Neurexin-4

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQV----TYNTFQYFTKDISLGKDFYIGG---------GRAAVSSFQGCLRNIYINNVQVNY------DPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDG------------------SAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSS--NDFKKYIIIKVNNNGGITIEFDVGFTR--YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGR---------NFSQVSKLGFTGCIYRLQFNNIFPLK-MLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIP-----------DWQRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTN---QPDVAGKEW 4105
            + G   +DG WH V     +N   LT+  D+     T +  Q     +  G+ ++ GG               SFQGC++ I +++  VN        P +F +++    C++ID C+PN C+H   C+Q   +F C C  TGYSG  CH S    SC   + +  G Q+S    +D DGSG L P +V C+ +   + T IV H+ +    V G+ +P  + +  +  +A  D ++ +   + YCEQ +SY C  ++LL  P G         + WWVG+  +  +YWGG  PGIQKC CGI+  C+     CNCD D       + D+G L+ K  LPV++V +GDT    +G  + ++VGPLRC GD  + N  +F    S L+      E   D+ F FKT     V L+++ K++  F ++ ++    +  +F++G G +EI+      LND+ WH V  ERN K++ L +D   P   ++ P   +T     S+L VG +     G++GC  +L +NGV  DL+       G   GC+  CT     C N G+C E Y GY C+C  T Y G  C ++VGA F +G                  S V+   D  +      +E I   F T      LL +SS   DF   + + V   G + I +++G TR  Y +  D+  ++ N Q H++   R +  +T  +++D Y  +       L ++SD   + P  +++G+            + +  GFTGC+ R+QFN I PLK  L       +V + G  + E+NCG   +           +      + + D P              R   I+G ++AV+   IL  L+F  R     +G Y T EAKGA+  ++AD AI     N     D + KEW
Sbjct:  448 SSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQ-----VKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSF-ANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCE--AYKHLG-QTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWT-IVSHDLQMQTPVVGY-NPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPDG-------SPYTWWVGKANEKHYYWGGSGPGIQKCACGIERNCTDPKYYCNCDADY---KQWRKDAGFLSYKDHLPVSQVVVGDTDR--QGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKED--FIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDR-LPQQIRKAPTEGHTRLELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDF---LAVLVKPTGSLQIRYNLGGTREPYNIDVDH-RNMANGQPHSVNITRHE--KTIFLKLDHYPSVSYH----LPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGE-LVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTETIDESKKEW 1329          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIEGLSSISFKVTFRTFAVNGML-FYHVVDLMFTQFISLSINK 1475
            GAG WS  D +  Q++QVD   RK I+AIA QGR  S+++V  Y + +S  D    WK +    G  + F GN N + V    L +PI+AR+VRI P  WN    I +R E++GC Y      FDG   + YR     + ++T  D I   FKTS   G+IL+ EG Q DYIT+E+ +++L + +NLG+   + P      +  GS+LDD+ WH V I R  + +N+TLDR         +F +L+L+  I+ GG+  F+GK   S  +NF GC+E + ++G+ I   ARRK    +N                                    VGN+   C  P  +   + F +     + G++  + L S+SF+  FRT+  NG+L F H  D +    I L+ +K
Sbjct:   70 GAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYS--DTGRNWKPYHQD-GNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRFRN--KKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSN-QLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGI-PFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSN------------------------------------VGNLSFSCVEP--YTVPVFFNATSYLEVPGRLN-QDLFSVSFQ--FRTWNPNGLLVFSHFADNLGNVEIDLTESK 430          

Query:  480 NDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQ--FDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAE-GDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNI-LDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQ-NFIGCIEEMVFD----GLYIIRDARRKVNMAAN 1145
            N N V +T+L     AR  ++ P     +       F C+ +P+T    F+  S     L+ PGR  Q     + F+F+T N NGL++++   D    + I++  S++      G  +N+    M  I + +GS L+D QWH+V     E    +T+D  +     T+  + +        GG  N       SV+Q +F GC++ +  D     LY +  A+RK    AN
Sbjct:  341 NYNGVNITDL-----ARRKKLEPSNVGNLS------FSCV-EPYTVPVFFNATSY----LEVPGRLNQDLF-SVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKV------GVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEV--AQRKPGSFAN 546          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFT-KDISLGKDFYIGGG---------RAAVSSFQGCLRNIYINN-----VQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAV------------EITLD----YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVD-------------DYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            G + +DG+WHSV +   +N++T+  D          T   I  G  +Y GG             + +FQGC+R I+I+N     + V        S +    CS+ D C+PN C+H   C+Q   TF CNCS T Y+G  CH S    SC     R  G  ++    +D DGSG L P QV C+ +   I T+ V HNN +   V G      + + L Y     + L  ++  S +CEQ ++Y C  ++LL  P G         F WW+GR  +   YWGG  PG+Q+C+CG+  +C      CNCD D   +     D+G L+ K  LPVT++ + DT        +   +GPLRC GD  F N ++F    S L+ P   AE   D+ F FKTT  + V L+++  ++     +R+       +TF +  G   +E+VV +   LNDN WH VR ERN KE+ L +D N P + +E  +  +     +S+L VG + S   G++GC  +L +NG   DL+       G+  GC   C+   + C N G+C E ++GY C+C  +PY G  C +EV A F  G++V             I+L     Y+D   S  +E I + F T      LL ++S+  + ++++ +  NG + + + +      V T    +  N + H LK  R   G+   IQ+D             ++R+I+   +  ++ N          + +    ++ + +GF GC+  +Q+N+I PLK       +  V V GT + E++CG
Sbjct:  442 GSNLNDGLWHSVSINARRNRITLTLDDEAAPPAPDSTWVQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKDLISVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGSCSQSWTTFYCNCSDTSYTGATCHNSIYEQSCE--VYRHQG-NTAGFFYIDSDGSGPLGPLQVYCNITEDKIWTS-VQHNNTELTRVRGANPEKPYAMALDYG-GSMEQLEAVIDGSEHCEQEVAYHCRRSRLLNTPDG-------TPFTWWIGRSNERHPYWGGSPPGVQQCECGLDESCLDIQHFCNCDAD---KDEWTNDTGFLSFKDHLPVTQIVITDTDRS--NSEAAWRIGPLRCYGDRRFWNAVSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIKD----FIRLEISSPSEITFAIDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVD-NLPRSTRETSEEGHFRLQLNSQLFVGGTSSRQKGFLGCIRSLHLNGQKMDLEERAKVTSGVRPGCPGHCSSYGSICHNGGKCVEKHNGYLCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIYTDSAPS--KENIALSFVTTQAPSLLLFINSSS-QDFVVVLLCKNGSLQVRYHLNKEETHVFTIDADNFANRRMHHLKINRE--GRELTIQMDQQLRLSYNFSPEVEFRVIRSLTLGKVTEN----------LGLDSEVAKANAMGFAGCMSSVQYNHIAPLKAALRHATVAPVTVHGT-LTESSCG 1200          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGN 1151
            G G WS  D N QQ++Q+DL  R  ITA+A QGR GS+++V  Y + FS  D    WK ++      + F GN N ++V    L + + AR VR  P  WN    I +R E++GC YK   A FDG+S ++YR +Q  + + T  D I  +FK+   +G++ + EG + D+IT+E+ + RL + +NLG        S+ +    GS+LDD  WH V I R  K +N T+D+         +   L+++  +S GG+    GK G  + +NF GCIE + ++G+ II  A+R+ +    GN
Sbjct:   63 GTGGWSPADSNAQQWLQMDLGNRVEITAVATQGRYGSSDWVTSYSLMFS--DTGRNWKQYKQE-DSIWTFAGNMNADSVVHHKLLHSVRARFVRFVPLEWNPSGKIGMRVEVYGCSYKSDVADFDGRSSLLYRFNQ--KLMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLALHLNLGDSKARLSSSLPSAT-LGSLLDDQHWHSVLIERVGKQVNFTVDKHTQHFRTKGETDALDIDYELSFGGI-PVPGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYTGN 355          

Query:  693 IKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIH--LNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKV 1130
            I F FKT+ ++G+ L   G + D+I +E+          +   ++V    ++ ++ + S+L+DNQWH V   R  K+ ++ +D +      TS+  H  L LN  + VGG          S  + F+GCI  +  +G  +  + R KV
Sbjct:  815 ISFFFKTTALSGVFLENLGIK-DFIRLEISSPS-----EITFAIDVGNGPVELVVQSPSLLNDNQWHYVRAERNLKETSLQVDNLPRSTRETSEEGHFRLQLNSQLFVGGTS--------SRQKGFLGCIRSLHLNGQKMDLEERAKV 948          

Query: 1547 DLTADGRSFSDGMWHSVELYLTKNKLTVVAD-QVTYNTFQYFTKDISLGKDFYIGGG---------RAAVSSFQGCLRNIYINNVQVNY------DPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD----------------YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVG-FTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDD--YRIIKKSFISILSANSDARLDK-PTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNC 3802
            D+TA G   +DG WHSV L   KN L+V  D Q+         + I  G  +Y GG          ++ +  FQGC+R I I+   V+          NF S ++  +C + D C+PN C+H   C+Q   TF CNC+ TGY G  CH S    SC     R     +S    +D DGSG L PF + C+ +      TI+ HN   D+    + +P +         A  + L   + R+ +CEQ  +Y C  ++L+    G           WWVGR  +   YWGG  P +QKC CG++G C  +   CNCD D   +     D+G+L  K  LPVT++ + D T ++  +++   +GPL C GD  F N+ +F    S L+ P    E   D+ F FKTT S+ V L+++   +  F  + +R    +  +F++G G  EI      + NDN WH VR ERN KE+ L +D+  P T Q  P   +     +S+L VG + +   G++GC  +L +NG+  DL+        +  GC   C+     C N G+C E   G++C+C  + Y G  C  E+ A F  GS+V                     + D K+S   E I+  F+T      LL VSS  +K+Y+ + +  NG + I + +  +   +V      ++ + Q H +   R + G  + I++DD   R +  S  +  SA     L +   +  V ++ +     GFTGC+  +Q +++ PLK   +      V V+G  + E++C
Sbjct:  393 DITA-GVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNF-SDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSIYEQSCEAYKHR---GNTSGFYYIDSDGSGPLEPFLLYCNMT--ETAWTIIQHNG-SDLTRVRNTNPENPYAGFFEYVASMEQLQATINRAEHCEQEFTYYCKKSRLVNKQDG-------TPLSWWVGRTNETQTYWGGSSPDLQKCTCGLEGNCIDSQYYCNCDAD---RNEWTNDTGLLAYKEHLPVTKIVITD-TGRLHSEAA-YKLGPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIAD--FIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT-QPAPADGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS--REMIKFSFRTTRTPSLLLFVSSF-YKEYLSVIIAKNGSLQIRYKLNKYQEPDVVNFDFKNMADGQLHHIMINREE-GVVF-IEIDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQDTALAGAQGFTGCLSAVQLSHVAPLKAALHPSHPDPVTVTGH-VTESSC 1154          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLN 995
            GAG WS    N  Q++Q+DL ER  +TA+A QG  GS+ +V  Y + FSD      WK +R      + F GN+N ++V    L   I AR +R  P  WN    I +R E+FGC Y+      DGKS ++YR DQ  +++    D I  +FKT   +G++L+ EG   D+IT+++ R+RL + +N G     +  ++ N L  GS+LDD  WH V I+R  K +N T+D  +   +   +F  +NL+
Sbjct:   66 GAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYLLMFSDSGWN--WKQYRQE-DSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSEVVDLDGKSSLLYRFDQ--KSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGEAKLPSTSTLVN-LTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLD 307          

Query: 2621 ITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIID-ENAPVTHQEDPDRPYT--TFNFDS--ELIVGSS-QSFTDGYVGCFSNLIVNGVIQDLKSAITDPYG-------ISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREV 3238
            +TF    S L LP    E E    F F+T     ++L S  +       + + +G      +  G     I   V  LND  WH V     +    + +D + A       P++ Y+  T+ F    +   GS  +S   G+ GC   + ++G + DL S      G        S G + +C  N C + GEC + +S ++C C  T YRG  C   +
Sbjct:  324 VTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGV-ELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSI 541          

Query: 1547 DLTADGRSFSDGMWHSVELYLTKNKLTVVAD-QVTYNTFQYFTKDISLGKDFYIGGG---------RAAVSSFQGCLRNIYINNVQVNY------DPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD----------------YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVG-FTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDD--YRIIKKSFISILSANSDARLDK-PTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNC 3802
            D+TA G   +DG WHSV L   KN L+V  D Q+         + I  G  +Y GG          ++ +  FQGC+R I I+   V+          NF S ++  +C + D C+PN C+H   C+Q   TF CNC+ TGY G  CH S    SC     R     +S    +D DGSG L PF + C+ +      TI+ HN   D+    + +P +         A  + L   + R+ +CEQ  +Y C  ++L+    G           WWVGR  +   YWGG  P +QKC CG++G C  +   CNCD D   +     D+G+L  K  LPVT++ + D T ++  +++   +GPL C GD  F N+ +F    S L+ P    E   D+ F FKTT S+ V L+++   +  F  + +R    +  +F++G G  EI      + NDN WH VR ERN KE+ L +D+  P T Q  P   +     +S+L VG + +   G++GC  +L +NG+  DL+        +  GC   C+     C N G+C E   G++C+C  + Y G  C  E+ A F  GS+V                     + D K+S   E I+  F+T      LL VSS  +K+Y+ + +  NG + I + +  +   +V      ++ + Q H +   R + G  + I++DD   R +  S  +  SA     L +   +  V ++ +     GFTGC+  +Q +++ PLK   +      V V+G  + E++C
Sbjct:  368 DITA-GVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNF-SDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSIYEQSCEAYKHR---GNTSGFYYIDSDGSGPLEPFLLYCNMT--ETAWTIIQHNG-SDLTRVRNTNPENPYAGFFEYVASMEQLQATINRAEHCEQEFTYYCKKSRLVNKQDG-------TPLSWWVGRTNETQTYWGGSSPDLQKCTCGLEGNCIDSQYYCNCDAD---RNEWTNDTGLLAYKEHLPVTKIVITD-TGRLHSEAA-YKLGPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIAD--FIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT-QPAPADGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS--REMIKFSFRTTRTPSLLLFVSSF-YKEYLSVIIAKNGSLQIRYKLNKYQEPDVVNFDFKNMADGQLHHIMINREE-GVVF-IEIDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQDTALAGAQGFTGCLSAVQLSHVAPLKAALHPSHPDPVTVTGH-VTESSC 1129          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLN 995
            GAG WS    N  Q++Q+DL ER  +TA+A QG  GS+ +V  Y + FSD      WK +R      + F GN+N ++V    L   I AR +R  P  WN    I +R E+FGC Y+      DGKS ++YR DQ  +++    D I  +FKT   +G++L+ EG   D+IT+++ R+RL + +N G     +  ++ N L  GS+LDD  WH V I+R  K +N T+D  +   +   +F  +NL+
Sbjct:   41 GAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYLLMFSDSGWN--WKQYRQE-DSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSEVVDLDGKSSLLYRFDQ--KSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGEAKLPSTSTLVN-LTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLD 282          

Query: 2621 ITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIID-ENAPVTHQEDPDRPYT--TFNFDS--ELIVGSS-QSFTDGYVGCFSNLIVNGVIQDLKSAITDPYG-------ISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREV 3238
            +TF    S L LP    E E    F F+T     ++L S  +       + + +G      +  G     I   V  LND  WH V     +    + +D + A       P++ Y+  T+ F    +   GS  +S   G+ GC   + ++G + DL S      G        S G + +C  N C + GEC + +S ++C C  T YRG  C   +
Sbjct:  299 VTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGV-ELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSI 516          

Query: 1547 DLTADGRSFSDGMWHSVELYLTKNKLTVVAD-QVTYNTFQYFTKDISLGKDFYIGGG---------RAAVSSFQGCLRNIYINNVQVNY------DPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD----------------YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVG-FTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDD--YRIIKKSFISILSANSDARLDK-PTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNC 3802
            D+TA G   +DG WHSV L   KN L+V  D Q+         + I  G  +Y GG          ++ +  FQGC+R I I+   V+          NF S ++  +C + D C+PN C+H   C+Q   TF CNC+ TGY G  CH S    SC     R     +S    +D DGSG L PF + C+ +      TI+ HN   D+    + +P +         A  + L   + R+ +CEQ  +Y C  ++L+    G           WWVGR  +   YWGG  P +QKC CG++G C  +   CNCD D   +     D+G+L  K  LPVT++ + D T ++  +++   +GPL C GD  F N+ +F    S L+ P    E   D+ F FKTT S+ V L+++   +  F  + +R    +  +F++G G  EI      + NDN WH VR ERN KE+ L +D+  P T Q  P   +     +S+L VG + +   G++GC  +L +NG+  DL+        +  GC   C+     C N G+C E   G++C+C  + Y G  C  E+ A F  GS+V                     + D K+S   E I+  F+T      LL VSS  +K+Y+ + +  NG + I + +  +   +V      ++ + Q H +   R + G  + I++DD   R +  S  +  SA     L +   +  V ++ +     GFTGC+  +Q +++ PLK   +      V V+G  + E++C
Sbjct:  441 DITA-GVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNF-SDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSIYEQSCEAYKHR---GNTSGFYYIDSDGSGPLEPFLLYCNMT--ETAWTIIQHNG-SDLTRVRNTNPENPYAGFFEYVASMEQLQATINRAEHCEQEFTYYCKKSRLVNKQDG-------TPLSWWVGRTNETQTYWGGSSPDLQKCTCGLEGNCIDSQYYCNCDAD---RNEWTNDTGLLAYKEHLPVTKIVITD-TGRLHSEAA-YKLGPLLCQGDRSFWNSASFDTEASYLHFPTFHGELSADVSFFFKTTASSGVFLENLGIAD--FIRIELRSPTVVTFSFDVGNGPFEISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT-QPAPADGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMTLDLEERAQVTPEVQPGCRGHCSSYGKLCRNGGKCRERPIGFFCDCTFSAYTGPFCSNEISAYFGSGSSVIYNFQENYLLSKNSSSHAASFHGDMKLS--REMIKFSFRTTRTPSLLLFVSSF-YKEYLSVIIAKNGSLQIRYKLNKYQEPDVVNFDFKNMADGQLHHIMINREE-GVVF-IEIDDNRRRQVHLSSGTEFSAVKSLVLGRILEHSDVDQDTALAGAQGFTGCLSAVQLSHVAPLKAALHPSHPDPVTVTGH-VTESSC 1202          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDAR-RKVNMAANGN 1151
            GAG WS    N  Q++Q+DL ER  +TA+A QG  GS+ +V  Y + FSD      WK +R      + F GN+N ++V    L   I AR +R  P  WN    I +R E+FGC Y+      DGKS ++YR DQ  +++    D I  +FKT   +G++L+ EG   D+IT+++ R+RL + +N G     +  ++ N L  GS+LDD  WH V I+R  K +N T+D  +   +   +F  +NL+  IS GG+    GK      +NF GC+E + ++G+ II  A+ +K  + A GN
Sbjct:   66 GAGGWSPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSNWVTSYLLMFSDSGWN--WKQYRQE-DSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSEVVDLDGKSSLLYRFDQ--KSLSPIKDIISLKFKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGEAKLPSTSTLVN-LTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRHHFHARGEFNLMNLDYEISFGGI-PAPGKSVSFPHRNFHGCLENLYYNGVDIIDLAKQQKPQIIAMGN 359          

Query: 2558 KSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIID-ENAPVTHQEDPDRPYT--TFNFDS--ELIVGSS-QSFTDGYVGCFSNLIVNGVIQDLKSAITDPYG-------ISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREV 3238
            K  II +G +  +        +TF    S L LP    E E    F F+T     ++L S  +       + + +G      +  G     I   V  LND  WH V     +    + +D + A       P++ Y+  T+ F    +   GS  +S   G+ GC   + ++G + DL S      G        S G + +C  N C + GEC + +S ++C C  T YRG  C   +
Sbjct:  351 KPQIIAMGNVSFSCSQPQSMPVTFLSSRSYLALPDFSGEEEVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGV-ELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVDLISVQQGSLGNFSDLQIDSCGISDRCLPNYCEHGGECSQSWSTFHCNCTNTGYRGATCHNSI 589          

Query: 1574 SDGMWHSVELYLTKNKLTVVADQVTYNTFQ-YFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRT-FTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSS---KTVTVDLDGSGALTPFQVDCDFSVFNI----TTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDS--ELIVGS-SQSFTDGYVGCFSNLIVNGVIQDLK--SAITDPYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGF--------TRYEVTTDYIVDL--CNDQHHTLKAWRSDMGQTWNIQVDDYRI--IKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLK 3733
            +DG WHS  L +   ++ +  D  T    + +  + +S     +I        S  GC R++ I+   V       D ++  G C+  + C+PNPC++   C Q     + CNC   GY G+ CH +  P SC E        Q +   + V +D+DG G + P  V C      I     +TI+ H+  + ++V G   PG+ R  L Y  +  + ++ LV     C Q + Y C     L   G            W+  R  +    WG   P  + C C I G+C  N   CNCD          TD G+      LPVT + LG TT   +  S  + +GPL+C   + FD  +TFS  ++ L     F +  FD+    K + S   IL   S  +  +F + + +G  +    N G   +I+    +  +D  +H + +E +     L +D               T+F   +    IVGS ++  + G+ G   N+ + GV   L   +      G++IG +  C  + C N G+C + Y GY C+C +TP+ G  C +E G     GS+++I      Q  +       I  +T  +  T+L+  +        + V++NG + +    GF         R+ ++ D + D+  C  +HH            +N+ VD  ++  I+ ++    S N    LD+                 F GC+ R+Q  + FPLK
Sbjct:  370 ADGAWHSFSLRIRGVRMEIDIDGYTVLWLEGHEVRRVSQRLSNFI-------LSASGCYRSVTIDLTSVR-----VDGNVTRGECTFQEKCLPNPCENGGGCVQSALDDYVCNCK-EGYKGKNCHTTDLPHSCEEWVFTKGNKQKAVQGRKVLIDIDGGGEMQPINVTCKTERDEIGIDGVSTILEHDLLRPMIVTGDNKPGAVRYSLTYGIS-TEQMDRLVEGFEACSQFMRYTCRGGARLMTQGD-----ERSPSSWYSTRSDKHGLQWGEAPPYSRMCSCAINGSCLHNR-MCNCDSG-----EDSTDEGVNPYSQLLPVTGLFLGGTT---KSSSIEVEIGPLKCRNRATFD-PVTFSNRNAKLSGAQTFNQRTFDVSLHVKFSHSQMSILSWHSTDDLHWFHLYVNDGKIVGEVVNGGESQQIVSE--HRYDDGKFHAIYWEADSTGMFLKVDGQRKSVK--------TSFILPTVYMWIVGSRTEKGSTGFAGVIRNVHLCGVELALGQYARKETERGVAIGDDGYCRPDLCQNGGQCVDKYDGYVCDCSMTPFGGSDCTKEYGMMVPAGSSIQIPW----QNPAHQAMCHRIAIQTTSRNTTILRSKALFADSTFNMTVDDNGNLQMMAYDGFFFHFKRQSKRHNLSDDIMHDISFCASKHH------------FNVSVDGMQVITIEGNWTFFESFNVWHFLDE----------------NFEGCVSRIQTGSAFPLK 1044          

Query: 2498 KSDLPVTEVRLGDTTTKVEGKSSIINVGPLR--CTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVIL-QSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDE-----NAP-VTHQEDPDRPYTTFNFDSELIVGSSQ----SFTDGYVGCFSNLIVNGVIQDLKSAI--TDPYGISIGCNPK-----CTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNN 3418
            + D+  T + L +   +  G S +   G +   C   S   + ++F++  S L LP   + +   + F F+TT S+ +IL   V + N   +         L +  NLG G+  ++     ++D  WH V+ +R  +   +I+D      + P V+     D P    N  +  +V  S     +   GY GC  N+ +NGV   +      ++  GI +GC+       C  NPC N G+C +  + + C+C  T + G  C  E  A  ++G   ++ +  +  K+S + E+I+I F+T   +G L    +N     I + +N++
Sbjct:  426 RYDIDATRILLVNLADQSYGGSVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLSFHFRTTSSDGLILYHGVMQHNATDYVAFELIDSHLFMIINLGSGVVRLQTTSMKVSDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSVWSIALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNELDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHV-LAHTKVSQV-EHIKIRFRTTSSRGVLFDTGANGKNDKITVFLNDS 750          

Query: 2681 FDMIFLFKTTVSNAVILQSVSKQN-QQFFEVRIREG---FTLRVTFNLGYGIEIIEVVVNNLNDNFWH-VVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSS----QSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCN---PKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYS-DQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQH-HTLKAWRSDMGQTWNIQVD 3562
            F + F F+T + +A++  ++ K +  Q F +++  G   +T R +    +          +L+D  WH V+ ++  +    +++ +N+  T   D  +   +     +L  GS+       ++G+ GC S L +N    DL         ++ GC+    +C ++ C N G C +L+S   C+C LT + G  C         DGS   I  +Y+ +++ +T ++Y    F+T    G L+ +     + Y  I + N G +   +++G    + TT Y   + ND   H +K  R++   T  IQVD
Sbjct:  900 FRVQFKFQTLMRSALLFFTLPKHDYDQSFRLQMLNGRLKYTYRTSGQEFHTTSPKLPHRQHLSDMRWHNVLIYQDEKTHDHVLLVDNSSTTLIIDKIKKVES-KMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRMKVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQDYFTIFL-NKGYLNAHYNLG--NRDHTTSYHTRILNDGFPHVIKISRTEANMT--IQVD 1201          

Query: 1574 SDGMWHSVELYLTKNKLTVVADQVTYN-TFQYFTKDISLGKDFYIGG-------------GRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGT---CSM---IDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQ 1951
            SDG WH V+L       +V+ D +  + +    + ++ +    +IG                A    + GC++NI +N V      + F++S   G    CS+   +D+C PNPC++   C+++  +F C+CS T + G+ C   Q
Sbjct:  548 SDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSVWSIALQKGYTGCIKNIRMNGVSTKIG-QEFEASNSTGIELGCSLSNELDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQ 692          

Query:  594 CIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAE--GDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWR---NLTSDFIHLNLNRNISVGGLGN---------FAGKRGISVMQNFIGCIEEMVFDGLYII 1109
            C     T +FDG    ++    P     T  D   F F+T+  NG+++  E   DQ DY TI + +  L    NLG + +              +L+D   H ++I R E ++ + +D++   R      SD + LN+   IS+G   N            +R   +  ++ G I  +  +GL I+
Sbjct: 1092 CQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQ-DYFTIFLNKGYLNAHYNLGNRDHTTSYHT-------RILNDGFPHVIKISRTEANMTIQVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLDQKRLLRHRRNTEIFDSYQGEISGVNVNGLMIL 1269          

Query: 1565 RSFSDGMWHSVELYL---TKNKLTVVADQVTYNTFQYFTK-DISLGKDFYIGGGRAAVSS----FQGCLRNIYINNVQVN-YDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSS 2005
            +  SD  WH+V +Y    T + + +V +  T        K +  +    Y G     VS     F+GC+  + IN   ++ Y+  +    +  G    I  CI + C +   C Q   +  C+CSLT +SG  C   QNP++    ++RF G  S+
Sbjct:  959 QHLSDMRWHNVLIYQDEKTHDHVLLVDNSSTTLIIDKIKKVESKMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRMKVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRC---QNPST----TVRFDGSPSA 1107          

Query: 2498 KSDLPVTEVRLGDTTTKVEGKSSIINVGPLR--CTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVIL-QSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDE-----NAP-VTHQEDPDRPYTTFNFDSELIVGSSQ----SFTDGYVGCFSNLIVNGVIQDLKSAI--TDPYGISIGCNPK-----CTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNN 3418
            + D+  T + L +   +  G S +   G +   C   S   + ++F++  S L LP   + +   + F F+TT S+ +IL   V + N   +         L +  NLG G+  ++     ++D  WH V+ +R  +   +I+D      + P V+     D P    N  +  +V  S     +   GY GC  N+ +NGV   +      ++  GI +GC+       C  NPC N G+C +  + + C+C  T + G  C  E  A  ++G   ++ +  +  K+S + E+I+I F+T   +G L    +N     I + +N++
Sbjct:  435 RYDIDATRILLVNLADQSYGGSVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLSFHFRTTSSDGLILYHGVMQHNATDYVAFELIDSHLFMIINLGSGVVRLQTTSMKVSDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSVWSIALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNELDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHV-LAHTKVSQV-EHIKIRFRTTSSRGVLFDTGANGKNDKITVFLNDS 759          

Query: 2681 FDMIFLFKTTVSNAVILQSVSKQN-QQFFEVRIREG---FTLRVTFNLGYGIEIIEVVVNNLNDNFWH-VVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSS----QSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCN---PKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYS-DQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQH-HTLKAWRSDMGQTWNIQVDD-----YRIIKKSFISIL 3601
            F + F F+T + +A++  ++ K +  Q F +++  G   +T R +    +          +L+D  WH V+ ++  +    +++ +N+  T   D  +   +     +L  GS+       ++G+ GC S L +N    DL         ++ GC+    +C ++ C N G C +L+S   C+C LT + G  C         DGS   I  +Y+ +++ +T ++Y    F+T    G L+ +     + Y  I + N G +   +++G    + TT Y   + ND   H +K  R++   T  IQVD      YR  + S + +L
Sbjct:  909 FRVQFKFQTLMRSALLFFTLPKHDYDQSFRLQMLNGRLKYTYRTSGQEFHTTSPKLPHRQHLSDMRWHNVLIYQDEKTHDHVLLVDNSSTTLIIDKIKKVES-KMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRMKVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQDYFTIFL-NKGYLNAHYNLG--NRDHTTSYHTRILNDGFPHVIKISRTEANMT--IQVDKLPSLRYRPKRASDLVLL 1228          

Query: 1574 SDGMWHSVELYLTKNKLTVVADQVTYN-TFQYFTKDISLGKDFYIGG-------------GRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGT---CSM---IDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQ 1951
            SDG WH V+L       +V+ D +  + +    + ++ +    +IG                A    + GC++NI +N V      + F++S   G    CS+   +D+C PNPC++   C+++  +F C+CS T + G+ C   Q
Sbjct:  557 SDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSVWSIALQKGYTGCIKNIRMNGVSTKIG-QEFEASNSTGIELGCSLSNELDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQ 701          

Query:  594 CIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAE--GDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWR---NLTSDFIHLNLNRNISVGGLGN---------FAGKRGISVMQNFIGCIEEMVFDGLYII 1109
            C     T +FDG    ++    P     T  D   F F+T+  NG+++  E   DQ DY TI + +  L    NLG + +              +L+D   H ++I R E ++ + +D++   R      SD + LN+   IS+G   N            +R   +  ++ G I  +  +GL I+
Sbjct: 1101 CQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQ-DYFTIFLNKGYLNAHYNLGNRDHTTSYHT-------RILNDGFPHVIKISRTEANMTIQVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLDQKRLLRHRRNTEIFDSYQGEISGVNVNGLMIL 1278          

Query: 1565 RSFSDGMWHSVELYL---TKNKLTVVADQVTYNTFQYFTK-DISLGKDFYIGGGRAAVSS----FQGCLRNIYINNVQVN-YDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSS 2005
            +  SD  WH+V +Y    T + + +V +  T        K +  +    Y G     VS     F+GC+  + IN   ++ Y+  +    +  G    I  CI + C +   C Q   +  C+CSLT +SG  C   QNP++    ++RF G  S+
Sbjct:  968 QHLSDMRWHNVLIYQDEKTHDHVLLVDNSSTTLIIDKIKKVESKMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRMKVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRC---QNPST----TVRFDGSPSA 1116          

Query: 2504 DLPVTEVRLGDTTTKVEGKSSIINVGPLR--CTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVIL-QSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDE-----NAP-VTHQEDPDRPYTTFNFDSELIVGSSQ----SFTDGYVGCFSNLIVNGVIQDLKSAI--TDPYGISIGCNPK-----CTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNN 3418
            D+  T + L +   +  G S +   G +   C   S   + ++F++  S L LP   + +   + F F+TT S+ +IL   V + N   +         L +  NLG G+  ++     ++D  WH V+ +R  +   +I+D      + P V+     D P    N  +  +V  S     +   GY GC  N+ +NGV   +      ++  GI +GC+       C  NPC N G+C +  + + C+C  T + G  C  E  A  ++G   ++ +  +  K+S + E+I+I F+T   +G L    +N     I + +N++
Sbjct:  437 DIDATRILLVNLADQSYGGSVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLSFHFRTTSSDGLILYHGVMQHNATDYVAFELIDSHLFMIINLGSGVVRLQTTSMKVSDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSVWSIALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNELDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHV-LAHTKVSQV-EHIKIRFRTTSSRGVLFDTGANGKNDKITVFLNDS 759          

Query: 2681 FDMIFLFKTTVSNAVILQSVSKQN-QQFFEVRIREG---FTLRVTFNLGYGIEIIEVVVNNLNDNFWH-VVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSS----QSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCN---PKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYS-DQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQH-HTLKAWRSDMGQTWNIQVDD-----YRIIKKSFISIL 3601
            F + F F+T + +A++  ++ K +  Q F +++  G   +T R +    +          +L+D  WH V+ ++  +    +++ +N+  T   D  +   +     +L  GS+       ++G+ GC S L +N    DL         ++ GC+    +C ++ C N G C +L+S   C+C LT + G  C         DGS   I  +Y+ +++ +T ++Y    F+T    G L+ +     + Y  I + N G +   +++G    + TT Y   + ND   H +K  R++   T  IQVD      YR  + S + +L
Sbjct:  909 FRVQFKFQTLMRSALLFFTLPKHDYDQSFRLQMLNGRLKYTYRTSGQEFHTTSPKLPHRQHLSDMRWHNVLIYQDEKTHDHVLLVDNSSTTLIIDKIKKVES-KMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRMKVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQDYFTIFL-NKGYLNAHYNLG--NRDHTTSYHTRILNDGFPHVIKISRTEANMT--IQVDKLPSLRYRPKRASDLVLL 1228          

