WD repeat-containing protein 55

Overview


Name	WD repeat-containing protein 55
Smed ID	SMED30030189
Length (bp)	1306

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of WD repeat-containing protein 55 (SMED30030189) t-SNE clustered cells

Violin plots show distribution of expression levels for WD repeat-containing protein 55 (SMED30030189) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of WD repeat-containing protein 55 (SMED30030189) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for WD repeat-containing protein 55 (SMED30030189) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30030189

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
X1 cell	SMED30030189	SMESG000072415.1	SmedASXL_007684	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30030189	SMESG000072415.1	SmedASXL_007684	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015

Note: Hover over icons to view figure legend

Homology

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BLAST of WD repeat-containing protein 55 vs. Ensembl Human
Match: WDR55 (WD repeat domain 55 [Source:HGNC Symbol;Acc:HGNC:25971])

HSP 1 Score: 132.494 bits (332), Expect = 4.859e-34
Identity = 84/289 (29.07%), Postives = 142/289 (49.13%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWHKNLSR-LAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            ++ + P+ I L+  A G+A   FHP +D+L  G V+G V +  Y C +   +EL+    H    R +A S+ G +++T S    I   D E G+       AH   I++++        + DD+  +  WD R++ P+ +M                  +  Y++    + LD   + L  A  DG L   N K+R+ EL SE  +    S+   K   K+   + EG I +FNWN FG  SDRF +  +++ I+ M+ + E+++  G+  G I+AV++LPN V+  +G
Sbjct:   27 RIRDTPEDIVLEAPASGLA---FHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQRKEGPLMDMR----------------QHEEYIAD---MALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFAL--RAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVG 291

[Close]

BLAST of WD repeat-containing protein 55 vs. Ensembl Human
Match: WDR55 (WD repeat domain 55 [Source:HGNC Symbol;Acc:HGNC:25971])

HSP 1 Score: 84.7297 bits (208), Expect = 2.624e-18
Identity = 45/133 (33.83%), Postives = 73/133 (54.89%), Query Frame = 1

Query:  472 MSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            M  +  Y++    + LD   + L  A  DG L   N K+R+ EL SE  +    S+   K   K+   + EG I +FNWN FG  SDRF +  +++ I+ M+ + E+++  G+  G I+AV++LPN V+  +G
Sbjct:    3 MRQHEEYIAD---MALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFAL--RAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVG 130

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BLAST of WD repeat-containing protein 55 vs. Ensembl Celegans
Match: Y44F5A.1 (3E324 [Source:UniProtKB/TrEMBL;Acc:G5EEZ4])

HSP 1 Score: 53.1434 bits (126), Expect = 2.130e-7
Identity = 64/223 (28.70%), Postives = 103/223 (46.19%), Query Frame = 1

Query:  100 LVIGTVEGRVRIYDCNKSSPEELFRKKWH---KNLSR---LAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAI--IYQTA---KTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDR 735
            LV+G V+G +R YD  +   EE F++ W    K+  R   L   K     +T +   C+   D + GK     L  H+   +AI  +  TA   +   +AD+S  +K W+    DP           E   E+A +         +N L +D    +L A   DGTL   + +K K+++RSE L  S    V   N+S + +  ++G + +FN N++GNL +R
Sbjct:   21 LVVGFVDGSIRFYDTQQH--EEEFQEIWKFQTKSSIRGVDLDEHKKRVYAVTKNRSLCV--FDIDTGKRVRCILKCHRSVPTAICTLPPTALKSQQLATADESGEVKTWN---LDP-----------EVASENANIRKWQEQDEDINDLKVDVKS-NLLATSSDGTLGAYDLRKAKLKMRSE-LMHSELYSVCGTNRS-VYVGGEDGYVEVFNLNEYGNLLER 222

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BLAST of WD repeat-containing protein 55 vs. Ensembl Fly
Match: CG14722 (gene:FBgn0037943 transcript:FBtr0082431)

HSP 1 Score: 110.923 bits (276), Expect = 4.196e-26
Identity = 88/343 (25.66%), Postives = 151/343 (44.02%), Query Frame = 1

Query:   28 PQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRIYDCNKSSPEELFRKKWHKNLSR-LAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCGDCMTLDTNFTHNIVASGCPESNIVCFFSTEKATEEFSILLQDRSENKRK 1053
            P  IKL+   D I ++ FHP +DI+ + T+ G V +Y+ +  + + L   + H    R +  ++ G  +LT S   C+   D E  K       AH + I+ +       + S DD+  +K WD R ++ + E+       E +D+             +  L  ++  + L A   DG L T N   RK+ ++SE        +  ++  SKL + T +G +  +NW QFG   D +P +K    I  MI + + +  V    G I+A  + P   L  +G    P+         +LD N +  ++AS    +N V F++  K  E+F  +  +   N  K
Sbjct:  150 PPEIKLE---DFITDICFHPDRDIIALATIIGDVHLYEYDNEANKLLRTIEVHSKACRDVEFTEDGRFLLTCSKDKCVMVTDMETEKLKKLYETAHDDAINTLHVLNENLFASGDDAGTVKLWDLRTKNAIFELK------ELEDQ-------------ITQLTTNEQSKLLLATSADGYLTTFNISARKMYVQSEPYEEELNCMGVYRGDSKLVVGTSKGRLYTYNWGQFGYHCDMYPGIK--SPISLMIPITDRIACVAGEDGNIRACHIAPYRNLGVVGQHNMPI--------ESLDVNASGELIASSS-HNNDVRFWNV-KYFEDFGDIKYNEKHNAYK 458

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BLAST of WD repeat-containing protein 55 vs. Ensembl Zebrafish
Match: wdr55 (WD repeat domain 55 [Source:NCBI gene;Acc:445394])

