L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

Overview
NameL-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Smed IDSMED30030002
Length (bp)1074
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (SMED30030002) t-SNE clustered cells

Violin plots show distribution of expression levels for L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (SMED30030002) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (SMED30030002) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (SMED30030002) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30030002

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
posterior sideSMED30030002h1SMcG0001198 dd_Smed_v4_4391_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30030002h1SMcG0001198 dd_Smed_v4_4391_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Human
Match: AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:HGNC Symbol;Acc:HGNC:14235])

HSP 1 Score: 171.4 bits (433), Expect = 3.366e-50
Identity = 80/189 (42.33%), Postives = 128/189 (67.72%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS 655
            +R+AF+  +W P++ EWL A+  IQ EE+ RI  + + RDAKA++AGRL+ RK++ + LN+  N +RL+RT KG+P L A D        +FN+SHQGD+ VL A   ++ G+D+MK   P    S+ +FF +MKR+F  KEW +I   + +  ++ +FYR+W LKES++KA+G+G+G +L+++   +S
Sbjct:   17 VRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVL-AKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFP-GRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLS 203
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Human
Match: AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:HGNC Symbol;Acc:HGNC:14235])

HSP 1 Score: 119.013 bits (297), Expect = 7.896e-32
Identity = 56/140 (40.00%), Postives = 92/140 (65.71%), Query Frame = 2 
Query:  236 LARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS 655
            + RK++ + LN+  N +RL+RT KG+P L A D        +FN+SHQGD+ VL A   ++ G+D+MK   P    S+ +FF +MKR+F  KEW +I   + +  ++ +FYR+W LKES++KA+G+G+G +L+++   +S
Sbjct:    1 MIRKLVAEKLNIPWNHIRLQRTAKGKPVL-AKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFP-GRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLS 138
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Human
Match: AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:HGNC Symbol;Acc:HGNC:14235])

HSP 1 Score: 118.627 bits (296), Expect = 2.145e-31
Identity = 56/140 (40.00%), Postives = 92/140 (65.71%), Query Frame = 2 
Query:  236 LARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS 655
            + RK++ + LN+  N +RL+RT KG+P L A D        +FN+SHQGD+ VL A   ++ G+D+MK   P    S+ +FF +MKR+F  KEW +I   + +  ++ +FYR+W LKES++KA+G+G+G +L+++   +S
Sbjct:    1 MIRKLVAEKLNIPWNHIRLQRTAKGKPVL-AKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFP-GRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLS 138
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Human
Match: AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:HGNC Symbol;Acc:HGNC:14235])

HSP 1 Score: 115.161 bits (287), Expect = 1.210e-30
Identity = 54/121 (44.63%), Postives = 81/121 (66.94%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLP 451
            +R+AF+  +W P++ EWL A+  IQ EE+ RI  + + RDAKA++AGRL+ RK++ + LN+  N +RL+RT KG+P L A D        +FN+SHQGD+ VL A   ++ G+D+MK   P
Sbjct:   17 VRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVL-AKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFP 136
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Celegans
Match: T04G9.4 (pep chromosome:WBcel235:X:772353:775371:1 gene:WBGene00020215.1 transcript:T04G9.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T04G9.4)

HSP 1 Score: 110.153 bits (274), Expect = 1.274e-27
Identity = 66/214 (30.84%), Postives = 104/214 (48.60%), Query Frame = 2 
Query:  137 WLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQI--ICSISNNSEPWV----SWIDQEKSL---WKFEEHVLDSDHVVGI 751
            + KA+  I  EE  RI  + ++ DA A L GRLL R           N +R ERTE+G+PFL              N+SHQGD+    +    K GVDVM++    +  + D++   M +  + +E   +     +  KM +FYR+WCLKE+ +KA G+GI  DL  +    ++ +   P      + + ++  L   W FEE  +D+ H   +
Sbjct:   29 FRKAVQSITEEEFQRIPEFRHREDALACLFGRLLLRHSAQKFSGEPWNTIRFERTERGKPFLAV----PADTTFGLNVSHQGDYVAFASSCSSKVGVDVMRLDNERNNKTADEYINSMAKSASPEELRMMRSQPTEAMKMTMFYRYWCLKEAILKATGVGIMKDLNSLDFRVNLQDRYRPGAFVTSTTVLEDGRLQDQWIFEETFVDAKHSAAV 238
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Celegans
Match: T28H10.1 (pep chromosome:WBcel235:V:12503801:12505146:1 gene:WBGene00012142.1 transcript:T28H10.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:T28H10.1)

HSP 1 Score: 91.6633 bits (226), Expect = 6.491e-21
Identity = 65/216 (30.09%), Postives = 104/216 (48.15%), Query Frame = 2 
Query:  143 KAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEK-DIDKMRLFYRHWCLKESYVKALGIGIGIDLE----QIICSISNNS-------EPWVSWIDQEKSLWKFEEHVLDSDHVVGIA 754
            +A+ C    +  +   + Y+ DA A L GRL+ RK  T  ++   + +   R E G+P L+ +         ++N+SH GD  VL  G   + GVDVM+V     E + +     +KR F+E E   +   +K ++ +   FYR WCLKES +KA G+G+   L     Q+  S  + S       + +   I Q +  W FEE  +  +H V +A
Sbjct:   24 RAILCASESDVEQQRRFRYKEDALACLIGRLIPRKAATISISRQWSDLEFSRNENGKPSLIQNKSDYSRQNFEYNVSHHGDLVVLATG-DTRIGVDVMRVNEARRETASEQ-MNTLKRHFSENEIEMVKGGDKCELKRWHAFYRIWCLKESILKATGVGLPDGLHNHTFQVDSSYDHASGHSTVSTQYYHRLIPQPQ--WIFEESFIGENHCVAVA 235
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Fly
Match: CG32099 (gene:FBgn0052099 transcript:FBtr0076000)

