1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase

Overview


Name	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
Smed ID	SMED30029890
Length (bp)	5190

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (SMED30029890) t-SNE clustered cells

Violin plots show distribution of expression levels for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (SMED30029890) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase (SMED30029890) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30029890

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 12

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30029890	SMESG000024212.1	SmedASXL_015064	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
pharynx	SMED30029890	SMESG000024212.1 SMESG000033570.1	dd_Smed_v4_9324_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30029890	SMESG000024212.1 SMESG000033570.1	dd_Smed_v4_9324_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30029890	SMESG000024212.1 SMESG000033570.1	dd_Smed_v4_9324_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30029890	SMESG000024212.1 SMESG000033570.1	dd_Smed_v4_9324_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30029890	SMESG000024212.1 SMESG000033570.1	dd_Smed_v4_9324_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30029890	SMESG000024212.1 SMESG000033570.1	dd_Smed_v4_9324_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30029890	SMESG000024212.1 SMESG000033570.1	dd_Smed_v4_9324_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30029890	SMESG000024212.1	Contig35486	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30029890	SMESG000024212.1	Contig35486	newmark_ests	PMID:29674431 Fincher et al., 2018
head region	SMED30029890	SMESG000024212.1 SMESG000033570.1	dd_Smed_v6_9324_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
head region	SMED30029890	SMESG000024212.1	OX_Smed_1.0.10847	ox_Smed_v2	PMID:24238224 Kao et al., 2013

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Human
Match: PLCB4 (phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGNC:9059])

HSP 1 Score: 595.504 bits (1534), Expect = 0.000e+0
Identity = 272/476 (57.14%), Postives = 357/476 (75.00%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+W+SE  E  V +  LI+ ++SG   KD K+L+ L+   K+++++E R + +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  + N N KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ F++EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G  LPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 558.14 bits (1437), Expect = 3.264e-173
Identity = 297/614 (48.37%), Postives = 408/614 (66.45%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRS---IQEMLS--------LTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S V                 +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK       ++M + +   IQ + S        +  ++ +E +++   H   EQ ++ L+  Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANTAKANVTPQSSSELR-----PTTTAALASGV-----------------EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1131

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Human
Match: PLCB4 (phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGNC:9059])

HSP 1 Score: 595.119 bits (1533), Expect = 0.000e+0
Identity = 272/476 (57.14%), Postives = 357/476 (75.00%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+W+SE  E  V +  LI+ ++SG   KD K+L+ L+   K+++++E R + +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  + N N KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ F++EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G  LPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 558.525 bits (1438), Expect = 2.375e-173
Identity = 297/614 (48.37%), Postives = 408/614 (66.45%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRS---IQEMLS--------LTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S V                 +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK       ++M + +   IQ + S        +  ++ +E +++   H   EQ ++ L+  Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  555 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANTAKANVTPQSSSELR-----PTTTAALASGV-----------------EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1143

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Human
Match: PLCB4 (phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGNC:9059])

HSP 1 Score: 595.119 bits (1533), Expect = 0.000e+0
Identity = 272/476 (57.14%), Postives = 357/476 (75.00%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+W+SE  E  V +  LI+ ++SG   KD K+L+ L+   K+++++E R + +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  + N N KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ F++EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G  LPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 558.525 bits (1438), Expect = 2.375e-173
Identity = 297/614 (48.37%), Postives = 408/614 (66.45%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRS---IQEMLS--------LTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S V                 +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK       ++M + +   IQ + S        +  ++ +E +++   H   EQ ++ L+  Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  555 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANTAKANVTPQSSSELR-----PTTTAALASGV-----------------EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1143

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Human
Match: PLCB4 (phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGNC:9059])

HSP 1 Score: 594.734 bits (1532), Expect = 0.000e+0
Identity = 272/476 (57.14%), Postives = 357/476 (75.00%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+W+SE  E  V +  LI+ ++SG   KD K+L+ L+   K+++++E R + +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  + N N KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ F++EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G  LPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 558.14 bits (1437), Expect = 2.137e-173
Identity = 297/614 (48.37%), Postives = 408/614 (66.45%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRS---IQEMLS--------LTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S V                 +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK       ++M + +   IQ + S        +  ++ +E +++   H   EQ ++ L+  Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANTAKANVTPQSSSELR-----PTTTAALASGV-----------------EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1131

