GTP-binding nuclear protein

Overview


Name	GTP-binding nuclear protein
Smed ID	SMED30030013
Length (bp)	837

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of GTP-binding nuclear protein (SMED30030013) t-SNE clustered cells

Violin plots show distribution of expression levels for GTP-binding nuclear protein (SMED30030013) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of GTP-binding nuclear protein (SMED30030013) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for GTP-binding nuclear protein (SMED30030013) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30030013

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 26

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
X1 cell	SMED30030013	h1SMcG0019920	SmedASXL_004044	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
Smed sexual biotype	SMED30030013	h1SMcG0019920	Contig38852	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30030013	h1SMcG0019920	Contig38852	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
pharynx	SMED30030013	h1SMcG0019919	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30030013	h1SMcG0019919	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30030013	h1SMcG0019919	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30030013	h1SMcG0019919	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30030013	h1SMcG0019919	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30030013	h1SMcG0019919	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30030013	h1SMcG0019919	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30030013	h1SMcG0019919	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30030013	h1SMcG0019919	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
pharynx	SMED30030013	h1SMcG0019920	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30030013	h1SMcG0019920	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30030013	h1SMcG0019920	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30030013	h1SMcG0019920	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30030013	h1SMcG0019920	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30030013	h1SMcG0019920	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30030013	h1SMcG0019920	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30030013	h1SMcG0019920	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30030013	h1SMcG0019920	dd_Smed_v4_330_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30030013	h1SMcG0019920	SMED30030013	smed_20140614	PMID:22696458 Labbé et al., 2012
gamma neoblast	SMED30030013	h1SMcG0019920	dd_Smed_v6_330_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
neoblast	SMED30030013	h1SMcG0019920	dd_Smed_v6_330_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
gamma neoblast	SMED30030013	h1SMcG0019919	dd_Smed_v6_330_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018
neoblast	SMED30030013	h1SMcG0019919	dd_Smed_v6_330_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of GTP-binding nuclear protein vs. Ensembl Human
Match: RAN (RAN, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9846])

HSP 1 Score: 354.755 bits (909), Expect = 2.527e-124
Identity = 166/188 (88.30%), Postives = 175/188 (93.09%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             G+   QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    4 QGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 191

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Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             G+   QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    4 QGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 191

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BLAST of GTP-binding nuclear protein vs. Ensembl Human
Match: RAN (RAN, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9846])

HSP 1 Score: 348.206 bits (892), Expect = 1.629e-121
Identity = 169/199 (84.92%), Postives = 178/199 (89.45%), Query Frame = 1

Query:   55 NC----FKKMSGDAVAQF-KLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
            NC    F    G A  +F KLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:   11 NCASAIFPASVGRARRRFWKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 209

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BLAST of GTP-binding nuclear protein vs. Ensembl Human
Match: RAN (RAN, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9846])

HSP 1 Score: 346.28 bits (887), Expect = 2.766e-121
Identity = 163/185 (88.11%), Postives = 173/185 (93.51%), Query Frame = 1

Query:   82 AVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
            A  + +LVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    3 AQGEPQLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 187

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BLAST of GTP-binding nuclear protein vs. Ensembl Human
Match: RAN (RAN, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9846])

HSP 1 Score: 345.125 bits (884), Expect = 2.620e-120
Identity = 166/205 (80.98%), Postives = 175/205 (85.37%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQ-----------------GQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             G+   QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ                  QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    4 QGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQEMGIHHVAHAGLELMSSAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 208

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BLAST of GTP-binding nuclear protein vs. Ensembl Celegans
Match: ran-1 (GTP-binding nuclear protein ran-1 [Source:UniProtKB/Swiss-Prot;Acc:O17915])

HSP 1 Score: 358.992 bits (920), Expect = 1.787e-126
Identity = 167/191 (87.43%), Postives = 178/191 (93.19%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWV 645
             GD +  FKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG+IRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVT+R+TYKNVPNWHRDL RVCENIPIVL GNKVD+KDRKVKAKTITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP  +
Sbjct:    3 GGDGIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGQIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTARVTYKNVPNWHRDLARVCENIPIVLCGNKVDVKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLLGDPNLEFVAMPALAPPEVQMDPAMI 193

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BLAST of GTP-binding nuclear protein vs. Ensembl Celegans
Match: rab-7 (RAB family [Source:UniProtKB/TrEMBL;Acc:Q23146])

HSP 1 Score: 115.161 bits (287), Expect = 6.022e-31
Identity = 61/180 (33.89%), Postives = 98/180 (54.44%), Query Frame = 1

Query:   88 AQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKD-RKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMP 603
            A  K++++GD G GKT+ + ++V   F  +Y AT+G +    + N     +   +WDTAGQE+F  L   +Y    C ++ FDVT+  ++K++ +W  + +     R  ++ P VL+GNKVD++  R V +K        K N+ YY+VSAK   N E  FL IAR  +   + E  + P
Sbjct:    8 ALLKVIILGDSGVGKTSLMNQYVNRRFSNQYKATIGADFLTRDVNIDDRTVTLQIWDTAGQERFQSLGVAFYRGADCCVLAFDVTNAASFKSLDSWRDEFLIQASPRDPDHFPFVLLGNKVDLESQRAVSSKRAQSWCQTKGNIPYYEVSAKEALNVEAAFLAIARDALARESQETNDFP 187

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Query:   88 AQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKD-RKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMP 603
            A  K++++GD G GKT+ + ++V   F  +Y AT+G +    + N     +   +WDTAGQE+F  L   +Y    C ++ FDVT+  ++K++ +W  + +     R  ++ P VL+GNKVD++  R V +K        K N+ YY+VSAK   N E  FL IAR  +   + E  + P
Sbjct:    8 ALLKVIILGDSGVGKTSLMNQYVNRRFSNQYKATIGADFLTRDVNIDDRTVTLQIWDTAGQERFQSLGVAFYRGADCCVLAFDVTNAASFKSLDSWRDEFLIQASPRDPDHFPFVLLGNKVDLESQRAVSSKRAQSWCQTKGNIPYYEVSAKEALNVEAAFLAIARDALARESQETNDFP 187

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BLAST of GTP-binding nuclear protein vs. Ensembl Celegans
Match: rab-5 (RAB family [Source:UniProtKB/TrEMBL;Acc:P91857])

HSP 1 Score: 105.916 bits (263), Expect = 1.662e-27
Identity = 57/164 (34.76%), Postives = 93/164 (56.71%), Query Frame = 1

Query:   85 VAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCE-NIPIVLVGNKVDIKD-RKVKAKTITFHRKKN-LQYYDVSAKSNYNFEKPFLWIARKL 567
              QFKLVL+G+   GK++ V R V G+F +   +T+G              I+F +WDTAGQE++  L   YY   Q AI+++D+T++ +++   NW ++L R    NI + L GNK D+ + R V+ +    + + N L + + SAK++ N    F+ IA+KL
Sbjct:   17 TCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLDDATIKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQESFQKAKNWVKELQRQASPNIVMALAGNKADVANKRTVEYEEANAYAEDNALLFMETSAKTSMNVNDIFMAIAKKL 180

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BLAST of GTP-binding nuclear protein vs. Ensembl Celegans
Match: F11A5.4 (pep chromosome:WBcel235:V:16195679:16196290:1 gene:WBGene00008672.1 transcript:F11A5.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F11A5.4)

HSP 1 Score: 105.531 bits (262), Expect = 1.933e-27
Identity = 63/175 (36.00%), Postives = 103/175 (58.86%), Query Frame = 1

Query:   70 MSGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCE-NIPIVLVGNKVDIK-DRKV-KAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNL 585
            MS D V  FK V++GD G GK+  + R +   F+  + +TLG+E         R K++ +VWDT GQE+F  L   YY     A++++D+TSR ++ ++ +W  DL R+ + +I IVL+GNK D++ DR+V K +   F R+  L + ++SAK+N   E+ F+  A ++    N 
Sbjct:    1 MSSDHV--FKYVIIGDRGVGKSNLLLRFIGKPFDSIHPSTLGIEFGFRNLEIDRKKVKLHVWDTCGQERFRSLVGSYYRHAIGALLVYDITSRESFYHLEHWLTDLQRLGDPDIVIVLIGNKSDLEADREVRKEEGEAFAREFGLIFMEISAKTNEYVEEAFVNSAHEIYRKLNF 173

