPRIGSFDLKYFCELRPGLIGWCLINLCFLMKDIELRGSPSLSMILVFG--FQALYVVDAMKHEEAILTTMDIVHDGFGFMLAFGDLCWVPFTYSLQGYFLVRHPQELSTYAAVGIILLNAVGYIIFRGSNSQKNAFRRNPADPKVVGLETIPTATGKRLLVSGWWGLVRHPNYLGDLIMALAWSLPCGLSNILPYFYVIYFTVLLVHREARDEHQCMKKYGVAWQEYCRRVPYRIFPYIY 431

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BLAST of Lamin-B receptor vs. Ensembl Xenopus
Match: rp9 (retinitis pigmentosa 9 (autosomal dominant) [Source:Xenbase;Acc:XB-GENE-944905])

HSP 1 Score: 226.868 bits (577), Expect = 1.427e-67
Identity = 132/392 (33.67%), Postives = 219/392 (55.87%), Query Frame = 3

Query:  465 VFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGK-TAYSTTKKGIEVKYRFNGVISMIITITSLAG-LMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA--FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            ++LL   S + A +  +      L    D   + +++ W+   A L  +PIGK T   T +    +KYR N + +M++T    AG +M+   L+   VYD++  +   +  +A++    L  KS    +  +A      N +Y+F +G E+N R    DLK+F E RPG  GW ++N+ F +KD+E R   S++  L+F    Q +Y +DA+  E  I++   +++  FGF    G+   VPF ++L    +  +  +L       I ++N +GYII+R SN QKN+FR+NP    +  L+TI    G ++LV GWWGL+RHPNY GD+I+ L+WSL  GL+  + +FY IYF + ++ R  +D+ +C  ++G AW +Y + VPYR+ P+++
Sbjct:   26 LYLLVTCSTEDASVLRVPGPWPALDTLWDPFAVILLLSWVSLQAVLYMLPIGKVTEGITLRDNTRLKYRINALQAMMVTALIAAGAVMFGFPLS--YVYDHFLQMAVGAAFIALILSIFLYAKSLAAPQSALAPGGNSGNPLYDFFIGHELNPRIGSFDLKYFCELRPGLIGWCLINLCFLMKDIELRGSPSLSMILVFG--FQALYVVDAMKHEEAILTTMDIVHDGFGFMLAFGDLCWVPFTYSLQGYFLVRHPQELSTYAAVGIILLNAVGYIIFRGSNSQKNAFRRNPADPKVVGLETIPTATGKRLLVSGWWGLVRHPNYLGDLIMALAWSLPCGLSNILPYFYVIYFTVLLVHREARDEHQCMKKYGVAWQEYCRRVPYRIFPYIY 413

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BLAST of Lamin-B receptor vs. Ensembl Xenopus
Match: rp9 (retinitis pigmentosa 9 (autosomal dominant) [Source:Xenbase;Acc:XB-GENE-944905])

HSP 1 Score: 227.254 bits (578), Expect = 1.919e-66
Identity = 132/392 (33.67%), Postives = 219/392 (55.87%), Query Frame = 3

Query:  465 VFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGK-TAYSTTKKGIEVKYRFNGVISMIITITSLAG-LMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA--FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            ++LL   S + A +  +      L    D   + +++ W+   A L  +PIGK T   T +    +KYR N + +M++T    AG +M+   L+   VYD++  +   +  +A++    L  KS    +  +A      N +Y+F +G E+N R    DLK+F E RPG  GW ++N+ F +KD+E R   S++  L+F    Q +Y +DA+  E  I++   +++  FGF    G+   VPF ++L    +  +  +L       I ++N +GYII+R SN QKN+FR+NP    +  L+TI    G ++LV GWWGL+RHPNY GD+I+ L+WSL  GL+  + +FY IYF + ++ R  +D+ +C  ++G AW +Y + VPYR+ P+++
Sbjct:  136 LYLLVTCSTEDASVLRVPGPWPALDTLWDPFAVILLLSWVSLQAVLYMLPIGKVTEGITLRDNTRLKYRINALQAMMVTALIAAGAVMFGFPLS--YVYDHFLQMAVGAAFIALILSIFLYAKSLAAPQSALAPGGNSGNPLYDFFIGHELNPRIGSFDLKYFCELRPGLIGWCLINLCFLMKDIELRGSPSLSMILVFG--FQALYVVDAMKHEEAILTTMDIVHDGFGFMLAFGDLCWVPFTYSLQGYFLVRHPQELSTYAAVGIILLNAVGYIIFRGSNSQKNAFRRNPADPKVVGLETIPTATGKRLLVSGWWGLVRHPNYLGDLIMALAWSLPCGLSNILPYFYVIYFTVLLVHREARDEHQCMKKYGVAWQEYCRRVPYRIFPYIY 523

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BLAST of Lamin-B receptor vs. Ensembl Xenopus
Match: rp9 (retinitis pigmentosa 9 (autosomal dominant) [Source:Xenbase;Acc:XB-GENE-944905])

HSP 1 Score: 223.402 bits (568), Expect = 3.756e-66
Identity = 130/392 (33.16%), Postives = 217/392 (55.36%), Query Frame = 3

Query:  465 VFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAY-STTKKGIEVKYRFNGVISMIITITSLAG-LMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA--FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            ++LL   S + A +  +      L    D   + +++ W+   A L  +PIGK  +         +KYR N + +M++T    AG +M+   L+   VYD++  +   +  +A++    L  KS    +  +A      N +Y+F +G E+N R    DLK+F E RPG  GW ++N+ F +KD+E R   S++  L+F    Q +Y +DA+  E  I++   +++  FGF    G+   VPF ++L    +  +  +L       I ++N +GYII+R SN QKN+FR+NP    +  L+TI    G ++LV GWWGL+RHPNY GD+I+ L+WSL  GL+  + +FY IYF + ++ R  +D+ +C  ++G AW +Y + VPYR+ P+++
Sbjct:   38 LYLLVTCSTEDASVLRVPGPWPALDTLWDPFAVILLLSWVSLQAVLYMLPIGKVFHVEYVLYNTRLKYRINALQAMMVTALIAAGAVMFGFPLS--YVYDHFLQMAVGAAFIALILSIFLYAKSLAAPQSALAPGGNSGNPLYDFFIGHELNPRIGSFDLKYFCELRPGLIGWCLINLCFLMKDIELRGSPSLSMILVFG--FQALYVVDAMKHEEAILTTMDIVHDGFGFMLAFGDLCWVPFTYSLQGYFLVRHPQELSTYAAVGIILLNAVGYIIFRGSNSQKNAFRRNPADPKVVGLETIPTATGKRLLVSGWWGLVRHPNYLGDLIMALAWSLPCGLSNILPYFYVIYFTVLLVHREARDEHQCMKKYGVAWQEYCRRVPYRIFPYIY 425

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BLAST of Lamin-B receptor vs. Ensembl Xenopus
Match: lbr (lamin B receptor [Source:NCBI gene;Acc:100145693])

HSP 1 Score: 221.09 bits (562), Expect = 5.191e-64
Identity = 140/446 (31.39%), Postives = 231/446 (51.79%), Query Frame = 3

Query:  318 ESKKPQ---LLDNGNTENFDKPKVKVLSKFQIYFKSMKSIMFCCMVFSL-IPAVF--LLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLT--EKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            ES  P+   L D+G TE+  +   K     ++ F         C++F +  PA+   LL       A +    +  ++L    D +  G  + W++  A+LA +P+GK         G  +KYR NG+    +T  + A +MY   +    VY++Y     S+ L +++F   L ++SY    E++       +FIY F +GREIN R   LDLK F+ F+     W+++N +    ++E +     + S++     Q++Y LD        +  P +    FGF    G+  I+PF ++L    +  N   LP +   +I  +NL+G+IIYR +N QK++FRQNP    L HLKT+    G ++L+ GWWG +R PNY GDII+ ++W L  G N  V +FY I+ +L ++ R  +D+++C  ++G  W+ Y K V YRL+P+V+
Sbjct:  107 ESSIPKGIVLTDSGPTESLPETAEKNAENPKLAFGGTVG----CLLFMICFPALLYCLLVACGPQSASV----YPSLEL---LDAQVFGFFVLWILLQASLAILPLGKVVDGVQLGNGSRLKYRMNGIHVFFLTAATAAAMMYYYKINILYVYEHYLQFAASATLFSLLFSVYLYVRSYRVPNEELSWTANSGSFIYKFFMGREINPRIGNLDLKTFFMFQLALISWVLINAVMLFAEMEVQGRDEPSLSMILVNSLQLLYVLDGFWNLEYFLMSPDITRDGFGFLLAFGSAAILPFTYSLQAYYLVNNPVDLPWQAACAIVALNLLGFIIYRGANSQKSAFRQNPDDPRLSHLKTLPTSAGSKLLISGWWGFVRRPNYLGDIIMGVAWCLPCGFNNMVPYFYAIFLILILLDRVARDEQRCREKYGPDWDKYCKHVRYRLLPYVY 541

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BLAST of Lamin-B receptor vs. Ensembl Mouse
Match: Lbr (lamin B receptor [Source:MGI Symbol;Acc:MGI:2138281])

HSP 1 Score: 224.172 bits (570), Expect = 1.583e-64
Identity = 117/357 (32.77%), Postives = 200/357 (56.02%), Query Frame = 3

Query:  564 GIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA-FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            G+ + W    A    +P+GK A  T    G  ++YR NG+ + I+T  +L   ++       + Y ++  L  ++   +V+    L ++S    + +++     N +Y+F +GRE+N R    DLKFF E RPG  GW+++N++  L +++ +E  + + +++     Q++Y +DA+  E  +++   +++  FGF    G+ V VPF ++L    +  +   L     + I  + L GY+I+R +N QKN+FR+NP    L HLKTI    G  +LV GWWG +RHPNY GD+I+ L+WSL  G N  + +FY IYF   +I R  +D+ +C  ++G AW  Y + VPYR+ P+++
Sbjct:  271 GVYLLWFFVQALFHLLPVGKVAEGTPLVDGRRLQYRLNGLYAFILTSAALGAAVFWGVELCYL-YTHFLQLALAATGFSVLLSAYLYVRSLRAPREELSPASSGNAVYDFFIGRELNPRLGAFDLKFFCELRPGLIGWVVINLVMLLMEMKIQERAAPSLAMILVNSFQLLYVVDALWNEEALLTSMDIMHDGFGFMLAFGDLVWVPFTYSLQAFYLVSHPHDLSWPLASVIIALKLCGYVIFRCANSQKNAFRKNPTDPKLAHLKTIHTSTGKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHLLPYFYIIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY 626