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Human
Match: PLCB4 (phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGNC:9059])

HSP 1 Score: 594.734 bits (1532), Expect = 0.000e+0
Identity = 272/476 (57.14%), Postives = 357/476 (75.00%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+W+SE  E  V +  LI+ ++SG   KD K+L+ L+   K+++++E R + +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  + N N KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ F++EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G  LPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 558.14 bits (1437), Expect = 2.137e-173
Identity = 297/614 (48.37%), Postives = 408/614 (66.45%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRS---IQEMLS--------LTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S V                 +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK       ++M + +   IQ + S        +  ++ +E +++   H   EQ ++ L+  Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANTAKANVTPQSSSELR-----PTTTAALASGV-----------------EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1131

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Celegans
Match: egl-8 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Source:UniProtKB/Swiss-Prot;Acc:G5EBH0])

HSP 1 Score: 933.324 bits (2411), Expect = 0.000e+0
Identity = 495/1072 (46.18%), Postives = 699/1072 (65.21%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQS-NIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKT-ADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQ-EPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKK--YLHEKKSSAKDLTSLMVGDESAE-----IEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSS-LFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQST-DGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKL 3460
            +K ++F W+  I  EL  G++FD YDDE   LE+N  V++DE GFFL W  E  +A V DM  I + ++G   KD +++ +L+ +  S  I +RT+ I+   D VN+ +   + +  ++       +  +  + +  ++CP TQL K+   L + VN   KIP+KL+ KTF+SG+ EK+V + L +L L  +K   ++D    TFEKF  L N ICPRT++Q+LF  LS  K+YLT +R+I FLNE QRDPRLNEIL+P+ +   +  +L  +E +   +  G++S D F R+LMSDEN PVFLDR+++  DMDQPL HYYINSSHNTYLTGRQ+ GKSS ++YRQVLL+GCRC+ELDCWDG G+++ EPIITHGKAMC+D+ F+DV+  IRD AF  S +PV LSFENHCSK  Q K+AKYC ++ G+ LL+KP E   L+ GV LPSP +L+ KILIKNKRL  + E+ QLD FL+ +  L ++ E+ E P+++  +  +   + ++++D+   + +       LK +    SK+   S +S +  +P  +S+ +  +       +++ +    ME S +E     + K   +  E  S +  L   M    S +      +++++ +   Y +T  TTN+HP LSSLVNY  PVKF GF++       FHMSSFSE+  LG++K  A E VNYNK Q SRIYP+G RVDSSNFLPQIFWNAGCQMV+LNFQ+ D+ MQLN G+FEYN  SGY+LKP+F+RR +R FDPFSESP+DGVIAA C V++ISGQFLS++KIGTYVEV+MYGLPTDTIRKE +T+V+P NGLNP+Y ED  FVFRKV+LP+LAVLR  V++E GK +GQR+LPLDGLQ G+RHISLRS+ N    LS  LF +I + TYVPD  +  VDAL+DPRA +S ++ + + +A+MG + S+I D+ P+T ++  +  K+   +  S+ D   +N + G  +   T+ + S+     +R+ N    P     FK D I  E+  + L   K   K LKR  KE  +L+K+  K+ + + K    + +KL
Sbjct:    2 AKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLR-EGKLDEEDELNETPEVVGEDSVSPREMPAKENDEAHPELKQNFIAKNLKGFGF--SKKQPDSSTSLLTASPTPSSSSMAMSNANNPFSSSTLNSPQPMERSRSEKRSFRQKKGGVFGDELHSDSAALIDFMRTASSRKKKPVLTKEEEERIFAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDP-FVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDV-PNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASST----IRSPNEQPQPVAVDKFKVDPI--EV--DDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQKQQQTNVDKL 1060

HSP 2 Score: 56.6102 bits (135), Expect = 1.784e-7
Identity = 30/80 (37.50%), Postives = 49/80 (61.25%), Query Frame = 2