Query: 1574 SDGMWHSVELYLTKNKLTVVADQVTYN-TFQYFTKDISLGKDFYIGG-------------GRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGT---CSM---IDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQ 1951
            SDG WH V+L       +V+ D +  + +    + ++ +    +IG                A    + GC++NI +N V      + F++S   G    CS+   +D+C PNPC++   C+++  +F C+CS T + G+ C   Q
Sbjct:  557 SDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSVWSIALQKGYTGCIKNIRMNGVSTKIG-QEFEASNSTGIELGCSLSNELDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQ 701          

Query:  594 CIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAE--GDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWR---NLTSDFIHLNLNRNISVGGLGN---------FAGKRGISVMQNFIGCIEEMVFDGLYII 1109
            C     T +FDG    ++    P     T  D   F F+T+  NG+++  E   DQ DY TI + +  L    NLG + +              +L+D   H ++I R E ++ + +D++   R      SD + LN+   IS+G   N            +R   +  ++ G I  +  +GL I+
Sbjct: 1101 CQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQ-DYFTIFLNKGYLNAHYNLGNRDHTTSYHT-------RILNDGFPHVIKISRTEANMTIQVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLDQKRLLRHRRNTEIFDSYQGEISGVNVNGLMIL 1278          

Query: 1565 RSFSDGMWHSVELYL---TKNKLTVVADQVTYNTFQYFTK-DISLGKDFYIGGGRAAVSS----FQGCLRNIYINNVQVN-YDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSS 2005
            +  SD  WH+V +Y    T + + +V +  T        K +  +    Y G     VS     F+GC+  + IN   ++ Y+  +    +  G    I  CI + C +   C Q   +  C+CSLT +SG  C   QNP++    ++RF G  S+
Sbjct:  968 QHLSDMRWHNVLIYQDEKTHDHVLLVDNSSTTLIIDKIKKVESKMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRMKVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRC---QNPST----TVRFDGSPSA 1116          

Query: 2504 DLPVTEVRLGDTTTKVEGKSSIINVGPLR--CTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVIL-QSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDE-----NAP-VTHQEDPDRPYTTFNFDSELIVGSSQ----SFTDGYVGCFSNLIVNGVIQDLKSAI--TDPYGISIGCNPK-----CTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNN 3418
            D+  T + L +   +  G S +   G +   C   S   + ++F++  S L LP   + +   + F F+TT S+ +IL   V + N   +         L +  NLG G+  ++     ++D  WH V+ +R  +   +I+D      + P V+     D P    N  +  +V  S     +   GY GC  N+ +NGV   +      ++  GI +GC+       C  NPC N G+C +  + + C+C  T + G  C  E  A  ++G   ++ +  +  K+S + E+I+I F+T   +G L    +N     I + +N++
Sbjct:  428 DIDATRILLVNLADQSYGGSVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLSFHFRTTSSDGLILYHGVMQHNATDYVAFELIDSHLFMIINLGSGVVRLQTTSMKVSDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSVWSIALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNELDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHV-LAHTKVSQV-EHIKIRFRTTSSRGVLFDTGANGKNDKITVFLNDS 750          

Query: 2681 FDMIFLFKTTVSNAVILQSVSKQN-QQFFEVRIREG---FTLRVTFNLGYGIEIIEVVVNNLNDNFWH-VVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSS----QSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCN---PKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYS-DQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQH-HTLKAWRSDMGQTWNIQVDD-----YRIIKKSFISIL 3601
            F + F F+T + +A++  ++ K +  Q F +++  G   +T R +    +          +L+D  WH V+ ++  +    +++ +N+  T   D  +   +     +L  GS+       ++G+ GC S L +N    DL         ++ GC+    +C ++ C N G C +L+S   C+C LT + G  C         DGS   I  +Y+ +++ +T ++Y    F+T    G L+ +     + Y  I + N G +   +++G    + TT Y   + ND   H +K  R++   T  IQVD      YR  + S + +L
Sbjct:  900 FRVQFKFQTLMRSALLFFTLPKHDYDQSFRLQMLNGRLKYTYRTSGQEFHTTSPKLPHRQHLSDMRWHNVLIYQDEKTHDHVLLVDNSSTTLIIDKIKKVES-KMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRMKVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQDYFTIFL-NKGYLNAHYNLG--NRDHTTSYHTRILNDGFPHVIKISRTEANMT--IQVDKLPSLRYRPKRASDLVLL 1219          

Query: 1574 SDGMWHSVELYLTKNKLTVVADQVTYN-TFQYFTKDISLGKDFYIGG-------------GRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGT---CSM---IDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQ 1951
            SDG WH V+L       +V+ D +  + +    + ++ +    +IG                A    + GC++NI +N V      + F++S   G    CS+   +D+C PNPC++   C+++  +F C+CS T + G+ C   Q
Sbjct:  548 SDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSSVWSIALQKGYTGCIKNIRMNGVSTKIG-QEFEASNSTGIELGCSLSNELDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQ 692          

Query:  594 CIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAE--GDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWR---NLTSDFIHLNLNRNISVGGLGN---------FAGKRGISVMQNFIGCIEEMVFDGLYII 1109
            C     T +FDG    ++    P     T  D   F F+T+  NG+++  E   DQ DY TI + +  L    NLG + +              +L+D   H ++I R E ++ + +D++   R      SD + LN+   IS+G   N            +R   +  ++ G I  +  +GL I+
Sbjct: 1092 CQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRTTQPNGVLISIECAADQ-DYFTIFLNKGYLNAHYNLGNRDHTTSYHT-------RILNDGFPHVIKISRTEANMTIQVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLDQKRLLRHRRNTEIFDSYQGEISGVNVNGLMIL 1269          

Query: 1565 RSFSDGMWHSVELYL---TKNKLTVVADQVTYNTFQYFTK-DISLGKDFYIGGGRAAVSS----FQGCLRNIYINNVQVN-YDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSS 2005
            +  SD  WH+V +Y    T + + +V +  T        K +  +    Y G     VS     F+GC+  + IN   ++ Y+  +    +  G    I  CI + C +   C Q   +  C+CSLT +SG  C   QNP++    ++RF G  S+
Sbjct:  959 QHLSDMRWHNVLIYQDEKTHDHVLLVDNSSTTLIIDKIKKVESKMSGKLYFGSNPLGVSRPSNGFRGCISTLRINENALDLYEDADSRMKVNRGCSGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRC---QNPST----TVRFDGSPSA 1107          

Query: 1571 FSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYD-PKNF--------DSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN-NLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKS-AITDPYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            F+DG WHS  + + KN+L +  DQ    T +  +  ++ G  +YI GG+   + F GC+R I ++    NY  P+++           +    C MID C PNPC+H+  C Q+ R F C+C  TGY+G VCH S NP SC  +      +Q    + +D+DGSG L PF V C+F       T + H+ E    V+G  +PGSF   ++Y+ A++  +  L+ RS  C Q +SY C +++L   P   G  R    F WW+ R  QP+ YW G +PG +KC+CGI G C   +  CNCD +         D G + +K  LPV  V+ GDT T ++ K     +GPLRC GD LF N +TF   D+ + LPP    +  D+   F+TT  N+VI  +    +  + ++ +  G  L+  +  G G   + V  + +LNDN WH V  ERNRKE+RL++D +     +E P  P    +  S+L++G++  + DGYVGC   L++NG + DLK  +    YGIS GC  +C  NPCLN G C E Y GY C+C  + ++G +C  E+G +    S +    + S +  ST+ E I +GF T   +G LL  SSN   +Y+ I+++N+G +   FD GF R E+           Q+H +   R + G T  ++VD+Y  ++ +F   + A++DA+ +   Y+Y+G+N S     GF GC+ R+QF++I+PLK++F   P  NV+  GT + E+ CG
Sbjct:  453 FNDGKWHSFVISIEKNRLILNIDQRPMTTTK--SMQVATGAQYYIAGGKDK-NGFVGCMRLISVDG---NYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALK-NVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYD-ANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFR---PFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSN---SLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTD--YIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPG-PVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFR--STIAENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPK-KHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNF--DIKASADAQFNNIQYMYIGKNESMTD--GFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCG 1184          

Query:  267 AWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIR 1112
            +WSA++ +  Q + +DL   + +T IA+QGR  SNE+V +Y + +   D+   +  +++P G   +F GNS+ N++       PI+A+ VRI P RW+  IS+R EL+GC Y      F+G   V Y L +    I +  + I+FRFKT+  NG+++Y+ G Q DY  +++  +++ + ++LG++V  +       L  GS+LDDN WHDV I R ++D+  ++DRV +   +  +F  LNLNR + +GG+ N   + G+ V QNF GC+E + F+    IR
Sbjct:   78 SWSAKNSDFDQRLIIDLGVVRNVTHIALQGRPHSNEYVTEYTISYGITDLE--FADYKEPGGNVKMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYGCDYISENLYFNGTGLVRYDLRR--EPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTS-------LSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNV--QEGLIVQQNFSGCLENIYFNSTNFIR 346          

Query: 1571 FSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYD-PKNF--------DSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN-NLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKS-AITDPYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            F+DG WHS  + + KN+L +  DQ    T +  +  ++ G  +YI GG+   + F GC+R I ++    NY  P+++           +    C MID C PNPC+H+  C Q+ R F C+C  TGY+G VCH S NP SC  +      +Q    + +D+DGSG L PF V C+F       T + H+ E    V+G  +PGSF   ++Y+ A++  +  L+ RS  C Q +SY C +++L   P   G  R    F WW+ R  QP+ YW G +PG +KC+CGI G C   +  CNCD +         D G + +K  LPV  V+ GDT T ++ K     +GPLRC GD LF N +TF   D+ + LPP    +  D+   F+TT  N+VI  +    +  + ++ +  G  L+  +  G G   + V  + +LNDN WH V  ERNRKE+RL++D +     +E P  P    +  S+L++G++  + DGYVGC   L++NG + DLK  +    YGIS GC  +C  NPCLN G C E Y GY C+C  + ++G +C  E+G +    S +    + S +  ST+ E I +GF T   +G LL  SSN   +Y+ I+++N+G +   FD GF R E+           Q+H +   R + G T  ++VD+Y  ++ +F   + A++DA+ +   Y+Y+G+N S     GF GC+ R+QF++I+PLK++F   P  NV+  GT + E+ CG
Sbjct:  453 FNDGKWHSFVISIEKNRLILNIDQRPMTTTK--SMQVATGAQYYIAGGKDK-NGFVGCMRLISVDG---NYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALK-NVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYD-ANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFR---PFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSN---SLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTD--YIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPG-PVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFR--STIAENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPK-KHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNF--DIKASADAQFNNIQYMYIGKNESMTD--GFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCG 1184          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIR 1112
            G  AW+  +     F+ +DL + +++  IA  GR  ++EFV +Y V++SD    E W+ + +P  +P +F GNS+ N++       PI+A+ VRI P RW+  IS+R EL+GC Y      F+G   V Y L +    I +  + I+FRFKT+  NG+++Y+ G Q DY  +++  +++ + ++LG++V  +       L  GS+LDDN WHDV I R ++D+  ++DRV +   +  +F  LNLNR + +GG+ N   + G+ V QNF GC+E + F+    IR
Sbjct:   75 GNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDG--EFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYGCDYISENLYFNGTGLVRYDLRR--EPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTS-------LSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNV--QEGLIVQQNFSGCLENIYFNSTNFIR 346          

Query: 1586 WHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGG-RAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRN------GTCSMIDLCI-PNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDF-SVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTE---VRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVIL-QSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFN-FDSELIVGSSQ-------SFTDGYVGCFSNLIVNGVIQDLKSAITDPYG-ISIGCNPKCTQNPCLNRGECYELYSGYYCEC 3196
            WHSVEL     ++    D   +   Q +    ++G    IG   ++A     GC+R+I IN   +  +P++   + R         C+ ID C  PN C+H   C       TC+C  TGY G+ CH ++   +C E++L   G   S    +D+DG+G   P  V CDF S+ N T TIV HN    V V    +   F   + Y       L EL+  S YC Q I Y C+ A+L            + A  +    +   + + G    G   C C +  TC   + +CNCD     +    +D G   D   L +T    ++  D   + +G+   I +GPL C   +     +TF+   S + +P      + D+ F F+TT   A++L Q   + +   F V +     L  TF L  G    E+V+N+   LN   WH +  + N+   R +I+ +    +Q     P   F  F+  + +G +        S   G +GCF  L+VNG I D+ S ++     I   C P C  +PC N  +C EL+S + C C
Sbjct:  756 WHSVELDYKLGEIRFTVD-YRHTLSQMYGLTFNIGDKLIIGSSLKSAAMGLVGCIRDIEINGHLI--EPRHVVKTERVVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELAL--LGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARE-SDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL----------ELHSATWFTSSAKNLTVDFLGNVKRG--ACPCSVNKTCVDPNQSCNCD---VKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGR---ITLGPLECVETNTQKYVVTFTTSQSYIEVP---GWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTGDDQLTFTFTLSTGT-TRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTD----YQMLDLLPEEEFGPFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSCVPSPCRNGAQCKELWSSFKCVC 1285          

Query:  597 IYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGD--QFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFI-HLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARR---KVN----MAANGNRNWQDV--LYYPPMNSRIWW 1205
            IY        G S V YR+      + +   +I   F+T+  +  + YA G+  +  YI   +    + V M+ G  V      M  +L     L    WH++ I   ++ +++ LD+ +    L +    ++  +  I  GG      K+G++   NF+G ++ + ++ + I+ + +R   KV+    + A    N  +V  + YP   S IWW
Sbjct:  478 IYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNV------MSTVLTDD--LTRGYWHNLTILHEQRTVSIILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWW 684          

Query: 2684 DMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVR-----FERNRKESRLIIDE----------------NAPVTHQE----DPDRP------YTTFN---FDSELIVGSS--QSFTDGYVGCFSNLIVNGVIQDL-----KSAITDPYGISIGCNPKCTQNPCLNRGECYELYSGYY--CECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQ-KISTLEEYIEIGFKTKDKQGT----LLQVSSNDFKKYIIIKVNNNGGITIEFD 3442
            D++   +T  +NA++L +    N  F  + I       + F   YG EI+ + +  L+D     ++       R  +E+R+ ++E                N P ++ E     P RP      Y  F+   +D   ++  +      +GY+GC   L +   + DL     ++      G+   C  KC   PC N G C E ++     C+C  T + G  C  E GA F   S ++   +     ++  +   +++ F + D +      LL  +  +   Y+++ + ++G + +E D
Sbjct: 1346 DLLINLRTYDTNALVLYANDHYNN-FVHLYI--SLNREIVFLYNYGDEIVNLTL--LDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQEGVLPNCQIKCDAEPCKNGGTCQEHFAEQLSTCDCEHTSFLGEFCSEEKGADFSGESTLQRKFELPGTGRVDYVR--LQLAFSSFDLRRANRIMLLMQTEAERSYYLLLAITSDGYLQLEED 1639          

Query: 1586 WHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGG-RAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRN------GTCSMIDLCI-PNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDF-SVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTE---VRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVIL-QSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFN-FDSELIVGSSQ-------SFTDGYVGCFSNLIVNGVIQDLKSAITDPYG-ISIGCNPKCTQNPCLNRGECYELYSGYYCEC 3196
            WHSVEL     ++    D   +   Q +    ++G    IG   ++A     GC+R+I IN   +  +P++   + R         C+ ID C  PN C+H   C       TC+C  TGY G+ CH ++   +C E++L   G   S    +D+DG+G   P  V CDF S+ N T TIV HN    V V    +   F   + Y       L EL+  S YC Q I Y C+ A+L            + A  +    +   + + G    G   C C +  TC   + +CNCD     +    +D G   D   L +T    ++  D   + +G+   I +GPL C   +     +TF+   S + +P      + D+ F F+TT   A++L Q   + +   F V +     L  TF L  G    E+V+N+   LN   WH +  + N+   R +I+ +    +Q     P   F  F+  + +G +        S   G +GCF  L+VNG I D+ S ++     I   C P C  +PC N  +C EL+S + C C
Sbjct:  756 WHSVELDYKLGEIRFTVD-YRHTLSQMYGLTFNIGDKLIIGSSLKSAAMGLVGCIRDIEINGHLI--EPRHVVKTERVVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELAL--LGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARE-SDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL----------ELHSATWFTSSAKNLTVDFLGNVKRG--ACPCSVNKTCVDPNQSCNCD---VKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGR---ITLGPLECVETNTQKYVVTFTTSQSYIEVP---GWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTGDDQLTFTFTLSTGT-TRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTD----YQMLDLLPEEEFGPFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSCVPSPCRNGAQCKELWSSFKCVC 1285          

Query:  597 IYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGD--QFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFI-HLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARR---KVN----MAANGNRNWQDV--LYYPPMNSRIWW 1205
            IY        G S V YR+      + +   +I   F+T+  +  + YA G+  +  YI   +    + V M+ G  V      M  +L     L    WH++ I   ++ +++ LD+ +    L +    ++  +  I  GG      K+G++   NF+G ++ + ++ + I+ + +R   KV+    + A    N  +V  + YP   S IWW
Sbjct:  478 IYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNV------MSTVLTDD--LTRGYWHNLTILHEQRTVSIILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWW 684          

Query: 2684 DMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVR-----FERNRKESRLIIDE----------------NAPVTHQE----DPDRP------YTTFN---FDSELIVGSS--QSFTDGYVGCFSNLIVNGVIQDL-----KSAITDPYGISIGCNPKCTQNPCLNRGECYELYSGYY--CECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQ-KISTLEEYIEIGFKTKDKQGT----LLQVSSNDFKKYIIIKVNNNGGITIEFD 3442
            D++   +T  +NA++L +    N  F  + I       + F   YG EI+ + +  L+D     ++       R  +E+R+ ++E                N P ++ E     P RP      Y  F+   +D   ++  +      +GY+GC   L +   + DL     ++      G+   C  KC   PC N G C E ++     C+C  T + G  C  E GA F   S ++   +     ++  +   +++ F + D +      LL  +  +   Y+++ + ++G + +E D
Sbjct: 1346 DLLINLRTYDTNALVLYANDHYNN-FVHLYI--SLNREIVFLYNYGDEIVNLTL--LDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQEGVLPNCQIKCDAEPCKNGGTCQEHFAEQLSTCDCEHTSFLGEFCSEEKGADFSGESTLQRKFELPGTGRVDYVR--LQLAFSSFDLRRANRIMLLMQTEAERSYYLLLAITSDGYLQLEED 1639          

Query: 1586 WHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGG-RAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRN------GTCSMIDLCI-PNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDF-SVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTE---VRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVIL-QSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFN-FDSELIVGSSQ-------SFTDGYVGCFSNLIVNGVIQDLKSAITDPYG-ISIGCNPKCTQNPCLNRGECYELYSGYYCEC 3196
            WHSVEL     ++    D   +   Q +    ++G    IG   ++A     GC+R+I IN   +  +P++   + R         C+ ID C  PN C+H   C       TC+C  TGY G+ CH ++   +C E++L   G   S    +D+DG+G   P  V CDF S+ N T TIV HN    V V    +   F   + Y       L EL+  S YC Q I Y C+ A+L            + A  +    +   + + G    G   C C +  TC   + +CNCD     +    +D G   D   L +T    ++  D   + +G+   I +GPL C   +     +TF+   S + +P      + D+ F F+TT   A++L Q   + +   F V +     L  TF L  G    E+V+N+   LN   WH +  + N+   R +I+ +    +Q     P   F  F+  + +G +        S   G +GCF  L+VNG I D+ S ++     I   C P C  +PC N  +C EL+S + C C
Sbjct:  756 WHSVELDYKLGEIRFTVD-YRHTLSQMYGLTFNIGDKLIIGSSLKSAAMGLVGCIRDIEINGHLI--EPRHVVKTERVVGEVALDNCNYIDPCKRPNTCEHGGKCFVKDDRVTCDCKHTGYIGKNCHFTKYRKTCEELAL--LGFTKSDVYLIDIDGNGVFPPAHVKCDFQSLENATKTIVEHNLPSQVDVRSARE-SDFSFNIRYREFSPHMLQELISHSLYCTQYIKYDCYRAQL----------ELHSATWFTSSAKNLTVDFLGNVKRG--ACPCSVNKTCVDPNQSCNCD---VKENKWNSDEGYYQDPQSLGITNMYFLQQKDMDDEAQGR---ITLGPLECVETNTQKYVVTFTTSQSYIEVP---GWRKGDIAFSFRTTGEKAILLFQPPIRPHYPSFMVALTGDDQLTFTFTLSTGT-TRELVINSHRRLNGGEWHKIWIDYNQYHVRFMINTD----YQMLDLLPEEEFGPFEGSMYIGGATFDLLKKLSVKAGLIGCFRGLVVNGEILDIYSYMSVHLSEIIKDCKPSCVPSPCRNGAQCKELWSSFKCVC 1285          

Query:  597 IYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGD--QFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFI-HLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARR---KVN----MAANGNRNWQDV--LYYPPMNSRIWW 1205
            IY        G S V YR+      + +   +I   F+T+  +  + YA G+  +  YI   +    + V M+ G  V      M  +L     L    WH++ I   ++ +++ LD+ +    L +    ++  +  I  GG      K+G++   NF+G ++ + ++ + I+ + +R   KV+    + A    N  +V  + YP   S IWW
Sbjct:  478 IYTATIITLRGASYVSYRIYDWKDRVHSSTRRISLMFRTNFDDSALFYASGESLKHQYIAASIKNQSVHVEMDFGDNV------MSTVLTDD--LTRGYWHNLTILHEQRTVSIILDQQQKVLELPATASGNMLFDPEIYFGGGPELHKKKGLASHNNFVGSLKYVYYNDISILYELQRGNPKVHYHGVLEAEFVENEVNVIPITYPFATSHIWW 684          

Query: 2684 DMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVR-----FERNRKESRLIIDE----------------NAPVTHQE----DPDRP------YTTFN---FDSELIVGSS--QSFTDGYVGCFSNLIVNGVIQDL-----KSAITDPYGISIGCNPKCTQNPCLNRGECYELYSGYY--CECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQ-KISTLEEYIEIGFKTKDKQGT----LLQVSSNDFKKYIIIKVNNNGGITIEFD 3442
            D++   +T  +NA++L +    N  F  + I       + F   YG EI+ + +  L+D     ++       R  +E+R+ ++E                N P ++ E     P RP      Y  F+   +D   ++  +      +GY+GC   L +   + DL     ++      G+   C  KC   PC N G C E ++     C+C  T + G  C  E GA F   S ++   +     ++  +   +++ F + D +      LL  +  +   Y+++ + ++G + +E D
Sbjct: 1346 DLLINLRTYDTNALVLYANDHYNN-FVHLYI--SLNREIVFLYNYGDEIVNLTL--LDDTLMASLKSIQVAIVRGEQETRMHVNEHSVSIDRGTLLLDEYANKPWSNPEKEVLSPHRPPAPPTEYFQFHVGGYDPANLLRPNVDAPALEGYIGCVRGLKIGAQLIDLADINERNIAPTQEGVLPNCQIKCDAEPCKNGGTCQEHFAEQLSTCDCEHTSFLGEFCSEEKGADFSGESTLQRKFELPGTGRVDYVR--LQLAFSSFDLRRANRIMLLMQTEAERSYYLLLAITSDGYLQLEED 1639          

Query: 1547 DLTADGRSFSDGMWHSVELYLTKNKLTVVADQ-----VTYNTFQYFTKDISLGKDFYIGGG-RAAVSSFQGCLRNIYINNVQVNYDP------KNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYN-TADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD----------------YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTR-YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGR---------NFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            D+TA G + +DG WH +EL + + +L V  DQ     V  + F      + LG     G G R   + FQGC+R I  +   V+          NF S ++   C ++D C PN C+H   C+Q   TF CNCS TGYSG  CH S    SC   + +  G  +S    +D+DGSG + P  + C+ S  +    ++ HNN +  L +     G  +    +N +AD + +  ++ +S +CEQ +SY C  ++LL  P G         F WWVG  G+   YWGG +PG Q+C CG+QG C      CNCD D         DSG+L  K  LPV  + LGD +    G  +   VGPL+C GD  F NT  F+K  S L+ P    E   D+ FLFKT+ S+ V L+++  ++  F  + +     +  +F++G G +++     + LND  WH VR ERN KE+ L +D++ P   Q+ P   +     +S+L VG + S   G++GC  +L +NG   DL+       G+S GC   C+     CLN G C E YSG+ C+C L+P+ G  C +E+ A F  G++V  T                  YSD  ++   E I + F+T      LL V+S  +++Y+ I +N NG + +++ +  +R  EV      +L N Q H +   R  + +T +IQVD +   K+ F    +  SD   +    + +G+            +++ LGFTGC+  +QFN+I PLK          V V+G+ + E+ CG
Sbjct:  407 DVTA-GVNLNDGQWHRLELAIRRGRLAVTVDQTDSSAVATSVFAAPDSVLFLGGCPGDGSGCRNPFNVFQGCMRLIRTDGALVDLIKVQQMLLGNF-SDLQMDVCGIVDRCSPNHCEHGGKCSQSWSTFHCNCSATGYSGATCHSSIYEASCE--AYKHKG-NTSGFYYIDVDGSGPIKPQLIYCNMS--DKAWMVIQHNNTE--LTKLKTSSGINQHLAHFNYSADAEQIRAVISQSEHCEQELSYHCRKSRLLNTPDGA-------PFSWWVGGSGEAHMYWGGAVPGSQQCACGLQGNCVHPEHFCNCDAD---SKDWSNDSGLLAHKEHLPVQSLALGDISRS--GSEAAYRVGPLQCYGDGNFWNTAYFNKETSYLHFPTFHGELSADISFLFKTSSSSGVFLENLGFKD--FIRIELSSPTEVVFSFDVGNGPLDVRVQTPSALNDERWHHVRAERNVKEASLCVDQH-PAAVQKAPADGHIHLQLNSQLFVGGTASRQKGFLGCIRSLKLNGRTLDLEERAAITPGVSAGCPGHCSSYGGLCLNHGSCVEKYSGFTCDCSLSPFTGTFCHKELSAFFKPGTSVTYTFKEPYELNRNISAQSSSIYSD--LTLRGENISLSFRTSQAPALLLYVNSY-YREYLSILLNRNGHLDVKYKLAHSREAEVFRASGRNLANGQLHRVSVQR--LAETLSIQVDQHE--KEEF----NLTSDTEFNAIKSIVIGKVLDSGEVDPEIGRLNALGFTGCLSVVQFNSISPLKAALLYPDTSPVIVTGS-LSESGCG 1165          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFR--DPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK--VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGN 1151
            GAG WS  D N  Q++++ L +R  IT ++ QGR GS+++V  Y + FS  D    W+ +R  D  G    F GNSN ++V +  L  P+VA+++RI P  WN    I +R E +GC Y+   A FDG + ++YR D PG     + D +   FKT   +GL+L+ E      +T+++F+ RL +++  G  ++        +   GS+LDD  WH V I R    +N T+D+      L   +    ++  ISVGG  + +G +     +NF GC+E + ++G+ +I  A+ K  +A  GN
Sbjct:   37 GAGGWSPLDSNKYQWLEIKLEQRTEITGVSSQGRYGSSDWVTRYLLMFS--DTGHNWRPYRQEDSIGA---FSGNSNADSVVMYKLQQPVVAQYLRILPLDWNPNGRIGLRLEAYGCQYRSDVAGFDGAAHLLYRPD-PGVNPADK-DMLSMNFKTMQSSGLLLHMEAHSGHTLTLDLFKGRLVLQLRKGRALSA---DFHPLWSVGSLLDDQHWHHVSIERVRGLVNFTVDKNTQQFQLPEYWSRSEIDE-ISVGG-SSPSGLQKSHSRRNFHGCLENVFYNGVSVIDGAKEK-RVAITGN 325          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQ-----VTYNTFQYFTKDISLGKDFYIGGG-RAAVSSFQGCLRNIYINNVQVNYDP------KNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYN-TADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD----------------YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            G + +DG WH +EL + + +L V  DQ     V  + F      + LG     G G R   + FQGC+R I  +   V+          NF S ++   C ++D C PN C+H   C+Q   TF CNCS TGYSG  CH S    SC     +     +S    +D+DGSG + P  + C+ S  +    ++ HNN +  L +     G  +    +N +AD + +  ++ +S +CEQ +SY C  ++LL  P G         F WWVG  G+   YWGG +PG Q+C CG+QG C      CNCD D         DSG+L  K  LPV  + LGD +    G  +   VGPL+C GD  F NT  F+K  S L+ P    E   D+ FLFKT+ S+ V L+++  ++  F  + +     +  +F++G G +++     + LND  WH VR ERN KE+ L +D++ P   Q+ P   +     +S+L VG + S   G++GC  +L +NG   DL+       G+S GC   C+     CLN G C E YSG+ C+C L+P+ G  C +E+ A F  G++V  T                  YSD  ++   E I + F+T      LL V+S  +++Y+ I +N N G+     +   R         +L N Q H +   R  + +T +IQ+        S + + S  +D+    P    +GR    ++ LGFTGC+  +QFN+I PLK          V V+G+ + E+ CG
Sbjct:  419 GVNLNDGQWHRLELAIRRGRLAVTVDQTDSSAVATSVFAAPDSVLFLGGCPGDGSGCRNPFNVFQGCMRLIRTDGALVDLIKVQQMLLGNF-SDLQMDVCGIVDRCSPNHCEHGGKCSQSWSTFHCNCSATGYSGATCHSSIYEASCEAYKHK---GNTSGFYYIDVDGSGPIKPQLIYCNMS--DKAWMVIQHNNTE--LTKLKTSSGINQHLAHFNYSADAEQIRAVISQSEHCEQELSYHCRKSRLLNTPDGA-------PFSWWVGGSGEAHMYWGGAVPGSQQCACGLQGNCVHPEHFCNCDAD---SKDWSNDSGLLAHKEHLPVQSLALGDISRS--GSEAAYRVGPLQCYGDGNFWNTAYFNKETSYLHFPTFHGELSADISFLFKTSSSSGVFLENLGFKD--FIRIELSSPTEVVFSFDVGNGPLDVRVQTPSALNDERWHHVRAERNVKEASLCVDQH-PAAVQKAPADGHIHLQLNSQLFVGGTASRQKGFLGCIRSLKLNGRTLDLEERAAITPGVSAGCPGHCSSYGGLCLNHGSCVEKYSGFTCDCSLSPFTGTFCHKELSAFFKPGTSVTYTFKEPYELNRNISAQSSSIYSD--LTLRGENISLSFRTSQAPALLLYVNSY-YREYLSILLNRN-GLKPSLPLSSGR---------NLANGQLHRVSVQR--LAETLSIQI-------YSDVCLCSCFADSGEVDPE---IGR----LNALGFTGCLSVVQFNSISPLKAALLYPDTSPVIVTGS-LSESGCG 1145          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFR--DPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK--VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHL--NLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGN 1151
            GAG WS  D N  Q++++ L +R  IT ++ QGR GS+++V  Y + FS  D    W+ +R  D  G    F GNSN ++V +  L  P+VA+++RI P  WN    I +R E +GC Y+   A FDG + ++YR D PG     + D +   FKT   +GL+L+ E      +T+++F+ RL + ++     +  P     +   GS+LDD  WH V I R    +N T+D+            HL   +   I +  +G   GK      +NF GC+E + ++G+ +I  A+ K  +A  GN
Sbjct:   48 GAGGWSPLDSNKYQWLEIKLEQRTEITGVSSQGRYGSSDWVTRYLLMFS--DTGHNWRPYRQEDSIGA---FSGNSNADSVVMYKLQQPVVAQYLRILPLDWNPNGRIGLRLEAYGCQYRSDVAGFDGAAHLLYRPD-PGVNPADK-DMLSMNFKTMQSSGLLLHMEAHSGHTLTLDLFKGRLVLALS----ADFHP-----LWSVGSLLDDQHWHHVSIERVRGLVNFTVDKNTQATQTKGCTSHLRNKIIIMIIMILMGRHGGKS--HSRRNFHGCLENVFYNGVSVIDGAKEK-RVAITGN 332          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISL-GKDFYIGGGRAAVS---------SFQGCLRNIYINNVQVN-----------YDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN-NLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKC-TQNP-CLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITL--------DYSDQ------KISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTR-YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIK------KSFISILSANSDARLDKPT-YVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQ 3808
            G++ SDG WH++ + +   ++++  D    +T Q   K+++L GK   IGG  + +S         ++QGC+R++ INN  +N           Y    FD       C + D C+PN C+H+  C+Q   TF C+CS TGY+G  CH S    SC   + R  G  +S   ++D DGSG L    V C+ +   +  T+V+HN+   V V+G        +   Y+T+  + L  LV RS +C+Q + Y C  ++L     G           WW+ R G+   YWGG +PG+Q+C C +   C   +  CNCD D   +++ + D+G+L+ K  LPVTE+ +GDT     G  +I  +G L C GD    N  +F +  S L+ P + AE   D+   FKTT  + V L+++  ++  F  + +     +  TF++G G  ++ V  +  LND  WH VR ERN +E+ L +D+  P+   E P   +T    +S+L +G + S   G++GC  +L +NG+  DL+       G+S GC   C +QN  C NRG+C E  SGY C+C  + Y G  C +EV  SF  GS+V  T         ++S Q      + S   E I   F T      LL V++   ++Y+ I + +NG + I + +   +  ++     ++L N + H ++  R   G+   +Q+D    +K      K  I+I S      L K T    V     Q    GF GC+  +QFN++ PLK    +     V V G  + E+NCG+
Sbjct:  336 GQALSDGQWHTLSISIAGYQVSLAVDDEPPSTMQ--MKEVALPGKSLLIGGCPSVLSNQGCRNPTMAYQGCMRSVVINNKPINFYLVQQGLLGNYSKLQFD------ICGIRDRCLPNYCEHDGVCSQSWSTFFCDCSGTGYTGATCHNSIFEPSCE--AHRLTG-SASGFFSIDPDGSGPLKSTVVYCNITDDKV-WTVVNHNSTAMVRVQGSSLQQPHVMTFNYSTS-LEQLRTLVGRSEHCQQEVVYLCRKSRLFNTWDG-------TPLSWWLDRAGERRTYWGGFLPGVQQCACSLDENCIDMNHFCNCDAD---RSSWENDTGILSYKEHLPVTEILVGDTNR--SGSEAIYRIGSLHCFGDRFLWNAASFYQESSYLHFPTLQAELSVDISLYFKTTAPSGVFLENLGTKD--FIRLELSGPSVVTFTFDVGNGPVVLTVKSHVPLNDKQWHYVRSERNVREASLQVDQ-LPLRFLEAPSEGHTHLQLNSQLFIGGTASRQRGFLGCIRSLNINGMTLDLEERAKMTPGVSSGCPGHCSSQNSLCHNRGKCIEKSSGYVCDCTHSAYGGPNCKKEVSVSFESGSSVTYTFQEPFSVMRNHSRQSSAIFAQSSNSRESIAFSFLTTQTPAMLLTVNTYH-QQYMAIILAHNGSLQIWYRLNREKDPDIFMPTSLNLANGELHRVQIHRE--GRDMYVQIDKDTNLKYSLSTDKELITIRSLT----LGKVTGRAGVDEEVLQAGSRGFIGCLSSVQFNHLAPLKAAILNRGSSLVNVLGNLV-ESNCGE 1094          