HSP 1 Score: 155.992 bits (393), Expect = 1.019e-44
Identity = 109/299 (36.45%), Postives = 159/299 (53.18%), Query Frame = 2 
Query:   83 IFLRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVA---HDLPQLANCLDFNLSHQGDFTVLTAGLGVKT-------GVDVMKVQL----PVSENSVDDFFGLMKRQFAEKEWISINDPEKD-IDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSI--SNNSEPWVSWI--------DQEKSLWKFEEHVLDSDHVVGIAWHGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQPLPPY 904
            I  R+AF+  SW P  P+  +A++ IQ EER R+  + +  D  +SL GRL  RK ++    L +  V+  R  +G+P+ V    +D P L+    FN+SHQG   VL AG+  ++       G DVMK++     P+SE     FFGLMK +F+ +EW  I  P  D  ++++ F RHWCLKE+YVK LG+GI +DL++I  S+  + + E  VS +        DQ    W FEEH+L  D+   IA+     Q+    G F  L   E+L   E    +E E  I++  K  L PY
Sbjct:    5 ICTRWAFDLGSWRPTLPQLSQAVASIQPEERARLMKFHFIDDFLSSLIGRLFMRKYVSTCSGLPSAEVKFARDVRGKPYWVKGEDYDGPPLS----FNVSHQGSL-VLLAGIAGESSDPDFGIGTDVMKIEYNGGKPLSE-----FFGLMKSKFSAEEWSYIGRPHHDEREQVKAFMRHWCLKEAYVKELGVGITVDLQKISFSVDTTRSLETDVSPLIGTSLRCHDQPMDNWHFEEHLLQEDYCAAIAFRNCLPQER---GKFKFLQVEELLVKSED---SELEEVISYCQKALLKPY 287
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Zebrafish
Match: aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:ZFIN;Acc:ZDB-GENE-050913-36])

HSP 1 Score: 190.66 bits (483), Expect = 5.247e-58
Identity = 111/289 (38.41%), Postives = 168/289 (58.13%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQL--ANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNNS--EPWVSW-----IDQ-EKSLWKFEEHVLDSDHVVGIAWHGQNVQQDVKFGN---------FVHLTFAEILASMETLHRAESEFWINFKSKQPLP 898
            +R+AF   SW P++ +W  A  C+Q EE+ RI  + + +DAK+++AGRLL RK++ + +  + +  RLERTE+G+P+     LPQ   A    FN+SHQGD+ VL A  G + G+DVMK   P S +SV +FF +M RQF + EW +I     D D++ +FYRHW LKES++KA+G G+G DL++    IS N   E  V W     +D+ E+  W FEE +LD DH V +A    ++    K G          F  L+F+++++    L   +  +W  F+ K+  P
Sbjct:    4 VRWAFRCGSWVPSRSDWTLAARCVQQEEKQRIGQFVFAKDAKSAMAGRLLIRKLVCEKMGFAWDGFRLERTERGKPY-----LPQTSSAPSWSFNVSHQGDYAVLAAEAGRQVGIDVMKTSRPGS-SSVQEFFRIMNRQFTDLEWTNIRTAGSDWDQLHMFYRHWALKESFIKAIGTGLGFDLQRAEFHISPNQMREGQVYWQTRMYLDREEEEDWTFEESLLDKDHHVAVALGKPDISMSKKDGGSSCEAPPAAFTALSFSDLVSQATPLLDEDPAYWEEFQKKKDAP 286
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Xenopus
Match: rin3 (Ras and Rab interactor 3 [Source:Xenbase;Acc:XB-GENE-488895])

HSP 1 Score: 218.394 bits (555), Expect = 2.763e-68
Identity = 117/284 (41.20%), Postives = 169/284 (59.51%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS-------NNSEPWVSWIDQEKSLWKFEEHVLDSDHVVGIA-------WHGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQPLP 898
            +R+AF+ SSW P++ EWL    C+Q EE+ RI  + + RDAKA++AGRLL RKVI + L +  + + L+RTEKG+PFL      +      FN+SHQGD+ VL A    + GVD+MK  LP S  S+ +FF LM RQF EKEW SI     D  ++ +FYRHW LKES++KA+G+G+G +L+ I   +S          +    ++D E+  W FEE +LD+ H V +A        H  +   DV    F  L+F +++AS   +   + ++WINF+SKQ  P
Sbjct:   14 VRWAFHCSSWAPSQAEWLLCARCVQPEEKERIGQFMFTRDAKAAMAGRLLMRKVIAEKLQIPWDKILLQRTEKGKPFLCYGSSSEYP-LFKFNVSHQGDYAVLAAEPYRQVGVDIMKTDLPGS-GSIKEFFRLMDRQFTEKEWHSIRSMNSDWAQLDMFYRHWALKESFIKAIGVGLGFNLQLIEFEVSPVNMDIGKTYKQTKMFLDDEEETWAFEEILLDNQHHVAVALGEVDQLLHQSHKINDVTESTFELLSFEDLMASAVPMSDEDPDYWINFQSKQEFP 295
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Mouse
Match: Aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:MGI Symbol;Acc:MGI:1914868])