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BLAST of Lamin-B receptor vs. Ensembl Mouse
Match: Tm7sf2 (transmembrane 7 superfamily member 2 [Source:MGI Symbol;Acc:MGI:1920416])

HSP 1 Score: 201.445 bits (511), Expect = 5.330e-58
Identity = 93/253 (36.76%), Postives = 155/253 (61.26%), Query Frame = 3

Query:  870 NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            N +Y+F +GRE+N R    D K+F E RPG  GW+ +N+   +++ E R   S+  ++      Q++Y  DA+ +E  +++   +++  FGF    G+   VPF ++L  + +  +   L +     I ++ +IGY I+R +N QKN+FR+NP    +  L+TI    G Q+LV GWWG++RHPNY GD+I+ L+WSL  GL+  + +FY +YF   ++ R  +D+++C  ++G AW +Y K VPYR+IP+V+
Sbjct:  168 NSMYDFFLGRELNPRLGSFDFKYFCELRPGLIGWVFINLALLMQEAELRGSPSL--AMWLVNGFQLLYVGDALWYEESVLTTMDIIHDGFGFMLVFGDLAWVPFTYSLQAQFLLYHPQPLGLPMALLICLLKVIGYYIFRGANSQKNTFRKNPSDPSVAGLETIPTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGLSHLLPYFYVLYFTALLVHREARDEQQCLQKYGRAWQEYCKRVPYRIIPYVY 418

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BLAST of Lamin-B receptor vs. Ensembl Mouse
Match: Tm7sf2 (transmembrane 7 superfamily member 2 [Source:MGI Symbol;Acc:MGI:1920416])

HSP 1 Score: 160.229 bits (404), Expect = 3.427e-43
Identity = 82/256 (32.03%), Postives = 139/256 (54.30%), Query Frame = 3

Query:  870 NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLK---TITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            N +Y+F +GRE+N R    D K+F E RPG  GW+ +N+   +++ E R   S+  ++      Q++Y  DA+ +E  +++   +++  FGF    G+   VPF ++L  +                        +++Y    +        P ++ +C LK   TI    G Q+LV GWWG++RHPNY GD+I+ L+WSL  GL+  + +FY +YF   ++ R  +D+++C  ++G AW +Y K VPYR+IP+V+
Sbjct:  168 NSMYDFFLGRELNPRLGSFDFKYFCELRPGLIGWVFINLALLMQEAELRGSPSL--AMWLVNGFQLLYVGDALWYEESVLTTMDIIHDGFGFMLVFGDLAWVPFTYSLQAQ------------------------FLLYHPQPLGL------PMALLICLLKGLETIPTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGLSHLLPYFYVLYFTALLVHREARDEQQCLQKYGRAWQEYCKRVPYRIIPYVY 391

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BLAST of Lamin-B receptor vs. Ensembl Mouse
Match: Tm7sf2 (transmembrane 7 superfamily member 2 [Source:MGI Symbol;Acc:MGI:1920416])

HSP 1 Score: 158.688 bits (400), Expect = 1.573e-42
Identity = 77/207 (37.20%), Postives = 123/207 (59.42%), Query Frame = 3

Query:  870 NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAI--QINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFG 1484
            N +Y+F +GRE+N R    D K+F E RPG  GW+ +N+   +++ E R   S+  ++      Q++Y  DA+ +E  +++   +++  FGF    G+   VPF ++L  + +        LP+  L  I ++ +IGY I+R +N QKN+FR+NP    +  L+TI    G Q+LV GWWG++RHPNY GD+I+ L+WSL  GL+ G
Sbjct:  168 NSMYDFFLGRELNPRLGSFDFKYFCELRPGLIGWVFINLALLMQEAELRGSPSL--AMWLVNGFQLLYVGDALWYEESVLTTMDIIHDGFGFMLVFGDLAWVPFTYSLQAQFLLYHPQPLGLPMALL--ICLLKVIGYYIFRGANSQKNTFRKNPSDPSVAGLETIPTATGRQLLVSGWWGMVRHPNYLGDLIMALAWSLPCGLSHG 370

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BLAST of Lamin-B receptor vs. Ensembl Mouse
Match: Dhcr7 (7-dehydrocholesterol reductase [Source:MGI Symbol;Acc:MGI:1298378])

HSP 1 Score: 140.969 bits (354), Expect = 1.349e-35
Identity = 100/346 (28.90%), Postives = 170/346 (49.13%), Query Frame = 3

Query:  633 STTKKGIEVKYRFNGVISMIIT-ITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYL--TEKIKIAFRPINFIYNFIVGREINTRFF-GLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQN----------PYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            + T  G+  KY  NG+ + +IT I            +  +++DN+  L+  + ++        ++K YL  T      F   NF YN+++G E N R     D K F+  RPG   W ++N+ F  K  E   +  +  S++   + Q IY LD    E   +    + +  FG++   G+ V +P+L+TL    +  +  QL       I ++ L+GY I+R +N QK+ FR+           P ++   +      +H  ++LV G+WG+ RH NY GD++  L++ L  G    + +FY IY  + +  RC++D+ +CA ++G  W  Y  AVPYRL+P +F
Sbjct:  132 AITPAGVVNKYEVNGLQAWLITHILWFVNAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIKGYLFPTSAEDCKFTG-NFFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSFAAKQQE--LYGHVTNSMILVNVLQAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPNALGILLLGLVGYYIFRMTNHQKDLFRRTDGRCLIWGKKPKAIECSYTSADGLKHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLTHRCLRDEHRCANKYGRDWERYTAAVPYRLLPGIF 474

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BLAST of Lamin-B receptor vs. UniProt/SwissProt
Match: sp|Q3U9G9|LBR_MOUSE (Delta(14)-sterol reductase LBR OS=Mus musculus OX=10090 GN=Lbr PE=1 SV=2)

HSP 1 Score: 224.172 bits (570), Expect = 1.108e-63
Identity = 117/357 (32.77%), Postives = 200/357 (56.02%), Query Frame = 3

Query:  564 GIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA-FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            G+ + W    A    +P+GK A  T    G  ++YR NG+ + I+T  +L   ++       + Y ++  L  ++   +V+    L ++S    + +++     N +Y+F +GRE+N R    DLKFF E RPG  GW+++N++  L +++ +E  + + +++     Q++Y +DA+  E  +++   +++  FGF    G+ V VPF ++L    +  +   L     + I  + L GY+I+R +N QKN+FR+NP    L HLKTI    G  +LV GWWG +RHPNY GD+I+ L+WSL  G N  + +FY IYF   +I R  +D+ +C  ++G AW  Y + VPYR+ P+++
Sbjct:  271 GVYLLWFFVQALFHLLPVGKVAEGTPLVDGRRLQYRLNGLYAFILTSAALGAAVFWGVELCYL-YTHFLQLALAATGFSVLLSAYLYVRSLRAPREELSPASSGNAVYDFFIGRELNPRLGAFDLKFFCELRPGLIGWVVINLVMLLMEMKIQERAAPSLAMILVNSFQLLYVVDALWNEEALLTSMDIMHDGFGFMLAFGDLVWVPFTYSLQAFYLVSHPHDLSWPLASVIIALKLCGYVIFRCANSQKNAFRKNPTDPKLAHLKTIHTSTGKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHLLPYFYIIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY 626

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BLAST of Lamin-B receptor vs. UniProt/SwissProt
Match: sp|O08984|LBR_RAT (Delta(14)-sterol reductase LBR OS=Rattus norvegicus OX=10116 GN=Lbr PE=1 SV=1)

HSP 1 Score: 220.705 bits (561), Expect = 2.135e-62
Identity = 118/367 (32.15%), Postives = 204/367 (55.59%), Query Frame = 3

Query:  534 LQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA-FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            L+   + +  G+ + W    A  + +P+GK    T    G  +KYR NG+ + I+T  ++   ++   +    +Y ++     ++I+ +VV    L  +S    + +++     N +Y+F +GRE+N R    DLKFF E RPG  GW+++N++  L +++ +E  + + ++      Q++Y +DA+ FE  +++   +++  FGF    G+ V VPF ++L    +  +   L     + I  + L GY+I+R +N QKN+FR+NP    L HLKTI       +LV GWWG +RHPNY GD+I+ L+WSL  G N  + +FY IYF   +I R  +D+ +C  ++G AW  Y + VPYR+ P+++
Sbjct:  255 LRELWEARVCGVYLLWFFLQALFSLLPVGKVVEGTPLVDGRRLKYRLNGLYAFILTSAAVGTAVFWD-IELYYLYTHFLQFALAAIVFSVVLSVYLYARSLKVPRDELSPASSGNAVYDFFIGRELNPRIGAFDLKFFCELRPGLIGWVVINLVMLLAEMKVQERSAPSLAMTLVNSFQLLYVVDALWFEEALLTTMDIIHDGFGFMLAFGDLVWVPFTYSLQAFYLVNHPQDLSWPLTSVIIALKLCGYVIFRCANSQKNAFRKNPTDPKLAHLKTIPTSTWKSLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYVIYFTALLIHREARDEHQCRRKYGLAWEKYCQRVPYRIFPYIY 620

[Close]

BLAST of Lamin-B receptor vs. UniProt/SwissProt
Match: sp|Q14739|LBR_HUMAN (Delta(14)-sterol reductase LBR OS=Homo sapiens OX=9606 GN=LBR PE=1 SV=2)

HSP 1 Score: 216.853 bits (551), Expect = 4.261e-61
Identity = 117/359 (32.59%), Postives = 199/359 (55.43%), Query Frame = 3

Query:  564 GIVICWLMYLAALAHIPIGKTAYSTTK-KGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA-FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAI--QINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            G+ + W +       +PIGK    T    G  +KYR NG  + I+T +++ G    + +    VY ++     ++ +  VV    L ++S    +  ++     N +Y+F +GRE+N R    DLK+F E RPG  GW+++N++  L +++ ++    + +++     Q++Y +DA+  E  +++   +++  FGF    G+ V VPF+++     +    N    P+  L  I V+ L GY+I+R +N QKN+FR+NP    L HLKTI    G  +LV GWWG +RHPNY GD+I+ L+WSL  G N  + +FY IYF + ++ R  +D+  C  ++G AW  Y + VPYR+ P+++
Sbjct:  260 GVYLLWFLIQVLFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILT-SAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASL--IIVLKLCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFVRHPNYLGDLIMALAWSLPCGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 615