Query:  465 FFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDA-RRKVNMAANGN 1151
            F GN+N + V    L++ I  R +R  P  W+    + +R E++GC YK   A F+G+S ++YR +Q  ++  T  D I  RFK+   +G++++ EG + DYIT+E+ + RL + +NL       P S    +  G +LDD  WH V I R  K +N T+DR+            L ++  +S GG+    GK G  + +NF GC+E + ++G+ II  A RRK  + + GN
Sbjct:   22 FPGNTNSDGVVHHKLSHSIRTRFLRFLPMDWSPGGWMGLRVEVYGCAYKSDVADFNGRSSLLYRFNQ--KSTSTVKDVISLRFKSQRADGVLVHGEGQRGDYITLELHKGRLALHINLD-DAKTHPSSGHVSVFLGGLLDDQHWHSVLIERFNKQINFTVDRLTKHVRTGGLDDSLEVDYELSFGGI-PLPGKPGTFLRKNFHGCMENLYYNGVNIIDLAKRRKPQIYSVGN 249          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKD-FYIGGGRAAVSSF---------QGCLRNIYINNVQVNY------DPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN-NLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDL-KSAITDPYGISIGCNPKCTQNP-CLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD-----------------YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGF-TRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGR---------NFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNV 3766
            G++ +DG WHS+ + +   K+++  +     T +   +  +  +   YIGG     S+F         QGC R + INN  VN+      +  NF S I    C++ D C+PN C+H   C Q    F CNCS TGY+G  CH S    SC   + R  G QSS   T+DLDGSG L   QV+C  +   +  T+V H++ + + + G      F L   Y T     L  LV  S +C+Q + Y+C  ++L     G           WW+ R G    YWGG +PG+Q+C C + G C   +  CNCD D   Q T   D+G+L+ K  LP++E+ +GDT        + + +GPLRC G+  F N+ +F +  S L+ P + AE   D+   FKT+  + V L+++  ++  F  + +    T+  TF+LG G   + V     LND  WH +R ERN KE+ L +D       +  P++PY      S+L VG + S   G+VGC   L +NGV  DL + A T P G++ GC   CT +  C N G C E  S Y C+C  T + G  C + + ASF  GS+V  TL                  + D +++  +E +  GF T+     +L   + D + Y+ + + +NG + I + +    R E+ +     L + + H +K  R   GQ   +Q+D+  I ++  +S  SA S  R      V +GR            Q    GF GC+  +QFN   PLK    + PL  V
Sbjct:  446 GQNLNDGQWHSISVEVKGEKVSLTVNNQKPATMEITGRSQTPQRTTIYIGGCPLFQSNFNCENPGRGYQGCFRLLLINNHPVNFLQIQQENMGNF-SQISFDVCNIQDRCLPNLCEHGGQCIQSWDQFDCNCSGTGYTGATCHNSIYERSCE--AFRKTGSQSS-VFTIDLDGSGLLDHAQVNCTVAEDKV-WTVVGHDHMRPIDIRGSTPRSPFVLIFNY-TISPYHLRSLVTSSEHCQQEVIYRCRKSRLFDTWDG-------TPLSWWLDRDGVKRTYWGGFLPGVQQCSCSLDGNCRDMNYFCNCDAD---QDTWANDTGVLSYKDHLPLSEIAIGDTNRT--NSQAELQIGPLRCYGNRFFWNSASFYQESSYLHFPTLQAELSIDISLFFKTSAFSGVFLENLGVRD--FVRLELSSPSTMNFTFDLGDGPVTLTVRSPVALNDRQWHYIRAERNVKEASLQVDSLPLELTEAPPEKPY-RLQLSSQLFVGGTASRQRGFVGCLRALTINGVTLDLFERAKTTP-GVNSGCPGHCTSDSVCHNGGRCVEERSSYACDCTQTAFDGPHCRKALAASFESGSSVLYTLQEPFSGILNEEARRSPAGFHDAEVAKSQEKVSFGFLTRHVPALILMAHTLD-QNYMAVMLTSNGSLQIRYLMNKEKRTEMFSPKSGSLADGRFHWVKINRK--GQELLVQIDN-TITQQYSLSPGSALSPVR-----SVILGRIQGSDITDKELVQAGLRGFIGCLSSVQFNQATPLKAALQNSPLVTV 1195          

Query:  114 ERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQP---FLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNL-GAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLD-RVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIE-GLSSISFKVTFRTFAVNGMLF 1421
            E PL  S     +  S  ++SS +S   +  YA+L+  D         G G WS    + Q ++Q+DL +R  +T+IA QGR GS+++V  Y + +SD      W+    PY Q    + F GNS+ +TV    L + I  R++R+ P   +    + +R E++GC YK   A FDG+S ++YR +Q  ++  T  D I  RF++    G++++ EG + D++T+E+ R RL + +NL  AK      S   +L  GS+LDD+ WH V+I R  K +N T+D   + +R+L  +   L ++  +S GG+    GK G  + +NF GCIE + ++G+ +I  A+R+           +  +Y                          VGNV   C   SS    +TF  + S G +  +  +  + S+S ++ FRT+   G+LF
Sbjct:   30 EEPLLTS-----LPTSSFRNSSKYSDRRSPHYAKLNRRD---------GGGGWSPSGEDQQPWLQLDLRDRLKVTSIATQGRWGSSDWVARYQLHYSDSG--RTWR----PYRQEDVIWTFTGNSDTDTVVQHKLPHSIRTRYMRLLPIEGSPRGGMGLRLEVYGCTYKSDVADFDGRSALLYRFNQ--KSTSTVKDVISLRFRSHQAEGVLVHGEGQRGDFLTLELQRGRLILHLNLDDAKPQSGGRSSSVML--GSLLDDHHWHSVQIERFNKHVNFTVDGHTQHFRSLGQEDT-LEIDYELSFGGI-PLPGKPGTFLHENFHGCIENLNYNGVNVIDMAKRR-----------KPQIY-------------------------TVGNVTFSCSESSSV--AVTF--LSSTGSFLALPADYSMDSLSVRLQFRTWNQEGLLF 407          

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVS---SFQGCLRNIYINN-----VQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITL--------DYSDQKISTLEEYIEIGFKTKD--------KQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDY-IVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNF----------SQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTG-IRENNCGQXXXXXXXXXXXX----XXXXXXXXFNITTDIPDW-QRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAI---RYGKTNQPDVAGKEWW 4108
            A G   +DG WH V     +N   LT+  D+ +          I+ G  ++ GG   A     SFQGC++ I +++       V         ++    C++ID C+PN C+H   C+Q   +FTC C  TGY+G  CH S    SC   + +  G +SS    +D DGSG L PF+V C+ +   + TT+V+ N      V G        L L Y +A  + +  +   + +CEQ +SY C  ++LL  P G         + WWVGR  +  FYWGG  PGIQKC CGI+  CS +   CNCD D   Q   + DSG+L  K  LPV++V +GDT     G  + + VGPLRC GD  + N  +F+   S L+      E   D+ F FKT+    V L+++   N  F  + ++    +  +F++G G +E+       LND+ WH V  ERN KE+ L +D+      +  P + +T     S+L VG++     G++GC  +L +NGV  DL+       G+  GC+  CT     C N G+C E Y+GY C+C  T Y G  C ++VG  F  G+ V+  L           D+K       +E     +D           +LL   S+  + Y+ + + +NG + + + +G  R   T D    +L N Q HT+   R +  +   +Q+D Y  +  S    L   SD +      +++G+ F           + +  GF GC+ R+QFN+I PLK         +V VS  G + E+NCG   +                    PFN    IPD   R   I+G I+AV+   IL  L+F  R     +G Y T EAKG +  ++AD AI       T   D + KEW+
Sbjct:  414 ASGSGLNDGEWHDVRFLAKENFAMLTIDGDEASAVRTNSPVL-ITTGSTYHFGGKTRASPIQRSFQGCMQLIQVDDQLADLTAVEQGRIGAFENVSLDMCAIIDRCMPNHCEHGGRCSQTWDSFTCTCDGTGYTGATCHTSVYEQSCE--AYKHLG-RSSDAYWIDPDGSGPLGPFKVICNMTEDKVWTTVVN-NLPAQTAVTGSSRERRTVLQLNY-SASMEQVTAITNSAEHCEQHVSYACRMSRLLNTPDG-------TPYTWWVGRGNEKHFYWGGSAPGIQKCACGIERNCSDSKYYCNCDAD---QKQWRDDSGLLVYKDHLPVSQVAVGDTNRP--GSEAKLTVGPLRCHGDRSYWNAASFNTPSSYLHFSTFQGETSADISFYFKTSAPYGVFLENLG--NTDFIRLELKSPMVVSFSFDVGNGPVELNVHSPTPLNDDQWHRVSAERNTKEAILQLDQKYKEI-RPAPTQGHTRLELYSQLYVGAAGG-QRGFLGCIRSLKMNGVTLDLEERAKVTPGVKPGCSGHCTSFGMYCRNGGKCVEKYNGYSCDCTTTAYDGPFCSKDVGGFFEAGTLVKYNLVPEVLAAASSLDEKSIIHNLPVETNLTHEDLTFSFSTSTSPSLLVYVSSKTQDYMAVVLRHNGTLQLRYSLGGLREPFTIDIDQRNLANGQPHTVNISRVE--RDIEVQLDHYPAVTYS----LPEASDTQFTLVKSLFLGKVFETGYIDPVLIEKYNTPGFVGCLSRVQFNSIAPLKAALRSR--GSVSVSHQGKLVESNCGASPLTIPPMSAATDPWHLDAGADFPFNEERVIPDGVNRNSAIIGGIIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGGESSESADAAIIGTEANFTETIDESKKEWF 1283          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            GAG WS  D +  Q++QVDL  RK +TA+A QGR  S+++   Y + +SD      WK +    G  + F GNSN  +V   +L  P+VAR++RI P  W++   I +RFE++GC Y      FDG+  + YR     + ++   D I  +FKTS   G+IL+ EG Q DYIT+E+ R RL +++NLG+  + +     ++  +GS+LDD+ WH V I R  +++N TLD+         +F HL+L+  ++ GG+  ++GK  I   +NF GC+E + ++G  I   ARRK
Sbjct:   38 GAGGWSPLDSDHYQWLQVDLGSRKQVTAVATQGRYSSSDWTTRYRLLYSD--TGRNWKPYHQD-GNIWAFAGNSNTESVVRHDLQNPVVARYLRIIPLDWSEEGRIGLRFEIYGCPYWADVINFDGQGVISYRFKM--KKMKILKDVIALKFKTSESEGVILHGEGQQGDYITLELRRGRLLLQINLGSNQHGSILGHTSVT-SGSLLDDHHWHSVVIERYRRNVNFTLDQHTQHFRTNGEFDHLDLDYELTFGGM-PYSGKPVIGGRRNFKGCMESINYNGENITDLARRK 322          

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQV----TYNTFQYFTKDISLGKDFYIGGGRAAVS---------SFQGCLRNIYINNVQVNYDP-----KNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYN---TADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDT-TTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITL------------------DYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTR--YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSK---------LGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIPDWQRTGIIVGV---------IMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTN---QPDVAGKEW 4105
            + G   +DG WH V L   +N   LTV  D+     T +  Q+ T     G  ++ GG  +  +         SFQGC++ I++++  V+            ++I    C++ID C+PN C+H   CTQ   + TCNC  TGY+G  CH S    SC   + +  G +SS    +D DGSG L P +V C+ +   + TT+ H  + +  +V   LD      P+V N   +A  + ++ +   + YCEQ ISY C  ++LL  P G         + WWVG+  +   YWGG  PGIQKC CGI+  CS +   CNCD D   Q   + D+G L+ K  LPV++V +GDT  +  E K   ++V PLRC GD  + N  +F+   S L+      E   D+ F FKT+  + V L++  K +  F ++ ++    +   F++G G +E+I    + LND+ WH VR ERN KE+ L +D+  P    + P + +T     S+L VG++     G++GC  +L +NG+  DL+       G+  GC+  CT     C N G+C E Y+GY C+C  T Y G  C ++VG  F +G+ +                        S   I   +E +   F T      LL +SS   + Y+ + +  +G + I +++G T+  Y +      ++ N Q H++   RS  G+    Q+D Y       +  L + SD + + P  +++G+     +K          GF+GC+ R+QFN I PLK          V + G  + E+NCG   +           +        + + P+ +   I  GV         I+AV+   IL  L+F  R     +G Y T EAKGA+  DTAD AI     N     D + KEW
Sbjct:  447 SSGSGLNDGQWHEVRLTAKENFAILTVDGDEASSVRTNSPLQFQT-----GSRYFFGGFYSLSNYTDHSLLQHSFQGCMQLIHVDDQLVDLHAVEQGKHGSYANISIDMCAIIDRCVPNNCEHGGRCTQTWDSMTCNCEGTGYTGATCHNSIYELSCE--AYKHLG-KSSDWYWIDPDGSGPLGPLKVFCNMTEDKVWTTLFHDLSLQTPIVAASLDK-----PVVLNLNYSASMEQISAITGSAEYCEQYISYSCRMSRLLNTPDG-------NPYTWWVGKGNEKHHYWGGSSPGIQKCACGIERNCSDSKFHCNCDAD---QRQWRKDAGFLSYKDHLPVSQVVVGDTFRSSSEAK---LSVEPLRCHGDKNYWNAASFTTPSSYLHFSTFQGETSADISFYFKTSAPDGVFLENRGKTD--FIKLELKSNTEVSFAFDVGNGPVELIVRSPSPLNDDQWHRVRAERNVKEASLQVDQ-LPWQLHKAPTQGHTRLELYSQLFVGAAGD-QRGFLGCIRSLRMNGMTLDLEERAKITPGVKPGCSGHCTSFGMYCQNGGKCVEKYNGYTCDCSRTAYDGPYCNKDVGGYFEEGTWLRYNFHSASTAAVVSTKETGNIPQSSASDIGLAKEELLFSFSTTKSPCILLYISSYS-QDYLAVLLKASGILQIRYNLGGTKDPYNIDISDHKNMANGQPHSINITRS--GRNVIFQLDHY----PPAVYNLPSASDTQFNGPKALFLGKVIETGTKDQDIHSYNTPGFSGCLSRVQFNLIAPLKAALRSSNNSQVFIQGE-LVESNCGASPLTIPPMTSNTDPWHSE-----SPEFPNNEGQAIKDGVNRNSAIIGGIIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESADTADAAIINNDPNFTETIDESKKEW 1321          

Query:  102 SILPERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            S+  + PL +   +   + S IKS S      A  YA+L+  D          AG WS  D +  Q++QVD   RK I +IA QGR  S+++V  Y + +SD      WK +    G  + F GN N +TV   +L +P++AR+VRI P  WN+   I +R EL+GC Y      FDG S + YR     + ++T  D I  +FK+S   G+I + EG + DYIT+E+ +++L +++NLG+    +     ++  +GS+LDD+ WH V I R  +++N+TLDR         DF  L+L+  ++ GG+  F+GK   S  +NF GC+E + ++G+ I   ARRK
Sbjct:   31 SMKCDEPLVLGLPHQSFRSSSIKSGS-----YAPGYAKLNKRDE---------AGGWSPLDSDHYQWLQVDFGNRKQIRSIATQGRYSSSDWVSQYRMLYSD--TGRNWKPYHQD-GNIWAFPGNVNSDTVVRHDLQHPVIARYVRIVPLDWNEEGQIGLRTELYGCPYWADVINFDGNSGLSYRFKN--KKMKTLKDVISLKFKSSESEGVIFHGEGQEGDYITLELKKAKLVLQLNLGSNQYGSIYGHTSVT-SGSLLDDHHWHTVIIERHGRNINLTLDRHMQHFKTNGDFESLDLDFELTFGGM-PFSGKPSSSSRKNFKGCMESINYNGINITDLARRK 353          

Query:  675 QTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRV--KMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKV 1130
            +T AD I F FKTS  +G+ L   G + D+I +E     L+    +    +V    ++ I+ + S L+D+QWH V   R  K+ ++ +D++  ++ +  T     L L   + VG  G+   +RG      F+GCI  +  +G+ +  + R K+
Sbjct:  817 ETSAD-ISFYFKTSAPDGVFLENRG-KTDFIKLE-----LKSNTEVSFAFDVGNGPVELIVRSPSPLNDDQWHRVRAERNVKEASLQVDQLPWQLHKAPTQGHTRLELYSQLFVGAAGD---QRG------FLGCIRSLRMNGMTLDLEERAKI 954          

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQV----TYNTFQYFTKDISLGKDFYIGGGRAAVS---------SFQGCLRNIYINNVQVNYDP-----KNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYN---TADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDT-TTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITL------------------DYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTR--YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSK---------LGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIPDWQRTGIIVGV---------IMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTN---QPDVAGKEW 4105
            + G   +DG WH V L   +N   LTV  D+     T +  Q+ T     G  ++ GG  +  +         SFQGC++ I++++  V+            ++I    C++ID C+PN C+H   CTQ   + TCNC  TGY+G  CH S    SC   + +  G +SS    +D DGSG L P +V C+ +   + TT+ H  + +  +V   LD      P+V N   +A  + ++ +   + YCEQ ISY C  ++LL  P G         + WWVG+  +   YWGG  PGIQKC CGI+  CS +   CNCD D   Q   + D+G L+ K  LPV++V +GDT  +  E K   ++V PLRC GD  + N  +F+   S L+      E   D+ F FKT+  + V L++  K +  F ++ ++    +   F++G G +E+I    + LND+ WH VR ERN KE+ L +D+  P    + P + +T     S+L VG++     G++GC  +L +NG+  DL+       G+  GC+  CT     C N G+C E Y+GY C+C  T Y G  C ++VG  F +G+ +                        S   I   +E +   F T      LL +SS   + Y+ + +  +G + I +++G T+  Y +      ++ N Q H++   RS  G+    Q+D Y       +  L + SD + + P  +++G+     +K          GF+GC+ R+QFN I PLK          V + G  + E+NCG   +           +        + + P+ +   I  GV         I+AV+   IL  L+F  R     +G Y T EAKGA+  DTAD AI     N     D + KEW
Sbjct:  442 SSGSGLNDGQWHEVRLTAKENFAILTVDGDEASSVRTNSPLQFQT-----GSRYFFGGFYSLSNYTDHSLLQHSFQGCMQLIHVDDQLVDLHAVEQGKHGSYANISIDMCAIIDRCVPNNCEHGGRCTQTWDSMTCNCEGTGYTGATCHNSIYELSCE--AYKHLG-KSSDWYWIDPDGSGPLGPLKVFCNMTEDKVWTTLFHDLSLQTPIVAASLDK-----PVVLNLNYSASMEQISAITGSAEYCEQYISYSCRMSRLLNTPDG-------NPYTWWVGKGNEKHHYWGGSSPGIQKCACGIERNCSDSKFHCNCDAD---QRQWRKDAGFLSYKDHLPVSQVVVGDTFRSSSEAK---LSVEPLRCHGDKNYWNAASFTTPSSYLHFSTFQGETSADISFYFKTSAPDGVFLENRGKTD--FIKLELKSNTEVSFAFDVGNGPVELIVRSPSPLNDDQWHRVRAERNVKEASLQVDQ-LPWQLHKAPTQGHTRLELYSQLFVGAAGD-QRGFLGCIRSLRMNGMTLDLEERAKITPGVKPGCSGHCTSFGMYCQNGGKCVEKYNGYTCDCSRTAYDGPYCNKDVGGYFEEGTWLRYNFHSASTAAVVSTKETGNIPQSSASDIGLAKEELLFSFSTTKSPCILLYISSYS-QDYLAVLLKASGILQIRYNLGGTKDPYNIDISDHKNMANGQPHSINITRS--GRNVIFQLDHY----PPAVYNLPSASDTQFNGPKALFLGKVIETGTKDQDIHSYNTPGFSGCLSRVQFNLIAPLKAALRSSNNSQVFIQGE-LVESNCGASPLTIPPMTSNTDPWHSE-----SPEFPNNEGQAIKDGVNRNSAIIGGIIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESADTADAAIINNDPNFTETIDESKKEW 1316          

Query:  114 ERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            + PL +   +   + S IKS S      A  YA+L+  D          AG WS  D +  Q++QVD   RK I +IA QGR  S+++V  Y + +SD      WK +    G  + F GN N +TV   +L +P++AR+VRI P  WN+   I +R EL+GC Y      FDG S + YR     + ++T  D I  +FK+S   G+I + EG + DYIT+E+ +++L +++NLG+    +     ++  +GS+LDD+ WH V I R  +++N+TLDR         DF  L+L+  ++ GG+  F+GK   S  +NF GC+E + ++G+ I   ARRK
Sbjct:   30 DEPLVLGLPHQSFRSSSIKSGS-----YAPGYAKLNKRDE---------AGGWSPLDSDHYQWLQVDFGNRKQIRSIATQGRYSSSDWVSQYRMLYSD--TGRNWKPYHQD-GNIWAFPGNVNSDTVVRHDLQHPVIARYVRIVPLDWNEEGQIGLRTELYGCPYWADVINFDGNSGLSYRFKN--KKMKTLKDVISLKFKSSESEGVIFHGEGQEGDYITLELKKAKLVLQLNLGSNQYGSIYGHTSVT-SGSLLDDHHWHTVIIERHGRNINLTLDRHMQHFKTNGDFESLDLDFELTFGGM-PFSGKPSSSSRKNFKGCMESINYNGINITDLARRK 348          

Query:  675 QTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRV--KMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKV 1130
            +T AD I F FKTS  +G+ L   G + D+I +E     L+    +    +V    ++ I+ + S L+D+QWH V   R  K+ ++ +D++  ++ +  T     L L   + VG  G+   +RG      F+GCI  +  +G+ +  + R K+
Sbjct:  812 ETSAD-ISFYFKTSAPDGVFLENRG-KTDFIKLE-----LKSNTEVSFAFDVGNGPVELIVRSPSPLNDDQWHRVRAERNVKEASLQVDQLPWQLHKAPTQGHTRLELYSQLFVGAAGD---QRG------FLGCIRSLRMNGMTLDLEERAKI 949          

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQV----TYNTFQYFTKDISLGKDFYIGGGRAAVS---------SFQGCLRNIYINNVQVNYDP-----KNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYN---TADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDT-TTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITL------------------DYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTR--YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSK---------LGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIPDWQRTGIIVGV---------IMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTN---QPDVAGKEW 4105
            + G   +DG WH V L   +N   LTV  D+     T +  Q+ T     G  ++ GG  +  +         SFQGC++ I++++  V+            ++I    C++ID C+PN C+H   CTQ   + TCNC  TGY+G  CH S    SC   + +  G +SS    +D DGSG L P +V C+ +   + TT+ H  + +  +V   LD      P+V N   +A  + ++ +   + YCEQ ISY C  ++LL  P G         + WWVG+  +   YWGG  PGIQKC CGI+  CS +   CNCD D   Q   + D+G L+ K  LPV++V +GDT  +  E K   ++V PLRC GD  + N  +F+   S L+      E   D+ F FKT+  + V L++  K +  F ++ ++    +   F++G G +E+I    + LND+ WH VR ERN KE+ L +D+  P    + P + +T     S+L VG++     G++GC  +L +NG+  DL+       G+  GC+  CT     C N G+C E Y+GY C+C  T Y G  C ++VG  F +G+ +                        S   I   +E +   F T      LL +SS   + Y+ + +  +G + I +++G T+  Y +      ++ N Q H++   RS  G+    Q+D Y       +  L + SD + + P  +++G+     +K          GF+GC+ R+QFN I PLK          V + G  + E+NCG   +           +        + + P+ +   I  GV         I+AV+   IL  L+F  R     +G Y T EAKGA+  DTAD AI     N     D + KEW
Sbjct:  462 SSGSGLNDGQWHEVRLTAKENFAILTVDGDEASSVRTNSPLQFQT-----GSRYFFGGFYSLSNYTDHSLLQHSFQGCMQLIHVDDQLVDLHAVEQGKHGSYANISIDMCAIIDRCVPNNCEHGGRCTQTWDSMTCNCEGTGYTGATCHNSIYELSCE--AYKHLG-KSSDWYWIDPDGSGPLGPLKVFCNMTEDKVWTTLFHDLSLQTPIVAASLDK-----PVVLNLNYSASMEQISAITGSAEYCEQYISYSCRMSRLLNTPDG-------NPYTWWVGKGNEKHHYWGGSSPGIQKCACGIERNCSDSKFHCNCDAD---QRQWRKDAGFLSYKDHLPVSQVVVGDTFRSSSEAK---LSVEPLRCHGDKNYWNAASFTTPSSYLHFSTFQGETSADISFYFKTSAPDGVFLENRGKTD--FIKLELKSNTEVSFAFDVGNGPVELIVRSPSPLNDDQWHRVRAERNVKEASLQVDQ-LPWQLHKAPTQGHTRLELYSQLFVGAAGD-QRGFLGCIRSLRMNGMTLDLEERAKITPGVKPGCSGHCTSFGMYCQNGGKCVEKYNGYTCDCSRTAYDGPYCNKDVGGYFEEGTWLRYNFHSASTAAVVSTKETGNIPQSSASDIGLAKEELLFSFSTTKSPCILLYISSYS-QDYLAVLLKASGILQIRYNLGGTKDPYNIDISDHKNMANGQPHSINITRS--GRNVIFQLDHY----PPAVYNLPSASDTQFNGPKALFLGKVIETGTKDQDIHSYNTPGFSGCLSRVQFNLIAPLKAALRSSNNSQVFIQGE-LVESNCGASPLTIPPMTSNTDPWHSE-----SPEFPNNEGQAIKDGVNRNSAIIGGIIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESADTADAAIINNDPNFTETIDESKKEW 1336          

Query:  114 ERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK--VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            + PL +   +   + S IKS S      A  YA+L+  D          AG WS  D +  Q++QVD   RK I +IA QGR  S+++V  Y + +SD      WK +    G  + F GN N +TV   +L +P++AR+VRI P  WN+   I +R EL+GC Y      FDG S + YR     + ++T  D I  +FK+S   G+I + EG + DYIT+E+ +++L +++NLG+    +     ++  +GS+LDD+ WH V I R  +++N+TLDR         DF  L+L+  ++ GG+  F+GK   S  +NF GC+E + ++G+ I   ARRK
Sbjct:   50 DEPLVLGLPHQSFRSSSIKSGS-----YAPGYAKLNKRDE---------AGGWSPLDSDHYQWLQVDFGNRKQIRSIATQGRYSSSDWVSQYRMLYSD--TGRNWKPYHQD-GNIWAFPGNVNSDTVVRHDLQHPVIARYVRIVPLDWNEEGQIGLRTELYGCPYWADVINFDGNSGLSYRFKN--KKMKTLKDVISLKFKSSESEGVIFHGEGQEGDYITLELKKAKLVLQLNLGSNQYGSIYGHTSVT-SGSLLDDHHWHTVIIERHGRNINLTLDRHMQHFKTNGDFESLDLDFELTFGGM-PFSGKPSSSSRKNFKGCMESINYNGINITDLARRK 368          

Query:  675 QTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRV--KMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKV 1130
            +T AD I F FKTS  +G+ L   G + D+I +E     L+    +    +V    ++ I+ + S L+D+QWH V   R  K+ ++ +D++  ++ +  T     L L   + VG  G+   +RG      F+GCI  +  +G+ +  + R K+
Sbjct:  832 ETSAD-ISFYFKTSAPDGVFLENRG-KTDFIKLE-----LKSNTEVSFAFDVGNGPVELIVRSPSPLNDDQWHRVRAERNVKEASLQVDQLPWQLHKAPTQGHTRLELYSQLFVGAAGD---QRG------FLGCIRSLRMNGMTLDLEERAKI 969          

Query: 1466 YK*ITGYL-TVEVTL-DGVLPIAYSIPNPD--LTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQY-FTKDISLGKDFYIGGGRAAVS---------SFQGCLRNIYINNVQVNYDPKNFD-----SSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQ-----NQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN-NLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQN--PCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITL--------------DYSDQKISTL-EEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNF------SQVSKL---GFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            Y   TG L ++E+ L +G + ++ S P     + A G   +DG WHSV L   +N   V+ D+     F+  +   +  G  +Y GG     +         +F GC++ I ++   V+            S +    C++ D C PNPC+H   C Q    F C C +TGY G+ CH+S    +C   + R +G + S   T+D DGSG + PF V CD S      TIVHH+      V G      F   + Y  A    ++ L   S YCEQ I + C+ ++LL  P G         + +W+GR  +  FYWGG  PGIQ+C CGI  +C+     CNCDGD    T  + D G+L  +  LPVT V +GDT     G  +  +VGPLRC GD    NT+TF K  S+L+ P    +   D+ F FKTT  +   L++   +      + F  + +         +++G G E + V      NDN WH V+ E N K +RL +D   P + ++ P + Y    +D  L VG+++     ++GC   L +NGV  DL+    +  G+   C   C +    C N G C E YS Y C+C  T + G  C R++GA F  G+ V  ++               Y    +S L  E I   F+T      LL VSS     YI + V  +G + + + VG T Y    +   ++ + + H +   R ++  T   QVD Y + K  F        D + D P  +Y+GR        S+V K    GFTGC+  ++FNNI P++ +F       +      + E+NC 
Sbjct:  355 YSSFTGSLGSLEMALSEGQINVSISQPGMKKLVFAAGYRLNDGFWHSVSLVARENSAVVIIDEDEGAEFKVNYDFQVGTGDTYYFGGCPKPAAGSGCYSNQTAFHGCMQMINVDGQPVDLHRMQLGLFGRFSEVMFNVCAIADRCRPNPCEHGGRCYQSWDDFFCICDMTGYKGETCHKSLFKENCD--AYRVSG-KYSGNYTIDPDGSGPMKPFYVHCDISE-ERAWTIVHHDRYYATRVTGSSPDQPFLGEVNYWNATWGEVSALANGSEYCEQRIEFSCYRSRLLNTPNG-------LPYSFWMGRNNERHFYWGGSSPGIQRCGCGIDKSCADPKLFCNCDGDY---TQWKYDKGLLKFRDHLPVTRVVVGDTNRT--GSEAWFSVGPLRCYGDRNTWNTVTFMKGASLLF-PTFKPDTSIDISFYFKTTARSGTFLETSGNRCGFPLCRNFIRIELNS-----FIYDIGNGFENVTVKSPFKFNDNEWHQVKAEMNVKLARLKVDL-LPWSIRKFPLQTYLNMTYDQPLYVGTAEHKLKPFLGCLRALRMNGVTLDLEGKANETLGLRTNCTGYCEKPRLECQNGGRCVERYSHYTCDCNGTGFEGPFCTRDIGAYFEAGTWVRHSILSAAMVAAQEFANVAYLPLFVSNLTREEISFSFRTTTSPAVLLYVSSFS-SDYIAVLVRPDGTLQLNYKVGITPYVYQLNK-RNMTDGRPHRVNITRENL--TLYTQVDFYPLEKNQFYLW----EDRKFDTPKALYLGRVVEIGIIDSEVQKFNTPGFTGCLADVRFNNITPVRDIFRPSNSAGIITVKGSLVESNCA 1154          

Query:  267 AWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSN-EFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAA 1142
             WS    +   ++Q+DL ++  I  +A QG   S  ++V  Y + +  GD P+ WK F    G  + FFGN N + V    L YP+ AR+VR  P  WN    I +R  LFGC Y+     FDG     Y+L   G+  +T  D I F FKT   NG++++AEG Q DYIT+E+ ++RL  +M+LG    + P     ++  GS+LDD  WH V I R  +DLN+TLD   +      DF  L+L+  I   G+     ++ +S  QNF GC+E ++F+G+ I   ARRK +  A
Sbjct:   15 GWSPAPGDKLPWLQIDLKQKYKIMGVATQGTHNSYYDWVTKYVLLY--GDRPDSWKPFFQQ-GTNWTFFGNVNSSGVKEHRLYYPVKARYVRFVPVAWNPKGKIGLRVGLFGCPYRHDVLSFDGDDLFSYKLK--GKISRTLNDSISFNFKTLEKNGMLMHAEGSQGDYITLELQKARLIFQMSLGNS-PIHPVDSHTVVKLGSLLDDQHWHSVYIERQGRDLNITLDGETIRVKCKGDFDQLDLDTEIFFAGI--VYQEKSLSHKQNFRGCLENILFNGINIADLARRKKSSIA 301          

Query: 2558 KSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTT-----FNFDSELIVGSS-QSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGI-------SIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREV 3238
            KSSI  VG +R +   +    +TFS  ++ L +P + A  +  + F F+T  +  ++L S    +    E+ + EG  + V+ +     +++      LND FWH V        + +IIDE+     + + D    T     F    +   GS   S    + GC   + V+G   DL       +G              +C  NPC + G CY+ +  ++C C +T Y+G  C + +
Sbjct:  297 KSSIAFVGKVRFSCIEMPYVPVTFSGINNYLLVPGVPASPKMMVSFKFRTWDTVGLLLYSSFTGSLGSLEMALSEG-QINVSISQPGMKKLVFAAGYRLNDGFWHSVSLVARENSAVVIIDEDEGAEFKVNYDFQVGTGDTYYFGGCPKPAAGSGCYSNQTAFHGCMQMINVDGQPVDLHRMQLGLFGRFSEVMFNVCAIADRCRPNPCEHGGRCYQSWDDFFCICDMTGYKGETCHKSL 535          

