Peptidase M60 domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny AppSub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029987 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Peptidase M60 domain-containing protein vs. TrEMBL
Match: A0A1S6KMG4 (Peptidase M60 domain-containing protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 365.925 bits (938), Expect = 1.284e-117 Identity = 182/228 (79.82%), Postives = 204/228 (89.47%), Query Frame = 1 Query: 1 LQILNIFNVDXXXXXXXXXXXXXXEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 684 LQILNIFNVDF N+F S SS +N+EMPDSMFS++LIGLED++ RMLLNHDYL+SKA L+ GL+ + +SML+NSK+ LI IIKKYE LLKWICPCDVQKATD NDRKLIRF GE++KNQ LAYSNFKAPCGDLFPGDFVASPPKVTV+LNL+G+TPST+NPIGYYLEAGSTLEYN+I SSGSWAISVGCHTDNLPDSL WARYPSI +YRIPIS GHIYSAFGG Sbjct: 347 LQILNIFNVDFLNTFISWSSPINSEMPDSMFSDNLIGLEDILSRMLLNHDYLLSKASLLNGLMSKYPASMLNNSKLSVILIAIIKKYESLLKWICPCDVQKATDLNDRKLIRFFGELLKNQALAYSNFKAPCGDLFPGDFVASPPKVTVRLNLVGITPSTDNPIGYYLEAGSTLEYNIIVSSGSWAISVGCHTDNLPDSLAGWARYPSITVYRIPISGIGHIYSAFGG 574
BLAST of Peptidase M60 domain-containing protein vs. TrEMBL
Match: A0A1S6KMG0 (Peptidase M60 domain-containing protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 171.4 bits (433), Expect = 2.819e-45 Identity = 86/227 (37.89%), Postives = 133/227 (58.59%), Query Frame = 1 Query: 4 QILNIFNVDXXXXXXXXXXXXXXEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 684 +I+N+FN+ ++ + S + DS F+E+ + L+ + +++ N+DYL+ + + +++N+K+ + +KKY+ L+ +ICPC ATD +DR +I G K+Q LA+S +K PC DLFP DF ++P V L + G T PIGYYL AG TL+Y + S+G W ISVGCH+D L + EW RYP I +P+S +G I+S FGG Sbjct: 356 KIMNMFNIASDTTYFTFGSSGEYTIKDSDFTEEFLDLKVRLRKLVDNYDYLLENGQFLLNSMNKMPPKIIENAKLDDVSKDFLKKYDYLISYICPCKDDPATDVSDRSIISIFGLFAKSQGLAHSKYKLPCIDLFPMDFKSAPKLKQVVLEVFGEIAYTRIPIGYYLPAGETLKYKIQASTGKWGISVGCHSDILGEKRSEWYRYPDIYTNSVPLSEEGTIFSPFGG 582
BLAST of Peptidase M60 domain-containing protein vs. TrEMBL
Match: A0A448WAZ0 (Peptidase M60 domain-containing protein OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS739 PE=4 SV=1) HSP 1 Score: 65.0846 bits (157), Expect = 1.624e-8 Identity = 50/181 (27.62%), Postives = 80/181 (44.20%), Query Frame = 1 Query: 208 MLDNSKMPEYLITIIKKYEKLLKWICPCDV---------QKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPK--VTVKLNL-IGVTPSTE-NPIGYYLEAGSTLEYNVI------GSSGS---WAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 684 ++ + + ++ +Y L+ ++ PC Q + R I ++ L Y+ K P FPGDF P T +L L + T S E + G+Y AG+T EY V GS W++ +GCHTD L + L W R+P I +R+P+ G +++ GG Sbjct: 224 LIQSESTSSLIANLLTRYSSLMDYVAPCPSRPFRGLTRGQPSLPLPHRHAILNFNRLVFAPSLRYTGLKLPGVSQFPGDFPTRPAHGLRTSQLFLEVNHTVSGEKHTTGFYAPAGATFEYEVAFVEPPGGSEDEPIGWSLEIGCHTDRL-EPLARWDRFPVIT-HRVPLELHGVVFTPVGG 402
BLAST of Peptidase M60 domain-containing protein vs. TrEMBL
Match: A0A448WDR5 (Peptidase M60 domain-containing protein OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS2683 PE=4 SV=1) HSP 1 Score: 61.2326 bits (147), Expect = 3.583e-7 Identity = 47/169 (27.81%), Postives = 77/169 (45.56%), Query Frame = 1 Query: 202 SSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNF---KAPC-GDL-FPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSG---SWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 684 +S +N++ E L + KY + PC +A ++ +R ++ Q +S K P G L FPGDF V++ + L+ + P P G Y +A Y +I +G + + +GCH+DN+ DS W R+P I+ R G +S +GG Sbjct: 17 TSTFENNEFQEELNKFLDKYYYFISERAPC---QARPFKSKENLREKTALLNYQNAIFSQIGPRKRPIPGYLNFPGDFAGPAEPVSLTIKLVQLHPDEFIPTGAYAKAMVEFYYKIIDRAGPIMDYTMIIGCHSDNIEDSTI-WKRWPKISHSRQLSKESGTYWSPYGG 181
BLAST of Peptidase M60 domain-containing protein vs. Planmine SMEST
Match: SMESG000042174.1 (SMESG000042174.1) HSP 1 Score: 434.106 bits (1115), Expect = 2.144e-147 Identity = 225/228 (98.68%), Postives = 226/228 (99.12%), Query Frame = 1 Query: 1 LQILNIFNVDXXXXXXXXXXXXXXEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 684 LQILNIFNVDFRNSFTSSSSVVNTEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKV VKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPIS+KGHIYS FGG Sbjct: 348 LQILNIFNVDFRNSFTSSSSVVNTEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKVIVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISDKGHIYSGFGG 575