HSP 1 Score: 178.333 bits (451), Expect = 5.325e-53
Identity = 82/189 (43.39%), Postives = 128/189 (67.72%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS 655
            +R+AF+  +W P++ EWL AM  IQ EE+ RI  + + RDAKA+LAGRL+ RK++ + LN+  + +RL+RT KG+P L    L    N  +FN+SHQGD+ VL A   V+ G+D+MK   P    S+ +FF +MKR+F +KEW +I     +  ++ +FYRHW LKES++KA+G+G+G +++++   +S
Sbjct:   17 VRWAFSCGTWLPSRAEWLLAMRSIQPEEKERIGKFVFARDAKAALAGRLMIRKLVAEKLNIPWDHIRLQRTSKGKPVLAKDSLNPYPN-FNFNISHQGDYAVLAAEPEVQVGIDIMKTSFP-GRGSIPEFFHIMKRKFTKKEWETIRSFNDEWTQLDMFYRHWALKESFIKAIGVGLGFEMQRLEFDVS 203
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. UniProt/SwissProt
Match: sp|Q6DJH2|ADPPT_XENLA (L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Xenopus laevis OX=8355 GN=aasdhppt PE=2 SV=1)

HSP 1 Score: 223.402 bits (568), Expect = 1.041e-69
Identity = 119/284 (41.90%), Postives = 170/284 (59.86%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNNS-------EPWVSWIDQEKSLWKFEEHVLDSDHVVGIAW-------HGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQPLP 898
            +R+AF   SW P++ EWL    C+Q EE+ RI  + + RDAKA++AGRLL RKVI D L +  + + LERT KG+PFL      +   C +FN+SHQGD+ VL A    + GVD+MK  LP S +S+++FF LM RQF EKEW SI     D  ++ +FYRHW LKES++KA+G+G+G +L++I   +S  +       +    ++D E+  W FEE +LD+ H V IA        H      DV    F  L F +++ S   +   + ++WINF+SKQ LP
Sbjct:   14 VRWAFQCGSWCPSQAEWLLCARCVQPEEKQRIGHFMFTRDAKAAMAGRLLMRKVIADKLQIPWDRILLERTGKGKPFLTGGSSSEYP-CFNFNVSHQGDYAVLAAEPDRQVGVDIMKTDLPGS-SSIEEFFRLMNRQFTEKEWNSIRSMNNDWARLDMFYRHWALKESFIKAIGVGLGFNLQRIEFEVSPVTMEIGKIYKETKMFLDDEEETWTFEEILLDNQHHVAIALGEVDHLQHQSPKIGDVAESTFTLLNFEDLMVSAIPMSDEDPDYWINFQSKQELP 295
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. UniProt/SwissProt
Match: sp|Q9CQF6|ADPPT_MOUSE (L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Mus musculus OX=10090 GN=Aasdhppt PE=1 SV=1)

HSP 1 Score: 178.333 bits (451), Expect = 3.725e-52
Identity = 82/189 (43.39%), Postives = 128/189 (67.72%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS 655
            +R+AF+  +W P++ EWL AM  IQ EE+ RI  + + RDAKA+LAGRL+ RK++ + LN+  + +RL+RT KG+P L    L    N  +FN+SHQGD+ VL A   V+ G+D+MK   P    S+ +FF +MKR+F +KEW +I     +  ++ +FYRHW LKES++KA+G+G+G +++++   +S
Sbjct:   17 VRWAFSCGTWLPSRAEWLLAMRSIQPEEKERIGKFVFARDAKAALAGRLMIRKLVAEKLNIPWDHIRLQRTSKGKPVLAKDSLNPYPN-FNFNISHQGDYAVLAAEPEVQVGIDIMKTSFP-GRGSIPEFFHIMKRKFTKKEWETIRSFNDEWTQLDMFYRHWALKESFIKAIGVGLGFEMQRLEFDVS 203
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. UniProt/SwissProt
Match: sp|B2RYJ4|ADPPT_RAT (L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Rattus norvegicus OX=10116 GN=Aasdhppt PE=2 SV=1)