Query: 1466 YK*ITGYL-TVEVTL-DGVLPIAYSIPNPD--LTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQY-FTKDISLGKDFYIGGGRAAVS---------SFQGCLRNIYINNVQVNYDPKNFD-----SSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQ-----NQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN-NLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQN--PCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITL--------------DYSDQKISTL-EEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNF------SQVSKL---GFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            Y   TG L ++E+ L +G + ++ S P     + A G   +DG WHSV L   +N   V+ D+     F+  +   +  G  +Y GG     +         +F GC++ I ++   V+            S +    C++ D C PNPC+H   C Q    F C C +TGY G+ CH+S    +C   + R +G + S   T+D DGSG + PF V CD S      TIVHH+      V G      F   + Y  A    ++ L   S YCEQ I + C+ ++LL  P G         + +W+GR  +  FYWGG  PGIQ+C CGI  +C+     CNCDGD    T  + D G+L  +  LPVT V +GDT     G  +  +VGPLRC GD    NT+TF K  S+L+ P    +   D+ F FKTT  +   L++   +      + F  + +         +++G G E + V      NDN WH V+ E N K +RL +D   P + ++ P + Y    +D  L VG+++     ++GC   L +NGV  DL+    +  G+   C   C +    C N G C E YS Y C+C  T + G  C R++GA F  G+ V  ++               Y    +S L  E I   F+T      LL VSS     YI + V  +G + + + VG T Y    +   ++ + + H +   R ++  T   QVD Y + K  F        D + D P  +Y+GR        S+V K    GFTGC+  ++FNNI P++ +F       +      + E+NC 
Sbjct:  371 YSSFTGSLGSLEMALSEGQINVSISQPGMKKLVFAAGYRLNDGFWHSVSLVARENSAVVIIDEDEGAEFKVNYDFQVGTGDTYYFGGCPKPAAGSGCYSNQTAFHGCMQMINVDGQPVDLHRMQLGLFGRFSEVMFNVCAIADRCRPNPCEHGGRCYQSWDDFFCICDMTGYKGETCHKSLFKENCD--AYRVSG-KYSGNYTIDPDGSGPMKPFYVHCDISE-ERAWTIVHHDRYYATRVTGSSPDQPFLGEVNYWNATWGEVSALANGSEYCEQRIEFSCYRSRLLNTPNG-------LPYSFWMGRNNERHFYWGGSSPGIQRCGCGIDKSCADPKLFCNCDGDY---TQWKYDKGLLKFRDHLPVTRVVVGDTNRT--GSEAWFSVGPLRCYGDRNTWNTVTFMKGASLLF-PTFKPDTSIDISFYFKTTARSGTFLETSGNRCGFPLCRNFIRIELNS-----FIYDIGNGFENVTVKSPFKFNDNEWHQVKAEMNVKLARLKVDL-LPWSIRKFPLQTYLNMTYDQPLYVGTAEHKLKPFLGCLRALRMNGVTLDLEGKANETLGLRTNCTGYCEKPRLECQNGGRCVERYSHYTCDCNGTGFEGPFCTRDIGAYFEAGTWVRHSILSAAMVAAQEFANVAYLPLFVSNLTREEISFSFRTTTSPAVLLYVSSFS-SDYIAVLVRPDGTLQLNYKVGITPYVYQLNK-RNMTDGRPHRVNITRENL--TLYTQVDFYPLEKNQFYLW----EDRKFDTPKALYLGRVVEIGIIDSEVQKFNTPGFTGCLADVRFNNITPVRDIFRPSNSAGIITVKGSLVESNCA 1170          

Query:  261 AGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSN-EFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAA 1142
            A  WS    +   ++Q+DL ++  I  +A QG   S  ++V  Y + +  GD P+ WK F    G  + FFGN N + V    L YP+ AR+VR  P  WN    I +R  LFGC Y+     FDG     Y+L   G+  +T  D I F FKT   NG++++AEG Q DYIT+E+ ++RL  +M+LG    + P     ++  GS+LDD  WH V I R  +DLN+TLD   +      DF  L+L+  I   G+     ++ +S  QNF GC+E ++F+G+ I   ARRK +  A
Sbjct:   29 ASGWSPAPGDKLPWLQIDLKQKYKIMGVATQGTHNSYYDWVTKYVLLY--GDRPDSWKPFFQQ-GTNWTFFGNVNSSGVKEHRLYYPVKARYVRFVPVAWNPKGKIGLRVGLFGCPYRHDVLSFDGDDLFSYKLK--GKISRTLNDSISFNFKTLEKNGMLMHAEGSQGDYITLELQKARLIFQMSLG-NSPIHPVDSHTVVKLGSLLDDQHWHSVYIERQGRDLNITLDGETIRVKCKGDFDQLDLDTEIFFAGI--VYQEKSLSHKQNFRGCLENILFNGINIADLARRKKSSIA 317          

Query: 2558 KSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTT-----FNFDSELIVGSS-QSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGI-------SIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREV 3238
            KSSI  VG +R +   +    +TFS  ++ L +P + A  +  + F F+T  +  ++L S    +    E+ + EG  + V+ +     +++      LND FWH V        + +IIDE+     + + D    T     F    +   GS   S    + GC   + V+G   DL       +G              +C  NPC + G CY+ +  ++C C +T Y+G  C + +
Sbjct:  313 KSSIAFVGKVRFSCIEMPYVPVTFSGINNYLLVPGVPASPKMMVSFKFRTWDTVGLLLYSSFTGSLGSLEMALSEG-QINVSISQPGMKKLVFAAGYRLNDGFWHSVSLVARENSAVVIIDEDEGAEFKVNYDFQVGTGDTYYFGGCPKPAAGSGCYSNQTAFHGCMQMINVDGQPVDLHRMQLGLFGRFSEVMFNVCAIADRCRPNPCEHGGRCYQSWDDFFCICDMTGYKGETCHKSL 551          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTK-DISLGKDFYIGGG---------RAAVSSFQGCLRNIYINN-----VQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD----------------YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVD------------DYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            G   +DG+WHSV +   +N++T+  D    +     ++  I  GK +Y GG             + +FQGC+R I+I+N     + V        S +    CS+ D C+PN C+H   C Q   TF CNCS TGY+G  CH S    SC     R     ++    VD DGSG L P QV C+ +   I  T V HNN +   V+G      + + L Y     + L  L+  S YCEQ + Y C  ++LL  P G         F WW+GR  +   YWGG +PG+Q+C CG++ +C  +   CNCD D+        D+G+ + K  LPVT++ + DT        +   +GPLRC GD  F N ++FS   S L+ P    E   D+ F FKTT  + V L+++  ++  FF  R+       VTF +  G   IE++V +   LNDN WH +R E N KE+ L +D N P + +E  +  +     +S+L VG + S   G++GC  +L++NG   DL+       G+  GC   C+   + C N G+C E ++GY C+C  +PY G  C +E+ A F  G++V                     Y+D  ++  +E I + F T      LL ++ +  + ++ I ++ NG + + + +      V      +L N + H +K  R   G   +IQ+D            ++R ++   +  ++   D  LD           ++ + LGF GC+  +Q+N+I PLK       +  V V  T + E++CG
Sbjct:  442 GSGLNDGLWHSVSINARRNRVTLTLDNDAASPAPDTSRIQIYSGKSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKDLISVQQGSLGSFSDLHIDLCSIKDRCLPNYCEHGGHCDQTWTTFYCNCSGTGYTGATCHDSIYEQSCEVYRHR---GHTAGFFYVDSDGSGPLGPLQVYCNITEDKIWMT-VQHNNTELTRVQGSSPENPYSMTLNYG-GSMEQLEALIDGSEYCEQEVIYHCRRSRLLNTPDGA-------PFTWWIGRSTERHPYWGGAVPGVQQCGCGLEESCLDSRHFCNCDADI---DEWANDTGLFSFKDHLPVTQIIIMDTNRT--NSEAAWRIGPLRCYGDRHFWNAVSFSTEASYLHFPTFHTEFSADISFFFKTTALSGVFLENLGIKD--FF--RLEMSSPSEVTFAIDVGNGPIELLVQSPYPLNDNQWHYIRAETNLKETSLQVD-NLPQSMREASEGGHFRLQLNSQLFVGGTSSRQKGFLGCIRSLLLNGHKVDLEERAKVTSGVRPGCPGHCSSYGSNCHNGGKCVEKHTGYSCDCTNSPYEGPFCRKEISALFDSGTSVTYMFQEPYPVTKNTSLSSSAIYTD--LAPFKETIMLSFMTTQAPTLLLYLNFSS-QNFLAILLSRNGSLQVRYRLSKDESHVFNMDTENLANRRVHQVKISRD--GPELSIQMDQQLFSYSFSPEVEFRTLRSLVLGKVTETLD--LDP--------EVARANTLGFVGCLSSVQYNHIAPLKAALRHASIAPVTVQKT-LTESSCG 1199          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQP---FLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK--VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNL-GAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGN 1151
            G G WS  D N QQ++Q+DL  R  ITA+A QGR GS+++V  Y + FS  D    W+    PY Q    + F GN N ++V    L + + AR VR  P  WN    I +R E +GC Y+   A FDG+S ++YR +Q  + + T  D I  +FK+   +G++ + EG + D+IT+E+ + RL + +NL  +K  ++  S   ++  GS+LDD  WH V + R  K  N T+D          D   L+++  +S GG+     K G  + +NF GCIE + ++G+ II  A+R+ +   +GN
Sbjct:   63 GTGGWSPADSNAQQWLQIDLQNRVEITAVATQGRYGSSDWVTSYRLMFS--DTGHNWQ----PYNQEDSIWTFVGNMNSDSVVHHKLLHSVRARFVRFVPLEWNPNGKIGMRVEAYGCSYRSDVADFDGRSSLLYRFNQ--KTMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLALYLNLDDSKARLS--STVPLVILGSLLDDQHWHSVLLERVGKQANFTVDMNTQHFRTKGDTDSLDIDYELSFGGI-PVPSKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYSGN 355          

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQV----TYNTFQYFTKDISLGKDFYIGG---------GRAAVSSFQGCLRNIYINNVQVNY------DPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFID------------------GSAVEITLDYSDQKISTL-EEYIEIGFKTKDKQGTLLQVSS--NDFKKYIIIKVNNNGGITIEFDVGFTR--YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGR---------NFSQVSKLGFTGCIYRLQFNNIFPLK-MLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIP-----------DWQRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTN---QPDVAGKEW 4105
            + G   +DG WH V     +N   LT+  D+     T +  Q     +  G+ ++ GG           A   SFQGC++ I +++  VN        P +F +++    C++ID C+PN C+H   C+Q   +F C C  TGYSG  CH S    SC   + +  G Q+S    +D DGSG L P +V C+ +   + T IV H+ +    V G+ +P  + +  +  +A  D ++ +   + YCEQ +SY C  ++LL  P G         + WWVG+  +  +YWGG  PGIQKC CGI+  C+     CNCD D       + D+G L+ K  LPV++V +GDT    +G  + ++VGPLRC GD  + N  +F    S L+      E   D+ F FKT +   V L+++   N  F ++ ++    +  +F++G G +EI+    + LND+ WH V  ERN K++ L +D   P   ++ P   +T     S+L VG +     G++GC  +L +NGV  DL+       G   GC+  CT     C N G+C E Y GY C+C  T Y G  C ++VGA F +                  GS  E + D        L +E I   F T      LL VSS   DF   + + V   G + I +++G TR  + +  D+  ++ N Q H++   R +  +T  +++D Y  +       L ++SD   + P  +++G+            + +  GFTGC+ R+QFN+I PLK  L       +V + G  + E+NCG   +           +      + + D P              R   I+G ++AV+   IL  L+F  R     +G Y T EAKGA+  ++AD AI     N     D + KEW
Sbjct:  448 SSGSGLNDGQWHEVRFLAKENFAVLTIDGDEASAVRTNSPLQ-----VKTGEKYFFGGFLNHMNNASYSALQPSFQGCMQLIQVDDQLVNLYEVAHRKPGSF-ANVTIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCE--AYKHLG-QTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWT-IVSHDLQMQTTVVGY-NPEKYSVTQLIYSASMDQISAITSSAEYCEQYVSYFCRMSRLLNTPDG-------SPYTWWVGKANEKHYYWGGSEPGIQKCACGIERNCTDPKYYCNCDADY---KQWRKDAGFLSYKDHLPVSQVVVGDTDR--QGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLIPRGVFLENLG--NTDFIKLELKSATEVSFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVDR-LPQQIRKAPTEGHTRLELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFKSGCSGHCTSYGANCENGGKCIEKYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPAVTARDTGSRAENSADQQQHLAPDLAQEQIHFSFSTTKAPCILLYVSSLTTDF---LAVLVKPTGNLQIRYNLGGTREPFNIDVDH-RNMANGQPHSVNITRHE--RTIILKLDHYPAVGYH----LPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNHIAPLKAALRQTNASAHVHIQGE-LVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTETIDESKKEW 1330          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            GAG WS  D +  Q++QVD   RK I+AIA QGR  S+++V  Y + +S  D    WK +    G  + F GN N ++V   +L + +VAR+VR+ P  WN    I +R E++GC Y      FDG   + YR     + ++T  D I  +FKTS   G++L+ EG Q DYIT+E+ +++L + +NLG+   + P      + +GS+LDD+ WH V I R  + +N+TLDR         +F +L+L+  I+ GG+  F+GK   S  +NF GC+E + ++G+ I   ARRK
Sbjct:   70 GAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYS--DTGRNWKPYHQD-GNIWAFPGNVNSDSVVRHDLQHAVVARYVRVVPLDWNGEGHIGLRAEVYGCAYWADVINFDGHGVLPYRFRN--KKMKTLKDVIALKFKTSESEGVLLHGEGQQGDYITLELKKAKLVLSLNLGSN-QLGPIYGHTSVTSGSLLDDHHWHSVLIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGI-PFSGKPSSSNRKNFKGCMESINYNGVNITDLARRK 354          

Query:  480 NDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQ--FDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAE-GDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQ-NFIGCIEEMVFD----GLYIIRDARRKVNMAAN 1145
            N N V +T+L     AR  ++ P     +       F C+ +P+T    F+  S     L+ PGR  Q     + F+F+T N +GL+L++   D    + I++  S++ V +N     N   ++    + +GS L+D QWH+V     E    +T+D  +     T+  + +        GG  N       S +Q +F GC++ +  D     LY +  A RK    AN
Sbjct:  341 NYNGVNITDL-----ARRKKLEPSNMGNLS------FSCV-EPYTVPVFFNATSY----LEVPGRLNQDLF-SVSFQFRTWNPSGLLLFSHFADNLGNVEIDLVESKVGVHIN-----NTQTKTSQIDISSGSGLNDGQWHEVRFLAKENFAVLTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNHMNNASYSALQPSFQGCMQLIQVDDQLVNLYEV--AHRKPGSFAN 546          

Query:  675 QTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRV--KMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKV 1130
            +T AD I F FKT    G+ L   G+  D+I +E     L+    +    +V    ++ ++ + S L+D+QWH V   R  K  ++ +DR+  ++ +  T     L L   + VGG G           Q F+GCI  +  +G+ +  + R KV
Sbjct:  818 ETSAD-ISFYFKTLIPRGVFLENLGNT-DFIKLE-----LKSATEVSFSFDVGNGPVEIVVRSPSPLNDDQWHRVTAERNVKQASLQVDRLPQQIRKAPTEGHTRLELYSQLFVGGAGG---------QQGFLGCIRSLRMNGVTLDLEERAKV 955          

Query: 1547 DLTADGRSFSDGMWHSVELYLTKNKLTVVAD-QVTYNTFQYFTKDISLGKDFYIGGG---------RAAVSSFQGCLRNIYINNVQVNYDP------KNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAV--EITLDYSDQKISTLE------------EYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVG-FTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKP-TYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNC 3802
            D+TA G    DG WHSV L   +N L+VV D  ++  +     + ++ G  FY GG          ++ +  FQGC+R I INN  V+          NF S ++  +C + D C+PN C+H   C+Q   TF CNC+ TGY+G  CH S    SC   + +  G  +S    +D DGSG L PF + C+ +      T++ HN    + V       +      Y TA  + L   + R+ +C+Q + Y C  ++L+    G   +       WWVGR  +   YWGG +P  QKC CG++G C      CNCD D+        D+G L+ K  LPVT++ + DT        +   +GPL C GD  F N  +F+   S L+ P    E   D+ F FKTT  + V L+++   +  F  + +R   T+  +F++G G  E+      + NDN WH VR ERN KE+ L +DE  P   Q  P   +     +S+L VG + +   G++GC  +L +NG+  DL+   T   G+  GC   C      C + G+C E  SG++C+C  + Y G  C +E+ A F  GS+V      +YS  K S+              E I+  F+T      LL +SS  +K+Y+ I +  NG + I + +  +   +V +  +  + + Q H +K  R +      I  +  R    S  +  SA     L +   Y  V +  +  +  GFTGC+  +QF++I PLK      P   V V+G  + E++C
Sbjct:  443 DITA-GAGLGDGQWHSVSLSAKRNHLSVVVDGHISPASPWLGPEQVNSGGVFYFGGCPDKGFGSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNF-SDLQIDSCGISDRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCE--AYKHQG-NASGFYYIDSDGSGPLQPFLLYCNMT--ETAWTVMQHNGSDLMRVRNTHSENAHTGVFEY-TASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGSPRS-------WWVGRTNETQTYWGGSLPVHQKCTCGLEGNCIDAQYHCNCDADL---NEWTNDTGFLSYKEHLPVTKIVITDTGRP--HSEAAYKLGPLLCRGDRPFWNAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITD--FIRIELRSPTTVTFSFDVGNGPFELSVHSPTHFNDNQWHHVRVERNMKEASLRVDELPPKI-QAAPTDGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMALDLEERATVTPGVQPGCRGHCGSYGKLCRHGGKCREKPSGFFCDCSSSAYAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDMKLSREMIKFSFRTTRAPSLLLHMSSF-YKEYLSIIIAKNGSLQIRYKLNKYHEPDVISFDLKSMADGQLHHIKINREEGMVFVEIDENTRRQTYLSSGTEFSAVKSLVLGRMLEYSDVDQETALAAAHGFTGCLSAVQFSHIAPLKAALQPGPPAPVTVTGH-VTESSC 1204          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISV-MQNFIGCIEEMVFDGLYII 1109
            GAG WS    N  Q++Q+DL ER  +T++A QG  GS+ +V  Y + FSD      WK +R      + F GN+N ++V    L   I AR +R  P  WN    I +R E+FGC Y+      DGKS ++YR DQ   ++    D I  +FKT   +G++L+  G   D+IT+E+ R +L + +N G     +  ++ N L  GS+LDD  WH V I+R  K +N T+D  +   +   +F +L+L+  IS GG+   A  + +S+  ++F GC+E + ++G+ +I
Sbjct:   68 GAGGWSPLVSNKYQWLQIDLGERMEVTSVATQGGYGSSNWVTSYLLMFSDSG--RNWKQYRQE-DSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSVVIDLDGKSSLLYRFDQ--NSLSPIRDIISLKFKTMESDGILLHRAGPAGDHITLELRRGKLFLLINSGDARLTSSSTLIN-LTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRRHFHAQGEFNYLDLDYEISFGGIS--APAKSVSLPYKHFHGCLENLFYNGVDVI 346          

Query: 1547 DLTADGRSFSDGMWHSVELYLTKNKLTVVAD-QVTYNTFQYFTKDISLGKDFYIGGG---------RAAVSSFQGCLRNIYINNVQVNYDP------KNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAV--EITLDYSDQKISTLE------------EYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVG-FTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKP-TYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNC 3802
            D+TA G    DG WHSV L   +N L+VV D  ++  +     + ++ G  FY GG          ++ +  FQGC+R I INN  V+          NF S ++  +C + D C+PN C+H   C+Q   TF CNC+ TGY+G  CH S    SC   + +  G  +S    +D DGSG L PF + C+ +      T++ HN    + V       +      Y TA  + L   + R+ +C+Q + Y C  ++L+    G   +       WWVGR  +   YWGG +P  QKC CG++G C      CNCD D+        D+G L+ K  LPVT++ + DT        +   +GPL C GD  F N  +F+   S L+ P    E   D+ F FKTT  + V L+++   +  F  + +R   T+  +F++G G  E+      + NDN WH VR ERN KE+ L +DE  P   Q  P   +     +S+L VG + +   G++GC  +L +NG+  DL+   T   G+  GC   C      C + G+C E  SG++C+C  + Y G  C +E+ A F  GS+V      +YS  K S+              E I+  F+T      LL +SS  +K+Y+ I +  NG + I + +  +   +V +  +  + + Q H +K  R +      I  +  R    S  +  SA     L +   Y  V +  +  +  GFTGC+  +QF++I PLK      P   V V+G  + E++C
Sbjct:  443 DITA-GAGLGDGQWHSVSLSAKRNHLSVVVDGHISPASPWLGPEQVNSGGVFYFGGCPDKGFGSKCKSPLGGFQGCMRLISINNKMVDLIAVQQGALGNF-SDLQIDSCGISDRCLPNSCEHGGECSQSWSTFHCNCTNTGYTGATCHSSVYEQSCE--AYKHQG-NASGFYYIDSDGSGPLQPFLLYCNMT--ETAWTVMQHNGSDLMRVRNTHSENAHTGVFEY-TASMEQLQAAINRAEHCQQELVYYCKKSRLVNQQDGSPRS-------WWVGRTNETQTYWGGSLPVHQKCTCGLEGNCIDAQYHCNCDADL---NEWTNDTGFLSYKEHLPVTKIVITDTGRP--HSEAAYKLGPLLCRGDRPFWNAASFNTEASYLHFPTFHGELSADVSFFFKTTALSGVFLENLGITD--FIRIELRSPTTVTFSFDVGNGPFELSVHSPTHFNDNQWHHVRVERNMKEASLRVDELPPKI-QAAPTDGHVLLQLNSQLFVGGTATRQRGFLGCIRSLQLNGMALDLEERATVTPGVQPGCRGHCGSYGKLCRHGGKCREKPSGFFCDCSSSAYAGPFCSKEISAYFGSGSSVIYNFQENYSLSKNSSFHAASFHGDMKLSREMIKFSFRTTRAPSLLLHMSSF-YKEYLSIIIAKNGDLQIRYKLNKYHEPDVISFDLKSMADGQLHHIKINREEGMVFVEIDENTRRQTYLSSGTEFSAVKSLVLGRMLEYSDVDQETALAAAHGFTGCLSAVQFSHIAPLKAALQPGPPAPVTVTGH-VTESSC 1204          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISV-MQNFIGCIEEMVFDGLYII 1109
            GAG WS    N  Q++Q+DL ER  +T++A QG  GS+ +V  Y + FSD      WK +R      + F GN+N ++V    L   I AR +R  P  WN    I +R E+FGC Y+      DGKS ++YR DQ   ++    D I  +FKT   +G++L+  G   D+IT+E+ R +L + +N G     +  ++ N L  GS+LDD  WH V I+R  K +N T+D  +   +   +F +L+L+  IS GG+   A  + +S+  ++F GC+E + ++G+ +I
Sbjct:   68 GAGGWSPLVSNKYQWLQIDLGERMEVTSVATQGGYGSSNWVTSYLLMFSDSG--RNWKQYRQE-DSIWGFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEVFGCAYRSVVIDLDGKSSLLYRFDQ--NSLSPIRDIISLKFKTMESDGILLHRAGPAGDHITLELRRGKLFLLINSGDARLTSSSTLIN-LTLGSLLDDQHWHSVLIQRLGKQVNFTVDEHRRHFHAQGEFNYLDLDYEISFGGIS--APAKSVSLPYKHFHGCLENLFYNGVDVI 346          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISL-----GKDFYIGGG---------RAAVSSFQGCLRNIYINN-----VQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTT-TKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD--YSDQKISTL------------EEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDAR---LDKPTYVY-VGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNC 3802
            G   +DGMWHSV +   +N++T+  D    N       D S      G  +Y GG             + +FQGC+R I+I+N     + V        S +    CS+ D C+PN C+H   C Q    F CNCS TGY+G  CH S    SC     R    ++++   VD DGSG L P QV C+ +   I  T V HNN     V+G      + + L Y     + L  L+  S +CEQ ++Y C  ++LL  P G         F WW+GR  +   YWGG +PG+Q+C CG++ +C      CNCD D         D+G L+ K  LPVT++ + DT  +K E    I   GPLRC GD  F N ++FS   S L+ P    E   D+ F FKTT  + V L+ +  ++     +R+       V F +  G   I+++V +   LNDN WH +R ERN KE+ L +D N P + +E  +  +  F  +S+L VG   S   G+ GC  +L +NG   DL+       G+  GC   C+     C N G+C E + GY C+C  +PY G  C +E+ A F   ++V       YS  K + L            +E I + F T      LL ++ +  + ++ I ++ NG + I + +      V T    +L N + H +K  R   G   +IQ+D  ++   +F S+ S    AR   L K T    +    ++ + LGF GC+  +Q+N+I PLK       +  V V  T + E++C
Sbjct:  442 GSGLNDGMWHSVSISARRNRVTLTLD----NDAASLPPDTSWLQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKDLISVQQGSLGSFSDLHIDLCSIKDRCLPNYCEHGGQCAQTWTNFYCNCSDTGYTGATCHDSIYEQSCEVYRHR---GKTAEFFYVDSDGSGPLGPLQVFCNITEDKIWMT-VQHNNTGLTWVQGSNPEKPYAMTLNYG-GSLEQLEALIDGSEHCEQEVTYYCKRSRLLNTPDG-------VPFTWWIGRSNEKHPYWGGSLPGVQQCGCGLEESCLDIRHFCNCDADT---DEWTNDTGYLSFKDHLPVTQIIITDTNRSKSEAAWRI---GPLRCYGDRHFWNAVSFSTEASFLHFPTFRVEFSADIFFFFKTTALSGVFLEILGIKD----FLRLEMSSPSEVIFAIDVGNGPIDLLVQSPYPLNDNQWHYIRAERNLKETSLQVD-NLPQSMREASEEGHFQFQLNSQLFVGGKSSRQKGFFGCIRSLHLNGQNIDLEERAKVTSGVRPGCPGHCSSYGRNCQNGGKCVEKHIGYSCDCTNSPYEGPFCQKEISALFDSDTSVTYMFQEPYSVTKNTNLSSSAIYTDTAPSKEIIMLSFMTAQAPTLLLYLNFSS-QNFLAILLSWNGSLQIHYQLSKEESHVFTINTENLANRRVHQVKMSRD--GPELSIQMDQ-QLFSYTF-SLESEFQRARSLVLGKVTETLGLDPEVARANTLGFVGCLSSVQYNHITPLKAALRHASISPVTVQRT-LTESSC 1198          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK--VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNL-GAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGN 1151
            G G WS  D N QQ++Q+DL  R  ITA+A QGR GS+++V  Y + FS  D    W+ +    G  + F GN N N+V    L   + AR VR  P  WN    I +R E++GC Y+   A FDG S ++YR +Q  + + T  D I  +FK+   +G++ + EG + D+IT+E+   RL + +NL  +K  V+  S   +   GS+LDD  WH V + R  K  N T+D+         +   L+++  +S GG+     K G  + +NF GCIE + ++G+ II  A+R+ +   +GN
Sbjct:   63 GTGGWSPADSNAQQWLQMDLGNRVEITAVATQGRYGSSDWVTSYRLMFS--DTGHNWQQYTQE-GSIWRFVGNMNANSVVHHKLLNSVRARFVRFVPLEWNPNGKIGMRVEVYGCSYRSDVADFDGWSSLLYRFNQ--KTMSTLKDVISLKFKSIQRDGVLFHGEGQRGDHITLELQNGRLALYLNLDDSKAQVS--STAPLATLGSLLDDQHWHSVLLERVGKQANFTVDKNTQHFQTKGETDALDIDYELSFGGI-PVPSKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYSGN 355          

Query: 1571 FSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYD-PKNF--------DSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN-NLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKS-AITDPYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            F+DG WHS  + + KN+L +  DQ    T +  +  ++ G  +YI GG+   + F GC+R I ++    NY  P+++           +    C MID C PNPC+H+  C Q+ R F C+C  TGY+G VCH S NP SC  +      +Q    + +D+DGSG L PF V C+F       T + H+ E    V+G  +PGSF   ++Y+ A++  +  L+ RS  C Q +SY C +++L   P   G  R    F WW+ R  QP+ YW G +PG +KC+CGI G C   +  CNCD +         D G + +K  LPV  V+ GDT T ++ K     +GPLRC GD LF N +TF   D+ + LPP    +  D+   F+TT  N+VI  +    +  + ++ +  G  L+  +  G G   + V  + +LNDN WH V  ERNRKE+RL++D +     +E P  P    +  S+L++G++  + DGYVGC   L++NG + DLK  +    YGIS GC  +C  NPCLN G C E Y GY C+C  + ++G +C  E+G +    S +    + S +  ST+ E I +GF T   +G LL  SSN   +Y+ I+++N+G +   FD GF R E+           Q+H +   R + G T  ++VD+Y  ++ +F   + A++DA+ +   Y+Y+G+N S     GF GC+ R+QF++I+PLK++F   P  NV+  GT + E+ CG
Sbjct:  453 FNDGKWHSFVISIEKNRLILNIDQRPMTTTK--SMQVATGAQYYIAGGKDK-NGFVGCMRLISVDG---NYKLPQDWVKGEEVCCGDDVVVDACQMIDRCNPNPCQHKGLCHQNSREFFCDCGHTGYAGAVCHTSNNPLSCLALK-NVQHVQQRVNLNLDVDGSGPLEPFPVTCEFYSDGRVITTLSHSQEHTTTVDGFQEPGSFEQSIMYD-ANQLQIEALLNRSHSCWQRLSYSCRSSRLFNSPSEAGNFR---PFSWWISRHNQPMDYWAGALPGSRKCECGILGKCHDPTKWCNCDSN---SLEWMEDGGDIREKEYLPVRAVKFGDTGTPLDEKMGRYTLGPLRCEGDDLFSNVVTFRIADASINLPPFDMGHSGDIYLEFRTTQENSVIFHATGPTD--YIKLSLNGGNKLQFQYQAGSGPLGVNVGTSYHLNDNNWHTVSVERNRKEARLVVDGSIKAEVREPPG-PVRALHLTSDLVIGATTEYRDGYVGCIRALLLNGKMVDLKEYSKRGLYGISTGCVGRCESNPCLNNGTCIERYDGYSCDCRWSAFKGPICADEIGVNLRSSSIIRYEFEGSFR--STIAENIRVGFTTTIPKGFLLGFSSNLTGEYLTIQISNSGHLRCVFDFGFERQEIIFPK-KHFGLGQYHDMHFMRKNGGSTVVLKVDNYEPVEYNF--DIKASADAQFNNIQYMYIGKNESMTD--GFVGCVSRVQFDDIYPLKLMFQQNPPKNVKSLGTQLTEDFCG 1184          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIR 1112
            G  AW+  +     F+ +DL + +++  IA  GR  ++EFV +Y V++SD    E W+ + +P  +P +F GNS+ N++       PI+A+ VRI P RW+  IS+R EL+GC Y      F+G   V Y L +    I +  + I+FRFKT+  NG+++Y+ G Q DY  +++  +++ + ++LG++V  +       L  GS+LDDN WHDV I R ++D+  ++DRV +   +  +F  LNLNR + +GG+ N   + G+ V QNF GC+E + F+    IR
Sbjct:   75 GNAAWTPVENTYNHFLTLDLGDPRMVRKIATMGRMHTDEFVTEYIVQYSDDG--EFWRSYVNPTSEPQMFKGNSDGNSIHYNVFEVPIIAQWVRINPTRWHDRISMRVELYGCDYISENLYFNGTGLVRYDLRR--EPITSTKESIRFRFKTAFANGVMMYSRGTQGDYYALQLKDNKMVLNLDLGSRVMTS-------LSVGSLLDDNVWHDVVISRNQRDIIFSVDRVIVRGRIQGEFTRLNLNRELYLGGVPNV--QEGLIVQQNFSGCLENIYFNSTNFIR 346          

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQV----TYNTFQYFTKDISLGKDFYIGG---------GRAAVSSFQGCLRNIYINNVQVNY------DPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDG------------------SAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSS--NDFKKYIIIKVNNNGGITIEFDVGFTR--YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGR---------NFSQVSKLGFTGCIYRLQFNNIFPLK-MLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIP-----------DWQRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTN---QPDVAGKEW 4105
            + G   +DG WH V     +N   LT+  D+     T +  Q     +  G+ ++ GG               SFQGC++ I +++  VN        P +F +++    C++ID C+PN C+H   C+Q   +F C C  TGYSG  CH S    SC   + +  G Q+S    +D DGSG L P +V C+ +   + T IV H+ +    V G+ +P  + +  +  +A  D ++ +   + YCEQ +SY C  ++LL  P G         + WWVG+  +  +YWGG  PGIQKC CGI+  C+     CNCD D       + D+G L+ K  LPV++V +GDT    +G  + ++VGPLRC GD  + N  +F    S L+      E   D+ F FKT     V L+++ K++  F ++ ++    +  +F++G G +EI+      LND+ WH V  ERN K++ L +D   P   ++ P   +T     S+L VG +     G++GC  +L +NGV  DL+       G   GC+  CT     C N G+C E Y GY C+C  T Y G  C ++VGA F +G                  S V+   D  +      +E I   F T      LL +SS   DF   + + V   G + I +++G TR  Y +  D+  ++ N Q H++   R +  +T  +++D Y  +       L ++SD   + P  +++G+            + +  GFTGC+ R+QFN I PLK  L       +V + G  + E+NCG   +           +      + + D P              R   I+G ++AV+   IL  L+F  R     +G Y T EAKGA+  ++AD AI     N     D + KEW
Sbjct:  448 SSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQ-----VKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSF-ANVSIDMCAIIDRCVPNHCEHGGKCSQTWDSFKCTCDETGYSGATCHNSIYEPSCE--AYKHLG-QTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWT-IVSHDLQMQTPVVGY-NPEKYSVTQLVYSASMDQISAITDSAEYCEQYVSYFCKMSRLLNTPDG-------SPYTWWVGKANEKHYYWGGSGPGIQKCACGIERNCTDPKYYCNCDADY---KQWRKDAGFLSYKDHLPVSQVVVGDTDR--QGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKED--FIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRVTAERNVKQASLQVDR-LPQQIRKAPTEGHTRLELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVDNAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDF---LAVLVKPTGSLQIRYNLGGTREPYNIDVDH-RNMANGQPHSVNITRHE--KTIFLKLDHYPSVSYH----LPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGE-LVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTETIDESKKEW 1329          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIEGLSSISFKVTFRTFAVNGML-FYHVVDLMFTQFISLSINK 1475
            GAG WS  D +  Q++QVD   RK I+AIA QGR  S+++V  Y + +S  D    WK +    G  + F GN N + V    L +PI+AR+VRI P  WN    I +R E++GC Y      FDG   + YR     + ++T  D I   FKTS   G+IL+ EG Q DYIT+E+ +++L + +NLG+   + P      +  GS+LDD+ WH V I R  + +N+TLDR         +F +L+L+  I+ GG+  F+GK   S  +NF GC+E + ++G+ I   ARRK    +N                                    VGN+   C  P  +   + F +     + G++  + L S+SF+  FRT+  NG+L F H  D +    I L+ +K
Sbjct:   70 GAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYS--DTGRNWKPYHQD-GNIWAFPGNINSDGVVRHELQHPIIARYVRIVPLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRFRN--KKMKTLKDVIALNFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSN-QLGPIYGHTSVMTGSLLDDHHWHSVVIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGI-PFSGKPSSSSRKNFKGCMESINYNGVNITDLARRKKLEPSN------------------------------------VGNLSFSCVEP--YTVPVFFNATSYLEVPGRLN-QDLFSVSFQ--FRTWNPNGLLVFSHFADNLGNVEIDLTESK 430          