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BLAST of GTP-binding nuclear protein vs. Ensembl Fly
Match: Ran (gene:FBgn0020255 transcript:FBtr0340164)

HSP 1 Score: 352.829 bits (904), Expect = 5.138e-124
Identity = 165/190 (86.84%), Postives = 174/190 (91.58%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNW 642
             G  +  FK VLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG IRFNVWDTAGQEKFGGLRDGYYIQGQCA+IMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKLVGDPNLEF  MPAL PPEV MD +W
Sbjct:    4 EGQDIPTFKCVLVGDGGTGKTTFVKRHMTGEFEKKYVATLGVEVHPLIFHTNRGAIRFNVWDTAGQEKFGGLRDGYYIQGQCAVIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDPNLEFVAMPALLPPEVKMDKDW 193

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Fly
Match: Ran (gene:FBgn0020255 transcript:FBtr0073471)

HSP 1 Score: 352.829 bits (904), Expect = 5.138e-124
Identity = 165/190 (86.84%), Postives = 174/190 (91.58%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNW 642
             G  +  FK VLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG IRFNVWDTAGQEKFGGLRDGYYIQGQCA+IMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKLVGDPNLEF  MPAL PPEV MD +W
Sbjct:    4 EGQDIPTFKCVLVGDGGTGKTTFVKRHMTGEFEKKYVATLGVEVHPLIFHTNRGAIRFNVWDTAGQEKFGGLRDGYYIQGQCAVIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDPNLEFVAMPALLPPEVKMDKDW 193

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Fly
Match: Ran (gene:FBgn0020255 transcript:FBtr0073472)

HSP 1 Score: 352.829 bits (904), Expect = 5.138e-124
Identity = 165/190 (86.84%), Postives = 174/190 (91.58%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNW 642
             G  +  FK VLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG IRFNVWDTAGQEKFGGLRDGYYIQGQCA+IMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKLVGDPNLEF  MPAL PPEV MD +W
Sbjct:    4 EGQDIPTFKCVLVGDGGTGKTTFVKRHMTGEFEKKYVATLGVEVHPLIFHTNRGAIRFNVWDTAGQEKFGGLRDGYYIQGQCAVIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDPNLEFVAMPALLPPEVKMDKDW 193

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Fly
Match: Ran (gene:FBgn0020255 transcript:FBtr0340165)

HSP 1 Score: 352.829 bits (904), Expect = 5.138e-124
Identity = 165/190 (86.84%), Postives = 174/190 (91.58%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNW 642
             G  +  FK VLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG IRFNVWDTAGQEKFGGLRDGYYIQGQCA+IMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKLVGDPNLEF  MPAL PPEV MD +W
Sbjct:    4 EGQDIPTFKCVLVGDGGTGKTTFVKRHMTGEFEKKYVATLGVEVHPLIFHTNRGAIRFNVWDTAGQEKFGGLRDGYYIQGQCAVIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDPNLEFVAMPALLPPEVKMDKDW 193

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BLAST of GTP-binding nuclear protein vs. Ensembl Fly
Match: Ran-like (gene:FBgn0036497 transcript:FBtr0075616)

HSP 1 Score: 251.521 bits (641), Expect = 5.169e-84
Identity = 117/179 (65.36%), Postives = 141/179 (78.77%), Query Frame = 1

Query:   88 AQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEV 624
            A FKL+L+GDGGTGKTT VKRH+TGEF+ +Y ATLGVEV  L FNT RG  R +VWDTAGQE++GGLRDGY++Q QCAIIMFDV S  TY NV  WHRDLVRVC NIPIV+ GNKVDI  +K   K + F RK N+   ++SAKSNYN EKPF+++ RKLVGDP+L+  + PA+ PP+V
Sbjct:    9 AIFKLILIGDGGTGKTTLVKRHLTGEFKMQYNATLGVEVEQLLFNTNRGVFRIDVWDTAGQERYGGLRDGYFVQSQCAIIMFDVASSNTYNNVKRWHRDLVRVCGNIPIVICGNKVDIMHKKTWKKGVDFDRKTNIYLIEMSAKSNYNVEKPFVYLLRKLVGDPSLQLVQSPAIQPPKV 187

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BLAST of GTP-binding nuclear protein vs. Ensembl Zebrafish
Match: ran (RAN, member RAS oncogene family [Source:NCBI gene;Acc:30572])

HSP 1 Score: 354.755 bits (909), Expect = 1.274e-124
Identity = 164/182 (90.11%), Postives = 174/182 (95.60%), Query Frame = 1

Query:   91 QFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
            QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I++NVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF EMPALAPPE+ MDP
Sbjct:    9 QFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGAIKYNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVEMPALAPPEIAMDP 190

[Close]

Query:   91 QFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
            QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I++NVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF EMPALAPPE+ MDP
Sbjct:    9 QFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGAIKYNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVEMPALAPPEIAMDP 190

[Close]

Query:   91 QFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
            QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I++NVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF EMPALAPPE+ MDP
Sbjct:    9 QFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGAIKYNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVEMPALAPPEIAMDP 190

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Zebrafish
Match: rab7a (RAB7a, member RAS oncogene family [Source:ZFIN;Acc:ZDB-GENE-040426-1352])

HSP 1 Score: 112.464 bits (280), Expect = 9.089e-30
Identity = 56/163 (34.36%), Postives = 92/163 (56.44%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C +++FDVT+  T+K + +W  + +     R  EN P V++GNK+D+++R+V  K        K N+ Y++ SAK   N E+ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVTTKRAQAWCQSKNNIPYFETSAKEAINVEQAFQTIAR 171

[Close]

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C +++FDVT+  T+K + +W  + +     R  EN P V++GNK+D+++R+V  K        K N+ Y++ SAK   N E+ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVTTKRAQAWCQSKNNIPYFETSAKEAINVEQAFQTIAR 171

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Xenopus
Match: ran (RAN, member RAS oncogene family [Source:NCBI gene;Acc:448091])

HSP 1 Score: 354.755 bits (909), Expect = 1.686e-124
Identity = 166/188 (88.30%), Postives = 175/188 (93.09%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             G+   QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    4 QGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 191

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Xenopus
Match: rab7a (RAB7A, member RAS oncogene family [Source:NCBI gene;Acc:493388])

HSP 1 Score: 114.005 bits (284), Expect = 3.488e-30
Identity = 57/163 (34.97%), Postives = 94/163 (57.67%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAK--TITFHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C ++++DVT+  T+K + +W  + +     R  EN P V++GNKVD+++R+V  K   +  H K N+ Y++ SAK   N E+ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFTNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKVDLENRQVTTKRAQVWCHSKNNIPYFETSAKEAINVEQAFQTIAR 171

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Xenopus
Match: rab30 (RAB30, member RAS oncogene family [Source:NCBI gene;Acc:448082])

HSP 1 Score: 108.612 bits (270), Expect = 2.967e-28
Identity = 56/165 (33.94%), Postives = 92/165 (55.76%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCEN-IPIVLVGNKVDIKDRK--VKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDP 579
            FK+VL+G+ G GKT  V+R   G F     AT+GV+           KI+  +WDTAGQE+F  +   YY      I+ +D+T   +++ +P W R++ +   + +  VLVGNK+D+ +R+   + +   F   +N+ Y + SAK + N EK FL +A +L+ + 
Sbjct:   10 FKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEIKGEKIKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYANSEVITVLVGNKIDLAERREVSQQRAEEFAGTQNMYYLETSAKESDNVEKLFLDLACRLISEA 174

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BLAST of GTP-binding nuclear protein vs. Ensembl Xenopus
Match: rab5a (RAB5A, member RAS oncogene family [Source:NCBI gene;Acc:493430])

HSP 1 Score: 105.916 bits (263), Expect = 4.588e-27
Identity = 55/168 (32.74%), Postives = 93/168 (55.36%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCE-NIPIVLVGNKVDIKDRKVK--AKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKL 567
            +G+ + QFKLVL+G+   GK++ V R V G+F +   +T+G              ++F +WDTAGQE++  L   YY   Q AI+++D+T+  ++    NW ++L R    NI I L GNK D+  ++     +   +    +L + + SAK++ N  + F+ IA+KL
Sbjct:   15 AGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADLASKRAVDFQEAQAYADDNSLLFMETSAKTSVNVNEIFMAIAKKL 182