HSP 1 Score: 132.109 bits (331), Expect = 1.757e-34
Identity = 95/339 (28.02%), Postives = 158/339 (46.61%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWH-KNLSRLAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCGDCMTLDTNFTHNIVASGCPESNIVCFFSTEKATEEFSI 1020
            K+ E P+ IKL+   + IA   FHPK+DIL  G ++G + +  Y C +   +EL+    H K+  ++  S  G ++ + S    I   D E GK       AH+  I+A++      + + DD   LK WD R+     ++                 H+  Y+S +    +D   R L  +  DGTL   N K+R+ EL SE       S+   K   K+   + EG I IFNWN FG  SDRF V  +++ ++ ++ + ++++   +  G I+A+++LPN V+  IG Q      E    C   DT+F      + C    ++ F+      +E ++
Sbjct:   24 KIRETPEDIKLEAIVNTIA---FHPKQDILAAGDIDGDIYLFSYSCTEGENKELWSSGHHLKSCRKVLFSSDGQKLFSVSKDKAIHIMDVEAGKLETRIPKAHKAPINAMLLIDENIFATGDDEGTLKVWDMRKGTSFMDLK----------------HHEDYISDIT---IDQAKRTLLTSSGDGTLGVFNIKRRRFELLSEIQNGDLTSVSIMKRGRKVVCGSGEGTIYIFNWNGFGATSDRFAV--QAESVDCIVPITDSILCAASTDGVIRAINILPNRVVGSIG-QHVGEAIEEIARCR--DTHFL-----ASCAHDELIKFWDISSLPDEKTV 330

[Close]

BLAST of WD repeat-containing protein 55 vs. Ensembl Zebrafish
Match: wdr55 (WD repeat domain 55 [Source:NCBI gene;Acc:445394])

HSP 1 Score: 132.494 bits (332), Expect = 3.429e-34
Identity = 86/289 (29.76%), Postives = 141/289 (48.79%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWH-KNLSRLAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            K+ E P+ IKL+   + IA   FHPK+DIL  G ++G + +  Y C +   +EL+    H K+  ++  S  G ++ + S    I   D E GK       AH+  I+A++      + + DD   LK WD R+     ++                 H+  Y+S +    +D   R L  +  DGTL   N K+R+ EL SE       S+   K   K+   + EG I IFNWN FG  SDRF V  +++ ++ ++ + ++++   +  G I+A+++LPN V+  IG
Sbjct:   24 KIRETPEDIKLEAIVNTIA---FHPKQDILAAGDIDGDIYLFSYSCTEGENKELWSSGHHLKSCRKVLFSSDGQKLFSVSKDKAIHIMDVEAGKLETRIPKAHKAPINAMLLIDENIFATGDDEGTLKVWDMRKGTSFMDLK----------------HHEDYISDI---TIDQAKRTLLTSSGDGTLGVFNIKRRRFELLSEIQNGDLTSVSIMKRGRKVVCGSGEGTIYIFNWNGFGATSDRFAV--QAESVDCIVPITDSILCAASTDGVIRAINILPNRVVGSIG 288

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BLAST of WD repeat-containing protein 55 vs. Ensembl Xenopus
Match: selp (selectin P [Source:Xenbase;Acc:XB-GENE-482807])

HSP 1 Score: 132.88 bits (333), Expect = 3.733e-34
Identity = 87/289 (30.10%), Postives = 141/289 (48.79%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRIYD--CNKSSPEELFRKKWH-KNLSRLAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            ++ + P+ I  +   + IA   FHP +DIL  G V+G V +Y   C +S  +EL+    H K+    A +  G ++ T S    I     E GK       AH   ++ ++      + + DD+ +LK WD R+     EM                 ++  Y+S    + +D+N + L  A  DGT+   N K+R+ EL SE  +    S+   K   K+   + EG I +FNWN FG  SDRF V  K++ I+ M+ + +N+V  G+  G I+A+++LPN V+  +G
Sbjct:   36 RLRDTPEDILFEAAVNTIA---FHPSQDILAAGDVDGDVFVYSYSCWESGNKELWSSGHHLKSCRDSAFTSDGQQLFTVSKDKAIHILSMEEGKLIKRIPKAHDSPLNCLLLIDENLFATGDDNGMLKVWDLRRDTSFMEMK----------------NHEEYISD---MAIDENKKMLLTASGDGTMGVFNIKRRRFELLSEYQSGDLTSVAIMKRGKKVVCGSSEGTIYLFNWNGFGATSDRFAV--KAESIDCMVPITDNIVCTGSMDGVIRAINILPNRVVGTVG 300

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BLAST of WD repeat-containing protein 55 vs. Ensembl Mouse
Match: Wdr55 (WD repeat domain 55 [Source:MGI Symbol;Acc:MGI:1915186])

HSP 1 Score: 135.576 bits (340), Expect = 2.974e-35
Identity = 84/289 (29.07%), Postives = 143/289 (49.48%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWHKNLSRLAV-SKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            ++ + P+ I L+  A G+A   FHP +D+L  G V+G V +  Y C +   +EL+    H    R  V S+ G +++T S    I   D E G+       AH   I++++       ++ DD+  ++ WD R++ P+ +M                  +  Y++    + LD   + L  A  DG L   N K+R+ EL SE  +    S+   K   K+   + EG I +FNWN FG  SDRF +  +++ I+ ++ + EN++  G+  G I+AV++LPN V+  +G
Sbjct:   28 RIRDTPEDIVLEAPASGLA---FHPTRDLLAAGDVDGDVFVFAYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERRISKAHSAPINSVLLVDENALVTGDDTGGIRLWDQRKEGPLMDMR----------------QHEEYIAD---MALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGFGATSDRFAL--RAESIDCIVPVTENLLCTGSTDGIIRAVNILPNRVVGTVG 292

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BLAST of WD repeat-containing protein 55 vs. UniProt/SwissProt
Match: sp|A1L112|WDR55_RAT (WD repeat-containing protein 55 OS=Rattus norvegicus OX=10116 GN=Wdr55 PE=2 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 4.358e-35
Identity = 85/289 (29.41%), Postives = 143/289 (49.48%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWHKNLSRLAV-SKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            ++ + P+ I L+  A G+A   FHP +D+L  G V+G V +  Y C +   +EL+    H    R  V S+ G +++T S    I   D E G+       AH   I++++       ++ DD+  ++ WD R++ P+ +M                  +  Y++    + LD   + L  A  DG L   N K+R+ EL SE  +    S+   K   K+   + EG I +FNWN FG  SDRF +  +++ I+ M+ + EN++  G+  G I+AV++LPN V+  +G
Sbjct:   27 RIRDTPEDIVLEAPASGLA---FHPTRDLLAAGDVDGDVFVFAYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHVLDVEQGQLERRISKAHSAPINSLLLVDENVLVTGDDTGGIRLWDQRKEGPLMDMR----------------QHEEYIAD---MALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGFGATSDRFAL--RAESIDCMVPVTENLLCTGSTDGIIRAVNILPNRVVGTVG 291