BLAST of Peptidase M60 domain-containing protein vs. Planmine SMEST
Match: SMESG000042174.1 (SMESG000042174.1) HSP 1 Score: 433.335 bits (1113), Expect = 2.931e-147 Identity = 225/228 (98.68%), Postives = 226/228 (99.12%), Query Frame = 1 Query: 1 LQILNIFNVDXXXXXXXXXXXXXXEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 684 LQILNIFNVDFRNSFTSSSSVVNTEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKV VKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPIS+KGHIYS FGG Sbjct: 345 LQILNIFNVDFRNSFTSSSSVVNTEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKVIVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISDKGHIYSGFGG 572
BLAST of Peptidase M60 domain-containing protein vs. Planmine SMEST
Match: SMESG000042235.1 (SMESG000042235.1) HSP 1 Score: 426.017 bits (1094), Expect = 4.651e-145 Identity = 219/228 (96.05%), Postives = 223/228 (97.81%), Query Frame = 1 Query: 1 LQILNIFNVDXXXXXXXXXXXXXXEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 684 LQILNIFNVDF NS+TSSSSVVNTEMPDSMF +D IGLEDLVHRMLLNHDYLI KAPLVAGLLPIFSSSML+NSKMPEYLITIIKKYEKLLKWICPCDVQKAT+PNDRKLIRFLGEIMKNQ LAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG Sbjct: 285 LQILNIFNVDFLNSYTSSSSVVNTEMPDSMFIDDFIGLEDLVHRMLLNHDYLIRKAPLVAGLLPIFSSSMLNNSKMPEYLITIIKKYEKLLKWICPCDVQKATNPNDRKLIRFLGEIMKNQALAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 512
BLAST of Peptidase M60 domain-containing protein vs. Planmine SMEST
Match: SMESG000042170.1 (SMESG000042170.1) HSP 1 Score: 421.009 bits (1081), Expect = 2.013e-142 Identity = 215/228 (94.30%), Postives = 219/228 (96.05%), Query Frame = 1 Query: 1 LQILNIFNVDXXXXXXXXXXXXXXEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 684 LQILNIFNVDF NS+TS SSVVNTEMPDSMF +D IGLEDLVHRMLLNHDYLISKAPLV LL IFSSSML+NSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQ LAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPIS+KGHIYS FGG Sbjct: 348 LQILNIFNVDFLNSYTSWSSVVNTEMPDSMFIDDFIGLEDLVHRMLLNHDYLISKAPLVGSLLAIFSSSMLNNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQALAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISDKGHIYSGFGG 575
BLAST of Peptidase M60 domain-containing protein vs. Planmine SMEST
Match: SMESG000042170.1 (SMESG000042170.1) HSP 1 Score: 420.239 bits (1079), Expect = 3.414e-142 Identity = 215/228 (94.30%), Postives = 219/228 (96.05%), Query Frame = 1 Query: 1 LQILNIFNVDXXXXXXXXXXXXXXEMPDSMFSEDLIGLEDLVHRMLLNHDYLISKAPLVAGLLPIFSSSMLDNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQVLAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISNKGHIYSAFGG 684 LQILNIFNVDF NS+TS SSVVNTEMPDSMF +D IGLEDLVHRMLLNHDYLISKAPLV LL IFSSSML+NSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQ LAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPIS+KGHIYS FGG Sbjct: 345 LQILNIFNVDFLNSYTSWSSVVNTEMPDSMFIDDFIGLEDLVHRMLLNHDYLISKAPLVGSLLAIFSSSMLNNSKMPEYLITIIKKYEKLLKWICPCDVQKATDPNDRKLIRFLGEIMKNQALAYSNFKAPCGDLFPGDFVASPPKVTVKLNLIGVTPSTENPIGYYLEAGSTLEYNVIGSSGSWAISVGCHTDNLPDSLPEWARYPSINIYRIPISDKGHIYSGFGG 572 The following BLAST results are available for this feature:
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 4
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Peptidase M60 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029987 ID=SMED30029987|Name=Peptidase M60 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=685bpback to top protein sequence of SMED30029987-orf-1 >SMED30029987-orf-1 ID=SMED30029987-orf-1|Name=SMED30029987-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=228bp LQILNIFNVDFRNSFTSSSSVVNTEMPDSMFSEDLIGLEDLVHRMLLNHDback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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