Multidrug resistance-associated protein 1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029981 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8Note: Hover over icons to view figure legend
Homology
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 700.664 bits (1807), Expect = 0.000e+0 Identity = 447/1367 (32.70%), Postives = 733/1367 (53.62%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVADVNTMNFKRKLTSTLK--------SKNNYHTKSRRPINEHSSVW----------W---LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIR-----SVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI-SNDAI--DFMKI---------KSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIK-----SKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ I + NPCPE +S SRI F W+ I ++ ++ + ++ + V V N+K++ T K SK+ K ++ + V W L K L+ FG ++S+ H + FS P ILK L+KF++ + P + G+ + +T L ++ + FH+ + +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++IL L+ +G LA + V+VLM P+N++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + S V W P V L YV I N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + ++ + I ++N +F+W P L I SI +G LV +VG++ GK+SLL+A++ EM ++G V+IKGS++YVPQ WI+ S ++NI+ + E Y++VI+ C L DL + + G + SGGQ+QR++LARAVY ++IYL DDPLSA+DA V + +FE VI G+L N TR+ VT ++++L +D II + G I G + + D +F++ E + E+ N V + ++ + L +S S++H Q + + + E + V Y+ Y A G F SIF F + + S+YWL T DP + H + +YG +G Q I + + S+G AS+ +H +L+ +L+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + VIL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ + LNW++ ++ETN +A+ERL ++ E E + P S WP+ G++EF+ + L+Y ED F L +IN+ I GEK+GIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + +L L+HL ++ ++ L +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IV+D+GEI E+G S+++ ++S K
Sbjct: 199 SETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM--VPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS-GGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQ-----------KAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-----------------------IVNGTQEHTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1526
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 700.664 bits (1807), Expect = 0.000e+0 Identity = 447/1367 (32.70%), Postives = 733/1367 (53.62%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVADVNTMNFKRKLTSTLK--------SKNNYHTKSRRPINEHSSVW----------W---LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIR-----SVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI-SNDAI--DFMKI---------KSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIK-----SKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ I + NPCPE +S SRI F W+ I ++ ++ + ++ + V V N+K++ T K SK+ K ++ + V W L K L+ FG ++S+ H + FS P ILK L+KF++ + P + G+ + +T L ++ + FH+ + +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++IL L+ +G LA + V+VLM P+N++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + S V W P V L YV I N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + ++ + I ++N +F+W P L I SI +G LV +VG++ GK+SLL+A++ EM ++G V+IKGS++YVPQ WI+ S ++NI+ + E Y++VI+ C L DL + + G + SGGQ+QR++LARAVY ++IYL DDPLSA+DA V + +FE VI G+L N TR+ VT ++++L +D II + G I G + + D +F++ E + E+ N V + ++ + L +S S++H Q + + + E + V Y+ Y A G F SIF F + + S+YWL T DP + H + +YG +G Q I + + S+G AS+ +H +L+ +L+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + VIL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ + LNW++ ++ETN +A+ERL ++ E E + P S WP+ G++EF+ + L+Y ED F L +IN+ I GEK+GIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + +L L+HL ++ ++ L +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IV+D+GEI E+G S+++ ++S K
Sbjct: 199 SETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM--VPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS-GGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQ-----------KAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-----------------------IVNGTQEHTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1526
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 700.279 bits (1806), Expect = 0.000e+0 Identity = 446/1374 (32.46%), Postives = 739/1374 (53.78%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVADVNTMNFKRKLTSTLK--------SKNNYHTKSRRPINEHSSVW----------W---LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIR-----SVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI-SNDAI--DFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQ----------INIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEI-----------KSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ I + NPCPE +S SRI F W+ I ++ ++ + ++ + V V N+K++ T K SK+ K ++ + V W L K L+ FG ++S+ H + FS P ILK L+KF++ + P + G+ + +T L ++ + FH+ + +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++IL L+ +G LA + V+VLM P+N++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + S V W P V L YV I N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + ++ + I ++N +F+W P L I SI +G LV +VG++ GK+SLL+A++ EM ++G V+IKGS++YVPQ WI+ S ++NI+ + E Y++VI+ C L DL + + G + SGGQ+QR++LARAVY ++IYL DDPLSA+DA V + +FE VI G+L N TR+ VT ++++L +D II + G I G + + D +F++ + + E N + VM+ + + ++K + +++Q ++ + + ++ + K+E E V Y+ Y A G F SIF F + + S+YWL T DP + H + +YG +G Q I + + S+G AS+ +H +L+ +L+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + VIL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ + LNW++ ++ETN +A+ERL ++ E E + P S WP+ G++EF+ + L+Y ED F L +IN+ I GEK+GIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + +L L+HL ++ ++ L +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IV+D+GEI E+G S+++ ++S K
Sbjct: 98 SETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM--VPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS-GGKISEMGSYQELLARDGAFAEFLRTYA--------STEQEQDAEENGSTVMDEEEAGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-----------------------IVNGTQEHTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1435
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 700.279 bits (1806), Expect = 0.000e+0 Identity = 446/1374 (32.46%), Postives = 739/1374 (53.78%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVADVNTMNFKRKLTSTLK--------SKNNYHTKSRRPINEHSSVW----------W---LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIR-----SVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI-SNDAI--DFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQ----------INIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEI-----------KSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ I + NPCPE +S SRI F W+ I ++ ++ + ++ + V V N+K++ T K SK+ K ++ + V W L K L+ FG ++S+ H + FS P ILK L+KF++ + P + G+ + +T L ++ + FH+ + +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++IL L+ +G LA + V+VLM P+N++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + S V W P V L YV I N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + ++ + I ++N +F+W P L I SI +G LV +VG++ GK+SLL+A++ EM ++G V+IKGS++YVPQ WI+ S ++NI+ + E Y++VI+ C L DL + + G + SGGQ+QR++LARAVY ++IYL DDPLSA+DA V + +FE VI G+L N TR+ VT ++++L +D II + G I G + + D +F++ + + E N + VM+ + + ++K + +++Q ++ + + ++ + K+E E V Y+ Y A G F SIF F + + S+YWL T DP + H + +YG +G Q I + + S+G AS+ +H +L+ +L+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + VIL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ + LNW++ ++ETN +A+ERL ++ E E + P S WP+ G++EF+ + L+Y ED F L +IN+ I GEK+GIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + +L L+HL ++ ++ L +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IV+D+GEI E+G S+++ ++S K
Sbjct: 98 SETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM--VPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS-GGKISEMGSYQELLARDGAFAEFLRTYA--------STEQEQDAEENGSTVMDEEEAGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-----------------------IVNGTQEHTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1435
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 673.315 bits (1736), Expect = 0.000e+0 Identity = 416/1238 (33.60%), Postives = 686/1238 (55.41%), Query Frame = 2
Query: 893 HIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIR-----SVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI-SNDAI--DFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQ----------INIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEI-----------KSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
H + FS P ILK L+KF++ + P + G+ + +T L ++ + FH+ + +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++IL L+ +G LA + V+VLM P+N++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + S V W P V L YV I N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + ++ + I ++N +F+W P L I SI +G LV +VG++ GK+SLL+A++ EM ++G V+IKGS++YVPQ WI+ S ++NI+ + E Y++VI+ C L DL + + G + SGGQ+QR++LARAVY ++IYL DDPLSA+DA V + +FE VI G+L N TR+ VT ++++L +D II + G I G + + D +F++ + + E N + VM+ + + ++K + +++Q ++ + + ++ + K+E E V Y+ Y A G F SIF F + + S+YWL T DP + H + +YG +G Q I + + S+G AS+ +H +L+ +L+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + VIL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ + LNW++ ++ETN +A+ERL ++ E E + P S WP+ G++EF+ + L+Y ED F L +IN+ I GEK+GIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + +L L+HL ++ ++ L +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IV+D+GEI E+G S+++ ++S K
Sbjct: 9 HDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM--VPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS-GGKISEMGSYQELLARDGAFAEFLRTYA--------STEQEQDAEENGSTVMDEEEAGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-----------------------IVNGTQEHTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1210
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 667.922 bits (1722), Expect = 0.000e+0 Identity = 428/1349 (31.73%), Postives = 718/1349 (53.22%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTL---KSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFP-NYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRV-SLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEP-ILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISN-NGILANTTRLFVTQNINFLNYLDKIIFLDE---------------NGS------------IKYYGDVSNISNDAIDFMK-IKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINI--RKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYML-IYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNK--LTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
N CPE +S +++ F W Y + ++ E +D++ + A+ +F L + + K + ++ P N H S+ +F + L+ C + + F P +L+ L+ FI P++ G ++A+ ++ +L S+ + FH + +RS + SAVY+K++N++NEA+ T I+NLMS D +I + + S+P +I+L FL+ +G G ++L+ P NS +++ Q E+M++KD+RIK M+E+LN MKV+KLYSWE K++ REKE+ +++ +S + + W P V + YV P N V+T + TFV++ L N+LR P+AV + A+ S R+ F E + + S I++ GSF+W S E L I +I +G+LV IVG++ SGK+SLL+A++GEM L G+V + GS++YVPQ WI+ +S ++NI+ ++ Y Y+NVI C L DL + A++ G + SGGQ+QR++LARAVYQ +EI LLDDPLSA+D+ V + +FE VIS G L TR+ +T + +L + D++I L + NG+ K+ G + D+ + + ++ S + +S + ++N+ I LH ++ + I K+ L+ S K + E E V ++ Y YF A G + ++L V S+ +L + + D + S + ++ L IY ++G GQ C + +LG AS+ +H +L +++S + +F + +ILN F KDI+ ID +P+++ ++ IF V+++ FVI+ P + + +G +YF++L+FY+ ++ Q + L S SPI+ F E++QG IRA F E +++N Y V N WL++RL+ +GN++V S A+ +R+ L+ LVGL++SY+++I LNW + +LETN +A+ER++ + +E N+ + L P S WP G+I K F+++Y L+ + I EKIGIVGRTG+GK+SL +LF+++E GG + ID +I D+ + +R +T+ PQ+ +FSGT+R N+DPF D + +AL +HL +++S+ LH + G +LSVGQRQL+CLAR +LR +K++VLDEA A+VD ETD L+ +TI+ +F + T+L IAHR + + D D+++V+D+G + EF ++++NP+G F
Sbjct: 203 GKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYRRKIKKNPEAAIPKN-HPSILI---PIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAK---------------------EIALSGNGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIEAIDQTLPHSIRAMVMTIFNVISTVFVIIWATPWAGIGFLVLGFVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSL-APKS-WPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIF 1524
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-2 (pep chromosome:WBcel235:X:563719:572701:-1 gene:WBGene00003408.1 transcript:F57C12.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-2) HSP 1 Score: 665.996 bits (1717), Expect = 0.000e+0 Identity = 430/1357 (31.69%), Postives = 713/1357 (52.54%), Query Frame = 2
Query: 572 ENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRR------PINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFP-NYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRV-SLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNN-GILANTTRLFVTQNINFLNYLDKIIFLDEN---------------------------------GSIKYYGDVSNISNDAI-DFMKIKSE--KSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNK--LTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
++ + CPE +S +R+ F W Y + +++E +D++ A+ +F + L + + YH ++ P N S V +F + L+ + + + F P +LK L+ FI P++ G ++ + L S+ + +H + VRS + SAVYSK++N++NEA+ T I+NLMS D KI + S+P +I L FL+ +G A G++VL+ P+N + ++ QTE+M+ KD+RIK M+E+LN MKV+KLYSWE ++ + RE+E+++++ +S + W P + YV + P N V+T E TFV++ L ++LR P+A++ A+ VS R+ F E + S + S IE++NG FSW SD +P L+ I+ I KG+LV IVGK+ SGK+SLL+A++GEM L G+V I G+++YVPQ WI+ +S ++NI+ +K Y +Y++V++ C L DL A + G + SGGQ+QR++LARAVYQ +I LLDDPLSA+D+ V + +FE VIS++ G LA+ TR+ VT + +L + D++I L E G + GD S ++ + D ++K K ++ ++ TS +R+S R +LH+ R Q + + E E V ++ Y YF A F + + L +LS+++L KL+ H + A + IY ++G GQ + ++G AS+ +H +L +++S + +F + +ILN KDI+ ID +P+ + + IF V+A+ VI+ P + + ++YFI+L+FY+ ++ Q + L S SPI+ F E++QG IRA +F + + ++D+ Y V N WL++RL+ +GN++V + A+ +R+ L+ LVGL++SY+++I LNW + +LETN +++ER+ + +E N+ L WP G+I K F+++Y L+ I+ I EK+GIVGRTG+GK+SL +LF+++E GGS+ ID I+I ++ + +R +T+ PQ+ +FSGT++ N+DPF+ D + +AL +HL P+++S+ L + G +LSVGQRQL+CLAR +LR +K++VLDEA A+VD ETD LI +TI+ +F T+L IAHR + + D D+++V+D+G + EF ++ NP+G F
Sbjct: 202 KSESSCPEYTASFINRLTFQWFTGLAYLGNKKSLENEDLWDLNEIDKAENLIPSFMQNLKPRI---DEYHQNIKKDPSAALPKNHPSFVI----PIFKTYKYTLLAGFFYKLCFDMLQFLAPQLLKQLIGFIEDKNQPVWIGCSIVGIMFFSSFLQSMFLHQYYHSMFRLGMHVRSVLTSAVYSKALNLSNEARKGKTIGAIVNLMSVDIQKIQDMAPTIMLFWSAPLQIFLSIYFLWKFLGVAALAGLVVLILALPVNGLIAIQMRKCQTEQMKLKDERIKMMSEILNGMKVLKLYSWERSMENMVLKIRERELHILKKLSYFMAAIVFSWICAPFLASVISFVVYVYLDPENNVLTPEITFVALSLFDILRMPLAMVAMVYGEAVQCSVSNTRLKEFFAAEEMSPQTSISHGETDSAIEVENGLFSWSSDEDPTLREISFKIQKGQLVAIVGKVGSGKSSLLHALLGEMNKLSGSVQINGNIAYVPQQAWIQNMSLRNNILFNKPYDLENYEDVVKNCALKEDLANLPAGDRTEIGEKGINLSGGQKQRVSLARAVYQNPDIILLDDPLSAVDSHVGKHIFENVISSSTGCLASKTRVLVTHGLTYLKHCDQLIVLKEGTISELGTYQELLNNSGAFAEFLEEFLIEESKTRGRVASIGDGSGEVDEILRDLGQVKPGILKRLESHLSQESDKEDTSARAIEYSRDSSRRSVLLHSP----------RSQHEENEALLGAISEDVPAQENTQLIEKETVETGKVKFEVYIAYFQAISIPITLLFFFLYVGSSGLGILSNFYLAKLSD------------------------HAKSGNRTSSDAKMELGIYAVLGMGQSFVVLIASIILTIGVLRASRILHAGLLGNIMRSPMAFFDVTPIGRILNRIGKDIEAIDRTLPDVIRHMSMTIFNVVATLVVIMWATPWAGIAFAILSVIYFIVLRFYISTSRQLKRLESASRSPIYSHFQESIQGASSIRAFGVVDNFIKQSQQRVDDHLIAYYPSIVANRWLAVRLEMVGNLIVLSAAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVSVERIKEYTVTPTEGNNSRRL--AAKSWPEKGEISIKNFSVRYRPGLDLVLHGISAHIAPSEKVGIVGRTGAGKSSLTLALFRIIEADGGSIEIDGINIANLQLEQLRSCLTIVPQDPVLFSGTMKMNLDPFSAYSDSQVWEALENAHLKPFVKSLQDGLEHKISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLIQKTIREQFKECTVLTIAHRLNTVMDSDRLLVLDKGRVAEFDSPKNLLANPDGIF 1515
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 659.833 bits (1701), Expect = 0.000e+0 Identity = 428/1349 (31.73%), Postives = 715/1349 (53.00%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTL---KSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFP-NYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRV-SLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEP-ILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISN-NGILANTTRLFVTQNINFLNYLDKIIFLDE---------------NGS------------IKYYGDVSNISNDAIDFMK-IKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINI--RKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYML-IYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNK--LTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
N CPE +S +++ F W Y + ++ E +D++ + A+ +F L + + K + ++ P N H S+ +F + L+ C + + F P +L+ L+ FI P++ G ++A+ ++ +L S+ + FH + +RS + SAVY+K++N++NEA+ T I+NLMS D +I + + S+P +I+L FL+ +G G ++L+ P NS +++ Q E+M++KD+RIK M+E+LN MKV+KLYSWE K++ REKE+ +++ +S + + W P V + YV P N V+T + TFV++ L N+LR P+AV + A+ S R+ F E + + S I++ GSF+W S E L I +I +G+LV IVG++ SGK+SLL+A++GEM L G+V + GS++YVPQ WI+ +S ++NI+ ++ Y Y+NVI C L DL + A++ G + SGGQ+QR++LARAVYQ +EI LLDDPLSA+D+ V + +FE VIS G L TR+ +T + +L + D++I L + NG+ K+ G + D+ + + ++ S + +S + ++N+ I LH ++ + I K+ L+ S K + E E V ++ Y YF A G + ++L V S+ +L + + D + S + ++ L IY ++G GQ C + +LG AS+ +H +L +++S + +F + +ILN F KD+D +D+ IP +S I + +IL PL + L++P+ ++YF++L+FY+ ++ Q + L S SPI+ F E++QG IRA F E +++N Y V N WL++RL+ +GN++V S A+ +R+ L+ LVGL++SY+++I LNW + +LETN +A+ER++ + +E N+ + L P S WP G+I K F+++Y L+ + I EKIGIVGRTG+GK+SL +LF+++E GG + ID +I D+ + +R +T+ PQ+ +FSGT+R N+DPF D + +AL +HL +++S+ LH + G +LSVGQRQL+CLAR +LR +K++VLDEA A+VD ETD L+ +TI+ +F + T+L IAHR + + D D+++V+D+G + EF ++++NP+G F
Sbjct: 203 GKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYRRKIKKNPEAAIPKN-HPSILI---PIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAK---------------------EIALSGNGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDVDGVDTDIPRTMSMFIRTAVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSL-APKS-WPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIF 1524
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 658.677 bits (1698), Expect = 0.000e+0 Identity = 427/1349 (31.65%), Postives = 711/1349 (52.71%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTL---KSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFP-NYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRV-SLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEP-ILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISN-NGILANTTRLFVTQNINFLNYLDKIIFLDE---------------NGS------------IKYYGDVSNISNDAIDFMK-IKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINI--RKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYML-IYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNK--LTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
N CPE +S +++ F W Y + ++ E +D++ + A+ +F L + + K + ++ P N H S+ +F + L+ C + + F P +L+ L+ FI P++ G ++A+ ++ +L S+ + FH + +RS + SAVY+K++N++NEA+ T I+NLMS D +I + + S+P +I+L FL+ +G G ++L+ P NS +++ Q E+M++KD+RIK M+E+LN MKV+KLYSWE K++ REKE+ +++ +S + + W P V + YV P N V+T + TFV++ L N+LR P+AV + A+ S R+ F E + + S I++ GSF+W S E L I +I +G+LV IVG++ SGK+SLL+A++GEM L G+V + GS++YVPQ WI+ +S ++NI+ ++ Y Y+NVI C L DL + A++ G + SGGQ+QR++LARAVYQ +EI LLDDPLSA+D+ V + +FE VIS G L TR+ +T + +L + D++I L + NG+ K+ G + D+ + + ++ S + +S + ++N+ I LH ++ + I K+ L+ S K + E E V ++ Y YF A G + ++L V S+ +L + + D + S + ++ L IY ++G GQ C + +LG AS+ +H +L +++S + +F + +ILN F KDID ID +P+ + + I Q + F V ++ PL I + + Y+ +L+FY+ ++ Q + L S SPI+ F E++QG IRA F E +++N Y V N WL++RL+ +GN++V S A+ +R+ L+ LVGL++SY+++I LNW + +LETN +A+ER++ + +E N+ + L P S WP G+I K F+++Y L+ + I EKIGIVGRTG+GK+SL +LF+++E GG + ID +I D+ + +R +T+ PQ+ +FSGT+R N+DPF D + +AL +HL +++S+ LH + G +LSVGQRQL+CLAR +LR +K++VLDEA A+VD ETD L+ +TI+ +F + T+L IAHR + + D D+++V+D+G + EF ++++NP+G F
Sbjct: 203 GKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYRRKIKKNPEAAIPKN-HPSILI---PIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAK---------------------EIALSGNGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDIDVIDYRLPSCIMTFVGAIVQAVTIFAVPIYATPLSSFPITIVLIGYYFLLRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSL-APKS-WPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIF 1524
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Match: mrp-1 (pep chromosome:WBcel235:X:576318:587483:-1 gene:WBGene00003407.1 transcript:F57C12.5e.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:mrp-1) HSP 1 Score: 654.055 bits (1686), Expect = 0.000e+0 Identity = 427/1357 (31.47%), Postives = 711/1357 (52.39%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTL---KSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFP-NYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRV-SLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEP-ILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISN-NGILANTTRLFVTQNINFLNYLDKIIFLDE---------------NGS------------IKYYGDVSNISNDAIDFMK-IKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINI--RKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYML-IYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNL-------SEVINC-IFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNK--LTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
N CPE +S +++ F W Y + ++ E +D++ + A+ +F L + + K + ++ P N H S+ +F + L+ C + + F P +L+ L+ FI P++ G ++A+ ++ +L S+ + FH + +RS + SAVY+K++N++NEA+ T I+NLMS D +I + + S+P +I+L FL+ +G G ++L+ P NS +++ Q E+M++KD+RIK M+E+LN MKV+KLYSWE K++ REKE+ +++ +S + + W P V + YV P N V+T + TFV++ L N+LR P+AV + A+ S R+ F E + + S I++ GSF+W S E L I +I +G+LV IVG++ SGK+SLL+A++GEM L G+V + GS++YVPQ WI+ +S ++NI+ ++ Y Y+NVI C L DL + A++ G + SGGQ+QR++LARAVYQ +EI LLDDPLSA+D+ V + +FE VIS G L TR+ +T + +L + D++I L + NG+ K+ G + D+ + + ++ S + +S + ++N+ I LH ++ + I K+ L+ S K + E E V ++ Y YF A G + ++L V S+ +L + + D + S + ++ L IY ++G GQ C + +LG AS+ +H +L +++S + +F + +ILN F KD+D +D +P+N+ SE++ C +F A+ F I + + F IL+FY+ ++ Q + L S SPI+ F E++QG IRA F E +++N Y V N WL++RL+ +GN++V S A+ +R+ L+ LVGL++SY+++I LNW + +LETN +A+ER++ + +E N+ + L P S WP G+I K F+++Y L+ + I EKIGIVGRTG+GK+SL +LF+++E GG + ID +I D+ + +R +T+ PQ+ +FSGT+R N+DPF D + +AL +HL +++S+ LH + G +LSVGQRQL+CLAR +LR +K++VLDEA A+VD ETD L+ +TI+ +F + T+L IAHR + + D D+++V+D+G + EF ++++NP+G F
Sbjct: 203 GKNSCPEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYRRKIKKNPEAAIPKN-HPSILI---PIFKTYKFTLLAGGCYKLMFDLLQFVAPELLRQLISFIEDKNQPMWIGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNLMSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQMEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACAPFLVAVLTFGLYVLWDPENNVLTPQITFVALALFNILRFPLAVFAMVFSQAVQCSASNTRLKEFFAAEEMSPQTSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVAIVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNVIENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKHIFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEFLLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKDEQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIGIKIALVFFLVYVASSMLGVFSNLYLARWSDDAK---------------------EIALSGNGSSSETQIRLGIYAVLGMGQATSVCAASIIMALGMVCASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDMDVVDERLPDNIGDFLLTFSELVACVVFTSYATPFAIFPIVLIAIGC--------FAILRFYVSTSRQLKRLESASRSPIYSHFQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAVYFRDSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEGNNSQSL-APKS-WPENGEISIKNFSVRYRPGLDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALFRIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNAHLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKTIREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNPDGIF 1524
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090025) HSP 1 Score: 659.833 bits (1701), Expect = 0.000e+0 Identity = 426/1369 (31.12%), Postives = 706/1369 (51.57%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ--C--VADVNTMNFKRKLTSTLKSKNNYHTKSR---------RPINEHSS----VWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPET-PLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFL-IENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLN-----YLDKIIFLDENGS-----------------------------------IKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFN-DKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
N PE +S SRI + W D+ ++N ++ + +D+ Q C V + ++ + + K+K K++ P E + + + ++ FG + +F +F++P +L ++ F+ A + P + G A+ + + FH L++R+A+ +A+Y K++ I+N K T EI+NLM+ D + + Y ++ S+P +I L FL+ ++G G+ V++ P+N + S ++ YQ +M++KD+R+K M EVL+ +KV+KLY+WE F K + R+KE+ +R + + + +W P V L TYV I N V+ A TFVS+ L N+LR P+ +LP IT + VS+ R++ FL E N + I+NG FSW E L+ INI + KG LV +VG + SGK+S++ A +GEM L G V+ G ++YVPQ WI+ + +DNI+ + Y Y VI C L D+ A +L G + SGGQ+QRI+LARAVY +++YLLDDPLSA+DA V + +FE+VI GILA +R+ VT + FL Y+ K+ + E+G+ I DV + +K+ +S SD + TS ++ + S R S S +++K+ + + E ++ V + Y Y + G ++ + Q+ S+ WL + +D N+ + + Y+ +YG GFGQ + F L +LG+ +A+K +H +L VL++ + F + +IL+ FSKD++++D +P +++ I C F+V+A+ VI + P+FL +IVPI LY+ +FY+ ++ Q L S SPI+ F+ET+ G IRA F E ++ N Y + N WL++RL+ +GN+++ + + A+ + P LVGL++SY++ + LNW++ D+ETN +++ER+ + + E + E + WP+ G++EF+ F ++Y E L ++ I+ GEK+GIVGRTG+GK+SL +LF+++E GG + ID +DI + + +R +T+ PQ+ +FSG++R N+DPF D + +AL LSHL +++S+ L+ + + G +LSVGQRQL+CLAR +LR +K++VLDEATA+VD ETD LI +TI+ F T+L IAHR + + D DK+IV+D+G+IIEF +E+++NP F
Sbjct: 220 GENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSW--GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSIS------VTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKK----------------QEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNV-------------------------ANDTGLRDMYLGVYGAFGFGQGFTSFFSDLAPALGSLHAAKVLHSMLLENVLRAPMTMFDTTPVGRILSRFSKDVESVDQKMPQVINDCIWCAFEVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1538
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090026) HSP 1 Score: 658.292 bits (1697), Expect = 0.000e+0 Identity = 427/1370 (31.17%), Postives = 704/1370 (51.39%), Query Frame = 2
Query: 572 ENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ--C--VADVNTMNFKRKLTSTLKSKNNYHTKSR---------RPINEHSS----VWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPET-PLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFL-IENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLN-----YLDKIIFLDENGS-----------------------------------IKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFN-DKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
