Aristaless related homeobox

Overview


Name	Aristaless related homeobox
Smed ID	SMED30029943
Length (bp)	1189

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Aristaless related homeobox (SMED30029943) t-SNE clustered cells

Violin plots show distribution of expression levels for Aristaless related homeobox (SMED30029943) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Aristaless related homeobox (SMED30029943) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Aristaless related homeobox (SMED30029943) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30029943

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
nervous system	SMED30029943	SMESG000017304.1	dd_Smed_v4_36829_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Aristaless related homeobox vs. Ensembl Human
Match: ARX (aristaless related homeobox [Source:HGNC Symbol;Acc:HGNC:18060])

HSP 1 Score: 106.301 bits (264), Expect = 2.451e-24
Identity = 53/98 (54.08%), Postives = 67/98 (68.37%), Query Frame = 1

Query:  340 ENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            + ++L H  +++     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  292 KEELLLHPEDAEGKDGEDSVCL-SAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 388

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BLAST of Aristaless related homeobox vs. Ensembl Human
Match: PAX3 (paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617])

HSP 1 Score: 100.138 bits (248), Expect = 1.218e-22
Identity = 54/120 (45.00%), Postives = 73/120 (60.83%), Query Frame = 1

Query:  361 THNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIP 720
            +  + + Q  + +D++S   D   + K RRSRTTFT  Q+++LERAF +  YPD+ TREELA    L+EARVQVWF NRRA+WRK         Q  A +L+ FN+ I  P   PP  +P
Sbjct:  193 SERASAPQSDEGSDIDS-EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRK---------QAGANQLMAFNHLI--PGGFPPTAMP 300

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Human
Match: PAX3 (paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617])

HSP 1 Score: 100.138 bits (248), Expect = 1.353e-22
Identity = 54/120 (45.00%), Postives = 73/120 (60.83%), Query Frame = 1

Query:  361 THNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIP 720
            +  + + Q  + +D++S   D   + K RRSRTTFT  Q+++LERAF +  YPD+ TREELA    L+EARVQVWF NRRA+WRK         Q  A +L+ FN+ I  P   PP  +P
Sbjct:  193 SERASAPQSDEGSDIDS-EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRK---------QAGANQLMAFNHLI--PGGFPPTAMP 300

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Human
Match: PAX3 (paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617])

HSP 1 Score: 100.523 bits (249), Expect = 1.500e-22
Identity = 54/120 (45.00%), Postives = 73/120 (60.83%), Query Frame = 1

Query:  361 THNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIP 720
            +  + + Q  + +D++S   D   + K RRSRTTFT  Q+++LERAF +  YPD+ TREELA    L+EARVQVWF NRRA+WRK         Q  A +L+ FN+ I  P   PP  +P
Sbjct:  192 SERASAPQSDEGSDIDS-EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRK---------QAGANQLMAFNHLI--PGGFPPTAMP 299

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Human
Match: PAX3 (paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617])

HSP 1 Score: 100.523 bits (249), Expect = 1.567e-22
Identity = 54/120 (45.00%), Postives = 73/120 (60.83%), Query Frame = 1

Query:  361 THNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIP 720
            +  + + Q  + +D++S   D   + K RRSRTTFT  Q+++LERAF +  YPD+ TREELA    L+EARVQVWF NRRA+WRK         Q  A +L+ FN+ I  P   PP  +P
Sbjct:  193 SERASAPQSDEGSDIDS-EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRK---------QAGANQLMAFNHLI--PGGFPPTAMP 300

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Celegans
Match: ceh-17 (C. Elegans Homeobox; CEH-17 [Source:UniProtKB/TrEMBL;Acc:G5EC89])

HSP 1 Score: 92.0485 bits (227), Expect = 2.966e-21
Identity = 40/61 (65.57%), Postives = 50/61 (81.97%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            K RR RTTFT  Q+++LER+F +  YPD+ TREE+A  +DL+EARVQVWFQNRRAK+RK E
Sbjct:  148 KQRRIRTTFTSGQLKELERSFCETHYPDIYTREEIAMRIDLTEARVQVWFQNRRAKYRKQE 208

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BLAST of Aristaless related homeobox vs. Ensembl Celegans
Match: unc-4 (Homeobox protein unc-4 [Source:UniProtKB/Swiss-Prot;Acc:P29506])

HSP 1 Score: 91.2781 bits (225), Expect = 8.233e-21
Identity = 46/87 (52.87%), Postives = 54/87 (62.07%), Query Frame = 1

Query:  385 EYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQ 645
            E D   L   N       K RR+RT F+G Q+++LE AF    YPDV  RE LA  LDL E+RVQVWFQNRRAKWRK E   + SS+
Sbjct:   69 EDDGIALEDDNDTGESAAKRRRTRTNFSGWQLEELESAFEASHYPDVFMREALAMRLDLLESRVQVWFQNRRAKWRKREQNRNGSSE 155

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BLAST of Aristaless related homeobox vs. Ensembl Celegans
Match: alr-1 (AristaLess (Drosophila homeodomain) Related [Source:UniProtKB/TrEMBL;Acc:Q21836])

HSP 1 Score: 92.4337 bits (228), Expect = 1.421e-20
Identity = 41/67 (61.19%), Postives = 52/67 (77.61%), Query Frame = 1

Query:  421 DTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            D N + K RR RTTF+  Q+ +LE+ F++  YPDV TREELA+ + L+EARVQVWFQNRRAK+RK E
Sbjct:  110 DDNGKRKQRRYRTTFSAFQLDELEKVFARTHYPDVFTREELATRVQLTEARVQVWFQNRRAKYRKQE 176

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BLAST of Aristaless related homeobox vs. Ensembl Celegans
Match: unc-42 (pep chromosome:WBcel235:V:9764645:9767679:-1 gene:WBGene00006778.1 transcript:F58E6.10d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-42)

HSP 1 Score: 89.3521 bits (220), Expect = 1.622e-20
Identity = 44/75 (58.67%), Postives = 53/75 (70.67%), Query Frame = 1

Query:  406 NSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKF 630
            +SI   TN   + RR RTTFT  Q+Q+L+ AF K  YPD+  REELA I  L+EAR+QVWFQNRRAK RKHE + 
Sbjct:   23 SSIAGVTNTPAR-RRHRTTFTQEQLQELDAAFQKSHYPDIYVREELARITKLNEARIQVWFQNRRAKHRKHEKQL 96

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Celegans
Match: unc-42 (pep chromosome:WBcel235:V:9764645:9769361:-1 gene:WBGene00006778.1 transcript:F58E6.10a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:unc-42)

HSP 1 Score: 90.1225 bits (222), Expect = 2.429e-20
Identity = 44/75 (58.67%), Postives = 53/75 (70.67%), Query Frame = 1

Query:  406 NSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKF 630
            +SI   TN   + RR RTTFT  Q+Q+L+ AF K  YPD+  REELA I  L+EAR+QVWFQNRRAK RKHE + 
Sbjct:   74 SSIAGVTNTPAR-RRHRTTFTQEQLQELDAAFQKSHYPDIYVREELARITKLNEARIQVWFQNRRAKHRKHEKQL 147

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BLAST of Aristaless related homeobox vs. Ensembl Fly
Match: hbn (gene:FBgn0008636 transcript:FBtr0071556)

HSP 1 Score: 105.531 bits (262), Expect = 9.269e-25
Identity = 50/68 (73.53%), Postives = 54/68 (79.41%), Query Frame = 1