[Close]

BLAST of Lamin-B receptor vs. UniProt/SwissProt
Match: sp|Q5R7H4|LBR_PONAB (Delta(14)-sterol reductase LBR OS=Pongo abelii OX=9601 GN=LBR PE=2 SV=1)

HSP 1 Score: 215.698 bits (548), Expect = 1.310e-60
Identity = 116/359 (32.31%), Postives = 197/359 (54.87%), Query Frame = 3

Query:  564 GIVICWLMYLAALAHIPIGKTAYSTTK-KGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA-FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAI--QINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            G+ + W +       +PIGK    T    G  +KYR NG  + I+T +++ G    + +    VY ++     ++ +  VV    L ++S    +  ++     N +Y+F +GRE+N R    DLK+F E RPG  GW+++N++  L +++ ++    + +++     Q++Y +DA+  E  +++   +++  FGF    G+ V VPF+++     +    N    P+  L  I V+   GY+I+R +N QKN+FR+NP    L HLKTI    G  +LV GWWG  RHPNY GD+I+ L+WSL  G N  + +FY IYF + ++ R  +D+  C  ++G AW  Y + VPYR+ P+++
Sbjct:  260 GVYLLWFLIQVVFYLLPIGKVVEGTPLIDGRRLKYRLNGFYAFILT-SAVIGTSLFQGVEFHYVYSHFLQFALAATVFCVVLSVYLYMRSLKAPRNDLSPASSGNAVYDFFIGRELNPRIGTFDLKYFCELRPGLIGWVVINLVMLLAEMKIQDRAVPSLAMILVNSFQLLYVVDALWNEEALLTTMDIIHDGFGFMLAFGDLVWVPFIYSFQAFYLVSHPNEVSWPMASL--IIVLKFCGYVIFRGANSQKNAFRKNPSDPKLAHLKTIHTSTGKNLLVSGWWGFARHPNYLGDLIMALAWSLACGFNHILPYFYIIYFTMLLVHREARDEYHCKKKYGVAWEKYCQRVPYRIFPYIY 615

[Close]

BLAST of Lamin-B receptor vs. UniProt/SwissProt
Match: sp|P23913|LBR_CHICK (Delta(14)-sterol reductase LBR OS=Gallus gallus OX=9031 GN=LBR PE=1 SV=1)

HSP 1 Score: 207.223 bits (526), Expect = 2.150e-57
Identity = 114/364 (31.32%), Postives = 191/364 (52.47%), Query Frame = 3

Query:  534 LQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLT--EKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLI 1616
            L+   + K  G+ + W  + A    +PIGK           +++YR NG  + ++T  ++  L+Y +      +YD++     S+   ++     L ++S     E +         +Y+F  G E+N R    DLK+F E RPG  GW+++N+   L +++       + S++     Q++Y +DA+  E  +++   + +  FGF    G+ V VPF+++L    +  +   +     A+I ++N IGY I+RS+N QKN+FR+NP    L +LK I    G  +LV GWWG +RHPNY GDII+ L+WSL  G N  + +FY IYF+  ++ R  +D+  C  ++G AW  Y + VPY  I
Sbjct:  242 LESLWETKVFGVFLLWFFFQALFYLLPIGKVVEGLPLSNPRKLQYRINGFYAFLLTAAAIGTLLYFQ-FELHYLYDHFVQFAVSAAAFSMALSIYLYIRSLKAPEEDLAPGGNSGYLVYDFFTGHELNPRIGSFDLKYFCELRPGLIGWVVINLAMLLAEMKIHNQSMPSLSMILVNSFQLLYVVDALWNEEAVLTTMDITHDGFGFMLAFGDLVWVPFVYSLQAFYLVGHPIAISWPVAAAITILNCIGYYIFRSANSQKNNFRRNPADPKLSYLKVIPTATGKGLLVTGWWGFVRHPNYLGDIIMALAWSLPCGFNHILPYFYVIYFICLLVHREARDEHHCKKKYGLAWERYCQRVPYTHI 604

[Close]

BLAST of Lamin-B receptor vs. TrEMBL
Match: V3ZS14 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_118629 PE=4 SV=1)

HSP 1 Score: 253.832 bits (647), Expect = 1.928e-74
Identity = 148/401 (36.91%), Postives = 231/401 (57.61%), Query Frame = 3

Query:  441 MVFSLIPAVFLLN-KMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIA--FRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQIN-NFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            ++F L   V+LLN   ++    I  I     +L +F D +   I + W  + A LA IP GK A     + G ++KYR NG IS+II++ +    +Y K L   +++  ++ ++ ++ + +V     L +KS L  + K+A      N +Y+F +G E+N R    DLKFF E RPG  GW+ILN+ F  K   D        +L  CA  QI Y  DA+  E  I++   +++  FGF    G+ V VPF++ L TR +  N    +   CLA IAVINL+GY I+R +N QK+++R+NP++  L HL+T+    G ++LV GWWG+ R PNY GD+++  +WSL  GL+  + +FYPIYFL+ ++ RC +DD  C  ++G  W  Y + VPY++IP+++
Sbjct:   26 LIFLLPATVYLLNFACNKKRCTIMEIPKLPSRLSFFIDLQATYIFLGWFFFQAILAIIPFGKLAEGQPLRSGQKLKYRCNGFISLIISMVAFGIAVYYK-LPVTIIHTKFFQIMTAATIFSVSLSLFLYIKSLLIPQDKLAPGGNTGNHVYDFFMGHELNPRIGMFDLKFFCELRPGLIGWVILNMAFVYKAYLDNN-NVFPPALTMCAAFQIFYVADALFAEEAILTTMDIVHDGFGFMLIFGDLVWVPFIYCLQTRFLLENPQNDMYWYCLAFIAVINLVGYYIFRGANSQKDAYRRNPHNPALAHLETLPTSTGRKLLVSGWWGICRKPNYLGDLLMATAWSLCCGLHHVLPYFYPIYFLILLVHRCQRDDVICRKKYGAVWTRYCQRVPYKIIPYIY 424

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BLAST of Lamin-B receptor vs. TrEMBL
Match: A0A1S3HT82 (delta(14)-sterol reductase isoform X3 OS=Lingula unguis OX=7574 GN=LOC106157959 PE=4 SV=1)

HSP 1 Score: 254.988 bits (650), Expect = 8.438e-74
Identity = 159/467 (34.05%), Postives = 260/467 (55.67%), Query Frame = 3

Query:  246 TRRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKV-KVLSKFQIYFKSMKSIMFCCMVFSLIPA-VFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTTKKGIE-VKYRFNGVISMIITITSLA-GLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAFRPI-NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTI-TNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            TR+S ++  K     + +E +   E K         T   DKP   K ++  +  F       FC +   L+PA V+++N M  + +    I     KL  + D K + I + W ++   LA +P+GK       KG++ ++YR NG I++++++ +L  G  Y K +    V+  +  LI ++I+ +VV   +L +++   +   +AF    N IY+F +GRE+N R    D KFF E RPG  GW+ +N+ F L +    +    NY L+     Q++Y  DA+  E  I++   +++  FGF  C G+   VPFL++L  R +  +   LP   L+++A++N+IG++I+R SN QKN FR+NPY   L HL+++ TN  G ++LV GWWGL RHPNY GD+II L+WSL  G +  + +FYPIYF + ++ R ++DD  C  ++G  W+ Y + V Y +IP+V+
Sbjct:   65 TRQSARLAEKQTNGPEEVEKKPEMERKPSPARPAVATPVADKPVADKPVADSE--FGGPVGAFFCIV---LLPATVYVINIMCTEKSCTLAIPSIPKKLSNYFDSKAVMIGLGWFVFQVVLAVLPVGKVVSGQPVKGLQRLQYRCNGFIALMVSLVALGVGQAYFK-VDLSTVHTLWLQLITTAIVFSVVLSLVLYIRARSAKPNALAFAASGNAIYDFWMGRELNPRIGSFDWKFFCELRPGLIGWVAINMCF-LAEAYGSKSGWPNYPLIMVCGFQLLYVADALWSEEAILTTMDIIHEGFGFMLCFGDLAWVPFLYSLQPRFLLEHPQSLPWWALSAVALLNMIGFLIFRGSNSQKNMFRKNPYDPALAHLESMPTNVPGKRLLVSGWWGLCRHPNYLGDLIIGLAWSLPCGFSSLLPYFYPIYFFILLVHRAMRDDAMCRKKYGAHWDHYCERVKYVIIPYVY 524

[Close]

BLAST of Lamin-B receptor vs. TrEMBL
Match: A0A1S3HT59 (delta(14)-sterol reductase isoform X2 OS=Lingula unguis OX=7574 GN=LOC106157959 PE=4 SV=1)

HSP 1 Score: 254.988 bits (650), Expect = 1.186e-73
Identity = 159/467 (34.05%), Postives = 260/467 (55.67%), Query Frame = 3

Query:  246 TRRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKV-KVLSKFQIYFKSMKSIMFCCMVFSLIPA-VFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTTKKGIE-VKYRFNGVISMIITITSLA-GLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAFRPI-NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTI-TNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            TR+S ++  K     + +E +   E K         T   DKP   K ++  +  F       FC +   L+PA V+++N M  + +    I     KL  + D K + I + W ++   LA +P+GK       KG++ ++YR NG I++++++ +L  G  Y K +    V+  +  LI ++I+ +VV   +L +++   +   +AF    N IY+F +GRE+N R    D KFF E RPG  GW+ +N+ F L +    +    NY L+     Q++Y  DA+  E  I++   +++  FGF  C G+   VPFL++L  R +  +   LP   L+++A++N+IG++I+R SN QKN FR+NPY   L HL+++ TN  G ++LV GWWGL RHPNY GD+II L+WSL  G +  + +FYPIYF + ++ R ++DD  C  ++G  W+ Y + V Y +IP+V+
Sbjct:   77 TRQSARLAEKQTNGPEEVEKKPEMERKPSPARPAVATPVADKPVADKPVADSE--FGGPVGAFFCIV---LLPATVYVINIMCTEKSCTLAIPSIPKKLSNYFDSKAVMIGLGWFVFQVVLAVLPVGKVVSGQPVKGLQRLQYRCNGFIALMVSLVALGVGQAYFK-VDLSTVHTLWLQLITTAIVFSVVLSLVLYIRARSAKPNALAFAASGNAIYDFWMGRELNPRIGSFDWKFFCELRPGLIGWVAINMCF-LAEAYGSKSGWPNYPLIMVCGFQLLYVADALWSEEAILTTMDIIHEGFGFMLCFGDLAWVPFLYSLQPRFLLEHPQSLPWWALSAVALLNMIGFLIFRGSNSQKNMFRKNPYDPALAHLESMPTNVPGKRLLVSGWWGLCRHPNYLGDLIIGLAWSLPCGFSSLLPYFYPIYFFILLVHRAMRDDAMCRKKYGAHWDHYCERVKYVIIPYVY 536