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BLAST of WD repeat-containing protein 55 vs. UniProt/SwissProt
Match: sp|Q58DT8|WDR55_BOVIN (WD repeat-containing protein 55 OS=Bos taurus OX=9913 GN=WDR55 PE=2 SV=1)

HSP 1 Score: 136.346 bits (342), Expect = 7.720e-35
Identity = 89/314 (28.34%), Postives = 151/314 (48.09%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWHKNLSRLAV-SKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQ-EFPVGNEGCGDCMTLDTNFTHN 942
            ++ + P+ I L+  A G+A   FHP +D+L  G V+G V +  Y C +   +EL+    H    R  V S+ G +++T S    I   D E G+       AH   I++++        + DD+  ++ WD R++ P+ +M                  +  Y++    + LD + + L  A  DG L   N K+R+ EL SE  +    S+   K   K+   + EG I +FNW+ FG  SDRF +  +++ I+ M+ + E+++  G+  G I+AV++LPN V+  +G   E PV N     C     +  H+
Sbjct:   27 RIRDTPEDIVLEAPASGLA---FHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHFLDVELGRLERRISKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMR----------------QHEEYIAD---MALDPDKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVTLMKYGRKVACGSSEGTIYLFNWDGFGATSDRFAL--RAESIDCMVPVTESLLCAGSTDGVIRAVNILPNRVVGSVGQHAEEPVENLALSHCGCFLASSGHD 316

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BLAST of WD repeat-containing protein 55 vs. UniProt/SwissProt
Match: sp|Q5R9T6|WDR55_PONAB (WD repeat-containing protein 55 OS=Pongo abelii OX=9601 GN=WDR55 PE=2 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 1.402e-34
Identity = 89/314 (28.34%), Postives = 149/314 (47.45%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWHKNLSR-LAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEF-PVGNEGCGDCMTLDTNFTHN 942
            ++ + P+ I L+  A G+A   FHP +D+L  G V+G V +  Y C +   +EL+    H    R +A S+ G +++T S    I   D E G+       AH   I++++        + DD   ++ WD R++ P+ +M                  +  Y++    + LD   + L  A  DG L   N K+R+ EL SE  +    S+   K   K+   + EG I +FNWN FG  SDRF +  +++ I+ M+ + E+++  G+  G I+AV++LPN V+  +G     PVG      C     +  H+
Sbjct:   27 RIRDTPEDIVLEAPASGLA---FHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLVTVSKDKAIHVLDVEQGRLERRISKAHGAPINSLLLVDENVLATGDDMGGIRLWDQRKEGPLMDMR----------------QHEEYIAD---MALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVTLMKCGKKVACGSSEGTIYLFNWNGFGATSDRFAL--RAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVGQHTGEPVGELALSHCGRFLASSGHD 316

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BLAST of WD repeat-containing protein 55 vs. UniProt/SwissProt
Match: sp|Q9CX97|WDR55_MOUSE (WD repeat-containing protein 55 OS=Mus musculus OX=10090 GN=Wdr55 PE=1 SV=2)

HSP 1 Score: 135.576 bits (340), Expect = 2.080e-34
Identity = 84/289 (29.07%), Postives = 143/289 (49.48%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWHKNLSRLAV-SKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            ++ + P+ I L+  A G+A   FHP +D+L  G V+G V +  Y C +   +EL+    H    R  V S+ G +++T S    I   D E G+       AH   I++++       ++ DD+  ++ WD R++ P+ +M                  +  Y++    + LD   + L  A  DG L   N K+R+ EL SE  +    S+   K   K+   + EG I +FNWN FG  SDRF +  +++ I+ ++ + EN++  G+  G I+AV++LPN V+  +G
Sbjct:   28 RIRDTPEDIVLEAPASGLA---FHPTRDLLAAGDVDGDVFVFAYSCQEGETKELWSSGHHLKSCRAVVFSEDGQKLVTVSKDKAIHILDVEQGQLERRISKAHSAPINSVLLVDENALVTGDDTGGIRLWDQRKEGPLMDMR----------------QHEEYIAD---MALDPAKKLLLTASGDGCLGVFNIKRRRFELLSEPQSGDLTSVALMKYGKKVACGSSEGTIYLFNWNGFGATSDRFAL--RAESIDCIVPVTENLLCTGSTDGIIRAVNILPNRVVGTVG 292

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BLAST of WD repeat-containing protein 55 vs. UniProt/SwissProt
Match: sp|Q9H6Y2|WDR55_HUMAN (WD repeat-containing protein 55 OS=Homo sapiens OX=9606 GN=WDR55 PE=1 SV=2)

HSP 1 Score: 132.494 bits (332), Expect = 2.334e-33
Identity = 84/289 (29.07%), Postives = 142/289 (49.13%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWHKNLSR-LAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            ++ + P+ I L+  A G+A   FHP +D+L  G V+G V +  Y C +   +EL+    H    R +A S+ G +++T S    I   D E G+       AH   I++++        + DD+  +  WD R++ P+ +M                  +  Y++    + LD   + L  A  DG L   N K+R+ EL SE  +    S+   K   K+   + EG I +FNWN FG  SDRF +  +++ I+ M+ + E+++  G+  G I+AV++LPN V+  +G
Sbjct:   27 RIRDTPEDIVLEAPASGLA---FHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQGQLERRVSKAHGAPINSLLLVDENVLATGDDTGGICLWDQRKEGPLMDMR----------------QHEEYIAD---MALDPAKKLLLTASGDGCLGIFNIKRRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEGTIYLFNWNGFGATSDRFAL--RAESIDCMVPVTESLLCTGSTDGVIRAVNILPNRVVGSVG 291