Query:  418 SDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            SD  +  K RRSRTTFT  Q+ +LERAF K QYPDV TRE+LA  LDLSEARVQVWFQNRRAKWRK E
Sbjct:  145 SDMERPRKVRRSRTTFTTFQLHQLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAKWRKRE 212

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Fly
Match: Rx (gene:FBgn0020617 transcript:FBtr0342783)

HSP 1 Score: 99.3673 bits (246), Expect = 3.401e-22
Identity = 56/134 (41.79%), Postives = 75/134 (55.97%), Query Frame = 1

Query:  352 LNHTHNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFS-----TSSQNIAERL-LGFNNQIFYPNLQPPFMIPQQNFI 735
            LN T++S+  ++  +   +    D   + K RR+RTTFT  Q+ +LERAF K  YPDV +REELA  ++L E RVQVWFQNRRAKWR+ E   S     T    +  RL  G +     P L PP +     F+
Sbjct:  529 LNQTNSSEQGEKITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLSALPGFL 662

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Fly
Match: gsb-n (gene:FBgn0001147 transcript:FBtr0072461)

HSP 1 Score: 97.0561 bits (240), Expect = 8.513e-22
Identity = 55/119 (46.22%), Postives = 70/119 (58.82%), Query Frame = 1

Query:  271 EKLTDLKKESYLDRYGMKSDKIDENQMLNHTHNSD-SSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            E   D    S + R    SD+  E+   ++T N     ++ D +D  S      K+ K RRSRTTFT  Q++ LERAFS+ QYPDV TREELA    L+EAR+QVWF NRRA+ RKH  
Sbjct:  125 EGFADPPSTSSISRLLRGSDRGSEDGRKDYTINGILGGRDSDISDTESEPGIPLKR-KQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKHSG 242

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Fly
Match: al (gene:FBgn0000061 transcript:FBtr0078053)

HSP 1 Score: 96.6709 bits (239), Expect = 1.020e-21
Identity = 42/61 (68.85%), Postives = 50/61 (81.97%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            K RR RTTFT  Q+++LE+AFS+  YPDV TREELA  + L+EAR+QVWFQNRRAKWRK E
Sbjct:   84 KQRRYRTTFTSFQLEELEKAFSRTHYPDVFTREELAMKIGLTEARIQVWFQNRRAKWRKQE 144

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Fly
Match: Pph13 (gene:FBgn0023489 transcript:FBtr0078070)

HSP 1 Score: 95.5153 bits (236), Expect = 1.371e-21
Identity = 43/61 (70.49%), Postives = 48/61 (78.69%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            K RR RTTF   Q+Q+LERAF +  YPDV  REELA  +DL+EARVQVWFQNRRAKWRK E
Sbjct:    9 KQRRYRTTFNTLQLQELERAFQRTHYPDVFFREELAVRIDLTEARVQVWFQNRRAKWRKQE 69

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Zebrafish
Match: arxa (aristaless related homeobox a [Source:NCBI gene;Acc:30657])

HSP 1 Score: 102.064 bits (253), Expect = 2.474e-23
Identity = 51/90 (56.67%), Postives = 62/90 (68.89%), Query Frame = 1

Query:  364 HNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            HN    ++ + +   S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  186 HNDGDVKDGEDSVCLSAGSDSEEGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 275

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Zebrafish
Match: arxb (aristaless related homeobox b [Source:ZFIN;Acc:ZDB-GENE-121109-2])

HSP 1 Score: 100.908 bits (250), Expect = 3.457e-23
Identity = 50/75 (66.67%), Postives = 55/75 (73.33%), Query Frame = 1

Query:  409 SINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            S  SDT   +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  148 SAGSDTEDGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 222

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Zebrafish
Match: rx1 (retinal homeobox gene 1 [Source:NCBI gene;Acc:30472])

HSP 1 Score: 99.3673 bits (246), Expect = 6.690e-23
Identity = 52/108 (48.15%), Postives = 70/108 (64.81%), Query Frame = 1

Query:  385 EYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAER-LLGFNNQIFYPNLQP 705
            E D+   +S + +  K+ K RR+RTTFT  Q+ +LERAF K  YPDV +REELA  ++L E RVQVWFQNRRAKWR+ E K   S+  + +  +L FN    +P + P
Sbjct:  119 ESDSKSPDSADGEQPKK-KHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQE-KIDASTMKLHDSPMLSFNRPSMHPTVGP 224

[Close]

Query:  385 EYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAER-LLGFNNQIFYPNLQP 705
            E D+   +S + +  K+ K RR+RTTFT  Q+ +LERAF K  YPDV +REELA  ++L E RVQVWFQNRRAKWR+ E K   S+  + +  +L FN    +P + P
Sbjct:  119 ESDSKSPDSADGEQPKK-KHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQE-KIDASTMKLHDSPMLSFNRPSMHPTVGP 224

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Zebrafish
Match: shox2 (short stature homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-040426-1457])

HSP 1 Score: 97.4413 bits (241), Expect = 1.961e-22
Identity = 54/121 (44.63%), Postives = 68/121 (56.20%), Query Frame = 1

Query:  298 SYLDRYGMKSDKIDENQMLNHTHNSDSS----------QEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKF 630
            S + R G++S  + E  ML    + DSS           +    D   +  +T  +IK RRSRT FT  Q+ +LER F +  YPD   REEL+  L LSEARVQVWFQNRRAK RK EN+ 
Sbjct:   50 SSITRSGVRSSPVREADMLASERSRDSSSPKLTDGNTDMKERKEDCKPLEDETQTKIKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQVWFQNRRAKCRKQENQL 170

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Xenopus
Match: ARX (aristaless related homeobox [Source:NCBI gene;Acc:100486727])

HSP 1 Score: 107.071 bits (266), Expect = 1.311e-24
Identity = 54/106 (50.94%), Postives = 71/106 (66.98%), Query Frame = 1

Query:  316 GMKSDKIDENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            G  ++   + +++ H+ ++D     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  257 GTDAELSPKEELMLHSSDADGKDGEDSVCL-SAGSDSEEGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 361

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Xenopus
Match: ENSXETT00000028778.1 (retina and anterior neural fold homeobox [Source:NCBI gene;Acc:100038124])

HSP 1 Score: 99.7525 bits (247), Expect = 5.951e-23
Identity = 59/136 (43.38%), Postives = 79/136 (58.09%), Query Frame = 1

Query:  271 EKLTDLKKESYLDRYGMKSDKIDENQMLNHTHNSDSSQEYDATDLNSINSDTNK-QIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFN 675
            E L D + + Y D Y  K+     +  L+ ++NSD          N ++ D  + + K RR+RTTFT  Q+ +LERAF K  YPDV +REELA  ++L E RVQVWFQNRRAKWR+ E    TS +     +L FN
Sbjct:   83 EHLEDGQSDGYGDPYSGKTSSECLSPGLSTSNNSD----------NKLSDDEQQPKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKLEVTSMKLQDSPILSFN 208

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Xenopus
Match: efna1 (ephrin-A1 [Source:Xenbase;Acc:XB-GENE-5942499])

HSP 1 Score: 100.908 bits (250), Expect = 1.033e-22
Identity = 54/115 (46.96%), Postives = 71/115 (61.74%), Query Frame = 1

Query:  376 SSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIP 720
            S +  + +D++S   D   + K RRSRTTFT  Q+++LERAF +  YPD+ TREELA    L+EARVQVWF NRRA+WRK         Q  A +L+ FN+ I  P   PP  +P
Sbjct:  200 SPESEEGSDIDS-EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRK---------QAGANQLMAFNHLI--PGAFPPAAMP 302