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BLAST of Lamin-B receptor vs. TrEMBL
Match: A0A3S0ZQQ3 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_011701 PE=4 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 4.198e-73
Identity = 155/472 (32.84%), Postives = 251/472 (53.18%), Query Frame = 3

Query:  231 VARRVTRRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKVKVLSKFQIYFKSMKSIMFCCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQY---FTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAF--RPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
             A    R S +I S  L   +      + E  K +++ N  T     PK K       +++ M  I    ++F L+PA      M+    K   +    +   +   F D +   I   W+ + A LA +P+G+       K G ++KYR NG +++++++  L   +Y K    K+V D ++ L+  + + +  F   L + S+     K+A      NFIY+F +GRE+N R   LDLKFF E RPG  GW++++ I  LK  +  E  +   +L+   + Q +Y  DA+ FE  I++   +++  FGF  C G+ V VPFL++L  R +  + F LP  CLA I VINLIGY+I+R SN QKN FR++P       ++T+  + G ++L  GWWG+   PNY GD+I+ L+WSL +G      +FYP+YFL+ +I R  +D+ +CA ++G +W  Y + V YR+ P+++
Sbjct:  110 AAHTPVRSSSRIAS--LIEKEKEASYLIKEQMKSEMITNMKTPPPSAPKKKEKGP---HYEFMGPIGAFLLIF-LLPATVYYVNMACRKTKCSILIVPSLPRNFVAAFFDTEACLIFFGWMAFQALLAVLPVGRLVDGQPLKSGGKLKYRCNGFLALVVSLAGLGVAVYLKLPVTKVV-DKFFKLMTVATIFSFAFSICLYVSSHFVSSKKLAPGGNSGNFIYDFFIGRELNPRVGPLDLKFFCELRPGLIGWVMMDWIMVLKAYQ--ETGTFPPNLVLVTVFQTLYVADALWFEDAILTTMDIIHDGFGFMLCFGDLVWVPFLYSLQPRFLLESGFTLPWYCLAPIVVINLIGYMIFRLSNSQKNLFRKDPKHPVFSGMETVPTQTGRKLLASGWWGICHKPNYLGDLIMALAWSLTTGFGHIFTYFYPLYFLVLLIHRERRDNEQCAAKYGASWERYCQRVKYRIFPYIY 572

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BLAST of Lamin-B receptor vs. TrEMBL
Match: A0A1S3HT56 (delta(14)-sterol reductase isoform X1 OS=Lingula unguis OX=7574 GN=LOC106157959 PE=4 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 5.190e-73
Identity = 159/467 (34.05%), Postives = 260/467 (55.67%), Query Frame = 3

Query:  246 TRRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKV-KVLSKFQIYFKSMKSIMFCCMVFSLIPA-VFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTTKKGIE-VKYRFNGVISMIITITSLA-GLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAFRPI-NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTI-TNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            TR+S ++  K     + +E +   E K         T   DKP   K ++  +  F       FC +   L+PA V+++N M  + +    I     KL  + D K + I + W ++   LA +P+GK       KG++ ++YR NG I++++++ +L  G  Y K +    V+  +  LI ++I+ +VV   +L +++   +   +AF    N IY+F +GRE+N R    D KFF E RPG  GW+ +N+ F L +    +    NY L+     Q++Y  DA+  E  I++   +++  FGF  C G+   VPFL++L  R +  +   LP   L+++A++N+IG++I+R SN QKN FR+NPY   L HL+++ TN  G ++LV GWWGL RHPNY GD+II L+WSL  G +  + +FYPIYF + ++ R ++DD  C  ++G  W+ Y + V Y +IP+V+
Sbjct:  123 TRQSARLAEKQTNGPEEVEKKPEMERKPSPARPAVATPVADKPVADKPVADSE--FGGPVGAFFCIV---LLPATVYVINIMCTEKSCTLAIPSIPKKLSNYFDSKAVMIGLGWFVFQVVLAVLPVGKVVSGQPVKGLQRLQYRCNGFIALMVSLVALGVGQAYFK-VDLSTVHTLWLQLITTAIVFSVVLSLVLYIRARSAKPNALAFAASGNAIYDFWMGRELNPRIGSFDWKFFCELRPGLIGWVAINMCF-LAEAYGSKSGWPNYPLIMVCGFQLLYVADALWSEEAILTTMDIIHEGFGFMLCFGDLAWVPFLYSLQPRFLLEHPQSLPWWALSAVALLNMIGFLIFRGSNSQKNMFRKNPYDPALAHLESMPTNVPGKRLLVSGWWGLCRHPNYLGDLIIGLAWSLPCGFSSLLPYFYPIYFFILLVHRAMRDDAMCRKKYGAHWDHYCERVKYVIIPYVY 582

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BLAST of Lamin-B receptor vs. Ensembl Cavefish
Match: lbr (lamin-B receptor [Source:NCBI gene;Acc:103032852])

HSP 1 Score: 219.55 bits (558), Expect = 3.735e-63
Identity = 117/384 (30.47%), Postives = 216/384 (56.25%), Query Frame = 3

Query:  486 SEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLT--EKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            ++  A + + S     L+   D +  GIV+ WL++ A L+ +PIGK       K G  +KYR NG  ++II+  ++ G +Y + +    V+ ++     S++L++++    L ++S     ++   A    + +Y+F +GRE+N R    D+KFF E RPG  GW+++N    L +++ +   + + ++L     Q+++  D +  E  +++   +++  FGF    G+   VPF FT     +  +   L +  + +I ++N++GY I+R +N QK +FR+NP    L +LKTI    G  ++V G WG +RHPNY GD+I+ L+WSL  G +  + +FY IY ++ ++ R  +D+ +C  ++G+AW +Y K V YR++P ++
Sbjct:  222 AQTDASLLNFSLSPPLLEPLWDWQVFGIVVLWLLFQAVLSLLPIGKVVEGMPLKNGKTLKYRINGFSALIISALAVGGAVYYE-VDLSYVHAHFLQFYTSALLLSILLSIYLFIRSRCASEDERAPAGNTGHVVYDFFMGRELNPRIKSFDIKFFCEMRPGLIGWLVINFAMLLAEMKHKNLDTPSPAMLLVNGFQLLWVADGLWHEEKLLTMMDIVHDGFGFMLAFGDLAWVPFTFTCQAYYLVSHTSDLSVFWIVAIIIMNVVGYYIFRQANSQKFAFRRNPSDPALSYLKTIPTATGKNLIVSGLWGFVRHPNYLGDLIMALAWSLSCGFSHVIPYFYLIYLVVLLVHRDARDEHQCRKKYGSAWEEYCKVVRYRILPGIY 604

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BLAST of Lamin-B receptor vs. Ensembl Cavefish
Match: tm7sf2 (transmembrane 7 superfamily member 2 [Source:ZFIN;Acc:ZDB-GENE-041212-19])

HSP 1 Score: 209.92 bits (533), Expect = 3.028e-62
Identity = 113/331 (34.14%), Postives = 191/331 (57.70%), Query Frame = 3

Query:  642 KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAF--RPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            + G  +KY+ NG  ++ +T   L GL  +  +    ++D    L   +I V+ +    L + S+      +A      N +Y+F +GRE+N R    DLKFF E RPG  GW++LN+   +K++E R+  S+  ++L     Q++Y +DA+  E  +++   +++  FGF    G+   VPF + L    + ++   L    +  I ++N +GY I+R SN QKN FR++P    + HL+TI    G ++LV GWWG +RHPNY GDI++ L+WSL  G +  + +FY IYF + ++ R  +D+R+C  ++G AW++Y + VPYR+IP+++
Sbjct:    6 RDGTRLKYQINGFHALCMT-AMLLGLCVSLGMPLGYLFDLILPLAVCAICVSYLLALYLYIGSFWAPAHALALGGNTGNPLYDFFIGRELNPRIGSFDLKFFCELRPGLIGWVVLNMAMMMKEVELRDSPSL--AMLLVNGFQLLYVMDALWNEEAVLTTMDIVHDGFGFMLAFGDLAWVPFTYGLQAMFLVVHPRSLSPPTVIGIILLNGLGYYIFRKSNSQKNQFRRDPNHRSVAHLETIATATGKRLLVSGWWGFVRHPNYLGDILMALAWSLPCGFSHILPYFYVIYFSILLVHREARDERQCRAKYGIAWDNYCRRVPYRIIPYIY 333

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BLAST of Lamin-B receptor vs. Ensembl Cavefish
Match: si:ch1073-429i10.1 (delta(14)-sterol reductase-like [Source:NCBI gene;Acc:103022427])

HSP 1 Score: 155.606 bits (392), Expect = 2.774e-41
Identity = 100/361 (27.70%), Postives = 181/361 (50.14%), Query Frame = 3