Query: 3671 KVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            K++S+ Q  Q   L+L  + E K++   QTK SME  +++  D   + KAERDRR++EL + N K F+++R+   MK  +
Sbjct: 1183 KLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQK 1262

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Celegans
Match: egl-8 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Source:UniProtKB/Swiss-Prot;Acc:G5EBH0])

HSP 1 Score: 930.628 bits (2404), Expect = 0.000e+0
Identity = 493/1063 (46.38%), Postives = 695/1063 (65.38%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQS-NIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKT-ADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQ-EPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKK--YLHEKKSSAKDLTSLMVGDESAE-----IEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSS-LFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQST-DGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLK 3433
            +K ++F W+  I  EL  G++FD YDDE   LE+N  V++DE GFFL W  E  +A V DM  I + ++G   KD +++ +L+ +  S  I +RT+ I+   D VN+ +   + +  ++       +  +  + +  ++CP TQL K+   L + VN   KIP+KL+ KTF+SG+ EK+V + L +L L  +K   ++D    TFEKF  L N ICPRT++Q+LF  LS  K+YLT +R+I FLNE QRDPRLNEIL+P+ +   +  +L  +E +   +  G++S D F R+LMSDEN PVFLDR+++  DMDQPL HYYINSSHNTYLTGRQ+ GKSS ++YRQVLL+GCRC+ELDCWDG G+++ EPIITHGKAMC+D+ F+DV+  IRD AF  S +PV LSFENHCSK  Q K+AKYC ++ G+ LL+KP E   L+ GV LPSP +L+ KILIKNKRL  + E+ QLD FL+ +  L ++ E+ E P+++  +  +   + ++++D+   + +       LK +    SK+   S +S +  +P  +S+ +  +       +++ +    ME S +E     + K   +  E  S +  L   M    S +      +++++ +   Y +T  TTN+HP LSSLVNY  PVKF GF++       FHMSSFSE+  LG++K  A E VNYNK Q SRIYP+G RVDSSNFLPQIFWNAGCQMV+LNFQ+ D+ MQLN G+FEYN  SGY+LKP+F+RR +R FDPFSESP+DGVIAA C V++ISGQFLS++KIGTYVEV+MYGLPTDTIRKE +T+V+P NGLNP+Y ED  FVFRKV+LP+LAVLR  V++E GK +GQR+LPLDGLQ G+RHISLRS+ N    LS  LF +I + TYVPD  +  VDAL+DPRA +S ++ + + +A+MG + S+I D+ P+T ++  +  K+   +  S+ D   +N + G  +   T+ + S+     +R+ N    P     FK D I  E+  + L   K   K LKR  KE  +L+K+  K+ + + K
Sbjct:    2 AKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLR-EGKLDEEDELNETPEVVGEDSVSPREMPAKENDEAHPELKQNFIAKNLKGFGF--SKKQPDSSTSLLTASPTPSSSSMAMSNANNPFSSSTLNSPQPMERSRSEKRSFRQKKGGVFGDELHSDSAALIDFMRTASSRKKKPVLTKEEEERIFAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDP-FVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDV-PNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASST----IRSPNEQPQPVAVDKFKVDPI--EV--DDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQK 1051

HSP 2 Score: 56.6102 bits (135), Expect = 1.896e-7
Identity = 30/80 (37.50%), Postives = 49/80 (61.25%), Query Frame = 2

Query: 3671 KVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            K++S+ Q  Q   L+L  + E K++   QTK SME  +++  D   + KAERDRR++EL + N K F+++R+   MK  +
Sbjct: 1195 KLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQK 1274

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Celegans
Match: egl-8 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Source:UniProtKB/Swiss-Prot;Acc:G5EBH0])