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Xenopus
Match: olfm3 (olfactomedin 3 [Source:Xenbase;Acc:XB-GENE-960616])

HSP 1 Score: 97.8265 bits (242), Expect = 4.857e-22
Identity = 57/116 (49.14%), Postives = 70/116 (60.34%), Query Frame = 1

Query:  292 KESYL----DRYGMKSDKIDENQMLNHTHNSDSSQEYDATDL--NSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            KES L    D  GM S  I   +          SQ+  + DL  +   S++NK  K RR+RTTFT  Q+++LE+ F K  YPDV  RE+LA   DL+EARVQVWFQNRRAKWRK E
Sbjct:  131 KESALTPNSDHQGMDSGYITSKETAG-----KGSQDRGSGDLPMDKTESESNKG-KKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRE 240

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Xenopus
Match: phox2a (paired like homeobox 2A [Source:NCBI gene;Acc:100486496])

HSP 1 Score: 96.2857 bits (238), Expect = 5.586e-22
Identity = 44/68 (64.71%), Postives = 55/68 (80.88%), Query Frame = 1

Query:  418 SDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            S  N++ K RR RTTFT SQ+++LER F++  YPD+ TREELA  +DL+EARVQVWFQNRRAK+RK E
Sbjct:   84 SGINEKRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQE 151

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BLAST of Aristaless related homeobox vs. Ensembl Mouse
Match: Arx (aristaless related homeobox [Source:MGI Symbol;Acc:MGI:1097716])

HSP 1 Score: 105.531 bits (262), Expect = 3.202e-24
Identity = 53/98 (54.08%), Postives = 67/98 (68.37%), Query Frame = 1

Query:  340 ENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            + ++L H  +++     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  294 KEELLLHPEDAEGKDGEDSVCL-SAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 390

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Query:  340 ENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            + ++L H  +++     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  294 KEELLLHPEDAEGKDGEDSVCL-SAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 390

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BLAST of Aristaless related homeobox vs. Ensembl Mouse
Match: Pax3 (paired box 3 [Source:MGI Symbol;Acc:MGI:97487])

HSP 1 Score: 100.523 bits (249), Expect = 1.117e-22
Identity = 54/120 (45.00%), Postives = 73/120 (60.83%), Query Frame = 1

Query:  361 THNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIP 720
            +  + + Q  + +D++S   D   + K RRSRTTFT  Q+++LERAF +  YPD+ TREELA    L+EARVQVWF NRRA+WRK         Q  A +L+ FN+ I  P   PP  +P
Sbjct:  193 SERASAPQSDEGSDIDS-EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRK---------QAGANQLMAFNHLI--PGGFPPTAMP 300

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BLAST of Aristaless related homeobox vs. Ensembl Mouse
Match: Pax3 (paired box 3 [Source:MGI Symbol;Acc:MGI:97487])

HSP 1 Score: 100.138 bits (248), Expect = 1.362e-22
Identity = 54/120 (45.00%), Postives = 73/120 (60.83%), Query Frame = 1

Query:  361 THNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIP 720
            +  + + Q  + +D++S   D   + K RRSRTTFT  Q+++LERAF +  YPD+ TREELA    L+EARVQVWF NRRA+WRK         Q  A +L+ FN+ I  P   PP  +P
Sbjct:  193 SERASAPQSDEGSDIDS-EPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRK---------QAGANQLMAFNHLI--PGGFPPTAMP 300

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BLAST of Aristaless related homeobox vs. Ensembl Mouse
Match: Alx4 (aristaless-like homeobox 4 [Source:MGI Symbol;Acc:MGI:108359])

HSP 1 Score: 95.1301 bits (235), Expect = 2.160e-21
Identity = 45/73 (61.64%), Postives = 55/73 (75.34%), Query Frame = 1

Query:  403 LNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            L   +S++NK  K RR+RTTFT  Q+++LE+ F K  YPDV  RE+LA   DL+EARVQVWFQNRRAKWRK E
Sbjct:  190 LEKTDSESNKG-KKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRE 261

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BLAST of Aristaless related homeobox vs. UniProt/SwissProt
Match: sp|Q96QS3|ARX_HUMAN (Homeobox protein ARX OS=Homo sapiens OX=9606 GN=ARX PE=1 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 1.177e-23
Identity = 53/98 (54.08%), Postives = 67/98 (68.37%), Query Frame = 1

Query:  340 ENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            + ++L H  +++     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  292 KEELLLHPEDAEGKDGEDSVCL-SAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 388

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BLAST of Aristaless related homeobox vs. UniProt/SwissProt
Match: sp|Q9I9A2|RX2_ORYLA (Retinal homeobox protein Rx2 OS=Oryzias latipes OX=8090 GN=rx2 PE=2 SV=1)

HSP 1 Score: 103.605 bits (257), Expect = 1.364e-23
Identity = 61/137 (44.53%), Postives = 83/137 (60.58%), Query Frame = 1

Query:  298 SYLDRYGMKSDKIDENQMLNHTHNSDSSQEYDATDLN--SINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAER-LLGFNNQIFYPNL 699
            SY D     SDK +E         S+ ++E D  D +  SI  + + + K RR+RTTFT  Q+ +LERAF K  YPDV +REELA+ ++L E RVQVWFQNRRAKWR+ E K  TS+  + +  +L FN     P++
Sbjct:   95 SYHDSSLFSSDKCEEM--------SNLTKEVDIADGSPKSIKEEEHGKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELATKVNLPEVRVQVWFQNRRAKWRRQE-KMDTSTMKLHDSPMLSFNRPPMPPSV 222

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BLAST of Aristaless related homeobox vs. UniProt/SwissProt
Match: sp|A6YP92|ARX_RAT (Homeobox protein ARX OS=Rattus norvegicus OX=10116 GN=Arx PE=2 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 1.439e-23
Identity = 53/98 (54.08%), Postives = 67/98 (68.37%), Query Frame = 1

Query:  340 ENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            + ++L H  +++     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  296 KEELLLHPEDAEGKDGEDSVCL-SAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 392

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BLAST of Aristaless related homeobox vs. UniProt/SwissProt
Match: sp|O35085|ARX_MOUSE (Homeobox protein ARX OS=Mus musculus OX=10090 GN=Arx PE=1 SV=3)

HSP 1 Score: 105.531 bits (262), Expect = 2.240e-23
Identity = 53/98 (54.08%), Postives = 67/98 (68.37%), Query Frame = 1

Query:  340 ENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            + ++L H  +++     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  294 KEELLLHPEDAEGKDGEDSVCL-SAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 390

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BLAST of Aristaless related homeobox vs. UniProt/SwissProt
Match: sp|O42115|ARX_DANRE (Aristaless-related homeobox protein OS=Danio rerio OX=7955 GN=arx PE=2 SV=1)

HSP 1 Score: 102.064 bits (253), Expect = 1.868e-22
Identity = 51/90 (56.67%), Postives = 62/90 (68.89%), Query Frame = 1

Query:  364 HNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            HN    ++ + +   S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  186 HNDGDVKDGEDSVCLSAGSDSEEGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 275

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BLAST of Aristaless related homeobox vs. TrEMBL
Match: Q17KG7 (AAEL001696-PA OS=Aedes aegypti OX=7159 GN=AAEL001696 PE=4 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 2.865e-25
Identity = 74/169 (43.79%), Postives = 92/169 (54.44%), Query Frame = 1