Query:  480 NDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQ--FDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAE-GDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNI-LDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQ-NFIGCIEEMVFD----GLYIIRDARRKVNMAAN 1145
            N N V +T+L     AR  ++ P     +       F C+ +P+T    F+  S     L+ PGR  Q     + F+F+T N NGL++++   D    + I++  S++      G  +N+    M  I + +GS L+D QWH+V     E    +T+D  +     T+  + +        GG  N       SV+Q +F GC++ +  D     LY +  A+RK    AN
Sbjct:  341 NYNGVNITDL-----ARRKKLEPSNVGNLS------FSCV-EPYTVPVFFNATSY----LEVPGRLNQDLF-SVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKV------GVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEV--AQRKPGSFAN 546          

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQV----TYNTFQYFTKDISLGKDFYIGG---------GRAAVSSFQGCLRNIYINNVQVNY------DPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDG------------------SAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSS--NDFKKYIIIKVNNNGGITIEFDVGFTR--YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGR---------NFSQVSKLGFTGCIYRLQFNNIFPLK-MLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIP-----------DWQRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTN---QPDVAGKEW 4105
            + G   +DG WH V     +N   LT+  D+     T +  Q     +  G+ ++ GG               SFQGC++ I +++  VN        P +F +++    C++ID C+PN C+    C+Q   +F C C  TGY+G  CH S    SC   + +  G Q+S    +D DGSG L P +V C+ +   + T + H    +  +V  + +  S  + LVY +A  D ++ +   + YCEQ ISY C  ++LL  P G         + WWVG+  +  +YWGG  PGIQKC CGI+  C+     CNCD D       + D+G L+ K  LPV++V +GDT    +G  + ++VGPLRC GD  + N  +F    S L+      E   D+ F FKT     V L+++ K++  F ++ ++    +  +F++G G +EI+      LND+ WH +  ERN K++ L +D   P   ++ P   +T     S+L VG +     G++GC  +L +NGV  DL+       G   GC+  CT     C N G+C E Y GY C+C  T Y G  C ++VGA F +G                  S VE   D  +      +E I   F T      LL +SS   DF   + + V   G + I +++G TR  Y + TD+  ++ N Q H++   R +  +T  +++D Y  +       L ++SD   + P  +++G+            + +  GFTGC+ R+QFN I PLK  L       +V + G  + E+NCG   +           +      + + D P              R   I+G ++AV+   IL  L+F  R     +G Y T EAKGA+  ++AD AI     N     D + KEW
Sbjct:  448 SSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQ-----VKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEVAQRKPGSF-ANVSIDMCAIIDRCVPNHCERGGKCSQTWDSFKCTCDETGYTGATCHNSIYEPSCE--AYKHLG-QTSNYYWIDPDGSGPLGPLKVYCNMTEDKVWTIVSHDLQMQTTVVSYNPEKHSV-IQLVY-SASMDQISAITDSAEYCEQYISYFCKMSRLLNTPDG-------SPYTWWVGKANEKHYYWGGSGPGIQKCACGIERNCTDPKYYCNCDADY---KQWRKDAGFLSYKDHLPVSQVVVGDTDR--QGSEAKLSVGPLRCQGDRNYWNAASFPNPSSYLHFSTFQGETSADISFYFKTLTPWGVFLENMGKED--FIKLELKSATEVSFSFDVGNGPVEIVVRSPTPLNDDQWHRITAERNVKQASLQVDR-LPQQIRKAPTEGHTRLELYSQLFVGGAGG-QQGFLGCIRSLRMNGVTLDLEERAKVTSGFISGCSGHCTSYGTNCENGGKCLERYHGYSCDCSNTAYDGTFCNKDVGAFFEEGMWLRYNFQAPATNARDSSSRVENAPDQQNSHPDLAQEEIRFSFSTTKAPCILLYISSFTTDF---LAVLVKPTGSLQIRYNLGGTREPYNIDTDH-RNMANGQPHSVNNTRHE--KTIILKLDHYPSVSYH----LPSSSDTLFNSPKSLFLGKVIETGKIDQEIHKYNTPGFTGCLSRVQFNQIAPLKAALRQTNASAHVHIQGE-LVESNCGASPLTLSPMSSATDPWHLDHLDSASADFPYNPGQGQAIRNGVNRNSAIIGGVIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGAESAESADAAIMNNDPNFTETIDESKKEW 1329          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIEGLSSISFKVTFRTFAVNGML-FYHVVDLMFTQFISLSINK 1475
            GAG WS  D +  Q++QVD   RK I+AIA QGR  S+++V  Y + +S  D    WK +    G  + F GN N + V    L +P++AR+VR+ P  WN    I +R E++GC Y      FDG   + YR     + ++T  D I  +FKTS   G+IL+ EG Q DYIT+E+ +++L + +NLG+   + P      +  GS+LDD+ WH V I R  + +N+TLDR         +F +L+L+  I+ GG+  F+GK   S  +NF GC+E + ++G+ I   ARRK    +N                                    VGN+   C  P  +   + F +     + G++  + L S+SF+  FRT+  NG+L F H  D +    I L+ +K
Sbjct:   70 GAGGWSPSDSDHYQWLQVDFGNRKQISAIATQGRYSSSDWVTQYRMLYS--DTGRNWKPYHQD-GNIWAFPGNINSDGVVRHELQHPVIARYVRVVPLDWNGEGRIGLRIEVYGCSYWADVINFDGHVVLPYRFRN--KKMKTLKDVIALKFKTSESEGVILHGEGQQGDYITLELKKAKLVLSLNLGSN-QLGPIYGHTSVMTGSLLDDHHWHSVIIERQGRSINLTLDRSMQHFRTNGEFDYLDLDYEITFGGI-PFSGKPSSSSRKNFKGCMESINYNGINITVLARRKKLEPSN------------------------------------VGNLSFSCVEP--YTVPVFFNATSYLEVPGRLN-QDLFSVSFQ--FRTWNPNGLLVFSHFADNLGNVEIDLTESK 430          

Query:  519 IVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQ--FDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAE-GDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNI-LDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQ-NFIGCIEEMVFD----GLYIIRDARRKVNMAAN 1145
            ++AR  ++ P     +       F C+ +P+T    F+  S     L+ PGR  Q     + F+F+T N NGL++++   D    + I++  S++      G  +N+    M  I + +GS L+D QWH+V     E    +T+D  +     T+  + +        GG  N       SV+Q +F GC++ +  D     LY +  A+RK    AN
Sbjct:  349 VLARRKKLEPSNVGNLS------FSCV-EPYTVPVFFNATSY----LEVPGRLNQDLF-SVSFQFRTWNPNGLLVFSHFADNLGNVEIDLTESKV------GVHINITQTKMSQIDISSGSGLNDGQWHEVRFLAKENFAILTIDGDEASAVRTNSPLQVKTGEKYFFGGFLNQMNNSSHSVLQPSFQGCMQLIQVDDQLVNLYEV--AQRKPGSFAN 546          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTK-DISLGKDFYIGGG---------RAAVSSFQGCLRNIYINN-----VQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAV------------EITLD----YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARL---DKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            G S +DG+WHSV +   ++++T+  D    +  Q  T+  I  G  +Y GG             + +FQGC+R I+I+N     + V        S +    CS+ D C+PN C+H   C+Q   TF CNCS TGY+G  CH S    SC     R  G  ++    +D DGSG L P QV C+ +   I T+ V HNN +   V G      + + L Y     + L  ++  S +CEQ ++Y C  ++LL  P G         F WW+GR  +   YWGG  PG+Q+C+CG+  +C      CNCD D   +     D+G L+ K  LPVT++ + DT        +   +GPLRC GD  F N ++F    S L+ P   AE   D+ F FKTT  + V L+++  ++     +R+       +TF +  G   +E++V++   LNDN WH +R ERN KE+ L +D + P   +E  +  +     +S+L VG + S   G++GC  +L +NG   DL+       G+  GC   C+   + C N G+C E YSGY+C+C  +PY G  C +EV A F  G++V             I+L     Y+D   S  +E I   F T      LL ++S+  + Y+ + +  NG + + + +     +V      +  N + H LK  R   G+   IQVD    +  +F S +   +   L       ++ +    ++ + LGF GC+  +Q+N + PLK       +  V V GT + E++CG
Sbjct:  442 GSSLNDGLWHSVSINARRDRITLSLDNDAASPAQDTTRVQIYSGNSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKDLISVQQGSLGNFSDLHIDLCSIKDRCLPNYCEHGGFCSQSWTTFYCNCSNTGYTGATCHNSLYEQSCE--VYRHQG-NTAGFFYIDSDGSGPLGPLQVYCNITEDKIWTS-VQHNNTELTHVRGANPEKPYTMALDYG-GSMEQLEAMIDSSEHCEQEVAYHCRRSRLLNTPDG-------TPFTWWIGRSNEKHPYWGGAPPGVQQCECGLDESCLDVRHFCNCDAD---KDEWTNDTGFLSFKDHLPVTQIVITDTNRS--NSEAAWRIGPLRCYGDRHFWNAVSFYTEASYLHFPTFHAEFSADISFFFKTTALSGVFLENLGIKD----FIRLEISSPSEITFAIDVGNGPVELIVHSPSLLNDNQWHYIRAERNLKETSLQVD-SLPRMTRETSEEGHFRLQLNSQLFVGGTSSRQKGFLGCIRSLHLNGQKLDLEERAKVTSGVRPGCPGHCSTYGSICHNGGKCVEKYSGYFCDCTNSPYEGPFCKKEVSAVFEAGTSVTYMFQEPYPVTKNISLSSSAIYADAAPS--KENIAFSFVTAQAPSLLLYINSS--QDYLAVLLCKNGSLQVRYQLSKEETQVFNIDAENFANRRMHHLKINRE--GRELAIQVDHQLRLSYNFSSEVEFRAIRSLTLGKVREHLGLDSEIAKANTLGFVGCLSSVQYNQVAPLKAALRHATIAPVTVQGT-LMESSCG 1199          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNL---GAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGN 1151
            G G WS  D N QQ++Q+DL  R  ITA+A QGR GS+++V  Y + FS  D    WK ++      + F GN N ++V    L + + AR VR  P  WN    I +R E++GC YK   A FDG+S ++YR +Q  + + T  D I  +FK+   +G++ + EG + D+IT+E+ + RL + +NL     +++ +P S    +  GS+LDD QWH V I R  K +N ++D+         +   L+++  +S GG+    GK G  + +NF GCIE + ++G+ II  A+R+ +    GN
Sbjct:   63 GTGGWSPADSNAQQWLQMDLGNRVEITAVATQGRYGSSDWVTSYSLMFS--DTGRNWKQYKQE-DSIWTFAGNMNADSVMHHKLLHSVRARFVRFVPLEWNPSGKIGMRVEVYGCSYKSDVADFDGRSSLLYRFNQ--KLMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLALHLNLDDSKPRLSSSPPS----VTLGSLLDDQQWHSVLIERVGKQVNFSVDKHTQHFRTKGEADALDIDYELSFGGI-PVPGKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYTGN 355          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTK-DISLGKDFYIGGG---------RAAVSSFQGCLRNIYINN-----VQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD----------------YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVD------------DYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            G   +DG+WHSV +   +N++T+  D    +     ++  I  GK +Y GG             + +FQGC+R I+I+N     + V        S +    CS+ D C+PN C+H   C Q   TF CNCS TGY+G  CH S    SC     R     ++    VD DGSG L P QV C+ +   I  T V HNN +   V+G      + + L Y     + L  L+  S YCEQ + Y C  ++LL  P G         F WW+GR  +   YWGG +PG+Q+C CG++ +C  +   CNCD D+        D+G+ + K  LPVT++ + DT        +   +GPLRC GD  F N ++FS   S L+ P    E   D+ F FKTT  + V L+++  ++  FF  R+       VTF +  G   IE++V +   LNDN WH +R E N KE+ L +D N P + +E  +  +     +S+L VG + S   G++GC  +L++NG   DL+       G+  GC   C+   + C N G+C E ++GY C+C  +PY G  C +E+ A F  G++V                     Y+D  ++  +E I + F T      LL ++ +  + ++ I ++ NG + + + +      V      +L N + H +K  R   G   +IQ+D            ++R ++   +  ++   D  LD           ++ + LGF GC+  +Q+N+I PLK       +  V V  T + E++CG
Sbjct:  442 GSGLNDGLWHSVSINARRNRVTLTLDNDAASPAPDTSRIQIYSGKSYYFGGCPDNLTDSQCLNPIKAFQGCMRLIFIDNQPKDLISVQQGSLGSFSDLHIDLCSIKDRCLPNYCEHGGHCDQTWTTFYCNCSGTGYTGATCHDSIYEQSCEVYRHR---GHTAGFFYVDSDGSGPLGPLQVYCNITEDKIWMT-VQHNNTELTRVQGSSPENPYSMTLNYG-GSMEQLEALIDGSEYCEQEVIYHCRRSRLLNTPDGA-------PFTWWIGRSTERHPYWGGAVPGVQQCGCGLEESCLDSRHFCNCDADI---DEWANDTGLFSFKDHLPVTQIIIMDTNRT--NSEAAWRIGPLRCYGDRHFWNAVSFSTEASYLHFPTFHTEFSADISFFFKTTALSGVFLENLGIKD--FF--RLEMSSPSEVTFAIDVGNGPIELLVQSPYPLNDNQWHYIRAETNLKETSLQVD-NLPQSMREASEGGHFRLQLNSQLFVGGTSSRQKGFLGCIRSLLLNGHKVDLEERAKVTSGVRPGCPGHCSSYGSNCHNGGKCVEKHTGYSCDCTNSPYEGPFCRKEISALFDSGTSVTYMFQEPYPVTKNTSLSSSAIYTD--LAPFKETIMLSFMTTQAPTLLLYLNFSS-QNFLAILLSRNGSLQVRYRLSKDESHVFNMDTENLANRRVHQVKISRD--GPELSIQMDQQLFSYSFSPEVEFRTLRSLVLGKVTETLD--LDP--------EVARANTLGFVGCLSSVQYNHIAPLKAALRHASIAPVTVQKT-LTESSCG 1199          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQP---FLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK--VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNL-GAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGN 1151
            G G WS  D N QQ++Q+DL  R  ITA+A QGR GS+++V  Y + FS  D    W+    PY Q    + F GN N ++V    L + + AR VR  P  WN    I +R E +GC Y+   A FDG+S ++YR +Q  + + T  D I  +FK+   +G++ + EG + D+IT+E+ + RL + +NL  +K  ++  S   ++  GS+LDD  WH V + R  K  N T+D          D   L+++  +S GG+     K G  + +NF GCIE + ++G+ II  A+R+ +   +GN
Sbjct:   63 GTGGWSPADSNAQQWLQIDLQNRVEITAVATQGRYGSSDWVTSYRLMFS--DTGHNWQ----PYNQEDSIWTFVGNMNSDSVVHHKLLHSVRARFVRFVPLEWNPNGKIGMRVEAYGCSYRSDVADFDGRSSLLYRFNQ--KTMSTLKDVISLKFKSMQGDGVLFHGEGQRGDHITLELQKGRLALYLNLDDSKARLS--STVPLVILGSLLDDQHWHSVLLERVGKQANFTVDMNTQHFRTKGDTDSLDIDYELSFGGI-PVPSKPGTFLKKNFHGCIENLYYNGVNIIDLAKRRKHQIYSGN 355          

Query: 1478 TGYLTVEVTLDGVLPIAYSIPNPDLTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYD---PKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN-LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITD---PYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTG-IRENNCG----QXXXXXXXXXXXXXXXXXXXXFNITTDIPDWQRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTNQPDVAGKEWW 4108
            TG+LT+E+ L GV  I YS+ N D  A   +F+DG+WHSV+  +++N +T++ D + Y T Q  T  +   K  YIGGGR    SFQGCLR I IN + V +D   P     SI NG+C + D C PNPCKHEAPC+Q G TF C+C+ TGY+G VCHQS+  TSCSE  L +A  QS+  +T+D+DGSG L P +V CDF+  N   TI+HH+   D +V+G+  PGS+R  L Y  ADR+ L ELVRR+  C+QS++Y+C+NAKLL+LP GGGT   N+A+GWWV + G+P FYWGGG+PG+QKC CG++GTC+G+S TCNCD D  + T    D+G+L  K  LPV EVR GDT    + K +I  VGPLRC GD LFDNT+TF K D+ L LPP+++E  FDM F+F+TT+++AVI+Q+  + ++QFFEVRIR G +LRV FN+G GI++ EV   + LNDN WHVVRFERNRKE+RLI+D   P    E  +R +  F+FD  L VG++Q+FTDGYVGC SNL++NGV+QD++  +      YG+S GC PKC  NPCLNRGEC E YS Y CECGLTPYRG++CGR++G +F  G  ++I L     ++ T+EEYI++GFKTK K+G L+++       YII+KVNNNGGITIEFDVGF RYEVTT+Y VDL NDQHH + AWR+D+G  W+++VDDY  + + F ++LS  +D RLD P  +Y+GRN +     GF GCIY  Q+NNIFPL + + +    ++ +   G +RE+ CG      E  P        I   I    +T D+   +R  II GV+  +I ++  I+L+ F R+FT E GDY TREAK A  M TAD AI+YG+T QP+V GKEWW
Sbjct:  450 TGHLTLEIILPGVYIIKYSVRNKDSAAINGTFADGLWHSVKFSMSQNLVTLIIDNIVYTTVQNMTLPLYFDKVSYIGGGRPQRYSFQGCLRQIRINGIDVEWDKLDPSARHRSIINGSCMIQDRCNPNPCKHEAPCSQTGATFYCDCTNTGYAGAVCHQSEYFTSCSEAGLFYALQQSTINITIDMDGSGVLEPIEVTCDFTDQNTVMTILHHDAPDDTIVDGYQAPGSYRRKLNYGRADRETLGELVRRAVECDQSLTYQCWNAKLLQLPAGGGTTYENRAWGWWVSQDGRPQFYWGGGVPGLQKCACGVEGTCTGDSLTCNCDSD-GSATPPLVDTGLLQFKKHLPVMEVRFGDTGGINDDKRAIYRVGPLRCYGDKLFDNTVTFRKLDANLELPPLYSEFAFDMSFIFRTTITDAVIMQNNGRASKQFFEVRIRNGNSLRVAFNVGNGIQLTEVTTAHWLNDNSWHVVRFERNRKETRLIVDTQEPSIIIESSERSFRGFDFDQPLYVGTTQAFTDGYVGCLSNLLINGVVQDMRGLVERGVYTYGLSAGCKPKCATNPCLNRGECVEYYSHYLCECGLTPYRGFICGRQIGGTFNSGPMIKILLGRPKDRLGTVEEYIQVGFKTKSKRGILIEMKGEGESNYIIVKVNNNGGITIEFDVGFKRYEVTTNYDVDLTNDQHHMVYAWRTDLGTKWHLKVDDYNEVVEDFGNLLSPTADVRLDDPYVIYMGRNDTMQPADGFDGCIYAAQWNNIFPLHLAYEEPRNASIEMIPAGSVREDLCGFIEILPEEEPVEIRPSPAIPANITLPKVTEDLEHEKR--IIAGVVSGLILIMSAIILLLFCRHFTFEHGDYRTREAKDASRMKTADMAIQYGRTGQPEVQGKEWW 1335          

Query:  129 MSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKV----NMAANGNRN--WQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGN--VGSDCPPPSSFQNVITFPSIDSNGIYGKVTIE-GLSSISFKVTFRTFAVNGMLFYHVVD 1436
            M+DR+NGIKD+QI +SS FS  T   Y RLH SD         GAGAW A D + +Q++Q+DLL+RKVI +IA QGRQG+ ++++DYY+ ++D + P  W + +D  GQP LF GN +DNTV   N +YPIVAR +R+ PQRWN +IS+R ELFGC Y+P+ A  DG S +  RLD PGRA QT  D+I FRF+T  +NGLILY +  Q DY  +E++R RLRVR+NLG  V ++ E  DNI+DAGS+LDD+QWHDV+I R EK+LN+++DR+K+WRN+++ F+H+N+NRN+S+GGL +F  +RG+SV QNFIGC+EE +F+G++IIRD +R +     ++ N   +  W++ L YP  NS +WWG  +T+  L I+   I G+  +G++CP       V+TFP +    ++ K+  + G +++ F+  FR+    G+LFYH VD
Sbjct:    1 MTDRFNGIKDNQITASSSFSDQTMPYYGRLHISDE--------GAGAWIALDQDDKQWLQIDLLKRKVIQSIATQGRQGARQWIQDYYIYYTDSNEPIHWSVIKDDLGQPLLFDGNVDDNTVQFNNFSYPIVARFLRLNPQRWNNLISLRMELFGCDYRPFVAHLDGTSWIDLRLDLPGRATQTYIDEINFRFRTKEVNGLILYGDSSQGDYFCVELYRGRLRVRVNLGT-VPLSNEPTDNIVDAGSLLDDDQWHDVQIIREEKNLNISVDRIKVWRNISAIFVHMNMNRNLSIGGLPDFTNRRGLSVSQNFIGCLEEFIFNGVHIIRDTQRSLMKIPQLSINSQLDIPWEEALGYPKRNSFLWWGPPVTQDSLNISGLAIGGSGILGTECPSGIIDNTVLTFPDVQQYIVFLKIERDGGTNALQFEFGFRSLNRGGILFYHTVD 436          

Query: 1481 GYLTVEVTLDGVLPIAYSIPNPDLTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYD---PKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN-LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITD---PYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRV-SGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIPDWQR---TGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTNQPDVAGKEWW 4108
            G+L +E+ L GV  I Y+I N D  A   +F+DG+WH V+  + ++ + ++ D +TY T Q  T  +S  +  YIGGGR     FQGC+R I +N++ V +D   P     SI NG+C + D C PNPCKHEAPC Q+G TF CNC+ TGY+G VCHQS+  TSC+E  L +A   +   +T+D+DGSG L P +V CDF+      TI+ H+  + V+V+G+  PGS+R  LVY+ ADR+ L ELVRR+ +CEQ+I+YKC+N+ LL+LP GGGT   N+A+GWWV R+GQP FYWGGG+PG+QKC CG+ GTCSG+S TCNCD D  + T    D+G+L  K DLPVTEVR GDT    + K +   VGPLRC GD+LFDNT+TF + D+ L LPP+++E  FDM F F+TTV++AVI+Q+  +  QQFFE+RIR G ++RV FN+G GI++ EV   + LNDN WHVVRFERNRK +RL +D   P+   E  +R +  F+FD  L VG++Q+FTDG+VGC SNL++NGV+QD++  +      YG+S GC PKC  NPCLNRGEC E YS Y CECGLT YRG++CGREVG +F +G  + I LD    ++ T+EEYI++GFKTK K+G L+++       YII+KVNNNGGITIEFDVGF R+EVTT+Y +DLCNDQHH + AWR+DMG  W+++VDDY  I + F S LS ++D RLD P+ +++GRN +  +  GF GCIY  Q+NN FPL M + D PLPNV +     +RE+ CG  EI+P  EP+EI+  P IP  NIT     +++     II GV+  +I ++ ++LL+ F R+FT ERGDY+TREAKGA ++ TAD AI++G+T QP+V GKEWW
Sbjct:  459 GHLILEILLPGVNIIKYTIQNRDPAAPDGTFADGLWHDVQFNMAQDSVILMVDNITYATTQKTTVPLSFDRVSYIGGGRPQRYGFQGCMRQIRVNSLDVIWDKLDPSVRHRSIVNGSCLIQDRCSPNPCKHEAPCYQNGDTFFCNCTDTGYAGAVCHQSEYFTSCAEAGLFYALRDAYINITIDMDGSGVLKPIKVTCDFTDPTTVITILPHDLTRPVVVDGYQAPGSYRRRLVYDRADRETLGELVRRAVHCEQAITYKCWNSYLLRLPPGGGTTLENRAWGWWVSRKGQPQFYWGGGVPGLQKCACGVDGTCSGDSVTCNCDSD-GSNTPPLVDTGLLKFKDDLPVTEVRFGDTGGLNDNKRAEYYVGPLRCYGDTLFDNTVTFRRADANLELPPLYSEFAFDMSFTFRTTVTDAVIMQNNGRATQQFFEIRIRNGNSIRVAFNVGNGIQLAEVSTAHWLNDNRWHVVRFERNRKSTRLSVDTQEPIVIVEAIERSFRGFDFDQPLSVGTTQAFTDGFVGCLSNLLINGVVQDMRGLVERGVFTYGLSPGCKPKCDSNPCLNRGECVEHYSHYLCECGLTAYRGFICGREVGGTFNNGPMIMILLDRPHDRLGTVEEYIQVGFKTKSKRGILMEMRGAGDTNYIIVKVNNNGGITIEFDVGFKRFEVTTNYDIDLCNDQHHMVYAWRTDMGTKWHLKVDDYNEIVEDFTSYLSPSADVRLDDPSVIFMGRNTTMQAADGFDGCIYAAQWNNFFPLHMAYQDPPLPNVLMFPNASVREDLCGFIEILPEAEPLEIRPSPAIPT-NITPPAQAFEKEREQRIIAGVVTGLILMLTIVLLVLFCRHFTFERGDYETREAKGASQVQTADMAIQFGQTGQPEVQGKEWW 1343          

Query:  129 MSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK------VNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLG--IANFDIVGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIE-GLSSISFKVTFRTFAVNGMLFYHVV--DLMFTQF 1454
            M+DR+NGIKD QI +SS FS  T   Y RLH SDAFL+  ++ GAGAW A D + QQ++Q+DL +RKVI ++A QG+QG+ ++V+DYY+ ++D DVP  W + +D  GQP LF GN +D+ V + N +YPIVAR++R+ PQRW+ +I++R E+FGC Y+P+ A FDG S +  RLD PGRA QT  D+++FRF+T  INGL+LY +  Q DY  +E+FR RLRV +NLG  V  + E  DN +DAGS+LDD+QWHDV I RA+K+LN+++DR+++WRNL++ FIHLN+NRN+S GGL  FA +RG++V QNF GCIEE+VF+G+++IRDA+R       V+    G   W + L YP  N  +WWG  +TESQL          G +G+ CPP  +   VI FP+     ++ K+  + G++++ F   FRT    G++FYH V  DL F  F
Sbjct:    1 MTDRFNGIKDDQITASSSFSDQTMPYYGRLHLSDAFLFDQSLKGAGAWVALDQDDQQWIQIDLKKRKVIISVATQGKQGARQWVQDYYIMYTDSDVPVHWSIIKDNLGQPLLFDGNVDDSGVRMNNFSYPIVARYIRLNPQRWHNLIALRMEVFGCDYRPFVAHFDGTSWIDLRLDLPGRATQTAVDEVRFRFRTKEINGLLLYGDSSQNDYFCVELFRGRLRVSVNLGT-VPSSTEPTDNTVDAGSLLDDDQWHDVHIIRAQKNLNISVDRIQVWRNLSAIFIHLNMNRNLSAGGLPFFANRRGLTVNQNFKGCIEELVFNGVHLIRDAQRSLFGAQIVSPKDAGTLRWDEALGYPKRNPFLWWGPPITESQLKISGFGIGGSGRLGTTCPPVITDDTVIMFPATQQYVVFLKIERDGGVNTLQFSFQFRTLNRGGIMFYHTVDKDLNFVSF 452          

Query: 1481 GYLTVEVTLDGVLPIAYSIPNPDLTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYD---PKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN-LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITD---PYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRV-SGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIPDWQR---TGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTNQPDVAGKEWW 4108
            G+L +E+ L GV  I Y+I N D  A   +F+DG+WH V+  + ++ + ++ D +TY T Q  T  +S  +  YIGGGR     FQGC+R I +N++ V +D   P     SI NG+C + D C PNPCKHEAPC Q+G TF CNC+ TGY+G VCHQS+  TSC+E  L +A   +   +T+D+DGSG L P +V CDF+      TI+ H+    V+V+G+  PGS+R  LVY+ ADR+ L ELVRR+ +CEQ+I+YKC+N+ LL+LP GGGT   N+A+GWWV R+GQP FYWGGG+PG+QKC CG+ GTCSG+S TCNCD D  + T    D+G+L  K DLPVTEVR GDT    + K +   VGPLRC GD+LFDNT+TF + D+ L LPP+++E  FDM F F+TTV++AVI+Q+  +  QQFFE+RIR G ++RV FN+G GI++ EV   + LNDN WHVVRFERNRK +RL +D   P    E  +R +  F+FD  L VG++Q+FTDG+VGC SNL++NGV+QD++  +      YG+S GC PKC  NPCLNRGEC E YS Y CECGLT YRG++CGREVG +F +G  + I LD    ++ T+EEYI++GFKTK K+G L+++       YII+KVNNNGGITIEFDVGF R+EVTT+Y +DLCNDQHH + AWR+DMG  W+++VDDY  I + F S LS ++D RLD P+ +++GRN +  +  GF GCIY  Q+NN FPL M + D PLPNV +     +RE+ CG  EI+P  EP+EI+  P IP  NIT     +++     II GV+  +I ++ ++LL+ F R+FT ERGDY+TREAKGA ++ TAD AI++G+T QP+V GKEWW
Sbjct:  492 GHLILEILLPGVNIIKYTIQNRDPAAPDGTFADGLWHDVQFNMAQDSVILMVDNITYATTQKTTMPLSFDRVSYIGGGRPQRYGFQGCMRRIRVNSLDVIWDKLDPSVRHRSIVNGSCLIQDRCSPNPCKHEAPCYQNGDTFFCNCTDTGYAGAVCHQSEYFTSCAEAGLFYALRDAYINITIDMDGSGVLKPIKVTCDFTDPTTVITILPHDLTLPVVVDGYQAPGSYRRRLVYDRADRETLGELVRRAVHCEQAITYKCWNSYLLRLPPGGGTTLENRAWGWWVSRKGQPQFYWGGGVPGLQKCACGVDGTCSGDSVTCNCDSD-GSNTPPLVDTGLLKFKDDLPVTEVRFGDTGGLNDNKRAEYYVGPLRCYGDTLFDNTVTFRRADANLELPPLYSEFAFDMSFTFRTTVTDAVIMQNNGRATQQFFEIRIRNGNSIRVAFNVGNGIQLAEVSTAHWLNDNRWHVVRFERNRKSTRLSVDTQEPTVIVEAIERSFRGFDFDQPLSVGTTQAFTDGFVGCLSNLLINGVVQDMRGLVERGVFTYGLSPGCKPKCDSNPCLNRGECVEHYSHYLCECGLTAYRGFICGREVGGTFNNGPMIMILLDRPRDRLGTVEEYIQVGFKTKSKRGILMEMRGAGDTNYIIVKVNNNGGITIEFDVGFKRFEVTTNYDIDLCNDQHHMVYAWRTDMGTKWHLKVDDYNEIVEDFTSYLSPSADVRLDDPSVIFMGRNTTMQAADGFDGCIYAAQWNNFFPLHMAYQDPPLPNVLMFPNASVREDLCGFIEILPEAEPLEIRPSPVIPT-NITPPAQAFEKEREQRIIAGVVTGLILMLTIVLLVLFCRHFTFERGDYETREAKGASQVQTADMAIQFGQTGQPEVQGKEWW 1376          

Query:   90 SQDCSILPERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK------VNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDI--VGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIE-GLSSISFKVTFRTFAVNGMLFYHVV--DLMFTQF 1454
            +Q C   P  PLGM+DR+NGIKD QI +SS FS  T   Y RLH SDAFL+  ++ GAGAW A D + QQ++Q+DL +RKVI ++A QG+QG+ ++V+DYY+ ++D DVP  W + +D  GQP LF GN +D+ V + N +YPIVAR++R+ PQRW+ +I++R E+FGC Y+P+ A FDG S +  RLD PGRA QT  D+++FRF+T  INGL+LY +  Q DY  +E+FR RLRV +NLG  V  + E  DN +DAGS+LDD+QWHDV I RA+K+LN+++DR+++WRNL++ FIHLN+NRN+S GGL  F+ +RGI+V QNF GCIEE+VF+G+++IRDA+R       V+    G   W + L YP  N  +WWG  +TESQL I  F I   G +G+ CPP  +   VI FP+     ++ K+  + G++++ F   FRT    G++FYH V  DL F  F
Sbjct:   21 TQTCDYYPFVPLGMTDRFNGIKDDQITASSSFSDQTMPYYGRLHLSDAFLFDQSLKGAGAWVALDQDDQQWIQIDLRKRKVIISVATQGKQGARQWVQDYYILYTDADVPVHWSIIKDNLGQPLLFDGNVDDSGVRMNNFSYPIVARYIRLNPQRWHNLIALRMEVFGCDYRPFVAHFDGTSWIDLRLDLPGRATQTAVDEVRFRFRTKEINGLLLYGDSSQNDYFCVELFRGRLRVSVNLGT-VPSSTEPTDNTVDAGSLLDDDQWHDVHIIRAQKNLNISVDRIQVWRNLSAIFIHLNMNRNLSAGGLPFFSHRRGITVSQNFKGCIEELVFNGVHLIRDAQRSLFGSQIVSAKDAGILRWDEALGYPKRNPFLWWGPPITESQLNITGFGIGGSGRLGTTCPPVITDDTVIMFPATQQYVVFLKIERDGGVNALQFSFQFRTLNRGGIMFYHTVDKDLNFVSF 485          

