Replication stress response regulator SDE2

Overview
NameReplication stress response regulator SDE2
Smed IDSMED30030187
Length (bp)1207
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Replication stress response regulator SDE2 (SMED30030187) t-SNE clustered cells

Violin plots show distribution of expression levels for Replication stress response regulator SDE2 (SMED30030187) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Replication stress response regulator SDE2 (SMED30030187) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Replication stress response regulator SDE2 (SMED30030187) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30030187

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30030187SMESG000046900.1 SmedASXL_012710SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
posterior sideSMED30030187SMESG000046900.1 dd_Smed_v4_5448_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30030187SMESG000046900.1 dd_Smed_v4_5448_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Human
Match: SDE2 (SDE2 telomere maintenance homolog [Source:HGNC Symbol;Acc:HGNC:26643])

HSP 1 Score: 98.5969 bits (244), Expect = 7.107e-22
Identity = 43/77 (55.84%), Postives = 56/77 (72.73%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            NF+   NG +++    V    +     RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +W+
Sbjct:   46 NFFVKCNGALINTSDTVQHGAVYSLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWV 122
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Fly
Match: CG5986 (gene:FBgn0043455 transcript:FBtr0084535)

HSP 1 Score: 92.0485 bits (227), Expect = 3.084e-21
Identity = 41/59 (69.49%), Postives = 49/59 (83.05%), Query Frame = 3 
Query:  141 NGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLD 317
            +G V    R  GGKGGFGSMLRAIG+QIEKTTNRE CRDL+GRR+RD+N EKR++ WL+
Sbjct:   54 SGDVHCVLRQLGGKGGFGSMLRAIGAQIEKTTNREACRDLSGRRLRDINEEKRVRAWLE 112
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Fly
Match: CG5986 (gene:FBgn0043455 transcript:FBtr0321261)

HSP 1 Score: 92.0485 bits (227), Expect = 3.084e-21
Identity = 41/59 (69.49%), Postives = 49/59 (83.05%), Query Frame = 3 
Query:  141 NGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLD 317
            +G V    R  GGKGGFGSMLRAIG+QIEKTTNRE CRDL+GRR+RD+N EKR++ WL+
Sbjct:   54 SGDVHCVLRQLGGKGGFGSMLRAIGAQIEKTTNREACRDLSGRRLRDINEEKRVRAWLE 112
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Zebrafish
Match: sde2 (SDE2 telomere maintenance homolog (S. pombe) [Source:NCBI gene;Acc:550448])

HSP 1 Score: 98.5969 bits (244), Expect = 4.642e-22
Identity = 47/81 (58.02%), Postives = 63/81 (77.78%), Query Frame = 3 
Query:   81 SNFYYTFNGFIV--HDLAEVPINGIVQK-HYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            ++FY + NG +   +DL +   +G+V +   RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +WL
Sbjct:   39 TDFYVSSNGRLSRSNDLLQ---SGVVYRLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKEMAEWL 116

HSP 2 Score: 58.5362 bits (140), Expect = 5.912e-9
Identity = 41/113 (36.28%), Postives = 58/113 (51.33%), Query Frame = 3 
Query:  753 LEKYAVETSKTNGDISK-SEESVKEVLFAD----------------INLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT--EYPASLLVGAVRTKRR 1034
            +EK A E  KT  ++ K +EES  E+  +                 ++L SV     L   G + +K +LM RG+K GGTL ERA RL+SVKGLT  +   SLL    + K++
Sbjct:  355 VEKMAEEVQKTAEEVQKKTEESTAEISPSSSIPEEKSQVLSQVEDPLDLLSVSGPEQLEALGLERLKKELMERGMKCGGTLQERAARLFSVKGLTPDQIDPSLLAKPSKGKKK 467
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Zebrafish
Match: sde2 (SDE2 telomere maintenance homolog (S. pombe) [Source:NCBI gene;Acc:550448])

HSP 1 Score: 98.2117 bits (243), Expect = 7.061e-22
Identity = 47/81 (58.02%), Postives = 63/81 (77.78%), Query Frame = 3 
Query:   81 SNFYYTFNGFIV--HDLAEVPINGIVQK-HYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            ++FY + NG +   +DL +   +G+V +   RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +WL
Sbjct:   59 TDFYVSSNGRLSRSNDLLQ---SGVVYRLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKEMAEWL 136

HSP 2 Score: 58.5362 bits (140), Expect = 6.108e-9
Identity = 41/113 (36.28%), Postives = 58/113 (51.33%), Query Frame = 3 
Query:  753 LEKYAVETSKTNGDISK-SEESVKEVLFAD----------------INLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT--EYPASLLVGAVRTKRR 1034
            +EK A E  KT  ++ K +EES  E+  +                 ++L SV     L   G + +K +LM RG+K GGTL ERA RL+SVKGLT  +   SLL    + K++
Sbjct:  375 VEKMAEEVQKTAEEVQKKTEESTAEISPSSSIPEEKSQVLSQVEDPLDLLSVSGPEQLEALGLERLKKELMERGMKCGGTLQERAARLFSVKGLTPDQIDPSLLAKPSKGKKK 487
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Zebrafish
Match: sf3a3 (splicing factor 3a, subunit 3 [Source:ZFIN;Acc:ZDB-GENE-040908-1])