HSP 1 Score: 176.407 bits (446), Expect = 2.118e-51
Identity = 106/282 (37.59%), Postives = 162/282 (57.45%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNNSEPWVSWIDQEKSL---------WKFEEHVLDSDHVVGIAWHG------QNV--QQDVKFG--NFVHLTFAEILASMETLHRAESEFWINF 877
            +R+AF+  +W P+  EWL A+  IQ EE+ RI  + + RDAKA+LAGRL+ RK++ + LN+  + +RL+RT KG+P L    L    N  +FN+SHQGD+TVL A   ++ G+D+MK   P    S+ +FF +MKR+F  KEW +I     +  ++ +FYRHW LKES++KA+G+G+G +++++   +S  S   +  + +E  L         W FEE  +D  H V +A         QNV  Q D K     F  L F +++AS   +   +  FW  F
Sbjct:   17 VRWAFSCGTWLPSPAEWLLAVRSIQPEEKERIGQFVFARDAKAALAGRLMIRKLVAEKLNIPWDHIRLQRTSKGKPILAKDTLNPYPN-FNFNISHQGDYTVLAAEPELQVGIDIMKTSFP-GRGSIPEFFHIMKRKFTNKEWETIRSFNDEWSQLDMFYRHWALKESFIKAIGVGLGFEMQRLEFDVSPLSMD-IGQVYKETRLILDGEEEKEWAFEESKIDQHHFVAVALRKPDGSRHQNVSYQDDSKPSQRQFTILNFNDLIASAIPMTPEDPSFWDCF 295
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. UniProt/SwissProt
Match: sp|Q9NRN7|ADPPT_HUMAN (L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Homo sapiens OX=9606 GN=AASDHPPT PE=1 SV=2)

HSP 1 Score: 171.4 bits (433), Expect = 1.616e-49
Identity = 80/189 (42.33%), Postives = 128/189 (67.72%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS 655
            +R+AF+  +W P++ EWL A+  IQ EE+ RI  + + RDAKA++AGRL+ RK++ + LN+  N +RL+RT KG+P L A D        +FN+SHQGD+ VL A   ++ G+D+MK   P    S+ +FF +MKR+F  KEW +I   + +  ++ +FYR+W LKES++KA+G+G+G +L+++   +S
Sbjct:   17 VRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVL-AKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFP-GRGSIPEFFHIMKRKFTNKEWETIRSFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLS 203
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. UniProt/SwissProt
Match: sp|Q5NVE1|ADPPT_PONAB (L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase OS=Pongo abelii OX=9601 GN=AASDHPPT PE=2 SV=1)

HSP 1 Score: 171.4 bits (433), Expect = 1.779e-49
Identity = 80/189 (42.33%), Postives = 128/189 (67.72%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS 655
            +R+AF+  +W P++ EWL A+  IQ EE+ RI  + + RDAKA++AGRL+ RK++ + LN+  N +RL+RT KG+P L A D        +FN+SHQGD+ VL A   ++ G+D+MK   P    S+ +FF +MKR+F  KEW +I   + +  ++ +FYR+W LKES++KA+G+G+G +L+++   +S
Sbjct:   17 VRWAFSCGTWLPSRAEWLLAVRSIQPEEKERIGQFVFARDAKAAMAGRLMIRKLVAEKLNIPWNHIRLQRTAKGKPVL-AKDSSNPYPNFNFNISHQGDYAVLAAEPELQVGIDIMKTSFP-GRGSIPEFFHIMKRKFTNKEWETIRGFKDEWTQLDMFYRNWALKESFIKAIGVGLGFELQRLEFDLS 203
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. TrEMBL
Match: A0A1L8HB19 (ACPS domain-containing protein OS=Xenopus laevis OX=8355 GN=XELAEV_18016276mg PE=4 SV=1)

HSP 1 Score: 223.016 bits (567), Expect = 5.583e-67
Identity = 118/284 (41.55%), Postives = 170/284 (59.86%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNNS-------EPWVSWIDQEKSLWKFEEHVLDSDHVVGIAW-------HGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQPLP 898
            +R+AF   SW P++ EWL    C+Q EE+ RI  + + RDAKA++AGRLL RKVI D L +  + + LERT KG+PFL      +   C +FN+SHQGD+ VL A    + GVD+MK  LP S +S+++FF LM RQF EKEW SI     D  ++ +FYRHW LKES++KA+G+G+G +L++I   +S  +       +    ++D E+  W FEE +LD+ H V +A        H      DV    F  L F +++ S   +   + ++WINF+SKQ LP
Sbjct:   14 VRWAFQCGSWCPSQAEWLLCARCVQPEEKQRIGHFMFTRDAKAAMAGRLLMRKVIADKLQIPWDRILLERTGKGKPFLTGGSSSEYP-CFNFNVSHQGDYAVLAAEPDRQVGVDIMKTDLPGS-SSIEEFFRLMNRQFTEKEWNSIRSMNNDWARLDMFYRHWALKESFIKAIGVGLGFNLQRIEFEVSPVTMEIGKIYKETKMFLDDEEETWTFEEILLDNQHHVAVALGELDHLQHQSPKIGDVAENTFTLLNFEDLMVSAIPMSDEDPDYWINFQSKQELP 295
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. TrEMBL
Match: B1WB10 (LOC100145738 protein OS=Xenopus tropicalis OX=8364 GN=aasdhppt PE=2 SV=1)