N PE +S SRI + W D+ ++N ++ + +D+ Q C V + ++ + + K+K K++ P E + + + ++ FG + +F +F++P +L ++ F+ A + P + G A+ + + FH L++R+A+ +A+Y K++ I+N K T EI+NLM+ D + + Y ++ S+P +I L FL+ ++G G+ V++ P+N + S ++ YQ +M++KD+R+K M EVL+ +KV+KLY+WE F K + R+KE+ +R + + + +W P V L TYV I N V+ A TFVS+ L N+LR P+ +LP IT + VS+ R++ FL E N + I+NG FSW E L+ INI + KG LV +VG + SGK+S++ A +GEM L G V+ G ++YVPQ WI+ + +DNI+ + Y Y VI C L D+ A +L G + SGGQ+QRI+LARAVY +++YLLDDPLSA+DA V + +FE+VI GILA +R+ VT + FL Y+ K+ + E+G+ I DV + +K+ +S SD + TS ++ + S R S S +++K+ + + E ++ V + Y Y + G ++ + Q+ S+ WL + +D N+ + + Y+ +YG GFGQ++ L SLG +++ +H+ +L+ L+ ++ F + +I+N FSKD+D ID+ +P NL VI +F V+A+ VI + P+FL +IVPI LY+ +FY+ ++ Q L S SPI+ F+ET+ G IRA F E ++ N Y + N WL++RL+ +GN+++ + + A+ + P LVGL++SY++ + LNW++ D+ETN +++ER+ + + E + E + WP+ G++EF+ F ++Y E L ++ I+ GEK+GIVGRTG+GK+SL +LF+++E GG + ID +DI + + +R +T+ PQ+ +FSG++R N+DPF D + +AL LSHL +++S+ L+ + + G +LSVGQRQL+CLAR +LR +K++VLDEATA+VD ETD LI +TI+ F T+L IAHR + + D DK+IV+D+G+IIEF +E+++NP F
Sbjct: 219 RGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSW--GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSIS------VTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKK----------------QEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNV-------------------------ANDTGLRDMYLGVYGAFGFGQVVTGYLSTLILSLGCVYSARYMHNVLLHGTLRWPMEMFDITPLGRIVNRFSKDVDTIDNTLPLNLRVVILQLFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1538 HSP 2 Score: 67.781 bits (164), Expect = 8.441e-11 Identity = 62/260 (23.85%), Postives = 122/260 (46.92%), Query Frame = 2
Query: 1754 ENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKG-------------SMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELNGVDRMLCSG------GQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSE 2476
+NK KN+ Q+ R +E +N +R + +L+ ++ +I GE VGIVG+ +GK+SL A+ + G +SI G ++ +PQ+P + S + N+ + +++ + + L +++ A G++ + G GQRQ + LARA+ +K+++ +LD+ +A+D + + +K I T L + +N + DK+I LD+ I++ + N F + +
Sbjct: 1297 KNKPKNW---PQEGR--VEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAA----GLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVD-LETDDLIQKTIRTE--FKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKD 1544
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090023) HSP 1 Score: 655.596 bits (1690), Expect = 0.000e+0 Identity = 427/1370 (31.17%), Postives = 703/1370 (51.31%), Query Frame = 2
Query: 572 ENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ--C--VADVNTMNFKRKLTSTLKSKNNYHTKSR---------RPINEHSS----VWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPET-PLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFL-IENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLN-----YLDKIIFLDENGS-----------------------------------IKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFN-DKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
N PE +S SRI + W D+ ++N ++ + +D+ Q C V + ++ + + K+K K++ P E + + + ++ FG + +F +F++P +L ++ F+ A + P + G A+ + + FH L++R+A+ +A+Y K++ I+N K T EI+NLM+ D + + Y ++ S+P +I L FL+ ++G G+ V++ P+N + S ++ YQ +M++KD+R+K M EVL+ +KV+KLY+WE F K + R+KE+ +R + + + +W P V L TYV I N V+ A TFVS+ L N+LR P+ +LP IT + VS+ R++ FL E N + I+NG FSW E L+ INI + KG LV +VG + SGK+S++ A +GEM L G V+ G ++YVPQ WI+ + +DNI+ + Y Y VI C L D+ A +L G + SGGQ+QRI+LARAVY +++YLLDDPLSA+DA V + +FE+VI GILA +R+ VT + FL Y+ K+ + E+G+ I DV + +K+ +S SD + TS ++ + S R S S +++K+ + + E ++ V + Y Y + G ++ + Q+ S+ WL + +D N+ + + Y+ +YG GFGQ+ F LT +LG SK +H+ +L+ V + ++ F + +++N FSKD+D ID+++P VI+ F V+A+ VI + P+FL +IVPI LY+ +FY+ ++ Q L S SPI+ F+ET+ G IRA F E ++ N Y + N WL++RL+ +GN+++ + + A+ + P LVGL++SY++ + LNW++ D+ETN +++ER+ + + E + E + WP+ G++EF+ F ++Y E L ++ I+ GEK+GIVGRTG+GK+SL +LF+++E GG + ID +DI + + +R +T+ PQ+ +FSG++R N+DPF D + +AL LSHL +++S+ L+ + + G +LSVGQRQL+CLAR +LR +K++VLDEATA+VD ETD LI +TI+ F T+L IAHR + + D DK+IV+D+G+IIEF +E+++NP F
Sbjct: 219 RGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSW--GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSIS------VTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKK----------------QEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVA-------------------------NDTGLRDMYLGVYGAFGFGQVTSYFFCSLTLALGCIFCSKVLHETLLSYVFRWPMELFDTTPLGRVVNRFSKDVDTIDNVLPMLWRMVISQAFAVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1538
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090022) HSP 1 Score: 654.44 bits (1687), Expect = 0.000e+0 Identity = 428/1370 (31.24%), Postives = 701/1370 (51.17%), Query Frame = 2
Query: 572 ENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ--C--VADVNTMNFKRKLTSTLKSKNNYHTKSR---------RPINEHSS----VWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPET-PLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFL-IENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLN-----YLDKIIFLDENGS-----------------------------------IKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFN-DKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
N PE +S SRI + W D+ ++N ++ + +D+ Q C V + ++ + + K+K K++ P E + + + ++ FG + +F +F++P +L ++ F+ A + P + G A+ + + FH L++R+A+ +A+Y K++ I+N K T EI+NLM+ D + + Y ++ S+P +I L FL+ ++G G+ V++ P+N + S ++ YQ +M++KD+R+K M EVL+ +KV+KLY+WE F K + R+KE+ +R + + + +W P V L TYV I N V+ A TFVS+ L N+LR P+ +LP IT + VS+ R++ FL E N + I+NG FSW E L+ INI + KG LV +VG + SGK+S++ A +GEM L G V+ G ++YVPQ WI+ + +DNI+ + Y Y VI C L D+ A +L G + SGGQ+QRI+LARAVY +++YLLDDPLSA+DA V + +FE+VI GILA +R+ VT + FL Y+ K+ + E+G+ I DV + +K+ +S SD + TS ++ + S R S S +++K+ + + E ++ V + Y Y + G ++ + Q+ S+ WL + +D N+ + + Y+ +YG GFGQ+ F L SLG S+ +H +L L+ ++ F + +I+N FSKDID ID+++P N+ VI + V+A+ VI + P+FL +IVPI LY+ +FY+ ++ Q L S SPI+ F+ET+ G IRA F E ++ N Y + N WL++RL+ +GN+++ + + A+ + P LVGL++SY++ + LNW++ D+ETN +++ER+ + + E + E + WP+ G++EF+ F ++Y E L ++ I+ GEK+GIVGRTG+GK+SL +LF+++E GG + ID +DI + + +R +T+ PQ+ +FSG++R N+DPF D + +AL LSHL +++S+ L+ + + G +LSVGQRQL+CLAR +LR +K++VLDEATA+VD ETD LI +TI+ F T+L IAHR + + D DK+IV+D+G+IIEF +E+++NP F
Sbjct: 219 RGENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSW--GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSIS------VTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKK----------------QEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVA-------------------------NDTGLRDMYLGVYGAFGFGQVATNFFSSLAISLGCLKCSQLLHQTLLYYNLRWPMELFDTTPLGRIVNRFSKDIDTIDNVLPFNIRVVIGQAYMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1538 HSP 2 Score: 67.781 bits (164), Expect = 1.034e-10 Identity = 62/260 (23.85%), Postives = 122/260 (46.92%), Query Frame = 2
Query: 1754 ENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKG-------------SMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELNGVDRMLCSG------GQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSE 2476
+NK KN+ Q+ R +E +N +R + +L+ ++ +I GE VGIVG+ +GK+SL A+ + G +SI G ++ +PQ+P + S + N+ + +++ + + L +++ A G++ + G GQRQ + LARA+ +K+++ +LD+ +A+D + + +K I T L + +N + DK+I LD+ I++ + N F + +
Sbjct: 1297 KNKPKNW---PQEGR--VEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAA----GLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVD-LETDDLIQKTIRTE--FKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAFYSMAKD 1544
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Match: MRP (gene:FBgn0032456 transcript:FBtr0090021) HSP 1 Score: 650.973 bits (1678), Expect = 0.000e+0 Identity = 424/1370 (30.95%), Postives = 699/1370 (51.02%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ--C--VADVNTMNFKRKLTSTLKSKNNYHTKSR---------RPINEHSS----VWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPET-PLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFL-IENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLN-----YLDKIIFLDENGS-----------------------------------IKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS--SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFN-DKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
N PE +S SRI + W D+ ++N ++ + +D+ Q C V + ++ + + K+K K++ P E + + + ++ FG + +F +F++P +L ++ F+ A + P + G A+ + + FH L++R+A+ +A+Y K++ I+N K T EI+NLM+ D + + Y ++ S+P +I L FL+ ++G G+ V++ P+N + S ++ YQ +M++KD+R+K M EVL+ +KV+KLY+WE F K + R+KE+ +R + + + +W P V L TYV I N V+ A TFVS+ L N+LR P+ +LP IT + VS+ R++ FL E N + I+NG FSW E L+ INI + KG LV +VG + SGK+S++ A +GEM L G V+ G ++YVPQ WI+ + +DNI+ + Y Y VI C L D+ A +L G + SGGQ+QRI+LARAVY +++YLLDDPLSA+DA V + +FE+VI GILA +R+ VT + FL Y+ K+ + E+G+ I DV + +K+ +S SD + TS ++ + S R S S +++K+ + + E ++ V + Y Y + G ++ + Q+ S+ WL + +D N+ + + Y+ +YG GFGQ + A F + LG A+K IH+ +L +++ + F + ++LN FS D+D +D +P + + IF V+A+ VI + P+FL +IVPI LY+ +FY+ ++ Q L S SPI+ F+ET+ G IRA F E ++ N Y + N WL++RL+ +GN+++ + + A+ + P LVGL++SY++ + LNW++ D+ETN +++ER+ + + E + E + WP+ G++EF+ F ++Y E L ++ I+ GEK+GIVGRTG+GK+SL +LF+++E GG + ID +DI + + +R +T+ PQ+ +FSG++R N+DPF D + +AL LSHL +++S+ L+ + + G +LSVGQRQL+CLAR +LR +K++VLDEATA+VD ETD LI +TI+ F T+L IAHR + + D DK+IV+D+G+IIEF +E+++NP F
Sbjct: 220 GENEIPELSASFLSRITYQWFDKMALKGYRNPLEEKDLWDLRPQDSCSEVMPIFAHHWNQNVRKNYKNKARVEPKAQFSNGNVTFENPHGEKNGRKKGMASIMPPIYKSFGGVFLFGALMKLFTDTLTFAQPQVLSLIISFVEAQDAEPEWKGILYAVLLFVLAAAQTFILGQYFHRMFIVGLRIRTALINAIYRKALRISNSTKKESTVGEIVNLMAVDAQRFMELTTYLNMIWSAPLQIGLALYFLWQQLGPSVLAGLAVMIILIPVNGVIASRIKTYQIRQMKYKDERVKLMNEVLSGIKVLKLYAWEPSFEKQVLDIRDKEIATLRSTAYLNAGTSFLWSCAPFLVSLVTFATYVLIDENNVLDATKTFVSLSLFNILRFPLTMLPMLITNLVQTQVSVNRINKFLNSEELDPNSVLHDSSKPHPMSIENGEFSW--GDEITLRNINIEVKKGSLVALVGTVGSGKSSVVQAFLGEMEKLAGVVNTVGKLAYVPQQAWIQNATVRDNILFGQTYDRKRYNKVIDACALRADIDILSAGDLTEIGEKGINLSGGQKQRISLARAVYSDADLYLLDDPLSAVDAHVGKHIFEEVIGPKGILARKSRVLVTHGVTFLPQVDSIYVIKMGEISESGTFDQLVKNKGAFADFIIQHLQEGNEEEEELNQIKRQISSTADVPELLGTVEKAIKLARTESLSDSIS------VTSADSLMGGGGSLRRRTKRQDSHDSVASAASLKKK----------------QEVEGKLIETEKSQTGGVEFAVYKHYIKSVGIFLSVATLVLNFVFQAFQIGSNLWLTQWANDQNVA-------------------------NDTGLRDMYLGVYGAFGFGQGVLAYFAVVIVYLGGFQAAKTIHNELLAVIIRGSVCRFFDITPIGRLLNSFSGDMDVVDEELPATMDSFMTFIFMVLATIVVISLSTPIFLAVIVPIAFLYYFAQRFYVATSRQLMRLESVSRSPIYSHFSETVTGASTIRAYNVGDRFIEESDAKVDKNQVCKYPSVIANRWLAIRLEMVGNLIILFASLFAVL-GGQTNPGLVGLSVSYALQVTQTLNWLVRMSSDIETNIVSVERIKEYGETKQEAPWELEQDKNKPKNWPQEGRVEFQNFQVRYREGLDLVLRGVSFNIQGGEKVGIVGRTGAGKSSLTLALFRIIEAAGGRISIDGVDIASMGLHMLRSRLTIIPQDPVLFSGSLRINLDPFEIKTDDEIWKALELSHLKSFVKSLAAGLNHEIAEGGENLSVGQRQLVCLARALLRKTKVLVLDEATAAVDLETDDLIQKTIRTEFKECTVLTIAHRLNTILDSDKVIVLDKGQIIEFASPTELLDNPKSAF 1539
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:ZFIN;Acc:ZDB-GENE-050517-15]) HSP 1 Score: 704.901 bits (1818), Expect = 0.000e+0 Identity = 456/1364 (33.43%), Postives = 733/1364 (53.74%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVA-----------DVNTMNFKRKLTSTL---KSKNNYHTKSRRPINEHSSVWWLTKAL------------FHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFG-FTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLI------ENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKI----------KSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARG-SLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ V++++NPCPE +S S+I F W+ + ++ ++ + + ++ + + D + KR + TL K K +P+ E + L KAL FG ++S + H + F P IL+ L+ F++ P + G F A+ F+ T + + I Q FH+ T +++R+AI AVY K++ I N A+ T T EI+NLMS D + + I Y ++ S+P ++IL FL+ +G+ LA + V+VLM PLN++ + YQ +M+ KD RIK M EVLN +KV+KLY+WE F +S RE E+ +++ ++ + W P V L+ YV + N ++ A+ FVS+ L N+LR P+ +LP I+ + VS++R+ +FL +N + S D I I +G+FSW D P LKRIN+SI +G LV +VG + SGK+SLL+A++GEM +G+VSIKGS++YVPQ WI+ + KDNI+ ++ ++ Y+ V+ C L DL + G + SGGQ+QR+++ARAVY +YLLDDPLSA+DA V + +FEKVI G+L TR+ VT ++FL D I+ + +G I G + + F + + E+S D + + R S L+A+ K Q ++ + + + +E V +++Y A G L +F SIF F + + S+YWL T DP + + + +YG +G Q I + ++ S+G AS+ +H ML VL+S + +F ++ S ++N F+K+ D IDS+IP+ + + +F V+ S VIL PL ++I P+GLLYF + +FY+ S+ Q + L S SP++ FNETL G VIRA +++ F E ++ N K + V N WL++RL+F+GN +V + + A+ RN L+P ++GL+ISY++ + LNW++ +LETN +A+ER+ + E E K + WP G IE KF L+Y ED + + +I++ I GEK+GIVGRTG+GK+SL LF+++E G + ID ++I D+ + ++R IT+ PQ+ +FSG++R N+DPF+ D + ++L L+HL ++ + L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D +++V+D+G++ EF S +I ++ K
Sbjct: 199 SEVVKDSNPCPESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVKVKRPVDKTLYSPKRSTRGEKKDGQPVEESEIL--LAKALQKTGEPSLFFALCRTFGPYFLVSSLYKIIHDVLMFVGPEILRLLILFVNDSSAPTWHGYFYTALLFVCTCLQTLILQKY-FHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGASVLAGVAVMVLM--VPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVSAIRESELRVLKKMAYLGAISTFTWVCAPFLVALSTFAVYVLVDENNILDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMQRLRVFLSHEELDDDNVERPAISGTPD---SIRIADGAFSWSKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSFLPQADLILVM-VDGEITEMGSYTELLGRQGAFAEFLRTYTNTEQEEGEESLGDAVPRKG---LENGGPAALLRQS---QISLNATGAGKTTQ--------KTEANDDAAATKTKSAEASRLTEADKANTGRVKLSVFWEYMKAIGLPLSIF-SIFLFFCHHLSSLGSNYWLSLWTDDPVV-------------------------NNTQPKREMRLGVYGALGISQGIAVFCYSVSVSVGGILASRYLHQTMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARNNLSPGIMGLSISYALQVTASLNWLVRMSSELETNIVAVERVKEYGDTEKEAEWKLENSNLPPGWPTAGHIEIHKFGLRYREDLELAICDISVNIAGGEKVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRMNLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAKKGIFYKMAK 1513 HSP 2 Score: 86.2705 bits (212), Expect = 2.544e-16 Identity = 71/274 (25.91%), Postives = 127/274 (46.35%), Query Frame = 2
Query: 3698 SMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI---KHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLY 4510
S++++RL F + E E +D S P +I F+ + +D L IN+ I G + +VG GSGK+SL+ +L + GS+ ++ ++ PQ++ I + T++ NI +D ++ + L P LE + G + G+ G +LS GQ+Q + +AR + N + +LD+ ++VD + I E + + T +++ H S L D I+VM GEI E G +E++ + + Y
Sbjct: 609 SVSMQRLRVFLSHE-ELDDDNVERPAISGTPDSIRIADGAFS--WSKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGSV-------------SIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRTRVLVTHGLSFLPQADLILVMVDGEITEMGSYTELLGRQGAFAEFLRTY 866
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:ZFIN;Acc:ZDB-GENE-050517-16]) HSP 1 Score: 691.034 bits (1782), Expect = 0.000e+0 Identity = 431/1386 (31.10%), Postives = 719/1386 (51.88%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSE-------------------STFDVHYQCVADVNTMNFKRKLTSTLK---SKNNY---------------HTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENK--TKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSD---------------------PFAEHTESIFTSNNNCVMN---RNSCRIHKILHASIK-----SKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+S + + N CPE + SR+ F W R +++ ++++ + ++V + N K ++T T +++N+ KSR+P S +W AL FG +I + + +F P +L+ L+ F + P ++G+ LA T +L ++ + F T +++R+ I A+Y K++ I NEAK + T E++NLMS D + + + ++ S+P +I L FL+ +G GV V++ P N+ + YQ E+M++KD RIK M E+LN +KV+KLY+WE F I + R+KE++++R + S + + W + P V LT +VN+ V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ FL ++ ++ + + NG FSW + IL IN+ + +G L+ +VG + GKTSL++A++GEM LDG +SI+GS++YVPQ WI+ + +DNI+ + Y+E Y+ V+ C L DL +L G + SGGQRQR++LARA+Y ++++YLLDDPLSA+DA VA+ +F+ VI G L TR+ VT I+FL ++ I+ L +G + G ++ F + S D + HT+ + +N V+N R R I+ ++ S+ + + RK + + + TE V + Y++Y A G L F +G + + +++WL + T+D + +Y +G Q I F T +LG A++ +H +L ++ +F + + +I+N FSKDI +D ++P+ L + F +++ VI+ + P+F +I P+ L+YF + +FY+ ++ Q + L S SPI+ F+E++ G VIRA + F +++N K Y V N WL +R++F+GN +V + + A+ ++KL+P LVGL++SY++ + LNWM+ DLE+N +A+ER+ ++ ++E + P +WP G +EF ++++Y E L NI+L + GEKIGIVGRTG+GK+S+ LF+L+E G ++IDD+ I +I + D+R +T+ PQE +FSGT+R N+DPF D + +AL LSHL ++ + L +C + G +LSVGQRQL+CLAR +LR ++I+VLDEATA+VD ETD LI TI+ F + T+ IAHR + + D +++V+D+G+I EF + ++N +F K
Sbjct: 193 SSAVMDPNVCPETTAGFLSRMTFWWFTRMAIKGYKSPLENKDLWSLNKNDSSELVVPGLLNQWEVEKSKAHSSDDQNVKEQVTFTKPGSGAESNHVNESPEEAEVLLSKQQQKSRQP----SFLW----ALLRAFGPYFLIGSAFKLLQDLITFINPQLLRMLIAFTKQSDVPSWWGYALAFLMFGTSLLQTLILHQHFQYCFVTGMRLRTGIIGAIYRKALVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIFLALFFLWQNLGPSVLAGVAVMVLLIPFNAFIAMKTRTYQVEQMKYKDDRIKLMNEILNGIKVLKLYAWEPSFRDKILQIRQKELHVLRKTAYLSALSTMAWTSAPFLVALTSFAVFVNVDEKNVLDAEKAFVSLSLFNILRFPLNMLPQVISSIVQASVSLKRLQDFLNHDELDPESVDRKSNTTEYAVSVVNGKFSWAKRDQVILDNINVLVPQGSLLAVVGHVGCGKTSLISALLGEMEKLDGQISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLLDDPLSAVDAHVAKHIFDHVIGPEGALKGKTRILVTHGISFLPQVNNILVL-VDGRVSEMGSYQDLLRQNGAFAEFLRNYSLEDIIEDDELTVSFDEEEEEFPEDALSNHTDMV---DNEPVVNEARRQFMRQMSIMSNDVENPKKMSRRRRCSERKH--------PETPTEKKEPKVEKLIQAETTETGRVKLQVYWEYVKAIGPLLALFICFLYGCQSAAAIGANFWLSEWTND-------------------------ALHNRTQEMLQTRVGVYAALGISQGILVMFSSFTLALGKIQAARKLHQVLLENKFQTPQSFFDTTPTGRIINRFSKDIYVVDEVLPSTLLMFLGTFFASLSTMIVIISSTPVFAFVIAPLALIYFFVQRFYVATSRQLKRLESVSRSPIYSHFSESITGTSVIRAYGRNAAFVLMSDNKVDENQKSYYPGIVSNRWLGVRIEFIGNCIVLFAALFAVTGKDKLSPGLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETQTEAPWEVLEKKPPPDWPPLGNVEFVDYSVRYREGLDLVLKNISLKVRGGEKIGIVGRTGAGKSSMTLCLFRLLEAAAGEIVIDDVKISEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFERYSDEEVWKALELSHLQKFVTNQAAKLELECSEGGENLSVGQRQLVCLARALLRKTRILVLDEATAAVDLETDDLIQSTIRTEFQDCTVFTIAHRLNTIMDYTRVLVLDKGQIAEFDTPTNLMNQKGLFFGMAK 1533
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc6b.2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-110208-2]) HSP 1 Score: 689.878 bits (1779), Expect = 0.000e+0 Identity = 441/1326 (33.26%), Postives = 702/1326 (52.94%), Query Frame = 2
Query: 578 NNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKS--RRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTK--------NYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESE----FNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
NPCP E +S S++LF W R + YQC+ + T+ TL K + K R+ E + + L + L +F + +V FS P +L LL ++ + PL+ G+ A S + L S+ + + T ++V++A+ VY KS+ IN+ A+ T T EI+NL+S DT K+V + Y + +P EI L FL+ +G G+ ++ FPLN Q +M+ KD+RIK M E+L+ +K++K Y+WE F + + REKE+N ++ + V +++ + + M YV I +V+ A+ FVS+ L+N+L++P++ LP ++ M VSLKR+ FL +++ K + F S DI SV+ I NG+FSW DS P L+RIN+ + +G LV +VG + SGK+SLL+A++GEM G ++I GS+ YVPQ WI+ + KDNI+ + ++ Y+ V+ C L DL A + G + SGGQ+QR++LARAVY+ S+IYLLDDPLSA+DA V Q +FEKVI NG L N TR+ VT ++FL D I+ + +G IK G + + + F ++ K+FS +E ES A++K K I MV + + V + Y +YF G + IF + + + +YWL DP I + + +YG +GF Q I + SLG AS+ +H +LN VL S + +F + S +LN FSK+ID ID +IP+ L ++ +F+++ ++L P ++I+P+ LLY I FY+ ++CQ + L S SPI+ FNET+QG VIRA ++ F + ++ N + + V + WL++ L+FLGN+LV + I+++ R L+P VGL +S+S+ + +L+W++ + D+E N +++ER+ + E F D S+WPR G I F+ + L+Y + + L I+L + EK+GIVGRTG+GK+SL +F+++E G + ID I+I +I + ++R IT+ PQ+ +FSG++R N+DPF+ D + ++L L+HL ++ + L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD +TD LI TI+ +F + T+L IAHR + + D ++IVMDRG I E S +I+ ++ C+
Sbjct: 205 KNPCPVEDASFLSKLLFWWYGRLVVK--------------GYQCLIKIITIPSSLNEAQTLGFKLSSCVKQLFRKLFKEQCTGFVLFRTLAKIFSPYFLTGTLFLVIQDALMFSIPQVLSLLLGYVRDEDAPLWKGYLFAFSLFLLSCLQSLFNHQYMYTCLTVGMRVKTAVMGLVYRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQHLGPSTLAGITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRERVLGYREKELNALKKSQILYSVSIASFNSSTLLIAFAMFGVYVLIDDKHVLDAQKIFVSMALINILKAPLSQLPIAMSTTMQVVVSLKRLGTFLDQDELKLDSKKLIGSLFISLSDIESVV-INNGTFSWSKDSTPCLRRINVKVQRGSLVAVVGHVGSGKSSLLSAMLGEMEKKSGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLEILPARDATEIGEKGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGSLKNKTRVLVTHGLSFLPQADLILVM-ADGEIKEMGSYAELLSRKNAFAEL---KAFS--VSERKES----------------------ATLKGK-----IEFPATMVTLYLLTLLKN-----------------ADVKLEMYVEYFRTIGLAFIIPIIFLYAFQQVASLAYNYWLSLWADDPVI-------------------------NGTQVNTDLKLGVYGALGFAQGIAIFGTTVAISLGGIIASRQLHLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLKIMLGYVFKLLEVCIIVLMATPFAGVIILPLTLLYAFIQSFYVATSCQLRRLESVSRSPIYTHFNETVQGASVIRAFGEQPRFILQANCRVDLNQTSYFPRFVASRWLAVNLEFLGNLLVLAAAILSVMGRATLSPGTVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVKEYAETAKEAPWTFEDSPL----PSDWPRSGSIGFQAYGLQYRKGLDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLKTFVSDLPDKLNHECSEGGENLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGNITEIDSPSNLISQHGQFYRMCR 1436 HSP 2 Score: 63.1586 bits (152), Expect = 2.866e-9 Identity = 59/239 (24.69%), Postives = 110/239 (46.03%), Query Frame = 2
Query: 1823 SFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKG-------------SMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN-----GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSF 2485
+R + LK I++S+N+ E VGIVG+ +GK+SL I + G + I G ++ +PQ+P + S + N+ +Y + + + + L ++ D+LN G + + S GQRQ I LARA+ +K++I +LD+ +A+D + + + I + T L + +N + ++I +D G+I SN+ + F ++ E
Sbjct: 1209 GLQYRKGLDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLK-TFVSDLPDKLNHECSEGGENL--SLGQRQLICLARALLRKTKILVLDEATAAVD-LKTDNLIQSTIRTQ--FEDCTVLTIAHRLNTIMDYTRVIVMDR-GNITEIDSPSNLISQHGQFYRMCREAGL 1440
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc6b.2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-110208-2]) HSP 1 Score: 687.952 bits (1774), Expect = 0.000e+0 Identity = 440/1340 (32.84%), Postives = 713/1340 (53.21%), Query Frame = 2
Query: 578 NNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTF-----DVHYQCVADVNTMNFKR--KLTSTLKSKNNYHTKS-----------RRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQ------DIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESE----FNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
NPCP E +S S++LF W R + +++ +K+E + D + + D+ K+ KL S N T R+ E + + L + L +F + +V FS P +L LL ++ + PL+ G+ A S + L S+ + + T ++V++A+ VY KS+ IN+ A+ T T EI+NL+S DT K+V + Y + +P EI L FL+ +G G+ ++ FPLN Q +M+ KD+RIK M E+L+ +K++K Y+WE F + + REKE+N ++ + V +++ + + M YV I +V+ A+ FVS+ L+N+L++P++ LP ++ M VSLKR+ FL +++ K S Q +I SV+ I NG+FSW DS P L+RIN+ + +G LV +VG + SGK+SLL+A++GEM G ++I GS+ YVPQ WI+ + KDNI+ + ++ Y+ V+ C L DL A + G + SGGQ+QR++LARAVY+ S+IYLLDDPLSA+DA V Q +FEKVI NG L N TR+ VT ++FL D I+ + +G IK G + + + F ++ K+FS +E ES R S I + + ++ + + + + R ++ V + Y +YF G + IF + + + +YWL DP I + + +YG +GF Q I + SLG AS+ +H +LN VL S + +F + S +LN FSK+ID ID +IP+ L ++ +F+++ ++L P ++I+P+ LLY I FY+ ++CQ + L S SPI+ FNET+QG VIRA ++ F + ++ N + + V + WL++ L+FLGN+LV + I+++ R L+P VGL +S+S+ + +L+W++ + D+E N +++ER+ + E F D S+WPR G I F+ + L+Y + + L I+L + EK+GIVGRTG+GK+SL +F+++E G + ID I+I +I + ++R IT+ PQ+ +FSG++R N+DPF+ D + ++L L+HL ++ + L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD +TD LI TI+ +F + T+L IAHR + + D ++IVMDRG I E S +I+ ++ C+
Sbjct: 203 KNPCPVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICDLEKEWAKQWAKLQQKKSSLNEAQTLGFKLSSCVKQLFRKLFKEQCTGFVLFRTLAKIFSPYFLTGTLFLVIQDALMFSIPQVLSLLLGYVRDEDAPLWKGYLFAFSLFLLSCLQSLFNHQYMYTCLTVGMRVKTAVMGLVYRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQHLGPSTLAGITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRERVLGYREKELNALKKSQILYSVSIASFNSSTLLIAFAMFGVYVLIDDKHVLDAQKIFVSMALINILKAPLSQLPIAMSTTMQVVVSLKRLGTFLDQDELK--LDSVQRVPYNPNIESVV-INNGTFSWSKDSTPCLRRINVKVQRGSLVAVVGHVGSGKSSLLSAMLGEMEKKSGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLEILPARDATEIGEKGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGSLKNKTRVLVTHGLSFLPQADLILVM-ADGEIKEMGSYAELLSRKNAFAEL---KAFS--VSERKESATLKG-----TRKSVSFLSI--KDFSTDLIRGDLGSASIQTMEAISDPKLNQDRDEVGRLTQADKAHTGRVKLEMYVEYFRTIGLAFIIPIIFLYAFQQVASLAYNYWLSLWADDPVI-------------------------NGTQVNTDLKLGVYGALGFAQGIAIFGTTVAISLGGIIASRQLHLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLKIMLGYVFKLLEVCIIVLMATPFAGVIILPLTLLYAFIQSFYVATSCQLRRLESVSRSPIYTHFNETVQGASVIRAFGEQPRFILQANCRVDLNQTSYFPRFVASRWLAVNLEFLGNLLVLAAAILSVMGRATLSPGTVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVKEYAETAKEAPWTFEDSPL----PSDWPRSGSIGFQAYGLQYRKGLDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLKTFVSDLPDKLNHECSEGGENLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGNITEIDSPSNLISQHGQFYRMCR 1497 HSP 2 Score: 62.3882 bits (150), Expect = 5.398e-9 Identity = 59/239 (24.69%), Postives = 110/239 (46.03%), Query Frame = 2
Query: 1823 SFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKG-------------SMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN-----GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSF 2485
+R + LK I++S+N+ E VGIVG+ +GK+SL I + G + I G ++ +PQ+P + S + N+ +Y + + + + L ++ D+LN G + + S GQRQ I LARA+ +K++I +LD+ +A+D + + + I + T L + +N + ++I +D G+I SN+ + F ++ E
Sbjct: 1270 GLQYRKGLDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLK-TFVSDLPDKLNHECSEGGENL--SLGQRQLICLARALLRKTKILVLDEATAAVD-LKTDNLIQSTIRTQ--FEDCTVLTIAHRLNTIMDYTRVIVMDR-GNITEIDSPSNLISQHGQFYRMCREAGL 1501
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Match: abcc6b.2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 6b, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-110208-2]) HSP 1 Score: 685.641 bits (1768), Expect = 0.000e+0 Identity = 436/1329 (32.81%), Postives = 710/1329 (53.42%), Query Frame = 2
Query: 578 NNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIR---SVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFD----------TEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESE----FNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
NPCP E +S S++LF W R + +++ +K+E + + + ++ K+ T + R+ E + + L + L +F + +V FS P +L LL ++ + PL+ G+ A S + L S+ + + T ++V++A+ VY KS+ IN+ A+ T T EI+NL+S DT K+V + Y + +P EI L FL+ +G G+ ++ FPLN Q +M+ KD+RIK M E+L+ +K++K Y+WE F + + REKE+N ++ + V +++ + + M YV I +V+ A+ FVS+ L+N+L++P++ LP ++ M VSLKR+ FL +++ K S Q + S + I NG+FSW DS P L+RIN+ + +G LV +VG + SGK+SLL+A++GEM G ++I GS+ YVPQ WI+ + KDNI+ + ++ Y+ V+ C L DL A + G + SGGQ+QR++LARAVY+ S+IYLLDDPLSA+DA V Q +FEKVI NG L N TR+ VT ++FL D I+ + +G IK G + + + F ++K +FS +E ES+ + + R S I S + N F+ + + ++D D V + Y +YF G + IF + + + +YWL DP I + + +YG +GF Q I + SLG AS+ +H +LN VL S + +F + S +LN FSK+ID ID +IP+ L ++ +F+++ ++L P ++I+P+ LLY I FY+ ++CQ + L S SPI+ FNET+QG VIRA ++ F + ++ N + + V + WL++ L+FLGN+LV + I+++ R L+P VGL +S+S+ + +L+W++ + D+E N +++ER+ + E F D S+WPR G I F+ + L+Y + + L I+L + EK+GIVGRTG+GK+SL +F+++E G + ID I+I +I + ++R IT+ PQ+ +FSG++R N+DPF+ D + ++L L+HL ++ + L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD +TD LI TI+ +F + T+L IAHR + + D ++IVMDRG I E S +I+ ++ C+