Query:  400 DLNSINSD---TNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE-------NKFSTSSQNIAERLLG--FNNQIFYPNLQPPFMIPQQNFIHGMNISEALTTLANKTSAIHANLIPPLNGVRLNPNSIPIFNDLPH 870
            DL+ ++ D    N+  K RRSRTTFT  Q+ +LERAF K QYPDV TREELA  LDLSEARVQVWFQNRRAKWRK E       + F    Q + E  LG    +Q+ +P+L PP      NF                   +H  LIP      ++PN +P +  +PH
Sbjct:   79 DLDGMDGDPNDMNRPRKIRRSRTTFTTFQLHQLERAFEKTQYPDVFTREELAMRLDLSEARVQVWFQNRRAKWRKREKAMGRDTSAFLHHDQGMPEFPLGLPLPHQLAHPSL-PPAEFWSANF------------------GLHPTLIPGSGHPLIHPNMVPSYK-IPH 227

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BLAST of Aristaless related homeobox vs. TrEMBL
Match: A0A4Y2EC28 (Homeobox protein ARX OS=Araneus ventricosus OX=182803 GN=Arx_1 PE=4 SV=1)

HSP 1 Score: 114.775 bits (286), Expect = 1.103e-24
Identity = 64/119 (53.78%), Postives = 76/119 (63.87%), Query Frame = 1

Query:  364 HNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNI---AERLLGFNNQI--FYPNLQP 705
            H  +S+++ D T  N   SD  ++I  RRSRTTFT  Q+ +LERAF K QYPDV TREELA  LDLSEARVQVWFQNRRAKWRK E      S N+    + L+G    +   YPN  P
Sbjct:  113 HPLESTEDGDGT--NGGGSDKPRKI--RRSRTTFTTYQLHQLERAFEKTQYPDVFTREELAMRLDLSEARVQVWFQNRRAKWRKREKAMGRDSPNLPSGVDLLMGPRTDLPPLYPNSGP 227

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BLAST of Aristaless related homeobox vs. TrEMBL
Match: B0X706 (Paired box protein OS=Culex quinquefasciatus OX=7176 GN=6048519 PE=4 SV=1)

HSP 1 Score: 112.464 bits (280), Expect = 3.384e-24
Identity = 72/169 (42.60%), Postives = 90/169 (53.25%), Query Frame = 1

Query:  400 DLNSINSDTN---KQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE-------NKFSTSSQNIAERLLG--FNNQIFYPNLQPPFMIPQQNFIHGMNISEALTTLANKTSAIHANLIPPLNGVRLNPNSIPIFNDLPH 870
            DL+ ++ D N   +  K RRSRTTFT  Q+ +LERAF K QYPDV TREELA  LDLSEARVQVWFQNRRAKWRK E       + F    Q + E  LG    +Q+ +P L PP      NF                   +H  L+P      ++P  +P +  +PH
Sbjct:  112 DLDGMDGDPNDMGRPRKIRRSRTTFTTFQLHQLERAFEKTQYPDVFTREELAMRLDLSEARVQVWFQNRRAKWRKREKAMGRDTSAFLHHDQGMPEFPLGLPLPHQLTHPGL-PPAEFWSANF------------------GLHPTLVPGSGHPLIHPTMVPNYK-IPH 260

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BLAST of Aristaless related homeobox vs. TrEMBL
Match: A7S2G7 (Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g165614 PE=3 SV=1)

HSP 1 Score: 108.997 bits (271), Expect = 4.528e-24
Identity = 55/87 (63.22%), Postives = 58/87 (66.67%), Query Frame = 1

Query:  391 DATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNI 651
            D +   S   D  K  K RRSRTTFT  Q+ +LERAF K QYPDV TREELA  LDLSEARVQVWFQNRRAKWRK E      S N 
Sbjct:    4 DGSGEESAGED-GKPRKVRRSRTTFTTYQLHQLERAFEKTQYPDVFTREELALRLDLSEARVQVWFQNRRAKWRKREKALGRESPNF 89

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BLAST of Aristaless related homeobox vs. TrEMBL
Match: A0A336M4L5 (CSON012079 protein OS=Culicoides sonorensis OX=179676 GN=CSON012079 PE=4 SV=1)

HSP 1 Score: 111.694 bits (278), Expect = 4.692e-24
Identity = 68/150 (45.33%), Postives = 82/150 (54.67%), Query Frame = 1

Query:  400 DLNSINSDTN-KQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIPQQNFIHGMNISEALTTLANKTSAIHANLIPPLNGVRLNPNSI 846
            DL++ + D N +  K RRSRTTFT  Q+ +LERAF K QYPDV TREELA  LDLSEARVQVWFQNRRAKWRK E      +        G       P+   P  +P     H +              ++H +LIPP N   L+PN I
Sbjct:   95 DLDNEHGDMNGRPRKIRRSRTTFTTYQLHQLERAFEKTQYPDVFTREELAMRLDLSEARVQVWFQNRRAKWRKREKAMGRDTSAFLHHEQGL------PDF--PLSLP---LAHNLGHPGIPAEFWPANFSLHPSLIPPSNHGLLHPNVI 233

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BLAST of Aristaless related homeobox vs. Ensembl Cavefish
Match: arxa (aristaless related homeobox [Source:NCBI gene;Acc:103042910])

HSP 1 Score: 103.219 bits (256), Expect = 8.673e-24
Identity = 50/90 (55.56%), Postives = 62/90 (68.89%), Query Frame = 1

Query:  364 HNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            H    +++ + +   S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  196 HGDGDAKDGEDSACLSAGSDSEEGVLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 285

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BLAST of Aristaless related homeobox vs. Ensembl Cavefish
Match: arxb (aristaless-related homeobox protein-like [Source:NCBI gene;Acc:103045700])

HSP 1 Score: 101.293 bits (251), Expect = 5.856e-23
Identity = 49/82 (59.76%), Postives = 56/82 (68.29%), Query Frame = 1

Query:  379 SQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
             +E       S   D  ++ K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  256 GEEGACFSAGSDAEDGTQKRKQRRYRTTFTSYQLEQLERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 337

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BLAST of Aristaless related homeobox vs. Ensembl Cavefish
Match: rx2 (retinal homeobox protein Rx2-like [Source:NCBI gene;Acc:103040507])

HSP 1 Score: 98.2117 bits (243), Expect = 1.206e-22
Identity = 50/90 (55.56%), Postives = 61/90 (67.78%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAER-LLGFNNQIFYPNLQP 705
            K RR+RTTFT  Q+ +LERAF K  YPDV +REELA  ++L E RVQVWFQNRRAKWR+ E K  TSS  + +  +L FN      N+ P
Sbjct:  137 KHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQE-KMDTSSMKLHDSPMLSFNRPPMPSNMGP 225

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BLAST of Aristaless related homeobox vs. Ensembl Cavefish
Match: phox2a (paired like homeobox 2A [Source:NCBI gene;Acc:103027382])

HSP 1 Score: 95.9005 bits (237), Expect = 4.259e-22
Identity = 44/68 (64.71%), Postives = 55/68 (80.88%), Query Frame = 1

Query:  418 SDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            S  N++ K RR RTTFT SQ+++LER F++  YPD+ TREELA  +DL+EARVQVWFQNRRAK+RK E
Sbjct:   81 SGLNEKRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQE 148

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BLAST of Aristaless related homeobox vs. Ensembl Cavefish
Match: rx1 (retinal homeobox protein Rx1-like [Source:NCBI gene;Acc:103032969])