[Close]

BLAST of WD repeat-containing protein 55 vs. TrEMBL
Match: A0A4Z2CYC1 (WD repeat-containing protein OS=Schistosoma japonicum OX=6182 GN=EWB00_006637 PE=4 SV=1)

HSP 1 Score: 221.861 bits (564), Expect = 3.269e-64
Identity = 137/395 (34.68%), Postives = 216/395 (54.68%), Query Frame = 1

Query:   25 IPQHIKLQIGADGIAELKFHPKKD--ILVIGTVEGRVRIYDCNKSSPEELFRKKWHKNLSRLAVSKTGCEILTS-SNQGCIKEHDFEYGKETWSNLNAHQEG-ISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRH--LFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPV--VKKSQQ------------IETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCG-DCMTLDTNFTHNIVASGCPESNIVCFFSTE---KATEEFSILLQDRSENKRKNSGNLKEVRKRR----KIEEDDGFLDGL 1125
            +   + L+IG DGI+   F    D  +  +GT  GR+RIYD    + E L +K+WHK +  L+       +LTS S Q  +K HD    K+TWS L AH++  IS+I+      W++ D+  I+K WD+R+  PV  M I   ++  DD            +S+N + +  N  H  L AA+DDGTL   N ++R+ E+ SETL FSA+++   KN +K+ + +DEGV+S+FNWN+FGN+ DRFP+  ++ S+Q            +E ++K+ E++V V T+ G I A+++LPN +L  +G       N+  G DC++L  + T NI+AS  P +  + F+ T    K  E  S+ L+     ++  S   K V+ RR     + E   +L+GL
Sbjct:    3 LSDQLDLKIGLDGISCTDFATVSDKILFAVGTCNGRIRIYDYMNRT-EALLQKRWHKTIRCLSFFPKDQNLLTSASRQSGLKVHDIIAEKQTWSCLKAHEKSPISSILVLEHGQWVTGDEDGIIKMWDARKSGPVAVM-IPDVDNRFDD----------LFNSINEMTVSSNDSHGTLLAAVDDGTLAVYNIRRRRFEMSSETLGFSARTLTIVKNNTKVLVGSDEGVVSVFNWNEFGNICDRFPIHPLRPSKQGQARTAVSGVNSVEKIVKITEDIVAVATDDGVISAINILPNRLLGCVGCHTDAANNDASGADCLSLSVHPTENIIASTYPANRSIKFWDTSRFIKHAENESMELRLPKHQRKLPSAKFKGVKSRRLCLTDVNERMEYLNGL 385

[Close]

BLAST of WD repeat-containing protein 55 vs. TrEMBL
Match: A0A095AMU0 (WD repeat-containing protein 55 OS=Schistosoma haematobium OX=6185 GN=MS3_03765 PE=4 SV=1)

HSP 1 Score: 217.624 bits (553), Expect = 1.372e-62
Identity = 139/398 (34.92%), Postives = 222/398 (55.78%), Query Frame = 1

Query:   16 MSEIPQHIKLQIGADGIAELKFHPKKD--ILVIGTVEGRVRIYDCNKSSPEELFRKKWHKNLSRLAV-SKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEG-ISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRH--LFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPV--VKKSQQ------------IETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCG-DCMTLDTNFTHNIVASGCPESNIVCFFSTEKATE--EFSILLQDRSENKRK-NSGNLKEVRKRRKIEEDDG----FLDGL 1125
            M +    + L+IG DGI+   F    D  +L +GT  GR+RI+D    + + L +K+WHK +  L+   KT   ++++S+Q  +K HD    K+TW+   AH++  IS+++      W++ D++ I+K WD+R+  PV  M     N + DD          + +S+N + +  N  H  L AA+DDGTL   N ++R+ E+ SETL FSA+++   KN +K+ + TDEGVIS+F+WN+FGN+ DRFP+  ++ S+Q            +E ++K+ E++V V T+ G + A+ +LPN +L  +G       N+  G DCMTL  + T NI+AS  P S+ + F++T K  E  E         +N+RK  S  LK V+ RR    D      +L+GL
Sbjct:    1 MMDPSNQLDLKIGLDGISCTDFATVGDKILLAVGTCNGRIRIFDYVDRT-KALLQKRWHKTIRCLSFFPKTQNLLISASSQSGLKVHDVISEKQTWACFQAHEKSQISSVLVLEHGQWVTGDENGIIKMWDARKSGPVSVMTPDLEN-KFDD----------FFNSINEMAVSSNDSHGTLLAAVDDGTLAVYNIRRRRFEMSSETLGFSARTLTVVKNNTKVLVGTDEGVISVFSWNEFGNICDRFPIHPLRPSKQGQARTAVSGGNSVEKIVKITEDIVAVATDDGVVSAMHILPNRLLGCVGYHIDTANNDTSGADCMTLSIHPTENIIASTFPASSSIKFWNTSKFIEHAENETAELRLPKNQRKLPSTKLKGVKSRRLCLTDANERMEYLEGL 386

[Close]

BLAST of WD repeat-containing protein 55 vs. TrEMBL
Match: A0A5K4FG21 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 217.238 bits (552), Expect = 1.858e-62
Identity = 138/393 (35.11%), Postives = 220/393 (55.98%), Query Frame = 1