Sbjct: 172 KNPCPVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSE--------KIIYTCYLSSCVKQLFRKLFKEQCTGFVLFRTLAKIFSPYFLTGTLFLVIQDALMFSIPQVLSLLLGYVRDEDAPLWKGYLFAFSLFLLSCLQSLFNHQYMYTCLTVGMRVKTAVMGLVYRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAPIEIALCLFFLWQHLGPSTLAGITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIKILKFYAWEKAFRERVLGYREKELNALKKSQILYSVSIASFNSSTLLIAFAMFGVYVLIDDKHVLDAQKIFVSMALINILKAPLSQLPIAMSTTMQVVVSLKRLGTFLDQDELK--LDSVQRVPYNPSDVVINNGTFSWSKDSTPCLRRINVKVQRGSLVAVVGHVGSGKSSLLSAMLGEMEKKSGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKDSLYQKVLEACALLPDLEILPARDATEIGEKGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVDAHVGQHIFEKVIGPNGSLKNKTRVLVTHGLSFLPQADLILVM-ADGEIKEMGSYAELLSRKNAFAELK---AFS--VSERKESM----HLVLGTRKSVSFLSIKDFSTDLISFK-NATFTFVEKGDLGSASIQTMEAISDPKLNQDRDEVGRLTQADKAHTGRVKLEMYVEYFRTIGLAFIIPIIFLYAFQQVASLAYNYWLSLWADDPVI-------------------------NGTQVNTDLKLGVYGALGFAQGIAIFGTTVAISLGGIIASRQLHLDLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIPHGLKIMLGYVFKLLEVCIIVLMATPFAGVIILPLTLLYAFIQSFYVATSCQLRRLESVSRSPIYTHFNETVQGASVIRAFGEQPRFILQANCRVDLNQTSYFPRFVASRWLAVNLEFLGNLLVLAAAILSVMGRATLSPGTVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVKEYAETAKEAPWTFEDSPL----PSDWPRSGSIGFQAYGLQYRKGLDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLKTFVSDLPDKLNHECSEGGENLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGNITEIDSPSNLISQHGQFYRMCR 1450 HSP 2 Score: 62.3882 bits (150), Expect = 5.141e-9 Identity = 59/239 (24.69%), Postives = 110/239 (46.03%), Query Frame = 2
Query: 1823 SFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKG-------------SMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN-----GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSF 2485
+R + LK I++S+N+ E VGIVG+ +GK+SL I + G + I G ++ +PQ+P + S + N+ +Y + + + + L ++ D+LN G + + S GQRQ I LARA+ +K++I +LD+ +A+D + + + I + T L + +N + ++I +D G+I SN+ + F ++ E
Sbjct: 1223 GLQYRKGLDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIAEIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLK-TFVSDLPDKLNHECSEGGENL--SLGQRQLICLARALLRKTKILVLDEATAAVD-LKTDNLIQSTIRTQ--FEDCTVLTIAHRLNTIMDYTRVIVMDR-GNITEIDSPSNLISQHGQFYRMCREAGL 1454
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 715.687 bits (1846), Expect = 0.000e+0 Identity = 457/1355 (33.73%), Postives = 733/1355 (54.10%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQC----VADVNTMNFKR-------------------KLTSTLKSKNNYHTKSRRPINEHSSVWW---LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLI--ENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLR---TNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENG--SIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMN---RNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRA-SKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
N ++ NPCPE +S S+I F W+ R + F+ ++++ + ++ + V V + N+++ K T L SK + ++ I + + L KAL+ FG IS FH + FS P +L+ L+KF+ + P + G+ L ++ + FH+ T +++++A+ VY K++ INN A+ T T EI+NLMS D + + Y ++ S+P ++IL F L+ +G LA I V+VL+ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+ E+ +++ + + V W P V L+ YV I V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL E + ++ Q I +K+ +FSW + P LK INISI +G LV +VG++ GK+SLL+A++GEM DG V++KGS+ YV Q WI+ S KDN++ ++ E+ YK VI C L DL T E+ G + SGGQ+QR++LARAVY ++IYLLDDPLSA+DA V + +F+KVI G+L N TR+ VT +++L +D II + + + Y D+ +F++ + + E S S + N RN + + L AS ++K N ++S +E + V +++Y A G F SIF F + + S+YWL T D + + +YG +GF Q I + SLG AS+ +H +L+ VL+ + +F ++ S ++N FSK+ID ID+ IP + + +F V+ + +IL P+ ++I P+GL+YF + +FY+ ++ Q + L S SP++ FNETL G VIRA +QK+ Q FK +++N + Y V N WL++RL+F+GN +V + + A+ R L+P LVGL++SY++ + LNW++ +LETN +A+ER+ + ++ E P++ WP GKIEF+ + L+Y ED L NIN+ I+ GEK+GIVGRTG+GK+SL LF++ E G ++ID ++ I + D+R +T+ PQ+ +FSGT+R N+DPF+ D + +L L+HL ++ ++ L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ F + T++ IAHR + + D K+IV+D+G+++EF S ++ +F+ K
Sbjct: 158 NCYRQSCNPCPESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAPDWHGYLYTFLLFFCACLQTLILHKYFHICFVTGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLL--VPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIREPQKTEGSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEI-GEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVDGKITEVGSYQDLLMQDGAFAEFLRTYANAE-QNKDQEEAPSPVPSEEKRLENGILRNERNLQRQLSASSETKSLNQNKTGDL------------NSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTDDKVV-------------------------NGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFK-VDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFFNMAK 1470
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 711.449 bits (1835), Expect = 0.000e+0 Identity = 456/1353 (33.70%), Postives = 732/1353 (54.10%), Query Frame = 2
Query: 569 IENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQC----VADVNTMNFKR-------------------KLTSTLKSKNNYHTKSRRPINEHSSVWW---LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLI--ENKTKNYFSSCQ-DIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLR---TNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENG--SIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMN---RNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRA-SKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + NPCPE +S S+I F W+ R + F+ ++++ + ++ + V V + N+++ K T L SK + ++ I + + L KAL+ FG IS FH + FS P +L+ L+KF+ + P + G+ L ++ + FH+ T +++++A+ VY K++ INN A+ T T EI+NLMS D + + Y ++ S+P ++IL F L+ +G LA I V+VL+ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+ E+ +++ + + V W P V L+ YV I V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL E + ++ Q I +K+ +FSW + P LK INISI +G LV +VG++ GK+SLL+A++GEM DG V++KGS+ YV Q WI+ S KDN++ ++ E+ YK VI C L DL T E+ G + SGGQ+QR++LARAVY ++IYLLDDPLSA+DA V + +F+KVI G+L N TR+ VT +++L +D II + + + Y D+ +F++ + + E S S + N RN + + L AS ++K N ++S +E + V +++Y A G F SIF F + + S+YWL T D + + +YG +GF Q I + SLG AS+ +H +L+ VL+ + +F ++ S ++N FSK+ID ID+ IP + + +F V+ + +IL P+ ++I P+GL+YF + +FY+ ++ Q + L S SP++ FNETL G VIRA +QK+ Q FK +++N + Y V N WL++RL+F+GN +V + + A+ R L+P LVGL++SY++ + LNW++ +LETN +A+ER+ + ++ E P++ WP GKIEF+ + L+Y ED L NIN+ I+ GEK+GIVGRTG+GK+SL LF++ E G ++ID ++ I + D+R +T+ PQ+ +FSGT+R N+DPF+ D + +L L+HL ++ ++ L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ F + T++ IAHR + + D K+IV+D+G+++EF S ++ +F+ K
Sbjct: 186 VNDPNPCPESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAPDWHGYLYTFLLFFCACLQTLILHKYFHICFVTGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLL--VPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIREPQKSSEGSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEI-GEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVMVDGKITEVGSYQDLLMQDGAFAEFLRTYANAE-QNKDQEEAPSPVPSEEKRLENGILRNERNLQRQLSASSETKSLNQNKTGDL------------NSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTDDKVV-------------------------NGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFK-VDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFFNMAK 1496
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 706.827 bits (1823), Expect = 0.000e+0 Identity = 453/1349 (33.58%), Postives = 735/1349 (54.48%), Query Frame = 2
Query: 569 IENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQC----VADVNTMNFKR-------------------KLTSTLKSKNNYHTKSRRPINEHSSVWW---LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLI--ENKTKNYFSSCQ-DIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLR---TNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIH-KILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRA-SKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + NPCPE +S S+I F W+ R + F+ ++++ + ++ + V V + N+++ K T L SK + ++ I + + L KAL+ FG IS FH + FS P +L+ L+KF+ + P + G+ L ++ + FH+ T +++++A+ VY K++ INN A+ T T EI+NLMS D + + Y ++ S+P ++IL F L+ +G LA I V+VL+ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+ E+ +++ + + V W P V L+ YV I V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL E + ++ Q I +K+ +FSW + P LK INISI +G LV +VG++ GK+SLL+A++GEM DG V++KGS+ YV Q WI+ S KDN++ ++ E+ YK VI C L DL T E+ G + SGGQ+QR++LARAVY ++IYLLDDPLSA+DA V + +F+KVI G+L N TR+ VT +++L +D II + +G I G ++ M+ + F +A ++ N+ R++ H + Q++ + +N ++ +S+ + + D + V +++Y A G F SIF F + + S+YWL T D + + +YG +GF Q I + SLG AS+ +H +L+ VL+ + +F ++ S ++N FSK+ID ID+ IP + + +F V+ + +IL P+ ++I P+GL+YF + +FY+ ++ Q + L S SP++ FNETL G VIRA +QK+ Q FK +++N + Y V N WL++RL+F+GN +V + + A+ R L+P LVGL++SY++ + LNW++ +LETN +A+ER+ + ++ E P++ WP GKIEF+ + L+Y ED L NIN+ I+ GEK+GIVGRTG+GK+SL LF++ E G ++ID ++ I + D+R +T+ PQ+ +FSGT+R N+DPF+ D + +L L+HL ++ ++ L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ F + T++ IAHR + + D K+IV+D+G+++EF S ++ +F+ K
Sbjct: 196 VNDPNPCPESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAPDWHGYLYTFLLFFCACLQTLILHKYFHICFVTGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLL--VPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIREPQKSSEGSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEI-GEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVM-VDGKITEVGSYQDL------LMQDGAFAEFLRTYANAEQN--KDQEGKPSNQEESRLYLNRFHIHFLFNFRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEAD-KAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTDDKVV-------------------------NGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFK-VDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFFNMAK 1505
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 702.975 bits (1813), Expect = 0.000e+0 Identity = 456/1360 (33.53%), Postives = 740/1360 (54.41%), Query Frame = 2
Query: 569 IENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQC----VADVNTMNFKR-------------------KLTSTLKSKNNYHTKSRRPINEHSSVWW---LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLI--ENKTKNYFSSCQ-DIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLR---TNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIH----KILHASIKSKY--HQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDF------DTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRA-SKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + NPCPE +S S+I F W+ R + F+ ++++ + ++ + V V + N+++ K T L SK + ++ I + + L KAL+ FG IS FH + FS P +L+ L+KF+ + P + G+ L ++ + FH+ T +++++A+ VY K++ INN A+ T T EI+NLMS D + + Y ++ S+P ++IL F L+ +G LA I V+VL+ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+ E+ +++ + + V W P V L+ YV I V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL E + ++ Q I +K+ +FSW + P LK INISI +G LV +VG++ GK+SLL+A++GEM DG V++KGS+ YV Q WI+ S KDN++ ++ E+ YK VI C L DL T E+ G + SGGQ+QR++LARAVY ++IYLLDDPLSA+DA V + +F+KVI G+L N TR+ VT +++L +D II + +G I G ++ M+ + F +A ++ N+ R++ +L ++ Y N + L ++ + N + + L+ S+ +D+ + V +++Y A G F SIF F + + S+YWL T D + + +YG +GF Q I + SLG AS+ +H +L+ VL+ + +F ++ S ++N FSK+ID ID+ IP + + +F V+ + +IL P+ ++I P+GL+YF + +FY+ ++ Q + L S SP++ FNETL G VIRA +QK+ Q FK +++N + Y V N WL++RL+F+GN +V + + A+ R L+P LVGL++SY++ + LNW++ +LETN +A+ER+ + ++ E P++ WP GKIEF+ + L+Y ED L NIN+ I+ GEK+GIVGRTG+GK+SL LF++ E G ++ID ++ I + D+R +T+ PQ+ +FSGT+R N+DPF+ D + +L L+HL ++ ++ L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ F + T++ IAHR + + D K+IV+D+G+++EF S ++ +F+ K
Sbjct: 174 VNDPNPCPESSASFLSQITFWWISRMMVQGFKRPLEAKDLWSLNKEDKSLEVVPVLSKNWEKEYNKAKAKKVPLKMVYSPKKQTKKLNSKEDVREEAEALIVKPAPKELEPSLLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAPDWHGYLYTFLLFFCACLQTLILHKYFHICFVTGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLL--VPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIREPQKSSEGSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEI-GEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVM-VDGKITEVGSYQDL------LMQDGAFAEFLRTYANAEQN--KDQEGKPSNQEESRLYLNALYLLCVTVYYVYFPQAYNTGPRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTDDKVV-------------------------NGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFK-VDENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFFNMAK 1495
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Match: ABCC1 (ATP binding cassette subfamily C member 1 [Source:HGNC Symbol;Acc:HGNC:51]) HSP 1 Score: 698.738 bits (1802), Expect = 0.000e+0 Identity = 436/1244 (35.05%), Postives = 697/1244 (56.03%), Query Frame = 2
Query: 827 LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLI--ENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLR---TNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIH-KILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKS--------VSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRA-SKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
L KAL+ FG IS FH + FS P +L+ L+KF+ + P + G+ L ++ + FH+ T +++++A+ VY K++ INN A+ T T EI+NLMS D + + Y ++ S+P ++IL F L+ +G LA I V+VL+ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+ E+ +++ + + V W P V L+ YV I V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL E + ++ Q I +K+ +FSW + P LK INISI +G LV +VG++ GK+SLL+A++GEM DG V++KGS+ YV Q WI+ S KDN++ ++ E+ YK VI C L DL T E+ G + SGGQ+QR++LARAVY ++IYLLDDPLSA+DA V + +F+KVI G+L N TR+ VT +++L +D II + +G I G ++ M+ + F +A ++ N+ R++ L+ +++H I+ F ++ S K+ + +++ + SE D ++ V +++Y A G F SIF F + + S+YWL T D + + +YG +GF Q I + SLG AS+ +H +L+ VL+ + +F ++ S ++N FSK+ID ID+ IP + + +F V+ + +IL P+ ++I P+GL+YF + +FY+ ++ Q + L S SP++ FNETL G VIRA +QK+ Q FK+ ++N + Y V N WL++RL+F+GN +V + + A+ R L+P LVGL++SY++ + LNW++ +LETN +A+ER+ + ++ E P++ WP GKIEF+ + L+Y ED L NIN+ I+ GEK+GIVGRTG+GK+SL LF++ E G ++ID ++ I + D+R +T+ PQ+ +FSGT+R N+DPF+ D + +L L+HL ++ ++ L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ F + T++ IAHR + + D K+IV+D+G+++EF S ++ +F+ K
Sbjct: 270 LLKALYKTFGPYFFISCFFKFFHDVLMFSGPQLLQLLIKFVGDKDAPDWHGYLYTFLLFFCACLQTLILHKYFHICFVTGMRLKTAVVGLVYRKALVINNSARRTSTIGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILAFYLLWQNLGPSVLAGIAVMVLL--VPVNAVIAMKTKKYQVVQMKCKDNRIKLMNEILNGIKVLKLYAWELAFKEKVLGIRKDELKVLKKSAYLAAVGTFTWVCAPFLVALSTFAVYVLIDKQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELEPESIIREPQKTEGSINMKDATFSWSRNDLPSLKDINISIPEGSLVAVVGQVGCGKSSLLSALLGEMEKQDGYVAMKGSVGYVSQQAWIQNASLKDNVLFGRESNESMYKKVIEACALLPDLEILPTGDRTEI-GEKGVNLSGGQKQRVSLARAVYCNTDIYLLDDPLSAVDAHVGKHIFDKVIGPKGMLKNKTRILVTHGVSYLPQMDSIIVM-VDGKITEVGSYQDL------LMQDGAFAEFLRTYANAEQN--KDQEGKPSNQEESRLYLNALYLLCVTRFH-IHFLFNFRQLSASSETKSLNQNKTGDLNSSEKDDWKLTEADKAKTGRVKLAVFWEYMKAIGLFLCFLSIFLFMCNHVASLASNYWLSLWTDDKVV-------------------------NGTQQNTTMRLSVYGALGFSQGIAVYGYSTAVSLGGILASRFLHTDLLHNVLRFPMSFFERTPSGNLVNRFSKEIDTIDNTIPQIIKMFMGSLFNVIGACVIILTATPIVAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGSSVIRAFGEQKRFIQISDFKV-DENQRAYYPSIVSNRWLAIRLEFVGNCIVLFASLFAVISRTTLSPGLVGLSVSYALQVTTYLNWLVRMSSELETNIVAVERVKEYADLKQEAAWTVQETAPEATWPHEGKIEFRGYGLRYREDLDLALKNINVTIQGGEKVGIVGRTGAGKSSLTLGLFRINEAAAGEIVIDGCNLAKIGLHDLRFRVTIIPQDPVLFSGTLRMNLDPFDKYTDDDIWTSLELAHLKRFVANLPDRLNHECAEGGENLSIGQRQLVCLARALLRKTKILVLDEATAAVDLETDGLIQSTIRKEFQDCTVITIAHRLNTIMDYTKVIVLDKGQVVEFDSPSNLLQQQGIFFNMAK 1474
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 1 [Source:MGI Symbol;Acc:MGI:102676]) HSP 1 Score: 709.909 bits (1831), Expect = 0.000e+0 Identity = 444/1357 (32.72%), Postives = 732/1357 (53.94%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQC----VADVNTMNFKRKLTSTLKS---------KNNYHTKSRRPINEHSSVWWLT-------------KALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRS----VIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMK-IKSEKSFSDPFAEHTESIFTSN------NNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGF--GQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + + NPCPE +S SRI F W+ + ++ ++S + ++ + V V N+K++ + K K+ K ++ + V L K L+ FG ++S+ H + F+ P IL+ ++ F++ E P + G+ ++ L ++ + FH+ + +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++IL FL+ +G GV V++ PLN++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + + V W P V L+ +V + ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + I+S I +KN +F+W P L I SI +G LV +VG++ GK+SLL+A++ EM ++G V++KGS++YVPQ WI+ S ++NI+ EN YK V+ C L DL + + G + SGGQ+QR++LARAVY S+IYL DDPLSA+DA V + +FEKV+ G+L N TR+ VT I++L +D II + G I G + + F + +++ + A +S+ S N ++ ++ H H S S H + +Q + + + L E + V Y+ Y A G F SIF F + + S+YWL T DP ++N T A N+ + +YG +G G IF + + S+G AS+ +H +L VL+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + +IL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ I LNW++ ++ETN +A+ERL ++ E E + P S WP G++EF+ + L+Y ED L +IN+ IE GEK+GIVGRTG+GK+SL LF++ E G ++ID ++I I + ++R IT+ PQ+ +FSG++R N+DPF+ D + AL L+HL ++ ++ L+ +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IV+D+GE+ E G SE++ ++S K
Sbjct: 199 SETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMS-GGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLS-NSSSHSGDTSQQHSSIAELQKAGAKEETWKLM----EADKAQTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGT------------------------QANRNFRLSVYGALGILQGAAIFG--YSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQRGIFYSMAK 1523
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:MGI Symbol;Acc:MGI:1923658]) HSP 1 Score: 666.766 bits (1719), Expect = 0.000e+0 Identity = 419/1351 (31.01%), Postives = 710/1351 (52.55%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIK-----SESTFDVHYQCVADV------NTMNFKRKLTSTLKSK---NNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSV-----IEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDL--DFDLRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFD-------------------TEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ NPCPE + SR+ F W R ++ ++ S S D ++ V + R T+T + K + RP ++ S +AL F S L++S C + + F P +L L++FIS P P ++GF LA ++ + ++ + +H +L++R+AI +Y K++ I N K T E++NLMS D + + + ++ S+P ++IL FL+ +G A GV V++ PLN ++ YQ ++M++KD RIK M+E+LN +KV+KLY+WE F + + R+ E+ L+R + + IW P V L L YV + + V+ AE FVS+ L N+L+ P+ +LP I+ VSLKR+ FL +N+ C + +++ I I NG+F+W D P L +NI I KG LV +VG + GK+SL++A++GEM L+G VS+KGS++YVPQ WI+ + ++N++ + Y+ + C L D D+ G + SGGQRQR++LARAVY + I+LLDDPLSA+D+ VA+ +F++VI G+LA TR+ VT I+FL D II L G + G S + F + + +H ++ +N ++ ++ H L + + Y +RKQF+ +S ++ +R++ + + + E +V Y+ Y + G +G + + ++ WL ++D + + + +Y +G Q + T +G A++ +H+ +L+ ++S +F + S +ILN FSKDI ID ++ + ++N F +++ VI+ + PLF+++++P+ +LY + +FY+ ++ Q + L S SPIF F+ET+ G VIRA + + F+ +++N K Y N WL + ++F+GN +V + + A+ RN L P LVGL++SY++ + LNWMI DLE+N +A+ER+ ++ ++E WP G +EF+ ++++Y + L N+ + ++ GEK+GIVGRTG+GK+S+ LF+++E G ++ID +++ I + D+R +T+ PQ+ +FSGT+R N+DPF + + +AL LSHL ++ S L F C + G +LSVGQRQL+CLAR +LR S+++VLDEATA++D ETD LI TI+ +F + T+L IAHR + + D ++++V+D+G + EF +I ++ K
Sbjct: 203 DTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQKQQNQASRSQTATAEPKIPGEDAVLLKPRPKSKQPS---FLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELD---PQCVERKTISPGYAITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVL-AGGQVSEMGHYSALLQHDGSFANFLRNYAPDEDQEDHEAALQNANEEVLLLEDTLSTHTDLTDNEPAIYE---VRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICLLYGGQSAAAIGANVWLSAWSNDAE-------------------------EHGQQNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNRAPEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAAGGIFYGMAK 1518
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:MGI Symbol;Acc:MGI:1923658]) HSP 1 Score: 664.07 bits (1712), Expect = 0.000e+0 Identity = 421/1351 (31.16%), Postives = 710/1351 (52.55%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIK-----SESTFDVHYQCVADV------NTMNFKRKLTSTLKSK---NNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSV-----IEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDL--DFDLRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFD-------------------TEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ NPCPE + SR+ F W R ++ ++ S S D ++ V + R T+T + K + RP ++ S +AL F S L++S C + + F P +L L++FIS P P ++GF LA ++ + ++ + +H +L++R+AI +Y K++ I N K T E++NLMS D + + + ++ S+P ++IL FL+ +G A GV V++ PLN ++ YQ ++M++KD RIK M+E+LN +KV+KLY+WE F + + R+ E+ L+R + + IW P V L L YV + + V+ AE FVS+ L N+L+ P+ +LP I+ VSLKR+ FL +N+ C + +++ I I NG+F+W D P L +NI I KG LV +VG + GK+SL++A++GEM L+G VS+KGS++YVPQ WI+ + ++N++ + Y+ + C L D D+ G + SGGQRQR++LARAVY + I+LLDDPLSA+D+ VA+ +F++VI G+LA TR+ VT I+FL D II L G + G S + F + D E E++ +N ++ ++ H L + + Y +RKQF+ +S ++ +R++ + + + E +V Y+ Y + G +G + + ++ WL ++D + + + +Y +G Q + T +G A++ +H+ +L+ ++S +F + S +ILN FSKDI ID ++ + ++N F +++ VI+ + PLF+++++P+ +LY + +FY+ ++ Q + L S SPIF F+ET+ G VIRA + + F+ +++N K Y N WL + ++F+GN +V + + A+ RN L P LVGL++SY++ + LNWMI DLE+N +A+ER+ ++ ++E WP G +EF+ ++++Y + L N+ + ++ GEK+GIVGRTG+GK+S+ LF+++E G ++ID +++ I + D+R +T+ PQ+ +FSGT+R N+DPF + + +AL LSHL ++ S L F C + G +LSVGQRQL+CLAR +LR S+++VLDEATA++D ETD LI TI+ +F + T+L IAHR + + D ++++V+D+G + EF +I ++ K
Sbjct: 203 DTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQKQQNQASRSQTATAEPKIPGEDAVLLKPRPKSKQPS---FLRALVRTFTSSLLMSACFNLIQNLLGFVNPQLLSILIRFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIGVIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGIRQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYVYVDESNVLDAEKAFVSLSLFNILKIPLNMLPQLISGLTQASVSLKRIQDFLNQNELD---PQCVERKTISPGYAITIHNGTFTWAQDLPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVL-AGGQVSEMGHYSALLQHDGSFANFLRNYA-PDEDQEDHEALQNANEEVLLLEDTLSTHTDLTDNEPAIYE---VRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKLSVYWDYAKSMGLCTTLSICLLYGGQSAAAIGANVWLSAWSNDAE-------------------------EHGQQNKTSVRLGVYAALGILQGLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTILMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFSETVTGTSVIRAYGRIQDFKVLSDTKVDNNQKSSYPYIASNRWLGVHVEFVGNCVVLFAALFAVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEYSKTKTEAPWVVESNRAPEGWPTRGMVEFRNYSVRYRPGLELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELSHLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAAGGIFYGMAK 1517
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc2 (ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Source:MGI Symbol;Acc:MGI:1352447]) HSP 1 Score: 629.402 bits (1622), Expect = 0.000e+0 Identity = 423/1377 (30.72%), Postives = 719/1377 (52.21%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTL------------KSKNNYHTKSRRPINEHSSVW------------------------WLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEV-NLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDI---RSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMK-IKSEKSFSDPFAEHT------------------ESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESE---FNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
++ P +S S + F W D + +++ + E +D+ A T FK +T L KS+ + S + S WL KALF F ++ S+ + H I F P +LK+L+ F+ P++ + G+ AI ++ S C F + VR+ I ++VY K++ ++N A+ +T E +NLMS D+ K++ Y ++ SS +I L FL+ E+G LA +G++VL+ P+N + + ++ Q + M+ KDKR+K M E+L+ +K++K ++WE F + ++ R+KE+ NL+R L + ++ I+ T P V + YV + V+ AE F S+ L N+LR P+A+LP I+ + VS+ R+ +L + S+ + + ++ SF+W D E ++ +N+ I G+LV +VG + SGK+SL++A++GEM + G ++IKGS++YVPQ WI+ + KDNI+ +Y E Y+ VI C L DL ++ G + SGGQ+ R++LARA YQ ++IY+LDDPLSA+D V + +F KV+ NG+L+ TR+ VT I+FL +D+I+ L + G+I G S++ + F K K+ S P E T E I + M R + + +S ++ K L + + + ++F E V + Y KY A G L + + + + + ++ WL TSD + + + + + ++G +G Q IF L NASK +H +L +L++ + +F + + +I+N F+ DI +D +P L + C F ++++ +I P+F+++I+P+ +LY + FY+ ++ Q + L + SPI+ F+ET+ G PVIRA + ++ F K ++ N K ++ N WL++RL+ +GN++VF S ++ + Y+N LT VG +S +++I LNW++ ++ETN +A+ER++ + +++E DK+ P ++WP+ G+I+F + ++Y + L I I+ EK+G+VGRTG+GK+SL LF+++E GG ++ID IDI I + D+R +T+ PQ+ +FSG +R N+DPFN D + +AL L+HL ++ + L + + G +LS+GQRQLLCL R +LR SKI+VLDEATA+VD ETD LI TI++ F T++ IAHR + D DKI+V+D G+I+E+G E+++N ++ K
Sbjct: 188 DSTHAPSATASFLSSVTFSWYDSTVLKGYKHPLTIEDVWDIEENLKAKSLTSKFKTIMTKDLQKARQALQRRLKKSQQSPEGTSHGLTKKQSQSQDVLVLEDSKKKKKKSEATKDFPKSWLVKALFKTFYVVILKSFILKLAHDILLFLNPQLLKFLIGFVKDPDSYPWVGYIYAILMFSVTLIQSFFLQCYFQFCFVLGMTVRTTIIASVYKKALTLSNLARRQYTIGETVNLMSVDSQKLMDVTNYIHLLWSSVLQIALSIFFLWRELGPSILAGVGLMVLL--VPVNGVLATKIRKIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFKEQVNSIRKKELRNLLRFSQLQTILIFILHLT-PTLVSVITFSVYVLVDSQNVLNAEKAFTSITLFNILRFPLAMLPMVISSVIQASVSVDRLEQYLGSDDLD--LSAIRHVCHFDKAVQFSEASFTWDRDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLISAMLGEMENVHGHITIKGSIAYVPQQAWIQNGTIKDNILFGSEYDEKKYQRVIEACALLPDLEMLPGGDMAEIGEKGINLSGGQKHRVSLARATYQDADIYILDDPLSAVDTHVGKHIFNKVVGPNGLLSGKTRILVTHGIHFLPQVDEIVVLGK-GTILEKGSYSDLMDKKGVFAKNWKTFMKHSGPEGEATVDNDSEEEDGDCGLIPTVEEIPDDAASLTMRRENSLRRTLSRSSRSGSRRGKSL-KSSLKIKSVNALNKKEEVVKGQKLIKKEF-VETGKVKFSIYLKYLQAVGWWSLLFIVIFYVLNYVAFIGTNLWLSAWTSDSE---------------------KQNGTDNSPSQRDMRIGVFGALGIAQGIFLLSSSLWSIYACRNASKTLHRQLLTNILRAPMSFFDTTPTGRIVNRFAGDISTVDDTLPQTLRSWLLCFFGIVSTLVMICMATPIFIIIIIPLSILYVSVQVFYVATSRQLRRLDSVTKSPIYSHFSETVSGLPVIRAFEHQQRFLANSEKQIDTNQKCVFSWITSNRWLAIRLELVGNLIVFCSALLLVIYKNSLTGDTVGFVLSNALNITQTLNWLVRMTSEVETNIVAVERINEYINVDNEAPWVTDKK----PPADWPKKGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRNEFSQCTVITIAHRLHTIMDSDKIMVLDSGKIVEYGSPEELLSNMGPFYLMAK 1531 HSP 2 Score: 65.855 bits (159), Expect = 4.702e-10 Identity = 65/259 (25.10%), Postives = 117/259 (45.17%), Query Frame = 2
Query: 1796 RSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAV----------------SIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN----GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTE 2512
+ I+ N +R + + +LK I +I E VG+VG+ +GK+SL N + IL+ A ++G ++ +PQ+P + + + N+ KY + + + + L + Q L+ G D + S GQRQ + L RAV +KS+I +LD+ +A+D + + + I N + T + + ++ + DKI+ LD +G I YG + ++ F + E HTE
Sbjct: 1295 KGEIQFNNYQVRYRPELDLVLKGITCNIKSTEKVGVVGRTGAGKSSLTNCLFR---ILESAGGQIIIDGIDIASIGLHDLRGRLTIIPQDPILFSGNLRMNLDPFNKYSDEEIWRALELAHLKSFVAGLQLGLLHEVTEGGDNL--SIGQRQLLCLGRAVLRKSKILVLDEATAAVD-LETDSLIQTTIRNE--FSQCTVITIAHRLHTIMDSDKIMVLD-SGKIVEYGSPEELLSNMGPFYLMAKEAGIES--VNHTE 1542
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Match: Abcc6 (ATP-binding cassette, sub-family C (CFTR/MRP), member 6 [Source:MGI Symbol;Acc:MGI:1351634]) HSP 1 Score: 504.982 bits (1299), Expect = 1.922e-152 Identity = 362/1328 (27.26%), Postives = 651/1328 (49.02%), Query Frame = 2