HSP 1 Score: 49.2914 bits (116), Expect = 5.287e-6
Identity = 25/49 (51.02%), Postives = 32/49 (65.31%), Query Frame = 3 
Query:  834 ADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKG 980
            A ++L +  S   L + G D +K+ LM  GLK GGTL ERAQRL+S KG
Sbjct:  160 AHLDLSAFSSWEELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKG 208
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Zebrafish
Match: sf3a3 (splicing factor 3a, subunit 3 [Source:ZFIN;Acc:ZDB-GENE-040908-1])

HSP 1 Score: 49.2914 bits (116), Expect = 5.405e-6
Identity = 25/49 (51.02%), Postives = 32/49 (65.31%), Query Frame = 3 
Query:  834 ADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKG 980
            A ++L +  S   L + G D +K+ LM  GLK GGTL ERAQRL+S KG
Sbjct:  242 AHLDLSAFSSWEELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKG 290
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Zebrafish
Match: sf3a3 (splicing factor 3a, subunit 3 [Source:ZFIN;Acc:ZDB-GENE-040908-1])

HSP 1 Score: 49.2914 bits (116), Expect = 5.405e-6
Identity = 25/49 (51.02%), Postives = 32/49 (65.31%), Query Frame = 3 
Query:  834 ADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKG 980
            A ++L +  S   L + G D +K+ LM  GLK GGTL ERAQRL+S KG
Sbjct:  242 AHLDLSAFSSWEELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKG 290
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Xenopus
Match: sde2 (SDE2 telomere maintenance homolog (S. pombe) [Source:NCBI gene;Acc:100145674])

HSP 1 Score: 97.4413 bits (241), Expect = 1.446e-21
Identity = 49/86 (56.98%), Postives = 63/86 (73.26%), Query Frame = 3 
Query:   69 SIMDSNFYYTFNGFIVHDLAEVPINGIVQKHY----RLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            +I  ++FY T NG +  DL E   +G   + Y    RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +W+
Sbjct:   35 AIPLTDFYITCNGHLA-DLEEKLQDG---RTYSIVPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWI 116
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Xenopus
Match: sde2 (SDE2 telomere maintenance homolog (S. pombe) [Source:NCBI gene;Acc:100145674])

HSP 1 Score: 97.4413 bits (241), Expect = 1.451e-21
Identity = 49/86 (56.98%), Postives = 63/86 (73.26%), Query Frame = 3 
Query:   69 SIMDSNFYYTFNGFIVHDLAEVPINGIVQKHY----RLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            +I  ++FY T NG +  DL E   +G   + Y    RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +W+
Sbjct:   35 AIPLTDFYITCNGHLA-DLEEKLQDG---RTYSIVPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWI 116
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Xenopus
Match: sf3a3 (splicing factor 3a subunit 3 [Source:NCBI gene;Acc:549872])

HSP 1 Score: 49.6766 bits (117), Expect = 6.462e-6
Identity = 25/49 (51.02%), Postives = 32/49 (65.31%), Query Frame = 3 
Query:  834 ADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKG 980
            A ++L +  S   L + G D +K+ LM  GLK GGTL ERAQRL+S KG
Sbjct:  242 AHLDLSAFSSWEELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKG 290
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Xenopus
Match: sf3a3 (splicing factor 3a subunit 3 [Source:NCBI gene;Acc:549872])

HSP 1 Score: 49.6766 bits (117), Expect = 6.491e-6
Identity = 25/49 (51.02%), Postives = 32/49 (65.31%), Query Frame = 3 
Query:  834 ADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKG 980
            A ++L +  S   L + G D +K+ LM  GLK GGTL ERAQRL+S KG
Sbjct:  238 AHLDLSAFSSWEELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKG 286
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Xenopus
Match: sf3a3 (splicing factor 3a subunit 3 [Source:NCBI gene;Acc:549872])

HSP 1 Score: 49.6766 bits (117), Expect = 6.775e-6
Identity = 25/49 (51.02%), Postives = 32/49 (65.31%), Query Frame = 3 
Query:  834 ADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKG 980
            A ++L +  S   L + G D +K+ LM  GLK GGTL ERAQRL+S KG
Sbjct:  242 AHLDLSAFSSWEELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKG 290
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Mouse
Match: Sde2 (SDE2 telomere maintenance homolog (S. pombe) [Source:MGI Symbol;Acc:MGI:2384788])

HSP 1 Score: 100.138 bits (248), Expect = 1.492e-22
Identity = 44/76 (57.89%), Postives = 57/76 (75.00%), Query Frame = 3 
Query:   87 FYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            F+ T NG +V+   +V    +     RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +W+
Sbjct:   47 FFVTCNGVLVNAGDKVQHGAVYSLEPRLRGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWV 122