HSP 1 Score: 218.394 bits (555), Expect = 4.338e-65
Identity = 117/284 (41.20%), Postives = 169/284 (59.51%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS-------NNSEPWVSWIDQEKSLWKFEEHVLDSDHVVGIA-------WHGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQPLP 898
            +R+AF+ SSW P++ EWL    C+Q EE+ RI  + + RDAKA++AGRLL RKVI + L +  + + L+RTEKG+PFL      +      FN+SHQGD+ VL A    + GVD+MK  LP S  S+ +FF LM RQF EKEW SI     D  ++ +FYRHW LKES++KA+G+G+G +L+ I   +S          +    ++D E+  W FEE +LD+ H V +A        H  +   DV    F  L+F +++AS   +   + ++WINF+SKQ  P
Sbjct:   14 VRWAFHCSSWAPSQAEWLLCARCVQPEEKERIGQFMFTRDAKAAMAGRLLMRKVIAEKLQIPWDKILLQRTEKGKPFLCYGSSSEYP-LFKFNVSHQGDYAVLAAEPYRQVGVDIMKTDLPGS-GSIKEFFRLMDRQFTEKEWHSIRSMNSDWAQLDMFYRHWALKESFIKAIGVGLGFNLQLIEFEVSPVNMDIGKTYKQTKMFLDDEEETWAFEEILLDNQHHVAVALGEVDQLLHQSHKINDVTESTFELLSFEDLMASAVPMSDEDPDYWINFQSKQEFP 295
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. TrEMBL
Match: A0A3M6UTV8 (ACPS domain-containing protein OS=Pocillopora damicornis OX=46731 GN=pdam_00008235 PE=4 SV=1)

HSP 1 Score: 206.838 bits (525), Expect = 7.412e-61
Identity = 115/278 (41.37%), Postives = 161/278 (57.91%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS-------NNSEPWVSWIDQ-EKSLWKFEEHVLDSDHVVGIAW---HGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQ 889
            +R AF S +W P + EWL   SC+QTEE+ RI ++ +++DAK++L GRLL RKVI+D   +  N V L+RTEKG+PFL    +       +FN+SHQGDFTVL A    + GVDVMK   P S ++V  FF  M++QF   EW +I     + +++++FYRHWCLKESYVKA G GIG DL+ +   I+       N +     ++D+ E   W FEE  LD  H V +A    H    +    F  F  L F +I++S   L       WI F++K+
Sbjct:    9 VRLAFRSGAWKPTRKEWLLGTSCLQTEEKERIMNFVFKKDAKSALIGRLLMRKVISDFTKIPYNEVILKRTEKGKPFLANDPMEPSQRKFNFNISHQGDFTVLAAEPESQVGVDVMKTTYP-SSSTVPGFFHTMRKQFTGYEWQTIKSQPSEWNQLQMFYRHWCLKESYVKATGTGIGRDLQSVEFQINTKELSPQNVTSDTNFFLDEDEMDGWLFEETKLDDLHQVAVALGPSHTTYKETRSGFSTFKILQFDDIVSSAIPLFPEVESDWIEFQAKK 285
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. TrEMBL
Match: W4X9S4 (ACPS domain-containing protein OS=Strongylocentrotus purpuratus OX=7668 PE=4 SV=1)

HSP 1 Score: 206.068 bits (523), Expect = 1.256e-60
Identity = 112/282 (39.72%), Postives = 164/282 (58.16%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANC--LDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQI----------ICSISNNSEPWVSWIDQEKSLWKFEEHVLDSDHVVGIAWHGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQPLP 898
            LR+AF  SSW P++ +WL A S IQ EE++RI  + + +DAK+S+AGRLLARK I + LN+S   + L RT++G+P+L   D          +FN SH GDF VL     +  GVDVMKV  P     ++DFF  MK+QF   EW +I   E    ++  FYR+WCLKESY+KALGIG+G DL++             S++ ++E ++   D++   W F+E +LD DH V +A      +      +F  LT  ++L+S   +H  + ++W +F SKQ  P
Sbjct:    4 LRWAFKCSSWQPDQSQWLLASSSIQPEEKHRIGQFVFTKDAKSSMAGRLLARKAIHECLNISWADINLVRTDRGKPYLKNTDDIDKTTYPNFNFNASHHGDFAVLATEPALTCGVDVMKVVRP--NQKIEDFFRNMKKQFTPHEWNTIMSAETQYQQLHRFYRYWCLKESYIKALGIGLGFDLQRAEFRLNTLELSTSSVATDTELYLR--DRQDKNWVFQEMLLDDDHYVAVAVQLGPDRSTPCCPSFTILTPEQLLSSAHPMHPEDMDYWTSFASKQEAP 281
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. TrEMBL
Match: A0A401NKN8 (ACPS domain-containing protein OS=Scyliorhinus torazame OX=75743 GN=scyTo_0009340 PE=4 SV=1)