Query: 581 NPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNY--HTKSRRPINE------HSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYS---WIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFL-IENKTKNYFSSCQDIRSV---IEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI--SNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHK---ILHASIKSK-YHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYF 4492
NPCPE +S PS+ +F W ++ ++ + + + + + ++ +R+ + + H+ P E S L +A++ VF S ++ ++V F F+ P +L L+F+ + + G+ LA+ L ++ + + +++R+AI VY K + +++ ++ + +++NL+S D ++ +I Y W++ I + F +L+ +G A V V + PLN +Q E+M K R + + +L ++ IK + WE F + + R +E++ ++ +L V + + V L + + + + + AE FV++ +L++L A LP+ + + VS R++ FL +E N + RS I + NG+F+W +S P L IN+++ +G L+ +VG + +GK+SLL+A++GE+ ++G+VSI+GS++YVPQ W++ S +N+ ++ + V+ C L D+ + A G M SGGQ+QR++LARAVY+K+ IYLLDDPL+ALDA V+Q+VF++VI +G+L TTR+ VT ++ L D+I+ L NG+I G ++ N A+ + + + A ++ + R +CR + A +K + ++ + + + +E+ V Y Y A G+ ++F F + YWL DP + HA + ++GL+G Q I LG A AS + +L V +S + +F ++ +LN FSK+ D +D IP+ L ++ F ++ + PL ++ I+P+ +LY Y+ ++CQ + L S + ET QG V+RA + + F + L+++N + + + V + WL+ L+ LGN LVF + A+ + L+ LVG ++S ++ + L W++ + DLE + +A+ER+ ++ + E + WP G+IEF+ F L++ + + ++L I GEK+GIVGRTG+GK+SL L +L E G++ ID + I + + +R IT+ PQ+ +F G++R N+D D + AL L ++ S+ G L ++C G LSVGQ+QLLCLAR +LR ++I++LDEATASVD T+ + ++ F T+L+IAHR + D +++VMD G++ E G ++++ G F
Sbjct: 207 NPCPEAEASFPSKAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWRRSCNGLPGHKGHSSVGAPETEAFLQPERSQRGPLLRAIWRVFRSTFLLGTLSLVISDAFRFAVPKLLSLFLEFMGDRNSSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVYRKVLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLF---LWIFVCFVYLWQLLGPSALTAVAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQELSALKTSTLLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQAFLPFSVHCIVQARVSFDRLAAFLCLEEVDPNGMIASNSRRSSKDRISVHNGTFAWSQESPPCLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVCFRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLSLARAVYKKAAIYLLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVTHTLHVLPQADRILVL-ANGTIAEMGSYQDLLQRNGALVGLLDGARQPAGTHDAATSDDLGGFPGG---GRPTCRPDRPRPTEAAPVKGRSTSEVQMEASL-------------DDPEATGLTAEEDSVRYGRVKTTIYLSYLRAVGTPLCTYTLFLFLCQQVASFSQGYWLSLWADDP-----------------------VVDGRQMHAALRGW--VFGLLGCLQAIGLFASMAAVFLGGARASGLLFRSLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIPDKLRSLLTYAFGLLEVGLAVTMATPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTAQHDALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTCAAQPLWPCGGQIEFRDFGLRHRPELPLAVQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIWIDGVPITHVGLHTLRSRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAFVTSLPGQLQYECAGQGDDLSVGQKQLLCLARALLRKTQILILDEATASVDPGTEMQMQAALERWFTQCTVLLIAHRLRSVMDCARVLVMDEGQVAESGSPAQLLAQ-KGLF 1488
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q5F364|MRP1_CHICK (Multidrug resistance-associated protein 1 OS=Gallus gallus OX=9031 GN=ABCC1 PE=2 SV=1) HSP 1 Score: 712.605 bits (1838), Expect = 0.000e+0 Identity = 452/1358 (33.28%), Postives = 730/1358 (53.76%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTF-----DVHYQCVADVNTMNFKRKLTSTLKSKNN--YHTKSR-------------------RPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDL-------RTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIH----KILHASIK--SKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + + PCPE +S SRI F W+ + + ++++ + D + V + N+ ++ T + N Y +K + +P ++ SS L+K L+ FG ++S+ H + F+ P ILK L+ F++ P + G+ + L ++ + FH+ T +++++AI +Y K++ I N A+ T T EI+NLMS D + + Y ++ S+P ++IL L+ +G GV V++ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+KE+ +++ + + + W P V L+ YV + N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + I +KN +FSW P L IN ++ +G L+ +VG++ GK+SLL+A++GEM +G V +KGS++YVPQ WI+ + +DNII ++ E+ YK VI C L DL RT ++ GV+ SGGQ+QR++LARAVY ++ YL DDPLSA+DA V + +FEKVI GIL N TR+ VT +N+L +D I+ + + G I G + F + + ++ E +++ S N ++ K++H + S Y + + Q +S + S +E + V Y++Y A G F S+F F I + S+YWL T DP + + T Y N + +YG +G Q I + + S+G AS+ +H +L+ VL+S + +F ++ S +++ FSK+ID IDS IP + + F V+ + +IL P+ ++I P+GL+Y ++ +FY+ ++ Q + L S SP++ FNETL G VIRA +++K F + +++N K Y V N WL++RL+F+GN +V + + A+ RNKL+P L+GL++SYS+ I LNW++ DLETN +A+ER+ + ME E P S WP+ GK+EF+ F L+Y ED L NIN+ I GEK+GIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + ++L L+HL ++ S+ L+ +C + G +LSVGQRQL+CLAR +LR SKI+VLDEATA+VD ETD LI TIK +F T+L IAHR + + D +++V+DRGE++E ++ ++S K
Sbjct: 199 SEAVNDPKPCPEFSASFLSRITFWWITGLMIQGHRRPLEAKDLWSLNKEDTSEEIVPGL-AKNWAKEWAKTKRQPLNMLYSSKKQQKSSDSNGEVMEEAEALIIKP-SQRSSEASLSKVLYKTFGPYFLMSFLFKAAHDLLMFTGPEILKLLINFVNNKSAPNWQGYFYTGLLFVCACLQTLILHQYFHICFVTGMRLKTAIVGVIYRKALVITNSARKTSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWRNLGPSVLAGVAVMILLVPINAVMAMKTKTYQVAQMKSKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELKVLKKSAYLAAMGTFTWVCAPFLVALSTFAVYVKVNKNNILDAQKAFVSLALFNILRFPLNILPMVISSIVEASVSLKRLRVFLSHEELDPDSIIRGPITNAEGSIVVKNATFSWSKTDPPSLNSINFTVPEGSLIAVVGQVGCGKSSLLSALLGEMDKKEGYVVVKGSIAYVPQQAWIQNATLEDNIIFGREMNESRYKRVIEACALLPDLEILPMGDRTEIGEK--GVN---LSGGQKQRVSLARAVYCNADTYLFDDPLSAVDAHVGKHIFEKVIGPKGILKNKTRVLVTHAVNYLPQMDTILVMTD-GEISEMGSYQELLKQDGAFAEFLRTYANAEQSMESSDASSPSGKEGKPVENGVLVNDATGKLMHRQLSNSSTYSRETGKSQH---QSSTAELQKPLAEKNSWKLTEADTAKTGRVKATVYWEYMKAIGLYISFLSVFLFMCNHIASLASNYWLSLWTDDPVV--------------------NGTQQY-----TNVRLGVYGALGISQGIAVFGYSMAVSIGGIFASRHLHLDLLHNVLRSPMSFFERTPSGNLVSRFSKEIDTIDSTIPPIIKMFMGSTFNVIGACIIILLATPIAAVVIPPLGLVYLLVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQKRFIKQNDMKVDENQKAYYPSIVANRWLAVRLEFVGNCIVLFAALFAVIARNKLSPGLIGLSVSYSLQITAYLNWLVRMTSDLETNIVAVERVKEYAEMEKEAEWSIEETAPASTWPQEGKVEFRGFGLRYREDLDLVLKNINITINGGEKVGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGINIAKIGLHDLRFKITIIPQDPILFSGSLRMNLDPFDQHSDEDIWRSLELAHLKNFVSSLPDKLNHECSEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDNLIQSTIKSQFEECTVLTIAHRLNTIMDYTRVLVLDRGEVVECDSPDNLLQAKGLFYSMAK 1520
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|O35379|MRP1_MOUSE (Multidrug resistance-associated protein 1 OS=Mus musculus OX=10090 GN=Abcc1 PE=1 SV=1) HSP 1 Score: 709.909 bits (1831), Expect = 0.000e+0 Identity = 444/1357 (32.72%), Postives = 732/1357 (53.94%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQC----VADVNTMNFKRKLTSTLKS---------KNNYHTKSRRPINEHSSVWWLT-------------KALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRS----VIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMK-IKSEKSFSDPFAEHTESIFTSN------NNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGF--GQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + + NPCPE +S SRI F W+ + ++ ++S + ++ + V V N+K++ + K K+ K ++ + V L K L+ FG ++S+ H + F+ P IL+ ++ F++ E P + G+ ++ L ++ + FH+ + +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++IL FL+ +G GV V++ PLN++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + + V W P V L+ +V + ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + I+S I +KN +F+W P L I SI +G LV +VG++ GK+SLL+A++ EM ++G V++KGS++YVPQ WI+ S ++NI+ EN YK V+ C L DL + + G + SGGQ+QR++LARAVY S+IYL DDPLSA+DA V + +FEKV+ G+L N TR+ VT I++L +D II + G I G + + F + +++ + A +S+ S N ++ ++ H H S S H + +Q + + + L E + V Y+ Y A G F SIF F + + S+YWL T DP ++N T A N+ + +YG +G G IF + + S+G AS+ +H +L VL+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + +IL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ I LNW++ ++ETN +A+ERL ++ E E + P S WP G++EF+ + L+Y ED L +IN+ IE GEK+GIVGRTG+GK+SL LF++ E G ++ID ++I I + ++R IT+ PQ+ +FSG++R N+DPF+ D + AL L+HL ++ ++ L+ +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IV+D+GE+ E G SE++ ++S K
Sbjct: 199 SETVHDRNPCPESSASFLSRITFWWITGMMVHGYRQPLESSDLWSLNKEDTSEEVVPVLVNNWKKECDKSRKQPVRIVYAPPKDPSKPKGSSQLDVNEEVEALIVKSPHKDREPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPKILELIINFVNDREAPDWQGYFYTALLFVSACLQTLALHQYFHICFVSGMRIKTAVVGAVYRKALLITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYFLWLSLGPSVLAGVAVMILMVPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMSIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDERNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRSIKSGEGNSITVKNATFTWARGEPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGHPLQENYYKAVMEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNSDIYLFDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMS-GGKISEMGSYQELLDRDGAFAEFLRTYANAEQDLASEDDSVSGSGKESKPVENGMLVTDTVGKHLQRHLS-NSSSHSGDTSQQHSSIAELQKAGAKEETWKLM----EADKAQTGQVQLSVYWNYMKAIGLFITFLSIFLFLCNHVSALASNYWLSLWTDDPPVVNGT------------------------QANRNFRLSVYGALGILQGAAIFG--YSMAVSIGGIFASRRLHLDLLYNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGVNIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEVRECGAPSELLQQRGIFYSMAK 1523
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q8CG09|MRP1_RAT (Multidrug resistance-associated protein 1 OS=Rattus norvegicus OX=10116 GN=Abcc1 PE=1 SV=2) HSP 1 Score: 701.049 bits (1808), Expect = 0.000e+0 Identity = 443/1364 (32.48%), Postives = 729/1364 (53.45%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQC----VADVNTMNFKRKLTSTLKS---------KNNYHTKSRRPINEHSSVWWLT-------------KALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIR-----SVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKII---------------FLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + + NPCPE +S SRI F W+ + ++ +KS + ++ + V V N+K++ + K K+ K ++ + V L K L+ FG ++S+ H + F+ P IL+ ++ F++ E P + G+ ++ L ++ + FH+ T +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++ L FL+ +G GV V++ P N++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + + V W P V L+ +V + ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + I+ + I +KN +F+W D P L I +I G LV +VG++ GK+SLL+A++ EM ++G V++KGS++YVPQ WI+ S ++NI+ + E+ YK V+ C L DL + +L G + SGGQ+QR++LARAVY S+IYLLDDPLSA+DA V + +FEKV+ G+L N TR+ VT I++L +D II LD +G+ + V +N D K+ + ++ + N ++ ++ H S S H + +Q +S S + + E + V Y+ Y A G F SIF F + + S+YWL T D +N T N+ + +YG +G Q + + + S+G AS+ +H +L VL+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + +IL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ I LNW++ ++ETN +A+ERL ++ E E + + P S WP G++EF+ + L+Y ED L +IN+ IE GEK+GIVGRTG+GK+SL LF++ E G ++ID I+I I + ++R IT+ PQ+ +FSG++R N+DPF+ D + AL L+HL ++ ++ L+ +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F +ST+L IAHR + + D ++IV+D+GEI E G SE++ ++S K
Sbjct: 199 SETVRDPNPCPESSASFLSRITFWWITGMMVQGYRQPLKSSDLWSLNKEDTSEEVVPVLVNNWKKECVKSRKQPVRIVYAPPKDPTKPKGSSQLDVNEEVEALIVKSSHKDRDPSLFKVLYKTFGPYFLMSFLYKALHDLMMFAGPEILELIINFVNDREAPDWQGYLYTALLFVSACLQTLALHQYFHICFVTGMRIKTAVVGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVTLALYFLWLNLGPSVLAGVAVMILMVPFNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFQDKVMNIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVFVTVDEKNILDAKKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERWSIKDGGGMNSITVKNATFTWARDEPPTLNGITFAIPDGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVTLKGSVAYVPQQAWIQNDSLRENILFGRPLQEHCYKAVMEACALLPDLEILPSGDLTEIGEKGVNLSGGQKQRVSLARAVYCNSDIYLLDDPLSAVDAHVGKHIFEKVVGPMGLLKNKTRILVTHGISYLPQVDVIIVMSGGKISEMGSYQELLDRDGAFAEF--VRTYANTEQDLASEDDSKNGVSGLGKESKPV----ENGILVTDAVGKPLQRHLS-NSSSHSVVTNQQH----SSTAELQKSGVKEETWKLMEADKAQTGQVKLSVYWNYMKAIGLCISFLSIFLFLCNHVSALASNYWLSLWTDDRPAVNGT------------------------QENRNFRLSVYGALGILQGVAVFGYSMAVSIGGIFASRRLHLDLLQNVLRSPMSFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFSVIGAVIIILLATPIAAVIIPPLGLVYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQITAYLNWLVRMSSEMETNIVAVERLKEYSETEKEASWQIQETAPPSTWPHSGRVEFRDYCLRYREDLDLVLKHINVTIEGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHNLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWMALELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDSTVLTIAHRLNTIMDYTRVIVLDKGEIRECGAPSELLQQRGVFYSMAK 1527
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|P33527|MRP1_HUMAN (Multidrug resistance-associated protein 1 OS=Homo sapiens OX=9606 GN=ABCC1 PE=1 SV=3) HSP 1 Score: 700.664 bits (1807), Expect = 0.000e+0 Identity = 447/1367 (32.70%), Postives = 733/1367 (53.62%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVADVNTMNFKRKLTSTLK--------SKNNYHTKSRRPINEHSSVW----------W---LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIR-----SVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI-SNDAI--DFMKI---------KSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIK-----SKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ I + NPCPE +S SRI F W+ I ++ ++ + ++ + V V N+K++ T K SK+ K ++ + V W L K L+ FG ++S+ H + FS P ILK L+KF++ + P + G+ + +T L ++ + FH+ + +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++IL L+ +G LA + V+VLM P+N++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + S V W P V L YV I N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + ++ + I ++N +F+W P L I SI +G LV +VG++ GK+SLL+A++ EM ++G V+IKGS++YVPQ WI+ S ++NI+ + E Y++VI+ C L DL + + G + SGGQ+QR++LARAVY ++IYL DDPLSA+DA V + +FE VI G+L N TR+ VT ++++L +D II + G I G + + D +F++ E + E+ N V + ++ + L +S S++H Q + + + E + V Y+ Y A G F SIF F + + S+YWL T DP + H + +YG +G Q I + + S+G AS+ +H +L+ +L+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + VIL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ + LNW++ ++ETN +A+ERL ++ E E + P S WP+ G++EF+ + L+Y ED F L +IN+ I GEK+GIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + +L L+HL ++ ++ L +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IV+D+GEI E+G S+++ ++S K
Sbjct: 199 SETIHDPNPCPESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDLMMFSGPQILKLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM--VPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENNILDAQTAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMS-GGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQLQRQLSSSSSYSGDISRHHNSTAELQ-----------KAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFMCNHVSALASNYWLSLWTDDP-----------------------IVNGTQEHTKVR--LSVYGALGISQGIAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1526
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Match: sp|Q8HXQ5|MRP1_BOVIN (Multidrug resistance-associated protein 1 OS=Bos taurus OX=9913 GN=ABCC1 PE=1 SV=1) HSP 1 Score: 699.893 bits (1805), Expect = 0.000e+0 Identity = 448/1369 (32.72%), Postives = 735/1369 (53.69%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVADVNTMNFKRKLTSTLK--------SKNNYHTK--SRRPINEHSSVWW-----------LTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSV-----IEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI-SNDAI--DFMKI---------KSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIK-----SKYHQ--INIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ I + NPCPE +S SRI F W+ + ++ ++S + ++ + V V N+K++ + K SK+ K S+ +NE + L K L+ FG ++S+ H + F+ P ILK L+ F++ + P + G+ I+ L ++ + FH+ + +++++A+ AVY K++ I N A+ + T EI+NLMS D + + Y ++ S+P ++IL L+ +G LA + V+VLM PLN++ + YQ M+ KD RIK M E+LN +KV+KLY+WE F + R++E+ +++ + + V W P V L+ YV + N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + I+ I +KN +F+W + P L I S+ +G LV +VG++ GK+SLL+A++ EM ++G V++KGS++YVPQ WI+ IS ++NI+ ++ E YK V+ C L DL + + G + SGGQ+QR++LARAVY S++YLLDDPLSA+DA V + +FE VI G+L N TRL VT I++L +D II + G I G + + D +F++ + E + E N V + ++ + L +S S++H +RK + E + V Y+ Y A G F SIF F + ++S+YWL T DP + H + +YG +G Q I + + S+G AS+ +H +L+ VL+S + +F ++ S ++N FSK++D +DS+IP + + +F V+ + +IL P+ ++I P+GL+YF + +FY+ S+ Q + L S SP++ FNETL G VIRA ++++ F + +++N K Y V N WL++RL+ +GN +V + + A+ R+ L+ LVGL++SYS+ + LNW++ ++ETN +A+ERL ++ E E + P +WP+ G++EF+ + L+Y ED L +IN+ I+ GEK+GIVGRTG+GK+SL LF++ E G ++IDDI+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + +L L+HL ++ ++ L+ +C + G +LSVGQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IV+D+GEI E+G S+++ ++S K
Sbjct: 199 SETINDPNPCPESSASFLSRITFWWITGMMVQGYRQPLESTDLWSLNKEDTSEQVVPVLVKNWKKECAKSRKQPVKIVYSSKDPAKPKGSSKVDVNEEAEALIVKCPQKERDPSLFKVLYKTFGPYFLMSFLFKAVHDLMMFAGPEILKLLINFVNDKKAPEWQGYFYTALLFISACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLM--VPLNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVYVTVDENNILDAQKAFVSLALFNILRFPLNILPMVISSIVQASVSLKRLRVFLSHEDLDPDSIQRRPIKDAGATNSITVKNATFTWARNDPPTLHGITFSVPEGSLVAVVGQVGCGKSSLLSALLAEMDKVEGHVTVKGSVAYVPQQAWIQNISLRENILFGRQLQERYYKAVVEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCDSDVYLLDDPLSAVDAHVGKHIFENVIGPKGLLKNKTRLLVTHAISYLPQMDVIIVM-SGGKISEMGSYQELLARDGAFAEFLRTYASAEQEQGQPEDGLAGVGGPGKEVKQMENGMLVTDTAGKQMQRQLSSSSSYSRDVSQHHTSTAELRKP--------------GPTEETWKLVEADKAQTGQVKLSVYWDYMKAIGLFISFLSIFLFLCNHVASLVSNYWLSLWTDDP-----------------------IVNGTQEHTQVR--LSVYGALGISQGITVFGYSMAVSIGGIFASRRLHLDLLHNVLRSPISFFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFNVIGACIIILLATPMAAVIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFASLFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQDMAPPKDWPQVGRVEFRDYGLRYREDLDLVLKHINVTIDGGEKVGIVGRTGAGKSSLTLGLFRIKESAEGEIIIDDINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKGFVSALPDKLNHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFDDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEWGSPSDLLQQRGLFYSMAK 1525
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A093SCZ8 (Multidrug resistance-associated protein 1 (Fragment) OS=Manacus vitellinus OX=328815 GN=N305_09668 PE=4 SV=1) HSP 1 Score: 731.865 bits (1888), Expect = 0.000e+0 Identity = 459/1353 (33.92%), Postives = 736/1353 (54.40%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTF----DVHYQCVADVNTMNFKRKLTSTLK---------SKNNYHTKSRRPINEH-----------SSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDL--DFDLRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI-SNDAI--DFMKI--KSEKSF--SDPFAEHTESIFTSNNNCVMNRNSCRI-HKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + + NPCPE +S SRI F W+ + +++ ++++ + D + + V N+ ++ + T + K + S + E SS L K L+ FG ++S+ H + F+ P ILK LL F++ P + G+ + + L ++ + FH+ T +++++AI +Y K++ I N A+ T T EI+NLMS D + + Y ++ S+PF++IL L+ +G GV V++ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+KE+ +++ + + + W P V L+ YV + N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + I +KN +FSW P+L IN ++ +G LV +VG++ GK+SLL+A++GEM +G V +KGS++YVPQ W++ + +DNII ++ E+ YK VI +C L D ++ + G + SGGQ+QR++LARAVY +++YLLDDPLSA+DA V + +FEKVI GIL N TRL VT IN+L +D I+ + + G I G + D +F++ +E+S SD + T+ N ++N ++ H+ L S S Y + + Q +S + S E + V Y+ Y A G F SIF F I + S+YWL T DP I + T Y + + +YG +G Q I + + S+G AS+ +H +L+ VL+S + +F ++ S ++N FSK+ID IDS IP + + +F V+ + VIL P+ ++I P+GL Y + +FY+ ++ Q + L S SP++ FNETL G +IRA +++K F + +++N K Y V N WL++RL+++GN +V + + A+ RNKL+ LVGL++SYS+ I LNW++ ++ETN +A+ER+ + ME E P S WP GKIEF+ + L+Y ED L NIN+ I GEKIGIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + ++L L+HL ++ S+ L+ +C + G +LSVGQRQL+CLAR +LR SKI+VLDEATA+VD ETD+LI TIK +F T+L IAHR + + D +++V++RGE++E G +++ ++S K
Sbjct: 182 SETVNDPNPCPEFSASFLSRITFWWITGLMIQGYRSPLEAKDLWSLNKDDKSEQIVPVLARNWAKEWSKTKRRPLDMLYAPKKQQKSSDSNGDVTEEAEALIIKPSQKSSEASLFKVLYKTFGPYFLMSFLFKAGHDLLMFAGPEILKLLLNFVNNKAAPDWQGYFYTVLLFVCACLQTLILHQYFHICFVTGMRLKTAIVGVIYRKALVITNSARKTSTVGEIVNLMSVDAQRFMDLATYINMIWSAPFQVILALYLLWQNLGPSVLAGVAVMILLVPINAVMAMKTKTYQVAQMKSKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELQVLKKSAYLAAMATFTWVCAPFLVALSTFAVYVTVNKNNILDAQKAFVSLALFNILRFPLNMLPMVISNIVEASVSLKRLRVFLSHEELDPDSIIRGPMPEAEGCIVVKNATFSWSKTDSPLLNSINFTVPEGSLVAVVGQVGCGKSSLLSALLGEMDKKEGYVVVKGSVAYVPQQAWVQNATLEDNIIFGREMNESRYKRVIEVCALLPDIEILPSGDKTEIGEKGVNLSGGQKQRVSLARAVYCNADVYLLDDPLSAVDAHVGKHIFEKVIGPKGILKNKTRLLVTHAINYLPQMDTILVMTD-GEISEMGSYQELLEQDGAFAEFLRTYANAEQSMENSDTNSPSTKEGKPVENGVLVNEAPGKLMHRQLSNS--STYSRDTGKSQ---QQSSTAELQKPLAEKNSWKLMEADTAKTGRVKASVYWDYMKAIGLFMSFLSIFLFLCNHIASLASNYWLSLWTDDPVI--------------------NGTQQY-----TDVRLGVYGALGISQGIAVFGYSMVVSIGGIFASRHLHHNLLHNVLRSPMSFFERTPSGNLVNRFSKEIDTIDSTIPPIIKMFMGSMFNVIGACIVILLATPIAAVIIPPLGLAYLFVQRFYVTTSRQLKRLESVSRSPVYSHFNETLLGVSIIRAFEEQKRFIKQNDMKVDENQKAYYPSIVANRWLAVRLEYVGNFIVLFAALFAVIARNKLSAGLVGLSVSYSLQITAYLNWLVRMSSEVETNIVAVERVKEYTEMEKEAEWSIEQTAPASTWPEEGKIEFRGYGLRYREDLDLVLKNINVTINGGEKIGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGINIAKIGLHDLRFKITIIPQDPILFSGSLRMNLDPFDQHSDEDIWRSLELAHLKNFVSSLPDKLNHECAEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDKLIQSTIKSQFEECTVLTIAHRLNTIMDYTRVLVLERGEVVECGSPEQLLRERGIFYSMAK 1503
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A091QFK8 (Multidrug resistance-associated protein 1 (Fragment) OS=Leptosomus discolor OX=188344 GN=N330_00597 PE=4 SV=1) HSP 1 Score: 724.546 bits (1869), Expect = 0.000e+0 Identity = 455/1361 (33.43%), Postives = 735/1361 (54.00%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ--------CVA-------------DVNTMNFKRKLTSTLKSKNNYHTKSRRPI---NEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFD---LRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSD---PFAEHTESIFTSNNNCVMNRNSCRIH----------KILHASIK--SKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + + NPCPE +S SRI F W+ + ++ ++++ + ++ + C+A +N + +K + S + ++ I ++ SS L K L+ FG ++S+ H + F+ P IL+ L+ F++ P + G+ + L ++ + FH+ T +++++AI +Y K++ I N A+ T T EI+NLMS D + + Y ++ S+P ++IL L+ +G GV V++ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+KE+ +++ + + + W P V L+ YV + N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + I +KN +FSW + P L IN ++ +G LV +VG++ GK+SLL+A++GEM +G V +KGS++YVPQ W++ + + NII ++ EN YK+VI C L D L T E+ G + SGGQ+QR++LARAVY +++YL DDPLSA+DA V + +FEKVI GIL N TR+ VT +N+L +D I+ + + G I G + +K + +F++ +A +SI S+ N + + K++H + S Y + + Q +S + S +E + V Y++Y A G L F SIF F + + S+YWL T DP I + T Y N + +YG +G Q I + + S+G AS+ +H +L+ VL+S + +F ++ S ++N FSK+ID IDS IP + + F V+ + VIL P+ ++I P+GL+YF + +FY+ ++ Q + L S SPI+ FNETL G VIRA +++ F + +++N K Y V N WL++RL+++GN +V + + A+ RNKL+ LVGL++SYS+ I LNW++ +LETN +A+ER+ + ME E P S WP GK+EF+ + L+Y ED L NIN+ I GEKIGIVGRTG+GK+SL LF++ E G ++ID ++I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + ++L L+HL ++ S+ L+ +C + G +LSVGQRQL+CLAR +LR SKI+VLDEATA+VD ETD+LI TIK +F T+L IAHR + + D +++V+DRGE++E G ++ ++S K
Sbjct: 183 SETVNDPNPCPEFSASFLSRITFWWITGLMVQGYRRPLEAKDLWSLNKEDKSEEIVPCLARNWAKEWAKTKRQPLNMLYLPKKQQKSSDSNGDVTEEAEALIIKPSQKSSEASLFKVLYKTFGPYFLMSFLFKAAHDLLMFAGPEILRLLINFVNNKGAPNWHGYFYTGLLFVCACLQTLILHQYFHICFVTGMRLKTAIVGVIYRKALVITNSARKTSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWQNLGPSVLAGVAVMILLVPINAVMAMKTKTYQVAQMKSKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELKVLKKSAYLAAMATFTWVCAPFLVALSTFAVYVTVGKNNILDAQRAFVSLALFNILRFPLNMLPMVISSIVEASVSLKRLRVFLSHEELDPDSIIRGPITEAEGCIVVKNATFSWSKNDPPSLNSINFTVPEGSLVAVVGQVGCGKSSLLSALLGEMDKKEGYVVVKGSVAYVPQQAWVQNATLEANIIFGREMNENRYKHVIEACALLPDIEILPTGDKTEI-GEKGVNLSGGQKQRVSLARAVYCNADVYLFDDPLSAVDAHVGKHIFEKVIGPKGILKNKTRVLVTHAVNYLPQMDTILVMSD-GEISEMGSYQEL---------LKQDGAFAEFLRTYANAEQSIENSDTNSPSGKEGKPLENGVLLNEAPGKLMHRQLSNSSTYSRDTGKSQH---QSSTAELQKPLAEKNSWKLTEADTAKTGRVKATVYWEYMKAIGLLISFLSIFLFVCNHVAALASNYWLSLWTDDPVI--------------------NGTQQY-----TNVRLGVYGALGISQGIAVFGYSMIVSIGGIFASRHLHLNLLHSVLRSPMSFFERTPSGNLVNRFSKEIDTIDSTIPPIIKMFMGSTFNVIGACIVILLATPIAAVIIPPLGLVYFFVQRFYVATSRQLKRLESVSRSPIYSHFNETLLGVSVIRAFEEQNRFIKQNDVKVDENQKAYYPSIVANRWLAVRLEYVGNCIVLFAALFAVIARNKLSAGLVGLSVSYSLQITAYLNWLVRMSSELETNIVAVERVKEYAEMEKEAEWSVEHTVPASTWPEEGKVEFRGYGLRYREDLDLVLKNINVTINGGEKIGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGVNIAKIGLHDLRFKITIIPQDPILFSGSLRMNLDPFDQHSDEDIWRSLELAHLKNFVSSLPDKLNHECAEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDKLIQSTIKSQFEECTVLTIAHRLNTIMDYTRVLVLDRGEVVECGSPDHLLQEKGIFYSMAK 1504
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A093CK56 (Multidrug resistance-associated protein 1 (Fragment) OS=Tauraco erythrolophus OX=121530 GN=N340_00306 PE=4 SV=1) HSP 1 Score: 722.62 bits (1864), Expect = 0.000e+0 Identity = 462/1355 (34.10%), Postives = 736/1355 (54.32%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQC----VADVNTMNFKRKLTSTLKSKNN--YHTKSR-------------------RPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFD---LRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKI-----KSEKSF--SDPFAEHTESIFTSNNNCVMNRNSCR-IHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + + NPCPE +S SRI F W+ + ++ ++++ + ++ + V N+ ++ T + N Y +K + +P ++ SS L K L+ FG ++S+ H + F+ P ILK L+ F++ P + G+ + L ++ + FH+ T +++++AI +Y K++ I N A+ T EI+NLMS D + + + Y ++ S+P ++IL L+ +G GV V++ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+KE+ +++ + + + W P V L+ YV I N V+ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + S + I +KN +FSW + P+L IN ++ +G LV +VG++ GK+SLL+A++GEM +G V +KGS++YVPQ W++ + +DNII K+ E+ YK VI C L D L T E+ G + SGGQ+QR++LARAVY ++I LLDDPLSA+DA V + +F+KVI GIL N TR+ VT IN+L +D I+ + + G I G + F + +E+S SD + + N ++N S + +H+ L S S Y + + Q +S + S E + V Y++Y A G F SIF F I + S+YWL T DP I + T Y + + +YG +G Q I + + S+G AS+ +H +L+ VL+S + +F ++ S ++N FSK+ID IDS IP + + F V+ + IL P+ ++I P+GL+Y ++ +FY+ ++ Q + L S SP++ FNETL G VIRA +++K F + +++N K Y V N WL++RL+++GN +V + + A+ RNKL+ LVGL++SYS+ I LNW++ DLETN +A+ER+ ++ ME E P S WP GK+EF+ + L+Y ED L NIN+ I GEKIGIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + ++L L+HL ++ S+ L+ +C + G +LSVGQRQL+CLAR +LR SKI+VLDEATA+VD ETD+LI TIK +F T+L IAHR + + D +++V+DRGE++E G +++ ++S K