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BLAST of GTP-binding nuclear protein vs. Ensembl Xenopus
Match: vasp (vasodilator stimulated phosphoprotein [Source:Xenbase;Acc:XB-GENE-6454542])

HSP 1 Score: 105.531 bits (262), Expect = 4.807e-27
Identity = 53/167 (31.74%), Postives = 90/167 (53.89%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDL-----VRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQ--YYDVSAKSNYNFEKPFLWIARKLVG 573
             K++L+GDGG GK++ + R+VT +F+ +   T+GVE    E       +   +WDTAGQE+F  LR  +Y    C ++ F V    +++N+ NW ++      V+  ++ P V++GNK+DI DR+V  +      + N    Y++ SAK   N    F    R+++ 
Sbjct:    8 LKIILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKELEVDGHLVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLTNWKKEFIYYADVKDPDSFPFVILGNKIDITDRQVSVEEAQAWCRDNGNNPYFETSAKDATNVAAAFEEAVRRVLA 174

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Mouse
Match: Ran (RAN, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1333112])

HSP 1 Score: 354.755 bits (909), Expect = 1.735e-124
Identity = 166/188 (88.30%), Postives = 175/188 (93.09%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             G+   QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    4 QGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 191

[Close]

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             G+   QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    4 QGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 191

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Mouse
Match: 1700009N14Rik (RIKEN cDNA 1700009N14 gene [Source:MGI Symbol;Acc:MGI:1922721])

HSP 1 Score: 344.739 bits (883), Expect = 1.274e-120
Identity = 162/188 (86.17%), Postives = 172/188 (91.49%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             GD   QFKLVLVGDGGTGKT FVKRH+TGEFEKKYVATLGVEVHPL F+T+RG I+FNVWDTAGQEKFGGLRDGYYIQ Q AIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVL GNKVD+KDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW++R+L GD NLEF  MPALAPPEV MDP
Sbjct:    4 EGDPPVQFKLVLVGDGGTGKTAFVKRHLTGEFEKKYVATLGVEVHPLMFHTSRGPIKFNVWDTAGQEKFGGLRDGYYIQAQGAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLSRRLTGDSNLEFVAMPALAPPEVVMDP 191

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Mouse
Match: Rasl2-9 (RAS-like, family 2, locus 9 [Source:MGI Symbol;Acc:MGI:104605])

HSP 1 Score: 337.421 bits (864), Expect = 1.105e-117
Identity = 156/188 (82.98%), Postives = 171/188 (90.96%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             G+   QFK+VLVGDGGTGKTTF+KRH+TGEFEK+YVATLGVEVH L F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVP+WH+DLVRVCENIPIVL GNKVD+KD KVKAK I FHRKKNLQYYD+SA+SNYNFEKPF W+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    4 QGEPQVQFKVVLVGDGGTGKTTFMKRHLTGEFEKEYVATLGVEVHTLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPSWHKDLVRVCENIPIVLCGNKVDVKDMKVKAKPILFHRKKNLQYYDISARSNYNFEKPFFWLARKLIGDPNLEFVAMPALAPPEVVMDP 191

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Mouse
Match: Rab7 (RAB7, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:105068])

HSP 1 Score: 112.464 bits (280), Expect = 9.705e-30
Identity = 56/163 (34.36%), Postives = 93/163 (57.06%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C +++FDVT+  T+K + +W  + +     R  EN P V++GNK+D+++R+V  K      + K N+ Y++ SAK   N E+ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIAR 171

[Close]

BLAST of GTP-binding nuclear protein vs. UniProt/SwissProt
Match: sp|P38542|RAN_BRUMA (GTP-binding nuclear protein Ran OS=Brugia malayi OX=6279 GN=Bm1_44725 PE=2 SV=2)

HSP 1 Score: 362.073 bits (928), Expect = 1.221e-126
Identity = 169/191 (88.48%), Postives = 180/191 (94.24%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWV 645
            +GD +  FKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG+IRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVT+R+TYKNVPNWHRDLVRVCENIPIVL GNKVD+KDRKVKAKTITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP  V
Sbjct:    3 TGDDIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLIFHTNRGQIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTARVTYKNVPNWHRDLVRVCENIPIVLCGNKVDVKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLLGDPNLEFVAMPALAPPEVQMDPTMV 193

[Close]

BLAST of GTP-binding nuclear protein vs. UniProt/SwissProt
Match: sp|O17915|RAN_CAEEL (GTP-binding nuclear protein ran-1 OS=Caenorhabditis elegans OX=6239 GN=ran-1 PE=1 SV=1)

HSP 1 Score: 358.992 bits (920), Expect = 2.273e-125
Identity = 167/191 (87.43%), Postives = 178/191 (93.19%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWV 645
             GD +  FKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG+IRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVT+R+TYKNVPNWHRDL RVCENIPIVL GNKVD+KDRKVKAKTITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP  +
Sbjct:    3 GGDGIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGQIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTARVTYKNVPNWHRDLARVCENIPIVLCGNKVDVKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLLGDPNLEFVAMPALAPPEVQMDPAMI 193

[Close]

BLAST of GTP-binding nuclear protein vs. UniProt/SwissProt
Match: sp|P52301|RAN_XENLA (GTP-binding nuclear protein Ran OS=Xenopus laevis OX=8355 GN=ran PE=1 SV=2)

HSP 1 Score: 354.755 bits (909), Expect = 8.738e-124
Identity = 166/188 (88.30%), Postives = 175/188 (93.09%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             G+   QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    4 QGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 191

[Close]

BLAST of GTP-binding nuclear protein vs. UniProt/SwissProt
Match: sp|P42558|RAN_CHICK (GTP-binding nuclear protein Ran OS=Gallus gallus OX=9031 GN=RAN PE=2 SV=1)

HSP 1 Score: 354.755 bits (909), Expect = 8.738e-124
Identity = 166/188 (88.30%), Postives = 175/188 (93.09%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
             G+   QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP
Sbjct:    4 QGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDP 191

[Close]

BLAST of GTP-binding nuclear protein vs. UniProt/SwissProt
Match: sp|P79735|RAN_DANRE (GTP-binding nuclear protein Ran OS=Danio rerio OX=7955 GN=ran PE=2 SV=1)

HSP 1 Score: 354.755 bits (909), Expect = 9.620e-124
Identity = 164/182 (90.11%), Postives = 174/182 (95.60%), Query Frame = 1

Query:   91 QFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
            QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I++NVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF EMPALAPPE+ MDP
Sbjct:    9 QFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGAIKYNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVEMPALAPPEIAMDP 190

[Close]

BLAST of GTP-binding nuclear protein vs. TrEMBL
Match: A0A267GL75 (GTP-binding nuclear protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig010089g1 PE=3 SV=1)

HSP 1 Score: 365.925 bits (938), Expect = 1.287e-125
Identity = 170/187 (90.91%), Postives = 182/187 (97.33%), Query Frame = 1

Query:   79 DAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPN 639
            + +AQFKLVLVGDGG GKTTFVKRH+TGEFEKKYVATLGVEVHPL+F+TTRGK+RFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKLVGD +LEF EMPALAPPE+ MDP+
Sbjct:   11 NVIAQFKLVLVGDGGVGKTTFVKRHLTGEFEKKYVATLGVEVHPLDFHTTRGKMRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDAHLEFVEMPALAPPELAMDPS 197

[Close]

BLAST of GTP-binding nuclear protein vs. TrEMBL
Match: A0A267G1T7 (GTP-binding nuclear protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig012914g2 PE=3 SV=1)

HSP 1 Score: 365.925 bits (938), Expect = 1.312e-125
Identity = 170/187 (90.91%), Postives = 182/187 (97.33%), Query Frame = 1

Query:   79 DAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPN 639
            + +AQFKLVLVGDGG GKTTFVKRH+TGEFEKKYVATLGVEVHPL+F+TTRGK+RFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKLVGD +LEF EMPALAPPE+ MDP+
Sbjct:   10 NVIAQFKLVLVGDGGVGKTTFVKRHLTGEFEKKYVATLGVEVHPLDFHTTRGKMRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDAHLEFVEMPALAPPELAMDPS 196

[Close]

BLAST of GTP-binding nuclear protein vs. TrEMBL
Match: A0A1I8HZD4 (GTP-binding nuclear protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 364.77 bits (935), Expect = 2.789e-125
Identity = 170/187 (90.91%), Postives = 182/187 (97.33%), Query Frame = 1