Query:   34 HIKLQIGADGIAELKFHPKKD--ILVIGTVEGRVRIYDCNKSSPEELFRKKWHKNLSRLAV-SKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEG-ISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRH--LFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPV--VKKSQQ------------IETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCG-DCMTLDTNFTHNIVASGCPESNIVCFFSTEKATE----EFSILLQDRSENKRKNSGNLKEVRKRRKIEEDDG----FLDGL 1125
             + L+IG DGI+   F    D  +L +GT  GR+RIYD    + + L +K+WHK +  L+   KT   ++++S+Q  +K HD    K+TW+   AH++  IS+I+      W++ D++ I+K WD+R+   V  M     N + DD          + +S+N + +  N  H  L AA+DDGTL   N ++R+ E+ SETL FSA+++   KN SK+ + TDEGVIS+F+WN+FGN+ DRFP+  ++ S+Q            +E ++K+ E++V V T+ G + A+ ++PN +L  +G       N+  G DC+TL  + T NI+AS CP S+ + F++T K  E    E + L   +S+ K   S  LK  + RR    D      +L+GL
Sbjct:    6 QLDLKIGLDGISCTDFANVGDKILLAVGTCNGRIRIYDYMDRT-KALLQKRWHKTIRCLSFFPKTQNLLISASSQSGLKVHDVISEKQTWACFQAHEKSPISSILVLEHGQWVTGDENGIIKMWDARKSGSVSVMTPDIEN-KFDD----------FFNSINEMAISSNDSHGTLLAAVDDGTLAVYNIRRRRFEMSSETLGFSARTLTVVKNNSKVLVGTDEGVISVFSWNEFGNICDRFPIHPLRPSKQGQARTAVSGGISVEKIVKITEDIVAVATDDGVVSAMHIIPNRLLGCVGYHIDAANNDTSGADCITLSVHPTENIIASTCPTSSSIKFWNTSKFVEHAENETAELRLPKSQRKLP-STKLKGAKSRRLCLTDTNERMEYLEGL 385

[Close]

BLAST of WD repeat-containing protein 55 vs. TrEMBL
Match: A0A068WR11 (WD repeat containing protein 55 OS=Echinococcus granulosus OX=6210 GN=EgrG_000344200 PE=4 SV=1)

HSP 1 Score: 207.223 bits (526), Expect = 1.622e-58
Identity = 131/400 (32.75%), Postives = 212/400 (53.00%), Query Frame = 1

Query:   28 PQHIKLQIGADGIAELKFHPK--KDILVIGTVEGRVRIYDCNKSSPEELFRKKWHKNLSRLAV---SKTGCEILTSSNQGCIKEHDFEYGKET-WSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLD-DNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQ-----------------IETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCGDCMTLDTNFTHNIV---ASGCPESNIVCFFS-----TEKATEEFSILLQDRSENKRKNSGNLKEVRKRRKIEEDDGFLDGLCQ 1131
            P +++L IG DG++ L F P   K++L++GT  GRVRI DC++++ + L++K+WHK++  L V   S T C  +T+SNQGC+K HD E  K   +   +      SA++  T   W++ DD+ ++K WD R ++  C   I    +E D +          L   N L +  D    L AA++ G LVT + ++R++E  SE L +SA+S+ + KN SK+ + TDEGVI ++NW +FG++ DRFPV     +                 +E ++K+ EN+V++ T+ GAI  +S+LPN +L+ +G         G GDCMTL  +    +V   ASG P +  + F+S      E   E   ++  ++   +R        V  R    + + FL GL +
Sbjct:   11 PSNMQLFIGIDGVSSLCFVPSIDKNLLMVGTTGGRVRILDCSRNTCKTLYQKRWHKSIRCLVVNPFSPTSC--ITASNQGCLKVHDIETKKRIGYFTGSGDSSPFSALVAVTNHRWVTGDDNGMIKIWDDRLKEGHC-FTIKPNTNEMDAD----------LCGTNDLAVGADPQGTLLAAVESGCLVTYSIRRRRLETISEPLGYSARSVCSIKNGSKVLLGTDEGVILMYNWGEFGSICDRFPVRTSRTRVDHRSGTKLFDEAGCPAVEKIVKVTENIVVIATDDGAISPMSILPNRMLTCLGWHTADEATGGGGDCMTLAVSPASTVVPLLASGLPLAPSLKFWSVEHLPAEAEAESAKVVTGEKMMTQRYGRDAKARVTSRGADRDREDFLSGLTE 397

[Close]

BLAST of WD repeat-containing protein 55 vs. TrEMBL
Match: W6U1Z2 (WD repeat-containing protein OS=Echinococcus granulosus OX=6210 GN=EGR_10008 PE=4 SV=1)

HSP 1 Score: 207.223 bits (526), Expect = 4.142e-58
Identity = 131/400 (32.75%), Postives = 212/400 (53.00%), Query Frame = 1

Query:   28 PQHIKLQIGADGIAELKFHPK--KDILVIGTVEGRVRIYDCNKSSPEELFRKKWHKNLSRLAV---SKTGCEILTSSNQGCIKEHDFEYGKET-WSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLD-DNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQ-----------------IETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCGDCMTLDTNFTHNIV---ASGCPESNIVCFFS-----TEKATEEFSILLQDRSENKRKNSGNLKEVRKRRKIEEDDGFLDGLCQ 1131
            P +++L IG DG++ L F P   K++L++GT  GRVRI DC++++ + L++K+WHK++  L V   S T C  +T+SNQGC+K HD E  K   +   +      SA++  T   W++ DD+ ++K WD R ++  C   I    +E D +          L   N L +  D    L AA++ G LVT + ++R++E  SE L +SA+S+ + KN SK+ + TDEGVI ++NW +FG++ DRFPV     +                 +E ++K+ EN+V++ T+ GAI  +S+LPN +L+ +G         G GDCMTL  +    +V   ASG P +  + F+S      E   E   ++  ++   +R        V  R    + + FL GL +
Sbjct:   27 PSNMQLFIGIDGVSSLCFVPSIDKNLLMVGTTGGRVRILDCSRNTCKTLYQKRWHKSIRCLVVNPFSPTSC--ITASNQGCLKVHDIETKKRIGYFTGSGDSSPFSALVAVTNHRWVTGDDNGMIKIWDDRLKEGHC-FTIKPNTNEMDAD----------LCGTNDLAVGADPQGTLLAAVESGCLVTYSIRRRRLETISEPLGYSARSVCSIKNGSKVLLGTDEGVILMYNWGEFGSICDRFPVRTSRTRVDHRSGTKLFDEAGCPAVEKIVKVTENIVVIATDDGAISPMSILPNRMLTCLGWHTADEATGGGGDCMTLAVSPASTVVPLLASGLPLAPSLKFWSVEHLPAEAEAESAKVVTGEKMMTQRYGRDAKARVTSRGADRDREDFLSGLTE 413