HSP 2 Score: 50.8322 bits (120), Expect = 2.111e-6
Identity = 24/49 (48.98%), Postives = 33/49 (67.35%), Query Frame = 3 
Query:  840 INLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT 986
            ++L +  S   L + G + +K +LM  GLK GGTL ERA RL+SV+GLT
Sbjct:  382 VDLSAFSSAAELESLGLERLKCELMVLGLKCGGTLQERAARLFSVRGLT 430
[Close]
BLAST of Replication stress response regulator SDE2 vs. UniProt/SwissProt
Match: sp|Q8K1J5|SDE2_MOUSE (Replication stress response regulator SDE2 OS=Mus musculus OX=10090 GN=Sde2 PE=1 SV=1)

HSP 1 Score: 100.138 bits (248), Expect = 9.857e-22
Identity = 44/76 (57.89%), Postives = 57/76 (75.00%), Query Frame = 3 
Query:   87 FYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            F+ T NG +V+   +V    +     RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +W+
Sbjct:   47 FFVTCNGVLVNAGDKVQHGAVYSLEPRLRGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWV 122
[Close]
BLAST of Replication stress response regulator SDE2 vs. UniProt/SwissProt
Match: sp|Q5RET9|SDE2_PONAB (Replication stress response regulator SDE2 OS=Pongo abelii OX=9601 GN=SDE2 PE=2 SV=1)

HSP 1 Score: 99.3673 bits (246), Expect = 1.917e-21
Identity = 43/77 (55.84%), Postives = 56/77 (72.73%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            NF+   NG +++    V    +     RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +W+
Sbjct:   46 NFFVKCNGALIYTSDTVQHGAVYSLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWV 122
[Close]
BLAST of Replication stress response regulator SDE2 vs. UniProt/SwissProt
Match: sp|Q6IQ49|SDE2_HUMAN (Replication stress response regulator SDE2 OS=Homo sapiens OX=9606 GN=SDE2 PE=1 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 3.413e-21
Identity = 43/77 (55.84%), Postives = 56/77 (72.73%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            NF+   NG +++    V    +     RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +W+
Sbjct:   46 NFFVKCNGALINTSDTVQHGAVYSLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWV 122
[Close]
BLAST of Replication stress response regulator SDE2 vs. UniProt/SwissProt
Match: sp|Q7T293|SDE2_DANRE (Replication stress response regulator SDE2 OS=Danio rerio OX=7955 GN=sde2 PE=2 SV=2)

HSP 1 Score: 98.5969 bits (244), Expect = 3.504e-21
Identity = 47/81 (58.02%), Postives = 63/81 (77.78%), Query Frame = 3 
Query:   81 SNFYYTFNGFIV--HDLAEVPINGIVQK-HYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            ++FY + NG +   +DL +   +G+V +   RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +WL
Sbjct:   39 TDFYVSSNGRLSRSNDLLQ---SGVVYRLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKEMAEWL 116

HSP 2 Score: 58.5362 bits (140), Expect = 4.463e-8
Identity = 41/113 (36.28%), Postives = 58/113 (51.33%), Query Frame = 3 
Query:  753 LEKYAVETSKTNGDISK-SEESVKEVLFAD----------------INLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT--EYPASLLVGAVRTKRR 1034
            +EK A E  KT  ++ K +EES  E+  +                 ++L SV     L   G + +K +LM RG+K GGTL ERA RL+SVKGLT  +   SLL    + K++
Sbjct:  355 VEKMAEEVQKTAEEVQKKTEESTAEISPSSSIPEEKSQVLSQVEDPLDLLSVSGPEQLEALGLERLKKELMERGMKCGGTLQERAARLFSVKGLTPDQIDPSLLAKPSKGKKK 467
[Close]
BLAST of Replication stress response regulator SDE2 vs. UniProt/SwissProt
Match: sp|Q07G43|SDE2_XENTR (Replication stress response regulator SDE2 OS=Xenopus tropicalis OX=8364 GN=sde2 PE=2 SV=1)

HSP 1 Score: 97.8265 bits (242), Expect = 6.935e-21
Identity = 50/86 (58.14%), Postives = 63/86 (73.26%), Query Frame = 3 
Query:   69 SIMDSNFYYTFNGFIVHDLAEVPING----IVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            +I  ++FY T NG +  DL E   +G    IV    RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +W+
Sbjct:   35 AIPLTDFYITCNGHLA-DLEEKLQDGRTYSIVP---RLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWI 116
[Close]
BLAST of Replication stress response regulator SDE2 vs. TrEMBL
Match: A0A183PID0 (Sde2_N_Ubi domain-containing protein OS=Schistosoma mattheei OX=31246 GN=SMTD_LOCUS14116 PE=4 SV=1)