Query:   79 DAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPN 639
            + +AQFKLVLVGDGG GKTTFVKRH+TGEFEKKYVATLGVEVHPL+F+TTRGK+RFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKLVGD +LEF EMPALAPPE+ MDP+
Sbjct:    5 NVIAQFKLVLVGDGGVGKTTFVKRHLTGEFEKKYVATLGVEVHPLDFHTTRGKMRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDAHLEFVEMPALAPPELAMDPS 191

[Close]

BLAST of GTP-binding nuclear protein vs. TrEMBL
Match: A0A0N5CX98 (GTP-binding nuclear protein OS=Thelazia callipaeda OX=103827 GN=TCLT_LOCUS5001 PE=3 SV=1)

HSP 1 Score: 363.229 bits (931), Expect = 1.442e-124
Identity = 169/191 (88.48%), Postives = 181/191 (94.76%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWV 645
            SGD +  FKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG+IRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVT+R+TYKNVPNWHRDLVRVCENIPIVL GNKVD+KDRKVKAKTITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP+ +
Sbjct:    3 SGDDIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLIFHTNRGQIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTARVTYKNVPNWHRDLVRVCENIPIVLCGNKVDVKDRKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLLGDPNLEFVAMPALAPPEVQMDPSMI 193

[Close]

BLAST of GTP-binding nuclear protein vs. TrEMBL
Match: A0A4Z2DXJ0 (GTP-binding nuclear protein OS=Schistosoma japonicum OX=6182 GN=EWB00_001699 PE=3 SV=1)

HSP 1 Score: 363.229 bits (931), Expect = 1.527e-124
Identity = 169/187 (90.37%), Postives = 181/187 (96.79%), Query Frame = 1

Query:   85 VAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWV 645
            VA FKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL+F+TTRGK+RFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDI+DRKVKAK+ITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKLVGDPNLEF EMPA+ PPE+ +DPN V
Sbjct:    7 VAVFKLVLVGDGGTGKTTFVKRHITGEFEKKYVATLGVEVHPLDFHTTRGKMRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIQDRKVKAKSITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGDPNLEFVEMPAMEPPEIQIDPNLV 193

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Cavefish
Match: ran (RAN, member RAS oncogene family [Source:NCBI gene;Acc:103033763])

HSP 1 Score: 356.295 bits (913), Expect = 2.409e-125
Identity = 165/187 (88.24%), Postives = 176/187 (94.12%), Query Frame = 1

Query:   79 DAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPN 639
            D   QFKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I++NVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF EMPALAPPE+ MDP+
Sbjct:    5 DPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGAIKYNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVEMPALAPPEIAMDPS 191

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Cavefish
Match: rab7a (ras-related protein rab7 [Source:NCBI gene;Acc:103043048])

HSP 1 Score: 112.464 bits (280), Expect = 7.703e-30
Identity = 56/163 (34.36%), Postives = 92/163 (56.44%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C +++FDVT+  T+K + +W  + +     R  EN P V++GNK+D+++R+V  K        K N+ Y++ SAK   N E+ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVTTKRAQAWCQSKNNIPYFETSAKEAINVEQAFQTIAR 171

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Cavefish
Match: ENSAMXT00000041258.1 (RAB7A, member RAS oncogene family [Source:NCBI gene;Acc:103037857])

HSP 1 Score: 111.309 bits (277), Expect = 2.216e-29
Identity = 54/163 (33.13%), Postives = 92/163 (56.44%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C ++++DVT+  T+K + +W  + +     R  +N P V++GNK+D+++R+V  K        K N+ Y++ SAK   N E+ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVEDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVTAPTTFKTLDSWRDEFLIQASPRDPDNFPFVVLGNKIDLENRQVTTKRAQAWCQSKNNMPYFETSAKEAINVEQAFQTIAR 171

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Cavefish
Match: rab7b (ras-related protein rab7-like [Source:NCBI gene;Acc:103037223])

HSP 1 Score: 110.153 bits (274), Expect = 4.906e-29
Identity = 54/163 (33.13%), Postives = 92/163 (56.44%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C ++++DVT+  T+K + +W  + +     R  EN P V++GNK+D+++R+V  K        K N+ Y++ SAK   N ++ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNNKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVTTKRAQAWCQSKNNIPYFETSAKEAINVDQAFQTIAR 171

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Cavefish
Match: ENSAMXT00000002303.2 (RAB7A, member RAS oncogene family [Source:NCBI gene;Acc:103037857])

HSP 1 Score: 110.153 bits (274), Expect = 6.674e-29
Identity = 54/163 (33.13%), Postives = 92/163 (56.44%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C ++++DVT+  T+K + +W  + +     R  +N P V++GNK+D+++R+V  K        K N+ Y++ SAK   N E+ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVEDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVTAPTTFKTLDSWRDEFLIQASPRDPDNFPFVVLGNKIDLENRQVTTKRAQAWCQSKNNMPYFETSAKEAINVEQAFQTIAR 171

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Sea Lamprey
Match: ran (RAN, member RAS oncogene family [Source:NCBI gene;Acc:30572])

HSP 1 Score: 295.434 bits (755), Expect = 1.784e-102
Identity = 137/154 (88.96%), Postives = 143/154 (92.86%), Query Frame = 1

Query:  184 ATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWV 645
            ATLGVEVHPL F+T RG I+FNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDP  V
Sbjct:    1 ATLGVEVHPLVFHTNRGAIKFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKAIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVQMDPQLV 154

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Sea Lamprey
Match: rab30 (RAB30, member RAS oncogene family [Source:ZFIN;Acc:ZDB-GENE-040718-250])

HSP 1 Score: 115.546 bits (288), Expect = 1.097e-31
Identity = 68/183 (37.16%), Postives = 103/183 (56.28%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVE--VHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVR-VCENIPIVLVGNKVDIKD-RKV-KAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVP 627
            FK+VL+G+ G GKT  V+R   G F     AT+GV+  +  +E + T  KI+  +WDTAGQE+F  +   YY      ++ +DV+S  T+  +P W R++ +    ++P VLVGNK+D+ D R+V + +   F R   L+Y + SAK   N E+ F+ +AR+L  D     A  PAL     P
Sbjct:   10 FKIVLIGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEVDGT--KIKLQIWDTAGQERFRSITQSYYRSAHALVLTYDVSSEETFACLPAWLREMEQHASAHVPRVLVGNKLDLADVRQVTREQAEAFARLHGLRYLETSAKEAENVERLFVELARRLALD-----ARQPALGDAPGP 185

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Sea Lamprey
Match: rab5c (RAB5C, member RAS oncogene family [Source:ZFIN;Acc:ZDB-GENE-031118-30])

HSP 1 Score: 107.071 bits (266), Expect = 1.821e-28
Identity = 58/174 (33.33%), Postives = 96/174 (55.17%), Query Frame = 1

Query:   67 KMSGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCE-NIPIVLVGNKVDIKDRKVKAKTITFHRKK------NLQYYDVSAKSNYNFEKPFLWIARKL 567
            +++G+ + QFKLVL+G+   GK++ V R V G+F +   +T+G              ++F +WDTAGQE++  L   YY   Q AI+++D+T++ ++    NW ++L R    NI I L GNK D+ ++    +T+ F   +       L + + SAK+  N    FL IA+KL
Sbjct:   13 QVAGNKMCQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLEDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQDSFARAKNWVKELQRQANPNIVIALAGNKTDLANQ----RTVDFEEAQGYSEDNGLLFMETSAKTAMNVNDVFLAIAKKL 182

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000009.1 (pep scaffold:Pmarinus_7.0:GL476426:408368:444599:1 gene:ENSPMAG00000000008.1 transcript:ENSPMAT00000000009.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 104.375 bits (259), Expect = 2.206e-27
Identity = 56/168 (33.33%), Postives = 90/168 (53.57%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCE-NIPIVLVGNKVDIKDRKVK--AKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKL 567
            S   + QFKLVL+G+   GK++ V R V G+F +   +T+G              ++F +WDTAGQE++  L   YY   Q AI+++D+T++ T+     W ++L R    NI I L GNK D+  +++    +  ++     L + + SAK+  N    FL IA+KL
Sbjct:   20 STSKILQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVCLEDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQDTFSRAKTWVKELQRQASPNIVIALAGNKADLASKRIVEFEEAQSYADDNGLLFMETSAKTAMNVNDIFLAIAKKL 187