HSP 1 Score: 96.6709 bits (239), Expect = 4.409e-22
Identity = 46/89 (51.69%), Postives = 60/89 (67.42%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQP 705
            K RR+RTTFT  Q+ +LERAF K  YPDV +REELA  ++L E RVQVWFQNRRAKWR+ E   +++ +     +L FN    + N+ P
Sbjct:  141 KHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKMDASAVKLHDSPMLSFNRPPMHTNVGP 229

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BLAST of Aristaless related homeobox vs. Ensembl Sea Lamprey
Match: dmbx1b (diencephalon/mesencephalon homeobox 1b [Source:NCBI gene;Acc:550288])

HSP 1 Score: 79.7221 bits (195), Expect = 8.713e-17
Identity = 36/62 (58.06%), Postives = 43/62 (69.35%), Query Frame = 1

Query:  445 RRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKF 630
            RRSRT FT  Q++ LE+ F K  YPDV  RE LA   +L EARVQVWF+NRRAK+RK +   
Sbjct:   44 RRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSL 105

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BLAST of Aristaless related homeobox vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010761.1 (pep scaffold:Pmarinus_7.0:GL476415:928307:936594:-1 gene:ENSPMAG00000009746.1 transcript:ENSPMAT00000010761.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 70.8626 bits (172), Expect = 7.711e-16
Identity = 35/58 (60.34%), Postives = 44/58 (75.86%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWR 612
            K RR RTTFT +Q+  LE  FSK +YPD+  REE+A  ++L E+RVQVWF+NRRAK R
Sbjct:    5 KQRRERTTFTRAQLDVLEALFSKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCR 62

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BLAST of Aristaless related homeobox vs. Ensembl Sea Lamprey
Match: barhl2 (BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050913-153])

HSP 1 Score: 63.929 bits (154), Expect = 5.791e-13
Identity = 28/60 (46.67%), Postives = 42/60 (70.00%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKH 618
            K R++RT F+  Q+ +LER+F + +Y  V  R ELAS L LS+ +V+ W+QNRR KW++ 
Sbjct:    4 KPRKARTAFSDHQLTQLERSFERQKYLSVQDRMELASSLSLSDTQVKTWYQNRRTKWKRQ 63

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Sea Lamprey
Match: barhl2 (BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050913-153])

HSP 1 Score: 64.3142 bits (155), Expect = 6.045e-13
Identity = 28/59 (47.46%), Postives = 42/59 (71.19%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRK 615
            K R++RT F+  Q+ +LER+F + +Y  V  R ELAS L LS+ +V+ W+QNRR KW++
Sbjct:    4 KPRKARTAFSDHQLTQLERSFERQKYLSVQDRMELASSLSLSDTQVKTWYQNRRTKWKR 62

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001141.1 (pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 gene:ENSPMAG00000001023.1 transcript:ENSPMAT00000001141.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 62.3882 bits (150), Expect = 1.283e-12
Identity = 28/59 (47.46%), Postives = 41/59 (69.49%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRK 615
            K RR RT F+  Q+ +LER FS+ +Y     R ++AS L L+E +V++WFQNRR KW++
Sbjct:    2 KCRRPRTAFSSQQLLELERHFSRQRYLSRPQRFQVASALMLTETQVKIWFQNRRMKWKR 60

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Yeast
Match: YHP1 (Homeobox transcriptional repressor; binds Mcm1p and early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval; YHP1 has a paralog, YOX1, that arose from the whole genome duplication [Source:SGD;Acc:S000002859])

HSP 1 Score: 50.0618 bits (118), Expect = 2.548e-7
Identity = 22/51 (43.14%), Postives = 33/51 (64.71%), Query Frame = 1

Query:  487 LERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTS 639
            L+ AF +C  P+   R EL+   ++SE  VQ+WFQN+R   +KH+N  +TS
Sbjct:  188 LQTAFDECPTPNKAKRIELSEQCNMSEKSVQIWFQNKRQAAKKHKNSGNTS 238

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Yeast
Match: PHO2 (Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000002264])

HSP 1 Score: 47.7506 bits (112), Expect = 2.272e-6
Identity = 21/59 (35.59%), Postives = 34/59 (57.63%), Query Frame = 1

Query:  445 RRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            R  RT   G  +  L+R F     P +  R++++ ++ + E  V++WFQNRRAK RK +
Sbjct:   78 RPKRTRAKGEALDVLKRKFEINPTPSLVERKKISDLIGMPEKNVRIWFQNRRAKLRKKQ 136

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Yeast
Match: YOX1 (Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication [Source:SGD;Acc:S000004489])

HSP 1 Score: 46.2098 bits (108), Expect = 4.685e-6
Identity = 20/59 (33.90%), Postives = 31/59 (52.54%), Query Frame = 1

Query:  442 SRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKH 618
            +RR R   +  ++  L+  F KC  P    R ELA    ++E  VQ+WFQN+R   ++ 
Sbjct:  176 ARRKRRRTSSQELSILQAEFEKCPAPSKEKRIELAESCHMTEKAVQIWFQNKRQAVKRQ 234

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Nematostella
Match: EDO42103 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S2G7])

HSP 1 Score: 108.997 bits (271), Expect = 6.261e-28
Identity = 55/87 (63.22%), Postives = 58/87 (66.67%), Query Frame = 1

Query:  391 DATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNI 651
            D +   S   D  K  K RRSRTTFT  Q+ +LERAF K QYPDV TREELA  LDLSEARVQVWFQNRRAKWRK E      S N 
Sbjct:    4 DGSGEESAGED-GKPRKVRRSRTTFTTYQLHQLERAFEKTQYPDVFTREELALRLDLSEARVQVWFQNRRAKWRKREKALGRESPNF 89

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Nematostella
Match: EDO31796 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWY2])

HSP 1 Score: 93.5893 bits (231), Expect = 1.225e-23
Identity = 52/90 (57.78%), Postives = 64/90 (71.11%), Query Frame = 1

Query:  361 THNSDSSQ-EYDATDLNSI--NSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            T NSD  + + +A D N+     D+  + K RR RTTFT  Q+++LERAF+K  YPDV TRE LA  +DL+EARVQVWFQNRRAKWRK E
Sbjct:    1 TRNSDDEKSDEEAVDSNNELEGKDSTAKRKQRRYRTTFTSYQLEELERAFAKTHYPDVFTREALAVKIDLTEARVQVWFQNRRAKWRKRE 90

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Nematostella
Match: EDO38926 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBH9])

HSP 1 Score: 94.7449 bits (234), Expect = 4.417e-23
Identity = 48/101 (47.52%), Postives = 65/101 (64.36%), Query Frame = 1

Query:  403 LNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQP 705
            ++S + D+  + K RR+RTTFT  Q++++ER F K  YPDV TRE+LA    L+EARVQVWFQNRRAKWRK E +F+     +   + G      Y  +QP
Sbjct:    1 MDSDSGDSAPKRKKRRNRTTFTAYQLEEMERVFQKTHYPDVYTREQLALRCALTEARVQVWFQNRRAKWRKRE-RFT----QVPVPVRGMGPTSIYDQIQP 96

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Nematostella
Match: EDO47151 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMS9])

HSP 1 Score: 88.9669 bits (219), Expect = 3.089e-22
Identity = 39/59 (66.10%), Postives = 49/59 (83.05%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRK 615
            K RR+RTTFT  Q+Q+LE+ F K  YPD+  REELA+ +++SEAR+QVWFQNRRAKWRK
Sbjct:   15 KQRRNRTTFTKQQLQELEKVFEKKHYPDIALREELAAKINISEARIQVWFQNRRAKWRK 73