Query:  567 IVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLI--GSSXXXXXXXXXXXXXKSYLTEKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLP--IKCLASIAVINLIGY--IIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            IV+ + +   AL ++P+G+        +   +KY  NG+ +  + +  L G      L A  V      L+  G ++ + +     L   S  + +         F+ +F++GRE + R   +D+K F   R GF GW ++++ + L+ +E     S++ +LL     Q++Y LD ++ E  ++     +    GF   LG  + +PF  +L    +     Q P  I  L+++ VI L G+  ++Y  SN QK+ FR+NP++     L+TI +  G  +LV GW+G +RHPNY GD+++ L+W L  G    + +   +     +  R  + +  C  +HG+AW +Y + VPY+LIP+++
Sbjct:   82 IVVIFTVLQGALYYLPVGQVVEGKMGNQEKRLKYSLNGLHAFGVCVVLLVGAWQGGWLVAGSVTGRVLPLVSAGCAVALLISVCLYLRPDSAHSHENTTG----GFLQDFLLGREADPRLGKIDVKQFAMVRIGFIGWGLMDVCYVLRGVES---DSVSSALLLTTTFQLVYILDFLIDEDTVLDTKEFMEDSIGFLMVLGEYIWIPFFSSLPVYFL----LQRPNHIHFLSAVPVILLFGFGFLVYYLSNEQKSGFRRNPHNPAYSRLETIRSPSGRNLLVSGWFGWVRHPNYLGDVVMMLAWCLPCGFCSVLPYLPALQCFNLLRKRSTEVEESCREKHGSAWAEYCRRVPYKLIPYIY 431

[Close]

BLAST of Lamin-B receptor vs. Ensembl Cavefish
Match: si:ch1073-429i10.1 (delta(14)-sterol reductase-like [Source:NCBI gene;Acc:103022427])

HSP 1 Score: 155.606 bits (392), Expect = 4.388e-41
Identity = 100/361 (27.70%), Postives = 181/361 (50.14%), Query Frame = 3

Query:  567 IVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLI--GSSXXXXXXXXXXXXXKSYLTEKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLP--IKCLASIAVINLIGY--IIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            IV+ + +   AL ++P+G+        +   +KY  NG+ +  + +  L G      L A  V      L+  G ++ + +     L   S  + +         F+ +F++GRE + R   +D+K F   R GF GW ++++ + L+ +E     S++ +LL     Q++Y LD ++ E  ++     +    GF   LG  + +PF  +L    +     Q P  I  L+++ VI L G+  ++Y  SN QK+ FR+NP++     L+TI +  G  +LV GW+G +RHPNY GD+++ L+W L  G    + +   +     +  R  + +  C  +HG+AW +Y + VPY+LIP+++
Sbjct:   96 IVVIFTVLQGALYYLPVGQVVEGKMGNQEKRLKYSLNGLHAFGVCVVLLVGAWQGGWLVAGSVTGRVLPLVSAGCAVALLISVCLYLRPDSAHSHENTTG----GFLQDFLLGREADPRLGKIDVKQFAMVRIGFIGWGLMDVCYVLRGVES---DSVSSALLLTTTFQLVYILDFLIDEDTVLDTKEFMEDSIGFLMVLGEYIWIPFFSSLPVYFL----LQRPNHIHFLSAVPVILLFGFGFLVYYLSNEQKSGFRRNPHNPAYSRLETIRSPSGRNLLVSGWFGWVRHPNYLGDVVMMLAWCLPCGFCSVLPYLPALQCFNLLRKRSTEVEESCREKHGSAWAEYCRRVPYKLIPYIY 445

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BLAST of Lamin-B receptor vs. Ensembl Cavefish
Match: dhcr7 (7-dehydrocholesterol reductase [Source:NCBI gene;Acc:103033332])

HSP 1 Score: 150.599 bits (379), Expect = 4.101e-39
Identity = 98/348 (28.16%), Postives = 171/348 (49.14%), Query Frame = 3

Query:  633 STTKKGIEVKYRFNGVISMIIT-ITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYL----TEKIKIAFRPINFIYNFIVGREINTRFF-GLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQN----------PYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            + T  G+  KY  NG+   IIT    +A   Y    +  +++DN+  L+  + ++         +K+YL     E  K      N  YN+++G E N R     D K F+  RPG   W ++N+ +  K  E   +  +  S++   + Q IY +D    E   +    + +  FG++   G+ V +PFL+TL    +  N  QL    +A + ++ L+GY I+RS+N QK+ FR+           P  +   +       H  +++  G+WG+ RH NY GD++  L++ L  G    + +FY IY  + ++ RC++D+ +C+ ++G  W  Y +AVP RL+P +F
Sbjct:  136 ARTPAGLINKYEINGLQCWIITHALWVANAYYFHWFSPTIIFDNWIPLLWCTNILGYAVSTFAFIKAYLFPTNPEDCKYTG---NIFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYAAKQQE--LYGYVTNSMILVNVLQAIYVVDFFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPFLYTLQGLYLVYNPVQLSTPNVAGVLILGLLGYYIFRSANHQKDLFRRTEGKCTIWGRKPAYIECSYRSADGGTHKSKLMTSGFWGVTRHMNYTGDLMGSLAYCLACGGGHLLPYFYIIYMTILLVHRCIRDEHRCSNKYGKDWKRYTEAVPQRLLPGIF 478

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BLAST of Lamin-B receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002700.1 (pep scaffold:Pmarinus_7.0:GL480753:6556:12779:-1 gene:ENSPMAG00000002452.1 transcript:ENSPMAT00000002700.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 142.51 bits (358), Expect = 3.025e-37
Identity = 74/253 (29.25%), Postives = 131/253 (51.78%), Query Frame = 3

Query:  870 NFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            N  Y+F++GRE+N R   L++K F E R G  GW++L  +  L   + R+  +   +L   A  QI+Y   A+  EG +++         GF     +    P + +L    +     QLP+   AS+A++  +G  IY  ++ ++ +F+  P   H    ++I    G ++LV GWWG+LRHP+  G +++ ++W+L  G+   + W   +Y    ++ R V  ++ C   +G AW +Y   VPYRL+P ++
Sbjct:  179 NMAYDFVLGRELNPRMGALNVKHFCELRLGLLGWVVL--VLGLVAAQTRDAGTPCSALALVATFQIVYVAAALWNEGKLVAALDTSPLGAGFLLLFIDLAWTPLVCSLPAAYLVQQPLQLPLYHSASLALLYGLGLYIYCRASAERRAFQHKPSLAHSSRKESIPTATGKRLLVSGWWGVLRHPDTLGQLLMTMAWTLPCGVQAALPWVQAVYVCGALLVRGVHTEQACVRRYGAAWAEYCHRVPYRLLPGLY 429

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BLAST of Lamin-B receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000142.1 (pep scaffold:Pmarinus_7.0:GL476617:408941:423101:1 gene:ENSPMAG00000000122.1 transcript:ENSPMAT00000000142.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 134.035 bits (336), Expect = 2.013e-33
Identity = 97/327 (29.66%), Postives = 169/327 (51.68%), Query Frame = 3

Query:  567 IVIC--WLMYLAALAHIPIG-KTAYSTTKKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAF--RPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITR 1532
            +V+C  W ++ A L H+P+G  T          +KYR NG+ +++++I++ +   Y +   A  V+D +  L  S++L+A +    L +++     I +A   RP N  Y+F  GRE+N R   +DLK F+E RPGF GW I++++  L+DL+  E  + + +LL     Q IY  D +  E   +S   + +  FGF     N   +PF  +L    +  ++ +L     A+I ++ L+GY+I R ++ QKN+   +         K   +R      V G WG LRHP   G++++ L+WSL  G +  + +   +Y L+ ++ R
Sbjct:  281 LVLCLGWCLFQALLCHLPLGYVTERVPPNTEQRLKYRLNGIHALVLSISAFSLAKYKEAYVA-YVHDKFLQLAVSAVLLAYLLSAYLFVRARCASHIAVATTRRPGNIFYDFFFGRELNPRIGNMDLKSFFELRPGFIGWAIISLVMVLEDLQKNE--AFSPALLLYVALQFIYVADVLWNEERSLSTGDIPHKYFGFLLAFTNLAWIPFASSLPAYYLVHHHQELTAYWAAAICLLYLVGYVISRRAHTQKNAQSDSAGD----RGKPADSRSSP---VLGSWGRLRHPELLGELLMLLAWSLPCGFSHPLPYIPVVYSLVMLLHR 597

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BLAST of Lamin-B receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000385.1 (pep scaffold:Pmarinus_7.0:GL488468:1897:4392:1 gene:ENSPMAG00000000348.1 transcript:ENSPMAT00000000385.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 97.0561 bits (240), Expect = 1.182e-23
Identity = 55/146 (37.67%), Postives = 81/146 (55.48%), Query Frame = 3

Query: 1038 SLLFCAISQIIYCLDAVMFEG-DIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSG 1472
             L+   I  + Y  D V+ E  D+ ++  +  G  G+    G    VPF++ +    +  +   L     A+IA +  IG+ IYRSSN +KN FR+NP      HL+ I+ +HG  +LV GWWG LRHPNY GDII+ ++W+L  G
Sbjct:   19 PLILITIFHVTYTADLVLEEDFDLTTRESISTG-LGYAVVCGELTWVPFVYIIQAYFLLRHPQPLSWPGAAAIAALFFIGFWIYRSSNAEKNGFRKNPNHPDYAHLQKISTKHGKSLLVSGWWGWLRHPNYLGDIIMAVAWALPCG 163

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BLAST of Lamin-B receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000387.1 (pep scaffold:Pmarinus_7.0:GL488468:1954:4347:1 gene:ENSPMAG00000000348.1 transcript:ENSPMAT00000000387.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 91.6633 bits (226), Expect = 3.657e-22
Identity = 54/145 (37.24%), Postives = 81/145 (55.86%), Query Frame = 3

Query: 1041 LLFCAISQIIYCLDAVMFEG-DIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSG 1472
            L+   I  + Y  D V+ E  D+ ++  +  G  G+    G    VPF++ +    +  +   L     A+IA +  IG+ IYRSSN +KN FR+NP   H  + + I+ +HG  +LV GWWG LRHPNY GDII+ ++W+L  G
Sbjct:    1 LILITIFHVTYTADLVLEEDFDLTTRESISTG-LGYAVVCGELTWVPFVYIIQAYFLLRHPQPLSWPGAAAIAALFFIGFWIYRSSNAEKNGFRKNPN--HPDYARKISTKHGKSLLVSGWWGWLRHPNYLGDIIMAVAWALPCG 142

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BLAST of Lamin-B receptor vs. Ensembl Yeast
Match: ERG24 (C-14 sterol reductase; acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions [Source:SGD;Acc:S000005224])

HSP 1 Score: 165.622 bits (418), Expect = 1.096e-45
Identity = 114/383 (29.77%), Postives = 193/383 (50.39%), Query Frame = 3