HSP 1 Score: 181.415 bits (459), Expect = 4.722e-50
Identity = 142/331 (42.90%), Postives = 193/331 (58.31%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLDNADSXXXXXXXXXXXXXXXXXXXXDQGPSAKLPYEDRSVEEQRKQIAEELQDAICEAFENRKQPK----------SLNKVNAKPKKI-ILDVD-------SDIEXXXXXXXXXXXYIPTTNDNL--GNSAECGDGSSVLVESVSDDKLENEEVGNLEHFTESKPPLEKYAVETSKTNGDISKSEESVKEVLFADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT--EYPASLLV 1010
            + YYT+NG IV+D+ E+P   ++  HYRL GGKGGFGSMLRAIGSQIEKTTN EMCRDL+GRRMRDVN EK+LK+W   AD RER+K E Y+E+RRKR+ LL QG   +  + DR  E Q+++IA EL+ A+  A EN K+ K          S  ++NAK  ++ I ++D       SD E S+SSS    S +   +DNL   +  E    S+ ++ S+  D +       +E   ES+      + ET++                  D  L  V +  +L  +G D +K  LM RGLK GGTL ERA RL+S+K L+  +YPA LL+
Sbjct:   26 DVYYTYNGRIVNDVEEIPECALLNVHYRLRGGKGGFGSMLRAIGSQIEKTTNHEMCRDLSGRRMRDVNLEKKLKEWYATADERERKKAEEYIERRRKRQELLKQGLLPEHSFSDREYERQKRKIAYELRGALDIAIENVKKEKKQTEIQSVISSEKQLNAKRTRLWIEEMDKELPSGSSDEEFSASSSFDISSSLAKQDDNLPVKDDTEAKTDSTEILNSIKSDVI-------VEDKKESQSACRNTSKETAQP---------------LNDQQLREVDTAENLEVFGLDVLKATLMARGLKCGGTLKERASRLFSIKDLSSEQYPAKLLM 334
[Close]
BLAST of Replication stress response regulator SDE2 vs. TrEMBL
Match: A0A183K9E9 (Sde2_N_Ubi domain-containing protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS11632 PE=4 SV=1)

HSP 1 Score: 181.03 bits (458), Expect = 7.853e-50
Identity = 141/331 (42.60%), Postives = 193/331 (58.31%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLDNADSXXXXXXXXXXXXXXXXXXXXDQGPSAKLPYEDRSVEEQRKQIAEELQDAICEAFENRKQPK----------SLNKVNAKPKKI-ILDVD-------SDIEXXXXXXXXXXXYIPTTNDNL--GNSAECGDGSSVLVESVSDDKLENEEVGNLEHFTESKPPLEKYAVETSKTNGDISKSEESVKEVLFADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT--EYPASLLV 1010
            + YYT+NG IV+++ E+P   ++  HYRL GGKGGFGSMLRAIGSQIEKTTN EMCRDL+GRRMRDVN EK+LK+W   AD RER+K E Y+E+RRKR+ LL QG   +  + DR  E Q+++IA EL+ A+  A EN K+ K          S  ++NAK  ++ I ++D       SD E S+SSS    S +   +DNL   +  +    S+ ++ S+  D +       +E   ES+      + ET++                  D  L  V +  +L  +G D +K  LM RGLK GGTL ERA RL+S+K L+  +YPA LLV
Sbjct:   26 DVYYTYNGRIVNNMEEIPECALLNVHYRLRGGKGGFGSMLRAIGSQIEKTTNHEMCRDLSGRRMRDVNLEKKLKEWYATADERERKKAEEYIERRRKRQELLKQGLLPEHSFSDREYERQKRKIAYELRGALDIAIENVKKEKKQTEVQPVISSEKQLNAKRTRLWIEEMDKELSSGSSDEEFSASSSFDISSSLAKQDDNLPVKDDTKAKTDSTEILNSIKSDVI-------VEDKKESQSACRNTSKETAQP---------------LTDQQLREVDTAENLEVFGLDVLKATLMARGLKCGGTLKERASRLFSIKDLSSEQYPAKLLV 334
[Close]
BLAST of Replication stress response regulator SDE2 vs. TrEMBL
Match: A0A4Z2DVL9 (Replication stress response regulator SDE2 isoform 2 OS=Schistosoma japonicum OX=6182 GN=EWB00_004101 PE=4 SV=1)

HSP 1 Score: 180.259 bits (456), Expect = 1.309e-49
Identity = 140/332 (42.17%), Postives = 192/332 (57.83%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLDNADSXXXXXXXXXXXXXXXXXXXXDQGPSAKLPYEDRSVEEQRKQIAEELQDAICEAFENRKQPKSLNK---VNAKPKKIILD--------VDSDIEXXXXXXXXXXXYIPTTNDNLGNSAECGDGSSVLVESVSDDKLENEEVGNLEHFTESKPPLEKYAVETSKTN---GDISKSEESVKEVL-------FADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT--EYPASLLV 1010
            + YYTFNG IV+ + ++P  G +Q+HYRL GGKGGFGSMLRAIGSQIEKTTN EMCRDL+GRRMRDVN E++LK+W   AD R+R K E ++E+R+KR+ LL +G      + DR  E Q+++IA EL+ A+  A EN KQ +SL+K   +NAK  ++ ++          SD E  +SSSS +   +    D+L N  +CG          +D+  ++ E+                 ++ +K N    D  K  ESV+E+          D  L +V +   L T+G D +K  LM RGLK GGTL ERA RL+ VK L   +YP  LL 
Sbjct:   25 DVYYTFNGRIVNSIEDIPKYGRLQRHYRLRGGKGGFGSMLRAIGSQIEKTTNHEMCRDLSGRRMRDVNLERKLKEWYATADERKRRKWEEHVERRQKRQELLKKGLLPGHNFSDREYERQKRKIAYELRSALDTAIEN-KQTRSLSKERQLNAKRARLWIEEMDKALSSSSSDEELLASSSSDTFLSLVKQEDSLRN--KCG----------TDNTTDSTEI-----------------IDNTKINVITSDEDKVLESVREITSTEAIQPLTDQQLRNVDTSDSLETFGLDVLKATLMARGLKCGGTLKERAMRLFLVKDLNSDQYPVKLLA 326
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BLAST of Replication stress response regulator SDE2 vs. TrEMBL
Match: A0A4Z2DV80 (Replication stress response regulator SDE2 isoform 3 OS=Schistosoma japonicum OX=6182 GN=EWB00_004101 PE=4 SV=1)