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Nematostella
Match: EDO42147 (Predicted protein; Retinal homeobox [Source:UniProtKB/TrEMBL;Acc:A7S2G8])

HSP 1 Score: 93.5893 bits (231), Expect = 6.774e-22
Identity = 53/119 (44.54%), Postives = 71/119 (59.66%), Query Frame = 1

Query:  367 NSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNI--AERLLGFNNQIFYPNLQPPFMI 717
            NSD+    +    +  + D++K+ K RR+RTTFT  Q+ +LERAF K  YPDV TREELA  + L E RVQVWFQN+RAKWR+ E     S Q++    R  GF +  F    + P  +
Sbjct:   61 NSDNDLSSNDGKSDEADGDSSKK-KLRRNRTTFTTFQLHELERAFEKSHYPDVYTREELALKISLPEVRVQVWFQNKRAKWRREEKMEMASLQDLPSPSRTSGFGSLTFSDMWKNPLTL 178

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Medaka
Match: rx2 (Rx2 transcription factor [Source:NCBI gene;Acc:100125458])

HSP 1 Score: 103.605 bits (257), Expect = 1.521e-24
Identity = 61/137 (44.53%), Postives = 83/137 (60.58%), Query Frame = 1

Query:  298 SYLDRYGMKSDKIDENQMLNHTHNSDSSQEYDATDLN--SINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAER-LLGFNNQIFYPNL 699
            SY D     SDK +E         S+ ++E D  D +  SI  + + + K RR+RTTFT  Q+ +LERAF K  YPDV +REELA+ ++L E RVQVWFQNRRAKWR+ E K  TS+  + +  +L FN     P++
Sbjct:   95 SYHDSSLFSSDKCEEM--------SNLTKEVDIADGSPKSIKEEEHGKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELATKVNLPEVRVQVWFQNRRAKWRRQE-KMDTSTMKLHDSPMLSFNRPPMPPSV 222

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Medaka
Match: arx (aristaless related homeobox [Source:NCBI gene;Acc:100144363])

HSP 1 Score: 103.219 bits (256), Expect = 1.024e-23
Identity = 57/103 (55.34%), Postives = 68/103 (66.02%), Query Frame = 1

Query:  325 SDKIDENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            S K +E + LN   + D     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  182 SPKDEEREGLN-AGDGDVRDGEDSVCL-SAGSDSEEGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 282

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Medaka
Match: arx (aristaless related homeobox [Source:NCBI gene;Acc:100144363])

HSP 1 Score: 102.834 bits (255), Expect = 1.755e-23
Identity = 57/103 (55.34%), Postives = 68/103 (66.02%), Query Frame = 1

Query:  325 SDKIDENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            S K +E + LN   + D     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  182 SPKDEEREGLN-AGDGDVRDGEDSVCL-SAGSDSEEGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 282

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Medaka
Match: arx (aristaless related homeobox [Source:NCBI gene;Acc:100144363])

HSP 1 Score: 102.834 bits (255), Expect = 1.865e-23
Identity = 57/103 (55.34%), Postives = 68/103 (66.02%), Query Frame = 1

Query:  325 SDKIDENQMLNHTHNSDSSQEYDATDLNSINSDTNKQI---KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHEN 624
            S K +E + LN   + D     D+  L S  SD+ + +   K RR RTTFT  Q+++LERAF K  YPDV TREELA  LDL+EARVQVWFQNRRAKWRK E 
Sbjct:  182 SPKDEEREGLN-AGDGDVRDGEDSVCL-SAGSDSEEGMLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREK 282

[Close]

BLAST of Aristaless related homeobox vs. Ensembl Medaka
Match: pax7 (paired box 7 [Source:NCBI gene;Acc:101174017])

HSP 1 Score: 99.7525 bits (247), Expect = 1.566e-22
Identity = 59/155 (38.06%), Postives = 85/155 (54.84%), Query Frame = 1

Query:  271 EKLTDLKKE-----SYLDRYGMKSDKIDENQMLNHTHNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIP 720
            +++ + K+E     S+  R  +  D + +   +     S  S+  D +D++S   D   + K RRSRTTFT  Q+++LE+AF +  YPD+ TREELA    L+EARVQVWF NRRA+WRK         Q  A +L  FN+    P   PP  +P
Sbjct:  117 KRIEEYKRENPGMFSWEIRDKLLKDGVCDRSTVPSGEASSGSRTDDGSDVDS-EPDLPLKRKQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRK---------QAGANQLAAFNH--LLPGGFPPTGMP 259

[Close]

BLAST of Aristaless related homeobox vs. Planmine SMEST
Match: SMESG000017304.1 (SMESG000017304.1)

HSP 1 Score: 613.994 bits (1582), Expect = 0.000e+0
Identity = 309/313 (98.72%), Postives = 312/313 (99.68%), Query Frame = 1

Query:  217 MAGKSFHIESLQLDSYHSEKLTDLKKESYLDRYGMKSDKIDENQMLNHTHNSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIPQQNFIHGMNISEALTTLANKTSAIHANLIPPLNGVRLNPNSIPIFNDLPHXXXXXXXXXIHTSTKIPSPISGTSQMPISCYSTPNFRDKSFMDSPVNVGSSFPQIIFNKNLISPINNSNNFPKSDPHIPFLSAPSDLSLSVESTK 1155
            MAGKSFHIESLQLDSYHSEKLTDLKKESYLDRYGMK DKIDENQMLNHTHNSDSSQEYDAT++NS+NSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIPQQNFIHGMNISEALTTLANKTSAIHANLIPPLNGVRLNPNSIPIFNDLPHSQLLSLLSSIHTSTKIPSPISGTSQMPISCYSTPNFRDKSFMDSPVNVGSSFPQIIFNKNLISPINNSNNFPKSDPHIPFLSAPSDLSLSVESTK
Sbjct:    1 MAGKSFHIESLQLDSYHSEKLTDLKKESYLDRYGMKIDKIDENQMLNHTHNSDSSQEYDATEVNSMNSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPNLQPPFMIPQQNFIHGMNISEALTTLANKTSAIHANLIPPLNGVRLNPNSIPIFNDLPHSQLLSLLSSIHTSTKIPSPISGTSQMPISCYSTPNFRDKSFMDSPVNVGSSFPQIIFNKNLISPINNSNNFPKSDPHIPFLSAPSDLSLSVESTK 313

[Close]

BLAST of Aristaless related homeobox vs. Planmine SMEST
Match: SMESG000052478.1 (SMESG000052478.1)

HSP 1 Score: 96.6709 bits (239), Expect = 5.209e-22
Identity = 46/85 (54.12%), Postives = 64/85 (75.29%), Query Frame = 1

Query:  367 NSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHE 621
            NS+S + Y +     I ++ N++ K RR RTTFT +Q+++LER+F +  YPD+ TREE+A  +DL+EARVQVWFQNRRAK+RK E
Sbjct:  201 NSNSYKLYSSPVDADIVTNINEKRKQRRIRTTFTSAQLKELERSFQETHYPDIYTREEIAMKIDLTEARVQVWFQNRRAKFRKME 285

[Close]

BLAST of Aristaless related homeobox vs. Planmine SMEST
Match: SMESG000080420.1 (SMESG000080420.1)