[Close]

BLAST of WD repeat-containing protein 55 vs. Ensembl Cavefish
Match: wdr55 (WD repeat domain 55 [Source:NCBI gene;Acc:107197361])

HSP 1 Score: 121.709 bits (304), Expect = 3.180e-30
Identity = 78/289 (26.99%), Postives = 142/289 (49.13%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRIY--DCNKSSPEELFRKKWH-KNLSRLAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            K+ E P+ IK +   + +A   FHPK+D+L  G ++G + +Y   C     +EL+    H K+  ++A S  G ++ + S    +   D E GK       AH + I+A++      + + DD   L  WD R+                   ++ MS   H+   ++ + +D   + L  +  DG++   N K+R+ EL SE       S+   K   K+   + EG I IFNWN+FG++SDRF +  +++ ++ ++ + ++++   +  G I+AV++LPN  +  IG
Sbjct:   37 KIQETPEDIKQEAIVNTLA---FHPKEDLLAAGDIDGDIYLYRYSCTVGENKELWSSGHHLKSCRKVAFSSDGEKLFSVSKDKAVHIMDVEAGKLATRIPKAHSKPINALLIVDENIFATGDDEGTLNVWDLRKG------------------TSFMSLK-HHEDFISGIAVDQAKKILLTSSGDGSMGVFNIKRRRFELLSEIQDGDLTSVSIMKRGQKVVCGSSEGTIYIFNWNEFGDMSDRFDL--QAESVDCIVPITDSILCAASTDGVIRAVNILPNRAVGRIG 301

[Close]

BLAST of WD repeat-containing protein 55 vs. Ensembl Sea Lamprey
Match: wdr55 (WD repeat domain 55 [Source:NCBI gene;Acc:445394])

HSP 1 Score: 121.709 bits (304), Expect = 6.581e-31
Identity = 78/289 (26.99%), Postives = 136/289 (47.06%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRIYD--CNKSSPEELFRKKWHKNLSR-LAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            ++ E P+ IKL+  A     +  HP +D++ +G ++G + +Y   C +    EL+    H+   R LA S  G ++ + S    +   D E GK       AH   I ++         +  D  +++ WD RQ   V E                + H       V+++V+ D+ R L     DGTL   N ++R+ +++SE       S+   K  +K+   + EG + +FNW  FG +SDRF    +++ ++ + ++ +N+V   +  G I+AVSLLPN VL  +G
Sbjct:   44 RVREAPEDIKLEAIA---TTMCMHPSRDVMAVGDLDGDIFLYSYSCTEGETRELWSSGHHRKACRGLAFSDDGAQLYSVSKDKSVLLFDVEQGKLVKRIQKAHDSAIYSLAVIDENLTATGGDDGVVRVWDFRQGTYVMEQ---------------LEHTDF----VSSMVVGDDKRTLLTTSGDGTLCAFNVRRRRFDVKSEVQDCDLTSLAIVKEGTKVVCGSSEGWLLLFNWGGFGAVSDRFST--RTESVDCLARVSDNLVCTASMDGIIRAVSLLPNRVLGVVG 308

[Close]

BLAST of WD repeat-containing protein 55 vs. Ensembl Nematostella
Match: EDO47048 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNE8])

HSP 1 Score: 110.538 bits (275), Expect = 3.760e-27
Identity = 82/292 (28.08%), Postives = 135/292 (46.23%), Query Frame = 1

Query:   25 IPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRI--YDCNKSSPEELFRKKWHKNLSR-LAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQ-EFPV 888
            IP  I L   +  + ++ FHP++D++ +  + G V +  Y+  K S + L     HK   R LA SK G  + T+S    ++  D   G    +   AH   ++ +   +     + DD   +K WDSR    V EM                  N  ++S +     D + + L A   DG+L   N ++ K E  S+ +     S+   K   K+   T EG ++IF+W ++G+LSDRFP     Q ++  + +  NVV  G+  G I+AV +LPN +L  +G   +FP+
Sbjct:   17 IPGPITL---SSQVFDVGFHPERDVIAVAQIAGTVSLHSYEAGKDS-KMLMELNHHKKPCRALAFSKDGLHLFTASKDKSLQAIDMNSGSIAHAIKKAHSCPVNCLKVISDHLVATGDDEGSVKVWDSRTVACVMEMK----------------ENEDFISDMEC---DSDCKLLLATSGDGSLSVFNVRRHKHEDSSDNVETELLSLAIVKGGRKVVCGTGEGTLNIFSWGEWGDLSDRFP--GHPQSVDACVAIGNNVVCTGSIDGIIRAVHILPNRLLGPVGEHADFPI 283

[Close]

BLAST of WD repeat-containing protein 55 vs. Ensembl Medaka
Match: wdr55 (WD repeat domain 55 [Source:NCBI gene;Acc:100192344])

HSP 1 Score: 128.257 bits (321), Expect = 1.368e-32
Identity = 82/289 (28.37%), Postives = 139/289 (48.10%), Query Frame = 1

Query:   13 KMSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRIY--DCNKSSPEELFRKKWH-KNLSRLAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIG 870
            K+ E P+ I+L+  A+ +A    HP +D+LV G V+G V  Y   C +    EL+    H K+  ++  S  G ++ + S    + + D E G+       AH   I++++        + DD   LK WD R+ +   ++                 H+  Y+S +    +D   R L     DGT+   N K+R+ EL SE  +    S+   K   K+   + EG + IFNWN FG  SDRF V  K++ ++ ++ + ++++   +  G I+A++LLPN V+  IG
Sbjct:   43 KIRETPEDIRLEAIANTVA---LHPSRDVLVCGDVDGDVYAYAYSCTEGETRELWSSGHHLKSCRQVRFSADGLKLFSVSRDKAVHQLDVERGQLVSRIRGAHAAAINSLLLVDENILATGDDRGTLKVWDMRKGEAFMDLK----------------HHDDYISDI---AVDQAKRILLTTSGDGTMGVFNIKRRRFELLSEFQSGDLTSVALMKRGKKVVCGSSEGTVYIFNWNGFGATSDRFAV--KAESVDCIVPITDSIMCTASMDGYIRAINLLPNRVIGCIG 307