HSP 1 Score: 922.539 bits (2383), Expect = 0.000e+0
Identity = 495/1100 (45.00%), Postives = 699/1100 (63.55%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQS-NIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTA-----------------------------DVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQ-EPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKK--YLHEKKSSAKDLTSLMVGDESAE-----IEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSS-LFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQST-DGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKL 3460
            +K ++F W+  I  EL  G++FD YDDE   LE+N  V++DE GFFL W  E  +A V DM  I + ++G   KD +++ +L+ +  S  I +RT+ I+   D VN+ +   + +  ++       +  +  + +  ++CP TQL K+   L + VN   KIP+KL+ KTF+SG+ EK+V + L +L L  +K                               ++D    TFEKF  L N ICPRT++Q+LF  LS  K+YLT +R+I FLNE QRDPRLNEIL+P+ +   +  +L  +E +   +  G++S D F R+LMSDEN PVFLDR+++  DMDQPL HYYINSSHNTYLTGRQ+ GKSS ++YRQVLL+GCRC+ELDCWDG G+++ EPIITHGKAMC+D+ F+DV+  IRD AF  S +PV LSFENHCSK  Q K+AKYC ++ G+ LL+KP E   L+ GV LPSP +L+ KILIKNKRL  + E+ QLD FL+ +  L ++ E+ E P+++  +  +   + ++++D+   + +       LK +    SK+   S +S +  +P  +S+ +  +       +++ +    ME S +E     + K   +  E  S +  L   M    S +      +++++ +   Y +T  TTN+HP LSSLVNY  PVKF GF++       FHMSSFSE+  LG++K  A E VNYNK Q SRIYP+G RVDSSNFLPQIFWNAGCQMV+LNFQ+ D+ MQLN G+FEYN  SGY+LKP+F+RR +R FDPFSESP+DGVIAA C V++ISGQFLS++KIGTYVEV+MYGLPTDTIRKE +T+V+P NGLNP+Y ED  FVFRKV+LP+LAVLR  V++E GK +GQR+LPLDGLQ G+RHISLRS+ N    LS  LF +I + TYVPD  +  VDAL+DPRA +S ++ + + +A+MG + S+I D+ P+T ++  +  K+   +  S+ D   +N + G  +   T+ + S+     +R+ N    P     FK D I  E+  + L   K   K LKR  KE  +L+K+  K+ + + K    + +KL
Sbjct:    2 AKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLR-EGKLDEEDELNETPEVVGEDSVSPREMPAKENDEAHPELKQNFIAKNLKGFGF--SKKQPDSSTSLLTASPTPSSSSMAMSNANNPFSSSTLNSPQPMERSRSEKRSFRQKKGGVFGDELHSDSAALIDFMRTASSRKKKPVLTKEEEERIFAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDP-FVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDV-PNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASST----IRSPNEQPQPVAVDKFKVDPI--EV--DDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQKQQQTNVDKL 1088

HSP 2 Score: 56.6102 bits (135), Expect = 2.104e-7
Identity = 30/80 (37.50%), Postives = 49/80 (61.25%), Query Frame = 2

Query: 3671 KVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            K++S+ Q  Q   L+L  + E K++   QTK SME  +++  D   + KAERDRR++EL + N K F+++R+   MK  +
Sbjct: 1211 KLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQK 1290

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Celegans
Match: egl-8 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Source:UniProtKB/Swiss-Prot;Acc:G5EBH0])