HSP 1 Score: 95.9005 bits (237), Expect = 1.288e-21
Identity = 50/86 (58.14%), Postives = 60/86 (69.77%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPN 696
            K RR+RTTFT  Q+++LE+AF +  YPDV TREELA  + L+EARVQVWFQNRRAKWRK E +F    QN      G N+Q F  N
Sbjct:   36 KQRRNRTTFTMQQLEELEKAFQQTHYPDVFTREELALRISLTEARVQVWFQNRRAKWRKTE-RFQPLQQNS-----GINDQHFRSN 115

[Close]

BLAST of Aristaless related homeobox vs. Planmine SMEST
Match: SMESG000080420.1 (SMESG000080420.1)

HSP 1 Score: 95.5153 bits (236), Expect = 1.450e-21
Identity = 50/86 (58.14%), Postives = 60/86 (69.77%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPN 696
            K RR+RTTFT  Q+++LE+AF +  YPDV TREELA  + L+EARVQVWFQNRRAKWRK E +F    QN      G N+Q F  N
Sbjct:   29 KQRRNRTTFTMQQLEELEKAFQQTHYPDVFTREELALRISLTEARVQVWFQNRRAKWRKTE-RFQPLQQNS-----GINDQHFRSN 108

[Close]

BLAST of Aristaless related homeobox vs. Planmine SMEST
Match: SMESG000080420.1 (SMESG000080420.1)

HSP 1 Score: 95.9005 bits (237), Expect = 2.273e-21
Identity = 50/86 (58.14%), Postives = 60/86 (69.77%), Query Frame = 1

Query:  439 KSRRSRTTFTGSQIQKLERAFSKCQYPDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLLGFNNQIFYPN 696
            K RR+RTTFT  Q+++LE+AF +  YPDV TREELA  + L+EARVQVWFQNRRAKWRK E +F    QN      G N+Q F  N
Sbjct:  140 KQRRNRTTFTMQQLEELEKAFQQTHYPDVFTREELALRISLTEARVQVWFQNRRAKWRKTE-RFQPLQQNS-----GINDQHFRSN 219

The following BLAST results are available for this feature:

BLAST of Aristaless related homeobox vs. Ensembl Human
BLAST of Aristaless related homeobox vs. Ensembl Celegans
BLAST of Aristaless related homeobox vs. Ensembl Fly
BLAST of Aristaless related homeobox vs. Ensembl Zebrafish
BLAST of Aristaless related homeobox vs. Ensembl Xenopus
BLAST of Aristaless related homeobox vs. Ensembl Mouse
BLAST of Aristaless related homeobox vs. UniProt/SwissProt
BLAST of Aristaless related homeobox vs. TrEMBL
BLAST of Aristaless related homeobox vs. Ensembl Cavefish
BLAST of Aristaless related homeobox vs. Ensembl Sea Lamprey
BLAST of Aristaless related homeobox vs. Ensembl Yeast
BLAST of Aristaless related homeobox vs. Ensembl Nematostella
BLAST of Aristaless related homeobox vs. Ensembl Medaka
BLAST of Aristaless related homeobox vs. Planmine SMEST

BLAST of Aristaless related homeobox vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ARX	2.451e-24	54.08	aristaless related homeobox [Source:HGNC Symbol;Ac...	[more]
PAX3	1.218e-22	45.00	paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617]	[more]
PAX3	1.353e-22	45.00	paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617]	[more]
PAX3	1.500e-22	45.00	paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617]	[more]
PAX3	1.567e-22	45.00	paired box 3 [Source:HGNC Symbol;Acc:HGNC:8617]	[more]

BLAST of Aristaless related homeobox vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ceh-17	2.966e-21	65.57	C. Elegans Homeobox; CEH-17 [Source:UniProtKB/TrE...	[more]
unc-4	8.233e-21	52.87	Homeobox protein unc-4 [Source:UniProtKB/Swiss-Pr...	[more]
alr-1	1.421e-20	61.19	AristaLess (Drosophila homeodomain) Related [Sour...	[more]
unc-42	1.622e-20	58.67	pep chromosome:WBcel235:V:9764645:9767679:-1 gene:...	[more]
unc-42	2.429e-20	58.67	pep chromosome:WBcel235:V:9764645:9769361:-1 gene:...	[more]

BLAST of Aristaless related homeobox vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hbn	9.269e-25	73.53	gene:FBgn0008636 transcript:FBtr0071556	[more]
Rx	3.401e-22	41.79	gene:FBgn0020617 transcript:FBtr0342783	[more]
gsb-n	8.513e-22	46.22	gene:FBgn0001147 transcript:FBtr0072461	[more]
al	1.020e-21	68.85	gene:FBgn0000061 transcript:FBtr0078053	[more]
Pph13	1.371e-21	70.49	gene:FBgn0023489 transcript:FBtr0078070	[more]

BLAST of Aristaless related homeobox vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
arxa	2.474e-23	56.67	aristaless related homeobox a [Source:NCBI gene;Ac...	[more]
arxb	3.457e-23	66.67	aristaless related homeobox b [Source:ZFIN;Acc:ZDB...	[more]
rx1	6.690e-23	48.15	retinal homeobox gene 1 [Source:NCBI gene;Acc:3047...	[more]
rx1	6.690e-23	48.15	retinal homeobox gene 1 [Source:NCBI gene;Acc:3047...	[more]
shox2	1.961e-22	44.63	short stature homeobox 2 [Source:ZFIN;Acc:ZDB-GENE...	[more]

BLAST of Aristaless related homeobox vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ARX	1.311e-24	50.94	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
ENSXETT00000028778.1	5.951e-23	43.38	retina and anterior neural fold homeobox [Source:N...	[more]
efna1	1.033e-22	46.96	ephrin-A1 [Source:Xenbase;Acc:XB-GENE-5942499]	[more]
olfm3	4.857e-22	49.14	olfactomedin 3 [Source:Xenbase;Acc:XB-GENE-960616]	[more]
phox2a	5.586e-22	64.71	paired like homeobox 2A [Source:NCBI gene;Acc:1004...	[more]

BLAST of Aristaless related homeobox vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Arx	3.202e-24	54.08	aristaless related homeobox [Source:MGI Symbol;Acc...	[more]
Arx	3.202e-24	54.08	aristaless related homeobox [Source:MGI Symbol;Acc...	[more]
Pax3	1.117e-22	45.00	paired box 3 [Source:MGI Symbol;Acc:MGI:97487]	[more]
Pax3	1.362e-22	45.00	paired box 3 [Source:MGI Symbol;Acc:MGI:97487]	[more]
Alx4	2.160e-21	61.64	aristaless-like homeobox 4 [Source:MGI Symbol;Acc:...	[more]

BLAST of Aristaless related homeobox vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q96QS3\|ARX_HUMAN	1.177e-23	54.08	Homeobox protein ARX OS=Homo sapiens OX=9606 GN=AR...	[more]
sp\|Q9I9A2\|RX2_ORYLA	1.364e-23	44.53	Retinal homeobox protein Rx2 OS=Oryzias latipes OX...	[more]
sp\|A6YP92\|ARX_RAT	1.439e-23	54.08	Homeobox protein ARX OS=Rattus norvegicus OX=10116...	[more]
sp\|O35085\|ARX_MOUSE	2.240e-23	54.08	Homeobox protein ARX OS=Mus musculus OX=10090 GN=A...	[more]
sp\|O42115\|ARX_DANRE	1.868e-22	56.67	Aristaless-related homeobox protein OS=Danio rerio...	[more]