[Close]

BLAST of WD repeat-containing protein 55 vs. Planmine SMEST
Match: SMESG000072415.1 (SMESG000072415.1)

HSP 1 Score: 774.237 bits (1998), Expect = 0.000e+0
Identity = 411/415 (99.04%), Postives = 413/415 (99.52%), Query Frame = 1

Query:   16 MSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRIYDCNKSSPEELFRKKWHKNLSRLAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCGDCMTLDTNFTHNIVASGCPESNIVCFFSTEKATEEFSILLQDRSENKRKNSGNLKEVRKRRKIEEDDGFLDGLCQVSKIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTGVESDN 1260
            MSEIPQHIKLQIGADGIAELKFHP K+ILVIGTVEGRVRIYDCNKSSPEELFRKKWHKNLSRLAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDES LMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCGDCMTLDTNFTHNIVASGCPESNIVCFFSTEKATEEFSILLQDRSENKRKNSGNLKEVRKRRKIEEDDGFLDGLCQVSKIDE+SDDDEDRDSDDDENEDSNDSEEIDSIEESTGVESDN
Sbjct:    1 MSEIPQHIKLQIGADGIAELKFHPNKNILVIGTVEGRVRIYDCNKSSPEELFRKKWHKNLSRLAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQEGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDESVLMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSETLAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQIETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCGDCMTLDTNFTHNIVASGCPESNIVCFFSTEKATEEFSILLQDRSENKRKNSGNLKEVRKRRKIEEDDGFLDGLCQVSKIDENSDDDEDRDSDDDENEDSNDSEEIDSIEESTGVESDN 415

The following BLAST results are available for this feature:

BLAST of WD repeat-containing protein 55 vs. Ensembl Human
BLAST of WD repeat-containing protein 55 vs. Ensembl Celegans
BLAST of WD repeat-containing protein 55 vs. Ensembl Fly
BLAST of WD repeat-containing protein 55 vs. Ensembl Zebrafish
BLAST of WD repeat-containing protein 55 vs. Ensembl Xenopus
BLAST of WD repeat-containing protein 55 vs. Ensembl Mouse
BLAST of WD repeat-containing protein 55 vs. UniProt/SwissProt
BLAST of WD repeat-containing protein 55 vs. TrEMBL
BLAST of WD repeat-containing protein 55 vs. Ensembl Cavefish
BLAST of WD repeat-containing protein 55 vs. Ensembl Sea Lamprey
BLAST of WD repeat-containing protein 55 vs. Ensembl Yeast
BLAST of WD repeat-containing protein 55 vs. Ensembl Nematostella
BLAST of WD repeat-containing protein 55 vs. Ensembl Medaka
BLAST of WD repeat-containing protein 55 vs. Planmine SMEST

BLAST of WD repeat-containing protein 55 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2


Match Name	E-value	Identity	Description
WDR55	4.859e-34	29.07	WD repeat domain 55 [Source:HGNC Symbol;Acc:HGNC:2...	[more]
WDR55	2.624e-18	33.83	WD repeat domain 55 [Source:HGNC Symbol;Acc:HGNC:2...	[more]

BLAST of WD repeat-containing protein 55 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Y44F5A.1	2.130e-7	28.70	3E324 [Source:UniProtKB/TrEMBL;Acc:G5EEZ4]	[more]

BLAST of WD repeat-containing protein 55 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
CG14722	4.196e-26	25.66	gene:FBgn0037943 transcript:FBtr0082431	[more]

BLAST of WD repeat-containing protein 55 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
wdr55	1.757e-34	28.02	WD repeat domain 55 [Source:NCBI gene;Acc:445394]	[more]
wdr55	3.429e-34	29.76	WD repeat domain 55 [Source:NCBI gene;Acc:445394]	[more]

BLAST of WD repeat-containing protein 55 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1


Match Name	E-value	Identity	Description
selp	3.733e-34	30.10	selectin P [Source:Xenbase;Acc:XB-GENE-482807]	[more]

BLAST of WD repeat-containing protein 55 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Wdr55	2.974e-35	29.07	WD repeat domain 55 [Source:MGI Symbol;Acc:MGI:191...	[more]

BLAST of WD repeat-containing protein 55 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|A1L112\|WDR55_RAT	4.358e-35	29.41	WD repeat-containing protein 55 OS=Rattus norvegic...	[more]
sp\|Q58DT8\|WDR55_BOVIN	7.720e-35	28.34	WD repeat-containing protein 55 OS=Bos taurus OX=9...	[more]
sp\|Q5R9T6\|WDR55_PONAB	1.402e-34	28.34	WD repeat-containing protein 55 OS=Pongo abelii OX...	[more]
sp\|Q9CX97\|WDR55_MOUSE	2.080e-34	29.07	WD repeat-containing protein 55 OS=Mus musculus OX...	[more]
sp\|Q9H6Y2\|WDR55_HUMAN	2.334e-33	29.07	WD repeat-containing protein 55 OS=Homo sapiens OX...	[more]

BLAST of WD repeat-containing protein 55 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4Z2CYC1	3.269e-64	34.68	WD repeat-containing protein OS=Schistosoma japoni...	[more]
A0A095AMU0	1.372e-62	34.92	WD repeat-containing protein 55 OS=Schistosoma hae...	[more]
A0A5K4FG21	1.858e-62	35.11	Uncharacterized protein OS=Schistosoma mansoni OX=...	[more]
A0A068WR11	1.622e-58	32.75	WD repeat containing protein 55 OS=Echinococcus gr...	[more]
W6U1Z2	4.142e-58	32.75	WD repeat-containing protein OS=Echinococcus granu...	[more]

BLAST of WD repeat-containing protein 55 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
wdr55	3.180e-30	26.99	WD repeat domain 55 [Source:NCBI gene;Acc:10719736...	[more]

BLAST of WD repeat-containing protein 55 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
wdr55	6.581e-31	26.99	WD repeat domain 55 [Source:NCBI gene;Acc:445394]	[more]