Query: 1478 TGYLTVEVTLDGVLPIAYSIPNPDLTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYD---PKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN-LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITD---PYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVR-VSGTGIRENNCG---QXXXXXXXXXXXXXXXXXXXXFNITTDIPDWQRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTNQPDVAGKEWW 4108
            +G+L +E+ L GV  I Y++ N D  A   +F+DG+WHSV+  +++N + ++ D + Y T Q  T  +   K  YIGGGR    SFQGCLR I IN + V +D   P     SI NG+C + D C PNPCKHEAPC+Q G TF C+C+ TGY+G VCHQS+  TSCSE  L +A  QS+  +T+D+DGSG L P +V CDF+  N   T++HH+   DV+V+G+  PGS+R  L Y  ADR+ L ELVRRS  C+QS++Y+C+NAKLL+LP GGGT   N+A+GWWV + G+P FYWGGG+PG+QKC CG++GTC+G+S TCNCD D  + T    D+G+L  K  LPV EVR GDT    + K +I  VGPLRC GD+LFDNT+TF K D+ L LPP+++E  FDM F+F+TT+++AVI+Q+  + ++QFFEVRIR G +LRV FN+G GI++ EV   + LNDN WHVVRFERNRKE+RLI+D   P    E   R ++  N      +  S +FTDGYVGC SNL++NGV+QD++  +      YG+S GC PKC  NPCLNRGEC E YS Y+CECGLTPYRG++CGR++G +F  G  V+I LD    ++ T+EEYI++GFKTK K+G L+++       YII+KVNNNGGITIEFDVGF RYEVTT+Y VDL NDQHH + AWR+D+G  W+++VDDY  + + F ++LS  +D RLD P  +Y+GRN +     GF GCIY  Q+NNIFPL +++ +    +V  +    +RE+ CG          +E       P    F   TD  + ++  II GV+  VI ++ +I+L+ F R+FT E+GDY TREAKGA  M TAD AI+YG+T QP+V GKEWW
Sbjct:  489 SGHLALEIILPGVYIIKYTVRNKDSAAINGTFADGLWHSVKFSMSQNLVILIIDNIKYTTVQNMTLPLYFDKVSYIGGGRPQRYSFQGCLRQIRINGIDVEWDKLDPATRHRSIINGSCMIQDRCNPNPCKHEAPCSQTGSTFYCDCTNTGYAGAVCHQSEYFTSCSEAGLFYALQQSTINITIDMDGSGVLEPIEVTCDFTDPNTVMTMLHHDAPDDVVVDGYQAPGSYRRKLNYGRADRETLGELVRRSIECDQSLTYQCWNAKLLQLPAGGGTTYENRAWGWWVSQDGRPQFYWGGGVPGLQKCACGVEGTCTGDSLTCNCDSD-GSTTPPLVDTGLLQFKDHLPVMEVRFGDTGGINDDKRAIYRVGPLRCYGDTLFDNTVTFRKLDANLELPPLYSEFAFDMSFIFRTTITDAVIMQNNGRASKQFFEVRIRNGNSLRVAFNVGNGIQLTEVTTAHWLNDNRWHVVRFERNRKETRLIVDTQEPAVIIESSQRSFSVANN-----LEYSAAFTDGYVGCLSNLLINGVVQDMRGLVERGIYTYGLSAGCKPKCASNPCLNRGECVEYYSHYFCECGLTPYRGFICGRQIGGTFNSGPMVKIFLDRPKDRLGTVEEYIQVGFKTKSKRGILMEMRGEGESNYIIVKVNNNGGITIEFDVGFKRYEVTTNYDVDLTNDQHHMVYAWRTDLGTKWHLKVDDYNEVVEDFSNLLSPTADVRLDDPYVLYMGRNDTMQPADGFDGCIYAAQWNNIFPLHLIYEEPRNASVEMLPADSVREDLCGFIEILPEEEPVEIRPSPAIPTNITFPEITDDAEREKR-IIAGVVSGVILILSVIILVLFCRHFTFEQGDYRTREAKGASRMKTADMAIQYGRTGQPEVQGKEWW 1369          

Query:   24 LKEMLKIIIVYLFFNYFYNDIASQDCSILPERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARR---KVNMAANGNR---NWQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGN--VGSDCPPPSSFQNVITFPSIDSNGIYGKVTIEGLSSI-SFKVTFRTFAVNGMLFYHVVD 1436
            +K  L ++ + L  N+      +Q+C   P  PLGM+DRYNGIKDSQI +SS FS  T   Y RLH SDA+L+   + GAGAW + D + +Q++Q+DLL+RKVI +IA QGRQG+ ++++DYY+ ++D + P  W + +D  GQP LF GN +DNTV   N TYPIVAR++R+ PQRWN +IS+R ELFGC Y+P+ A  DG S +  RLD PGRA QT  D+I FRF+T  INGLILY +  Q DY+ +E++R RLRVR+NLG  V ++ E  DNI+DAGS+LDD+QWHDV+I R EK+LN+++DR+K+WRN+++ F+H+N+NRN+S+GGL +++ +RGISV QNFIGC+EE +F+G++IIRDA+R   K+    + N+    W+++L YP  +S IWWG  +T+ +L I    I G+  +G++CP       V+TFP I    ++ K+   G ++I  F+  FRT    G+LFYH VD
Sbjct:    1 MKNYLCLLSILLSVNH----ALTQECDYFPYIPLGMTDRYNGIKDSQITASSSFSDQTMPYYGRLHISDAYLFNQDLQGAGAWISLDQDDKQWIQIDLLKRKVIQSIATQGRQGARQWIQDYYIYYTDSNEPIHWSIIKDDLGQPLLFDGNVDDNTVKFNNFTYPIVARYIRLNPQRWNNLISMRMELFGCDYRPFVAYMDGTSWIDLRLDLPGRATQTYVDEISFRFRTKEINGLILYGDSSQGDYLCVELYRGRLRVRVNLGT-VPLSNEPTDNIVDAGSLLDDDQWHDVQIIREEKNLNISVDRIKVWRNISAIFVHMNMNRNLSIGGLPDYSNRRGISVNQNFIGCLEEFIFNGVHIIRDAQRSLMKLPQLLSDNQLEIPWEELLGYPKRSSFIWWGPPITQEKLNITGLTISGSGILGTECPSTVIDNTVLTFPDIQQYIVFLKIERNGGTNILQFEFDFRTLNKGGILFYHTVD 475          

Query: 1478 TGYLTVEVTLDGVLPIAYSIPNPDLTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYD---PKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEV-VVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITD---PYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVR-VSGTGIRENNCG-QXXXXXXXXXXXXXXXXXXXXFNITTDIPDWQRT-GIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTNQPDVAGKEWW 4108
            +G+L +E+ L GV  I Y++ N D  A   +F+DG+WH V+  +T + + +V D+V Y T Q  T+ +S  +  YIGGGR     FQGC+R I +N + V +D   P     SI NG+C + D C PNPCKHEAPC Q+G TF C+C+ TGYSG VCHQS+  TSC+E SL +A   S   +T+D+DGSG L P +V CDF+      T+++H+    +LV+G+  PGS+R  L Y  A+R+ L ELVRR+  CEQ+ISY+C+NA LLKLP GGGT   N+A+GWW+ R+G+P FYWGGG+PG+QKC CG++GTC+G+S TCNCD    + T    D G+L  K DLPV EVR GDT    + K +   VGPL C GD LFDNT+TF K D+ L LPP+++E  FDM F F+TT+++AVI+Q+  + +QQFFEVRIR G  +RV FN+G G+++ EV   + LND+ WHVVRFERNRKE+RLI+D   P    E  +R +  F+FD  L VG++Q+FTDG+VGC SNL++NGV+QD++  +      YG+S GC PKC  NPCLNRGEC E YS Y CECGLTPYRG++CGR+VG +F +G  ++I LD  + ++ T+EEYI++GFKTK K+G L+++       YII+KVNNNGGITIEFDVGF R+EVTT+Y +DLCNDQHH + AWR+++G  W+++VDDY  + + F   LS  +D RLD+P  +Y+GRN +     GF GCIY  Q+NN FPL+M F    LPNV+ +    IRE+ CG  E +               P   + T   D  R   II GVI  ++ ++ +I L+FF R+FT++RGDYDTREAKGA    TAD AI++G+T QP+V GKEWW
Sbjct:  508 SGHLGLEIILPGVNVIKYTVQNRDSAALNGTFADGLWHDVQFKMTTDNVLLVIDKVNYETRQKTTRPLSFDRVSYIGGGRPLKYGFQGCMRTIRVNGIDVVWDELDPSARHQSIVNGSCLIQDRCSPNPCKHEAPCYQNGDTFFCDCTNTGYSGAVCHQSEYFTSCAEASLFYALQHSVINITIDMDGSGVLEPIKVTCDFTDPTTVITVLYHDAPGYILVDGYQAPGSYRRTLKYGRANRETLGELVRRADRCEQAISYECWNALLLKLPPGGGTTLENRAWGWWINRKGRPRFYWGGGVPGLQKCACGVEGTCTGDSLTCNCDS-AGSTTPPLVDQGLLQFKDDLPVMEVRFGDTGGINDDKRARYRVGPLLCYGDKLFDNTVTFRKPDANLELPPLYSEFAFDMSFTFRTTITDAVIMQNNGRASQQFFEVRIRNGNAIRVAFNVGNGVQLTEVSTAHWLNDDRWHVVRFERNRKETRLIVDTLNPTVIVESIERSFRGFDFDQPLSVGTTQAFTDGFVGCLSNLLINGVVQDMRGLVEQGLFTYGLSAGCKPKCDSNPCLNRGECVEYYSHYLCECGLTPYRGFICGRQVGGTFNNGPMLKILLDRKEDRLGTVEEYIQVGFKTKSKKGILMEMRGAGDTNYIIVKVNNNGGITIEFDVGFKRFEVTTNYDIDLCNDQHHMVYAWRTNLGTKWHLKVDDYNEVVEDFTKYLSPTADVRLDEPWVIYMGRNDTLQPADGFDGCIYAAQWNNFFPLRMHFRSPKLPNVQSIPADSIREDLCGFIEILPVAEPLEIRPSPLIPPNVTLPTQNEDALRERRIIAGVITGLLMILSVIGLVFFCRHFTIDRGDYDTREAKGASHSKTADMAIKFGRTGQPEVQGKEWW 1393          

Query:   33 MLKIIIVYLFFNYFYN--DIASQDCSILPERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFL--------------WYPT--IPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKV------NMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDI--VGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIE-GLSSISFKVTFRTFAVNGMLFYHVVD 1436
            M  + I + FF    +   + +Q C   P  PLGM+DR+NGIKD QI +SS FS  T   Y RLH SD  L              W  +    GAGAW A D + +Q++QVDLL+RKV+T+IA QG+QG+ ++V+DYY++++D DVP  W + +D  GQP LF GN NDN V + N +YPIVAR++R+ PQRW+ +I++R ELFGC Y+P+ A FDG + +  RLD PGRA QT AD+++FRF+T  +NGL+LY +  Q DY  +E+ R RLRV +NLG  +  + E  DN +DAGS+LDD+QWHDV I R EK+LN+++DR+++WRNL++ F+H N+NRN+S GGL  ++ +RG++V +NFIGCIEE VF+G++IIRDA+R +          +    W + L YP  N  +WWG  +T+SQL I  F I   G + + CPP +    VI FP   +  ++ K+  + G +++ F   FRT    G++FYH VD
Sbjct:    1 MYSLSITWSFFILCLSLFSLKAQQCDYFPFIPLGMTDRFNGIKDEQITASSSFSDQTMPYYGRLHISDGRLFCLIAHCVSSHNLCWAQSSFTEGAGAWVALDQDDKQWIQVDLLKRKVVTSIATQGKQGARQWVQDYYIQYTDSDVPVYWSVVKDNMGQPLLFDGNVNDNGVKMNNFSYPIVARYIRLNPQRWHDLIALRMELFGCEYRPFIAYFDGTNWIDLRLDLPGRATQTAADEVRFRFRTKEVNGLLLYGDSSQHDYFCVELHRGRLRVNINLGT-LPWSDEPTDNTVDAGSLLDDDQWHDVHIIRQEKNLNISVDRIQVWRNLSAVFLHTNMNRNLSAGGLPYYSNRRGVTVDKNFIGCIEEFVFNGVHIIRDAQRSLLSQWTDPQKTSQVLRWDEALGYPSRNPLLWWGPAITQSQLNITGFAIGGSGRLQTTCPPVTKDDTVIMFPQTQTYVVFLKIERDGGGNTLQFGFQFRTLNRGGVMFYHTVD 494          

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQVTYNTFQYFTKDISLGKDFYIGG--GRAAVS----SFQGCLRNIYINN--VQVNYDPKNFDSSIRNGT---CSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQE---DPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITL-------DYSDQKISTLE-----EYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYI-VDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFS--QVSKL--------GFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            + G   +DG WHSV     ++   LT+  D+++ +        I    ++Y GG   R  +S    SFQGC++ I+++   V ++   +    S  N +   C++ID C+PN C+H   C+Q G TF C+C  TGY+G  CH S    SC E   +  G ++S +  +D DGSG L PF+V C+ +   + T + +    +  +  G  DP    +  +  +   D +N +   + +CEQ ++Y C  ++LL  P G         + WW+GR  +  FYWGG  PGIQKC CGI+  C+  +  CNCD D   Q   + D+G+L  K  LPVT+V +GD   +  G  + + VGPLRC GD  + N  +F+   S L+ P    E   D+ F FKT+ S  V L+++   N  F  + ++  + +  +F++G G +E+       LND+ WH V  ERN KE+ L +D+     H+E    P + +T     S+L VG+S     G++GC  +L +NGV  DL+       G+  GC+  C+     C N G+C E Y+GY C+C LT + G  C  +VG  F  G+ V             + + + ++E     E +   F T      L+ +SS   + Y+ + + +NG + I + +G  +   T      ++ N Q H++   R +  +   +Q+D Y  I  S    L   SD   +    +++G+ F   Q+  +        GF GC+ R+QFN I PLK            + G  + E+NCG
Sbjct:  443 SSGSGLNDGQWHSVHFLALESFAMLTINGDEMS-SVRATLPMQIRTVGEYYFGGYFPRTDLSPSQRSFQGCMQLIHLDGEPVDLHAVEQGKMGSFENVSLDMCAVIDRCVPNHCEHGGRCSQTGDTFRCSCDGTGYTGATCHTSIYEQSCEE--YKHLG-RTSDSYWIDPDGSGPLEPFRVSCNMTEDKVWTRLANDLPAQTAVNAGS-DPTQGTVLRLNYSVSTDQVNAVTSSAEHCEQHVAYACRMSRLLNSPDG-------SPYTWWIGRGNERHFYWGGSGPGIQKCACGIERNCTDPNYYCNCDAD---QRQWREDAGVLMYKDHLPVTQVVVGD--VQRSGSEARLTVGPLRCQGDRNYWNAASFNTPASYLHFPTFQGETSADISFYFKTSSSYGVFLENLG--NTDFIRLELKSAYMVSFSFDVGNGPVEMSVRSPAPLNDDQWHRVEAERNVKEAMLRLDKQ----HREVRAAPPQGHTRLQLYSQLFVGASGG-QRGFLGCIRSLKMNGVTLDLEERAKVTPGVKPGCSGHCSSYGMHCQNGGKCVEKYNGYSCDCSLTAFDGPFCTDDVGGYFESGTMVRYDFMSDSSGSSSAVKGVLSVEGNLTQEELSFSFSTSHAPSVLVYISSRT-QDYLAVVLRHNGTLQIRYSLGGLKEPFTISLDNRNMANGQPHSVNISRQE--RLIQLQLDHYPSISYS----LPEASDTEFNLVKTIFLGKVFETGQIDPVLIERYNTPGFVGCLSRVQFNRIAPLKAALRPGVPSTASIQGV-LVESNCG 1202          

Query:   87 ASQDCSILPERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            ASQ C  +   PL  S            SSS  + D    YA+L+            G G WS  D +  Q++QVDL  RK I AIA QGR  S+++ K Y + +S  D    W+ +R   G  + F GN N        L Y +VAR++R  P  W++     +R E++GC Y      FDG+  + YR     + ++   D I  RFKTS  +G++++ EG Q DYIT+E+ R++L +++NLG+    + +   ++  +GS+LDD+ WH V I R  + +N TLD+         +F HL+L+  IS GG+   + K      QNF+GC+E ++++G  I    RR+
Sbjct:   28 ASQRCDEVLATPLPYS---------AFSSSSVLAPDFGAGYAKLNRR---------VGNGGWSPLDSDRYQWLQVDLRGRKQIMAIATQGRYSSSDWTKQYRILYS--DTASNWRPYRQD-GNIWTFSGNWNSERAVRHELQYTVVARYLRFIPLEWSEEGRTGLRVEVYGCAYWADVISFDGQGVIPYRFRH--KKMKILKDVISLRFKTSKGDGVLIHGEGQQGDYITLELRRAKLVLQINLGSNQYGSIQGHTSV-SSGSLLDDDHWHSVLIERYRRSVNFTLDQQTQSFRTNGEFGHLDLDYEISFGGM-PLSAKPISGGPQNFVGCMEGILYNGDNITNLVRRR 351          

Query: 1556 ADGRSFSDGMWHSVELYLTKN--KLTVVADQVTYNTFQYFTKDISLGKDFYIGG--GRAAVS----SFQGCLRNIYINN--VQVNYDPKNFDSSIRNGT---CSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQE---DPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITL-------DYSDQKISTLE-----EYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYI-VDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFS--QVSKL--------GFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            + G   +DG WHSV     ++   LT+  D+++ +        I    ++Y GG   R  +S    SFQGC++ I+++   V ++   +    S  N +   C++ID C+PN C+H   C+Q G TF C+C  TGY+G  CH S    SC E   +  G ++S +  +D DGSG L PF+V C+ +   + T + +    +  +  G  DP    +  +  +   D +N +   + +CEQ ++Y C  ++LL  P G         + WW+GR  +  FYWGG  PGIQKC CGI+  C+  +  CNCD D   Q   + D+G+L  K  LPVT+V +GD   +  G  + + VGPLRC GD  + N  +F+   S L+ P    E   D+ F FKT+ S  V L+++   N  F  + ++  + +  +F++G G +E+       LND+ WH V  ERN KE+ L +D+     H+E    P + +T     S+L VG+S     G++GC  +L +NGV  DL+       G+  GC+  C+     C N G+C E Y+GY C+C LT + G  C  +VG  F  G+ V             + + + ++E     E +   F T      L+ +SS   + Y+ + + +NG + I + +G  +   T      ++ N Q H++   R +  +   +Q+D Y  I  S    L   SD   +    +++G+ F   Q+  +        GF GC+ R+QFN I PLK            + G  + E+NCG
Sbjct:  470 SSGSGLNDGQWHSVHFLALESFAMLTINGDEMS-SVRATLPMQIRTVGEYYFGGYFPRTDLSPSQRSFQGCMQLIHLDGEPVDLHAVEQGKMGSFENVSLDMCAVIDRCVPNHCEHGGRCSQTGDTFRCSCDGTGYTGATCHTSIYEQSCEE--YKHLG-RTSDSYWIDPDGSGPLEPFRVSCNMTEDKVWTRLANDLPAQTAVNAGS-DPTQGTVLRLNYSVSTDQVNAVTSSAEHCEQHVAYACRMSRLLNSPDG-------SPYTWWIGRGNERHFYWGGSGPGIQKCACGIERNCTDPNYYCNCDAD---QRQWREDAGVLMYKDHLPVTQVVVGD--VQRSGSEARLTVGPLRCQGDRNYWNAASFNTPASYLHFPTFQGETSADISFYFKTSSSYGVFLENLG--NTDFIRLELKSAYMVSFSFDVGNGPVEMSVRSPAPLNDDQWHRVEAERNVKEAMLRLDKQ----HREVRAAPPQGHTRLQLYSQLFVGASGG-QRGFLGCIRSLKMNGVTLDLEERAKVTPGVKPGCSGHCSSYGMHCQNGGKCVEKYNGYSCDCSLTAFDGPFCTDDVGGYFESGTMVRYDFMSDSSGSSSAVKGVLSVEGNLTQEELSFSFSTSHAPSVLVYISSRT-QDYLAVVLRHNGTLQIRYSLGGLKEPFTISLDNRNMANGQPHSVNISRQE--RLIQLQLDHYPSISYS----LPEASDTEFNLVKTIFLGKVFETGQIDPVLIERYNTPGFVGCLSRVQFNRIAPLKAALRPGVPSTASIQGV-LVESNCG 1229          

Query:  159 SQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            S   SSS  + D    YA+L+            G G WS  D +  Q++QVDL  RK I AIA QGR  S+++ K Y + +S  D    W+ +R   G  + F GN N        L Y +VAR++R  P  W++     +R E++GC Y      FDG+  + YR     + ++   D I  RFKTS  +G++++ EG Q DYIT+E+ R++L +++NLG+    + +   ++  +GS+LDD+ WH V I R  + +N TLD+         +F HL+L+  IS GG+   + K      QNF+GC+E ++++G  I    RR+
Sbjct:   70 SAFSSSSVLAPDFGAGYAKLNRR---------VGNGGWSPLDSDRYQWLQVDLRGRKQIMAIATQGRYSSSDWTKQYRILYS--DTASNWRPYRQD-GNIWTFSGNWNSERAVRHELQYTVVARYLRFIPLEWSEEGRTGLRVEVYGCAYWADVISFDGQGVIPYRFRH--KKMKILKDVISLRFKTSKGDGVLIHGEGQQGDYITLELRRAKLVLQINLGSNQYGSIQGHTSV-SSGSLLDDDHWHSVLIERYRRSVNFTLDQQTQSFRTNGEFGHLDLDYEISFGGM-PLSAKPISGGPQNFVGCMEGILYNGDNITNLVRRR 378          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGG------GRAAVS---SFQGCLRNIYINN-----VQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN-NLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQNP--CLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD--YSDQKISTLE------------EYIEIGFKTKDKQGTLLQVSSNDF-KKYIIIKVNNNGGITIEFDVGFTRY-EVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVD-DYRIIKKSFISILSANSDARLDKPT-YVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLK--MLFNDEPLPNVRVSGTGIRENNCG 3805
            G+  +DG+WH V L     ++T+  D    ++ Q    ++     +Y GG      G   ++   +FQGC+R I INN     +QV        + ++   C + D C+PN C++   CTQ   +F C+C+ TGYSG  CH S   +SC   + R AG  SS   ++D DGSG L P QV C+ +   + T ++HHN+   V V              Y ++    L  LV  S YC+Q ++Y+C  ++L     G           WW+ R G+   YWGG +PG+Q+C C ++  C   +  CNCD D   + + + D+G+L+ K DLPV+ + +GDT        ++ +VGPL C+GD    N+ +F +  S L+ P    E  FD+ F FKT   + V L+++  Q+  F  V +    T+  +FN G G  ++ V     LND  WH VR ERN KE+ L +D+  P+   E P   +     +S+L VG + S   G++GC   L VNGV  DL        G+S GC   C+ +   C NRG+C E  SGY C+C  + Y G  C  EV  SF  GS+V  T    +S  +  T +            + + + F T      LL V  N F ++Y+ I +  NG + I + +   R   V +  + +L +   H L+  R   G+   +QVD D++    S+ +  ++     L K      +    +Q    GF GC   +Q+N+I PLK  +L     L N+R     + E+NCG
Sbjct:  448 GQRVNDGLWHLVSLSTRDLQMTMTLDNEPASSIQ-LEDNLEPRDSYYFGGCPLSQNGSGCMNPSMAFQGCMRLILINNQPTDLMQVQQGMLGSWNQLQFDICGIQDRCLPNFCENGGRCTQTWSSFQCDCAGTGYSGATCHNSVYESSCE--AYRLAG-SSSGDFSIDPDGSGPLGPIQVYCNVTEGKVWT-VLHHNSTGSVRVRDSTLEKPHSTHFNYGSSPAQ-LRALVSESEYCQQRVTYQCRRSRLFNTWDG-------VPLSWWLDRSGERRTYWGGFLPGVQQCACSLEENCIDMNYFCNCDAD---RDSWENDTGLLSYKDDLPVSGISIGDTNRL--NSEAVYSVGPLECSGDKSLWNSASFYEEASYLHFPAFQIEFSFDISFYFKTGSPSGVFLENLGLQD--FIRVELSSPSTVTFSFNAGDGPVVLAVKSPVPLNDRQWHWVRAERNVKEASLQVDQ-LPLRFLEAPPNGHLRLQLNSQLFVGGTASRQRGFLGCIRALDVNGVNFDLDERAKMTPGVSSGCPGHCSSSAGLCHNRGKCIEKSSGYICDCTHSAYGGPSCKEEVSVSFEKGSSVTYTFQEPFSVMQNRTAQVSSSSSTYSKSRDNMALSFLTTQSPAMLLTV--NTFTQQYVAITLARNGSLQIWYRLNKERRPSVFSPVLTNLADGILHRLRLHRE--GKDVYVQVDQDHKRYSLSYDAEFNSMRSLTLGKVAGNEALDEEVAQAGSRGFVGCFSSVQYNHIAPLKAALLNRGSSLVNIR---GHLLESNCG 1204          

Query:  144 NGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFR--DPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDA-RRKVNMAANGN 1151
            +G+  +  +SSS FS   A  +ARL+  D         G G WS +  +   ++Q+DL ERK +TA+A QGR GS+++V  Y + +S  D   +WK +R  D  G+     GN N ++V    L+  I  R +R  P  WN    + +R E +GC+YK + A FDG+S ++YR +Q  +++ T  D I  RFK+    G++L+ EG + DYIT+E+ R RL + +NL     V   S   ++  GS+LDD  WH V I R  K +N TLDR         D   L ++  +S GG+    GK G  + +NF GC+E + ++G+ II  A RRK  + + GN
Sbjct:   36 SGLPAASFQSSSHFSESRAAYFARLNRRD---------GGGGWSPQLTDRAPWLQLDLRERKEVTAVATQGRYGSHDWVSAYMLLYS--DTGRVWKQYRHEDSVGK---LVGNLNPDSVVHQKLSQSIRTRFLRFVPLEWNPSGRVGMRIEAYGCVYKSYVADFDGRSSLLYRFNQ--KSMSTVKDVISLRFKSRQAEGVLLHGEGQRGDYITLELHRGRLALHLNLD-DTRVRSSSGRMVVTLGSLLDDQHWHSVLIERFNKQVNFTLDRHTQHFRAKGDGDSLEVDYELSFGGI-PLPGKPGTFLRRNFHGCVENLYYNGVNIIDLAKRRKPQIYSVGN 358          

Query: 1556 ADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTK-DISLGKDFYIGG------GRAAVSSFQGCLRNIYINN-----VQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSD--QKISTLEEY-------IEIGFKTKD--------KQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDY-IVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNF----------SQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXX---XXXXXXXXFNITTDIPDW-QRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAI---RYGKTNQPDVAGKEWW 4108
            A G   +DG WH V     +N   +  D    +  +  T   I+ G  ++ GG         +  SFQGC++ I +++       V         ++    C++ID C+PN C+H   CTQ   +F+C+C  TGY+G  CH S    SC   + +  G +SS    +D DGSG L PF+V C+ +   + TT+ + N      V G        L L Y +A  + ++ +   + +CEQ ++Y C  ++LL  P G         + WWVGR  +  FYWGG  PGIQKC CGI+  C+     CNCD D   Q   Q DSG+L  K  LPV++V +GDT     G  + + VGPLRC GD  + N  +F+   S L+      E   D+ F FKT+    V L+++   N  F  + ++    +  +F++G G +E+       LND+ WH V  ERN KE+ L +D+      +  P + +T     S+L VG++     G++GC  +L +N V  DL+       G+  GC+  CT     C N G+C E Y+GY C+C  T Y G  C ++VG  F  G+ +   L  SD     S++E         +E     +D           ++L   S+  + Y+ + +  NG + + +++G  R   T D    +L N Q H++   R  + +   +Q+D Y  +  +    L   SD + +    +++G+ F           + +  GF GC+ R+QFN+I PLK   +      V   G  + E+NCG   +                P  PFN    IPD   R   I+G I+AV+   IL  L+F  R     +G Y T EAKG +  ++AD AI       T   D + KEW+
Sbjct:  384 ASGSGLNDGEWHDVRFLAKENFAMLTVDGDEASAVRTNTPIQITTGGTYHFGGYFLRTQASPSQRSFQGCMQLIQVDDQLADLTAVEQGRLGAFENVSLDMCAIIDRCMPNHCEHGGRCTQTWNSFSCSCDGTGYTGATCHTSVYEQSCE--AYKHVG-RSSDLYWIDPDGSGPLGPFKVICNMTEDKVWTTVAN-NLPAQTSVTGSSRERRTVLQLNY-SATMEQISAITSSAEHCEQHVAYNCRMSRLLNTPDG-------TPYTWWVGRGNEKHFYWGGSAPGIQKCSCGIERNCTDPKYHCNCDAD---QKQWQEDSGLLVYKDHLPVSQVAVGDTNRP--GSEAKLTVGPLRCQGDRSYWNAASFNTPSSYLHFSTFQGETSADISFYFKTSAPYGVFLENLG--NTDFIRLELKSPTVVSFSFDVGNGPVELNVHSPTPLNDDQWHRVSAERNVKEAILQLDQQYKEV-RPAPAQGHTRLELYSQLYVGAAGG-QRGFLGCIRSLKMNAVTLDLEERAKVTPGVKPGCSGHCTSFGMYCRNGGKCVEKYNGYSCDCSATAYDGPFCTKDVGGFFEAGTLIRYNL-VSDVVAAASSVEGKSVGTSLPMETNLTREDVAFSFSTSSTPSILFYISSKTQDYMAVVLRQNGTLQLRYNLGGLREPFTIDLDQRNLANGQPHSVNITR--IERDIYVQLDHYPSVSYT----LPEASDTQFNLVKTLFLGKVFETGQIDPVLIEKYNTPGFVGCLSRVQFNSIAPLKAALSTRASAPVSHQGK-LVESNCGASPLTIPPMSAATDPWNQKDPDFPFNEERVIPDGVNRNSAIIGGIIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGGESSESADTAIIGTDPNFTETIDESKKEWF 1255          

Query:  171 SSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            SSS F+   A  YA+L+            GAG WS  D +  Q++QVDL  RK +TAIA QGR  S+++   Y + +S  D    WK +    G  + F GNSN  +V   +L + IVA+++RI P  W++   I +R E++GC Y      FDG+  + YR     + ++   D I  +FKT             Q DYIT+E+ R RL +++NLG+    +     ++  +GS+LDD+ WH V I R  +++N TLD+         +F HL+L+  +S GG+  ++GK      +NF GC+E + ++G  I   ARRK
Sbjct:    1 SSSVFTSGYAPGYAKLNRRG---------GAGGWSPLDSDHYQWLQVDLGSRKQVTAIATQGRYSSSDWTTRYRLLYS--DTGRNWKPYHQD-GNIWAFTGNSNTESVVRHDLQHAIVAQYLRIIPLDWSEEGRIGLRLEIYGCPYWADVINFDGQGVISYRFKM--KKMKILKDVIALKFKT-------------QGDYITLELRRGRLLLQINLGSNQYGSILGHTSVT-SGSLLDDHHWHSVVIERYRRNVNFTLDQHTQHFRTNGEFDHLDLDYELSFGGM-PYSGKPISGGRRNFKGCMESINYNGENITDLARRK 292          

Query: 1547 DLTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYDP------KNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYN-TADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLD--------------YSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTR-YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQV-----DDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCG 3805
            D+TA G + +DG WHSVEL + + +L + AD+   +T                 G R   S FQGC+R I+++   V+          NF S ++   C ++D C P+ C+H   CTQ   TF CNCS TGY G  CH S    SC     R     +S    +D+DGSG + P  + C+ S  +    ++ HNN +  L +     G+ +    +N +AD   L  ++ R+ +CEQ +SY C  ++LL  P G         F WWVGR G+   YWGG +P  Q+C CG+Q  C      CNCDGD+                 D     +              I+N           F N   F+K  S L+ P    E   D+ FLFKT  S+ V L+++  ++  F  + +     +  +F++G G  E+       LND  WH V+ ERN KE+ L +D N P   Q+ P   +     +S+L VG + S   G++GC  +L +NG   DL+        +  GC   C      C NRG C E Y+G+ C+CG +PY G  C +EV A F  G++V  T                     ++   E + + F+T      LL VSS  +++Y+ + +N NG + +++ +   R  EV      +L N Q H +   R  + ++ ++QV       Y  +K  F++         +D           ++++ LGFTGC+  +QFN+I PLK          V V+G  + E+NCG
Sbjct:  376 DITA-GSALNDGQWHSVELSVRRGRLILAADKADTSTTT-------------TSGCRNLFSVFQGCMRLIHLDGSLVDLIKVQQMLIGNF-SGLQMDLCGIVDRCSPSHCEHGGKCTQSWSTFHCNCSNTGYGGATCHSSVYEASCEAYKHR---GNTSGLYYIDVDGSGPIKPQLIYCNMS--DKAWMVIQHNNTE--LTKLRASSGTNQHLAYFNYSADTKQLGAIISRAEHCEQELSYHCKKSRLLNTPDGA-------PFTWWVGRSGEAHTYWGGAVPDSQQCACGLQEDCVDPEHFCNCDGDL-----------------DDWYPTLYPPYLPYPPYPPKGILNGPSEHLLSSDDFWNAAYFNKETSYLHFPTFHGELSADISFLFKTRSSSGVFLENLGIKD--FIRIELSSPTEVIFSFDVGNGPFEVRVETPEPLNDERWHRVKAERNVKEASLHVD-NYPGAVQKAPADGHIHLQLNSQLFVGGTASRQKGFLGCIRSLKLNGKTLDLEERAKITPEVRPGCPGHCRSYGGLCQNRGRCVEKYNGFACDCGASPYSGTFCHKEVSAYFRPGTSVAYTFKEPYELNRNSSSQSSSIYSDLTLKGENVSLSFRTGQAPALLLYVSSY-YREYLAVLLNRNGHLDVKYKLQSNRDAEVFRSNARNLANGQLHQVSIRR--VSESLSVQVRCTLHTLYEDMKAVFLTGAEGAESGEMDP--------EIARLNALGFTGCLSVVQFNSIAPLKAALLYPDTSPVIVTGP-LTESNCG 1097          