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Sea Lamprey
Match: rab5c (RAB5C, member RAS oncogene family [Source:ZFIN;Acc:ZDB-GENE-031118-30])

HSP 1 Score: 102.064 bits (253), Expect = 1.669e-26
Identity = 65/197 (32.99%), Postives = 105/197 (53.30%), Query Frame = 1

Query:   55 NCFKKMSGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCE-NIPIVLVGNKVDI-KDRKVKAKTITFHRKKN-LQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDP 636
            NC  + + + + QFKLVL+G+   GK++ V R V G+F +   +T+G        +     ++F +WDTAGQE++  L   YY   Q AI+++D+T+  ++     W ++L R     I I L GNK D+   R V+ +    + ++N L + + SAK+  N  + FL IA+KL   P  E  + P      VP+DP
Sbjct:   11 NC--QTATNKMCQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVSLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNLDSFARAKTWVKELQRQANPTIVIALSGNKADLASQRMVEFEEAQGYAEENGLLFMETSAKTAMNVNEVFLAIAKKL---PKNE-QQNPGGKSNVVPIDP 201

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Yeast
Match: GSP2 (GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); not required for viability; protein abundance increases in response to DNA replication stress; GSP2 has a paralog, GSP1, that arose from the whole genome duplication [Source:SGD;Acc:S000005711])

HSP 1 Score: 333.954 bits (855), Expect = 3.269e-117
Identity = 156/183 (85.25%), Postives = 168/183 (91.80%), Query Frame = 1

Query:   85 VAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMD 633
            V  FKLVLVGDGGTGKTTFVKRH+TGEFEKKY+AT+GVEVHPL F T  G+I+F+VWDTAGQEKFGGLRDGYYI  QCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVL GNKVD+K+RKVKAKTITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL G+P LEF   PALAPPEV +D
Sbjct:   11 VPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVD 193

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Yeast
Match: GSP1 (Ran GTPase; GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; GSP1 has a paralog, GSP2, that arose from the whole genome duplication [Source:SGD;Acc:S000004284])

HSP 1 Score: 333.183 bits (853), Expect = 5.577e-117
Identity = 156/183 (85.25%), Postives = 168/183 (91.80%), Query Frame = 1

Query:   85 VAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMD 633
            V  FKLVLVGDGGTGKTTFVKRH+TGEFEKKY+AT+GVEVHPL F T  G+I+F+VWDTAGQEKFGGLRDGYYI  QCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVL GNKVD+K+RKVKAKTITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL G+P LEF   PALAPPEV +D
Sbjct:   10 VPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQLEFVASPALAPPEVQVD 192

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Yeast
Match: YPT6 (Rab family GTPase; required for endosome-to-Golgii, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6 [Source:SGD;Acc:S000004252])

HSP 1 Score: 96.6709 bits (239), Expect = 1.145e-24
Identity = 58/185 (31.35%), Postives = 97/185 (52.43%), Query Frame = 1

Query:   73 SGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDL--VRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQ----YYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPAL 609
            SG ++ ++K+V +G+ G GKT+ + R +   F+  Y AT+G++            IR  +WDTAGQE+F  L   Y    + AII++D+T R +++ +  W  D+   R  EN+ + +VGNK D+ D + +  T    +K  L     + + S K+ YN +  F  IA+ L   P  + +E   L
Sbjct:    4 SGKSLTKYKIVFLGEQGVGKTSLITRFMYDTFDDHYQATIGIDFLSKTMYLDDKTIRLQLWDTAGQERFRSLIPSYIRDSRVAIIVYDITKRKSFEYIDKWIEDVKNERGDENVILCIVGNKSDLSDER-QISTEEGEKKAKLLGAKIFMETSTKAGYNVKALFKKIAKSL---PEFQNSESTPL 184

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Yeast
Match: VPS21 (Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication [Source:SGD;Acc:S000005615])

HSP 1 Score: 95.1301 bits (235), Expect = 3.569e-24
Identity = 54/168 (32.14%), Postives = 90/168 (53.57%), Query Frame = 1

Query:   82 AVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDL-VRVCENIPIVLVGNKVDI----KDRKV-KAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKL 567
            +V   KLVL+G+   GK++ V R V+ +F +    T+G              ++F +WDTAGQE+F  L   YY   Q A++++DVT   ++    +W ++L  +  ++I I LVGNK+D+     +RKV + +      +K L +++ SAK+  N    FL I  K+
Sbjct:    4 SVTSIKLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAFLTQRVTINEHTVKFEIWDTAGQERFASLAPMYYRNAQAALVVYDVTKPQSFIKARHWVKELHEQASKDIIIALVGNKIDMLQEGGERKVAREEGEKLAEEKGLLFFETSAKTGENVNDVFLGIGEKI 171

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Yeast
Match: YPT53 (Stress-induced Rab family GTPase; required for vacuolar protein sorting and endocytosis; involved in ionic stress tolerance; similar to Vps21p and Ypt52p; functional homolog of Vps21p; mammalian Rab5 homolog; YPT53 has a paralog, VPS21, that arose from the whole genome duplication [Source:SGD;Acc:S000005037])

HSP 1 Score: 94.7449 bits (234), Expect = 6.598e-24
Identity = 55/167 (32.93%), Postives = 91/167 (54.49%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDL-VRVCENIPIVLVGNKVDI-------KDRKVKAKTI-TFHRKKNLQYYDVSAKSNYNFEKPFLWIARKL 567
             K+VL+G+   GK++ V R V+ +F++    T+G              I+F +WDTAGQE+F  L   YY   Q A+++FDVT+  ++    NW  +L  +V  +I I LVGNK+D+       ++R +KA  +     ++NL Y++ SAK+  N  + F  +  K+
Sbjct:   13 IKVVLLGESAVGKSSIVLRFVSDDFKESKEPTIGAAFLTKRITRDGKVIKFEIWDTAGQERFAPLAPMYYRNAQAALVVFDVTNEGSFYKAQNWVEELHEKVGHDIVIALVGNKMDLLNNDDENENRAMKAPAVQNLCERENLLYFEASAKTGENIYQIFQTLGEKV 179

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Nematostella
Match: EDO37375 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SG05])

HSP 1 Score: 355.525 bits (911), Expect = 2.170e-125
Identity = 168/185 (90.81%), Postives = 175/185 (94.59%), Query Frame = 1

Query:   85 VAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPN 639
            VA FKLVLVGDGGTGKTTFVKRH+TGEFEKKY+ATLGVEVHPL F T+RG I+FNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSR+TYKNVPNWHRDL RVCENIPIVL GNKVDIKDRKVKAK ITFHRKKNLQYYD+SAKSNYNFEKPFLW+ARKLVGDPNLEF EMPAL PPEV MDPN
Sbjct:    8 VATFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLIFFTSRGPIKFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRVTYKNVPNWHRDLERVCENIPIVLCGNKVDIKDRKVKAKAITFHRKKNLQYYDLSAKSNYNFEKPFLWLARKLVGDPNLEFVEMPALQPPEVQMDPN 192

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Nematostella
Match: EDO45332 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RT62])

HSP 1 Score: 111.694 bits (278), Expect = 4.536e-30
Identity = 55/167 (32.93%), Postives = 93/167 (55.69%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVG 573
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C +++FDVT   ++K + +W  + +     R  EN P V++GNK+D+++R V AK      H K ++ Y++ SAK   N E+ F  IA+  + 
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTQPNSFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRAVSAKRAQAWCHSKNDIPYFETSAKEAINVEQAFQTIAKNALA 175

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Nematostella
Match: EDO43734 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXW7])

HSP 1 Score: 111.309 bits (277), Expect = 9.385e-30
Identity = 54/156 (34.62%), Postives = 89/156 (57.05%), Query Frame = 1

Query:   79 DAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPF 546
            D     K++ +GD   GK+  V+R +   ++ + ++T  + +   E       IR + WDTAGQE+F  +   YY Q    +++FD+T +ITYKN+ NW+++L +  ++IP ++V NK+D+ D KV  K+  F +K  L +Y VSA    N  K F
Sbjct:   20 DKETSVKVICLGDSAVGKSKLVERFLMDGYKPQQLSTYALTLFHYETKVDDKDIRVDFWDTAGQERFSSMHPSYYHQAHACLLVFDITRKITYKNLANWYKELRKYRDSIPCIVVANKIDV-DYKVTQKSFNFPKKYGLPFYFVSASDGTNVVKVF 174