HSP 1 Score: 180.259 bits (456), Expect = 1.631e-49
Identity = 140/332 (42.17%), Postives = 192/332 (57.83%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLDNADSXXXXXXXXXXXXXXXXXXXXDQGPSAKLPYEDRSVEEQRKQIAEELQDAICEAFENRKQPKSLNK---VNAKPKKIILD--------VDSDIEXXXXXXXXXXXYIPTTNDNLGNSAECGDGSSVLVESVSDDKLENEEVGNLEHFTESKPPLEKYAVETSKTN---GDISKSEESVKEVL-------FADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT--EYPASLLV 1010
            + YYTFNG IV+ + ++P  G +Q+HYRL GGKGGFGSMLRAIGSQIEKTTN EMCRDL+GRRMRDVN E++LK+W   AD R+R K E ++E+R+KR+ LL +G      + DR  E Q+++IA EL+ A+  A EN KQ +SL+K   +NAK  ++ ++          SD E  +SSSS +   +    D+L N  +CG          +D+  ++ E+                 ++ +K N    D  K  ESV+E+          D  L +V +   L T+G D +K  LM RGLK GGTL ERA RL+ VK L   +YP  LL 
Sbjct:   33 DVYYTFNGRIVNSIEDIPKYGRLQRHYRLRGGKGGFGSMLRAIGSQIEKTTNHEMCRDLSGRRMRDVNLERKLKEWYATADERKRRKWEEHVERRQKRQELLKKGLLPGHNFSDREYERQKRKIAYELRSALDTAIEN-KQTRSLSKERQLNAKRARLWIEEMDKALSSSSSDEELLASSSSDTFLSLVKQEDSLRN--KCG----------TDNTTDSTEI-----------------IDNTKINVITSDEDKVLESVREITSTEAIQPLTDQQLRNVDTSDSLETFGLDVLKATLMARGLKCGGTLKERAMRLFLVKDLNSDQYPVKLLA 334
[Close]
BLAST of Replication stress response regulator SDE2 vs. TrEMBL
Match: A0A430QPD3 (Sde2_N_Ubi domain-containing protein OS=Schistosoma bovis OX=6184 GN=DC041_0005772 PE=4 SV=1)

HSP 1 Score: 180.259 bits (456), Expect = 1.730e-49
Identity = 141/331 (42.60%), Postives = 192/331 (58.01%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLDNADSXXXXXXXXXXXXXXXXXXXXDQGPSAKLPYEDRSVEEQRKQIAEELQDAICEAFENRKQPK----------SLNKVNAKPKKI-ILDVD-------SDIEXXXXXXXXXXXYIPTTNDNL--GNSAECGDGSSVLVESVSDDKLENEEVGNLEHFTESKPPLEKYAVETSKTNGDISKSEESVKEVLFADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT--EYPASLLV 1010
            + YYT+NG IV+++ E+P   ++  HYRL GGKGGFGSMLRAIGSQIEKTTN EMCRDL+GRRMRDVN EK+LK+W   AD RER+K E Y+E+RRKR+ LL QG   +  + DR  E Q+++IA EL+ A+  A EN K+ K          S  ++NAK  ++ I ++D       SD E S+SSS    S +   +DNL   +  +    S+ ++ S+  D +       +E   ES+        ET++                  D  L  V +  +L  +G D +K  LM RGLK GGTL ERA RL+S+K L+  +YPA LLV
Sbjct:   34 DVYYTYNGRIVNNMEEIPECALLNVHYRLRGGKGGFGSMLRAIGSQIEKTTNHEMCRDLSGRRMRDVNLEKKLKEWYATADERERKKAEEYIERRRKRQELLKQGLLPEHSFSDREYERQKRKIAYELRGALDIAIENVKKEKKQTEVQPVISSEKQLNAKRTRLWIEEMDKELSSGSSDEEFSASSSFDISSSLAKQDDNLPVKDDTKAKTDSTEILNSIKSDVI-------VEDKKESQSACRNTTKETAQP---------------LTDQQLREVDTAENLEVFGLDVLKATLMARGLKCGGTLKERASRLFSIKDLSSEQYPAKLLV 342
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Cavefish
Match: sde2 (SDE2 telomere maintenance homolog [Source:NCBI gene;Acc:103023323])