Query:  534 LQYFTDGKNIGIVIC-WLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKT----LTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLT-----------EKI-KIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            L+Y+   + +  V C W   LA L  I  G+       + G ++ Y+ NG I+M  T+  +  + +  T       + +Y+N+  L   SIL +        + S++            EKI  +     N IY++ +GRE+N R   LD+K F E RPG   W+++N+  CL     +  K IN +L+     Q  Y  D V+ E  +++   +    FGF    G+  +VPF ++L  R + ++  +L    +  I  I  +G+ I+ S+N QK+ FRQ      L +LK+I  + G ++L  GWW   +H NYFGD +I LSW L +     + ++Y +YF   ++ R  +D+ KC +++G  W +Y + VPY++IP+V+
Sbjct:   63 LRYYLGNRELWTVYCLWYGILAVLDVILPGRVMKGVQLRDGSKLSYKING-IAMSTTLVLVLAIRWKLTDGQLPELQYLYENHVSLCIISILFSFFLATYCYVASFIPLIFKKNGNGKREKILALGGNSGNIIYDWFIGRELNPRLGPLDIKMFSELRPGMLLWLLINLS-CLHHHYLKTGK-INDALVLVNFLQGFYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLVPFTYSLQARYLSVSPVELGWVKVVGILAIMFLGFHIFHSANKQKSEFRQG----KLENLKSIQTKRGTKLLCDGWWAKSQHINYFGDWLISLSWCLATWFQTPLTYYYSLYFATLLLHRQQRDEHKCRLKYGENWEEYERKVPYKIIPYVY 438

[Close]

BLAST of Lamin-B receptor vs. Ensembl Yeast
Match: ERG4 (C-24(28) sterol reductase; catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol [Source:SGD;Acc:S000002980])

HSP 1 Score: 95.5153 bits (236), Expect = 2.187e-21
Identity = 81/271 (29.89%), Postives = 127/271 (46.86%), Query Frame = 3

Query:  870 NFIYNFIVGREINTRFFGLDLKFFYEFR-PGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLF---TLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQN--------------PYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            N +Y+F +G  +N R+  LDLK F+E R P FT + I  +  CLK  E   +  +   L    ++  +Y       E  I+    M   +FGF     N   VP+ +   TL       + +        S+ V+ L  Y  + ++N QKN+FR+               PY + L + K +   +G  +L+ GW+ L R  +Y  D    L W+L  G N    WF+P++FL+ +I R  +D  KC  ++G  W++Y K  PY  IP+VF
Sbjct:  207 NHLYDFFMGAPLNPRWGILDLKMFFEVRLPWFTLYFI-TLGACLKQWET--YGYVTPQLGVVMLAHWLYANACAKGEELIVPTWDMAYEKFGFMLIFWNIAGVPYTYCHCTLYLYYHDPSEYHWSTLYNVSLYVVLLCAYYFFDTANAQKNAFRKQMSGDKTGRKTFPFLPYQI-LKNPKYMVTSNGSYLLIDGWYTLARKIHYTADWTQSLVWALSCGFNSVFPWFFPVFFLVVLIHRAFRDQAKCKRKYGKDWDEYCKHCPYVFIPYVF 473

[Close]

BLAST of Lamin-B receptor vs. Ensembl Nematostella
Match: EDO31599 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXI1])

HSP 1 Score: 222.246 bits (565), Expect = 2.658e-66
Identity = 122/356 (34.27%), Postives = 196/356 (55.06%), Query Frame = 3

Query:  567 IVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLT-EKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            +   W++Y   L  +P G          G ++ YR N + +++ TI     LM  K +    VYDN+  LI ++IL +VV    L +K+      +       N IY+F +G ++N R    D KFF E RPG  GWM++N  FCL   E  ++ S++ ++L     Q IY  D ++FE  I+S   M++  FG+    G+   VPF+++L  R +  +   L    + SI  + ++GY+I+R SN+QK+ FRQ+P        +TI    G +++V GWWGL+RHPNY GDI++ ++WSL  G +  + WFYP+Y  + +I R  +D+   + ++G  W++Y + VPYR+ P VF
Sbjct:   73 VYAAWMLYQVLLYMLPFGNVIKGPQLADGSQLDYRINSLFALLGTIALFFALMANK-IPVTFVYDNFLSLITATILWSVVISVFLFVKAKRQGSGLSSGGNTGNAIYDFFMGHQLNPRIGNFDFKFFCEMRPGLLGWMMIN--FCLAVKESNDYGSLSPAMLLVCAFQFIYVADCLLFEASILSTIDMVHEGFGYMLAFGDLAFVPFMYSLQGRFLVDHRTHLHWAAIVSIVALKVVGYVIFRGSNLQKDYFRQHPEDPEFKDRETILTPSGKRLMVFGWWGLVRHPNYLGDILMAIAWSLPCGFSHAIPWFYPLYLTVLLIHREFRDEALNSHKYGKLWDEYCRRVPYRIFPKVF 425

[Close]

BLAST of Lamin-B receptor vs. Ensembl Nematostella
Match: EDO38405 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCZ5])

HSP 1 Score: 144.436 bits (363), Expect = 6.614e-38
Identity = 106/383 (27.68%), Postives = 186/383 (48.56%), Query Frame = 3

Query:  555 KNIGIVICWL-----MYLAALAHIPIGKTAYSTTKKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYL--TEKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINY---SLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINL--IGYIIYRSSNIQKNSFRQNPYSVHLCHL-----KTITNRHGHQ--------ILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
              +G+ + WL     +YLA    I  G    + T  G  + Y+ NG+ + I T      L Y   +   ++Y+ +  L+  + ++ ++    + +K++   T K    F   +F Y+F +G E N R   LD K F+  RPG   W ++N+      +  R+++ + Y   S+L   I Q +Y +D    E   +    + +  FGF+   G+ V +PF++TL  +A+ +    + +  +AS  ++ L   GY+I+R  N QK+ FR        C +     K +T  +           +L  GWWGL RH NY GD++ CL++    G    + +FY IY  + ++ R  +DD +C  ++G  W +Y K VPYR++P++F
Sbjct:   28 SGVGLFLTWLTLQLVLYLALPGRIATG----NPTPAGNILSYKCNGLNAWIFTHALFIALAYFDLMKMTVIYNYWGSLLVLANILGILLTAFVYVKAHYFPTHKEDRCFSG-SFFYDFYMGIEANPRIGNLDFKLFFNGRPGIVAWTLINL-----SMAARQYEQLGYVTNSMLLVNILQGMYVVDFFAHEAWYLRTIDIAHDHFGFYLAWGDCVWLPFMYTL--QAVYLVYHPVRLSWIASFVILALGISGYLIFRLVNSQKDYFRCQMKRTGSCEIWGEPAKYVTAEYTTSDGEVKTSWLLSSGWWGLSRHFNYVGDLMGCLAYCAACGTGHVLPYFYLIYMTVLLVHRSYRDDVRCREKYGKYWAEYTKLVPYRIVPYLF 398

[Close]

BLAST of Lamin-B receptor vs. Ensembl Medaka
Match: lbr (lamin B receptor [Source:NCBI gene;Acc:101159885])

HSP 1 Score: 225.713 bits (574), Expect = 1.650e-65
Identity = 117/365 (32.05%), Postives = 205/365 (56.16%), Query Frame = 3

Query:  549 DGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXX----XXKSYLTEKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            D + +G+V  W+++ A L  +P+GK +     + G  +KYR NG  +   +  ++A  +Y   L A + Y + +FL  ++    +  L  L           E++ +     N + +F  GRE+N R   LDLKFF E RPG  GW ++N+   L +++ +  ++ +Y ++   + Q++Y LD++  E  +++   +L+  FGF    G+ V VPF ++L    +  +   L I  LA+   + L+GY I+R SN +KN FR++P    L HLK+I    G  +LV GWWG++RHPNY GD+++ L+WSL  G +  + W Y I+F++ ++ R  +    C   +G+AW++Y + VPYR++P+++
Sbjct:  236 DPQAVGLVFLWILFQALLYVLPVGKLSEGVPLRSGQRLKYRTNGFFATAASAAAVAAAVY---LGADLTYIHSHFLQLAAASFLLSVLLGLFLYVRSGHAAPEELAVGGNSGNVVCDFSKGRELNPRIRNLDLKFFCEMRPGLIGWCLINLALALTEMKQQGLQAPSYPMILVTLFQLLYVLDSLWNEEAVLTSMDLLHEGFGFMLAFGDLVWVPFTYSLQAFYLVEHPSPLNIPVLAASVALQLVGYYIFRKSNSEKNRFRRDPSDPRLSHLKSIPTATGRSLLVSGWWGMVRHPNYLGDLMMALAWSLPCGFSHLLPWHYLIHFMVLLVHRDSRITTVCRRTYGSAWDEYCRTVPYRIVPYLY 597

[Close]

BLAST of Lamin-B receptor vs. Ensembl Medaka
Match: tm7sf2 (transmembrane 7 superfamily member 2 [Source:NCBI gene;Acc:101162861])

HSP 1 Score: 207.223 bits (526), Expect = 2.903e-60
Identity = 119/401 (29.68%), Postives = 210/401 (52.37%), Query Frame = 3

Query:  435 CCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTT-KKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAF--RPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            C  +F  +  +FL+       A +              D     +++ W+     L H+P+GK +     + G  +KY  NG+  + +++  L+ LM+        +++    L  S+I V+ +    L ++S+      +A      N +Y+F +GRE+N R    DLK+F E RPG  GW+++N    +K++E R   S+  +++     Q++Y  DA+  E  +++   +++  FGF    G+   VPF + L    + ++   L       I ++N +GY I+R SN QKN FR++P    +  L+TI    G ++LV GWWG +RHPNY GD+++ L+WSL  G +  + +FY IYF + ++ R  +D+R+C  ++G AW+ Y + VPYR+ PF++
Sbjct:   28 CIPIFLPLTVLFLIGLSRSPEASVLQWPPSLPSYNQLLDPLAPVLLLGWIALHILLYHLPLGKVSEGLVLRDGTRLKYPINGIHGLCVSVALLSLLMWLGA-PLGYLFELLLPLAASAIAVSFLLSIYLYIRSFWAPSHALALGGNTGNPLYDFFIGRELNPRIGNFDLKYFCELRPGLIGWVVINFGMLMKEVELRGSPSL--AMILVNSFQLLYVADALWNEEAVLTTMDIVHDGFGFMLVFGDLAWVPFTYGLQAAFLVVHPQTLTWLKAVFILLLNGMGYYIFRKSNSQKNQFRRDPTHPSVTGLETIATATGKRLLVSGWWGFVRHPNYLGDLLMALAWSLPCGFSHLLPYFYVIYFTVLLVHREARDERQCKAKYGLAWDAYCRRVPYRIFPFIY 425