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Nematostella
Match: EDO44528 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RV85])

HSP 1 Score: 107.071 bits (266), Expect = 2.938e-28
Identity = 57/166 (34.34%), Postives = 91/166 (54.82%), Query Frame = 1

Query:   70 MSGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKV--KAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
            M+ D    FKL+++GD G GK++ + R     F   Y+ T+GV+      N    K++  +WDTAGQE+F  +   YY      I+++DVTS  T+ NV  W  ++ + C+++  +LVGNK D   +KV   A    F  + N++ ++ SAK N N E+ F  I +
Sbjct:    1 MARDYDHLFKLLIIGDSGVGKSSLLLRFADNMFSGSYITTIGVDFKIRTINIDGEKVKLQIWDTAGQERFRTITSTYYRGTHGVIVVYDVTSADTFVNVKRWLHEIDQNCDDVIRILVGNKDDCPSKKVVETADLQKFGEQMNIRVFETSAKENINVEEIFSSITK 166

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Nematostella
Match: EDO40980 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5I3])

HSP 1 Score: 106.686 bits (265), Expect = 4.249e-28
Identity = 50/166 (30.12%), Postives = 95/166 (57.23%), Query Frame = 1

Query:   79 DAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-RVCENIPIVLVGNKVDIKDRKV--KAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKL 567
            D  A +K++++GD G GKT  + R     F   Y++T+G++      +    +IR  +WDTAGQE+F  L   YY      ++++D+T+  ++K++  W +++      N+  VL+GNK+D +D +V    +  +     NL++Y+ SA++  N ++ F+ +ARK+
Sbjct:   12 DFEATYKILVLGDSGVGKTCLIFRFAEDIFSDSYISTIGIDCRSRVVDLDGQRIRLQIWDTAGQERFRTLTSAYYRGAMGILLVYDITTEDSFKHISQWLQNIEDNASPNVCKVLLGNKLDAEDERVIDAQRGRSVGEDNNLEFYEASARTGENVQQAFMAVARKI 177

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Medaka
Match: ran (RAN, member RAS oncogene family [Source:NCBI gene;Acc:101156259])

HSP 1 Score: 355.525 bits (911), Expect = 5.743e-125
Identity = 166/185 (89.73%), Postives = 175/185 (94.59%), Query Frame = 1

Query:   85 VAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPN 639
            VA FKLVLVGDGGTGKTTFVKRH+TGEFEKKYVATLGVEVHPL F+T RG I++NVWDTAGQEKFGGLRDGYYIQ QCAIIMFDVTSR+TYKNVPNWHRDLVRVCENIPIVL GNKVDIKDRKVKAK+I FHRKKNLQYYD+SAKSNYNFEKPFLW+ARKL+GDPNLEF  MPALAPPEV MDPN
Sbjct:   11 VAVFKLVLVGDGGTGKTTFVKRHITGEFEKKYVATLGVEVHPLMFHTNRGPIKYNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVLMDPN 195

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Medaka
Match: rab7a (ras-related protein rab7 [Source:NCBI gene;Acc:101157689])

HSP 1 Score: 112.464 bits (280), Expect = 6.786e-30
Identity = 56/163 (34.36%), Postives = 92/163 (56.44%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C +++FDVT+  T+K + +W  + +     R  EN P V++GNK+D+++R+V  K        K N+ Y++ SAK   N E+ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVTTKRAQAWCQSKNNIPYFETSAKEAINVEQAFQTIAR 171

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Medaka
Match: ENSORLT00000021125.2 (RAB7A, member RAS oncogene family [Source:NCBI gene;Acc:101157360])

HSP 1 Score: 112.464 bits (280), Expect = 7.338e-30
Identity = 56/163 (34.36%), Postives = 92/163 (56.44%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
             K++++GD G GKT+ + ++V  +F  +Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C +++FDVT+  T+K + +W  + +     R  EN P V++GNK+D+++R+V  K        K N+ Y++ SAK   N E+ F  IAR
Sbjct:    9 LKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVTTKRAQAWCQSKNNIPYFETSAKEAINVEQAFQTIAR 171

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Medaka
Match: rab10 (RAB10, member RAS oncogene family [Source:NCBI gene;Acc:101173671])

HSP 1 Score: 108.612 bits (270), Expect = 2.060e-28
Identity = 56/173 (32.37%), Postives = 100/173 (57.80%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDL-VRVCENIPIVLVGNKVDIKDRKV--KAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKL-----VGDPNLE 588
            FKL+L+GD G GKT  + R     F   +++T+G++           KI+  +WDTAGQE+F  +   YY      ++++D+++  +++N+  W R++     E++  +L+GNK D++D++V  KAK     R+  +++++ SAK+N N EK FL +A  +     V +PN E
Sbjct:   10 FKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQERFHTITTSYYRGAMGIMLVYDISNTKSFENISKWLRNIDEHANEDVERMLLGNKCDMEDKRVVPKAKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDILKKTPVKEPNSE 182

[Close]

BLAST of GTP-binding nuclear protein vs. Ensembl Medaka
Match: zgc:171927 (ras-related protein ORAB-1-like [Source:NCBI gene;Acc:101173484])

HSP 1 Score: 107.071 bits (266), Expect = 9.495e-28
Identity = 55/161 (34.16%), Postives = 89/161 (55.28%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVR-VCENIPIVLVGNKVDIKDRKV--KAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKL 567
            FKL+L+GD G GK+  + R     + + Y++T+GV+      +     ++  +WDTAGQE+F  +   YY      II++DVT + ++ NV  W  ++ R  CEN+  +LVGNK D+  +KV   A          + + + SAKS+ N EK FL +A ++
Sbjct:    9 FKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIDMDGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDVTEQESFNNVRQWLEEIDRYACENVSRLLVGNKSDLVSKKVVDAATAQDLASSLKIPFLETSAKSSGNVEKAFLTMASEI 169

[Close]

BLAST of GTP-binding nuclear protein vs. Planmine SMEST
Match: SMESG000072522.1 (SMESG000072522.1)

HSP 1 Score: 401.364 bits (1030), Expect = 2.767e-143
Identity = 192/192 (100.00%), Postives = 192/192 (100.00%), Query Frame = 1

Query:   70 MSGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWV 645
            MSGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWV
Sbjct:    1 MSGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWV 192

[Close]

BLAST of GTP-binding nuclear protein vs. Planmine SMEST
Match: SMESG000031968.1 (SMESG000031968.1)

HSP 1 Score: 103.219 bits (256), Expect = 1.779e-26
Identity = 49/150 (32.67%), Postives = 82/150 (54.67%), Query Frame = 1

Query:   97 KLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAKSNYNFEKPF 546
            K++ +GD   GK+  V+R +   ++ + ++T  + +   + N    K+  + WDTAGQE++  +   YY Q    I++FDVT +ITYKN+ NW+++L     +IP + V NK+D  D     ++  F  K  + +Y VSA    N  K F
Sbjct:   19 KIICLGDSAVGKSKLVERFLMDGYQPQQLSTYALTLFKYQTNLDGKKLTVDFWDTAGQERYQSMHTSYYYQAHACILVFDVTRKITYKNLDNWYKELREHRPDIPCICVANKID-ADMSATKRSFKFPTKNKMPFYFVSASDGTNVVKAF 167

[Close]

BLAST of GTP-binding nuclear protein vs. Planmine SMEST
Match: SMESG000051108.1 (SMESG000051108.1)

HSP 1 Score: 102.834 bits (255), Expect = 2.532e-26
Identity = 56/163 (34.36%), Postives = 93/163 (57.06%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVCE-NIPIVLVGNKVDIKDRK----VKAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKL 567
            FK+VL+GD G GKT  V+R  +G F +K  +T+GV+           K++  +WDTAGQE+F  +   YY      I+ +D+T R ++ NV +W  D+ +    NI  +L+GNK D+ +++     +A+ +  HR   L   + SA+ N N ++ F+ +AR+L
Sbjct:   13 FKIVLIGDAGVGKTCVVQRFKSGNFLEKNGSTIGVDFTMKTVVVDGKKVKLQIWDTAGQERFRTITQSYYRSANGVIVAYDITKRESFNNVLHWLEDIKKYAGPNILQILIGNKKDLDEQREVKFTEAQDLA-HRCNMLDSLETSAQENSNIDEVFMKLAREL 174