HSP 1 Score: 206.068 bits (523), Expect = 1.868e-60
Identity = 113/287 (39.37%), Postives = 172/287 (59.93%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSIS-------NNSEPWVSWID-QEKSLWKFEEHVLDSDHVVGIAWHG------------QNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQ 889
            LR+AF  SSW P++ EWL A  C+Q EER RI  + + RDAKA++ GRLL RK+I + L +  N ++L+RT KG+PFL    L  + N  +FN+SHQGD+TVL A   ++ G+DVMK   P S +SV +FF +M RQF + EW +I     +  ++ +FYRHW LKES++KA+G+G+G +L++I   +S         S+  + ++D  ++  W FEE +LD +H V +A               +NV Q+     F  LTF ++++S   +      +W NF++KQ
Sbjct:   16 LRWAFGFSSWRPSRCEWLMAARCVQAEERERIGEFVFARDAKAAMGGRLLVRKLIAEKLRIPWNEIQLQRTTKGKPFLANPVLNTIPN-FNFNISHQGDYTVLAAEPNLQVGIDVMKTDFPGS-SSVTEFFRIMNRQFTDHEWNTIKMAGDEWAQLVMFYRHWALKESFLKAIGVGVGFNLQRIEFHVSPLHMRVGQVSKETIMFLDGDQEEGWTFEETMLDENHHVAVALGKPDMITKTPLQLQENVNQEP--SQFTLLTFKDLISSAIAMAPDNPMYWENFQAKQ 298
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Cavefish
Match: aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:ZFIN;Acc:ZDB-GENE-050913-36])

HSP 1 Score: 197.593 bits (501), Expect = 9.124e-61
Identity = 105/285 (36.84%), Postives = 170/285 (59.65%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNN--------SEPWVSWIDQEKSLWKFEEHVLDSDHVVGIAWHGQ-----NVQQDVKFG--NFVHLTFAEILASMETLHRAESEFWINFKSKQPLP 898
            +R+AF   +W+P++ EWL A  CIQ EE+ RI  + + +DAK+++AGRLL R+++ + + L  +  RL RTE+G+P+L     P   +  +FN+SHQG++ VL A  G + G+D+MK   P S ++V +FF +M RQF E EW +I     D D++ +FYRHW LKES++KA+G G+G DL+++   IS N        S+  +   ++++  W FEE +LD  H V +A          V  D +    +F  L+++E+++    L   +  +W +F+SKQ  P
Sbjct:    4 VRWAFRCGAWSPSRSEWLLAARCIQQEEKNRIGQFIFTKDAKSAMAGRLLMRRLVCEKVCLPWDGFRLGRTERGKPYLAEPSSPGSLH-WNFNVSHQGNYAVLAAEPGRQVGIDIMKTTRPGS-STVQEFFRIMTRQFTELEWRTIRSAGSDWDQLAMFYRHWALKESFIKAIGSGLGFDLQRVEFHISPNQLQEGRVYSQTRMHLDEEQEDGWTFEECLLDKHHHVAVALGTPEGSVYKVSSDAEATPPSFTLLSYSELVSRATPLSDEDPAYWESFQSKQEAP 286
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Sea Lamprey
Match: aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:ZFIN;Acc:ZDB-GENE-050913-36])

HSP 1 Score: 201.83 bits (512), Expect = 9.189e-63
Identity = 114/300 (38.00%), Postives = 167/300 (55.67%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQL-------------ANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQI----------ICSISNNSEPWVSWIDQEKSLWKFEEHVLDSDHVVGIAWHGQN-VQQDVKFGN-------------FVHLTFAEILASMETLHRAESEFWINF 877
            +R+AF +++W P + +WL A  CIQ EER R++ + +  DAKA++AGRLL RK I ++L L    V L RT +G+P L+  D   +                L FN+SHQGDFTVL A LG   GVD+MK QL     + ++FF LM RQF   EW +I     D +K+ LFYRHWCLKESYVK +G+G+G++L++I          + +++ ++  +V     E + W F+E +LD  H V +A    + V Q+ +                FV LTF +++++   L   E EFW NF
Sbjct:   17 VRWAFRTANWQPTRSDWLLATRCIQAEERQRVSEFVFVEDAKAAMAGRLLLRKAIVEVLGLPWERVHLGRTAQGKPVLLTSDPHPVFDSENVTERGLDSVESLGFNVSHQGDFTVLAAELGHTIGVDIMKHQLR-GRQTTEEFFRLMSRQFTPLEWRTIRSGGSDWEKLGLFYRHWCLKESYVKGVGVGLGLNLQRIEFRLGSPRVDMSAVTQDTRLFVD--GAEDTGWLFQETMLDESHFVAVAVDRHSAVCQETQTSKGHRRSDESPCVRPFVSLTFQDLMSTAAPLSLEEPEFWENF 313
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Nematostella
Match: EDO47052 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNF6])

HSP 1 Score: 190.66 bits (483), Expect = 2.797e-58
Identity = 102/244 (41.80%), Postives = 140/244 (57.38%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDL--------------EQIIC--------SISNNSEPWVSWIDQEKSLWKFEEHVLDSDHVVGIA 754
            +R+AF S +W P K EWL A+S +Q EE+ R+  + +++DAK+SL GRLL RK I  +L +  + ++L RTEKG+PFLV            FN+SHQGDFTVL A    + GVDVMK   P     V  FF LM++QF  +EW ++N    +  ++++FYRHWCLKESYVKA+G+GIG DL              E+I C        SIS++              W F+E  LD +H V +A
Sbjct:    4 IRWAFRSEAWRPTKQEWLLALSLVQKEEKERVMRFVFKKDAKSSLIGRLLLRKAIAQMLAVPYHDLQLARTEKGKPFLVNKITDDGLKNFSFNVSHQGDFTVLAAEPCCQVGVDVMKTTYP-GGTDVQGFFHLMRKQFTPREWRTVNSQPTEWTQLQMFYRHWCLKESYVKAIGVGIGHDLQAVEFNLPTRLLSTEEITCDSQLYLKGSISHD--------------WSFQETKLDEEHQVAVA 232
[Close]
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Medaka
Match: aasdhppt (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [Source:NCBI gene;Acc:101169719])