HSP 1 Score: 100.523 bits (249), Expect = 5.942e-23
Identity = 45/81 (55.56%), Postives = 57/81 (70.37%), Query Frame = 3 
Query:   72 IMDSNFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            I   + Y + NG I     ++    + +   RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + DWL
Sbjct:   36 IPSEDCYVSSNGRISDQDHKLQAGAVYRLELRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKEMADWL 116

HSP 2 Score: 54.6842 bits (130), Expect = 9.060e-8
Identity = 25/49 (51.02%), Postives = 35/49 (71.43%), Query Frame = 3 
Query:  840 INLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT 986
            ++L  V  V  L+  G + +K +LM+RG+K GGTL ERA RL+SVKGL+
Sbjct:  340 LDLLCVSGVEDLVALGLERLKEELMQRGMKCGGTLQERAARLFSVKGLS 388
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Cavefish
Match: sf3a3 (splicing factor 3a, subunit 3 [Source:ZFIN;Acc:ZDB-GENE-040908-1])

HSP 1 Score: 48.9062 bits (115), Expect = 6.495e-6
Identity = 25/49 (51.02%), Postives = 32/49 (65.31%), Query Frame = 3 
Query:  834 ADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKG 980
            A ++L +  S   L + G D +K+ LM  GLK GGTL ERAQRL+S KG
Sbjct:  320 AHLDLSAFSSWEELASLGLDRLKSALMALGLKCGGTLEERAQRLFSTKG 368
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Sea Lamprey
Match: sde2 (SDE2 telomere maintenance homolog (S. pombe) [Source:NCBI gene;Acc:550448])

HSP 1 Score: 72.4034 bits (176), Expect = 3.590e-14
Identity = 43/77 (55.84%), Postives = 55/77 (71.43%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            + +   NG +  D   V      + H +L GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +WL
Sbjct:   42 DVFVLCNGRLARDEDVVVPACCYRLHAKLLGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNSEKAMAEWL 118

HSP 2 Score: 54.6842 bits (130), Expect = 1.520e-8
Identity = 29/65 (44.62%), Postives = 41/65 (63.08%), Query Frame = 3 
Query:  789 GDISKSEESVKEVLFADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGL 983
            G  S+S   V   + A+++L ++ SV  L   G + +K  LM RG+K GGTL ERA RLYSV+G+
Sbjct:  323 GGKSESTSGVSSEVTAEVDLMALSSVEELEALGLECLKAVLMARGMKCGGTLHERAARLYSVRGV 387
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Nematostella
Match: EDO33018 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STG5])

HSP 1 Score: 96.2857 bits (238), Expect = 4.779e-22
Identity = 47/84 (55.95%), Postives = 59/84 (70.24%), Query Frame = 3 
Query:   84 NFYYTFNGFIVHDLAEVPINGIVQKH-------YRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            +FY   NG +V      P +GI+           RL GGKGGFGSMLRAIG+QIEKTT+RE CRDL+GRRMRDVN+EK++ +W+
Sbjct:   37 DFYLLHNGHLV-----FPSDGILLAPDDTLRIIPRLVGGKGGFGSMLRAIGAQIEKTTSREACRDLSGRRMRDVNDEKKITEWV 115
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Nematostella
Match: EDO29934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T279])

HSP 1 Score: 47.3654 bits (111), Expect = 6.106e-6
Identity = 24/50 (48.00%), Postives = 31/50 (62.00%), Query Frame = 3 
Query:  834 ADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGL 983
            A ++L +  S   L + G D +K  L   GLK GGTL ERAQRL+S KG+
Sbjct:  242 AHLDLSAFSSPEELASLGLDRLKQALQALGLKCGGTLEERAQRLFSTKGV 291
[Close]
BLAST of Replication stress response regulator SDE2 vs. Ensembl Medaka
Match: sde2 (SDE2 telomere maintenance homolog [Source:NCBI gene;Acc:101173918])

HSP 1 Score: 100.523 bits (249), Expect = 3.434e-23
Identity = 45/79 (56.96%), Postives = 56/79 (70.89%), Query Frame = 3 
Query:   78 DSNFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWL 314
            + NFY T NG +      +      +   RL GGKGGFGSMLRA+G+QIEKTTNRE CRDL+GRR+RDVN+EK + +WL
Sbjct:   20 EPNFYVTTNGRLAPPQDPLQDGWTYRLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKEMAEWL 98

HSP 2 Score: 51.9878 bits (123), Expect = 5.332e-7
Identity = 28/67 (41.79%), Postives = 40/67 (59.70%), Query Frame = 3 
Query:  840 INLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLT--EYPASLLVGAVRTKRR 1034
            ++L  V SV  L   G D +K +L RRGLK GGTL ERA RL+SV+  +  +   +LL    + K++
Sbjct:  298 VDLSLVTSVQQLELLGPDVLKAELQRRGLKCGGTLQERAARLFSVRDFSPGQINPALLAKPTKAKKK 364
[Close]
BLAST of Replication stress response regulator SDE2 vs. Planmine SMEST
Match: SMESG000046900.1 (SMESG000046900.1)