Sbjct: 182 SETVNDPNPCPEFSASFLSRITFWWITGLMIQGYRRPLEAKDLWSLNKEDKSEEVVPGLARNWAKEWAKTKRQPLNMLYSSKKQQKSSDSNGDATEEAEALIIKP-SQKSSEASLFKVLYKTFGPYFLMSFLFKAAHDLLMFAGPQILKLLINFVTNKAAPNWQGYFYTGLMFVCACLQTLILHQYFHICFVTGMRLKTAIVGVIYRKALVITNSARKASTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVILALYLLWQNLGPSVLAGVAVMILLVPVNAVMAMKTKTYQVAQMKSKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELKVLKKSAYLAAMATFTWVCAPFLVALSTFAVYVKINKNNVLDAQKAFVSLALFNILRFPLNILPMVISSIVEASVSLKRLRVFLSHEELDPDSIVRGSVTEPEGSIVVKNATFSWSKNDPPLLNSINFTVPEGSLVAVVGQVGCGKSSLLSALLGEMDKKEGHVVVKGSVAYVPQQAWVQNATLEDNIIFGKEKNESRYKCVIEACALLPDIEILPTGDKTEI-GEKGVNLSGGQKQRVSLARAVYCNADICLLDDPLSAVDAHVGKHIFDKVIGPKGILKNKTRVLVTHAINYLPQVDTILVMTD-GEISEMGSYQELLKQDGAFAEFLRTYANAEQSMENSDTNSPSGKEGKPVENGVLVNEASGKLVHRQLSNS--STYSRDTGKSQH---QSSTAELQKPLAEKNSWKLMEADTAKTGRVKATVYWEYMKAIGLFISFLSIFLFMCNHIASLASNYWLSLWTDDPVI--------------------NGTQQY-----TDVRLGVYGALGVSQGIAVFGYSMVVSIGGIIASRHLHLNLLHDVLRSPMSFFERTPSGNLVNRFSKEIDTIDSTIPPVIKMFMGSTFNVIGACISILLATPIAAIIIPPLGLIYLLVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQKRFIKQNDMKVDENQKAYYPSIVANRWLAVRLEYVGNCIVLFAALFAVMARNKLSAGLVGLSVSYSLQITAYLNWLVRMTSDLETNVVAVERVKEYSEMEKEAEWSIEQTAPASTWPEEGKVEFRGYGLRYREDLDLVLKNINVTINGGEKIGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFDQHSDEDIWRSLELAHLRNFVSSLPDKLNHECAEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDKLIQSTIKSQFEECTVLTIAHRLNTIMDYTRVLVLDRGEVVECGSPDDLLQEKGIFYSMAK 1503
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A091S8C9 (Multidrug resistance-associated protein 1 (Fragment) OS=Nestor notabilis OX=176057 GN=N333_07742 PE=4 SV=1) HSP 1 Score: 721.85 bits (1862), Expect = 0.000e+0 Identity = 453/1366 (33.16%), Postives = 727/1366 (53.22%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPIN------------------------------EHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSD---PFAEHTESIFTSNNNCVMNRNSCRIH----------KILHASIK--SKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + + NPCPE +S SRI F W+ + ++ ++++ + ++ + ++ R T + R+P+N + SS L K L+ FG ++S+ H + F+ P ILK L++F++ P + G+ + L ++ + FH+ T +++++AI +Y K++ I N A+ T T EI+NLMS D + + Y ++ S+PF++IL L+ +G GV V++ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+KE+ +++ + + + W P V L+ YV I N ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + S I +KN +FSW + P L IN ++ +G LV +VG++ GK+SLL+A++GEM +G V +KGS++YVPQ W++ + +DNII ++ E+ YK VI C L D+ A + G + SGGQ+QR++LARAVY +++ L DDPLSA+DA V + +FE VI GIL N TR+ VT IN+L +D I+ + + G I G + +K + +F++ +A +S+ S+ N + + K++H + S Y + + Q ++S + S +E + V Y+ Y A G F SIF F I + S+YWL T DP I + T Y N + +YG +G Q I + + S+G AS+ +H +L+ VL+S + +F ++ S ++N FSK++D IDS IP + + F V+ + +IL P+ ++I P+GL+Y + +FY+ ++ Q + L S SP++ FNETL G VIRA +++K F + +++N K Y V N WL++RL+++GN +V + + A+ RNKL+ LVGL++SYS+ I LNW++ +LETN +A+ER+ + ME E P S WP GKIEF+ + L+Y ED L NIN+ I GEKIGIVGRTG+GK+SL LF++ E G ++ID ++I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + +L L+HL ++ S+ L+ DC + G +LSVGQRQL+CLAR +LR SKI+VLDEATA+VD ETD+LI TIK +F T+L IAHR + + D +++V+DRGE++E G ++ ++S K
Sbjct: 183 SETVNDPNPCPEFSASFLSRITFWWITGLMVQGYRRPLEAKDLWSLNKEDKSEEIVPGLARNWT------KEWAKAKRQPLNIVYSPKKQQKPSDSNGDVTEEAEALIIKPSQKSSEASLFKVLYKTFGPYFLMSFLFKAAHDLLMFAGPEILKLLIRFVNNKAAPDWQGYFYTGLLFVCACLQTLILHQYFHICFVTGMRLKTAIVGVIYRKALVITNSARKTSTVGEIVNLMSVDAQRFMDLATYINMIWSAPFQVILALYLLWQNLGPSVLAGVAVMILLVPVNAVMAMKTKTYQVAQMKSKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELKVLKKSAYLAAMATFTWVCAPFLVALSTFAVYVTIDKNNILDAQKAFVSLALFNILRFPLNMLPMVISSIVEASVSLKRLRVFLSHEELDPDSIIRSPITAAEGCIVVKNATFSWSKNDPPFLNSINFTVPEGSLVAVVGQVGCGKSSLLSALLGEMDKKEGYVVVKGSVAYVPQQAWVQNATLQDNIIFGREVNESRYKRVIEACALLPDIEILPAGDKTEIGEKGVNLSGGQKQRVSLARAVYCNADVCLFDDPLSAVDAHVGKHIFENVIGPKGILKNKTRVLVTHAINYLPQMDTILVMSD-GEISEMGSYQEL---------LKQDGAFAEFLRTYANTEQSMENSDTNSPSGKEGKPVENGILVNEAPGKLMHRQLSNSSTYSRDTGKSQH---HSSTAELQKPLAEKNSWKLTEADTAKTGRVKATVYWDYMKAIGLFISFLSIFLFMCNHIASLASNYWLSLWTDDPVI--------------------NGTQQY-----TNVRLGVYGALGISQGIAVFGYSMVVSIGGIFASRHLHLNLLHSVLRSPMSFFERTPSGNLVNRFSKELDTIDSAIPPIIKMFMGSTFNVIGACIIILLATPIAAVIIPPLGLVYLFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQKRFIKQNDIKVDENQKAYYPSIVANRWLAVRLEYVGNCIVLFAALFAVMARNKLSAGLVGLSVSYSLQITAYLNWLVRMSSELETNIVAVERVKEYAEMEKEAEWSIEQTAPASTWPEEGKIEFRGYGLRYREDLDLVLKNINVTINGGEKIGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGVNIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFDQRSDEDIWTSLELAHLKNFVSSLPDKLNHDCAEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDKLIQSTIKSQFEECTVLTIAHRLNTIMDYTRVLVLDRGEVVECGSPEHLLQQKGIFYSMAK 1504
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Match: A0A091GNP1 (Multidrug resistance-associated protein 1 (Fragment) OS=Cuculus canorus OX=55661 GN=N303_11864 PE=4 SV=1) HSP 1 Score: 720.694 bits (1859), Expect = 0.000e+0 Identity = 451/1353 (33.33%), Postives = 731/1353 (54.03%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVAD---------------------VNTMNFKRKLTSTLKSKNNYHTKSRRPI---NEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFD---LRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDEN--GSIKYYGDVSNISNDAIDFMKI--KSEKSF--SDPFAEHTESIFTSNNNCVMNRNSCR-IHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ + + NPCPE +S SRI F W+ + ++ ++++ + +H + ++ +N + +K + SK + ++ I ++ SS L KAL+ FG ++S+ H + F+ P ILK L+ F++ P + G+ + L ++ + FH+ T +++++A+ +Y K++ I N A+ T T EI+NLMS D +++ Y ++ S+PF++IL L+ +G GV V++ P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + + R+KE+ +++ + + + W P V L+ YV ++ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + I +KN +FSW + P L IN ++ +G L+ +VG++ GK+SLL+A++GEM +G V +KGS++YVPQ W++ + +DNII ++ EN YK VI C L D L T E+ G + SGGQ+QR++LARAVY +++YL DDPLSA+DA V + +FEKVI GIL N TR+ VT +N+L +D I+ + E + Y D+ +F++ +E+S SD + + N ++N + IH+ L S ++Q +S + S +E + V Y+ Y A G S+F F I + S+YWL T DP + + T Y N + +YG +G Q I + + S+G AS+ +H +L+ VL+S + +F ++ S ++N FSK+ID IDS IP + + F V+ + +IL P+ ++I P+GL+Y + +FY+ ++ Q + L S SP++ FNETL G VIRA +++K F + +++N K Y V N WL++RL+F+GN +V + + A+ RNKL+ LVGL++SYS+ I LNW++ +LETN +A+ER+ + ME E P S WP GK+EF+ + L+Y ED L NIN+ I GEKIGIVGRTG+GK+SL LF++ E G ++ID I+I I + D+R IT+ PQ+ +FSG++R N+DPF+ D + ++L L+HL ++ S+ L+ +C + G +LSVGQRQL+CLAR +LR SKI+VLDEATA+VD ETD+LI TIK +F T+L IAHR + + D +++V++RG+++E G ++ ++S K
Sbjct: 186 SETVNDPNPCPEFSASFLSRITFWWITGLMVQGYRRPLEAKDLWSLHKEDKSEEIVPGLARNWAKEWAKTKRQPLNMLYSLKKQQKSSDSKGDVTEEAEALIIKPSQKSSEASLFKALYKTFGPYFLMSFLFKAAHDLLMFAGPEILKLLINFVNNKAAPDWQGYFYTGLLFVCACLQTLILHQYFHICFVTGMRLKTAVVGVIYRKALVITNSARKTSTVGEIVNLMSVDAQRLMDLATYINMIWSAPFQVILALCLLWQNLGPSVLAGVAVMILLVPINAVMAMKTKTYQVAQMKCKDNRIKLMNEILNGIKVLKLYAWELAFREKVLEIRQKELKVLKKSAYLAAMATFTWVCAPFLVALSTFAVYVTTDKKNILDAQKAFVSLALFNILRFPLNMLPMVISSIVEASVSLKRLRVFLSHEELDPDSIIRGPITEAEGCIVVKNATFSWSKNDPPSLNSINFTVPEGSLIAVVGQVGCGKSSLLSALLGEMDKKEGYVVVKGSVAYVPQQAWVQNATLQDNIIFGREMNENRYKRVIEACALIPDIEVLPTGDKTEI-GEKGVNLSGGQKQRVSLARAVYCNADVYLFDDPLSAVDAHVGKHIFEKVIGPKGILKNKTRVLVTHAVNYLPQMDTILVMTEGEISEMGSYQDLLKQDGAFAEFLRTYANTEQSMENSDTNSPSGKEGKPVENGVLVNEAPGKLIHRQLSNSSTCSRDTGKSQQQ-----SSTAELQKPLAEKNSWKLTEADTAKTGRVKVTVYWDYMKALGLFISSFSVFLFMCNHIAALASNYWLSLWTDDPVV--------------------NGTQQY-----TNVRLGVYGALGTSQGIAVFGYSMAVSIGGIFASRHLHLNLLHSVLRSPMSFFERTPSGNLVNRFSKEIDTIDSTIPPIIKMFMGSTFNVIGACIIILLATPIAAVIIPPLGLVYLFVQRFYVATSRQLKRLESVSRSPVYSHFNETLLGVTVIRAFEEQKRFIKQNDMKVDENQKAYYPSIVANRWLAVRLEFVGNCIVLFAALFAVMARNKLSAGLVGLSVSYSLQITAYLNWLVRMSSELETNIVAVERVKEYTEMEKEAEWSIEQTAPASTWPEEGKVEFRGYGLRYREDLDLVLKNINVTINGGEKIGIVGRTGAGKSSLTLGLFRINEAAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFDQHSDEDIWRSLELAHLKNFVSSLPDKLNHECAEGGENLSVGQRQLVCLARALLRKSKILVLDEATAAVDLETDQLIQSTIKSQFKECTVLTIAHRLNTIMDYTRVLVLERGKVVECGSPEHLLQEKGIFYSMAK 1507
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969]) HSP 1 Score: 708.368 bits (1827), Expect = 0.000e+0 Identity = 453/1356 (33.41%), Postives = 735/1356 (54.20%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVA-----------DVNTMNFKRKLTSTL---KSKNNYHTKSRRPINE----------HSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFG-FTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSV------IEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFL-----DENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ ++++NPCPE +S SRI F W+ + ++ ++ + + ++ + + D KR T+ K + K RP+ E S L AL FG ++S + H + F P IL+ L++F++ + P + G F A+ F+ T + I Q FH+ T +++R+AI AVY K++ I N A+ T T EI+NLMS D + + I Y ++ S+P ++IL FL+ +G LA + V+VLM P+N++ + YQ +M+ KD RIK M EVLN +KV+KLY+WE F +S RE E+ +++ + + W P V L+ YV + + V+ A+ FVS+ L N+LR P+ +LP I+ + VS+KR+ +FL + + D R++ I I +G+FSW + P LKRIN+ I +G LV +VG + SGK+SLL+A++GEM +G VSIKGS++YVPQ WI+ + ++NI+ ++ E+ Y+ V+ C L DL + G + SGGQ+QR++LARAVY +YLLDDPLSA+DA V + +FEKVI G+L TR+ VT ++FL D I+ + E GS Y ++ N DF++ + + E + + RN+ +H S S + Q +N K + + + ++++ +T V +++Y A G F SI F + + S+YWL T DP I + + +YG +G Q I + ++ S+G AS+ +H+ ML VL+S + +F ++ S ++N F+K+ D IDS+IP+ + + +F V+ S VIL PL ++I P+GLLYF + +FY+ S+ Q + L S SP++ FNETL G VIRA +++ F E + ++ N K + V N WL++RL+F+GN +V + + A+ R L+P ++GL+ISY++ + LNW++ ++ETN +A+ER+ + E E K + WP G IE + F L+Y ED + +++I ++IE GEK+GIVGRTG+GK+SL LF+++E G + ID ++I ++ + D+R IT+ PQ+ +FSG++R N+DPF+ D + +AL L+HL ++ + L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D +++V+D+G++ EF + +I ++ K
Sbjct: 199 SQAVKDSNPCPEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPSMAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYFLVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAPSWHGYFYTALLFVCTCFQTLILQKY-FHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLM--VPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELRVLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFLSHEELDE---NSVDRRAITGSADSIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVMVDGEITETGS---YTELLNRQGAFADFLRTYANAE------QDGEPDGMTGKKEKLQRNTTFVHFFPRQSQSSLNTPGAAKPQQKAESNDTQAKKTKSPDAAKLTEADKANT--GRVKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTDDPVI-------------------------NGTQPSREMRLGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYKMAK 1512 HSP 2 Score: 84.3445 bits (207), Expect = 9.611e-16 Identity = 60/230 (26.09%), Postives = 110/230 (47.83%), Query Frame = 2
Query: 3830 YVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI---KHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLY 4510
+ ++ + L IN+ I G + +VG GSGK+SL+ +L + G + ++ ++ PQ++ I + T+R+NI ++ ++ L L P LE + G + G+ G +LS GQ+Q + LAR + + + +LD+ ++VD + I E + + T +++ H S L D I+VM GEI E G +E++N + + Y
Sbjct: 650 WSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDV-------------SIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVMVDGEITETGSYTELLNRQGAFADFLRTY 866
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc1 (ATP binding cassette subfamily C member 1 [Source:NCBI gene;Acc:103043969]) HSP 1 Score: 706.057 bits (1821), Expect = 0.000e+0 Identity = 447/1351 (33.09%), Postives = 726/1351 (53.74%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVA-----------DVNTMNFKRKLTSTL---KSKNNYHTKSRRPINE----------HSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFG-FTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSV------IEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ ++++NPCPE +S SRI F W+ + ++ ++ + + ++ + + D KR T+ K + K RP+ E S L AL FG ++S + H + F P IL+ L++F++ + P + G F A+ F+ T + I Q FH+ T +++R+AI AVY K++ I N A+ T T EI+NLMS D + + I Y ++ S+P ++IL FL+ +G LA + V+VLM P+N++ + YQ +M+ KD RIK M EVLN +KV+KLY+WE F +S RE E+ +++ + + W P V L+ YV + + V+ A+ FVS+ L N+LR P+ +LP I+ + VS+KR+ +FL + + D R++ I I +G+FSW + P LKRIN+ I +G LV +VG + SGK+SLL+A++GEM +G VSIKGS++YVPQ WI+ + ++NI+ ++ E+ Y+ V+ C L DL + G + SGGQ+QR++LARAVY +YLLDDPLSA+DA V + +FEKVI G+L TR+ VT ++FL D I+ + +G I G + + N F + ++ E + + N + + +S+ + +K S + + +E V +++Y A G F SI F + + S+YWL T DP I + + +YG +G Q I + ++ S+G AS+ +H+ ML VL+S + +F ++ S ++N F+K+ D IDS+IP+ + + +F V+ S VIL PL ++I P+GLLYF + +FY+ S+ Q + L S SP++ FNETL G VIRA +++ F E + ++ N K + V N WL++RL+F+GN +V + + A+ R L+P ++GL+ISY++ + LNW++ ++ETN +A+ER+ + E E K + WP G IE + F L+Y ED + +++I ++IE GEK+GIVGRTG+GK+SL LF+++E G + ID ++I ++ + D+R IT+ PQ+ +FSG++R N+DPF+ D + +AL L+HL ++ + L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D +++V+D+G++ EF + +I ++ K
Sbjct: 199 SQAVKDSNPCPEAGASFLSRISFWWITGLMVQGYKRPLEEKDLWSLNAEDRSHTVVPQLVRRWDHECSKGKRTDDKTMYSPKRPSMAEKKDGRPVEESEILLIKAPQKSGDPSLFLALCRTFGPYFLVSSIYKIIHDVLMFVGPEILRLLIQFVNDSDAPSWHGYFYTALLFVCTCFQTLILQKY-FHVCFVTGMRLRTAIVGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGPSVLAGVAVMVLM--VPVNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKDKVSTIRESELRVLKKAAYLGAISTFTWVCAPFLVALSTFAVYVLVDEHNVLDAQKAFVSLALFNILRFPLNMLPMVISSMVQASVSMKRLRVFLSHEELDE---NSVDRRAITGSADSIRIGDGAFSWSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDVSIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVM-VDGEITETGSYTELLNRQGAFADFLRTYANAEQDGEPDGMTDGAPRKTLENGGPAAVLRQSQSSLNTPGAAKPQQK-----AESNDTQAKKTKSPDAAKLTEADKANTGRVKLAVFWEYMKAIGVFLSFISILLFLAHHVSSLGSNYWLSLWTDDPVI-------------------------NGTQPSREMRLGVYGALGLSQGIAVFCYSISVSIGGILASRYLHETMLYNVLRSPMSFFERTPSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRFYVASSRQLKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIGESDRRVDHNQKAYFPSIVANRWLAVRLEFVGNCIVTFAALFAVMARANLSPGIMGLSISYALQVTASLNWLVRMSSEVETNIVAVERVKEYEDTEKEAEWKLEQSSVPAGWPTAGHIEVRNFGLRYREDLELAIHDITVIIEGGEKVGIVGRTGAGKSSLTLGLFRIIEAAQGEICIDGVNIANLGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDGYSDEDVWRALELAHLKNFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGKMAEFDSPASLIAKKGIFYKMAK 1512 HSP 2 Score: 84.3445 bits (207), Expect = 1.037e-15 Identity = 60/230 (26.09%), Postives = 110/230 (47.83%), Query Frame = 2
Query: 3830 YVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI---KHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLY 4510
+ ++ + L IN+ I G + +VG GSGK+SL+ +L + G + ++ ++ PQ++ I + T+R+NI ++ ++ L L P LE + G + G+ G +LS GQ+Q + LAR + + + +LD+ ++VD + I E + + T +++ H S L D I+VM GEI E G +E++N + + Y
Sbjct: 650 WSKEDRPALKRINVRIPEGALVAVVGHVGSGKSSLLSALLGEMHKQEGDV-------------SIKGSVAYVPQQAWIQNATLRENIMFGQEKKESWYQKVLEACALLPDLEILPGGDTTEIGEKGVNLSGGQKQRVSLARAVYCDCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGVLQGRTRVLVTHGLSFLPQADLILVMVDGEITETGSYTELLNRQGAFADFLRTY 866
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc3 (ATP binding cassette subfamily C member 3 [Source:NCBI gene;Acc:103023748]) HSP 1 Score: 696.427 bits (1796), Expect = 0.000e+0 Identity = 432/1372 (31.49%), Postives = 723/1372 (52.70%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTS---------------TLKSKNNYHT--------------KSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENK--TKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKII---------------FLDENGS----IKYYGDVSNISNDAIDFMKIKSEKSFS-DPFAEHTESIFTSNNNCVMN---RNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+SV+ + NPCPE + SR+ F W +++ ++++ + ++ Q +++ R+ + SK T S++ + S ++L FG +I + + +F P +L+ L++F P ++GF LA +L ++ + F T +++R+AI A+Y KS+ I NEAK + T E++NLMS D + + + ++ S+P +IIL FL+ +G GV V++ P N++ + YQ E+M++KD RIK M E+LN +KV+KLY+WE F + + + R+KE+N++R + S + + W + P V LT YV++ N V+ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ FL ++ N + + NG FSW P L+ IN+ + +G L+ +VG + GK+SL+ A++GEM L+G +SI+GS++YVPQ WI+ + +DNI+ + Y+E Y+ V+ C L DL +L G + SGGQRQR++LARA+Y ++++YL+DDPLSA+DA VA+ +F+ VI G L TR+ VT I+FL +D I+ L +NG+ ++ Y I D + + I E+SF D + HT+ + +N +N R R I+ +++ + +IRK+ + + + E V +K Y++Y A G + F + + + ++ WL + T+D + + +T H +Y +G Q I F T ++G A++ +H +L+ + +F + +I+N FSKDI ID +P+ + + F +A+ VI+ + P+F ++IVP+ L+YF + +FY+ ++ Q + L S SPI+ F+ET+ G VIRA + F +++N K Y V N WL +R++F+GN +V + + A+ + L+P LVGL++SY++ + LNWM+ DLE+N +A+ER+ ++ E + P ++WP G +EF ++++Y E L NI+L ++ GEKIGIVGRTG+GK+S+ LF+L+E GG + ID + I++I + D+R +T+ PQE +FSGT+R N+DPF D + AL LSHL ++ + L +C + G +LSVGQRQL+CLAR +LR ++I++LDEATA++D ETD LI TI+ +F + T+ IAHR + + D +I+V+D+G+I EF +I ++S K
Sbjct: 192 SSVVTDPNPCPESTAGFLSRMTFWWFTSMAIKGYKSPLETKDLWSLNKQDSSELVVPKLLREWEGEKSKAQSIEQDVNGQAVYSKAGAETNHVEVNPEEVEVLLSSKKDTPQPS----FLRSLLKAFGPYFLIGSAFKLLQDLITFINPQLLRMLIEFTKETGVPSWWGFALAFMMFGCALLQTLILHQHFQYCFVTGMRLRTAIIGAIYRKSLVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIILALFFLWQTLGPSVLAGVAVMVLLIPFNAVIAMKTRAYQVEQMQYKDARIKLMNEILNGIKVLKLYAWEVSFKEKVLQIRQKELNVLRKTAYLSALSTMAWTSAPFLVALTTFAVYVSVDKNNVLDADKAFVSLSLFNILRFPLNMLPQVISSLVQASVSLKRIQAFLSHDELDPDNVDKKPAPSDHAVTVVNGKFSWAKKDPPALQHINVMVPQGSLLAVVGHVGCGKSSLVAALLGEMEKLEGHISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLMDDPLSAVDAHVAKHIFDHVIGPEGALRGKTRILVTHGISFLPQVDNILVLVEGMVSEMGSYQDLLKQNGAFAEFLRNYSLEDIIEEDEVTEVLIDEEESFPDDALSNHTDMV---DNEPAVNEARRQFMRQISIMSNDLENPKTK-SIRKRRCSERRPGEPPQEKKEPKVEKLIQAE-TAETGRVKFKVYWEYAKAVGPILSLFICFLYASQSAAAIGANIWLSQWTND--------------------SRDSVTAQEKVHMRVG----VYASLGITQGILVMFSSFTLAMGKIQAARKLHQGLLDNKFHTPQAFFDTTPLGRIINRFSKDIYVIDEALPSTILMFLGTFFASVATMIVIVSSTPIFAVVIVPLALVYFFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGTSVIRAYGRNSAFVLMSDMKVDENQKSYYPGIVSNRWLGIRIEFIGNCIVLFAAVFAVLEKENLSPGLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETPPEAPWEVEDKKPPTDWPSEGNVEFADYSVRYREGLDLVLRNISLRVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAGGEITIDGVKIKEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFEKYSDDDMWNALTLSHLHKFVSNQPAKLALECSEGGENLSVGQRQLICLARALLRKTRILILDEATAAIDLETDDLIQSTIRTQFEDCTVFTIAHRLNTIMDYTRILVLDKGQIAEFDTPVNLIAQKGIFYSMAK 1530
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc3 (ATP binding cassette subfamily C member 3 [Source:NCBI gene;Acc:103023748]) HSP 1 Score: 694.886 bits (1792), Expect = 0.000e+0 Identity = 431/1367 (31.53%), Postives = 719/1367 (52.60%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTS---------------TLKSKNNYHT--------------KSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENK--TKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKII---------------FLDENGS----IKYYGDVSNISNDAIDFMKIKSEKSFS-DPFAEHTESIFTSNNNCVMN---RNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
N NPCPE + SR+ F W +++ ++++ + ++ Q +++ R+ + SK T S++ + S ++L FG +I + + +F P +L+ L++F P ++GF LA +L ++ + F T +++R+AI A+Y KS+ I NEAK + T E++NLMS D + + + ++ S+P +IIL FL+ +G GV V++ P N++ + YQ E+M++KD RIK M E+LN +KV+KLY+WE F + + + R+KE+N++R + S + + W + P V LT YV++ N V+ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ FL ++ N + + NG FSW P L+ IN+ + +G L+ +VG + GK+SL+ A++GEM L+G +SI+GS++YVPQ WI+ + +DNI+ + Y+E Y+ V+ C L DL +L G + SGGQRQR++LARA+Y ++++YL+DDPLSA+DA VA+ +F+ VI G L TR+ VT I+FL +D I+ L +NG+ ++ Y I D + + I E+SF D + HT+ + +N +N R R I+ +++ + +IRK+ + + + E V +K Y++Y A G + F + + + ++ WL + T+D + + +T H +Y +G Q I F T ++G A++ +H +L+ + +F + +I+N FSKDI ID +P+ + + F +A+ VI+ + P+F ++IVP+ L+YF + +FY+ ++ Q + L S SPI+ F+ET+ G VIRA + F +++N K Y V N WL +R++F+GN +V + + A+ + L+P LVGL++SY++ + LNWM+ DLE+N +A+ER+ ++ E + P ++WP G +EF ++++Y E L NI+L ++ GEKIGIVGRTG+GK+S+ LF+L+E GG + ID + I++I + D+R +T+ PQE +FSGT+R N+DPF D + AL LSHL ++ + L +C + G +LSVGQRQL+CLAR +LR ++I++LDEATA++D ETD LI TI+ +F + T+ IAHR + + D +I+V+D+G+I EF +I ++S K
Sbjct: 155 NKNPCPESTAGFLSRMTFWWFTSMAIKGYKSPLETKDLWSLNKQDSSELVVPKLLREWEGEKSKAQSIEQDVNGQAVYSKAGAETNHVEVNPEEVEVLLSSKKDTPQPS----FLRSLLKAFGPYFLIGSAFKLLQDLITFINPQLLRMLIEFTKETGVPSWWGFALAFMMFGCALLQTLILHQHFQYCFVTGMRLRTAIIGAIYRKSLVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIILALFFLWQTLGPSVLAGVAVMVLLIPFNAVIAMKTRAYQVEQMQYKDARIKLMNEILNGIKVLKLYAWEVSFKEKVLQIRQKELNVLRKTAYLSALSTMAWTSAPFLVALTTFAVYVSVDKNNVLDADKAFVSLSLFNILRFPLNMLPQVISSLVQASVSLKRIQAFLSHDELDPDNVDKKPAPSDHAVTVVNGKFSWAKKDPPALQHINVMVPQGSLLAVVGHVGCGKSSLVAALLGEMEKLEGHISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLMDDPLSAVDAHVAKHIFDHVIGPEGALRGKTRILVTHGISFLPQVDNILVLVEGMVSEMGSYQDLLKQNGAFAEFLRNYSLEDIIEEDEVTEVLIDEEESFPDDALSNHTDMV---DNEPAVNEARRQFMRQISIMSNDLENPKTK-SIRKRRCSERRPGEPPQEKKEPKVEKLIQAE-TAETGRVKFKVYWEYAKAVGPILSLFICFLYASQSAAAIGANIWLSQWTND--------------------SRDSVTAQEKVHMRVG----VYASLGITQGILVMFSSFTLAMGKIQAARKLHQGLLDNKFHTPQAFFDTTPLGRIINRFSKDIYVIDEALPSTILMFLGTFFASVATMIVIVSSTPIFAVVIVPLALVYFFVQRFYVATSRQLKRLESVSRSPIYSHFSETITGTSVIRAYGRNSAFVLMSDMKVDENQKSYYPGIVSNRWLGIRIEFIGNCIVLFAAVFAVLEKENLSPGLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETPPEAPWEVEDKKPPTDWPSEGNVEFADYSVRYREGLDLVLRNISLRVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAGGEITIDGVKIKEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFEKYSDDDMWNALTLSHLHKFVSNQPAKLALECSEGGENLSVGQRQLICLARALLRKTRILILDEATAAIDLETDDLIQSTIRTQFEDCTVFTIAHRLNTIMDYTRILVLDKGQIAEFDTPVNLIAQKGIFYSMAK 1488
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Match: abcc3 (ATP binding cassette subfamily C member 3 [Source:NCBI gene;Acc:103023748]) HSP 1 Score: 691.804 bits (1784), Expect = 0.000e+0 Identity = 434/1372 (31.63%), Postives = 721/1372 (52.55%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTS---------------TLKSKNNYHT--------------KSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENK--TKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKII---------------FLDENGS----IKYYGDVSNISNDAIDFMKIKSEKSFS-DPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQ---IIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+SV+ + NPCPE + SR+ F W +++ ++++ + ++ Q +++ R+ + SK T S++ + S ++L FG +I + + +F P +L+ L++F P ++GF LA +L ++ + F T +++R+AI A+Y KS+ I NEAK + T E++NLMS D + + + ++ S+P +IIL FL+ +G GV V++ P N++ + YQ E+M++KD RIK M E+LN +KV+KLY+WE F + + + R+KE+N++R + S + + W + P V LT YV++ N V+ A+ FVS+ L N+LR P+ +LP I+ + VSLKR+ FL ++ N + + NG FSW P L+ IN+ + +G L+ +VG + GK+SL+ A++GEM L+G +SI+GS++YVPQ WI+ + +DNI+ + Y+E Y+ V+ C L DL +L G + SGGQRQR++LARA+Y ++++YL+DDPLSA+DA VA+ +F+ VI G L TR+ VT I+FL +D I+ L +NG+ ++ Y I D + + I E+SF D + HT+ + R R I+ +++ + +IRK+ + + + E V +K Y++Y A G + F + + + ++ WL + T+D + + +T H +Y +G Q I+ C +S+ A+ A H ML+ VL++ +F + S ++LN FSKD+D IDSLIP+N+ + + + V P+FL++IVP+ + Y+ + +FY+ ++ Q + L S SPI+ F+ET+ G VIRA + F +++N K Y V N WL +R++F+GN +V + + A+ + L+P LVGL++SY++ + LNWM+ DLE+N +A+ER+ ++ E + P ++WP G +EF ++++Y E L NI+L ++ GEKIGIVGRTG+GK+S+ LF+L+E GG + ID + I++I + D+R +T+ PQE +FSGT+R N+DPF D + AL LSHL ++ + L +C + G +LSVGQRQL+CLAR +LR ++I++LDEATA++D ETD LI TI+ +F + T+ IAHR + + D +I+V+D+G+I EF +I ++S K
Sbjct: 192 SSVVTDPNPCPESTAGFLSRMTFWWFTSMAIKGYKSPLETKDLWSLNKQDSSELVVPKLLREWEGEKSKAQSIEQDVNGQAVYSKAGAETNHVEVNPEEVEVLLSSKKDTPQPS----FLRSLLKAFGPYFLIGSAFKLLQDLITFINPQLLRMLIEFTKETGVPSWWGFALAFMMFGCALLQTLILHQHFQYCFVTGMRLRTAIIGAIYRKSLVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIILALFFLWQTLGPSVLAGVAVMVLLIPFNAVIAMKTRAYQVEQMQYKDARIKLMNEILNGIKVLKLYAWEVSFKEKVLQIRQKELNVLRKTAYLSALSTMAWTSAPFLVALTTFAVYVSVDKNNVLDADKAFVSLSLFNILRFPLNMLPQVISSLVQASVSLKRIQAFLSHDELDPDNVDKKPAPSDHAVTVVNGKFSWAKKDPPALQHINVMVPQGSLLAVVGHVGCGKSSLVAALLGEMEKLEGHISIRGSVAYVPQQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVSLARALYSEADVYLMDDPLSAVDAHVAKHIFDHVIGPEGALRGKTRILVTHGISFLPQVDNILVLVEGMVSEMGSYQDLLKQNGAFAEFLRNYSLEDIIEEDEVTEVLIDEEESFPDDALSNHTDMVDNEPAVNEARRQFMRQISIMSNDLENPKTK-SIRKRRCSERRPGEPPQEKKEPKVEKLIQAE-TAETGRVKFKVYWEYAKAVGPILSLFICFLYASQSAAAIGANIWLSQWTND--------------------SRDSVTAQEKVHMRVG----VYASLGITQGVLILANCLLCRAYSM--LKAAHATHLTMLHAVLRAPQAFFEATPSGRLLNRFSKDVDTIDSLIPDNIDIWMRTFWYTVNVLLVCSALTPMFLIVIVPLMMFYWWVQRFYVATSRQLKRLESVSRSPIYSHFSETITGTSVIRAYGRNSAFVLMSDMKVDENQKSYYPGIVSNRWLGIRIEFIGNCIVLFAAVFAVLEKENLSPGLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETPPEAPWEVEDKKPPTDWPSEGNVEFADYSVRYREGLDLVLRNISLRVKGGEKIGIVGRTGAGKSSMTLCLFRLLEAAGGEITIDGVKIKEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFEKYSDDDMWNALTLSHLHKFVSNQPAKLALECSEGGENLSVGQRQLICLARALLRKTRILILDEATAAIDLETDDLIQSTIRTQFEDCTVFTIAHRLNTIMDYTRILVLDKGQIAEFDTPVNLIAQKGIFYSMAK 1531
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: abcc3 (ATP-binding cassette, sub-family C (CFTR/MRP), member 3 [Source:ZFIN;Acc:ZDB-GENE-050517-16]) HSP 1 Score: 330.487 bits (846), Expect = 8.511e-93 Identity = 199/651 (30.57%), Postives = 340/651 (52.23%), Query Frame = 2
Query: 572 ENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDV-----------HYQCV-------------ADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYF--SSCQDIR-SVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNI 2437
++ N CPE +S SR+ F W R + ++ G+K + + H Q V +T RKL +T KS++ + S L +A+ FG + ++ + I SF+ P +L +L++F+ P + G+ LA + I +S+ + FH T +++RSA+ +Y K++ I A+ + E+ LMS D + V S+P I L FL+ +G GV V++ P N+ ++ Q + ++ +D+R++ ++E L+ +++IK+Y+WE F +I R RE E+ ++ + S + W P V L YV + ++V+ AE FVS+ L N+LR P+ LP ++ VSL+R+ FL + + S +R S + I+ G+F+W D PIL I++++ +G L+ +VG + SGK+SL+ A++GE+ L G+V++KG ++YV Q WI+ S +DN++ + E Y+ V++ C L+ DL A + G + SGGQRQR++LARA+Y K+ ++LLDDPLSA+DA V + +FE+VI +G+LA TR+ VT ++FL ++D+I+ L G + G S +
Sbjct: 184 DDPNLCPEVGASFISRLTFCWFTRMAVNGYRRGLKMSDLWSLRHKDSCSFVVPHLQAVWRKEQARIAQRSAVSQSTPAETRKLHTTEKSQSGGAGTEGGATGQEPS---LIRAMALAFGPRYLVGSVYKLLQDILSFASPLLLSHLIRFVGDNSRPTWHGYALAGLMFLCAIATSMLAHQHFHAGFVTGIRLRSALTGLLYRKALMITQAARLSCAGGELTTLMSVDVQHMADITNNLNFVWSAPLHICLAMYFLWQHLGPSVLAGVAVMLLLIPFNAFIALNIRTLQAQIIKKRDERVRTLSEALSGVRIIKMYAWEGRFRDVILRVREHELAVLGRAAYFSMLSAFTWLCSPFLVALASFGVYVLVDEHHVLDAERAFVSLALFNLLRYPLNQLPQLMSELAMASVSLRRLRNFLSLEELDPHAVDRSPSHLRESCVSIEGGTFTWSWDEPPILHDISLAVPRGCLLAVVGTVGSGKSSLMAALLGELNKLGGSVAVKGQVAYVAQQAWIQN-SLRDNVLFGRPLDETWYREVLQACALEQDLLALPAGDNTEIGEKGINLSGGQRQRVSLARAIYSKASVFLLDDPLSAVDAHVGKHIFERVIGPSGLLAGQTRVLVTHGLSFLPHVDRIVVLTA-GRVSESGSYSEL 829 HSP 2 Score: 291.967 bits (746), Expect = 1.866e-80 Identity = 169/521 (32.44%), Postives = 298/521 (57.20%), Query Frame = 2
Query: 2966 NYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNN----LSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYI-----QNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSK 4498
Y + +Y +G Q + + L G A+ ++H +L+ L S + ++ + +I+N FSKD+ ID ++P L + N IF ++ +I+ + P+F++ +P+ ++YF + +FY+ ++ Q + L SP+F F E++ G +RA +Q++ F + ++ + Y + V +WL +FLG +V + + A+ R+ L VGL++SY++ + +++WM+ ++E+N +A+ER+ ++ E + + P ++WP G +EF+ ++ +Y E L NI+ I+ GEK+GIVGRTG+GK+SL L ++VE G++ ID +DI I + D+R IT+ PQ+ +F G++R N+DPF D + +AL +HLG ++ G + +C + G + SVGQRQL CLAR +LR ++++VLDEATA+VD ETD LI TI+ F T+L IAHR + D +++V+ G+I+EF +++ + F K
Sbjct: 996 GYRLGVYSALGAVQSVLSLVMVLMVFKGCLRAAGSLHLALLDNKLHSPISFYDVTPLGRIINRFSKDVFMIDEVLPPTFLMFLGALCNSIFTIL----IIVISTPVFVVAAIPLVVIYFFVQRFYVATSRQLKRLESTVRSPVFSHFGESVAGAATLRAFRQEERFVIAGDRAVDALQRTSYPSIVSQRRVGAVWL----EFLGACVVLFAAMFAVLSRDSLKAGTVGLSVSYAMQVTVVMSWMVRMSSEVESNIVAVERVKEYSETPPEADWEVESCRPPADWPSQGHVEFRDYSTRYREGLDLVLRNISCDIKGGEKVGIVGRTGAGKSSLTLCLLRMVEAASGAIAIDGVDISRIGLHDLRSRITIIPQDPVLFGGSLRDNLDPFGHHSDAEVWEALEFAHLGETARALPGGIQHECAEGGENFSVGQRQLACLARALLRRTRVLVLDEATAAVDVETDALIQGTIRTHFHACTVLTIAHRLHTVLDCTRVMVLSSGQIVEFDSPDVLLSRKDSAFHK 1508 HSP 3 Score: 80.4925 bits (197), Expect = 2.671e-15 Identity = 66/266 (24.81%), Postives = 120/266 (45.11%), Query Frame = 2