[Close]

BLAST of Lamin-B receptor vs. Ensembl Medaka
Match: tm7sf2 (transmembrane 7 superfamily member 2 [Source:NCBI gene;Acc:101162861])

HSP 1 Score: 191.045 bits (484), Expect = 3.536e-54
Identity = 117/407 (28.75%), Postives = 208/407 (51.11%), Query Frame = 3

Query:  435 CCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTTKKGIEVK-----YRF--NGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAF--RPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            C  +F  +  +FL+       A +              D     +++ W+     L H+P+GK       +   ++     Y F   G+  + +++  L+ LM+        +++    L  S+I V+ +    L ++S+      +A      N +Y+F +GRE+N R    DLK+F E RPG  GW+++N    +K++E R   S+  +++     Q++Y  DA+  E  +++   +++  FGF    G+   VPF + L    + ++   L       I ++N +GY I+R SN QKN FR++P    +  L+TI    G ++LV GWWG +RHPNY GD+++ L+WSL  G +  + +FY IYF + ++ R  +D+R+C  ++G AW+ Y + VPYR+ PF++
Sbjct:   28 CIPIFLPLTVLFLIGLSRSPEASVLQWPPSLPSYNQLLDPLAPVLLLGWIALHILLYHLPLGKVRNIVLCRLFLLRRHICCYLFLPQGIHGLCVSVALLSLLMWLGA-PLGYLFELLLPLAASAIAVSFLLSIYLYIRSFWAPSHALALGGNTGNPLYDFFIGRELNPRIGNFDLKYFCELRPGLIGWVVINFGMLMKEVELRGSPSL--AMILVNSFQLLYVADALWNEEAVLTTMDIVHDGFGFMLVFGDLAWVPFTYGLQAAFLVVHPQTLTWLKAVFILLLNGMGYYIFRKSNSQKNQFRRDPTHPSVTGLETIATATGKRLLVSGWWGFVRHPNYLGDLLMALAWSLPCGFSHLLPYFYVIYFTVLLVHREARDERQCKAKYGLAWDAYCRRVPYRIFPFIY 431

[Close]

BLAST of Lamin-B receptor vs. Ensembl Medaka
Match: dhcr7 (7-dehydrocholesterol reductase [Source:NCBI gene;Acc:101175471])

HSP 1 Score: 139.428 bits (350), Expect = 5.714e-35
Identity = 100/346 (28.90%), Postives = 171/346 (49.42%), Query Frame = 3

Query:  633 STTKKGIEVKYRFNGVISMIIT-ITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYL--TEKIKIAFRPINFIYNFIVGREINTRFF-GLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQN----------PYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            + T  G+  KY  NG+   +IT     A   Y    +  +++DN+  L+  + L+         +K+Y+  T      F   N  YN+++G E N R     D K F+  RPG   W ++N+ +  K  E   + ++  S++   I Q IY LD    E   +    + +  FG++   G+ V +P+L+TL    +  +  QL      ++ ++ L+GY I+RS+N QK+ FR++          P  +   +       H  ++L  G+WG+ RH NY GD++  L++    GL   + +FY +Y  + ++ RCV+D+ +C+ ++G  W  Y  AVPYRLIP VF
Sbjct:  176 ARTPAGLINKYEINGLQCWLITHALWFANARYFHWFSPTIIFDNWIPLMWCANLLGYAVSTFAFVKAYIFPTNPEDCKFTG-NVFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYMSKQQE--LYGTVTNSMILVNILQGIYVLDFFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSDASALAVLLLGLLGYYIFRSTNHQKDLFRRHDGSCTIWGRKPSFIECSYRSADGGLHRSKLLTSGFWGVARHFNYTGDLMGSLAYCAACGLGHILPYFYIVYMTILLVHRCVRDEHRCSSKYGKDWKRYTDAVPYRLIPGVF 518

[Close]

BLAST of Lamin-B receptor vs. Planmine SMEST
Match: SMESG000042131.1 (SMESG000042131.1)

HSP 1 Score: 974.541 bits (2518), Expect = 0.000e+0
Identity = 513/515 (99.61%), Postives = 513/515 (99.61%), Query Frame = 3

Query:   84 MVEKYXXXXXXXXXXXXXXXXXXXXXIVLSRTKKSMEVSEKPTSSNLAYVARRVTRRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKVKVLSKFQIYFKSMKSIMFCCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTTKKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSXXXXXXXXXXXXXKSYLTEKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 1628
            MVEKYTRKRSKSAPRRRSRSTSKSKPIVLSRTKKSMEVSEKPTSSNLAYVARRVTRRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKVKVLSKFQIYFKSMKSIMFCCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTTKKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSILVAVVFLFILLLKSYLTEKIK AFRPINFIYNFIVGREINTR FGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF
Sbjct:    1 MVEKYTRKRSKSAPRRRSRSTSKSKPIVLSRTKKSMEVSEKPTSSNLAYVARRVTRRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKVKVLSKFQIYFKSMKSIMFCCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIKLQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTTKKGIEVKYRFNGVISMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSILVAVVFLFILLLKSYLTEKIKKAFRPINFIYNFIVGREINTRCFGLDLKFFYEFRPGFTGWMILNIIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNGQFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYIIYRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFGDIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWNDYRKAVPYRLIPFVF 515

The following BLAST results are available for this feature:

BLAST of Lamin-B receptor vs. Ensembl Human
BLAST of Lamin-B receptor vs. Ensembl Celegans
BLAST of Lamin-B receptor vs. Ensembl Fly
BLAST of Lamin-B receptor vs. Ensembl Zebrafish
BLAST of Lamin-B receptor vs. Ensembl Xenopus
BLAST of Lamin-B receptor vs. Ensembl Mouse
BLAST of Lamin-B receptor vs. UniProt/SwissProt
BLAST of Lamin-B receptor vs. TrEMBL
BLAST of Lamin-B receptor vs. Ensembl Cavefish
BLAST of Lamin-B receptor vs. Ensembl Sea Lamprey
BLAST of Lamin-B receptor vs. Ensembl Yeast
BLAST of Lamin-B receptor vs. Ensembl Nematostella
BLAST of Lamin-B receptor vs. Ensembl Medaka
BLAST of Lamin-B receptor vs. Planmine SMEST

BLAST of Lamin-B receptor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
LBR	8.873e-62	32.59	lamin B receptor [Source:HGNC Symbol;Acc:HGNC:6518...	[more]
LBR	8.873e-62	32.59	lamin B receptor [Source:HGNC Symbol;Acc:HGNC:6518...	[more]
TM7SF2	7.544e-57	36.36	transmembrane 7 superfamily member 2 [Source:HGNC ...	[more]
TM7SF2	6.974e-42	37.37	transmembrane 7 superfamily member 2 [Source:HGNC ...	[more]
TM7SF2	9.700e-42	31.62	transmembrane 7 superfamily member 2 [Source:HGNC ...	[more]

BLAST of Lamin-B receptor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
dhcr-7	3.429e-12	21.21	DeHydroCholesterol Reductase; Sterol reductase [S...	[more]
dhcr-7	3.429e-12	21.21	DeHydroCholesterol Reductase; Sterol reductase [S...	[more]

BLAST of Lamin-B receptor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
LBR	4.740e-12	27.65	gene:FBgn0034657 transcript:FBtr0071712	[more]
LBR	4.740e-12	27.65	gene:FBgn0034657 transcript:FBtr0071711	[more]
LBR	5.053e-12	27.65	gene:FBgn0034657 transcript:FBtr0071713	[more]

BLAST of Lamin-B receptor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lbr	2.200e-66	29.81	lamin B receptor [Source:ZFIN;Acc:ZDB-GENE-030804-...	[more]
lbr	2.200e-66	29.81	lamin B receptor [Source:ZFIN;Acc:ZDB-GENE-030804-...	[more]
tm7sf2	1.525e-60	30.42	transmembrane 7 superfamily member 2 [Source:ZFIN;...	[more]
tm7sf2	1.525e-60	30.42	transmembrane 7 superfamily member 2 [Source:ZFIN;...	[more]
tm7sf2	1.525e-60	30.42	transmembrane 7 superfamily member 2 [Source:ZFIN;...	[more]

BLAST of Lamin-B receptor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rp9	8.956e-68	33.67	retinitis pigmentosa 9 (autosomal dominant) [Sourc...	[more]
rp9	1.427e-67	33.67	retinitis pigmentosa 9 (autosomal dominant) [Sourc...	[more]
rp9	1.919e-66	33.67	retinitis pigmentosa 9 (autosomal dominant) [Sourc...	[more]
rp9	3.756e-66	33.16	retinitis pigmentosa 9 (autosomal dominant) [Sourc...	[more]
lbr	5.191e-64	31.39	lamin B receptor [Source:NCBI gene;Acc:100145693]	[more]

BLAST of Lamin-B receptor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Lbr	1.583e-64	32.77	lamin B receptor [Source:MGI Symbol;Acc:MGI:213828...	[more]
Tm7sf2	5.330e-58	36.76	transmembrane 7 superfamily member 2 [Source:MGI S...	[more]
Tm7sf2	3.427e-43	32.03	transmembrane 7 superfamily member 2 [Source:MGI S...	[more]
Tm7sf2	1.573e-42	37.20	transmembrane 7 superfamily member 2 [Source:MGI S...	[more]
Dhcr7	1.349e-35	28.90	7-dehydrocholesterol reductase [Source:MGI Symbol;...	[more]

BLAST of Lamin-B receptor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q3U9G9\|LBR_MOUSE	1.108e-63	32.77	Delta(14)-sterol reductase LBR OS=Mus musculus OX=...	[more]
sp\|O08984\|LBR_RAT	2.135e-62	32.15	Delta(14)-sterol reductase LBR OS=Rattus norvegicu...	[more]
sp\|Q14739\|LBR_HUMAN	4.261e-61	32.59	Delta(14)-sterol reductase LBR OS=Homo sapiens OX=...	[more]
sp\|Q5R7H4\|LBR_PONAB	1.310e-60	32.31	Delta(14)-sterol reductase LBR OS=Pongo abelii OX=...	[more]
sp\|P23913\|LBR_CHICK	2.150e-57	31.32	Delta(14)-sterol reductase LBR OS=Gallus gallus OX...	[more]