Query:  144 NGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFR--DPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK--VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNR-NIS 1007
            + +  S  +SSS  S      YA+L+  D         GAG WS  D N  Q++++DL +R  ITA+A QGR GS+++V  Y + FS  D    W+ +R  D  G    F GN+N ++V    L  P+ A+ +R+ P  WN    + +R E +GC YK   A FDG S +++  D P     +  D +   FK+ + +G++++ E      +T+E+ + +L + +  G   +            GS+LDD  WH + I R    +N T+D+      L     H  +N+ N+S
Sbjct:   25 SSLPQSAFRSSSQLSNSHGPGYAKLNRRD---------GAGGWSPLDSNKYQWLEIDLEQRTEITAVATQGRYGSSDWVTSYLLMFS--DTGHNWRQYRQEDSIGA---FSGNTNADSVVTYKLQQPVFAQFLRVLPLDWNPNGRVGLRLEAYGCQYKSDVASFDGTSYLLFSFDPPPGP--SAKDLLTANFKSVHHSGILIHMEDQHGHALTMELLKGKLFLHLRKGTAGD-----FHTTASLGSLLDDQHWHHISIERLRGHVNFTVDKNTQRLQLPEHQSHFQINQGNVS 296          

Query: 1508 DGVLPIAYSIPNPDLT--ADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQ-YFTKDISLGKDFYIGGG---------RAAVSSFQGCLRNIYINNVQVNYDP------KNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKS-AITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIE--------------IGFKTKDKQGTLLQVSSNDF-KKYIIIKVNNNGGITIEF-DVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDY-----RIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTG 3784
            DG L +    P  D    + G   +DG WHSV + L +N + V  D    +  Q Y   DI  G  +Y+GG          RA   SF GCLR+I I    ++          NF  +  N TC ++D C+PN C+H   C+Q+  +F C+C  TGY G  CH      SC E      G  +S    +DLDGSG L P  V C+ +   + T + H +   +  V G     +F    VYN A  + L+ LV ++  C Q ++Y C  ++LL  P G         F WWV R  +   YWGG  PG+QKC CG++  C+     CNCD D   +     DSG LT+K  LPVT++ +GD        S +  VGPLRC GD  F N  +FS   + L  P    E   D+ F FKT       L+++  Q+  F  + ++    + + F++G G +E+I V    LND+ WH V  ERN K + L +DE  P   +  P   +T    +S+L VG++ S   G++GC   L +NGV   L+  A T   G++ GC   C+   + C N G C E YSGY C+C  TP+ G  C +EVGA F  G+ V+ +LD   ++ S  E+  E                F T      LL  S++ +   Y+ I + +NG + + F   G +     +  + +L + Q H +   R   G    +Q+D Y     R+         +A++      P  V +    + ++  GF GC+ R+Q+N   PLK      P  ++ V+  G
Sbjct:  181 DGRLTVTLLQPGRDALHLSAGSDLNDGQWHSVSVSLRRNFVGVTLDGDEASAIQSYNPLDILTGDVYYLGGCPAVAAPGQCRAPHGSFLGCLRSIRIAEQDLDMGLVEQGMLGNFTGAQLN-TCGILDRCLPNHCEHGGQCSQEWDSFFCDCDGTGYLGDTCHNPVFERSC-EAYKHLGG--TSGFYHIDLDGSGPLGPLLVYCNVTEERVWTVLAH-DGTDERRVPGTSTALAFVARFVYN-ASSEQLSALVEQAEQCRQEVAYYCRRSRLLNSPDG-------PPFTWWVSRTNERQHYWGGSSPGVQKCACGVERNCTEEHVHCNCDAD---RDEWMHDSGWLTNKEHLPVTQLVIGDANRSRSAASYL--VGPLRCHGDKHFWNAASFSNRTAYLLFPTFRGEKSADISFYFKTVAPFGTFLENLGLQH--FLRLELKSPLEVSLRFDVGDGPVELIAVSPWPLNDDQWHRVCAERNVKRASLQVDE-LPRRVRRSPPDGHTRLRLNSQLFVGATASGKRGFLGCLRALQMNGVTLSLEERARTAVGGVNPGCTGHCSSYGSLCRNGGRCVERYSGYSCDCTHTPFDGPFCTQEVGAYFEAGTVVQFSLDSESREQSIEEDEDEQAEEEDDLDEERAIFSFSTVHAPAVLLHASTHAYPSSYLAIVLEHNGSLQLWFGGSGTSSPRTVSAGMRNLADGQVHAVNMTRR--GTLILLQLDHYLPTAHRLPTGHAPYPRAADTLYLGRVPDEVPLEPEVAGLNWRGFGGCLSRVQYNGWAPLKAALRQGPHSSLVVTVMG 959          

Query:  813 GAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGNVGSDCPPPSSFQNVITFPSIDSN-GIYGKVTIEGLSSISFKVTFRTFAVNGMLFYHVVDLMFTQFISLSI 1469
            G++   AP    ++   G++LDD  WH V + R  + +N+TLD          DF +L+L+  +S GGL    GK   S  +NF GC+E + ++G+ +I  A+R+           +  +Y                         I GNV   C  P      ITFP   S+  ++G    E LS +   +  RT++  G L Y        +  SLSI
Sbjct:    1 GSRQQRAPTGHTSV-TVGTLLDDQHWHSVSLHRHGRHVNLTLDGHTRHLRTNGDFDYLDLDYQLSFGGLST-PGKGRSSFKRNFQGCLENVSYNGVNLIDLAKRR-----------KPAVY-------------------------ITGNVSFACAEPRVVP--ITFPLPGSSLWLWGPAWHEALSVV---LELRTWSARGTLVYTAFSPAGPRASSLSI 177          

Query: 1556 ADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTK-DISLGKDFYIGGGRA----------AVSSFQGCLRNIYINNVQVNYDPKNFD-----SSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLE-------------EYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQV 3559
            + G+  ++G WH+  +   +  LT+V D       +      ++ G  +Y GG  +          ++  F GC+R I I++  V+            +++    C + D C+P+ C++   C+Q  R+F CNC+ TGY+G  CH     +SC   + +  G  S +   VD DGSG L    V C+ +   + TT+ H+N E+   V G   P    L     +A  + L  L+  + +C+Q ++Y C  ++LL  P G       + + WWVGR  +   YWGG IPG+QKC CGI   CS     CNCD D+      + DSG+L  K  LPV ++ +GDT   +    +   VGPL C GD  F N++ F+   S L+ PP+ AE   D+ F FKTT  + VIL+++   +  F  V+++    +  +F++G G +E+       LND  WHVV  ER+ KE+ L +D   P      P + +T+    S+L VGSS S   G++GC  +L +NG   DL+       G+  GC+  C    + C N G C E Y+GY C+C  + Y G  C  EVG  F  G+ ++  L   D     +              E + + F T      LL V ++ + +Y  + +  +G + I + +G     +  +   +L N Q H L   R   G+  ++QV
Sbjct:  377 SSGKQLNNGEWHTASVQARERTLTLVVDGAEDTAVRSLLPFHVATGSIYYFGGADSRLTFSKNLIRSLPPFLGCMRLINIDDHLVDLSLLQQGLLGNYTNLMLDQCGLTDRCLPSHCENGGTCSQTWRSFECNCAGTGYTGVTCHAPIYESSCE--AYKHLGRASGR-YWVDPDGSGPLRAMHVYCNMTEDKVWTTVDHNNTER-TWVRGS-SPERPILAAFAYSASAEQLAALISSAEHCQQEVAYYCKRSRLLNAPDG-------EPYTWWVGRTNEKQRYWGGSIPGVQKCACGITENCSDPKFHCNCDTDM---EHWKEDSGLLGYKPHLPVMQLLIGDTDRAL--SEAAYKVGPLSCHGDRHFWNSVLFTTPSSYLHFPPIRAETSLDIAFFFKTTTDSGVILENMGASD--FIRVQLKSPHEVSFSFDVGNGPVEMAVRSEQPLNDEEWHVVSVERSLKEASLRVDL-LPRELVPAPAQGHTSLQLSSQLYVGSSVSGHSGFLGCVRSLRINGATLDLEERARVTPGVKPGCSGHCRSYGSLCRNGGRCIERYNGYSCDCSTSSYNGPSCTNEVGGFFELGTWIQYDLLEDDDDEEAVAAAIREPLEDSLPGETVLLSFSTTSVPAILLYVGTDSW-EYFAVLLQEDGRLQIRYQLGGETEAIYME-PRNLANGQPHGLNVTRH--GREISVQV 1052          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWN--KVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARR---KVNMAAN 1145
            GAG WS   ++   ++Q++L  R  +TA+A QGR GS+++V  Y + +  GD    W+ +++  G  ++F GN N + V    L +PIVAR++R  P  WN  + + +R E++GC YK     FDG+S + YR +Q  R  +TR D +  RF+++   G++L+ EG + D +T+E+ R  L + ++L    +V  +       AGS+LDD  WHDV + R+ +  N+T+DR     ++  D   L+L+  +  GGL  F GK G     NF+GC+E + + G Y+   A+R   +++M+ N
Sbjct:    1 GAGGWSPGRVDRGPWLQLELPGRVEVTALATQGRYGSSDWVPRYLLLY--GDSAGNWRQYQED-GNAWVFPGNENSDEVVRHELQHPIVARYLRYVPLDWNAYRWVGLRVEVYGCPYKSEAVFFDGRSLLAYRFEQKTR--RTRKDVVSLRFRSALSEGVLLHGEGQRGDTLTLELQRGCLHLLISLD---DVRSQVAYTSASAGSLLDDQHWHDVMLVRSGRHGNLTVDRHTQRFHVKGDDDSLDLDYQLMFGGL-PFGGKAGSVGRPNFLGCLENVYYSGEYVTDLAQRIKPQIHMSGN 292          

Query: 2609 FDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEI-----------------TLDY---SDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFD-VGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSF 3589
            F N  +FS H S L+ PP+ AE   D+ FLFKT+  + V L+++   +  F  V+++  + +   F++G G +E++      LND  WH V  ER+ KE+ + +D   P      P R +     +S+L +GSS S   G++GC  +L VN V+ DL+       G++ GC+  C      C N G C E   GY C+C  +PY G  C  EVG  F  G+ V+                  TL +   SD  +S   E   +GF T+     LL VSS      + + + +NG + I +   G  R +V       + + Q H+L   R D      IQ+D Y  +K+  
Sbjct:    2 FWNAASFSTHRSYLHFPPVHAETSLDITFLFKTSAESGVFLENMGTHD--FIRVQLKSPYEVSFGFDVGNGPVEMVVRSGQPLNDEEWHAVSVERSLKEASVRVDR-LPREVAWVPSRGHAHLQLNSQLYIGSSVSGDSGFLGCVRSLRVNSVMLDLEEQARVTPGVNPGCSGHCRSYGALCRNGGRCVEHSVGYSCDCSSSPYDGPFCTTEVGGFFERGTWVKYEFQDPHKLLASTRSDKDTLPFERASDMPVSESGEMALLGFSTRTAPAMLLHVSSKS-GSCLTVTLQSNGSLQIRYSRKGGQRIKVIHPDPRSMADGQPHSLNITRQD--SFVYIQLDHYPQVKRHL 346          

Query:  693 IKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVK---MWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAAN 1145
            I F FKTS  +G+ L   G   D+I +++   +    ++ G  V   P  M  ++ +G  L+D +WH V + R+ K+ +V +DR+     W   +    HL LN  + +G   + +G  G      F+GC+  +  + + +  + + +V    N
Sbjct:   28 ITFLFKTSAESGVFLENMGTH-DFIRVQL---KSPYEVSFGFDVGNGPVEM--VVRSGQPLNDEEWHAVSVERSLKEASVRVDRLPREVAWVP-SRGHAHLQLNSQLYIG--SSVSGDSG------FLGCVRSLRVNSVMLDLEEQARVTPGVN 166          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTK---DISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVC 1939
            G+  +D  WH+V +  +  + +V  D++        ++    + L    YIG   +  S F GC+R++ +N+V ++ + +   +   N  CS         C++   C +    ++C+CS + Y G  C
Sbjct:   79 GQPLNDEEWHAVSVERSLKEASVRVDRLPREVAWVPSRGHAHLQLNSQLYIGSSVSGDSGFLGCVRSLRVNSVMLDLEEQARVTPGVNPGCSGHCRSYGALCRNGGRCVEHSVGYSCDCSSSPYDGPFC 207          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGG-------RAAVSSFQGCLRNIYINN--VQVNYDPKNFDSSIRN---GTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDG 2446
            G S +DG WH V L    + L V+ D   +         +  G  +Y GG        ++AV+ F GC+R I+++N  V +    +    +  N     C + D C+PN C+H   C Q    F+C+C  T Y+G  CH      SC   + +  G ++S    VD DGSG L    V C+ +   + TT+ H N EK V V+G      F +   Y  A  + L  +V  + +C+Q ++Y C  ++L   P G       +   WWVG+  +   YW G +P +QKC CGI   CS     CNCDG
Sbjct:  327 GSSLNDGEWHGVTLQARDDSLLVMVDGREHFVMLSPVLHLIAGNAYYFGGTNTTPGHPQSAVAPFLGCMRLIHMDNQPVDITLLQQGLLGTFINVHFDLCGLTDRCLPNHCEHGGRCMQTWGGFSCDCQGTSYTGSTCHTPAYELSCE--AYKHLG-RASGHYWVDPDGSGPLGALLVFCNMTEDKVWTTVTHENMEKTV-VQGASVTQPFLVMFTYG-ATAEQLAAIVASAEHCQQEVAYYCKRSRLFNAPDG-------EPHTWWVGQTHEKQRYWSGAVPRVQKCACGITKNCSDPKFVCNCDG 621          

Query:  465 FFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNI-LDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARR-KVNMAANGN 1151
            F GN N + V   +L   IV R +R  P  WN    I +R EL+GC Y+   A FDG+S + YR +   R  +TR D +  R +T   +G++L+ EG +   +T+++ R RL + +  G + + A E M  I + AGS+LDD  WHDV I R+ +  N+T+DR      +  D+  L+L+  +S GGL  F GK G     NF+GC+E + ++G  +   ARR K  +   GN
Sbjct:    1 FPGNKNSDKVVRHDLQNSIVTRFLRFMPIEWNPEGHIGLRVELYGCPYRSSVAYFDGRSLLAYRFEHKVR--RTRKDVVSLRMRTKRSDGVLLHGEGQRGGGLTLQIHRGRLNLHLRFGMEGD-AGEGMGYITVSAGSLLDDQHWHDVTITRSGRHGNLTVDRHMQRFQVMGDYESLDLDYQLSFGGL-PFGGKPGNRAHPNFLGCMENVYYNGEDVTDLARRAKPQIHITGN 229          

Query: 2144 DPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTG 2599
            + G +R  + Y+ A    +  LV  S+ CEQ +   C + + L    G G       +GWWV   G+ +F+WGG  PG  KC CG+  +C      CNCD +       + D G+LT ++ LP+  + LGD T     + +   +G LRC G
Sbjct:    3 EAGCYRRDVRYD-AKFHQIRALVAVSSDCEQHVKLHCRHIRFL----GAG-------WGWWVSWDGRRMFHWGGAEPGSGKCACGMTDSCYAPGKPCNCDAN---DHIWRGDEGLLTSRAALPLRALHLGD-TRDAPLEMAYHTIGKLRCRG 138          

Query: 1580 GMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYDPKNFDSS--IRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNE-----KDVLVEG------------HLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQ-KCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGML--TDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEF-----DMIFLFKTTVSNAVILQSVSK--QNQQFFEVRIREGFTLRVTFNLGYGIE--IIEVVVNNLNDN-FWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGS-SQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKC-TQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFD--VGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNN----------IFPLKMLFNDEPLPNVRVSGTGIRENNCGQ 3808
            GMWH VE  +    + +  D++             L ++F+IG  +     F GC+ NI +N V+  +DPK+   +  I  GTC + D C P  C+H + C QDG+TF C+C  T Y G VC  SQ   +C E+ L +  +++    T+D DGSG   P+Q  C     NITT +    +E      +VL E                P S    ++Y      A   +   S YC+Q + Y C  ++LL        N  N A+G WVG  G+  +YWGG  P    KC CG++G C  N G CNCD     ++T ++D G L  ++   LPV++V  GD     +  ++   VGPL C G    +NT TFS+ D ++ L   + E        D+   F+T  +  ++     K    + F +V I    T+++++++G G +  +++V  N LN N  WH V    N KE  L +D    +  + +P +     +    L +G   +   +G+VGC     +NG + +L     D   ++ GC   C  +  C     C + Y+ Y C+C LTP+ GY C +++GA+F +  +  +   + + +         +GFKT    GT+++++S+    Y  I + ++  +  +++   G    E+        C+++ HT    R          +  YR+     +           ++P  + +G       +  F GCI  ++  N          I P+K L  D    N  +   G+ ++ CGQ
Sbjct:  329 GMWHHVEFEIGPIAVWINVDKMV----DMRPPSADLPQNFFIGSVQIG-GDFVGCVLNIELNGVK--FDPKSLSPTEYIEVGTCHITDFCFPTVCQHGSKCIQDGKTFGCDCLNTHYKGSVCQFSQYYRTCYELQLEYPELETG-NYTIDPDGSGPEEPYQTIC-----NITTELDWFGDEISRVWTEVLTEDWNVLLQKYPPEEAQKPESVIRDIMYKPTFLSA-QMVAMASEYCKQFVEYLCTGSRLL--------NSLNPAYGHWVGSHGRHYYYWGGSGPQYPGKCACGVRGDCLDNKG-CNCDA---RRSTLESDEGYLFGSNGQILPVSQVLFGDVDIDSDHYAN-YTVGPLLCYGRP--NNTATFSREDGIISL--RYREGSLDGEYGDVSLFFRTPYTRGILFHQGEKTRNTRDFIQVNITSNDTVQLSYDIGNGPQSIVVQVTENPLNTNRLWHKVVVWFNIKEFGLEVDGIRKI--RLNPLQQSKQLDVVGNLFIGGYMREMMNGFVGCIRGFTINGEVLNLARLSKDFDYVNEGCYSACNNETQCKGGARCTDDYNIYKCDCHLTPFYGYFCEQDLGAAFKETDSY-LRYTFPEGERDAWGTDFAVGFKTGQCSGTIMEMTSHTQGHYFRISIQDDNKLIFKYNTAAGDGGKEILPPKGKSFCDNERHTFSMERKK-------DLLIYRVDGGPEMRDSGERLTKPFERPKQLLIG----ATGEGRFEGCISGVKITNWPTEKIMGPTIEPIKQLLYDNDDTN--IVAKGVSKSKCGQ 1070          

Query:  621 FDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILY--AEGDQF-DYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVK---MWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIR 1112
            FDG +   Y L      I +  + I+ +F+T   NGL+L+  + G+++ DY TIE+   +LR  ++LG +  +  + M N +  G  L DN++H V I    +++ + LD++      R + + +  L L+    +GG  +    R +    NF GC++ +  +G  I++
Sbjct:   58 FDGNAYAEYLLHDQDEKIDSPKNTIELQFRTIQPNGLLLHGSSSGEEYGDYFTIELIGGKLRFAISLGRRQGI--DDMVN-MTLGDGLADNKFHTVLIEHNNREVWLFLDQLTRDDKRRRIETRYKQLTLDEFFFIGGAHDMKRIRDVISGANFQGCLKGVRVNGKNILQ 224          

Query: 1475 ITGYLTVEVTLDGVLPIAYSIPNPDLTADGRSFSDGMWHSVELYLTKNKLTV-VADQVTYNTFQYFTKDI-SLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRN---GTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCD-GDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTG 2599
            +   L +E+ +    PI  S+        G + +DG+WH V   + + +L + + D+        + K+I    +  YIG G    + F GC+ NI +N   V   P+     +     G CS+   C PNPC++   C +   ++TC+C  T Y G  C      ++C E   +  G+       VD DG G L  F+V C+ +     T + H+   +  + +   +   F    +    D  ++  L+ +S  C Q IS+ CFN  +L  P G        A   W+ R G    YWGG     Q C CG+ GTC+  +  CNCD GD    +  + D+G L DK+ LPV+ ++  +  ++     S   +GPL C G
Sbjct:  170 VHAKLELEIRIGTDRPIKISL--------GENLNDGLWHDVTSGINRKELWLTLDDKPEVRHANPWLKNIGKFRRRTYIGSGTQK-TGFVGCMNNIKLNGALVR--PRKLSKEVAGAVIGRCSITSKCFPNPCQNGGACKESWDSYTCDCQGTFYEGATCEVPLYRSTCEE--YKTLGISEDSYCKVDPDGKGPLGSFEVMCNMTNPEAKTVVSHNKQMRQEVTQDASNFHGFYFHHINYQHDLASIRALIVKSKRCRQYISFNCFNTLILNAPNG-------PAHAQWLSRTGVLQNYWGGAPADRQICACGVDGTCADPTKYCNCDIGD----SVWREDAGYLRDKNALPVSMLQFTEDASR-----SYFTLGPLECFG 521          

Query: 2684 DMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPY--TTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIG---CNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVC 3226
            D +  FK +    V L  V  +     E+ IR G    +  +LG           NLND  WH V    NRKE  L +D+   V H      P+      F     +GS    T G+VGC +N+ +NG +   +    +  G  IG      KC  NPC N G C E +  Y C+C  T Y G  C
Sbjct:  152 DGVLAFKMSTDARVYLSLVHAK----LELEIRIGTDRPIKISLG----------ENLNDGLWHDVTSGINRKELWLTLDDKPEVRHAN----PWLKNIGKFRRRTYIGSGTQKT-GFVGCMNNIKLNGALVRPRKLSKEVAGAVIGRCSITSKCFPNPCQNGGACKESWDSYTCDCQGTFYEGATC 318          

Query:  864 GSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGL-----GNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKV 1130
            G  LDDN+WH V++ R ++ L +TLD  +   N    F+ L+L++ I VGG+      ++ G R      NF GC++++ FD + I+  A+ ++
Sbjct:   10 GENLDDNKWHTVKVARNQRSLLLTLDNKETRTNTAGSFVRLDLDKFIFVGGVDRSLPDDYHGARD---APNFKGCLKDVYFDFIDILYGAQYEL 100          

Query: 1562 GRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTK---DISLGKDFYIGGGRAA----VSSFQGCLRNIYINNVQV---NYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVE-GHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGT---CSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTG 2599
            G + +DG WHSV   +    + +  D  T + F   T    D S      I  GR A       F GC+ N+ I++ ++   +   + + + I    C+  + C PNPC +   C QD ++F C+CS T + G+ C       +C     +  G++      +D D  G    +   C+ +  + + T++ HN E  V V+ G      +   + YN      +  L+R+S  C Q I + C  +KLL  P G      + AF W   +  +   YWGG IPG   C CG +GT   C   S  CNCD         +TD G  T+K  LPVTE++  + + +     S   +G L C G
Sbjct:  287 GENLNDGEWHSVNASIVPPNVQLTLDDRTRSKFLNLTSLLLDFSNKSRLKIFAGRGAREYKFPGFVGCMLNLRIDSHKITARHLSKQKYSNGIDATKCATSNRCFPNPCINRGTCWQDWQSFYCDCSNTYFEGKRCELPIYKPTCEH--YKSLGLKRDAHCLLDSDEDGPEGEYTALCNVTDPSRSYTVLQHNKETRVAVDSGSRINRQYIHKITYNAVSEAQITALIRQSKKCRQLIRFDCIKSKLLNSPSGP-----SHAF-WRPFKSNKLQSYWGGAIPGSGACACGNKGTPSSCDNPSKLCNCD---IRDNEWRTDEGYFTNKELLPVTELQFHEKSAR-----SYFTLGALECWG 630          

Query:  558 NKVISVRFELFGCIYKPWTAQFD--GKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNI-LDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLG-NFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMA 1139
            +++    F L+  ++   T +    G   + Y + +P   I+++ + + FRFKT + +GL++Y+ G  +DYI +E+ +  L        K    P  +D   +  G  L + +WH V + R  +   +++D +   +     + HLNL+  I +GGL  N   K  I  + N+ GC+ ++VFD   ++  A++ +  A
Sbjct:    3 HRITLCSFCLYAQVFCVLTTEITLRGSQYISYNI-KPSE-IRSKKNILSFRFKTIHPSGLLIYSRGSTWDYIQLELIQGAL--------KYTAYPGGVDKTEIQLGKDLFNGKWHTVSVNRNGRLTMLSVDDLSTTKITPGPYDHLNLDGLIFIGGLSVNTKNKVRIKAL-NYRGCLSDIVFDRANLLDGAQKALGPA 189          

Query: 2084 ITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRC 2593
            I  T+V H++E    V G+ DPGS+   + YN      L EL  RS YCEQ I Y+C  + L   PGG         F WWV R G  +  WGG   G  KC CG+ GTC+  +  CNC  +     T + DSG+LTDK  LPV ++R GDT    E     I +G L C
Sbjct:    6 IGVTVVGHDSEARTHVNGYKDPGSYSRDITYNFTSVTQLKELTTRSNYCEQFIKYECKGSSLYYYPGG-------NWFNWWVSRDGHKMTSWGGAPTGSNKCACGVTGTCANPAYRCNCSSN---DGTWREDSGLLTDKDTLPVIQLRAGDTDASTE--DGYITLGKLMC 163          

Query: 2000 SSKTVTVDLDGSGALTPFQVDCDFS-VFNITTTIVHHNNEKDVLVEGHLD--PGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTG 2599
            SS T ++D DG G  + F V CD +    +  T++ HN+E    V   +   PGS+  P+ Y  A+ + L +L   ST CEQ I ++C++   ++             + WW+ R    + YWGG  PG  KC CG+  +C+  S  CNCD +     T ++D G+LTDK+ LPV E+R GD  +  E  +    +G L+C G
Sbjct:    3 SSGTYSIDPDGPGGESAFNVYCDMTDKGGVGVTVISHNSESRTYVHDGVPAFPGSYSRPVTYYNANWNQLKKLTDVSTNCEQYIQWECYDTTFIR-----------DGYAWWMSRDNAKMTYWGGATPGSNKCACGMTSSCANPSNGCNCDSN---DQTWRSDGGLLTDKASLPVREMRFGDFDSSYE--AGYHTLGKLKCYG 189          

Query: 1556 ADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQ-YFTKDISLGKDFYIGGG-------RAAVSSFQGCLRNIYINN--VQVNYDPKNFDSSIRNGT---CSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQE---DPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCT--QNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAV------EITLDYSDQ-----------KISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDY-IVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFS--QVSKL--------GFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNI------TTDIPDWQRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGK---TNQPDVAGKEWW 4108
            + G S +DG WHSV L   +N   +  D    +T +      +  G  ++ GGG       R+   SFQGC++ I+I++  V +    +    +  N T   C++ID C+PN C+H   C+Q   TF+CNCS TGY+G  CH S    SC E  L+    QSS T  +D DGSG + PF+V CD +   + TT+  +N      V  H   G   L + YN  D + L  +  R+  CEQ ++Y C  ++LL  P G         F WWVGR  +  FYWGG  PGIQKC CGI+  C+     CNCD ++      + D+G+L  K  LPV++V +GDT+    G  + + VGPL+C GD  + N  +F    S ++      E   D+ F FKT+  + V L+SV   ++    ++IR G  + +T  +G   +++++ V++   LND+ WH V+ E+N KE+ L++D      H+E      + +      ++L +G+S S    ++GC   L +NGVI DL+    +  G+S GC   C+  +  C N G+C E Y+GY C+C LT Y G  C  +VG  F  G+ V      ++     D+           +++   E +   F T      L+ +SS   +  + + +  NG + I + +G      T D    ++ N Q H++   RS   +   +Q+D Y +   +    L   SD R +    +++G+ F   Q+  +        GF GC+ R+QFN++ PLK          V   G  +  +NCG   +           +      ++       T      R   I+G I++V+   +L +L+F  R+    +G Y T EAKGA+  D AD AI       T   D + +EW+
Sbjct:  434 SSGSSLNDGQWHSVHLNALENHAMLTVDGDEASTVRTAIPIQVQTGGIYFFGGGSFLAASSRSLQRSFQGCMQMIHIDDHLVDLRAVEQGLIGTFENVTLDMCAIIDRCVPNHCEHGGECSQTWDTFSCNCSGTGYTGATCHSSLYQQSCEEYELQ---GQSSGTYWIDPDGSGPIAPFRVHCDMTEETVWTTL-RNNLSPQTPVSSHDQYGKAVLQITYNATD-EQLWSVTSRAESCEQFVAYACRMSRLLNSPDG-------VPFTWWVGRANEKHFYWGGSGPGIQKCACGIENNCTDPGRFCNCDAEL---RAWKEDAGLLLYKDHLPVSQVVVGDTSKS--GSEAKLTVGPLKCRGDRSYWNAASFISPASSVHFQSFPGETSTDISFYFKTSSPHGVFLESVGSSSR--LHIQIRGGSVVLLTLEVGG--DLVQLSVHSPRPLNDDKWHRVQVEKNIKEAVLLLDGQ----HREVRAARTQAHAKLELYTDLFLGAS-SGQRSFLGCMRALKINGVIFDLERRAAETPGLSPGCQGHCSRYEMHCRNGGKCVEQYNGYSCDCSLTAYDGPFCTDDVGGYFETGTLVRYDFLPDMGAPVPDEMKGSPGWGLSGEVNLTREELVFSFSTHSAPSILVYISSRT-QDSLAVVLRQNGTLQIRYSLGGLMEPFTIDIDRRNMANGQPHSVNITRS--FREIRLQLDHYPLSTYT----LPETSDVRFNLVKSIFLGKVFETGQIDPVLIERYNTPGFVGCLSRVQFNSVAPLKAALRSGMTAPVSTHGI-LVPSNCGASPLTIPPMSSAHDPWHSETAGSVFPFKEEKTRADGVDRNSAIIGGIISVVIFSVLCILVFVVRHTFRHKGSYHTNEAKGAESADCADAAIIVNDPAFTETIDESKREWF 1308          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPY---GQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK--VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            GAG WS  D +  Q++QVDL  RK + AIA QGR  S+++   Y + +SD      W+    PY   G  + F GN N   V    L + I+ R++R  P  WNK   I VR EL+GC Y      FDG   + YR     + ++   D I  +F+T+  +G++L+ EG Q DYI++E+ R+RL + +NLG+    + +    +  +GS+LDD+ WH V I R  +++N TLD          +F HL+L+  +S GGL   A K      +NF+GC+E + ++G  I    RRK
Sbjct:   58 GAGGWSPLDTDRYQWLQVDLGSRKQVVAIATQGRYSSSDWTSKYRLLYSDAQ--RNWR----PYLQDGNIWTFEGNRNSEDVVRQELQHAILTRYIRFIPLEWNKDGRIGVRLELYGCSYWADVISFDGTGIISYRFRS--KKMKIVKDVITLKFRTTVRDGVLLHGEGQQGDYISLELSRARLLLSINLGSSEYGSIQGHTTVA-SGSLLDDDHWHSVVIERYRRNINFTLDHHTKHFRTNGEFDHLDLDYELSFGGLPASA-KLSSGGKENFLGCMEGITYNGENITSMVRRK 342          

Query: 1490 TVEVTL-DGVLPIAYSIPNP------DLTADGRSFSDGMWHSVELYLTKNKLTVVAD-QVTYNTFQYFTKDISLGKDFYIGG------GRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGT-----------CSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYN-TADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVE-----------------ITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTR--YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNF----------SQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTG-IRENNCGQXXXXXXXXXXXX-----XXXXXXXXFNITTDIPDW-QRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKE--MDTADNAIRYGKTNQP---DVAGKEWW 4108
            T+E++L DG + +  +  N       DL++ G   +DG WH+V L   +N   +  D + T          I+ G  +++GG         +  SFQGC++ I +++      P +  + +  GT           C++ID C+PN C+H   C Q   +F+C C  TGYSG  CH S    SC   + +  G +SS +  +D DGSG L PF+V+C+ +  N+ TT+VH+   K  +     +    R  L  N +A  + +  +   + YCEQ I+Y C  ++LL  P G         F WWVGR  +   YWGG  PGI+KC CGI   C+     CNCD D       + DSG+L  K  LPV++V +GDT     G  + + VGPLRC GD+ + N  +F+   S L+      E   D+ F FKT+    V L+++   N  F  + ++   T+  +F++G G +++       LND+ WH V  ERN KE+ L++D+    T +  P + +T     S+L VG++     G++GC   L +NG+  DL+       G+  GC   CT     C N G+C E Y+GY C+C  T Y G  C R++G  F  G+ V+                 +T   +  ++   +E +   F T      L+ +SS   + Y+ + +  NG + + + +G  +  + +  D   +L N Q H+L   R +  ++ +IQ+D Y  +  +    L   SD + +    +++G+ F           + +  GF GC+ R+QFN   PLK          +R +  G + E+NCG   +                   + PFN    IPD   R   I+G I+AV+   IL  L+F  R     +G Y T EAKG+ E   ++AD AI    T+ P   D + KEW+
Sbjct:  423 TLEISLLDGKIVVYINTSNAARNYQVDLSS-GSGLNDGQWHAVRLVAKENFAMLTVDGEETSAVRSTSPLSINTGGTYHLGGYFLQTLFPPSQHSFQGCMQAILVDD-----QPADLHA-VEKGTVGAFENVSLDMCAIIDRCMPNHCEHGGRCKQTWESFSCTCDGTGYSGATCHTSVYEPSCE--AYKHIG-KSSDSYWIDPDGSGPLGPFKVNCNMTEDNVWTTVVHNLAPKTAITGSSRER---RTVLQVNYSASMEQVTAITTSAEYCEQQIAYSCRMSRLLNTPDG-------TPFTWWVGRGSEKHLYWGGSGPGIKKCACGIDRNCTDPKYDCNCDAD---SRQWREDSGLLVYKEHLPVSQVAVGDTNRP--GSEAKLTVGPLRCHGDNNYWNAASFTTPSSYLHFATFQGETSADISFYFKTSAPYGVFLENLG--NTDFIRLELKSPETVSFSFDVGNGPVDLTVHSAAPLNDDQWHQVMAERNVKEAVLLLDQTY-RTSRPAPAQGHTRLELFSQLYVGAAGG-QRGFLGCIRALRMNGITLDLEERAKVTPGVEPGCQGHCTSFGMYCRNGGKCMERYNGYLCDCTATAYDGPFCTRDIGGFFEAGTLVKYNFLPEVVAGASKDSKALTKQLTPHEVDLTKEELAFSFSTSSAPAVLVYISSKT-QDYMAVVLKQNGSLQVRYSLGGLKEPFSIEVDQ-RNLANGQPHSLNMSRHN--RSISIQLDHYPPVSYT----LPDASDTQFNLVKTLFLGKVFETGFVDPVIIERYNTPGFIGCLSRVQFNRAAPLK--------SALRAATQGKLVESNCGASPLTIPPMSAATDPWHLDNTDALFPFNEERVIPDGVNRDSAIIGGIIAVVIFTILCTLVFLIRYMFRHKGTYHTNEAKGSGESAAESADTAII--GTDNPETIDESKKEWF 1318          