BLAST of WD repeat-containing protein 55 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of WD repeat-containing protein 55 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO47048	3.760e-27	28.08	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of WD repeat-containing protein 55 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
wdr55	1.368e-32	28.37	WD repeat domain 55 [Source:NCBI gene;Acc:10019234...	[more]

BLAST of WD repeat-containing protein 55 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000072415.1	0.000e+0	99.04	SMESG000072415.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30030189 ID=SMED30030189|Name=WD repeat-containing protein 55|organism=Schmidtea mediterranea sexual|type=transcript|length=1306bp
GAAAGTTTTTGAAAAATGAGTGAAATCCCACAACACATAAAATTGCAAAT
AGGTGCTGATGGAATTGCTGAATTAAAATTCCATCCCAAAAAAGATATTC
TTGTTATAGGAACAGTCGAAGGACGCGTTAGAATTTACGATTGCAATAAA
AGTAGTCCAGAAGAACTTTTCCGTAAAAAATGGCACAAAAACCTTAGTAG
ATTGGCTGTATCTAAAACTGGTTGCGAAATTCTTACAAGTTCTAATCAAG
GTTGTATCAAAGAGCATGATTTCGAATACGGAAAAGAAACATGGAGCAAT
CTAAATGCTCACCAAGAAGGTATTTCGGCAATTATATACCAAACAGCTAA
AACTTGGATATCTGCTGATGATAGCAGTATTTTGAAATTTTGGGACTCAA
GGCAACAAGATCCAGTTTGCGAAATGAATATTTGCGCCCCAAATGATGAA
TGTGATGATGAAAGTGCCCTAATGTCTCACAATAGCCATTATTTAAGCTC
AGTCAATGCTTTGGTTTTGGATGATAATGGACGACATTTATTTGCTGCAA
TGGACGATGGAACATTGGTGACTATTAATCCTAAAAAAAGAAAAGTAGAA
TTACGCTCTGAAACATTAGCCTTTAGTGCAAAATCAATTGTAACTTTTAA
AAATCAATCGAAACTGGGAATAGCTACAGATGAAGGTGTAATTAGTATTT
TCAACTGGAATCAGTTTGGAAACCTTTCTGACAGATTTCCTGTTGTTAAA
AAAAGTCAGCAAATCGAAACAATGATCAAACTGGACGAGAACGTAGTTCT
CGTGGGGACTAATAAAGGAGCTATCAAAGCTGTATCATTGTTGCCCAACT
GTGTTCTTTCTGATATTGGTTTGCAAGAATTTCCAGTTGGTAATGAAGGA
TGTGGAGATTGTATGACATTGGATACCAATTTTACACATAATATCGTCGC
TTCCGGTTGTCCAGAAAGCAATATCGTCTGTTTCTTTTCCACGGAAAAAG
CCACTGAAGAATTTTCAATTTTATTGCAAGATCGATCGGAAAATAAAAGA
AAAAACAGTGGAAATTTGAAAGAAGTTCGAAAGAGAAGGAAAATTGAAGA
AGATGACGGTTTTCTTGATGGTCTTTGTCAAGTTTCTAAAATCGATGAAG
ATTCTGACGATGATGAAGACCGAGATTCTGATGATGACGAAAATGAAGAT
TCTAACGATTCTGAAGAAATTGATTCAATTGAAGAATCTACTGGTGTAGA
ATCCGACAATTGAAAAACATTTTTATGCTGATGTAAATATATTTTCATAA
AAAAAA

protein sequence of SMED30030189-orf-1

>SMED30030189-orf-1 ID=SMED30030189-orf-1|Name=SMED30030189-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=416bp
MSEIPQHIKLQIGADGIAELKFHPKKDILVIGTVEGRVRIYDCNKSSPEE
LFRKKWHKNLSRLAVSKTGCEILTSSNQGCIKEHDFEYGKETWSNLNAHQ
EGISAIIYQTAKTWISADDSSILKFWDSRQQDPVCEMNICAPNDECDDES
ALMSHNSHYLSSVNALVLDDNGRHLFAAMDDGTLVTINPKKRKVELRSET
LAFSAKSIVTFKNQSKLGIATDEGVISIFNWNQFGNLSDRFPVVKKSQQI
ETMIKLDENVVLVGTNKGAIKAVSLLPNCVLSDIGLQEFPVGNEGCGDCM
TLDTNFTHNIVASGCPESNIVCFFSTEKATEEFSILLQDRSENKRKNSGN
LKEVRKRRKIEEDDGFLDGLCQVSKIDEDSDDDEDRDSDDDENEDSNDSE
EIDSIEESTGVESDN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036322	WD40_repeat_dom_sf
IPR001680	WD40_repeat
IPR015943	WD40/YVTN_repeat-like_dom_sf
IPR017986	WD40_repeat_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Vocabulary: **biological process**
Term	Definition
GO:0006364	rRNA processing
GO:0042273	ribosomal large subunit biogenesis

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001680	WD40 repeat	SMART	SM00320	WD40_4	coord: 89..127 e-value: 14.0 score: 9.8 coord: 3..42 e-value: 3.0 score: 14.0 coord: 47..85 e-value: 22.0 score: 8.5 coord: 148..188 e-value: 14.0 score: 9.9
IPR015943	WD40/YVTN repeat-like-containing domain superfamily	GENE3D	G3DSA:2.130.10.10		coord: 11..278 e-value: 8.8E-22 score: 79.5
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 371..415
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 378..415
None	No IPR available	PANTHER	PTHR44156	FAMILY NOT NAMED	coord: 158..399
None	No IPR available	PANTHER	PTHR44156	FAMILY NOT NAMED	coord: 17..138
None	No IPR available	PANTHER	PTHR44156:SF5	WD REPEAT-CONTAINING PROTEIN 55	coord: 158..399 coord: 17..138
IPR017986	WD40-repeat-containing domain	PROSITE	PS50294	WD_REPEATS_REGION	coord: 10..136 score: 10.417
IPR036322	WD40-repeat-containing domain superfamily	SUPERFAMILY	SSF50978	WD40 repeat-like	coord: 12..324

Main menu

WD repeat-containing protein 55

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Owlery

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