Query: 3683 DLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI---KHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEII 4471
+L S++L RL NF ++E E + P IE F + D L++I+L + G + +VG GSGK+SL+ +L + +GGS+ + + + ++R N+ L++ ++ L L L ++ + + G+ G +LS GQRQ + LAR I + + +LD+ ++VD + I E + T +++ H S L +D+I+V+ G + E G SE++
Sbjct: 582 ELAMASVSLRRLRNFLSLE-ELDPHAVDRSPSHLRESCVSIEGGTFTWSW--DEPPILHDISLAVPRGCLLAVVGTVGSGKSSLMAALLGELNKLGGSV--------------AVKGQVAYVAQQAWIQNSLRDNVLFGRPLDETWYREVLQACALEQDLLALPAGDNTEIGEKGINLSGGQRQRVSLARAIYSKASVFLLDDPLSAVDAHVGKHIFERVIGPSGLLAGQTRVLVTHGLSFLPHVDRIVVLTAGRVSESGSYSELM 830 HSP 4 Score: 61.2326 bits (147), Expect = 1.872e-9 Identity = 46/174 (26.44%), Postives = 83/174 (47.70%), Query Frame = 2
Query: 1805 IEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKG-------------SMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELNGVDRMLC-------SGGQRQRINLARAVYQKSEIYLLDDPLSALD 2266
+E ++ S +R + +L+ I+ I GE VGIVG+ +GK+SL ++ + GA++I G ++ +PQ+P + S +DN+ + + + L+F A L G + C S GQRQ LARA+ +++ + +LD+ +A+D
Sbjct: 1277 VEFRDYSTRYREGLDLVLRNISCDIKGGEKVGIVGRTGAGKSSLTLCLLRMVEAASGAIAIDGVDISRIGLHDLRSRITIIPQDPVLFGGSLRDNLDPFGHHSDAEVWEA-----LEFAHLGETARALPGGIQHECAEGGENFSVGQRQLACLARALLRRTRVLVLDEATAAVD 1445
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007076.1 (pep scaffold:Pmarinus_7.0:GL480539:10051:22495:1 gene:ENSPMAG00000006379.1 transcript:ENSPMAT00000007076.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 283.878 bits (725), Expect = 1.351e-83 Identity = 169/528 (32.01%), Postives = 294/528 (55.68%), Query Frame = 2
Query: 2942 SYDYHATAN------YYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAIC--YRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSK 4498
S Y ++AN +Y+ +YG + G +F F+ G A+K IH +L+KVL++ + +F + + +I+N FS D+ +D +P ++ + +F ++ + V+ + P L+++P+ +Y+ + K+Y ++ + + L + SPI+ F E+L G +I+A + F E L N + + + WL +RL +G ++V +A+ + + P LVGL I+Y++ I L+ ++ + ET +++ER+ + + SE + H +WP+ G + F K L Y F LN I+ I EK+GIVGRTGSGK++L LF++V+ G++ ID+ DI + + +R + + PQ+ +FS T+R N+DP +DH L + L HL ++ G L + + G S GQRQLLCLAR +L +KI+ +DEATASVDQ+TD L+ +TI+ F+NST+L IAHR + + D D+++V+ G ++EF +++ +P S+
Sbjct: 5 SPPYRSSANGSDPVQFYLSVYGALAAGNTVFTLLRAFLFAYGGVCAAKNIHVTLLHKVLQAPVSFFDATPTGRIMNRFSSDLFTVDDSLPFIMNIFMAQLFGLVGAIVVMCYGLPWMALVLLPLAGVYYCVQKYYRFTSRELKRLGSVTLSPIYSHFAESLSGLAIIKAFRATDRFTRENEARLELNQRCQFAAVAVMHWLDVRLQMMGVVIVVSLAALAVLEHHLRGVDPGLVGLAIAYALGINGRLSGLVSSFTQTETQMVSVERVQEYRGIASE-EAHRHPTHVSPDWPQGGALTFDKVFLTYRPGLPFALNGISFCINSWEKVGIVGRTGSGKSTLFSVLFRIVDVQHGAIYIDNQDISKLALKQLRSNLAIIPQDPFLFSDTVRNNLDPKGSYQDHELWEVLEKCHLKSFVLD-QGGLQAEVAERGRDFSCGQRQLLCLARAMLFKAKILCIDEATASVDQDTDVLLQKTIRSEFVNSTVLTIAHRPNTILDSDRVLVLQGGRVLEFASPHDLLQDPRSALSR 530 HSP 2 Score: 58.151 bits (139), Expect = 1.104e-8 Identity = 52/223 (23.32%), Postives = 103/223 (46.19%), Query Frame = 2
Query: 1826 FSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSI-------------KGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLD---FDLRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISND 2446
++R L I+ IN E VGIVG+ SGK++L + + + + GA+ I + +++ +PQ+P++ + ++N+ Y +++ V+ C L D QA+ C GQRQ + LARA+ K++I +D+ +++D + +K I + N+T L + N + D+++ L + G + + ++ D
Sbjct: 307 LTYRPGLPFALNGISFCINSWEKVGIVGRTGSGKSTLFSVLFRIVDVQHGAIYIDNQDISKLALKQLRSNLAIIPQDPFLFSDTVRNNLDPKGSYQDHELWEVLEKCHLKSFVLDQGGLQAEVAERGRDFSC--GQRQLLCLARAMLFKAKILCIDEATASVDQDT-DVLLQKTIRSE--FVNSTVLTIAHRPNTILDSDRVLVL-QGGRVLEFASPHDLLQD 523
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006454.1 (pep scaffold:Pmarinus_7.0:GL483531:32:7621:1 gene:ENSPMAG00000005809.1 transcript:ENSPMAT00000006454.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 260.766 bits (665), Expect = 4.905e-76 Identity = 172/486 (35.39%), Postives = 270/486 (55.56%), Query Frame = 2
Query: 3047 GNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNF-NAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSG-KTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFS 4495
G AS +HD + KVL+S + F + + ++LN FS+D+D +D +P I + V+ VI FP FLL ++P+ +L+ II K + + L S SP +LQG P I A + F +LL+ N L++ + WL++RLD + L+ + +M + ++ + GL ISY+I + + I + E ++ER+ ++ A+E E D +EWP+ G + F+ ++Y E L + I+ E +GIVGRTGSG K+SL LF+LVE GGS+ ID + I DI + D+R +++ PQE +F GTIR N+DP D + +AL +H+ + + L + +NG + SVG+RQLLC+AR ILR+SKI++LDEATA++D ETD LI ETI+ F + T+L IAHR + + D+I+VMD+G+++EF S ++ N F+
Sbjct: 3 GTLRASSRLHDSLFLKVLRSSMTVFDTTPTGRLLNRFSRDMDEVDVRMPFQAELFIQNVILVLFCLGVIAAVFPWFLLAVIPLCVLFLIINKISRVFIRELKRLDNISHSPFMSHVAASLQGLPTIHAYSKSDEFLHRYQELLDTNQACLFLFSCAVRWLAVRLDIISVALITTTALMMVLMHGQIPAAYAGLAISYAIQLTGTFQFTIRLASETEARFTSVERIQHYIEALEEEAPDHVPEKPLAAEWPQHGSVSFQDVEMRYREGLPLVLKRVTANIKPRENVGIVGRTGSGCKSSLGVCLFRLVELCGGSISIDGVPIGDIGLGDLRSRLSIIPQEPVLFIGTIRTNLDPLGLYTDEQIWEALERTHMKDNIGQLPQKLETEVVENGENFSVGERQLLCVARAILRHSKILLLDEATAAIDTETDTLIQETIRRAFGDCTMLTIAHRLNTVLSCDRIMVMDQGQVVEFDSPSTLLENRASRFA 488 HSP 2 Score: 58.151 bits (139), Expect = 1.248e-8 Identity = 56/244 (22.95%), Postives = 104/244 (42.62%), Query Frame = 2
Query: 1805 IEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAII---GEMCILDGAVSIKG-------------SMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELNGVDRML----------CSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDF 2458
+ ++ +R +LKR+ +I E VGIVG+ SG S L + E+C G++SI G +S +PQ P + + + N+ Y + + RT+ D + + + L S G+RQ + +ARA+ + S+I LLD+ +A+D + E + G + T L + +N + D+I+ +D+ +++ + + N A F
Sbjct: 257 VSFQDVEMRYREGLPLVLKRVTANIKPRENVGIVGRTGSGCKSSLGVCLFRLVELC--GGSISIDGVPIGDIGLGDLRSRLSIIPQEPVLFIGTIRTNLDPLGLYTDEQIWEALE--------RTHMKDNIGQLPQKLETEVVENGENFSVGERQLLCVARAILRHSKILLLDEATAAIDTETDTLIQETIRRAFG---DCTMLTIAHRLNTVLSCDRIMVMDQGQVVEFDSPSTLLENRASRF 487
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001536.1 (pep scaffold:Pmarinus_7.0:GL479104:2125:31869:1 gene:ENSPMAG00000001392.1 transcript:ENSPMAT00000001536.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 260.381 bits (664), Expect = 1.058e-75 Identity = 160/514 (31.13%), Postives = 299/514 (58.17%), Query Frame = 2
Query: 2972 YMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLN-DNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAIC--YRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDK--EYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFS 4495
Y +++GL+ I LT ++ +H+ ML +++ + ++YF + ILN FS D + +D IP L ++ +++ +I + P+FL+ +VP+ + Y+ I K++ ++ Q L + P+F F+ET++G IRA + + F+ L +L + +N +L++ + N WL +RLD++G +V + + +I + N L+ + VGL ++Y++ + + LNW++ D+E A++R++N +E+E D PD+ WP+ G+I+ ++ +++Y K L ++N I+ +K+GI GRTGSGK+SL + F++V+ G ++ID+IDI I + +R +++ Q+ +FSG+IR N+DP D VL +AL+++ L ++++ G L +NG + SVGQRQL CLAR +R + I ++DEATAS+D T+ ++ + + F N T++IIAHR + D ++V+ RG ++E+ S ++ + + + S
Sbjct: 2 YPMVFGLLCCSGIALCFITSLTVEWTGLKTARNVHNNMLKRIVLAPMRYFDTTPLGHILNRFSADTNIMDQQIPTTLESLMRSALLCLSALGIIAYVTPIFLIALVPLAIAYYFIQKYFRVASRDLQELDDSTQLPLFSHFSETVEGITTIRAFRHEVRFRQRLLELTDANNISYLFL-SAANRWLEVRLDYIGACIVLIASVASITDSWNNTLSSARVGLCLTYALMVSNYLNWVVRNLADIEVQMGAIKRVNNLLQIETESYDGLLSQAQVPDN-WPQSGEIKIEELSVRYDSTLKPVLKHVNAHIQPSQKVGICGRTGSGKSSLSLAFFRMVDTFEGRIIIDNIDIAKIPLHTLRSRLSIILQDPILFSGSIRFNLDPEAACGDGVLWEALDIAQLKHVVKALPGGLDAMVTENGENFSVGQRQLFCLARAFVRKTSIFIMDEATASIDMATESILQKVVMTAFANRTVVIIAHRVHTILTADLVMVLKRGSVLEYDTPSTLLAHDSMFAS 513 HSP 2 Score: 62.3882 bits (150), Expect = 6.381e-10 Identity = 56/245 (22.86%), Postives = 113/245 (46.12%), Query Frame = 2
Query: 1808 EIKNGSFSWRSDS--EPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAV-------------SIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELNGVDRMLC------SGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEK 2479
EIK S R DS +P+LK +N I + VGI G+ SGK+SL A + +G + +++ +S + Q+P + S + N+ + + I L ++ G+D M+ S GQRQ LARA +K+ I+++D+ +++D + + + +KV+ AN T + + ++ + D ++ L ++Y + +++D++ ++++K
Sbjct: 282 EIKIEELSVRYDSTLKPVLKHVNAHIQPSQKVGICGRTGSGKSSLSLAFFRMVDTFEGRIIIDNIDIAKIPLHTLRSRLSIILQDPILFSGSIRFNLDPEAACGDGVLWEALDIAQLKHVVKALPG----GLDAMVTENGENFSVGQRQLFCLARAFVRKTSIFIMDEATASID-MATESILQKVVMTA--FANRTVVIIAHRVHTILTADLVMVLKRGSVLEYDTPSTLLAHDSMFASFVRADK 519
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Match: ABCC8 (ATP binding cassette subfamily C member 8 [Source:HGNC Symbol;Acc:HGNC:59]) HSP 1 Score: 252.677 bits (644), Expect = 4.802e-68 Identity = 152/485 (31.34%), Postives = 290/485 (59.79%), Query Frame = 2
Query: 3056 NASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLN-DNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAIC--YRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSE-WPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFS 4495
A++ +H +L +++++ L++F + ILN FS D+ ID LIP++ ++ +++ VI + P+FL+ +VP+ L+++ I K + ++ Q L + P+ ET+ G IRA + + F+ +F+L++ +N FL++ + N WL +R+D++G +V + + +I + + L LVGL ++Y++ + LNW++ D+E A++R++N +E E +++ H E WP G+I+ + + +Y K L N++ VI+ G+K+GI GRTGSGK+SL +LF++++ GS+ IDD+DI I ++ +R +++ Q+ +FSG+IR N+DP D +L AL ++ L ++++ G L + G + S+GQRQL CLAR +R + I+++DEATA++D T++++ + + F + T+++IAHR + + D D ++V+++G + E + ++ NP+ FS
Sbjct: 1088 KAARGLHKRLLGRIVRAPLRFFDTTPLGSILNRFSADLHMIDQLIPSSTESLVRSSLFSLSAVSVIAYVTPIFLVALVPLALVHYFIQKHFRIASKDLQELDENTKLPLLLHIMETVDGIATIRAFRHESQFRQRIFELIDANNVPFLFL-SAANRWLEVRMDYIGASIVLATAMASITRSFYSGLDSGLVGLGLTYALLVSIYLNWVVRNLADIEVQLQAIKRVNNLMKVEIEDDERSPELHAVPEDWPHRGEIKINRLSARYDASLKPALKNLSSVIQPGQKVGICGRTGSGKSSLSLALFRMLDIFDGSITIDDVDISKIPLSLLRSRLSIILQDPVLFSGSIRFNLDPEARSTDSMLWDALEIAQLKCVVKALPGGLDATVREGGENFSLGQRQLFCLARAFVRQTAILIMDEATAALDMATEKILQKVVMTAFADRTVVMIAHRVANILDADVVLVLNQGLLEENDSPANLLANPDTIFS 1571 HSP 2 Score: 201.06 bits (510), Expect = 3.931e-52 Identity = 167/713 (23.42%), Postives = 321/713 (45.02%), Query Frame = 2
Query: 635 LDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFK-RKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPF----ILKYL---------------LKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEA--KSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIF-PNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFL-------------IENKTK-----------------------NYFSSCQDIRS----------VIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAV--------------------------SIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRT-NQADELN-GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTR--LFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSE 2476
L + Y W N I T + + D+ + R L++ + + ++ R V L +++F FG +I+S + +F+ P I+ +L + FIS+ E L + L++ + +L ++ T ++ R+A+ + +Y K ++++ + + T+ I N+++ D+++++ + + + P +II+ + L++ +G A IG V+ PL + L Q +E RIK +E+++ +K++KLY+WE +F + R KE+ + ++ + + + +P++ ++ TYV++ P+ ++ F S+ L ++L +P+ +L + A+ +S+++++ FL +E + K + F QD R I++ G F+W S +L INI I G+L +VG+I GK+SLL+A +GEM ++ G+V +GS++Y Q PWI + ++NI + E YK VI C L D+ Q D G + S GQRQRI++ARA+YQ + + LDDP +ALD ++ + I G+L N TR + VT + +L + D II + ++G+++ G + +I + ++ E
Sbjct: 224 LSQATYWWLSNLISLAQTRLIDLE---DIGKLPIGMRALSNYILLQKSFQEHKRECEARQEVVPSLWRSVFRTFGRPIIVSSVLRYMADLLAFTGPLCIYGIVHHLNNDEQQLKPQVRALGVYFISSREF-LANAYVLSVLLFFSLVLQRTLLQASYYKAIETGIKFRAAVQTMIYDKILHLSTSSVSRGKMTSRYISNVVTVDSNQLMWFLFLCPNLWALPVQIIVGVSLLYSLLGVSALIGAAVIALLAPLQYCIATKLARAQKLTLEHSSSRIKQTSELVHGIKLLKLYAWEQVFCSTVEETRSKELRSLSTFAIYTALSTFMNAAIPITAVMATFVTYVHLSSPDITLSPAVAFASLALFHILVTPLFLLSTVVRFAVKALISMQKLTEFLATSEIGDEPNTLDVEPRPKKSSNADVVQMMAVNRKQPQKPVWDDFEPPQDWRQFEFTDGSEDFAIKVTGGVFTWASSEPSLLTDINICIPHGQLTMVVGQIGCGKSSLLSATLGEMHLVSGSVYWNSSPRQQSVNTKNNRQERRASTFCRRRGSVAYAAQKPWILNSNVQENITFGSPFNEERYKAVINTCSLQPDIDILPQGDRTQIGEKGINLSAGQRQRISVARALYQHTNVVFLDDPFTALDIHLSDHLMHSGIL--GLLHNDTRTVVLVTHKLQYLTHADWIIAM-KDGTVQREGTLKDIQTSDPELYEMWKE 929 HSP 3 Score: 64.6994 bits (156), Expect = 1.824e-10 Identity = 55/219 (25.11%), Postives = 104/219 (47.49%), Query Frame = 2
Query: 1808 EIKNGSFSWRSDS--EPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSI-------------KGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELNGVDRMLCSG------GQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDEN 2401
EIK S R D+ +P LK ++ I G+ VGI G+ SGK+SL A+ + I DG+++I + +S + Q+P + S + N+ + ++ + + I L ++ G+D + G GQRQ LARA +++ I ++D+ +ALD + +K+ +KV+ A+ T + + + + D ++ L++
Sbjct: 1340 EIKINRLSARYDASLKPALKNLSSVIQPGQKVGICGRTGSGKSSLSLALFRMLDIFDGSITIDDVDISKIPLSLLRSRLSIILQDPVLFSGSIRFNLDPEARSTDSMLWDALEIAQLKCVVKALPG----GLDATVREGGENFSLGQRQLFCLARAFVRQTAILIMDEATAALD-MATEKILQKVVMTA--FADRTVVMIAHRVANILDADVVLVLNQG 1551 HSP 4 Score: 63.929 bits (154), Expect = 3.130e-10 Identity = 57/232 (24.57%), Postives = 106/232 (45.69%), Query Frame = 2
Query: 3854 LNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXX-------------XXXXXTMFPQESTIFSGTIRQNI---DPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVD-QETDRLIMETIKHRFINS--TILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEI-INNPNGY 4489
L +IN+ I HG+ +VG+ G GK+SL+ + + + GS+ + + T R ++ Q+ I + +++NI PFN + K +N L P ++ + G+ G +LS GQRQ + +AR + +++ ++ LD+ ++D +D L+ I N T++++ H+ L D II M G + G +I ++P Y
Sbjct: 696 LTDINICIPHGQLTMVVGQIGCGKSSLLSATLGEMHLVSGSVYWNSSPRQQSVNTKNNRQERRASTFCRRRGSVAYAAQKPWILNSNVQENITFGSPFN---EERYKAVINTCSLQPDIDILPQGDRTQIGEKGINLSAGQRQRISVARALYQHTNVVFLDDPFTALDIHLSDHLMHSGILGLLHNDTRTVVLVTHKLQYLTHADWIIAMKDGTVQREGTLKDIQTSDPELY 924
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: BPT1 (ABC type transmembrane transporter of MRP/CFTR family; found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p [Source:SGD;Acc:S000003938]) HSP 1 Score: 498.819 bits (1283), Expect = 8.842e-151 Identity = 402/1379 (29.15%), Postives = 685/1379 (49.67%), Query Frame = 2
Query: 614 SRILFMWLDRYIYSWFQNG-IKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPET----PLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMG-TFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNR-EKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYF------SSCQDIRSVIEIKNGSFSW---------------RSDSEPILKRINISIN--------KGELVGIVGKIASGKTSLLNAIIGEMCILDGA--------VSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRT-NQADE-LNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKV-ISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSI---KYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYH--------QINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILT-ILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSL-GNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRN---KLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESI-------------NGN----LHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNG-YFSKCK 4504
S I F+W+++ I ++N IK + + D+N + ++ K N+ + + +N +S +W +A++ FG + ++ + S +P L+ + ++ PET P G +A++ + ++S N + L +R ++AS VY KS+ + ++ + +I+NLMS D +I + +I +P +II++ L+ +G A IG LV M P+N+ ++ +M++KD RIK +TE+LN +K IKLY+WE ++ R + E+ R I + S ++ W+ +P+ V + + ++F + ++ F S+ L N+L S + +P I + VS++R+ FL+ ++ + F S+ + IE+ N +F W R+D E I+ I++ +G+LV +VG++ +GK++ L AI+G++ + G+ + S++Y Q WI S ++NI+ K+ ++ Y I+ C L DL+ DE L G + SGGQ+ R++LARAVY +++IYLLDD LSA+DA V++ + E V I +L N T + T ++ L + ++I+ ENG I Y DV N N+ K+ E F P ES + + + K+ + + + + N R+ L + ++ + TE+ V K Y Y A G L + F F ILT + + ++WL K S+ N + ++ +Y LIG F + L + SK +H+ M V++S + +F + +I+N FS D+D +DS + S I + + ++ + P FL+ + + ++Y FY+ + + + L S SPI +E+L G +I A + F + ++ + N F++ N WLS+RL +G +V + I+A+ N +L+ +VGL +SYS+++ L W++ V +ETN +++ER+ + + E PD WP G IEFK ++ KY E+ LNNIN+ IE EK+GIVGRTG+GK++L +LF+++EP G ++ID IDI DI + D+R + + PQ++ F GT++ N+DPFN + LK+A+ +HL P LE + +GN L +NGS+LSVGQRQLLCLAR +L SKI+VLDEATASVD ETD++I +TI+ F + TIL IAHR + D DKIIV+D+G + EF S+++++ ++S C+
Sbjct: 223 SYITFIWMNKLIVETYRNKKIKDPNQLPLP---PVDLNIKSISKEF------KANWELE--KWLNRNS-LW---RAIWKSFGRTISVAMLYETTSDLLSVVQPQFLRIFIDGLN-PETSSKYPPLNGVFIALTLFVISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRFFENAQTIIGAPIQIIVVLTSLYWLLGK-AVIGGLVTMAIMMPINAFLSRKVKKLSKTQMKYKDMRIKTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIYFAWNCVPLMVTCSTFGLF-SLFSDSPLSPAIVFPSLSLFNILNSAIYSVPSMINTIIETSVSMERLKSFLLSDEIDDSFIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKH-SQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLEE--FDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELELIKANSRRASLATLRPRPFVGAQLDSVKKTAQKAE-KTEVGRVKTKIYLAYIKACGVLGVVL-FFLFMILTRVFDLAENFWL-KYWSESN------------------------EKNGSNERVWMFVGVYSLIGVASAAFNNLRSIMMLLYCSIRGSKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVGYNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERFIYLNYEKIQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLMSYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINPEKRPDENWPSKGGIEFKNYSTKYRENLDPVLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDISDIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDDSNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTIRREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTSIFYSLCE 1553 HSP 2 Score: 70.0922 bits (170), Expect = 2.436e-12 Identity = 58/232 (25.00%), Postives = 107/232 (46.12%), Query Frame = 2
Query: 3833 VEDCKFCLNNIN-LVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI----KHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLYE 4513
+ + L NI+ + G+ + +VGR G+GK++ ++++ + + GS D + ++ QES I + ++R+NI + + + L P L+ + G+ G SLS GQ+ L LAR + + I +LD+ ++VD E + I+E + N TI++ + S L+ I ++ GEI+E G +++N N KL E
Sbjct: 647 IGSSQIALKNIDHFEAKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGS-----RDSIPPKLIIRSSSVAYCSQESWIMNASVRENILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIYLLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYEDVMNRKNNTSKLKKLLE 873
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YBT1 (Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates release of lumenal Ca2+ stores; similar to mammalian bile transporters; YBT1 has a paralog, VMR1, that arose from the whole genome duplication [Source:SGD;Acc:S000003971]) HSP 1 Score: 485.337 bits (1248), Expect = 2.675e-145 Identity = 388/1398 (27.75%), Postives = 676/1398 (48.35%), Query Frame = 2
Query: 584 PCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFI----SAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSK-------------------------SININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRS-VIEIKNGSFSWRSDSEPI-LKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKG----------------SMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATAN-----------------YYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHF-QFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESE-FNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHL--------GPWLESING-------------NLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKT-SEIINNPNGYFSKCK 4504
P PE +SI I + WLD +++ + IK + + + Q + F+ + +K K + S + + + + GS + SF +LK +L+++ SAP +F T+ + IL +I Q ++++S I S +Y+K SIN + E+ S+ IINLM+ D K+ Y + + ++ A L+ +G A +GVL+++ PLN ++ Q + + D RI+ + E +++IK +SWE F K I+ RE E++L+ + S+ + + +W P V Y+ + V+T F ++ L +LR P+ L ++ + VSL RV FL EN TK Y D +N + SW D++ LK +NI G+L ++G SGKTSLL A++GEM +L+G V + S++Y Q W+ + K+NI+ + + E YK V+ C L D +A +L G + SGGQ+QR++LARA+Y + LLDD LSA+D+ A +++ I+ ++ + T + V+ NI +++ L E+G +K GD ++ + F + + KS A + ++ ++ + N + + ++ + S + ++K L + D YK Y K F + S+F I +L + S+W+ S N++ I ++ +H+ D+ ++ YY+++Y +IGF Q + + + NAS+ I + +LNKVL SK+++F + + +I+N FSKDI+ ID + + + + +++ +I P FL + + + +LY+ + FY+ + + + S SPI++ F+ETL G IRA + F Q L K+ +N F Y+ V N WL+ R+D +G++++FG+ + + N L + G++++Y+I + W++ Y ++E N ++ER+ + +E E +N+ + + P +WP+ GKIE +L+Y + + N++ ++ KIGIVGRTG+GK++++ +LF+ +EP G + ID+IDI +D+ +RR+IT+ PQ+ T+FSGTI+ N+DP++ D + +AL +L G E+ N +L + + GS+LS GQRQL+CLAR +LR+ KII+LDEATAS+D +D I ETI+ F STIL IAHR + D DKI+VMD GE+ E+ S ++N + ++S C+
Sbjct: 278 PSPEPVTSIAGFICWAWLDSFVWKAHKVSIKVKDIWGLMMQDYSFFVVKKFRYFVDHKVKRKRIFSLNLF----FFFSNYLVLQCFWAFLGS-------------VLSFIPTVLLKRILEYVEDQSSAPSNLAWFYVTV---MFVGRILVAICQAQALFFGRRVCIRMKSIIISEIYTKALRRKISTNKTKPSNEDPQEINDQKSINGDEESTSSANLGAIINLMAIDAFKVSEICGYLHSFLEAFVMTVVALALLYRLLGFAAIVGVLIIVAMLPLNYKLAKYIGDLQKKNLAVTDNRIQKLNEAFQAIRIIKYFSWEENFEKDINTIRENELSLLLMRSIVWSISSFLWFVTPTIVTAASFAYYIYV-QGEVLTTPVAFTALSLFTLLRDPLDRLSDMLSFVVQSKVSLDRVQDFLNENDTKKYDQLTIDPNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAVVEACGLKRDFEILKAGDLTEIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITG-PLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQKGL-FGEDELVKSSILSRANSSANLAAKSSTSLSNLPAVKEQQVSVNNNSSHFEAKKLQKS-LRTEAERTEDGKLIKEETKEEGVVGLDV------YKWYLKIFGGWKIVSFLASLFL--IAQLLYIGQSWWVRAWASH-NVIAKIIPRAQRAIAFISKKASHLI---DWRGSSQISMASAENQPSSGHSTMYYLVLYLIIGFAQALLGAGKTILNFVAGINASRKIFNMILNKVLHSKIRFFDATPTGRIMNRFSKDIEAIDQELTPYIQGAFYSLIECLSTVILITFITPQFLSVAIVVSILYYFVGYFYMAGSRELKRFESISRSPIYQHFSETLVGVTTIRAFGDEGRFMQENLHKIDENNKPFFYLW-VANRWLAFRIDMIGSLVIFGAGLFILFNINNLDSGMAGISLTYAISFTEGALWLVRLYSEVEMNMNSVERVKEYMEIEQEPYNEHKEI--PPPQWPQDGKIEVNDLSLRYAPNLPRVIKNVSFSVDAQSKIGIVGRTGAGKSTIITALFRFLEPETGHIKIDNIDISGVDLQRLRRSITIIPQDPTLFSGTIKTNLDPYDEFSDRQIFEALKRVNLISEEQLQQGATRETSNEASSTNSENVNKFLDLSSEISEGGSNLSQGQRQLMCLARSLLRSPKIILLDEATASIDYSSDAKIQETIRKEFQGSTILTIAHRLRSVIDYDKILVMDAGEVKEYDHPYSLLLNKQSAFYSMCE 1636 HSP 2 Score: 60.077 bits (144), Expect = 2.846e-9 Identity = 58/250 (23.20%), Postives = 124/250 (49.60%), Query Frame = 2
Query: 3788 PRFGKIEFKKFNLKYVEDCK-FCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFP---QESTIFSGTIRQNI---DPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMET--IKHRFINSTILIIAHRTS-GLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKL 4507
P + F+ + + +D + F L ++N+ + G+ ++G TGSGKTSL+ +L + + G +++ ++ R I D Q + + + T++ NI PFN + +A L L++ G+L + G+ G +LS GQ+Q + LAR + N++ ++LD+ ++VD T I + + T ++++H + L + + +++++ G + + G +++ G F + +L
Sbjct: 689 PNGNRFAFENSTISWDKDNQDFKLKDLNIEFKTGKLNVVIGPTGSGKTSLLMALLGEMYLLNGKVVVPALEPRQELIVDANGTTNSIAYCSQAAWLLNDTVKNNILFNSPFNEARYKAVVEACGLKRDFEILKA--GDLT-EIGEKGITLSGGQKQRVSLARALYSNARHVLLDDCLSAVDSHTASWIYDNCITGPLMEDRTCILVSHNIALTLRNAELVVLLEDGRVKDQGDPIDMLQ--KGLFGEDEL 933
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: VMR1 (Vacuolar membrane protein; involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions; VMR1 has a paralog, YBT1, that arose from the whole genome duplication [Source:SGD;Acc:S000001027]) HSP 1 Score: 466.077 bits (1198), Expect = 8.466e-139 Identity = 384/1375 (27.93%), Postives = 673/1375 (48.95%), Query Frame = 2
Query: 572 ENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAP---ETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSI--------NINNEAKSTFTN-AEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFS-SCQDIRSVIEIKNGSFSWRSDSEPI----LKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAV----------------SIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRI---HKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILT-ILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSE--------WPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQAL---NLSHLGPWLESING------------NLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNG-YFSKCK 4504
++ +P E SSI S I + W+ +I+ +N IK + + + + + F R+ N H + LT ALF F + L+I ++ + I + ++K L+ + P + + + I I + +I + ++ L++R+ + +Y+K + ++++ S N IINL+S D+ K+ Y ++ + + II++ LFN +G A G+ +++ FPLN + + L +Q + ++ D+RI + E L N++++K ++WE I R+KE+ + SL V + +W P +++ + + + + A F ++ L +L++P+ L ++ VSLKR+S FL + T+ Y + ++ IE KN + +W + + L +NI G+L I+G SGK++LL ++GE+ ++ G++ + S +Y Q+ W+ + K+NII Y E+ Y VI C L DL A +L G + SGGQ+QRI+LARAVY ++ LLDD LSA+D+ A ++E I+ ++ N T + VT N++ + ENG +K G ++ +++S+ F + + + S+ + + +N+ R+ K I+ IN F+ + + E + I YK Y K+F G + ++FA I IL + S+W+ +D N+ N + MT S A YY+ +Y LIG Q + F + L AS+ I + +L+ VL +++++F + +I+N FSKDI+ +D + L I C+ Q + F+I P FL + V + +LYF + K+YL ++ + + L + SPIF+ F+ETL G IRA ++ F E ++ N + + +V W S R+D +G +V S + + L G++++Y+I D W++ Y E N ++ERL ++++E E YL H + WP+ G+IE + +L+Y + + N++ ++ KIGIVGRTG+GK++++ +LF+L+EPI G + ID DI ID+ +RR+IT+ PQ+ +F+GTI+ N+DP++ ++ + +AL NL + E +N NLH + + G +LS G+RQLL +AR +LR KII+LDEAT+S+D ++D LI I+ F STIL IAHR + D D+IIVMD GE+ E+ + SE++ + G ++S C+
Sbjct: 262 DHTSPSREHISSILSCITWSWITNFIWEAQKNTIKLKDIWGLSMEDYSIFILKGFTRR---------NKHINN------------LTLALFESFKTYLLIGMLWVLVNSIVNLLPTILMKRFLEIVDNPNRSSSCMNLAWLYIIGMFICRLTLAICNSQGQFVSDKICLRIRAILIGEIYAKGLRRRLFTSPKTSSDSDSISANLGTIINLISIDSFKVSELANYLYVTVQAVIMIIVVVGLLFNFLGVSAFAGISIILVMFPLNFLLANLLGKFQKQTLKCTDQRISKLNECLQNIRIVKYFAWERNIINEIKSIRQKELRSLLKKSLVWSVTSFLWFVTP-TLVTGVTFAICTFVQHEDLNAPLAFTTLSLFTLLKTPLDQLSNMLSFINQSKVSLKRISDFLRMDDTEKYNQLTISPDKNKIEFKNATLTWNENDSDMNAFKLCGLNIKFQIGKLNLILGSTGSGKSALLLGLLGELNLISGSIIVPSLEPKHDLIPDCEGLTNSFAYCSQSAWLLNDTVKNNIIFDNFYNEDRYNKVIDACGLKRDLEILPAGDLTEIGEKGITLSGGQKQRISLARAVYSSAKHVLLDDCLSAVDSHTAVWIYENCITG-PLMKNRTCILVTHNVSLTLRNAHFAIVLENGKVKNQGTIT----------ELQSKGLFKEKYVQ------LSSRDSINEKNANRLKAPRKNDSQKIEPVTENINFDANFV-------------NDGQLIEEEEKSNGAISPDVYKWYLKFF---GGFKALTALFALYITAQILFISQSWWIRHWVNDTNV-----RINAPGFAMDTLPLKGMTDSSKNKHNAFYYLTVYFLIGIIQAMLGGFKTMMTFLSGMRASRKIFNNLLDLVLHAQIRFFDVTPVGRIMNRFSKDIEGVDQELIPYLEVTIFCLIQCASIIFLITVITPRFLTVAVIVFVLYFFVGKWYLTASRELKRLDSITKSPIFQHFSETLVGVCTIRAFGDERRFILENMNKIDQNNRAFFYLSVTVKWFSFRVDMIGAFIVLASGSFILLNIANIDSGLAGISLTYAILFTDGALWLVRLYSTFEMNMNSVERLKEYSSIEQE----NYLGHDEGRILLLNEPSWPKDGEIEIENLSLRYAPNLPPVIRNVSFKVDPQSKIGIVGRTGAGKSTIITALFRLLEPITGCIKIDGQDISKIDLVTLRRSITIIPQDPILFAGTIKSNVDPYDEYDEKKIFKALSQVNLISSHEFEEVLNSEERFNSTHNKFLNLHTEIAEGGLNLSQGERQLLFIARSLLREPKIILLDEATSSIDYDSDHLIQGIIRSEFNKSTILTIAHRLRSVIDYDRIIVMDAGEVKEYDRPSELLKDERGIFYSMCR 1572
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YOR1 (Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter mediates export of many different organic anions including oligomycin; homolog of human cystic fibrosis transmembrane receptor (CFTR) [Source:SGD;Acc:S000003513]) HSP 1 Score: 313.923 bits (803), Expect = 1.086e-87 Identity = 256/904 (28.32%), Postives = 429/904 (47.46%), Query Frame = 2