HSP 1 Score: 576.63 bits (1485), Expect = 0.000e+0
Identity = 316/320 (98.75%), Postives = 318/320 (99.38%), Query Frame = 3 
Query:   75 MDSNFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLDNADSXXXXXXXXXXXXXXXXXXXXDQGPSAKLPYEDRSVEEQRKQIAEELQDAICEAFENRKQPKSLNKVNAKPKKIILDVDSDIEXXXXXXXXXXXYIPTTNDNLGNSAECGDGSSVLVESVSDDKLENEEVGNLEHFTESKPPLEKYAVETSKTNGDISKSEESVKEVLFADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLTEYPASLLVGAVRTKRR 1034
            MDSNFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLDNADSREREKLESYLEKRRKRKLLLDQGPSAKLPYEDRSVEEQRKQIAEELQDAICEAFENRKQPKSLNKVNAKPKKIILDVDSDIESSSSSSSKSPSYIPTTNDNLGNSAECGDG SVLVESVSDDKLENE+VGNLEHFTESKP LEKYAVETSKTNGDISKSEESVKEVLFADI+LGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLTEYPASLLVGAVRTKRR
Sbjct:    1 MDSNFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQIEKTTNREMCRDLNGRRMRDVNNEKRLKDWLDNADSREREKLESYLEKRRKRKLLLDQGPSAKLPYEDRSVEEQRKQIAEELQDAICEAFENRKQPKSLNKVNAKPKKIILDVDSDIESSSSSSSKSPSYIPTTNDNLGNSAECGDGFSVLVESVSDDKLENEDVGNLEHFTESKPSLEKYAVETSKTNGDISKSEESVKEVLFADIDLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSVKGLTEYPASLLVGAVRTKRR 320
The following BLAST results are available for this feature:
BLAST of Replication stress response regulator SDE2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
SDE27.107e-2255.84SDE2 telomere maintenance homolog [Source:HGNC Sym... [more]
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CG59863.084e-2169.49gene:FBgn0043455 transcript:FBtr0084535[more]
CG59863.084e-2169.49gene:FBgn0043455 transcript:FBtr0321261[more]
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sde24.642e-2258.02SDE2 telomere maintenance homolog (S. pombe) [Sour... [more]
sde27.061e-2258.02SDE2 telomere maintenance homolog (S. pombe) [Sour... [more]
sf3a35.287e-651.02splicing factor 3a, subunit 3 [Source:ZFIN;Acc:ZDB... [more]
sf3a35.405e-651.02splicing factor 3a, subunit 3 [Source:ZFIN;Acc:ZDB... [more]
sf3a35.405e-651.02splicing factor 3a, subunit 3 [Source:ZFIN;Acc:ZDB... [more]
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sde21.446e-2156.98SDE2 telomere maintenance homolog (S. pombe) [Sour... [more]
sde21.451e-2156.98SDE2 telomere maintenance homolog (S. pombe) [Sour... [more]
sf3a36.462e-651.02splicing factor 3a subunit 3 [Source:NCBI gene;Acc... [more]
sf3a36.491e-651.02splicing factor 3a subunit 3 [Source:NCBI gene;Acc... [more]
sf3a36.775e-651.02splicing factor 3a subunit 3 [Source:NCBI gene;Acc... [more]
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Sde21.492e-2257.89SDE2 telomere maintenance homolog (S. pombe) [Sour... [more]
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BLAST of Replication stress response regulator SDE2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8K1J5|SDE2_MOUSE9.857e-2257.89Replication stress response regulator SDE2 OS=Mus ... [more]
sp|Q5RET9|SDE2_PONAB1.917e-2155.84Replication stress response regulator SDE2 OS=Pong... [more]
sp|Q6IQ49|SDE2_HUMAN3.413e-2155.84Replication stress response regulator SDE2 OS=Homo... [more]
sp|Q7T293|SDE2_DANRE3.504e-2158.02Replication stress response regulator SDE2 OS=Dani... [more]
sp|Q07G43|SDE2_XENTR6.935e-2158.14Replication stress response regulator SDE2 OS=Xeno... [more]
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BLAST of Replication stress response regulator SDE2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A183PID04.722e-5042.90Sde2_N_Ubi domain-containing protein OS=Schistosom... [more]
A0A183K9E97.853e-5042.60Sde2_N_Ubi domain-containing protein OS=Schistosom... [more]
A0A4Z2DVL91.309e-4942.17Replication stress response regulator SDE2 isoform... [more]
A0A4Z2DV801.631e-4942.17Replication stress response regulator SDE2 isoform... [more]
A0A430QPD31.730e-4942.60Sde2_N_Ubi domain-containing protein OS=Schistosom... [more]
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
sde25.942e-2355.56SDE2 telomere maintenance homolog [Source:NCBI gen... [more]
sf3a36.495e-651.02splicing factor 3a, subunit 3 [Source:ZFIN;Acc:ZDB... [more]
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
sde23.590e-1455.84SDE2 telomere maintenance homolog (S. pombe) [Sour... [more]
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO330184.779e-2255.95Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO299346.106e-648.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Replication stress response regulator SDE2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
sde23.434e-2356.96SDE2 telomere maintenance homolog [Source:NCBI gen... [more]
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BLAST of Replication stress response regulator SDE2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000046900.10.000e+098.75SMESG000046900.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30030187 ID=SMED30030187|Name=Replication stress response regulator SDE2|organism=Schmidtea mediterranea sexual|type=transcript|length=1207bp
CCGATCTCAACATTTTAATTAATTTAAATTTGAAAAATTTATAAATAAAT
CAAAACTATTTTTTATTAAGTATTATGGATTCGAATTTTTATTACACGTT
TAATGGATTTATTGTTCATGATTTAGCTGAAGTACCTATTAATGGTATTG
TTCAAAAGCATTATCGATTGTTTGGTGGTAAAGGTGGTTTTGGGTCTATG
TTACGAGCAATTGGATCTCAAATTGAAAAGACCACTAACCGTGAAATGTG
TCGAGATTTAAATGGTAGACGGATGAGAGATGTAAATAATGAAAAGCGTT
TGAAAGATTGGCTTGATAATGCTGATTCTAGGGAACGCGAGAAATTAGAA
TCATATTTAGAAAAACGAAGAAAACGAAAGTTGTTGTTAGATCAAGGTCC
AAGTGCAAAATTACCATATGAAGACAGATCAGTAGAAGAACAACGCAAAC
AAATTGCTGAAGAACTTCAAGATGCCATTTGTGAAGCTTTTGAAAACAGA
AAACAACCGAAAAGTCTTAATAAAGTAAATGCAAAACCAAAAAAAATTAT
TCTTGACGTTGATTCAGACATCGAATCTAGTAGTTCTAGTTCCTCTAAAT
CACCTAGTTACATTCCAACTACAAATGATAATTTAGGCAATTCTGCCGAA
TGTGGCGACGGTTCTAGTGTGTTAGTTGAATCAGTTAGCGATGATAAATT
GGAAAATGAAGAGGTAGGAAATCTAGAACATTTTACGGAAAGTAAACCAC
CACTTGAAAAATATGCTGTTGAAACCTCAAAAACTAATGGAGATATTTCT
AAATCAGAAGAAAGTGTGAAAGAAGTTTTGTTTGCTGATATCAATTTAGG
TAGTGTTGGCTCTGTGACTCACCTATTGACCTATGGAGCAGATTGGATAA
AAAATGATTTAATGCGCCGAGGACTAAAGAGTGGAGGTACGTTAATGGAA
AGGGCGCAGCGATTATATTCCGTCAAGGGTTTGACTGAATACCCAGCTAG
TTTATTAGTTGGTGCAGTTAGAACTAAGCGAAGATAGATGTTTTATATTT
TAATATAACTAGTAAAAATGTTAACTTTTTGATAAATCATATTGTACAAC
GAATATGCAAATTTATCTCTACGTGGTAAACACTTGAGACGAAATCTGTA
TCATTGTTTATTTTATAGCTCTAATGTTGCATTTATGTGTAATATAATGC
TGCCGAT
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protein sequence of SMED30030187-orf-1