[Close]

BLAST of GTP-binding nuclear protein vs. Planmine SMEST
Match: SMESG000075649.1 (SMESG000075649.1)

HSP 1 Score: 102.834 bits (255), Expect = 2.551e-26
Identity = 50/163 (30.67%), Postives = 87/163 (53.37%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLV-----RVCENIPIVLVGNKVDIKDRKVKAKTIT--FHRKKNLQYYDVSAKSNYNFEKPFLWIAR 561
            FK++++GD G GKT+ + ++V   F   Y AT+G +    E       +   +WDTAGQE+F  L   +Y    C I+++DV+   T+KN+ +W  + +        E  P V++GNK+D+ +R+V  +T         ++ Y++ SAK   N +  F+  A+
Sbjct:   14 FKIIILGDSGVGKTSLLNQYVNKRFNTVYKATIGSDFQAKEVEINEHIVTLQIWDTAGQERFQSLGIAFYRGADCCILVYDVSRIDTFKNLNSWKEEFILQANLTAVEGFPFVVIGNKIDLDNRQVTLRTAQQWCLTNDDIAYFETSAKDAINVDNAFIKAAQ 176

[Close]

BLAST of GTP-binding nuclear protein vs. Planmine SMEST
Match: SMESG000049854.1 (SMESG000049854.1)

HSP 1 Score: 102.449 bits (254), Expect = 3.206e-26
Identity = 51/161 (31.68%), Postives = 88/161 (54.66%), Query Frame = 1

Query:   94 FKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEFNTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVPNWHRDLVRVC-ENIPIVLVGNKVDIKDRKV--KAKTITFHRKKNLQYYDVSAKSNYNFEKPFLWIARKL 567
            FKL+L+GD G GK+  + R     +   Y++T+GV+            ++  +WDTAGQE+F  +   YY      I+++DVT + ++ NV NW  ++ R   EN+  +L+GNK D+  +KV        F    N+ + + SA+ + N EK F+ +A+++
Sbjct:    9 FKLLLIGDSGVGKSCILLRFADDTYTDSYISTIGVDFKIRTIELDGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQTSFNNVKNWLNEIERYANENVNKLLIGNKSDMVSKKVVDSGTAKEFADSLNIPFLETSARDSTNVEKTFITMAQEI 169

The following BLAST results are available for this feature:

BLAST of GTP-binding nuclear protein vs. Ensembl Human
BLAST of GTP-binding nuclear protein vs. Ensembl Celegans
BLAST of GTP-binding nuclear protein vs. Ensembl Fly
BLAST of GTP-binding nuclear protein vs. Ensembl Zebrafish
BLAST of GTP-binding nuclear protein vs. Ensembl Xenopus
BLAST of GTP-binding nuclear protein vs. Ensembl Mouse
BLAST of GTP-binding nuclear protein vs. UniProt/SwissProt
BLAST of GTP-binding nuclear protein vs. TrEMBL
BLAST of GTP-binding nuclear protein vs. Ensembl Cavefish
BLAST of GTP-binding nuclear protein vs. Ensembl Sea Lamprey
BLAST of GTP-binding nuclear protein vs. Ensembl Yeast
BLAST of GTP-binding nuclear protein vs. Ensembl Nematostella
BLAST of GTP-binding nuclear protein vs. Ensembl Medaka
BLAST of GTP-binding nuclear protein vs. Planmine SMEST

BLAST of GTP-binding nuclear protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
RAN	2.527e-124	88.30	RAN, member RAS oncogene family [Source:HGNC Symbo...	[more]
RAN	2.527e-124	88.30	RAN, member RAS oncogene family [Source:HGNC Symbo...	[more]
RAN	1.629e-121	84.92	RAN, member RAS oncogene family [Source:HGNC Symbo...	[more]
RAN	2.766e-121	88.11	RAN, member RAS oncogene family [Source:HGNC Symbo...	[more]
RAN	2.620e-120	80.98	RAN, member RAS oncogene family [Source:HGNC Symbo...	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ran-1	1.787e-126	87.43	GTP-binding nuclear protein ran-1 [Source:UniProt...	[more]
rab-7	6.022e-31	33.89	RAB family [Source:UniProtKB/TrEMBL;Acc:Q23146]	[more]
rab-7	6.022e-31	33.89	RAB family [Source:UniProtKB/TrEMBL;Acc:Q23146]	[more]
rab-5	1.662e-27	34.76	RAB family [Source:UniProtKB/TrEMBL;Acc:P91857]	[more]
F11A5.4	1.933e-27	36.00	pep chromosome:WBcel235:V:16195679:16196290:1 gene...	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ran	5.138e-124	86.84	gene:FBgn0020255 transcript:FBtr0340164	[more]
Ran	5.138e-124	86.84	gene:FBgn0020255 transcript:FBtr0073471	[more]
Ran	5.138e-124	86.84	gene:FBgn0020255 transcript:FBtr0073472	[more]
Ran	5.138e-124	86.84	gene:FBgn0020255 transcript:FBtr0340165	[more]
Ran-like	5.169e-84	65.36	gene:FBgn0036497 transcript:FBtr0075616	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ran	1.274e-124	90.11	RAN, member RAS oncogene family [Source:NCBI gene;...	[more]
ran	1.274e-124	90.11	RAN, member RAS oncogene family [Source:NCBI gene;...	[more]
ran	1.274e-124	90.11	RAN, member RAS oncogene family [Source:NCBI gene;...	[more]
rab7a	9.089e-30	34.36	RAB7a, member RAS oncogene family [Source:ZFIN;Acc...	[more]
rab7a	9.089e-30	34.36	RAB7a, member RAS oncogene family [Source:ZFIN;Acc...	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ran	1.686e-124	88.30	RAN, member RAS oncogene family [Source:NCBI gene;...	[more]
rab7a	3.488e-30	34.97	RAB7A, member RAS oncogene family [Source:NCBI gen...	[more]
rab30	2.967e-28	33.94	RAB30, member RAS oncogene family [Source:NCBI gen...	[more]
rab5a	4.588e-27	32.74	RAB5A, member RAS oncogene family [Source:NCBI gen...	[more]
vasp	4.807e-27	31.74	vasodilator stimulated phosphoprotein [Source:Xenb...	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ran	1.735e-124	88.30	RAN, member RAS oncogene family [Source:MGI Symbol...	[more]
Ran	1.735e-124	88.30	RAN, member RAS oncogene family [Source:MGI Symbol...	[more]
1700009N14Rik	1.274e-120	86.17	RIKEN cDNA 1700009N14 gene [Source:MGI Symbol;Acc:...	[more]
Rasl2-9	1.105e-117	82.98	RAS-like, family 2, locus 9 [Source:MGI Symbol;Acc...	[more]
Rab7	9.705e-30	34.36	RAB7, member RAS oncogene family [Source:MGI Symbo...	[more]

BLAST of GTP-binding nuclear protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P38542\|RAN_BRUMA	1.221e-126	88.48	GTP-binding nuclear protein Ran OS=Brugia malayi O...	[more]
sp\|O17915\|RAN_CAEEL	2.273e-125	87.43	GTP-binding nuclear protein ran-1 OS=Caenorhabditi...	[more]
sp\|P52301\|RAN_XENLA	8.738e-124	88.30	GTP-binding nuclear protein Ran OS=Xenopus laevis ...	[more]
sp\|P42558\|RAN_CHICK	8.738e-124	88.30	GTP-binding nuclear protein Ran OS=Gallus gallus O...	[more]
sp\|P79735\|RAN_DANRE	9.620e-124	90.11	GTP-binding nuclear protein Ran OS=Danio rerio OX=...	[more]