Query: 1859 KRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEK-----SFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIK------SVSYKAYFKYFLARGSLQLFCSIFAFGIL----TILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRN--KLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNA---MESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQAL---------NLSHLGPWLESING------NLHFDCG--DNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEF 4450
K +N I KGE + I G I +GK+SLLNA+ G M DG V + G + + PWI+ S +DNII + + Y V+R+C L DL A ++ G + SGGQ+ RINLAR+VY+K +IYL DD LSA+D+ V + + ++ ++ G+LAN TR+ T ++ + ++I L G + +D +K +++ FS ++NS + + A + + Q+ + + + + + S D T K S+S K Y +Y A F ++ + IL T + SS WL + T + + ++YM +Y F IF + ASK ++ + ++L + + Y + +ILN F+KD D++D+ + +L + + ++ + + P F + I + +++ +I Y S + + L S ++ NE L G I+A + ++ F + L+N + Y+ VL W+ + LD + + F +I +C ++ + VG+ ++Y + + LLN ++ E + + ERL + +E+ + E P WP G+I F+ + Y L N+NL I+ GEKIGI GRTG+GK++++ +L++L E G +LID++DI + + D+RR + + PQ+ +F GTIR+N+DPFN D L AL +L + NG H D + GS+ S+G+RQLL L R ++R SKI++LDEAT+SVD ETD I I F + TIL IAHR + + D+I+V+++GE+ EF
Sbjct: 605 KDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDL-LMCGYPWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLT--GMLANKTRILATHQLSLIERASRVIVL---------GTDGQVDIGTVDELKARNQTLINLLQFS-------------------SQNSEKEDEEQEAVVAGELGQLKYESEVKELTELKKKATEMSQTANSGKIVADGHTSSKEERAVNSISLKIYREYIKAAVGKWGFIALPLYAILVVGTTFCSLFSSVWLS----------------------------YWTENKFKNRPPSFYMGLYSFFVFAAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHTPMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQFANIVGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGYLVVVLQRWVGIFLDMVA--IAFALIITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMT--PPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRLKTIVNYDRILVLEKGEVAEF 1445 HSP 2 Score: 162.155 bits (409), Expect = 2.116e-40 Identity = 172/695 (24.75%), Postives = 304/695 (43.74%), Query Frame = 2
Query: 590 PEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTL-KSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISW-----CAIVFHIIFSFS---RPFILKYLLKFISAPETPLFF------GFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLP-MSVLLTMLWTY-VNIF---PNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFL----------IENKTKNYFSSCQDIRSVIEIKNGSFSWR----SDSEPILK-------------------RINISINKGELVGIVGKIASGKTSL----------LNAII--GEMCILDGAV---------SIKGSMSYVPQN------------PWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSI 2410
P +++I S + F W+ + ++ I+ F + + + +F++ + K++ Y + R P V K H L+ ++ +IVF I+ + + P I K L++F+ E +F G AI + ++ +T N FH + T +Q +S + A K N +N A+ F N ++ + ++TD +I A+++ + P + + L +G +A +G+ + G F ++ A + ++ + D R+ M EVLNN+K+IK Y+WE + K I R KE++ +R + L + + +LP ++ L+T L Y VN P + F S+ L +L M LP I ++ + L R+ L IE K F D + +++ + SF W +D+ K + + S NK + + + K G L LN I GE ++ G + ++ GSM PWI+ S +DNII + + Y V+R+C L DL A ++ G + SGGQ+ RINLAR+VY+K +IYL DD LSA+D+ V + + ++ ++ G+LAN TR+ T ++ + ++I L +G +
Sbjct: 109 PLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLYDDFEKNMIYYFEKTRKKY--RKRHPEATEEEVMENAKLPKHTVLRALLFTFKKQYFMSIVFAILANCTSGFNPMITKRLIEFVE--EKAIFHSMHVNKGIGYAIGACLMMFVNGLTFNHFFHTSQLTGVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAICIVLLIVNLGPIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYYTWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTFLAMYKVNKGGRQPGNI------FASLSLFQVLSLQMFFLPIAIGTGIDMIIGLGRLQSLLEAPEDDPNQMIEMKPSPGF----DPKLALKMTHCSFEWEDYELNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLDNMLKDRDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMCGYPWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLT--GMLANKTRILATHQLSLIERASRVIVLGTDGQV 787 HSP 3 Score: 65.4698 bits (158), Expect = 7.399e-11 Identity = 107/488 (21.93%), Postives = 211/488 (43.24%), Query Frame = 2
Query: 1151 AEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTF-PLNSIAMSWL--------QHYQTEEMEWKDKRIKA---------MTEVLNNMKVIKLYSWESLFFK----IISRNREKEVNLIRLISLCSGVVNIIWDTLPMS-VLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSP--MAVLPYGITIAMNGYVSLKRVSLFLIE-----NKTKNYFSSCQDIRSVIEI--KNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAI-------IGEMCILD------GAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIEND-YKNVIR---ICDLDF-DLRTNQADELNGVDRMLC---------------SGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYY 2419
I+N + DTD + + S +++S F I +GV V+ + P +IA+ +L HYQ+ E K R++A + EVL M IK Y + F +I++ E L+ + V I D + ++ L+ L FP A V V+L +L+ P + + +T N S +R+ + E + K + + S+ EI +N F++R +LK +N++I GE +GI G+ +GK+++++A+ G++ I + G ++ ++ +PQ+P + + + + N+ + +++ + ++R I D +++ + DE NG + S G+RQ + L RA+ ++S+I +LD+ S++D K+ +++ G + T L + + + D+I+ L E G + +
Sbjct: 989 GRILNRFTKDTDSLDNELTESLRLMTSQFANI---------------VGVCVMCIVYLPWFAIAIPFLLVIFVLIADHYQSSGREIK--RLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNEAGY----LVVVLQRWVGIFLDMVAIAFALIITLLCVTRAFP-----ISAASVGVLLTYVLQLPGLLNTILRAMTQTENDMNSAERLVTYATELPLEASYRKPEMTPPESWPSMGEIIFENVDFAYRPGLPIVLKNLNLNIKSGEKIGICGRTGAGKSTIMSALYRLNELTAGKILIDNVDISQLGLFDLRRKLAIIPQDPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDE-NGTHGKMHKFHLDQAVEEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFG---DCTILCIAHRLKTIVNYDRILVL-EKGEVAEF 1445 HSP 4 Score: 54.299 bits (129), Expect = 1.531e-7 Identity = 48/207 (23.19%), Postives = 92/207 (44.44%), Query Frame = 2
Query: 3860 NINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNI---DPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIM-ETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEI 4468
++N I+ GE I I G G+GK+SL+ ++ + G + + + +P I + ++R NI PFN + + + L L+ + + G+ G +LS GQ+ + LAR + + I + D+ ++VD + IM E + N T ++ H+ S +E ++IV+ ++ G E+
Sbjct: 606 DLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKV-----------EVNGDLLMCGYPW---IQNASVRDNIIFGSPFN---KEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARINLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERASRVIVLGTDGQVDIGTVDEL 795
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Match: YCF1 (Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR [Source:SGD;Acc:S000002542]) HSP 1 Score: 309.686 bits (792), Expect = 2.664e-86 Identity = 189/525 (36.00%), Postives = 312/525 (59.43%), Query Frame = 2
Query: 2945 YDYHATANYYMLIYGLIGFGQIIFACFFYLT-FSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAI--CYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESI-NGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEII-NNPNGYFSKC 4501
Y + A Y+ IY +G G + + + +ASK +H+ M N VL++ + +F + +ILN FS DI +D+L+ S+ +V + VI T F+ +I+P+ + Y ++YL ++ + + L + SPI+ F ETL G +R Q+K F +++N Y N WL+ RL+ +G+I++ G+ +++ + LT +VGL++SY++ I LNW++ V++ETN +++ER+ + ++SE + P EWP G I+F ++ +Y + L +IN+ I+ EK+GIVGRTG+GK+SL +LF+++E G+++ID+I I +I + D+R +++ PQ+S +F GT+R+NIDP N D + +AL LSHL + S+ N L + G +LSVGQRQLLCLAR +L SKI+VLDEATA+VD ETD+++ ETI+ F + TIL IAHR + + D D+IIV+D G++ EF +++ +N + ++S C
Sbjct: 982 YGSNPNAARYLAIYFALGIGSALATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHINQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAPLIVEGHRPPKEWPSQGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRTILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSLFYSLC 1506 HSP 2 Score: 280.026 bits (715), Expect = 7.068e-77 Identity = 182/662 (27.49%), Postives = 334/662 (50.45%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFIS--------------------APETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIIS--RNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRV-SLFLIENKTKNYFSSCQDIRSVIEIK-----NGSFSWRSDSE--PILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLR--TNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDA 2449
+ + P P + ++I SRI F W+ + + ++ + + + ++ + ++ + LK K+N S+ W A+ FGSK++++ H + +F++P +L+ L+KF++ + P+ GF +A + + G + + F T + ++SA+ + +Y KS+ ++NEA + +I+NLMS D K+ + ++ S PF+II+ L+ +G+ +GV++L+ PLNS M + Q +M++KD+R + ++E+LNN+K +KLY+WE + + + RN ++ NL +L V + ++ +P V +V + +T + F ++ L N+L P+ ++P + + VS+ R+ + F E + ++++ ++ + +F W+ E LK IN KG L IVGK+ SGKT+LL+ ++G++ + G ++ GS++YV Q PWI + K+NI+ +Y Y+ I+ C L DL + L G + SGGQ+ R++LARAVY +++ YLLDDPL+A+D VA+ + E V+ NG+L T++ T ++ L+ D I LD NG I G I+ DA
Sbjct: 201 HQTLTRRKPNPYDSANIFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENELKQKSN------------PSLSW---AICRTFGSKMLLAAFFKAIHDVLAFTQPQLLRILIKFVTDYNSERQDDHSSLQGFENNHPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDLTQWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKL-GCYMAVTSFQFNIVPFLVSCCTFAVFVYT-EDRALTTDLVFPALTLFNLLSFPLMIIPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAINIGDDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLD-NGEITQQGTYDEITKDA 844 HSP 3 Score: 76.2554 bits (186), Expect = 3.353e-14 Identity = 71/263 (27.00%), Postives = 123/263 (46.77%), Query Frame = 2
Query: 1718 YVSLKRVSLFLIE-NKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLL------------NAIIGEMCILD-GAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELNGVDRMLCSG------GQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISND 2446
Y LK + ++E ++ + S DI+ N S +R + + +LK INI I E VGIVG+ +GK+SL N +I + I + G ++ +S +PQ+ + + + ++NI +Y + + + L + + D G+D L G GQRQ + LARA+ S+I +LD+ +A+D V KV ++ I + T L + +N + D+II LD NG + + + +D
Sbjct: 1246 YADLKSEAPLIVEGHRPPKEWPSQGDIK----FNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSND---GLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVD-VETDKVVQETIRT--AFKDRTILTIAHRLNTIMDSDRIIVLD-NGKVAEFDSPGQLLSD 1497 HSP 4 Score: 64.6994 bits (156), Expect = 1.245e-10 Identity = 55/216 (25.46%), Postives = 98/216 (45.37%), Query Frame = 2
Query: 3845 KFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI--KHRFINSTILIIA-HRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPN 4483
K L NIN + G IVG+ GSGKT+L+ + + + G V ++ Q I +GT+++NI + + ++ + L L + G+ G SLS GQ+ L LAR + + +LD+ A+VD+ R ++E + + +++ ++A ++ S L D I ++D GEI + G EI + +
Sbjct: 643 KVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKG-------------FATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLDNGEITQQGTYDEITKDAD 845
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO41257 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4U1]) HSP 1 Score: 483.797 bits (1244), Expect = 4.546e-147 Identity = 363/1261 (28.79%), Postives = 634/1261 (50.28%), Query Frame = 2
Query: 770 NNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFF--GFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKI--VTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVL-PYGITIAMNGYVSLKRV--SLFLIENKTKNYFSSCQDIRSVIE-----IKNGSFSWRSD-SEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRIC--DLDFDLRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAF-GILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHF--QFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFS 4495
Y + RRP L +AL + FG +F +P +L YL+ + ++P+ + A + G+ + + + ++VR+A + +Y K ++++ A ++ T +INL+S D K V + +I P E+ ++ L+ +IG A GV +L+ P+ + L + + + W D+R+K M E++ M+VIK+Y+WE F K+I R+ E+ ++ G + + + T YV V+TA F V L N +R A+ P+ IT+ VSLKR +L L E ++ S +R E +K S +W + + P L ++ + G L+G++G + SGK+SLLNAI+GE+ + +G++ ++G ++Y Q W+ + + NI+ K+Y E+ Y +VI+ C D DF+L + + L G + SGGQR RI+LARAVY +IYLLDDPLSA+DA V + +F++ I L + R+ VT + FL D+I+ L + I G +S + F+ + + E + N + S R + + + + +RK+ V +S ++ S+ + + + + +Y AY + F G+ +FA + ++ + WL + + + T+ + N + + D H YY+ +Y + FG + +++ AS+ +H+ M + ++ + + +F +S +ILN FSKDI ID +P L +V+ F + ++ + P+ + +++P+ L+F +++ S+ + + + + SP+F F+ TL G IRA + F QF LF + + Y+ WL+ RL LG + + V+ ++ L+ VGL +SYSI + L + + ++E ++ER+ + ++ E +K P +WP GKI F + Y + L+N+ VI+ EK+G+VGRTG+GK+SL+ +LF+L EP G + ID I+IR + + D+R +++ PQ+ +FSGT+R+N+DPF+ D L + L+ L +E + G L + + GS+ SVGQRQL+CLAR ILR+S+I+V+DEATA+VD TD LI ETI+ +F + T+L IAHR + D D+++V+D G ++EF +++ N FS
Sbjct: 46 KRYKQEKRRPS--------LVRALINAFGKGYAALGLFPLFADGLGILQPILLGYLVTYF-VEDSPITKKEAYLYAAGVGLCGLFILLFNVPFAFMKNVYGMRVRAACTALIYKKVLHLSRTALASTTTGNLINLVSADAQKFDWVRLAPFLHYLILGPLEVGVVAVLLWYQIGPAALAGVGLLVCLAPMQVKMGNALMSLRGKAIHWMDERVKIMNEIIAGMRVIKMYTWEDSFAKLIMHLRKNELKWFLRMAYIQGAFASFFFSSAGLIYFTTFLVYV--LTGEVLTAAKVFTCVSLFNSVRIVCALFFPFAITLFNESRVSLKRFEEALLLDEMHSEGLVKST--LRPKAEECGVFVKKASATWNKEIAIPTLDGLSFDVPSGCLLGVIGAVGSGKSSLLNAILGELPLSEGSIRVQGRVAYASQQAWVYNSTLRHNILFGKEYDEHRYNDVIKACALDKDFELLSEGDETLVGERGVSLSGGQRARISLARAVYADGDIYLLDDPLSAVDANVGRHLFQECICT--YLKDKARILVTHQLQFLKDADEIMVLQQGQCIDK-GTYQQLSRNDSGFLSLLA-----------EEVEEETGNESDGDDGSTRFGRPVSKQLSVEE---VVRKRAGNVVDSCMSIMSAATTLTLPPEETKQEGAVSRQTYAAYLRSFHDLGTGVFLIFLFAMCQVRPVMLMFGDVWLANWANREEVYSMTLASWNASSNTTSPSRP------DLH----YYLSVYAALVFGLFVLCLICTMSYYWFTIVASRNLHNGMFHSLIHTNMHFFDNNSIGRILNRFSKDIGVIDDFMPWMLCDVLQIGFSCLGIMCLVAASNPVSIAIVLPVICLFFYFRNYFMKSSREMKRIEGINRSPLFGHFSTTLLGIDTIRAYGVEATFTDQFNLFHDAHSRAWYAYLAG--QAWLTCRLQALGVVFLLFIVLGLPALKDGLSAGTVGLILSYSIMLAKLFEPFVEESAEVENIMTSVERVVEYTSLPPE-GEKVTDVIPPPDWPDKGKITFDNMSFSYHQSLPEVLHNVTCVIKPSEKVGVVGRTGAGKSSLLSTLFRLAEP-KGLIDIDGINIRKLGLKDLRSKLSIIPQDPVLFSGTMRKNLDPFSEHPDAGLWKVLDEVQLKQPVEDLPGKLDEELAEAGSNFSVGQRQLVCLARAILRHSRILVIDEATANVDPRTDALIQETIRDKFQDCTVLTIAHRLHTIMDSDRVMVLDAGRLVEFDAPYKLLKKRNTIFS 1262
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO38355 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SD35]) HSP 1 Score: 452.981 bits (1164), Expect = 7.337e-136 Identity = 360/1318 (27.31%), Postives = 644/1318 (48.86%), Query Frame = 2
Query: 623 LFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRP-FILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDT---DKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAV-LPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNG--------SFSWRSD---SEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLR--TNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGS--LQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIY-GLIGFGQI---IFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFL-GNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSK 4498
+F WL++ FQNG K + Y+ + + KL K + S+R + L+++ G+ ++ V ++P FI K + F+ T + A I + ++ + F T +R A ++ VY K++ +++ A ST T IINL+++D +++ + + WI +P +++ + E+G GV+V++ PL + + DKR + M EV++ M+VIK+Y+WE F +++ R EV++IR + V +I+ + M YV + ++ E F + L +R + + LP I VS KR+ FL E K+ S + +R++ E+K G +FS R + S P L+ IN + +L+ +VG + +GK+SLL ++GE+ + G +S+KG +SY Q WI S ++NI+ K+Y E Y VI+ C ++ D+R N + L G + SGGQ+ RINLARAVY ++I LLDDPLSA+D V +++F++ + G+L + + VT + +L II L ++G G + +S +D M + S S D ++I + + V ++ + + S + Y +I+ N + + + + +V+++ Y +YF A S ++ + FG ++ V +WL K + + + T T + Y+ IY G+I G + + A Y F AS+ +HD M ++VL++ + +F + +++N F+KDI+ +D ++P + + + + ++ + P L+ +P+ +L+ I +YL ++ + + L + SP++ + +L G IRA + ++ F + +T ++ + WL RLD + + + L+ ++VGL ++Y+ + + W I Q ++E N ++ER+ ++ ++ E + L PD +WP G I + Y + L N+ I + EK+GIVGRTG+GK+SL+ LF+L P G + ID + I D+ + D+R AI++ PQ+ +FSGT+R+N+DPF D L AL L ++ + + + + GS+ SVGQRQL+CLAR IL ++KI+V+DEATA+VD TD LI ETI+++F + T+L IAHR + + D D+++V+D G ++EF + ++ N G+FS+
Sbjct: 1 IFSWLNKL----FQNGNKHPLRNEDLYEAMEKDESKRLTDKLERLWKEEKEAAKSSKRKPS-------LSRSFVRFLGTHFMLIGLFAVAEEGMRITQPYFIGKLVSYFVPGSTTTKQEAYIYAAIMSIFSCVMAMVHHPLFFQTFRCGFHLRIACSTMVYRKAMCLSHSAYSTVTTGHIINLLTSDVQILERVAVFLHHLWI---APVLLLVTSVISWYELGPYCLPGVIVVVLIAPLQGWLGKKFAVIRNKTALQTDKRFRIMNEVISGMRVIKMYTWERPFANLVADVRRYEVSIIRKAAYLRSVNAVIYVMCIPVIGFAMFAPYV--LTGHALSPEKVFTVIALFYSIRVSLTIFLPECIRGLKESKVSAKRLQSFL-ERDEKH---SMKGVRTLTELKEGETASVKANNFSARWNDMISTPTLQGINFELKPSDLLMVVGPVGAGKSSLLMCLLGELPLTSGYISVKGRVSYASQQAWIFSGSVRENILFGKEYEEAKYWRVIKACAMERDMRLFPNGYETLVGEKGVALSGGQKARINLARAVYYDADIVLLDDPLSAVDTHVGRQLFDECVY--GLLKDRICVLVTHQLQYLKGATDIICL-QDGRCVGQGSYAELSEAGLDVMSLVSALSAGD-----HDNIISPDIINVPPSSAQFPVPLANGSTRPGYQKIS------------GNVDDAPEGEVLAREPSKEGQHTGTVTWQVYIEYFKAGASPCVRFLIVMLLFGSQAVVMV-GEWWLAKWADSEK---------EKSYLIESYRGTNSTPPPPADLTTHEYIYIYCGMICAGMVTSLVCAMMLYNFF----VTASQHLHDNMFSRVLRAPIYFFDTNPVGRVVNRFAKDINQMDDVLPAAFYDFLRVSLNLTS---LLGSSMPFLLVGAIPMTVLFGYIRNYYLRTSREVKRLEAINRSPVYSHLSTSLTGLITIRAFQAEQAFIRSYHAYTDFHTGSYFLFHTTQRWLGFRLDIICASFFTLATFTSLFIVEGGLS-NVVGLCLTYATQLTGMFQWCIRQSAEVENNMTSVERVIEYSQIDQEVEPSKPLTAPD-DWPHTGTITAESLYYSYHQSLPHVLKNVKFSIRNNEKVGIVGRTGAGKSSLLAVLFRLNNP-EGLVRIDGLPITDLKLQDLRSAISIIPQDPVLFSGTLRKNLDPFTQFSDDALWNALEEVQLKEAVDELPDGIETELAEGGSNFSVGQRQLVCLARAILSHNKILVIDEATANVDHSTDSLIQETIRNKFHDCTVLTIAHRLNTVMDSDRVMVLDAGRLVEFDEPYVLLLNSQGFFSQ 1258
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO37445 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFS6]) HSP 1 Score: 442.965 bits (1138), Expect = 1.065e-132 Identity = 348/1301 (26.75%), Postives = 622/1301 (47.81%), Query Frame = 2
Query: 620 ILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVF-HIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISL-CSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAV-LPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIE--IKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFN-DKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFS 4495
ILF W++ +Y F+ + +E +++ + D T N K ++ H P L K++ K+I F + + S +L + L+ + ++ L + + F + I +I++N ++++ A+ +Y K +N + + ST +INL+S D +I I + + P I++ L +G + G L L +A + + DKR+ AM+EV++ ++ +K+Y+WE + + R KE+ +IRL +L S V + + ++ L++++ IF + + F + LL L + V L + ++ +VS++R+ FL+ ++ S + +++ + W+ DS L+ ++ + G+LV I G + SGK++LL I GE+ + G++ G ++YV Q PW+ + ++NI K+Y + Y+ I++CDL D+ +L+ G + SGGQR R++LARAVY ++IYLLDDPLSA+DA V +F++ I G L N R+ VT + +L + + II L + KI + +F D H I S ++ +++ A ++ + N+ V+ ++ E+ D + SV Y+KYF A + IF F I+T +L+ W S+ + + A+ + + GL+G + L F + +S+ +H+ M +LKS + +F + S +I+N FSKDI +D IP S + +F M +L +P+ + + +I FYL S+ + Q L SP++ F +TL G VIR+S+ +K F +L + ++ + L + W++ LD + +F S + A + P+ G+ +S +I + ++ + + ++E ++ER+ ++ + SE ++ L P +WP G + F+ +L Y E L++I L I +K+GI GRTG+GK+SL+ +LF++ EP GG +LID ID+ IDI RRA+ + Q+ +F GT+R+N+DPF D + A+ L + ++ L + G++GS+ SVG+RQLLCLAR +L+ K++VLDEATA+VD TDR + + I+ RF T+L IAHR + + D DK+IV+D+G ++E+ + +G F+
Sbjct: 21 ILFSWMNGILYKGFKRNLTAEDLYELPQE---DQTTYNVKILEQEWIEEIRTAHRLGNYP--------RLYKSVLRALPGKVICKVLTFQFLRGLSTLSYTVLLWFFLRELGLGKSQLALSL-MVVGFTVVSISLAISRNQMELFGLYAGMRLKVALVGLIYKKILNSSRCSLSTVRTGHVINLISNDAKRIELFITNLCLAMLGPVSILVCIVMLCLFVGWQSLSGALFLFIIMLYGQLAAKRFAKLRGKAAAVTDKRLGAMSEVIHGIRAVKMYAWEWNYSDEVKGLRRKEMQIIRLKNLILSTFVALYSVSASIAALISII---TLIFSGIHLDSARIFTLINLLKTLEFAIVVHLGACLGTVLDAFVSIRRIEQFLLGTSSEINQISREGETTILSKTLTKRWIRWQDDS-CTLQGVSFAAGAGDLVIITGPVGSGKSTLLMTIQGELPLNAGSIRRHGHLAYVSQVPWVFSGTVRENITFGKEYDKAAYEKAIKVCDLAKDINRFPKGDLSCIGQRGVSLSGGQRARVSLARAVYADADIYLLDDPLSAVDAKVGSHLFKECIC--GALTNKVRILVTHQLQYLKHANSIIVLSDG--------------------KIAQKGTFQDIDVSHI-GIDVSKDSVIVS----------AAPVEGQQGNHNLIDGVPAVDMAD----------------EEEDQAVGSVKLSLYWKYFRAGLPAVVLFLIFIFCIITEASILAPMWWLSYLSE--------------------------MTPEKQASGSVLGVYAGLVGLSLLTATGMASLLF-IAALRSSENLHNAMTTTILKSPILFFDTNPSGRIMNRFSKDIGTMDDHIPLKFSWTVTLLFHFMGGLLFSAIVEYRLVLSAIPVFVAFLLICWFYLRSSRELQRLEAVRCSPVYSHFTDTLNGLEVIRSSRMEKGFWEQLIRHQDEQSMALSLVISARSWMNNNLDLVS--FLFVSAVAATAAITQQDPASTGMLLSLAIAMAQGTSYGVEKASEVENEMTSVERVISYTRLPSEPGYSRQTL--PCEDWPERGAVTFRDMSLVYREGTPSALDDITLEITAKQKVGIAGRTGAGKSSLLAALFRMPEP-GGEVLIDGIDLGTIDIQAARRAMAVITQDPVLFGGTLRRNLDPFGKFTDQEIWSAIESVQLLNTVRALPDQLMYQLGESGSTFSVGERQLLCLARALLQRCKVLVLDEATANVDYRTDRQVQQLIRSRFTGCTVLTIAHRLNTIMDYDKVIVLDKGHVVEYDTPEMLAGKQDGVFA 1224
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO37818 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEN5]) HSP 1 Score: 441.81 bits (1135), Expect = 6.487e-132 Identity = 354/1347 (26.28%), Postives = 654/1347 (48.55%), Query Frame = 2
Query: 590 PEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVF-HIIFSFSRPFILKYLLKFISA-PETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLI--RLISLCSGVVNI--IWDT-LPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAM----NGYVSLKRVSLFLI-----ENKTKNYFSSCQDIRSV-----------IEIKNGSFSWR-SDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRT-NQADE-LNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFL----MVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQ---VLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFH-QSSSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGS------VIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSK 4498
P+ ++I S+I F W++ Y + ++ + + A+ T ++ + L+ + P+ + W KAL V A+V + + P +L +L+ ++ + F + L +T + ++ Q+ + ++ ++ R+A +Y+K + ++ + ++ +INL+S D ++ A + + SPF+++++ L+ IG A G+ + P + W+ + + D+R++ M EV++ ++ +K+Y+WE + ++ + R LI ++ + S ++ +D+ + + +T+++T + P + T ++ +L L YG+T M + + SL R+ FL+ E + +SCQ+ R I + N + W +D P+L IN+ N+ +LV + G + SGK+SLL ++GE+ +G+V +G + YVPQ W+ + ++NI+ SK Y E Y+ + CDL D+ + Q D + G SGGQ+ R+NLARAVY +IYLLDDPLSA+DA V + +FE I+ G+L N R+ VT + L D I+ +D G+I + GD + + +D +S + F + E KYHQ++ ++Q L K++S+S + + + + ++S K Y++YF R L I + I Q + + WL HM+ ++IYG + G + A L + + S+ +HD M+ +LK+ + ++ S +ILN FSKDI +D +P + I Q +AS V T + +VP+ L + I ++YL ++ + + + S SP+ +TL+G +IR + F ++ + ++ ++ W+ +RLDF+ V + V+M +C+ L GL++ Y+I + L + + Q D+E ++ER+ ++ ++ E P+S WP G ++F+ +L+Y E L+N+N+ I+ GE++G+ GRTG+GK+SLV +LF++ +P G ++IDD +I ++I + RR I++ Q T+FSG++R N+DPF+ +D L L + ++ + G L+F+ ++G++ VG+RQLLCLAR +L +KIIV+DEATA+VD TDR I ETI+ +F T++ IAHR + + D DK++VM++G+ +EF E++ +G ++
Sbjct: 20 PKLRANILSKITFWWMNHIFYIGNKRPLEESDLYPLIEDDKAEYLTERLEKAWSKELE---------KIPMGKKPRFW---KALMRVCPVSEYFYIIALVLTDMANRMTLPVLLGFLISYLMGIRDLGASFRYVLPTGICLTSLGRNLAQHHYQNRSALLGMRFRAAATGILYNKVLRMSQSKLAKISSGHVINLVSNDIQRLDLATQNLFASLRSPFDLVVLGVLLWVLIGWQAVTGLAFALILIPYEAEMTGWVAKLRMQAARVTDRRLEVMNEVISGIRAVKMYAWEWPYRDVVRQIRRYGPVLIMRKIYGILSSFASLQHTYDSVICLIAFITLVFTGTRLTPYNIFT---------MVGLLSENRRSLVYGLTDGMQLIADCFASLDRIEHFLLIEELSETGGSSRKASCQEEREEENEEEKEGEPYIRVNNVACHWNGTDVSPVLSDINMDFNENKLVLVTGPVGSGKSSLLLTLLGELLPSEGSVKTRGEVVYVPQTAWVFSGTVRENILFSKPYDEERYQRTLEACDLAKDIVSLPQGDATILGERGASLSGGQKARVNLARAVYADGDIYLLDDPLSAVDAKVGKHIFENCIT--GVLENKIRILVTHQLQHLKNADYIMIMDR-GAISHEGDYQQVQDSGLDL------ESLEEEFRQGWE----------------------------KYHQLHDKEQPLSKEKQAVKKATKKDTSDSEPIQGMARKAEERHVGTISAKLYWRYF--RSGLHACLLILLVLLFLIAQASIISPNLWL----------------------------VHMSRMKWVEQKHKLNLIIYGCLVGGALFLAIIRGLLYYITTLRCSENLHDKMVVSILKTPVHFYDTNPSGRILNRFSKDIGIVDEFLPPTSLLALQYILQTLASVCVTCSTNYWAIFGVVPMLLGFIGINRYYLKTSREIKRMEAISQSPVLAHLADTLEGIVLIRTYHMENRFIQRFNEVQDHRSQIWFLVPHTARWMGIRLDFVCTAFVAIATFTGILVLMQMCFSGTL-----GLSLVYAISTVGQLQFAMRQTADVENMMTSVERVMSYTHLDEEPGYYIEKKAPES-WPAHGNVKFENVSLRYYEGGPQVLHNLNIDIKGGERVGVAGRTGAGKSSLVAALFRMPDP-EGKIIIDDQEIGQLNIQNTRRVISVITQNPTLFSGSLRINLDPFSRYDDAALWNVLEQVEMKDKVKELPGELYFELSESGNNFGVGERQLLCLARALLNKNKIIVMDEATANVDFNTDRSIQETIRSKFSGCTVITIAHRLNTILDYDKVLVMEKGQAMEFDSPDELLKRGDGMLTE 1271
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Match: EDO37461 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFS4]) HSP 1 Score: 439.499 bits (1129), Expect = 1.645e-131 Identity = 344/1317 (26.12%), Postives = 624/1317 (47.38%), Query Frame = 2
Query: 620 ILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSR-------PFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRL----ISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITI--------AMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIE--IKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN--GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSS-SQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFN-DKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFS 4495
ILF W++ +Y F+ + +E +++ + D T N + L+ + N ++ + + ++ K++ K+I C + + F F R +L + L+ + ++ L + + F + I +I++N ++++ A+ +Y K +N + + ST +INL+S D +I I+ + I PF+I++ L +G + G L L +A + + D+R+ A++EV++ ++ +K+Y+WE + I R E+ +IRL +S + ++ + ++T++++ +++ P + T ++N+L+S L + I + ++ +VS++R+ FL+ ++ SC+ +++ + W+ DS L+ ++ + G+LV I G + SGK++LL I GE+ + G++ G ++YV Q W+ + ++NI K+Y + Y+ I++CDL D+ +L+ G + SGGQR R++LARAVY ++IYLLDDPLSA+DA V +F++ I G L N R+ VT + +L + D II L + KI + +F D H I S ++ + + H I E+ D + SV Y+KYF A S + IF F + T +L+ W S+ + + A+ + + GL+G + L F + +S+ +H+ M +LKS + +F + +I+N FSKDI +D IP S + +F M +L +P+ + + +I FYL S+ + Q L SP++ F +TL G VIR+S+ +K F +L + ++ T L + W+ LD + +F S + A + P+ G+ +S +I + ++ + + ++E ++ER+ ++ + SE ++ L P +WP G + F+ +L Y E L++I L I +++GI GRTG+GK+ L+ +LF+L EP GG +LID +D+ IDI RRA+ + Q+ +F GT+R+N+DPF+ D + AL L + ++ L + G++GS+ SVG+RQLLCLAR +L+ K++VLDEATA+VD TDR + + I+ RF T+L IAHR + + D DK+IV+D+G ++E+ + +G F+
Sbjct: 21 ILFSWMNGILYKGFKRNLTAEDLYELPQE---DQTTYN-----VNILEQEWNEEIRTAHRLGNYPRLY---KSVLRALPGKVI---CKV---LTFQFLRGRSTLSYTVLLWFFLRELGLGKSQLALSL-MVVGFTVVSISRAISRNQMELFGLYAGMRLKVALIGLIYKKILNSSRCSLSTVRTGYVINLISNDAKRIELFISNFSMAILGPFKIVVCIVMLCLFVGWQSLSGALFLFIIMLYGQLAAKQFAKLRGKAAAVTDRRLGAVSEVIHGIRAMKMYAWEWNYSDEIKGLRRLEMQIIRLKNLILSTFVALYSVSASIAALISIITLIFSGIHLDPARIFT---------VINLLKS----LEFAIVVDLAECLREVLDAFVSIRRIEQFLLGASSEINRISCEGETTILSKTLTKRWIRWQDDS-CTLQGVSFAAGAGDLVIITGPVGSGKSTLLMTIQGELPLNAGSIRRHGHLAYVSQMSWVFSGTVRENITFGKEYGKAAYEKAIKVCDLAKDINRFPKGDLSCIGQRGVSLSGGQRTRVSLARAVYADADIYLLDDPLSAVDAKVGSHLFKECIC--GALTNKVRILVTHQLQYLKHADSIIVLSDG--------------------KIAQKGTFQDMDVSHI-GIDVSKDSVIDGAAPVEGQQGHHDLIDGA--------------------------PAVDMADEEEDQAVGSVRLSLYWKYFRAGLSAVVLLLIFIFCVFTEASILAPMWWLSYLSE--------------------------MTPEKQASGSVLGVYAGLVGLSLLTATGMASLLF-IAALRSSENLHNAMTTTILKSPILFFDTNPFGRIMNRFSKDIGTMDDHIPLKFSWTVTLLFHFMGVLLFSAIVEYRLVLSAIPVFVDFLLICWFYLRSSRELQRLEAVRCSPVYSHFTDTLTGLEVIRSSRMEKRFWEQLVRHQDEQTMALSLVISARRWMDNNLDLI--CFLFVSAVAATAAIIQQDPASTGMLLSLAIAMAQGTSYGVEKASEVENEMTSVERVISYTRLPSEPGYSRQTL--PCEDWPERGAVTFRDMSLVYREGTPSALDDITLEITAKQRVGIAGRTGAGKSFLLAALFRLPEP-GGEVLIDGVDLGTIDIQAARRAMAVITQDPVLFGGTLRRNLDPFDKFTDQEIWAALESVQLLNTVRALPDQLMYQLGESGSTFSVGERQLLCLARALLQRCKVLVLDEATANVDYRTDRQVQQLIRSRFTGCTVLTIAHRLNTIMDYDKVIVLDKGHVVEYDTPGMLAGKQDGVFA 1224