HSP 1 Score: 200.29 bits (508), Expect = 1.033e-61
Identity = 106/285 (37.19%), Postives = 165/285 (57.89%), Query Frame = 2 
Query:   89 LRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDL---PQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNNSEPWVSWIDQEKSL--------WKFEEHVLDSDHVVGIAWHGQNVQQDVKFG----NFVHLTFAEILASMETLHRAESEFWINFKSKQPLP 898
            +R+AF   SW+P++ EWL A  C+Q EE+ RI  + Y +DAK+++ GRLL R+ + + + +    +RLER+ +G+P+L A+ L   P       FN+SHQGD+ VL A  GV+ GVD+MK  +P S +SV +FF +M RQF   EW  I     + +++  FYRHW LKES++KA+G G+G +L+++   +S       S + Q K L        W FEE +LD+DH V +A    +  +  +       F  L+F+E++AS   L   +  +W +F+ K   P
Sbjct:    4 VRWAFRCRSWSPSRTEWLFAARCVQPEEKDRIGQFVYTKDAKSAMVGRLLLRRFVCERMGIPWTEIRLERSPRGKPYL-ANPLKISPHFDRSWSFNISHQGDYVVLAADRGVQVGVDLMKTSMPGS-SSVPEFFRIMTRQFTAHEWSIIQSAGSEREQLATFYRHWTLKESFIKAIGTGLGFNLQRVEFHLSPEPLKPGSVLRQTKMLLDEEHEEAWIFEESMLDADHHVAVAMGLTDEARSARLAPPPSPFTLLSFSELIASASPLTEEDPAYWESFRMKVEAP 286
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Planmine SMEST
Match: SMESG000018744.1 (SMESG000018744.1)

HSP 1 Score: 583.178 bits (1502), Expect = 0.000e+0
Identity = 278/279 (99.64%), Postives = 279/279 (100.00%), Query Frame = 2 
Query:   74 MTKIFLRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNNSEPWVSWIDQEKSLWKFEEHVLDSDHVVGIAWHGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQPLPPYLM 910
            MTKIFLRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNNSEPWVSWIDQ+KSLWKFEEHVLDSDHVVGIAWHGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQPLPPYLM
Sbjct:    1 MTKIFLRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASLAGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLSHQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWISINDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNNSEPWVSWIDQDKSLWKFEEHVLDSDHVVGIAWHGQNVQQDVKFGNFVHLTFAEILASMETLHRAESEFWINFKSKQPLPPYLM 279
The following BLAST results are available for this feature:
BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4
Match NameE-valueIdentityDescription
AASDHPPT3.366e-5042.33aminoadipate-semialdehyde dehydrogenase-phosphopan... [more]
AASDHPPT7.896e-3240.00aminoadipate-semialdehyde dehydrogenase-phosphopan... [more]
AASDHPPT2.145e-3140.00aminoadipate-semialdehyde dehydrogenase-phosphopan... [more]
AASDHPPT1.210e-3044.63aminoadipate-semialdehyde dehydrogenase-phosphopan... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
T04G9.41.274e-2730.84pep chromosome:WBcel235:X:772353:775371:1 gene:WBG... [more]
T28H10.16.491e-2130.09pep chromosome:WBcel235:V:12503801:12505146:1 gene... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CG320991.019e-4436.45gene:FBgn0052099 transcript:FBtr0076000[more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
aasdhppt5.247e-5838.41aminoadipate-semialdehyde dehydrogenase-phosphopan... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
rin32.763e-6841.20Ras and Rab interactor 3 [Source:Xenbase;Acc:XB-GE... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Aasdhppt5.325e-5343.39aminoadipate-semialdehyde dehydrogenase-phosphopan... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6DJH2|ADPPT_XENLA1.041e-6941.90L-aminoadipate-semialdehyde dehydrogenase-phosphop... [more]
sp|Q9CQF6|ADPPT_MOUSE3.725e-5243.39L-aminoadipate-semialdehyde dehydrogenase-phosphop... [more]
sp|B2RYJ4|ADPPT_RAT2.118e-5137.59L-aminoadipate-semialdehyde dehydrogenase-phosphop... [more]
sp|Q9NRN7|ADPPT_HUMAN1.616e-4942.33L-aminoadipate-semialdehyde dehydrogenase-phosphop... [more]
sp|Q5NVE1|ADPPT_PONAB1.779e-4942.33L-aminoadipate-semialdehyde dehydrogenase-phosphop... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1L8HB195.583e-6741.55ACPS domain-containing protein OS=Xenopus laevis O... [more]
B1WB104.338e-6541.20LOC100145738 protein OS=Xenopus tropicalis OX=8364... [more]
A0A3M6UTV87.412e-6141.37ACPS domain-containing protein OS=Pocillopora dami... [more]
W4X9S41.256e-6039.72ACPS domain-containing protein OS=Strongylocentrot... [more]
A0A401NKN81.868e-6039.37ACPS domain-containing protein OS=Scyliorhinus tor... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
aasdhppt9.124e-6136.84aminoadipate-semialdehyde dehydrogenase-phosphopan... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
aasdhppt9.189e-6338.00aminoadipate-semialdehyde dehydrogenase-phosphopan... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO470522.797e-5841.80Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
aasdhppt1.033e-6137.19aminoadipate-semialdehyde dehydrogenase-phosphopan... [more]
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BLAST of L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000018744.10.000e+099.64SMESG000018744.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30030002 ID=SMED30030002|Name=L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase|organism=Schmidtea mediterranea sexual|type=transcript|length=1074bp
CGTGATTTGAAATATAAATTTTTAAATATTAGAATTATTATTAAAAATTA
ATATAATTTACTCATCATCAGACATGACAAAAATATTTTTGCGATATGCT
TTCAATTCATCTAGTTGGAATCCAAATAAACCTGAATGGTTGAAAGCTAT
GAGTTGTATTCAAACAGAAGAGCGTTACAGAATTACATCATATGCATATC
AGAGAGATGCTAAAGCATCATTAGCGGGAAGATTACTTGCTAGAAAAGTT
ATTACAGATTTACTGAATTTAAGTAATAATGTCGTTCGGTTGGAGCGAAC
CGAAAAAGGGCGACCTTTTCTAGTAGCACACGATCTTCCTCAATTAGCCA
ATTGTTTAGATTTTAATTTATCGCATCAGGGAGACTTTACAGTATTGACC
GCAGGTTTGGGCGTGAAAACCGGAGTGGATGTTATGAAAGTGCAACTACC
AGTATCAGAAAATTCCGTAGATGATTTCTTTGGATTAATGAAAAGACAAT
TCGCAGAAAAAGAATGGATATCCATTAATGATCCTGAAAAAGATATCGAT
AAAATGAGATTATTTTATCGGCATTGGTGTTTGAAAGAAAGTTATGTTAA
AGCATTAGGCATTGGAATTGGTATTGACTTAGAACAGATAATTTGCTCCA
TCTCCAACAACAGTGAACCCTGGGTTTCTTGGATTGACCAAGAAAAATCA
CTCTGGAAATTTGAGGAACATGTCTTGGATTCCGATCACGTTGTCGGAAT
AGCATGGCATGGTCAAAATGTACAGCAAGATGTAAAATTTGGCAATTTTG
TTCATTTGACCTTTGCTGAAATTCTCGCCAGCATGGAAACACTTCATCGG
GCAGAATCGGAATTTTGGATCAATTTTAAATCCAAGCAACCTTTACCACC
TTATTTAATGAAATCTAAATGAAAAAAAAAGAAAAATTGTAGATTAATAC
TTTTATAATTTTTGTATTAATTTTTAATTATTGGTTATTTATTCTTATTA
ACGGATTGGTGTTATGAATATTTTATCAACGTTCCTGAGTTGACTATTAT
TAATTAATTCGACTTTATTTATAA
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protein sequence of SMED30030002-orf-1