BLAST of Aristaless related homeobox vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
Q17KG7	2.865e-25	43.79	AAEL001696-PA OS=Aedes aegypti OX=7159 GN=AAEL0016...	[more]
A0A4Y2EC28	1.103e-24	53.78	Homeobox protein ARX OS=Araneus ventricosus OX=182...	[more]
B0X706	3.384e-24	42.60	Paired box protein OS=Culex quinquefasciatus OX=71...	[more]
A7S2G7	4.528e-24	63.22	Predicted protein OS=Nematostella vectensis OX=453...	[more]
A0A336M4L5	4.692e-24	45.33	CSON012079 protein OS=Culicoides sonorensis OX=179...	[more]

BLAST of Aristaless related homeobox vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
arxa	8.673e-24	55.56	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
arxb	5.856e-23	59.76	aristaless-related homeobox protein-like [Source:N...	[more]
rx2	1.206e-22	55.56	retinal homeobox protein Rx2-like [Source:NCBI gen...	[more]
phox2a	4.259e-22	64.71	paired like homeobox 2A [Source:NCBI gene;Acc:1030...	[more]
rx1	4.409e-22	51.69	retinal homeobox protein Rx1-like [Source:NCBI gen...	[more]

BLAST of Aristaless related homeobox vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dmbx1b	8.713e-17	58.06	diencephalon/mesencephalon homeobox 1b [Source:NCB...	[more]
ENSPMAT00000010761.1	7.711e-16	60.34	pep scaffold:Pmarinus_7.0:GL476415:928307:936594:-...	[more]
barhl2	5.791e-13	46.67	BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050...	[more]
barhl2	6.045e-13	47.46	BarH-like homeobox 2 [Source:ZFIN;Acc:ZDB-GENE-050...	[more]
ENSPMAT00000001141.1	1.283e-12	47.46	pep scaffold:Pmarinus_7.0:GL478075:36995:38394:-1 ...	[more]

BLAST of Aristaless related homeobox vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
YHP1	2.548e-7	43.14	Homeobox transcriptional repressor; binds Mcm1p an...	[more]
PHO2	2.272e-6	35.59	Homeobox transcription factor; regulatory targets ...	[more]
YOX1	4.685e-6	33.90	Homeobox transcriptional repressor; binds to Mcm1p...	[more]

BLAST of Aristaless related homeobox vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO42103	6.261e-28	63.22	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31796	1.225e-23	57.78	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38926	4.417e-23	47.52	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47151	3.089e-22	66.10	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42147	6.774e-22	44.54	Predicted protein; Retinal homeobox [Source:UniPr...	[more]

BLAST of Aristaless related homeobox vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
rx2	1.521e-24	44.53	Rx2 transcription factor [Source:NCBI gene;Acc:100...	[more]
arx	1.024e-23	55.34	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
arx	1.755e-23	55.34	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
arx	1.865e-23	55.34	aristaless related homeobox [Source:NCBI gene;Acc:...	[more]
pax7	1.566e-22	38.06	paired box 7 [Source:NCBI gene;Acc:101174017]	[more]

BLAST of Aristaless related homeobox vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000017304.1	0.000e+0	98.72	SMESG000017304.1	[more]
SMESG000052478.1	5.209e-22	54.12	SMESG000052478.1	[more]
SMESG000080420.1	1.288e-21	58.14	SMESG000080420.1	[more]
SMESG000080420.1	1.450e-21	58.14	SMESG000080420.1	[more]
SMESG000080420.1	2.273e-21	58.14	SMESG000080420.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30029943 ID=SMED30029943|Name=Aristaless related homeobox|organism=Schmidtea mediterranea sexual|type=transcript|length=1189bp
AAAATCAACTCAAGAGCATTTTACGATTGAATTACATTAATTAAAACCAA
TAAACGAATCAATTTACAGCAATCAAGCGCAATTACTGATAACTGCATTC
CTATTGGTTGTCGAATTAAAATTGAAAAGCCAATGATTTTATTATCTATA
AAATCTATAATCTTTTATAATGAGCTCAGTTAAATCAATTAATTAAATTT
TTATTGAGATAATAAAATGGCCGGAAAATCTTTTCATATAGAAAGTTTAC
AATTGGATTCATATCATTCAGAGAAATTAACAGATCTTAAAAAGGAATCG
TATTTGGATAGATATGGAATGAAAAGTGATAAAATCGACGAAAACCAAAT
GTTGAATCATACTCACAATTCTGACAGCAGTCAAGAATACGATGCGACAG
ATCTCAACAGTATCAACAGTGACACAAACAAACAAATCAAATCCCGAAGA
TCCCGAACGACATTCACAGGGAGTCAAATTCAGAAACTTGAGAGAGCATT
CAGCAAATGCCAATATCCTGACGTCAACACCCGAGAAGAATTAGCATCAA
TTTTAGATCTCAGTGAAGCTCGTGTTCAGGTTTGGTTTCAAAATCGCCGA
GCAAAATGGCGAAAGCACGAAAACAAATTTTCAACGTCCAGCCAAAATAT
CGCCGAACGTCTTTTGGGATTCAACAATCAAATTTTCTATCCAAATCTCC
AACCGCCATTCATGATACCCCAGCAGAACTTCATCCATGGCATGAACATT
TCCGAAGCTCTCACAACTCTGGCCAACAAAACCTCAGCGATCCACGCAAA
TCTAATCCCCCCGCTAAATGGTGTTCGATTAAATCCTAATTCAATTCCGA
TTTTCAACGATTTGCCACACAGTCAACTTCTTTCTCTTCTCTCTTCCATT
CATACTTCTACAAAAATTCCTTCCCCGATAAGCGGCACTTCTCAAATGCC
AATCAGCTGTTATTCGACTCCGAATTTCCGTGACAAGTCCTTCATGGATT
CCCCAGTGAATGTTGGATCTTCGTTTCCCCAAATAATTTTCAACAAAAAT
CTCATATCACCAATCAACAACTCGAACAATTTCCCAAAATCAGATCCTCA
CATACCTTTTCTTTCAGCTCCGTCTGATTTATCTCTGTCAGTAGAATCAA
CAAAATAGAACATTAGTTAAATAAATTCTTTCATTCTTG

protein sequence of SMED30029943-orf-1

>SMED30029943-orf-1 ID=SMED30029943-orf-1|Name=SMED30029943-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=314bp
MAGKSFHIESLQLDSYHSEKLTDLKKESYLDRYGMKSDKIDENQMLNHTH
NSDSSQEYDATDLNSINSDTNKQIKSRRSRTTFTGSQIQKLERAFSKCQY
PDVNTREELASILDLSEARVQVWFQNRRAKWRKHENKFSTSSQNIAERLL
GFNNQIFYPNLQPPFMIPQQNFIHGMNISEALTTLANKTSAIHANLIPPL
NGVRLNPNSIPIFNDLPHSQLLSLLSSIHTSTKIPSPISGTSQMPISCYS
TPNFRDKSFMDSPVNVGSSFPQIIFNKNLISPINNSNNFPKSDPHIPFLS
APSDLSLSVESTK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organism development

Vocabulary: **INTERPRO**
Term	Definition
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 76..138 e-value: 4.5E-28 score: 109.3
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 77..133 e-value: 2.2E-24 score: 85.0
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 74..134 score: 20.811
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 77..135 e-value: 6.84105E-25 score: 93.0768
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 61..138 e-value: 8.7E-30 score: 104.2
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 51..81
None	No IPR available	PANTHER	PTHR24329	FAMILY NOT NAMED	coord: 44..225
None	No IPR available	PANTHER	PTHR24329:SF521	HOMEOBOX PROTEIN ARX	coord: 44..225
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 109..132
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 71..138