>SMED30030187-orf-1 ID=SMED30030187-orf-1|Name=SMED30030187-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=321bp
MDSNFYYTFNGFIVHDLAEVPINGIVQKHYRLFGGKGGFGSMLRAIGSQI
EKTTNREMCRDLNGRRMRDVNNEKRLKDWLDNADSREREKLESYLEKRRK
RKLLLDQGPSAKLPYEDRSVEEQRKQIAEELQDAICEAFENRKQPKSLNK
VNAKPKKIILDVDSDIESSSSSSSKSPSYIPTTNDNLGNSAECGDGSSVL
VESVSDDKLENEEVGNLEHFTESKPPLEKYAVETSKTNGDISKSEESVKE
VLFADINLGSVGSVTHLLTYGADWIKNDLMRRGLKSGGTLMERAQRLYSV
KGLTEYPASLLVGAVRTKRR*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
GO:0003674molecular_function
Vocabulary: biological process
TermDefinition
GO:0006260DNA replication
GO:0007049cell cycle
GO:0051301cell division
GO:0008150biological_process
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR024974Sde2_N
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR024974Sde2, N-terminal ubiquitin domainPFAMPF13019Sde2_N_Ubicoord: 30..93
e-value: 5.8E-18
score: 65.3
NoneNo IPR availablePFAMPF13297Telomere_Sde2_2coord: 256..304
e-value: 1.3E-16
score: 59.9
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 164..187
NoneNo IPR availablePANTHERPTHR12786:SF1REPLICATION STRESS RESPONSE REGULATOR SDE2coord: 3..311
NoneNo IPR availablePANTHERPTHR12786SPLICING FACTOR SF3A-RELATEDcoord: 3..311