BLAST of GTP-binding nuclear protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A267GL75	1.287e-125	90.91	GTP-binding nuclear protein (Fragment) OS=Macrosto...	[more]
A0A267G1T7	1.312e-125	90.91	GTP-binding nuclear protein (Fragment) OS=Macrosto...	[more]
A0A1I8HZD4	2.789e-125	90.91	GTP-binding nuclear protein OS=Macrostomum lignano...	[more]
A0A0N5CX98	1.442e-124	88.48	GTP-binding nuclear protein OS=Thelazia callipaeda...	[more]
A0A4Z2DXJ0	1.527e-124	90.37	GTP-binding nuclear protein OS=Schistosoma japonic...	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ran	2.409e-125	88.24	RAN, member RAS oncogene family [Source:NCBI gene;...	[more]
rab7a	7.703e-30	34.36	ras-related protein rab7 [Source:NCBI gene;Acc:103...	[more]
ENSAMXT00000041258.1	2.216e-29	33.13	RAB7A, member RAS oncogene family [Source:NCBI gen...	[more]
rab7b	4.906e-29	33.13	ras-related protein rab7-like [Source:NCBI gene;Ac...	[more]
ENSAMXT00000002303.2	6.674e-29	33.13	RAB7A, member RAS oncogene family [Source:NCBI gen...	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ran	1.784e-102	88.96	RAN, member RAS oncogene family [Source:NCBI gene;...	[more]
rab30	1.097e-31	37.16	RAB30, member RAS oncogene family [Source:ZFIN;Acc...	[more]
rab5c	1.821e-28	33.33	RAB5C, member RAS oncogene family [Source:ZFIN;Acc...	[more]
ENSPMAT00000000009.1	2.206e-27	33.33	pep scaffold:Pmarinus_7.0:GL476426:408368:444599:1...	[more]
rab5c	1.669e-26	32.99	RAB5C, member RAS oncogene family [Source:ZFIN;Acc...	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
GSP2	3.269e-117	85.25	GTP binding protein (mammalian Ranp homolog); invo...	[more]
GSP1	5.577e-117	85.25	Ran GTPase; GTP binding protein (mammalian Ranp ho...	[more]
YPT6	1.145e-24	31.35	Rab family GTPase; required for endosome-to-Golgii...	[more]
VPS21	3.569e-24	32.14	Endosomal Rab family GTPase; required for endocyti...	[more]
YPT53	6.598e-24	32.93	Stress-induced Rab family GTPase; required for vac...	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO37375	2.170e-125	90.81	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45332	4.536e-30	32.93	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43734	9.385e-30	34.62	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO44528	2.938e-28	34.34	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40980	4.249e-28	30.12	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of GTP-binding nuclear protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ran	5.743e-125	89.73	RAN, member RAS oncogene family [Source:NCBI gene;...	[more]
rab7a	6.786e-30	34.36	ras-related protein rab7 [Source:NCBI gene;Acc:101...	[more]
ENSORLT00000021125.2	7.338e-30	34.36	RAB7A, member RAS oncogene family [Source:NCBI gen...	[more]
rab10	2.060e-28	32.37	RAB10, member RAS oncogene family [Source:NCBI gen...	[more]
zgc:171927	9.495e-28	34.16	ras-related protein ORAB-1-like [Source:NCBI gene;...	[more]

BLAST of GTP-binding nuclear protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000072522.1	2.767e-143	100.00	SMESG000072522.1	[more]
SMESG000031968.1	1.779e-26	32.67	SMESG000031968.1	[more]
SMESG000051108.1	2.532e-26	34.36	SMESG000051108.1	[more]
SMESG000075649.1	2.551e-26	30.67	SMESG000075649.1	[more]
SMESG000049854.1	3.206e-26	31.68	SMESG000049854.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30030013 ID=SMED30030013|Name=GTP-binding nuclear protein|organism=Schmidtea mediterranea sexual|type=transcript|length=837bp
TAAAATTGAATTTGTTTGTCTTTGTTGTTTAATCACACATTTTAAATAAG
TCTGAACTGTTTTAAAAAGATGTCTGGTGATGCCGTAGCTCAGTTTAAAC
TGGTATTAGTTGGTGACGGTGGAACAGGCAAAACTACTTTTGTAAAGAGA
CATGTTACAGGAGAATTTGAAAAGAAATATGTCGCCACACTTGGAGTTGA
AGTTCATCCTTTGGAGTTCAATACGACTCGTGGAAAAATTCGTTTCAATG
TCTGGGATACTGCAGGCCAAGAAAAGTTTGGAGGTCTTAGAGATGGATAC
TATATTCAAGGCCAATGTGCTATCATTATGTTTGATGTAACTAGTCGTAT
TACATATAAAAATGTACCGAATTGGCATCGAGATTTAGTTAGGGTATGTG
AAAACATCCCTATTGTTCTCGTAGGTAATAAGGTGGATATTAAAGATAGA
AAGGTTAAGGCTAAGACAATTACCTTTCATAGAAAGAAGAATTTACAATA
TTACGATGTCTCTGCTAAGTCTAATTATAACTTTGAAAAACCATTTTTAT
GGATTGCTCGCAAATTGGTTGGAGATCCAAATCTCGAATTTGCTGAAATG
CCTGCCTTGGCACCTCCTGAAGTTCCAATGGATCCAAACTGGGTAGCTCA
ATGCGAAGCTGAAATCCAACAGGCTGCAGCTGCTCCATTGCCTGATGAGG
ATGAAGACTTGTGAAAATAAATTTTGTGTTGAATAATAATTGATTTATAG
TTCGTTATTTTTATGACTTATTGCAAGTAATTATTTTTCCGACATTTTTT
TATTTATTAAATACTGTTGTTTAAATAATCTATTTTG

protein sequence of SMED30030013-orf-1

>SMED30030013-orf-1 ID=SMED30030013-orf-1|Name=SMED30030013-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=215bp
MSGDAVAQFKLVLVGDGGTGKTTFVKRHVTGEFEKKYVATLGVEVHPLEF
NTTRGKIRFNVWDTAGQEKFGGLRDGYYIQGQCAIIMFDVTSRITYKNVP
NWHRDLVRVCENIPIVLVGNKVDIKDRKVKAKTITFHRKKNLQYYDVSAK
SNYNFEKPFLWIARKLVGDPNLEFAEMPALAPPEVPMDPNWVAQCEAEIQ
QAAAAPLPDEDEDL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut
PLANA:0000039	gamma neoblast
PLANA:0000429	neoblast
PLANA:0002032	epidermal cell
PLANA:0002109	X1 cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR005225	Small_GTP-bd_dom
IPR002041	Ran_GTPase
IPR027417	P-loop_NTPase
IPR001806	Small_GTPase

Vocabulary: **biological process**
Term	Definition
GO:0006913	nucleocytoplasmic transport
GO:0007264	small GTPase mediated signal transduction
GO:0006886	intracellular protein transport
GO:0007165	signal transduction
GO:0006810	transport
GO:0015031	protein transport

Vocabulary: **molecular function**
Term	Definition
GO:0005525	GTP binding
GO:0003924	GTPase activity
GO:0000166	nucleotide binding

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR002041	Ran GTPase	PRINTS	PR00627	GTPRANTC4	coord: 163..185 score: 74.08 coord: 22..36 score: 89.23 coord: 125..143 score: 81.78 coord: 69..87 score: 89.88 coord: 89..110 score: 85.49
IPR002041	Ran GTPase	PANTHER	PTHR24071	FAMILY NOT NAMED	coord: 5..214
IPR002041	Ran GTPase	PROSITE	PS51418	RAN	coord: 2..166 score: 30.425
None	No IPR available	SMART	SM00175	rab_sub_5	coord: 9..169 e-value: 1.7E-31 score: 120.6
None	No IPR available	SMART	SM00173	ras_sub_4	coord: 6..169 e-value: 2.1E-12 score: 56.9
None	No IPR available	SMART	SM00176	ran_sub_2	coord: 14..214 e-value: 8.4E-157 score: 536.9
None	No IPR available	SMART	SM00174	rho_sub_3	coord: 11..169 e-value: 3.8E-9 score: -1.6
None	No IPR available	GENE3D	G3DSA:3.40.50.300		coord: 3..214 e-value: 1.9E-66 score: 225.2
None	No IPR available	PANTHER	PTHR24071:SF17	GTP-BINDING NUCLEAR PROTEIN RAN	coord: 5..214
None	No IPR available	CDD	cd00877	Ran	coord: 9..174 e-value: 4.99718E-132 score: 365.856
IPR005225	Small GTP-binding protein domain	TIGRFAM	TIGR00231	TIGR00231	coord: 8..157 e-value: 1.9E-25 score: 87.5
IPR001806	Small GTPase	PFAM	PF00071	Ras	coord: 10..166 e-value: 6.2E-51 score: 172.2
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	coord: 8..192