>SMED30030002-orf-1 ID=SMED30030002-orf-1|Name=SMED30030002-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=283bp
MTKIFLRYAFNSSSWNPNKPEWLKAMSCIQTEERYRITSYAYQRDAKASL
AGRLLARKVITDLLNLSNNVVRLERTEKGRPFLVAHDLPQLANCLDFNLS
HQGDFTVLTAGLGVKTGVDVMKVQLPVSENSVDDFFGLMKRQFAEKEWIS
INDPEKDIDKMRLFYRHWCLKESYVKALGIGIGIDLEQIICSISNNSEPW
VSWIDQEKSLWKFEEHVLDSDHVVGIAWHGQNVQQDVKFGNFVHLTFAEI
LASMETLHRAESEFWINFKSKQPLPPYLMKSK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0002056medial muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR0371434-PPantetheinyl_Trfase_dom_sf
IPR0082784-PPantetheinyl_Trfase_dom
Vocabulary: molecular function
TermDefinition
GO:0000287magnesium ion binding
GO:0008897holo-[acyl-carrier-protein] synthase activity
GO:0016740transferase activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
Vocabulary: biological process
TermDefinition
GO:0006633fatty acid biosynthetic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR0371434'-phosphopantetheinyl transferase domain superfamilyGENE3DG3DSA:3.90.470.20coord: 6..261
e-value: 1.9E-81
score: 274.8
IPR0371434'-phosphopantetheinyl transferase domain superfamilyGENE3DG3DSA:3.90.470.20coord: 114..231
e-value: 1.9E-81
score: 274.8
IPR0371434'-phosphopantetheinyl transferase domain superfamilySUPERFAMILYSSF562144'-phosphopantetheinyl transferasecoord: 14..107
IPR0371434'-phosphopantetheinyl transferase domain superfamilySUPERFAMILYSSF562144'-phosphopantetheinyl transferasecoord: 116..239
IPR0082784'-phosphopantetheinyl transferase domainPFAMPF01648ACPScoord: 117..227
e-value: 2.8E-17
score: 62.9
NoneNo IPR availablePANTHERPTHR12215PHOSPHOPANTETHEINE TRANSFERASEcoord: 6..267
NoneNo IPR availablePANTHERPTHR12215:SF10L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASEcoord: 6..267