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789]) HSP 1 Score: 676.396 bits (1744), Expect = 0.000e+0 Identity = 451/1361 (33.14%), Postives = 727/1361 (53.42%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVAD-------VNTMNFKR---KLTSTLKSKNNYHTKSRRPINE-------------HSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFG-FTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQA-DELN-GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFL--DENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSK--YHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKS-VSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYML--IYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDS---EWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
+ +++ NPCPE +S SRI F W+ + S ++ ++ + + ++ + CV KR K+ + K + K R + E S+ W AL F ++S + I F P IL+ L+ F++ P+ P + G F A+ F+ T + S I Q FH+ + +++R+A+ A+Y K++ I++ A+ + T EI+NLMS D + + + Y ++ S+P +++L FL+ +G LA + V++LM P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + +S+ RE E+ +++ + V W P V L+ YV I V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + I I++G FSW P LKR+N+ I +G LV +VG + SGK+SLL+A++GEM ++G+VS+KGS++YVPQ WI + K+NI+ +K E Y V+ C L DL A DE G + SGGQ+QR++LARAVY +YLLDDPLSA+DA V + +F+ VI G+L + TR+ VT +++L ++ + E + Y + +F+++ + S E TE + S + N AS SK + N+ ++ NS++ K+ D D + V +F Y A G L S+ F +L + ++YWL T DP + N M +YG +G Q + C + L+ S+G AS+ +H ML VL+S + +F ++ S ++N F+K++D IDS+IP L + +F V+ S +IL P+ L+I +G+LYF + +FY+ S+ Q + L S SPI+ F+ETL G VIRA +++ F E + ++ N K Y V N WL++RL+F+GN +V + + A+ R L+P ++GL+ISY++ + L W++ D+ETN +A+ER+ ++ E E E+ + P + +WP G I F L+Y D + NIN+ I GEK+GIVGRTG+GK+SL LF+++EP G++ ID +DI + + ++R IT+ PQ+ +FSGT+R N+DPF+ D + +AL SHL ++ + L +C + G +LS+GQRQLLCLAR +LR +K++VLDEATA++D ETD LI TI+ +F T+L IAHR + + D +++V+D+G++ EF S +I ++ K
Sbjct: 199 SQAVKDPNPCPEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHCVVPQLLRRWTAECHKVKRTEEKMLYSPKQPPHGENKEVRAVEESEILIVKSPKKSREPSLLW---ALCLTFAPHFLVSCLYKLIQDILMFVGPEILRLLILFVNDPDAPSWQGYFYAALLFVCTCVQSLILQRY-FHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILM--VPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELKVLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELQEDSVERPAAGGSPYSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQLKEKEGAFAEFLRMYAANEQS----EETEPVPNSPTKPMENGVGPGFTGSQSASNVSKGSVSEQNVEQK--------------NSKNAEAGKTTDADKALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTDDPVV---------------------------NGTQPNRLMRLGVYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALIIPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKE---AEWRHEPPTVPPDWPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSLGQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLIAQKGAFYRMAK 1505 HSP 2 Score: 71.2478 bits (173), Expect = 8.402e-12 Identity = 52/222 (23.42%), Postives = 103/222 (46.40%), Query Frame = 2
Query: 3854 LNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI---KHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLY 4510
L +N+ I G + +VG GSGK+SL+ +L ++ + GS+ V+ ++ PQ++ I + T++ NI ++ + + L LE + + G+ G +LS GQ+Q + LAR + + + +LD+ ++VD + I + + + + T +++ H S L ++VM GEI E G ++ + ++Y
Sbjct: 658 LKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSV-------------SVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQLKEKEGAFAEFLRMY 866
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc6a (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101158001]) HSP 1 Score: 659.833 bits (1701), Expect = 0.000e+0 Identity = 418/1348 (31.01%), Postives = 712/1348 (52.82%), Query Frame = 2
Query: 575 NNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTF-----DVHYQCVADVNTMNFKRKLTSTLKSKNNYHTK----SRRPIN---------EHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTK----NYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDL--DFD-LRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSFSD---PFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQ--------INIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFN-DKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCK 4504
NPCP + +S S+ILF W + ++ +++ + D ++ ++D+ + + K + + + SR P E SS ++L + L FG + I+FH F F+ P +L LL FI PE P + G+ A + L S+ + + T ++V++A+ VY KS+ IN+ A+ T T EI+NL+S DT K++ + Y V +P EI L FL+ +G A G+ ++ FPLN Q +M++ D R++ M E+LN +K++K Y+WE F + + REKE+ ++ + + +++ + M YV + V+ A+ FVS+ L+N+L++P++ LP+ I+ M VSL+R+ +L + K + S D V+ I+NG+FSW + P LKRI++ + +G LV +VG + SGK+SLL+A++GE G V++KGS++YVPQ WI+ + +DNI+ ++ ++ Y+ V+ C L D D L A E+ G + SGGQ+QR++LARAVY+K+++YLLDDPLSA+DA V Q +F+KVI G+L + TR+ VT ++FL D I+ L +G I G + + +F+D FA TE ++ R++ R+ + Q N Q + + + +K YK YFK G + +F + + SYWL DP + + + ++G +GF Q I + S+ AS+ +H +L VL+S + +F + S +LN F K+ID ID ++P L +++ +F+++ ++L P+ ++I+P+ LY + FY+ ++CQ + L S SPI+ FNET+QG VIRA ++ F + + ++ N + + V WL++ L+F+GN +V + ++++ ++ ++P +VGL +S+S+ + +L+W++ + D+E N +++ER++ + E + + E P + WP+ G IEF+ + L+Y + + L I L I+ EKIGIVGRTG+GK+SL +F+++E G + ID ++I +I + D+R IT+ PQ+ +FSG++R N+DPF+ D + +L L+HL ++ ++ L+ +C + G +LS+GQRQL+CLAR +LR +KI+VLDEATA+VD ETD LI TI+ +F + T+L IAHR + + D ++IVMDRG I E + +I+ ++ C+
Sbjct: 201 EKNPCPVKDASFLSKILFWWFTGLVVKGYRTPLEATDLWTLREEDTSHKIISDLQ-QEWGAECAKLQKQEKSLESAPVLGSRLPDQAQLLRKLQKEQSSGFFLLRTLARKFGPYFLTGTLCIIFHDAFMFAIPQVLSLLLGFIRDPEAPQWKGYFYATLMFLLSCLQSLFNHQYMYTCFTVGMRVKTAVMGLVYRKSLVINSAARRTCTVGEIVNLVSADTQKLMDFVVYFNAVWLAPIEIGLCLFFLWQHLGPSALAGIATVILIFPLNGFIAKKRSKLQEIQMKFMDGRVRLMNEILNGIKILKFYAWEKAFLEQVLGYREKELKALKKSQVLYSISIASFNSSSFLIAFAMFGVYVMLDERNVLDAQKVFVSMALINILKTPLSQLPFAISTTMQALVSLRRLGKYLCSEELKVDGVSKALSSSDGEDVV-IENGTFSWSKEGPPCLKRISVRVPRGSLVAVVGHVGSGKSSLLSAMLGETEKRSGQVTVKGSVAYVPQQAWIQNATVQDNILFGREKLKTWYQRVLEACALLPDLDILPAGDATEI-GEKGLNLSGGQKQRVSLARAVYRKADLYLLDDPLSAVDAHVGQHIFDKVIGPKGVLKDRTRILVTHGMSFLPQADLILVLI-DGEITESGSYQEL---------LSHHGAFADFIHTFAS-TEKKESAIQRAGSRRSNARLSMVDFMPFSRDLSQEQLIGGDTTNTNLQNMEPVSENDQDQVPEDLGKLTEADKAHTGRVKLDMYKKYFKTI---GLAIIIPIVFLYAFQQGASLAYSYWLSMWADDPVV-------------------------NGTQTDRDLKLAVFGALGFVQGIAIFGTTVAISICGIIASRQLHMDLLVNVLRSPMAFFESTPSGNLLNRFVKEIDAIDCMVPEGLKMMLSYVFKLVEVCIIVLIATPIAAVIILPLAFLYAFVQSFYVATSCQLRRLEAVSRSPIYTHFNETVQGASVIRAFGEQSRFIMQANERVDFNQTSYFPRFVATRWLAVNLEFVGNGVVLAAAVLSVIGKSTVSPGIVGLAVSHSLQVTGILSWIVRSWTDVENNIVSVERVNEYADTPKEASWNTEGSALPLA-WPQSGTIEFQDYGLQYRKGLELALKGITLQIQKREKIGIVGRTGAGKSSLALGIFRILEAAKGRIFIDGVNIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDIYTDEEIWSSLELAHLKDFVSNLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKILVLDEATAAVDLETDTLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVMDRGYISEMDSPANLISQRGQFYRMCR 1505 HSP 2 Score: 64.3142 bits (155), Expect = 1.241e-9 Identity = 67/282 (23.76%), Postives = 125/282 (44.33%), Query Frame = 2
Query: 1712 NGYVSLKRVSLFLIENKTKNYFSSCQDI------RSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKG-------------SMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQADELN-----GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDAIDFMKIKSEKSF 2485
N VS++RV+ + K ++ + + IE ++ +R E LK I + I K E +GIVG+ +GK+SL I + G + I G ++ +PQ+P + S + N+ Y + + + + + L D +N D+LN G + + S GQRQ + LARA+ +K++I +LD+ +A+D + + + I + T L + +N + ++I +D G I +N+ + F ++ E
Sbjct: 1235 NNIVSVERVNEYADTPKEASWNTEGSALPLAWPQSGTIEFQDYGLQYRKGLELALKGITLQIQKREKIGIVGRTGAGKSSLALGIFRILEAAKGRIFIDGVNIAEIGLHDLRSRITIIPQDPVLFSGSLRMNLDPFDIYTDEEIWSSLELAHLK-DFVSNLPDKLNHECSEGGENL--SLGQRQLVCLARALLRKTKILVLDEATAAVD-LETDTLIQSTIRTQ--FEDCTVLTIAHRLNTIMDYTRVIVMD-RGYISEMDSPANLISQRGQFYRMCREAGL 1509
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789]) HSP 1 Score: 656.366 bits (1692), Expect = 0.000e+0 Identity = 442/1328 (33.28%), Postives = 708/1328 (53.31%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVAD-------VNTMNFKR---KLTSTLKSKNNYHTKSRRPINE-------------HSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFG-FTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQA-DELN-GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFL--DENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHAS--IKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKS-VSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYML--IYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDS---EWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLED 4405
+ +++ NPCPE +S SRI F W+ + S ++ ++ + + ++ + CV KR K+ + K + K R + E S+ W AL F ++S + I F P IL+ L+ F++ P+ P + G F A+ F+ T + S I Q FH+ + +++R+A+ A+Y K++ I++ A+ + T EI+NLMS D + + + Y ++ S+P +++L FL+ +G LA + V++LM P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + +S+ RE E+ +++ + V W P V L+ YV I V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + I I++G FSW P LKR+N+ I +G LV +VG + SGK+SLL+A++GEM ++G+VS+KGS++YVPQ WI + K+NI+ +K E Y V+ C L DL A DE G + SGGQ+QR++LARAVY +YLLDDPLSA+DA V + +F+ VI G+L + TR+ VT +++L ++ + E + Y + +F+++ + S E TE + S + N AS K + N+ ++ NS++ K+ D D + V +F Y A G L S+ F +L + ++YWL T DP + N M +YG +G Q + C + L+ S+G AS+ +H ML VL+S + +F ++ S ++N F+K++D IDS+IP L + +F V+ S +IL P+ L+I +G+LYF + +FY+ S+ Q + L S SPI+ F+ETL G VIRA +++ F E + ++ N K Y V N WL++RL+F+GN +V + + A+ R L+P ++GL+ISY++ + L W++ D+ETN +A+ER+ ++ E E E+ + P + +WP G I F L+Y D + NIN+ I GEK+GIVGRTG+GK+SL LF+++EP G++ ID +DI + + ++R IT+ PQ+ +FSGT+R N+DPF+ D + +AL SHL ++ + L +C + G +LS+GQRQLLCLAR +LR +K++VLDEATA++D ETD LI TI+ +F T+L IAHR + + D
Sbjct: 199 SQAVKDPNPCPEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHCVVPQLLRRWTAECHKVKRTEEKMLYSPKQPPHGENKEVRAVEESEILIVKSPKKSREPSLLW---ALCLTFAPHFLVSCLYKLIQDILMFVGPEILRLLILFVNDPDAPSWQGYFYAALLFVCTCVQSLILQR-YFHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILM--VPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELKVLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELQEDSVERPAAGGSPYSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQLKEKEGAFAEFLRMYAANEQS----EETEPVPNSPTKPMENGVGPGFTGSQSASNVSKGSVSEQNVEQK--------------NSKNAEAGKTTDADKALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTDDPVV---------------------------NGTQPNRLMRLGVYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALIIPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKE---AEWRHEPPTVPPDWPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSLGQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMD 1472 HSP 2 Score: 71.633 bits (174), Expect = 6.985e-12 Identity = 52/222 (23.42%), Postives = 103/222 (46.40%), Query Frame = 2
Query: 3854 LNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI---KHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLY 4510
L +N+ I G + +VG GSGK+SL+ +L ++ + GS+ V+ ++ PQ++ I + T++ NI ++ + + L LE + + G+ G +LS GQ+Q + LAR + + + +LD+ ++VD + I + + + + T +++ H S L ++VM GEI E G ++ + ++Y
Sbjct: 658 LKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSV-------------SVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQLKEKEGAFAEFLRMY 866
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789]) HSP 1 Score: 656.366 bits (1692), Expect = 0.000e+0 Identity = 442/1328 (33.28%), Postives = 708/1328 (53.31%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVAD-------VNTMNFKR---KLTSTLKSKNNYHTKSRRPINE-------------HSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFG-FTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQA-DELN-GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFL--DENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHAS--IKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKS-VSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYML--IYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDS---EWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLED 4405
+ +++ NPCPE +S SRI F W+ + S ++ ++ + + ++ + CV KR K+ + K + K R + E S+ W AL F ++S + I F P IL+ L+ F++ P+ P + G F A+ F+ T + S I Q FH+ + +++R+A+ A+Y K++ I++ A+ + T EI+NLMS D + + + Y ++ S+P +++L FL+ +G LA + V++LM P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + +S+ RE E+ +++ + V W P V L+ YV I V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + I I++G FSW P LKR+N+ I +G LV +VG + SGK+SLL+A++GEM ++G+VS+KGS++YVPQ WI + K+NI+ +K E Y V+ C L DL A DE G + SGGQ+QR++LARAVY +YLLDDPLSA+DA V + +F+ VI G+L + TR+ VT +++L ++ + E + Y + +F+++ + S E TE + S + N AS K + N+ ++ NS++ K+ D D + V +F Y A G L S+ F +L + ++YWL T DP + N M +YG +G Q + C + L+ S+G AS+ +H ML VL+S + +F ++ S ++N F+K++D IDS+IP L + +F V+ S +IL P+ L+I +G+LYF + +FY+ S+ Q + L S SPI+ F+ETL G VIRA +++ F E + ++ N K Y V N WL++RL+F+GN +V + + A+ R L+P ++GL+ISY++ + L W++ D+ETN +A+ER+ ++ E E E+ + P + +WP G I F L+Y D + NIN+ I GEK+GIVGRTG+GK+SL LF+++EP G++ ID +DI + + ++R IT+ PQ+ +FSGT+R N+DPF+ D + +AL SHL ++ + L +C + G +LS+GQRQLLCLAR +LR +K++VLDEATA++D ETD LI TI+ +F T+L IAHR + + D
Sbjct: 199 SQAVKDPNPCPEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHCVVPQLLRRWTAECHKVKRTEEKMLYSPKQPPHGENKEVRAVEESEILIVKSPKKSREPSLLW---ALCLTFAPHFLVSCLYKLIQDILMFVGPEILRLLILFVNDPDAPSWQGYFYAALLFVCTCVQSLILQR-YFHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILM--VPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELKVLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELQEDSVERPAAGGSPYSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQLKEKEGAFAEFLRMYAANEQS----EETEPVPNSPTKPMENGVGPGFTGSQSASNVSKGSVSEQNVEQK--------------NSKNAEAGKTTDADKALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTDDPVV---------------------------NGTQPNRLMRLGVYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALIIPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKE---AEWRHEPPTVPPDWPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSLGQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMD 1472 HSP 2 Score: 71.633 bits (174), Expect = 7.795e-12 Identity = 52/222 (23.42%), Postives = 103/222 (46.40%), Query Frame = 2
Query: 3854 LNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI---KHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLY 4510
L +N+ I G + +VG GSGK+SL+ +L ++ + GS+ V+ ++ PQ++ I + T++ NI ++ + + L LE + + G+ G +LS GQ+Q + LAR + + + +LD+ ++VD + I + + + + T +++ H S L ++VM GEI E G ++ + ++Y
Sbjct: 658 LKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSV-------------SVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQLKEKEGAFAEFLRMY 866
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Match: abcc1 (multidrug resistance-associated protein 1 [Source:NCBI gene;Acc:101173789]) HSP 1 Score: 655.981 bits (1691), Expect = 0.000e+0 Identity = 442/1328 (33.28%), Postives = 708/1328 (53.31%), Query Frame = 2
Query: 560 NSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQ----CVAD-------VNTMNFKR---KLTSTLKSKNNYHTKSRRPINE-------------HSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFG-FTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGS--LASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKN---YFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRICDLDFDLRTNQA-DELN-GVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFL--DENGSIKYYGDVSNISNDAIDFMKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHAS--IKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKS-VSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYML--IYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQS-SSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDS---EWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLED 4405
+ +++ NPCPE +S SRI F W+ + S ++ ++ + + ++ + CV KR K+ + K + K R + E S+ W AL F ++S + I F P IL+ L+ F++ P+ P + G F A+ F+ T + S I Q FH+ + +++R+A+ A+Y K++ I++ A+ + T EI+NLMS D + + + Y ++ S+P +++L FL+ +G LA + V++LM P+N++ + YQ +M+ KD RIK M E+LN +KV+KLY+WE F + +S+ RE E+ +++ + V W P V L+ YV I V+ AE FVS+ L N+LR P+ +LP I+ + VSLKR+ +FL + + + I I++G FSW P LKR+N+ I +G LV +VG + SGK+SLL+A++GEM ++G+VS+KGS++YVPQ WI + K+NI+ +K E Y V+ C L DL A DE G + SGGQ+QR++LARAVY +YLLDDPLSA+DA V + +F+ VI G+L + TR+ VT +++L ++ + E + Y + +F+++ + S E TE + S + N AS K + N+ ++ NS++ K+ D D + V +F Y A G L S+ F +L + ++YWL T DP + N M +YG +G Q + C + L+ S+G AS+ +H ML VL+S + +F ++ S ++N F+K++D IDS+IP L + +F V+ S +IL P+ L+I +G+LYF + +FY+ S+ Q + L S SPI+ F+ETL G VIRA +++ F E + ++ N K Y V N WL++RL+F+GN +V + + A+ R L+P ++GL+ISY++ + L W++ D+ETN +A+ER+ ++ E E E+ + P + +WP G I F L+Y D + NIN+ I GEK+GIVGRTG+GK+SL LF+++EP G++ ID +DI + + ++R IT+ PQ+ +FSGT+R N+DPF+ D + +AL SHL ++ + L +C + G +LS+GQRQLLCLAR +LR +K++VLDEATA++D ETD LI TI+ +F T+L IAHR + + D
Sbjct: 237 SQAVKDPNPCPEPGASFLSRITFWWISGMMLSGYKRPLEEKDLWSLNPEDRSHCVVPQLLRRWTAECHKVKRTEEKMLYSPKQPPHGENKEVRAVEESEILIVKSPKKSREPSLLW---ALCLTFAPHFLVSCLYKLIQDILMFVGPEILRLLILFVNDPDAPSWQGYFYAALLFVCTCVQSLILQR-YFHVCFVSGMRLRTAVIGAIYRKALVISSAARRSSTVGEIVNLMSVDAQRFMDLVTYINMIWSAPLQVVLALYFLWENLGPSVLAGVAVMILM--VPINAVIAMKTKTYQVAQMKNKDSRIKLMNEMLNGIKVLKLYAWEMAFKEKVSQIRENELKVLKKAAYLGAVSTFTWVCAPFLVALSTFSVYVLIDDQNVLDAEKAFVSLALFNILRFPLNMLPMVISSMVQASVSLKRLRVFLSHEELQEDSVERPAAGGSPYSISIEDGVFSWSRSESPTLKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSVSVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQLKEKEGAFAEFLRMYAANEQS----EETEPVPNSPTKPMENGVGPGFTGSQSASNVSKGSVSEQNVEQK--------------NSKNAEAGKTTDADKALTGRVKLSVFFSYLKAIGVLLSIISLLFFLSHNLLSLFANYWLSLWTDDPVV---------------------------NGTQPNRLMRLGVYGALGVSQGVAVCGYSLSVSIGGILASRFLHQSMLFDVLRSPMSFFERTPSGNLVNRFAKEMDTIDSVIPMILKMFMGSLFNVVGSCIIILVATPMVALIIPFLGVLYFFVQRFYVASSRQLKRLESVSRSPIYTHFSETLLGTSVIRAFGEQERFIHESDQRVDHNQKAYYPGIVANRWLAVRLEFVGNCIVSFAALFAVLARESLSPGIMGLSISYALQLTASLTWLVRMSSDVETNIVAVERVKEYSDTEKE---AEWRHEPPTVPPDWPTEGCIRITNFGLRYRSDLDLAIRNINVDISGGEKVGIVGRTGAGKSSLTLGLFRIIEPAEGNIFIDGVDIAKLGLHELRSRITIIPQDPVLFSGTLRMNLDPFDSYSDEDIWKALEFSHLKSFVSGLPDKLGHECSEGGENLSLGQRQLLCLARALLRKTKVLVLDEATAAIDMETDDLIQTTIRSQFEGCTVLTIAHRLNTIMD 1510 HSP 2 Score: 71.2478 bits (173), Expect = 8.319e-12 Identity = 52/222 (23.42%), Postives = 103/222 (46.40%), Query Frame = 2
Query: 3854 LNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETI---KHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLY 4510
L +N+ I G + +VG GSGK+SL+ +L ++ + GS+ V+ ++ PQ++ I + T++ NI ++ + + L LE + + G+ G +LS GQ+Q + LAR + + + +LD+ ++VD + I + + + + T +++ H S L ++VM GEI E G ++ + ++Y
Sbjct: 696 LKRLNVRIPEGSLVAVVGHVGSGKSSLLSALLGEMDKMEGSV-------------SVKGSVAYVPQQAWILNATLKNNIVFGQKRKEAWYHRVVEACALHQDLEILPAGDETEIGEKGVNLSGGQKQRVSLARAVYCDRSVYLLDDPLSAVDAHVGKHIFDHVIGPQGLLKDKTRILVTHGLSYLPQAHLVLVMVDGEITEVGSYQQLKEKEGAFAEFLRMY 904
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000018910.1 (SMESG000018910.1) HSP 1 Score: 1284.63 bits (3323), Expect = 0.000e+0 Identity = 672/673 (99.85%), Postives = 673/673 (100.00%), Query Frame = 2
Query: 77 MTINVLHVLQLTSCSYFLIQFLLYLHKRHYETSRPIVRINFNKGYILCYSLNFLMVILLSFETIKNYSRNELFSSFIYYMWSVTTILVVVLFEIRRRTMHPMCYILFSYLTFTTSLCIIRYCQEFYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNV 2095
MTINVLHVLQLTSCSYFLIQFLLYLHKRHYETSRPIVRINFNKGYILCYSLNFLMVILLSFETIKNYSRNELFSSFIYYMWSVTTILVVVLFEIRRRTMHPMCYILFSYLTFTTSLCIIRYCQEFYELSDEIHSESSSIGILLILNLMSLIFSSISSYSPENSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKN+
Sbjct: 1 MTINVLHVLQLTSCSYFLIQFLLYLHKRHYETSRPIVRINFNKGYILCYSLNFLMVILLSFETIKNYSRNELFSSFIYYMWSVTTILVVVLFEIRRRTMHPMCYILFSYLTFTTSLCIIRYCQEFYELSDEIHSESSSIGILLILNLMSLIFSSISSYSPENSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNM 673
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000018912.1 (SMESG000018912.1) HSP 1 Score: 1235.32 bits (3195), Expect = 0.000e+0 Identity = 685/686 (99.85%), Postives = 685/686 (99.85%), Query Frame = 2
Query: 2459 MKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVXXXXXXXXXXXXXXXXXXXXEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILXXXXXXXXXXXXXXXXXXXHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSSSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTXXXXXXXXXXXXXXYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLXXXXXXXXXXXXXXXXXXTMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLHFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLYEC 4516
MKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVNNSEINKNSSNSRSLSQSKSEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILNNTIIGNFDNKNNNNQNHNHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSSSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTFPLFLLLIVPIGLLYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLIDDIDIRDIDITDVRRAITMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNL FDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLYEC
Sbjct: 1 MKIKSEKSFSDPFAEHTESIFTSNNNCVMNRNSCRIHKILHASIKSKYHQINIRKQFLMVNNSEINKNSSNSRSLSQSKSEDFDTEIKSVSYKAYFKYFLARGSLQLFCSIFAFGILTILQVLSSYWLEKLTSDPNILNNTIIGNFDNKNNNNQNHNHMTYSYDYHATANYYMLIYGLIGFGQIIFACFFYLTFSLGNANASKAIHDCMLNKVLKSKLQYFHQSSSQILNFFSKDIDNIDSLIPNNLSEVINCIFQVMASFFVILHTFPLFLLLIVPIGLLYFIILKFYLPSACQTQMLCVKSSSPIFRFFNETLQGRPVIRASKQKKHFQFELFKLLNDNTKFLYIQNVLNLWLSLRLDFLGNILVFGSVIMAICYRNKLTPSLVGLTISYSIDIIDLLNWMIIQYVDLETNSMALERLSNFNAMESEFNDKEYLYHPDSEWPRFGKIEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLIDDIDIRDIDITDVRRAITMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLDFDCGDNGSSLSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHRFINSTILIIAHRTSGLEDLDKIIVMDRGEIIEFGKTSEIINNPNGYFSKCKLYEC 686 HSP 2 Score: 68.5514 bits (166), Expect = 2.941e-11 Identity = 62/239 (25.94%), Postives = 106/239 (44.35%), Query Frame = 2
Query: 1805 IEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAV-------------SIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNVIRIC-----------DLDFDLRTNQADELNGVDRMLCSGGQRQRINLARAVYQKSEIYLLDDPLSALDAVVAQKVFEKVISNNGILANTTRLFVTQNINFLNYLDKIIFLDENGSIKYYGDVSNISNDA 2449
IE K + + D + L IN+ I GE +GIVG+ SGKTSL+ ++ + + G++ ++ +++ PQ I + + NI ++ K + + +LDFD N + S GQRQ + LAR + + S+I +LD+ +++D + + E + N+T L + + L LDKII +D G I +G S I N+
Sbjct: 449 IEFKKFNLKYVEDCKFCLNNINLVIEHGEKIGIVGRTGSGKTSLVQSLFKLVEPIGGSLLIDDIDIRDIDITDVRRAITMFPQESTIFSGTIRQNIDPFNFLEDHVLKQALNLSHLGPWLESINGNLDFDCGDNGSS---------LSVGQRQLLCLARVILRNSKIIVLDEATASVDQETDRLIMETIKHR---FINSTILIIAHRTSGLEDLDKIIVMDR-GEIIEFGKTSEIINNP 674
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000018910.1 (SMESG000018910.1) HSP 1 Score: 1088.56 bits (2814), Expect = 0.000e+0 Identity = 574/575 (99.83%), Postives = 575/575 (100.00%), Query Frame = 2
Query: 371 MHPMCYILFSYLTFTTSLCIIRYCQEFYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNV 2095
MHPMCYILFSYLTFTTSLCIIRYCQEFYELSDEIHSESSSIGILLILNLMSLIFSSISSYSPENSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKN+
Sbjct: 1 MHPMCYILFSYLTFTTSLCIIRYCQEFYELSDEIHSESSSIGILLILNLMSLIFSSISSYSPENSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNM 575
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000018910.1 (SMESG000018910.1) HSP 1 Score: 1079.7 bits (2791), Expect = 0.000e+0 Identity = 571/572 (99.83%), Postives = 572/572 (100.00%), Query Frame = 2
Query: 380 MCYILFSYLTFTTSLCIIRYCQEFYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNV 2095
MCYILFSYLTFTTSLCIIRYCQEFYELSDEIHSESSSIGILLILNLMSLIFSSISSYSPENSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKN+
Sbjct: 1 MCYILFSYLTFTTSLCIIRYCQEFYELSDEIHSESSSIGILLILNLMSLIFSSISSYSPENSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNM 572
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Match: SMESG000018910.1 (SMESG000018910.1) HSP 1 Score: 991.875 bits (2563), Expect = 0.000e+0 Identity = 557/673 (82.76%), Postives = 575/673 (85.44%), Query Frame = 2
Query: 77 MTINVLHVLQLTSCSYFLIQFLLYLHKRHYETSRPIVRINFNKGYILCYSLNFLMVILLSFETIKNYSRNELFSSFIYYMWSVTTILVVVLFEIRRRTMHPMCYILFSYLTFTTSLCIIRYCQEFYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXNSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLFFKIISRNREKEVNLIRLISLCSGVVNIIWDTLPMSVLLTMLWTYVNIFPNYVITAEATFVSVVLLNMLRSPMAVLPYGITIAMNGYVSLKRVSLFLIENKTKNYFSSCQDIRSVIEIKNGSFSWRSDSEPILKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNV 2095
MTINVLHVLQLTSCSYFLIQFLLYLHKRHYETSRPIVRINFNKGYILCYSLNFLMVILLSFETIKNYSRNELFSSFIYYMWSVTTILVVVLFEIRRRTMHPMCYILFSYLTFTTSLCIIRYCQEFYELSDEIHSESSSIGILLILNLMSLIFSSISSYSPENSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESL + E ++ +C + + D V + +V + T+ S L N R N Y+ S+ I+N + ++ S + I LKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKN+
Sbjct: 1 MTINVLHVLQLTSCSYFLIQFLLYLHKRHYETSRPIVRINFNKGYILCYSLNFLMVILLSFETIKNYSRNELFSSFIYYMWSVTTILVVVLFEIRRRTMHPMCYILFSYLTFTTSLCIIRYCQEFYELSDEIHSESSSIGILLILNLMSLIFSSISSYSPENSVIENNNPCPEEYSSIPSRILFMWLDRYIYSWFQNGIKSESTFDVHYQCVADVNTMNFKRKLTSTLKSKNNYHTKSRRPINEHSSVWWLTKALFHVFGSKLIISWCAIVFHIIFSFSRPFILKYLLKFISAPETPLFFGFTLAISFLITGILSSITQNCCFHLTSTTSLQVRSAIASAVYSKSININNEAKSTFTNAEIINLMSTDTDKIVTAIAYSWIVISSPFEIILIFAFLFNEIGSLASIGVLVLMGTFPLNSIAMSWLQHYQTEEMEWKDKRIKAMTEVLNNMKVIKLYSWESLSSQYNLGYTSNERAFDNVVDICQYIPKLC-DNCRSDVCICCFVEHVKV----------TYGSFALRNNYR--------------NEYIR----SVIEIKNGSFSWRSDSEPI--------------------LKRINISINKGELVGIVGKIASGKTSLLNAIIGEMCILDGAVSIKGSMSYVPQNPWIRKISTKDNIILSKKYIENDYKNM 624 HSP 2 Score: 135.191 bits (339), Expect = 3.444e-32 Identity = 61/63 (96.83%), Postives = 63/63 (100.00%), Query Frame = 1
Query: 1531 SSQYNLGYTSNERAFDNVVDICQYIPKLCDNCRSDVCICCFVEHVKVTYGSFALRNNYRNEWL 1719
SSQYNLGYTSNERAFDNVVDICQYIPKLCDNCRSDVCICCFVEHVKVTYGSFALRNNYRNE++
Sbjct: 462 SSQYNLGYTSNERAFDNVVDICQYIPKLCDNCRSDVCICCFVEHVKVTYGSFALRNNYRNEYI 524 The following BLAST results are available for this feature:
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Multidrug resistance-associated protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029981 ID=SMED30029981|Name=Multidrug resistance-associated protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=4628bpback to top protein sequence of SMED30029981-orf-1 >SMED30029981-orf-1 ID=SMED30029981-orf-1|Name=SMED30029981-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1481bp MTINVLHVLQLTSCSYFLIQFLLYLHKRHYETSRPIVRINFNKGYILCYSback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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