BLAST of Lamin-B receptor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
V3ZS14	1.928e-74	36.91	Uncharacterized protein OS=Lottia gigantea OX=2251...	[more]
A0A1S3HT82	8.438e-74	34.05	delta(14)-sterol reductase isoform X3 OS=Lingula u...	[more]
A0A1S3HT59	1.186e-73	34.05	delta(14)-sterol reductase isoform X2 OS=Lingula u...	[more]
A0A3S0ZQQ3	4.198e-73	32.84	Uncharacterized protein OS=Elysia chlorotica OX=18...	[more]
A0A1S3HT56	5.190e-73	34.05	delta(14)-sterol reductase isoform X1 OS=Lingula u...	[more]

BLAST of Lamin-B receptor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lbr	3.735e-63	30.47	lamin-B receptor [Source:NCBI gene;Acc:103032852]	[more]
tm7sf2	3.028e-62	34.14	transmembrane 7 superfamily member 2 [Source:ZFIN;...	[more]
si:ch1073-429i10.1	2.774e-41	27.70	delta(14)-sterol reductase-like [Source:NCBI gene;...	[more]
si:ch1073-429i10.1	4.388e-41	27.70	delta(14)-sterol reductase-like [Source:NCBI gene;...	[more]
dhcr7	4.101e-39	28.16	7-dehydrocholesterol reductase [Source:NCBI gene;A...	[more]

BLAST of Lamin-B receptor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4


Match Name	E-value	Identity	Description
ENSPMAT00000002700.1	3.025e-37	29.25	pep scaffold:Pmarinus_7.0:GL480753:6556:12779:-1 g...	[more]
ENSPMAT00000000142.1	2.013e-33	29.66	pep scaffold:Pmarinus_7.0:GL476617:408941:423101:1...	[more]
ENSPMAT00000000385.1	1.182e-23	37.67	pep scaffold:Pmarinus_7.0:GL488468:1897:4392:1 gen...	[more]
ENSPMAT00000000387.1	3.657e-22	37.24	pep scaffold:Pmarinus_7.0:GL488468:1954:4347:1 gen...	[more]

BLAST of Lamin-B receptor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
ERG24	1.096e-45	29.77	C-14 sterol reductase; acts in ergosterol biosynth...	[more]
ERG4	2.187e-21	29.89	C-24(28) sterol reductase; catalyzes the final ste...	[more]

BLAST of Lamin-B receptor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO31599	2.658e-66	34.27	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38405	6.614e-38	27.68	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Lamin-B receptor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4


Match Name	E-value	Identity	Description
lbr	1.650e-65	32.05	lamin B receptor [Source:NCBI gene;Acc:101159885]	[more]
tm7sf2	2.903e-60	29.68	transmembrane 7 superfamily member 2 [Source:NCBI ...	[more]
tm7sf2	3.536e-54	28.75	transmembrane 7 superfamily member 2 [Source:NCBI ...	[more]
dhcr7	5.714e-35	28.90	7-dehydrocholesterol reductase [Source:NCBI gene;A...	[more]

BLAST of Lamin-B receptor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000042131.1	0.000e+0	99.61	SMESG000042131.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30030198 ID=SMED30030198|Name=Lamin-B receptor|organism=Schmidtea mediterranea sexual|type=transcript|length=1808bp
GTTTGTTTTAATAAATGCCTTAGTTTCTTTATCCCATTATGAAACAAAGC
TTGAATTCTGCAGTTTAAGTTAGGCGTTATTAAATGGTAGAAAAATACAC
AAGAAAGCGTTCTAAAAGTGCTCCTCGGAGAAGATCTCGTTCAACTTCAA
AATCTAAACCTATAGTTTTATCCAGGACAAAGAAGTCGATGGAAGTCAGT
GAAAAACCCACCTCCTCTAACCTTGCATATGTAGCAAGGCGCGTTACTCG
TCGATCTAAGCAAATTGAATCTAAATTTTTGGGAAATGACGATAATATGG
AAATAGAAACTGTAACTGAAAGTAAAAAACCTCAGTTGTTAGATAATGGA
AACACAGAAAACTTTGATAAGCCAAAAGTCAAAGTTCTATCAAAATTTCA
AATTTATTTCAAATCAATGAAGTCTATTATGTTTTGTTGTATGGTTTTCT
CTTTAATTCCAGCCGTGTTTCTATTAAATAAAATGTCTGAAGATGGTGCC
AAAATAAGACATATCAGTTTCAAAGAAATTAAATTACAATATTTCACAGA
TGGCAAAAATATAGGAATTGTCATTTGTTGGTTAATGTATTTAGCAGCCT
TAGCTCACATCCCCATTGGAAAAACAGCATATTCTACAACTAAAAAAGGC
ATTGAAGTTAAATATAGATTTAATGGTGTTATTTCCATGATAATAACCAT
AACTAGTTTAGCAGGTCTTATGTATACCAAAACTCTCACGGCAAAAATGG
TTTACGATAATTATTATTTTTTAATTGGGAGTTCTATTTTGGTTGCAGTG
GTCTTTTTATTTATATTATTGTTGAAATCATATTTAACTGAAAAAATCAA
GATAGCGTTTAGACCTATAAATTTTATTTATAATTTCATCGTTGGTCGTG
AAATTAATACAAGATTTTTTGGGTTAGATCTGAAATTTTTTTATGAATTC
CGACCCGGTTTCACTGGTTGGATGATATTAAATATTATTTTCTGTCTGAA
GGATTTAGAAGATCGTGAGTTTAAATCAATTAATTATTCACTACTATTTT
GTGCAATAAGTCAAATAATATATTGTCTCGATGCTGTGATGTTCGAGGGA
GATATTATTTCTAAACCGTTTATGTTAAACGGACAATTTGGTTTCTTTCA
CTGCCTTGGAAATCAAGTCATAGTTCCATTTTTGTTTACTTTGACCACTC
GAGCTATACAAATTAATAACTTCCAACTGCCTATCAAATGTTTAGCGAGT
ATTGCCGTCATTAATCTGATTGGATACATTATTTATCGATCATCAAATAT
ACAGAAAAATAGTTTCCGTCAAAATCCCTACAGTGTTCACCTATGCCATT
TAAAAACAATTACAAATCGTCATGGTCATCAAATACTCGTTGGTGGATGG
TGGGGATTATTGAGACATCCGAATTATTTTGGTGATATAATTATCTGTTT
ATCTTGGTCTCTATATTCCGGGCTAAATTTCGGTGTGTGCTGGTTCTATC
CAATATATTTTTTACTTTTTATAATTACTCGTTGCGTTCAAGATGATCGG
AAATGTGCGGTTGAGCACGGCACAGCATGGAATGATTATCGCAAGGCTGT
GCCGTATCGATTAATTCCTTTTGTATTTTAAATTGTATTTAATGTTTTAT
GTATTGATTGGGCATGCTTATTCATTTCTTTATGGCAGCTGTTTTGATTG
AATTTATGTCCGTATATTTTTTATGTAATTCGATTTGTAATTTATATATT
TAAATTTTTCACTATTTATGCTTGGTTGTGAATTTCATGAGTTGGTGAGA
TCGGAAGA

protein sequence of SMED30030198-orf-1

>SMED30030198-orf-1 ID=SMED30030198-orf-1|Name=SMED30030198-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=516bp
MVEKYTRKRSKSAPRRRSRSTSKSKPIVLSRTKKSMEVSEKPTSSNLAYV
ARRVTRRSKQIESKFLGNDDNMEIETVTESKKPQLLDNGNTENFDKPKVK
VLSKFQIYFKSMKSIMFCCMVFSLIPAVFLLNKMSEDGAKIRHISFKEIK
LQYFTDGKNIGIVICWLMYLAALAHIPIGKTAYSTTKKGIEVKYRFNGVI
SMIITITSLAGLMYTKTLTAKMVYDNYYFLIGSSILVAVVFLFILLLKSY
LTEKIKIAFRPINFIYNFIVGREINTRFFGLDLKFFYEFRPGFTGWMILN
IIFCLKDLEDREFKSINYSLLFCAISQIIYCLDAVMFEGDIISKPFMLNG
QFGFFHCLGNQVIVPFLFTLTTRAIQINNFQLPIKCLASIAVINLIGYII
YRSSNIQKNSFRQNPYSVHLCHLKTITNRHGHQILVGGWWGLLRHPNYFG
DIIICLSWSLYSGLNFGVCWFYPIYFLLFIITRCVQDDRKCAVEHGTAWN
DYRKAVPYRLIPFVF*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **biological process**
Term	Definition
GO:0016126	sterol biosynthetic process
GO:0055114	oxidation-reduction process

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000026	gut
PLANA:0000099	neuron
PLANA:0000101	muscle cell
PLANA:0000429	neoblast
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell
PLANA:0002142	parenchyma

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **INTERPRO**
Term	Definition
IPR001171	Ergosterol_biosynth_ERG4_ERG24

Vocabulary: **molecular function**
Term	Definition
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0046872	metal ion binding

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001171	Ergosterol biosynthesis ERG4/ERG24	PFAM	PF01222	ERG4_ERG24	coord: 106..515 e-value: 6.1E-77 score: 259.2
None	No IPR available	GENE3D	G3DSA:1.20.120.1630		coord: 318..515 e-value: 5.2E-11 score: 44.8
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..42
None	No IPR available	PANTHER	PTHR21257:SF17	DELTA(14)-STEROL REDUCTASE	coord: 108..515
None	No IPR available	PANTHER	PTHR21257	STEROL REDUCTASE/LAMIN B RECEPTOR	coord: 108..515
None	No IPR available	TMHMM	TMhelix		coord: 352..370
None	No IPR available	TMHMM	TMhelix		coord: 382..401
None	No IPR available	TMHMM	TMhelix		coord: 315..337
None	No IPR available	TMHMM	TMhelix		coord: 114..131
None	No IPR available	TMHMM	TMhelix		coord: 192..214
None	No IPR available	TMHMM	TMhelix		coord: 458..480
None	No IPR available	TMHMM	TMhelix		coord: 229..251
None	No IPR available	TMHMM	TMhelix		coord: 160..179