Query:  150 IKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            +  +   SSS FS   A  YA+L+            GAG WS  D +  Q++QVDL  RK ++AIA QGR  S+++   Y + +SD      WK +    G  + F GNSN  +V    L   IVAR +R+ P  W++   I +R E++GC Y    A FD  +  V       + ++   D I  RFKTS   G+IL+ EG Q DYIT+E+ +++L +++NLG+    +     ++   GS+LDDN WH V I R  +++N TLDR         +F +L+L+  ++ GG+  ++GK      +NF GC+E + ++G  I   ARRK
Sbjct:   51 LPHTAFTSSSVFSNGYAPGYAKLNRRG---------GAGGWSPLDSDHYQWLQVDLGSRKQVSAIATQGRYSSSDWTTRYRLLYSD--TGRNWKPYHQD-GNIWAFSGNSNSESVVRHELQQGIVARFLRLIPLAWSEEGRIGLRIEIYGCSYCECFA-FDKHALTVQV-----KKMKIIKDVIALRFKTSESEGVILHGEGQQGDYITLELRKAKLLLQINLGSNQYGSILGHTSVT-TGSLLDDNHWHSVVIERYRRNVNFTLDRHTQHFRTNGEFDYLDLDYELTFGGM-PYSGKPVGGGRKNFKGCMESINYNGDNITDLARRK 358          

Query: 1556 ADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQ-YFTKDISLGKDFYIGGG--RAAVSSFQGCLRNIYINN--VQVNYDPKNFDSSIRNGT---CSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQE---DPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCT--QNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAV------EITLDYSDQ-----------KISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDY-IVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFS--QVSKL--------GFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNI------TTDIPDWQRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGK---TNQPDVAGKEWW 4108
            + G S +DG WHSV L   +N   +  D    +T +      +  G  ++ GGG  R+   SFQGC++ I+I++  V +    +    +  N T   C++ID C+PN C+H   C+Q   TF+CNCS TGY+G  CH S    SC E  L+    QSS T  +D DGSG + PF+V CD +   + TT+  +N      V  H   G   L + YN  D    N   +  ++                      ++RY   F WWVGR  +  FYWGG  PGIQKC CGI+  C+     CNCD ++      + D+G+L  K  LPV++V +GDT+    G  + + VGPL+C GD  + N  +F    S ++      E   D+ F FKT+  + V L+SV   ++    ++IR G  + +T  +G   +++++ V++   LND+ WH V+ E+N KE+ L++D      H+E      + +      ++L +G+S S    ++GC   L +NGVI DL+    +  G+S GC   C+  +  C N G+C E Y+GY C+C LT Y G  C  +VG  F  G+ V      ++     D+           +++   E +   F T      L+ +SS   +  + + +  NG + I + +G      T D    ++ N Q H++   RS   +   +Q+D Y +   +    L   SD R +    +++G+ F   Q+  +        GF GC+ R+QFN++ PLK          V   G  +  +NCG   +           +      ++       T      R   I+G I++V+   +L +L+F  R+    +G Y T EAKGA+  D AD AI       T   D + +EW+
Sbjct:  461 SSGSSLNDGQWHSVHLNALENHAMLTVDGDEASTVRTAIPIQVQTGGIYFFGGGDSRSLQRSFQGCMQMIHIDDHLVDLRAVEQGLIGTFENVTLDMCAIIDRCVPNHCEHGGECSQTWDTFSCNCSGTGYTGATCHSSLYQQSCEEYELQ---GQSSGTYWIDPDGSGPIAPFRVHCDMTEETVWTTL-RNNLSPQTPVSSHDQYGKAVLQITYNATDEQVSNSTSQTCSFV---------------------SSRYGVPFTWWVGRANEKHFYWGGSGPGIQKCACGIENNCTDPGRFCNCDAEL---RAWKEDAGLLLYKDHLPVSQVVVGDTSKS--GSEAKLTVGPLKCRGDRSYWNAASFISPASSVHFQSFPGETSTDISFYFKTSSPHGVFLESVGSSSR--LHIQIRGGSVVLLTLEVGG--DLVQLSVHSPRPLNDDKWHRVQVEKNIKEAVLLLDGQ----HREVRAARTQAHAKLELYTDLFLGAS-SGQRSFLGCMRALKINGVIFDLERRAAETPGLSPGCQGHCSRYEMHCRNGGKCVEQYNGYSCDCSLTAYDGPFCTDDVGGYFETGTLVRYDFLPDMGAPVPDEMKGSPGWGLSGEVNLTREELVFSFSTHSAPSILVYISSRT-QDSLAVVLRQNGTLQIRYSLGGLMEPFTIDIDRRNMANGQPHSVNITRS--FREIRLQLDHYPLSTYT----LPETSDVRFNLVKSIFLGKVFETGQIDPVLIERYNTPGFVGCLSRVQFNSVAPLKAALRSGMTAPVSTHGI-LVPSNCGASPLTIPPMSSAHDPWHSETAGSVFPFKEEKTRADGVDRNSAIIGGIISVVIFSVLCILVFVVRHTFRHKGSYHTNEAKGAESADCADAAIIVNDPAFTETIDESKREWF 1317          

Query:  258 GAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPY---GQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK--VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            GAG WS  D +  Q++QVDL  RK + AIA QGR  S+++   Y + +SD      W+    PY   G  + F GN N   V    L + I+ R++R  P  WNK   I VR EL+GC Y      FDG   + YR     + ++   D I  +F+T+  +G++L+ EG Q DYI++E+ R+RL + +NLG+    + +    +  +GS+LDD+ WH V I R  +++N TLD          +F HL+L+  +S GGL   A K      +NF+GC+E + ++G  I    RRK
Sbjct:   85 GAGGWSPLDTDRYQWLQVDLGSRKQVVAIATQGRYSSSDWTSKYRLLYSDAQ--RNWR----PYLQDGNIWTFEGNRNSEDVVRQELQHAILTRYIRFIPLEWNKDGRIGVRLELYGCSYWADVISFDGTGIISYRFRS--KKMKIVKDVITLKFRTTVRDGVLLHGEGQQGDYISLELSRARLLLSINLGSSEYGSIQGHTTVA-SGSLLDDDHWHSVVIERYRRNINFTLDHHTKHFRTNGEFDHLDLDYELSFGGLPASA-KLSSGGKENFLGCMEGITYNGENITSMVRRK 369          

Query: 1490 TVEVTL-DGVLPIAYSIPNP------DLTADGRSFSDGMWHSVELYLTKNKLTVVAD-QVTYNTFQYFTKDISLGKDFYIGGG------RAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGT-----------CSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYN-TADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYG-IEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQ--NPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVE-----------------ITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTR--YEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNF----------SQVSKLGFTGCIYRLQFNNIFPLK 3733
            T+E++L DG + +  +  N       DL++ G   +DG WH+V L   +N   +  D + T          I+ G  +++GG         +  SFQGC++ I +++      P +  + +  GT           C++ID C+PN C+H   C Q   +F+C C  TGYSG  CH S    SC   + +  G +SS +  +D DGSG L PF+V+C+ +  N+ TT+VH+   K  +     +    R  L  N +A  + +  +   + YCEQ I+Y C  ++LL  P G         F WWVGR  +   YWGG  PGI+KC CGI   C+     CNCD D       + DSG+L  K  LPV++V +GDT     G  + + VGPLRC GD+ + N  +F+   S L+      E   D+ F FKT+    V L+++   N  F  + ++   T+  +F++G G +++       LND+ WH V  ERN KE+ L++D+    T +  P + +T     S+L VG++     G++GC   L +NG+  DL+       G+  GC   CT     C N G+C E Y+GY C+C  T Y G  C R++G  F  G+ V+                 +T   +  ++   +E +   F T      L+ +SS   + Y+ + +  NG + + + +G  +  + +  D   +L N Q H+L   R +  ++ +IQ+D Y  +  +    L   SD + +    +++G+ F           + +  GF GC+ R+QFN   PLK
Sbjct:  420 TLEISLLDGKIVVYINTSNAARNYQVDLSS-GSGLNDGQWHAVRLVAKENFAMLTVDGEETSAVRSTSPLSINTGGTYHLGGYFLQTLFPPSQHSFQGCMQAILVDD-----QPADLHA-VEKGTVGAFENVSLDMCAIIDRCMPNHCEHGGRCKQTWESFSCTCDGTGYSGATCHTSVYEPSCE--AYKHIG-KSSDSYWIDPDGSGPLGPFKVNCNMTEDNVWTTVVHNLAPKTAITGSSRER---RTVLQVNYSASMEQVTAITTSAEYCEQQIAYSCRMSRLLNTPDG-------TPFTWWVGRGSEKHLYWGGSGPGIKKCACGIDRNCTDPKYDCNCDAD---SRQWREDSGLLVYKEHLPVSQVAVGDTNRP--GSEAKLTVGPLRCHGDNNYWNAASFTTPSSYLHFATFQGETSADISFYFKTSAPYGVFLENLG--NTDFIRLELKSPETVSFSFDVGNGPVDLTVHSAAPLNDDQWHQVMAERNVKEAVLLLDQTY-RTSRPAPAQGHTRLELFSQLYVGAAGG-QRGFLGCIRALRMNGITLDLEERAKVTPGVEPGCQGHCTSFGMYCRNGGKCMERYNGYLCDCTATAYDGPFCTRDIGGFFEAGTLVKYNFLPEVVAGASKDSKALTKQLTPHEVDLTKEELAFSFSTSSAPAVLVYISSKT-QDYMAVVLKQNGSLQVRYSLGGLKEPFSIEVDQ-RNLANGQPHSLNMSRHN--RSISIQLDHYPPVSYT----LPDASDTQFNLVKTLFLGKVFETGFVDPVIIERYNTPGFIGCLSRVQFNRAAPLK 1188          

Query:  150 IKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKV--ISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            +  +   SSS FS   A  YA+L+            GAG WS  D +  Q++QVDL  RK ++AIA QGR  S+++   Y + +SD      WK +    G  + F GNSN  +V    L   IVAR +R+ P  W++   I +R E++GC Y      FDG+  + YR     + ++   D I  RFKTS   G+IL+ EG Q DYIT+E+ +++L +++NLG+    +     ++   GS+LDDN WH V I R  +++N TLDR         +F +L+L+  ++ GG+  ++GK      +NF GC+E + ++G  I   ARRK
Sbjct:   44 LPHTAFTSSSVFSNGYAPGYAKLNRRG---------GAGGWSPLDSDHYQWLQVDLGSRKQVSAIATQGRYSSSDWTTRYRLLYSD--TGRNWKPYHQD-GNIWAFSGNSNSESVVRHELQQGIVARFLRLIPLAWSEEGRIGLRIEIYGCSYWADVINFDGQGVISYRFKV--KKMKIIKDVIALRFKTSESEGVILHGEGQQGDYITLELRKAKLLLQINLGSNQYGSILGHTSVT-TGSLLDDNHWHSVVIERYRRNVNFTLDRHTQHFRTNGEFDYLDLDYELTFGGM-PYSGKPVGGGRKNFKGCMESINYNGDNITDLARRK 355          

Query: 1556 ADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQY---FTKDISLGKDFYIGGG----------RAAVSSFQGCLRNIYINNVQVNYD-----PKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNN---LNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQN--PCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVE------------------------ITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFT--RYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGR---------NFSQVSKLGFTGCIYRLQFNNIFPLKMLFN-DEPLPNVRVSGTGIRENNCG 3805
            A G   +DG WHSV+L    N LT+  D+   +  +    FT  I  G  ++ GG              ++ F GC+++I+I+N Q++ D          + +  GTC + D C PNPC+HE  C Q    F C C  TGY G+VCH S    SC   + R +G   S   T+D D SG L P++V C    +   T I+H   +   +    +D   +   + Y  A  D +  L   S YCEQ I Y C+ ++LL  P G       + F +W+GR  +  +YWGG    +QKC C +  TC      CNCD D        +D G L  +  LPV ++ +GDT     G  +   VGPLRC GD    NTI F+K   + + P +      D+ F FKT   N V L++     + F  V +     L + F +G G  I+ V +++   LNDN WH V+ E N K +R+ +D   P   +  P + + T  F   L+VG++      ++GC   L +NG   DL+  + +  GI   C  +C     PC N G+C E Y+ Y C+C  T + G+ C +++GA F  GS +                          +L Y+D       + IE  F T      LL +SS   + YI + + N+G + + + +G    +Y++T     +L +   H +   R +  +T   QVD      +  +  ++   DAR D P  +Y+GR            + +  GF GCI  +++N   PLK LF  +E  P V   G  + E+NCG
Sbjct:  436 AAGYRLNDGYWHSVDLAARDNLLTLTIDEEEASPLKITNPFT--IRTGDRYFFGGCPKTNNTIRKCETKLNRFHGCMQHIFIDNEQLDIDIILQRQWGRYAELLLGTCGITDRCTPNPCEHEGRCIQSWDDFICLCENTGYKGEVCHMSVYKESCE--AYRLSGKYWSGNYTIDPDLSGPLRPYEVYCKMKSYKAWTVIMHDRVDGTKVSGSSID-QPYIGDINYWNASWDEVTALANTSMYCEQWIDYSCYKSRLLNTPNG-------RPFSYWIGRNNESHYYWGGTFREVQKCGCAVNQTCVDPKFQCNCDADY---RQWFSDKGYLDFRDHLPVRKLVIGDTNRT--GSQAQFTVGPLRCHGDRNIWNTIAFTKPTYITF-PTLRPGTTIDISFHFKTYRGNCVFLENSDDHLKNFIRVELNTTQNLALVFMVGDG--ILNVTLHSPVPLNDNEWHFVQAELNVKVARIKVDYQ-PWAVKRFPGQTFVTMQFTHPLLVGAANRTLRPFLGCLRGLRINGAPFDLEGKVNEAQGIRRNCTGQCLNATIPCRNSGQCIEGYASYTCDCNNTAFDGFYCHKDIGAFFEIGSWLRYNVRKKPVSDEAAWANWIDPHYDNFSLGYNDTA-----DDIEFSFSTVHTPAVLLYISSF-VQDYIAVILKNDGSVDLRYKLGLITHKYQLTHR---NLADGFPHYVNITRHN--RTIKTQVD----YMEPIVEKITLVEDARFDSPRSMYLGRVMEVGDIDYEIQRHNAPGFIGCISGVRYNVYAPLKALFRPNETDPPVTTQGY-VSESNCG 1207          

Query:   33 MLKIIIVYLFFNYFYNDIASQDCSILPERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNK----VISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDN--ILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRK 1127
            +L I +++L F       AS +C      PL      +G+  S   +SS ++   +  +A+L+            G+  WS    + Q ++QV+L  +  + AIA QG   S ++V  Y + +  GD P+ W  +    G   L  GN N   V      Y   A+H+R+ P  WN      I VR ELFGC Y     Q++G   V+Y    P +  +T  D I   FKT   +GL+L++EG Q D  T+E+ + RL + ++LG+ V      +D    L AGS+LD+  WH V I+R  + +N+T+D   +      DF HL+L+  + VGG+        +    NF GC+E +  + + +I  A+R+
Sbjct:    5 VLTICLLFLGFQ----QCASDECV----DPL-----VSGLYASAFWASSRYNFLYSANFAKLY------------GSSGWSPSPRDRQPWLQVNLGMKYRLRAIATQGTFNSYDWVTKYMILY--GDRPDSWTPYIMQGGNSTLP-GNWNYYQVKRNVFHYAFTAKHIRLLPLAWNTENGGKIGVRLELFGCPYDSSVLQYNGDDSVIYMY--PEKRSRTLRDHIALNFKTLEQDGLLLHSEGIQGDLFTLELKKGRLYLHISLGSSV---LHKIDGRITLTAGSLLDNLHWHYVTIKRHGRQVNLTVDSQTVTAICKGDFTHLDLDSQMYVGGVIE-PNLPHLPTTPNFRGCLENVFINDINVIDMAKRE 341          

Query: 1475 ITGYLTVEVTLDGVLPIAYSIPNPDLTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQXXXXXXXXXXXXXXXXXXXXFNITTDIPDWQRTGIIVGVIMAXXXXXXXXXXXXXXRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTNQPDVAGKEWW 4108
            ITGYLTVEVTLDGVLPIAYSIPNPDLTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVSTQTTSQTDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKC+QNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQEEIMPRMEPIEIKIYPPIPPFNITTDIPDWQRTGIIVGVIMAVIFLVILILLIFFFRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTNQPDVAGKEWW
Sbjct:  482 ITGYLTVEVTLDGVLPIAYSIPNPDLTADGRSFSDGMWHSVELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINNVQVNYDPKNFDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNPTSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFRLPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFYWGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVSTQTTSQTDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWHVVRFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSSQSFTDGYVGCFSNLIVNGVIQDLKSAITDPYGISIGCNPKCSQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVNNNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLGFTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENNCGQEEIMPRMEPIEIKIYPPIPPFNITTDIPDWQRTGIIVGVIMAVIFLVILILLIFFFRNFTVERGDYDTREAKGAKEMDTADNAIRYGKTNQPDVAGKEWW 1359          

Query:   33 MLKIIIVYLFFNYFYNDIASQDCSILPERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWYPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRKVNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIEGLSSISFKVTFRTFAVNGMLFYHVVDLMFTQFISLSINK 1475
            MLKIIIVYLFFNYFYNDIASQDCSILPERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLW PTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARR VNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIEGLSSISFKVTFRTFAVNGMLFYHVVDLMFTQFISLSINK
Sbjct:    1 MLKIIIVYLFFNYFYNDIASQDCSILPERPLGMSDRYNGIKDSQIKSSSDFSLDTAGKYARLHYSDAFLWDPTIPGAGAWSARDMNTQQFVQVDLLERKVITAIAIQGRQGSNEFVKDYYVEFSDGDVPELWKLFRDPYGQPFLFFGNSNDNTVALTNLTYPIVARHVRIRPQRWNKVISVRFELFGCIYKPWTAQFDGKSRVVYRLDQPGRAIQTRADKIKFRFKTSNINGLILYAEGDQFDYITIEMFRSRLRVRMNLGAKVNVAPESMDNILDAGSMLDDNQWHDVEIRRAEKDLNVTLDRVKMWRNLTSDFIHLNLNRNISVGGLGNFAGKRGISVMQNFIGCIEEMVFDGLYIIRDARRMVNMAANGNRNWQDVLYYPPMNSRIWWGDELTESQLGIANFDIVGNVGSDCPPPSSFQNVITFPSIDSNGIYGKVTIEGLSSISFKVTFRTFAVNGMLFYHVVDLMFTQFISLSINK 481          

Query: 1595 VELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINN---------VQVNYDPKN------FDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNP------------------TSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFR--LPLVYNTADRDALNELVRRSTYC----------EQSISYKCFNAKLLKL-----PGGGGTNRYNQAFGWWVGRRGQPLFY--WGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN---NLNDNFWHVV---RFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVG-----SSQSFTD------GYVGCFSNLIVNG-----VIQDLKSAITDPYGISIGCNPK-----CTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVE----ITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVN-NNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLG--FTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENN 3799
            V+L    N   ++ +Q + N+ +YF  ++ +               FQGC+  + +N+         + V     N      + S I    CS +     +PC ++  C       +CNC  T Y G++C++                      T    I +RF+ +  +  +        +L P     DFS FN ++ ++   N   +L+   + P S R    L  N +D    + ++ R+             +Q +++   N KL  +      G G  N       W     G  L Y  +    P   K       +   +    N  G ++    +  D  ++ D   L     RL D   K++ +     V P    G      ++TF    + L +  +     F + F  KT   + V+L  +S  +  F  + +  G  ++++FN+G  ++I+    +   +L DN WH++   R + +R    L ID+                FNFD    +G       Q +T+      G+ GC +   +NG     ++Q     I D Y   I  N +     C  N C N G+C + +    C+C  T + G  C + V A+      V     I L + D+  +T  + I  G +T+   GT++ V S    K   I +   NG I +E+D+G    ++ TD  + + +  +  ++  R  +G +  +Q+D+ R    S +     N     ++ + +Y+G   S + K G  F G I  L FN I    +L + +  P + VS  G  E N
Sbjct:  360 VDLSALFNSEIILGNQFSLNSVKYFPSEVWMA---------TLRKGFQGCIEKVILNDEVFDLKRSLLSVKLKQSNLTIKGCYTSIISPSECSKLK-SKSSPCANQGYCENYWPEISCNCDFTNYKGRICNKGTRAIEFDGSEFIRLDLGTEFYTEVESILIRFSTIYPTGYLL-------SLNP----SDFSEFNSSSILLSIENGLLILI---IQPQSERQIFKLTNNVSDGQWHSLIISRNNRALSLNLDGKILQQEVNFHS-NEKLQIVWKSINIGFGAINSNETILSWQQLHIGASLKYNDYHYNRPFSPKVWMIKTNSDQKDGLKPNFVGKINKLRINSVD--IIDDYILLN----RLSDHQWKMQAQ-----VNP-NAIGSKHVVYSVTFHTPQAYLLVHKLHLYGSFSLAFYLKTNQKDGVLLM-ISGTSNDFLLMELIHG-GIKLSFNMGSTVQILTDNCHGSCSLADNKWHLLEISRLDLSRNVLSLSIDKVMIEEVTIHNSHKAKNFNFDRPAYLGGMPRYEYQKWTEYIFSNYGFQGCIAGFSINGKKPINLLQYSIVEIPDVYKSQIAHNCQSNLTICKDNHCKNGGQCLQQFEQASCDCSYTTFEGRFCTK-VSATINFRRQVASNNYIQLQFQDRTRNTSRDDIAFGLQTRKLDGTIIFVESKRKDKGDFIHLFLENGKIILEYDMGAGIMKL-TDLSIKVSDGFYRRVRVRR--LGSSAWLQIDNSR----SELERTDLNLGRSFNEQSIIYIGA--SPIKKEGKQFVGLISGLIFNGIKIPYVLEHKKEFPYIFVSIFGDVEIN 1131          

Query: 1595 VELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINN---------VQVNYDPKN------FDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNP------------------TSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFR--LPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFY--WGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN---NLNDNFWHVV---RFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVG-----SSQSFTD------GYVGCFSNLIVNG-----VIQDLKSAITDPYGISIGCNPK-----CTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVE----ITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVN-NNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLG--FTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENN 3799
            V+L    N   ++ +Q + N+ +YF  ++ +               FQGC+  + +N+         + V     N      + S I    CS +     +PC ++  C       +CNC  T Y G++C++                      T    I +RF+ +  +  +        +L P     DFS FN ++ ++   N   +L+   + P S R    L  N +D    + ++ R+    +++S    + K+L+       N       W     G  L Y  +    P   K       +   +    N  G ++    +  D  ++ D   L     RL D   K++ +     V P    G      ++TF    + L +  +     F + F  KT   + V+L  +S  +  F  + +  G  ++++FN+G  ++I+    +   +L DN WH++   R + +R    L ID+                FNFD    +G       Q +T+      G+ GC +   +NG     ++Q     I D Y   I  N +     C  N C N G+C + +    C+C  T + G  C + V A+      V     I L + D+  +T  + I  G +T+   GT++ V S    K   I +   NG I +E+D+G    ++ TD  + + +  +  ++  R  +G +  +Q+D+ R    S +     N     ++ + +Y+G   S + K G  F G I  L FN I    +L + +  P + VS  G  E N
Sbjct:  360 VDLSALFNSEIILGNQFSLNSVKYFPSEVWMA---------TLRKGFQGCIEKVILNDEVFDLKRSLLSVKLKQSNLTIKGCYTSIISPSECSKLK-SKSSPCANQGYCENYWPEISCNCDFTNYKGRICNKGTRAIEFDGSEFIRLDLGTEFYTEVESILIRFSTIYPTGYLL-------SLNP----SDFSEFNSSSILLSIENGLLILI---IQPQSERQIFKLTNNVSDGQWHSLIISRNN---RALSLN-LDGKILQ----QAINSNETILSWQQLHIGASLKYNDYHYNRPFSPKVWMIKTNSDQKDGLKPNFVGKINKLRINSVD--IIDDYILLN----RLSDHQWKMQAQ-----VNP-NAIGSKHVVYSVTFHTPQAYLLVHKLHLYGSFSLAFYLKTNQKDGVLLM-ISGTSNDFLLMELIHG-GIKLSFNMGSTVQILTDNCHGSCSLADNKWHLLEISRLDLSRNVLSLSIDKVMIEEVTIHNSHKAKNFNFDRPAYLGGMPRYEYQKWTEYIFSNYGFQGCIAGFSINGKKPINLLQYSIVEIPDVYKSQIAHNCQSNLTICKDNHCKNGGQCLQQFEQASCDCSYTTFEGRFCTK-VSATINFRRQVASNNYIQLQFQDRTRNTSRDDIAFGLQTRKLDGTIIFVESKRKDKGDFIHLFLENGKIILEYDMGAGIMKL-TDLSIKVSDGFYRRVRVRR--LGSSAWLQIDNSR----SELERTDLNLGRSFNEQSIIYIGA--SPIKKEGKQFVGLISGLIFNGIKIPYVLEHKKEFPYIFVSIFGDVEIN 1109          

Query: 1595 VELYLTKNKLTVVADQVTYNTFQYFTKDISLGKDFYIGGGRAAVSSFQGCLRNIYINN---------VQVNYDPKN------FDSSIRNGTCSMIDLCIPNPCKHEAPCTQDGRTFTCNCSLTGYSGQVCHQSQNP------------------TSCSEISLRFAGMQSSKTVTVDLDGSGALTPFQVDCDFSVFNITTTIVHHNNEKDVLVEGHLDPGSFR--LPLVYNTADRDALNELVRRSTYCEQSISYKCFNAKLLKLPGGGGTNRYNQAFGWWVGRRGQPLFY--WGGGIPGIQKCQCGIQGTCSGNSGTCNCDGDVXXXXXXXXDSGMLTDKSDLPVTEVRLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN---NLNDNFWHVV---RFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVG-----SSQSFTD------GYVGCFSNLIVNG-----VIQDLKSAITDPYGISIGCNPK-----CTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVE----ITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVN-NNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLG--FTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENN 3799
            V+L    N   ++ +Q + N+ +YF  ++ +               FQGC+  + +N+         + V     N      + S I    CS +     +PC ++  C       +CNC  T Y G++C++                      T    I +RF+ +  +  +        +L P     DFS FN ++ ++   N   +L+   + P S R    L  N +D    + ++ R+    +++S    + K+L+       N       W     G  L Y  +    P   K       +   +    N  G ++    +  D  ++ D   L     RL D   K++ +     V P    G      ++TF    + L +  +     F + F  KT   + V+L  +S  +  F  + +  G  ++++FN+G  ++I+    +   +L DN WH++   R + +R    L ID+                FNFD    +G       Q +T+      G+ GC +   +NG     ++Q     I D Y   I  N +     C  N C N G+C + +    C+C  T + G  C + V A+      V     I L + D+  +T  + I  G +T+   GT++ V S    K   I +   NG I +E+D+G    ++ TD  + + +  +  ++  R  +G +  +Q+D+ R    S +     N     ++ + +Y+G   S + K G  F G I  L FN I    +L + +  P + VS  G  E N
Sbjct:  550 VDLSALFNSEIILGNQFSLNSVKYFPSEVWMA---------TLRKGFQGCIEKVILNDEVFDLKRSLLSVKLKQSNLTIKGCYTSIISPSECSKLK-SKSSPCANQGYCENYWPEISCNCDFTNYKGRICNKGTRAIEFDGSEFIRLDLGTEFYTEVESILIRFSTIYPTGYLL-------SLNP----SDFSEFNSSSILLSIENGLLILI---IQPQSERQIFKLTNNVSDGQWHSLIISRNN---RALSLN-LDGKILQ----QAINSNETILSWQQLHIGASLKYNDYHYNRPFSPKVWMIKTNSDQKDGLKPNFVGKINKLRINSVD--IIDDYILLN----RLSDHQWKMQAQ-----VNP-NAIGSKHVVYSVTFHTPQAYLLVHKLHLYGSFSLAFYLKTNQKDGVLLM-ISGTSNDFLLMELIHG-GIKLSFNMGSTVQILTDNCHGSCSLADNKWHLLEISRLDLSRNVLSLSIDKVMIEEVTIHNSHKAKNFNFDRPAYLGGMPRYEYQKWTEYIFSNYGFQGCIAGFSINGKKPINLLQYSIVEIPDVYKSQIAHNCQSNLTICKDNHCKNGGQCLQQFEQASCDCSYTTFEGRFCTK-VSATINFRRQVASNNYIQLQFQDRTRNTSRDDIAFGLQTRKLDGTIIFVESKRKDKGDFIHLFLENGKIILEYDMGAGIMKL-TDLSIKVSDGFYRRVRVRR--LGSSAWLQIDNSR----SELERTDLNLGRSFNEQSIIYIGA--SPIKKEGKQFVGLISGLIFNGIKIPYVLEHKKEFPYIFVSIFGDVEIN 1299          

Query: 2525 RLGDTTTKVEGKSSIINVGPLRCTGDSLFDNTITFSKHDSVLYLPPMFAENEFDMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVN---NLNDNFWHVV---RFERNRKESRLIIDENAPVTHQEDPDRPYTTFNFDSELIVGSS-----QSFTD------GY---------------------VGCFSNLIVNG-----VIQDLKSAITDPYGISIGCNPK-----CTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVE----ITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKYIIIKVN-NNGGITIEFDVGFTRYEVTTDYIVDLCNDQHHTLKAWRSDMGQTWNIQVDDYRIIKKSFISILSANSDARLDKPTYVYVGRNFSQVSKLG--FTGCIYRLQFNNIFPLKMLFNDEPLPNVRVSGTGIRENN 3799
            RL D   K++ +     V P    G      ++TF    + L +  +     F + F  KT   + V+L  +S  +  F  + +  G  ++++FN+G  ++I+    +   +L DN WH++   R + +R    L ID+                FNFD    +G       Q +T+      G+                     +GC +   +NG     ++Q     I D Y   I  N +     C  N C N G+C + +    C+C  T + G  C + V A+      V     I L + D+  +T  + I  G +T+   GT++ V S    K   I +   NG I +E+D+G    ++ TD  + + +  +  ++  R  +G +  +Q+D+ R    S +     N     ++ + +Y+G   S + K G  F G I  L FN I    +L + +  P + VS  G  E N
Sbjct:  669 RLSDHQWKMQAQ-----VNP-NAIGSKHVVYSVTFHTPQAYLLVHKLHLYGSFSLAFYLKTNQKDGVLLM-ISGTSNDFLLMELIHG-GIKLSFNMGSTVQILTDNCHGSCSLADNKWHLLEISRLDLSRNVLSLSIDKVMIEEVTIHNSHKAKNFNFDRPAYLGGMPRYEYQKWTEYIFSNYGFQKTVHPTSIRSSDILGKSFDVMGCIAGFSINGKKPINLLQYSIVEIPDVYKSQIAHNCQSNLTICKDNHCKNGGQCLQQFEQASCDCSYTTFEGRFCTK-VSATINFRRQVASNNYIQLQFQDRTRNTSRDDIAFGLQTRKLDGTIIFVESKRKDKGDFIHLFLENGKIILEYDMGAGIMKL-TDLSIKVSDGFYRRVRVRR--LGSSAWLQIDNSR----SELERTDLNLGRSFNEQSIIYIGA--SPIKKEGKQFVGLISGLIFNGIKIPYVLEHKKEFPYIFVSIFGDVEIN 1130          

Query: 2615 NTITFSKHDSVLYLPPMFAENEF-DMIFLFKTTVSNAVILQSVSKQNQQFFEVRIREGFTLRVTFNLGYGIEIIEVVVNNLNDNFWH----VVRFERNRKESRLIIDENAPVTHQEDPD---RPYTTFN-----------FDSELIVGSSQSFTD---------------GYVGCFSNLIVNGVIQDLKSAITD----PYGISI-GC-----NP------KCTQNPCLNRGECYELYSGYYCECGLTPYRGYVCGREVGASFIDGSAVEITLDYSDQKISTLEEYIEIGFKTKDKQGTLLQVSSNDFKKY----IIIKVNNNGGITI 3433
            N I+F    S + L       EF D+   F+   ++ +I    SK N  F  V  R+         L  GI +   VV       W+    ++  ER+      +   N     + + D     +  FN           F+SE+I+G+  S                  G+ GC   +I+N  + DLK ++         ++I GC     +P      K   +PC N+G C   +    C C  T Y+G +C +   A   DGS   I LD   +  + +E  I I F T    G LL ++ +DF ++    I++ + N   I I
Sbjct:  239 NPISFLSQTSFVVLKTKTQPYEFYDLKLSFQPQTTSFIIYFHRSKNNDHFISVEARDR-------QLIIGISVHHKVV------MWYPEECLIDIERSYSIHLYVDYMNGKAKLKFNNDISVEKFIIFNTSDFPVDLSALFNSEIILGNQFSLNSVKYFPSEVWMATLRKGFQGCIEKVILNDEVFDLKRSLLSVKLKQSNLTIKGCYTSIISPSECSKLKSKSSPCANQGYCENYWPEISCNCDFTNYKGRICNKGTRAIEFDGSEF-IRLDLGTEFYTEVES-ILIRFSTIYPTGYLLSLNPSDFSEFNSSSILLSIENGLLILI 550