HSP 1 Score: 919.072 bits (2374), Expect = 0.000e+0
Identity = 493/1091 (45.19%), Postives = 695/1091 (63.70%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQS-NIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTA-----------------------------DVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQ-EPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKK--YLHEKKSSAKDLTSLMVGDESAE-----IEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSS-LFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQST-DGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLK 3433
            +K ++F W+  I  EL  G++FD YDDE   LE+N  V++DE GFFL W  E  +A V DM  I + ++G   KD +++ +L+ +  S  I +RT+ I+   D VN+ +   + +  ++       +  +  + +  ++CP TQL K+   L + VN   KIP+KL+ KTF+SG+ EK+V + L +L L  +K                               ++D    TFEKF  L N ICPRT++Q+LF  LS  K+YLT +R+I FLNE QRDPRLNEIL+P+ +   +  +L  +E +   +  G++S D F R+LMSDEN PVFLDR+++  DMDQPL HYYINSSHNTYLTGRQ+ GKSS ++YRQVLL+GCRC+ELDCWDG G+++ EPIITHGKAMC+D+ F+DV+  IRD AF  S +PV LSFENHCSK  Q K+AKYC ++ G+ LL+KP E   L+ GV LPSP +L+ KILIKNKRL  + E+ QLD FL+ +  L ++ E+ E P+++  +  +   + ++++D+   + +       LK +    SK+   S +S +  +P  +S+ +  +       +++ +    ME S +E     + K   +  E  S +  L   M    S +      +++++ +   Y +T  TTN+HP LSSLVNY  PVKF GF++       FHMSSFSE+  LG++K  A E VNYNK Q SRIYP+G RVDSSNFLPQIFWNAGCQMV+LNFQ+ D+ MQLN G+FEYN  SGY+LKP+F+RR +R FDPFSESP+DGVIAA C V++ISGQFLS++KIGTYVEV+MYGLPTDTIRKE +T+V+P NGLNP+Y ED  FVFRKV+LP+LAVLR  V++E GK +GQR+LPLDGLQ G+RHISLRS+ N    LS  LF +I + TYVPD  +  VDAL+DPRA +S ++ + + +A+MG + S+I D+ P+T ++  +  K+   +  S+ D   +N + G  +   T+ + S+     +R+ N    P     FK D I  E+  + L   K   K LKR  KE  +L+K+  K+ + + K
Sbjct:    2 AKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLR-EGKLDEEDELNETPEVVGEDSVSPREMPAKENDEAHPELKQNFIAKNLKGFGF--SKKQPDSSTSLLTASPTPSSSSMAMSNANNPFSSSTLNSPQPMERSRSEKRSFRQKKGGVFGDELHSDSAALIDFMRTASSRKKKPVLTKEEEERIFAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDP-FVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDV-PNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASST----IRSPNEQPQPVAVDKFKVDPI--EV--DDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQK 1079

HSP 2 Score: 56.6102 bits (135), Expect = 2.038e-7
Identity = 30/80 (37.50%), Postives = 49/80 (61.25%), Query Frame = 2

Query: 3671 KVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            K++S+ Q  Q   L+L  + E K++   QTK SME  +++  D   + KAERDRR++EL + N K F+++R+   MK  +
Sbjct: 1223 KLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQK 1302

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Celegans
Match: egl-8 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 [Source:UniProtKB/Swiss-Prot;Acc:G5EBH0])

HSP 1 Score: 479.559 bits (1233), Expect = 6.142e-152
Identity = 244/528 (46.21%), Postives = 341/528 (64.58%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQS-NIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEK-----------------------------TADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQ-EPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGED 1771
            +K ++F W+  I  EL  G++FD YDDE   LE+N  V++DE GFFL W  E  +A V DM  I + ++G   KD +++ +L+ +  S  I +RT+ I+   D VN+ +   + +  ++       +  +  + +  ++CP TQL K+   L + VN   KIP+KL+ KTF+SG+ EK+V + L +L L  +K                               ++D    TFEKF  L N ICPRT++Q+LF  LS  K+YLT +R+I FLNE QRDPRLNEIL+P+ +   +  +L  +E +   +  G++S D F R+LMSDEN PVFLDR+++  DMDQPL HYYINSSHNTYLTGRQ+ GKSS ++YRQVLL+GCRC+ELDCWDG G+++ EPIITHGKAMC+D+ F+DV+  IRD AF  S +PV LSFENHCSK  Q K+AKYC ++ G+ LL+KP E   L+ GV LPSP +L+ KILIKNKRL  + E+ QLD FL+ +  L ++ E+ E P+++ GED
Sbjct:    2 AKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLR-EGKLDEEDELNETPEVV-GED 527

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Fly
Match: norpA (gene:FBgn0262738 transcript:FBtr0343599)

HSP 1 Score: 533.487 bits (1373), Expect = 1.823e-165
Identity = 259/494 (52.43%), Postives = 354/494 (71.66%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFD-FYDDEL----NILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNI---EDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLE 1735
            +K YEF W   +P EL  G +FD ++++E     N  E + L KVDE+GFFL WKSE  +  V ++  +SD+++G   KD K+L ++  K  +NI   + R+L I  N+D++N+     I  D+     W+  +R + HN+KA NICPM  L+KHW+RL   V  + KIP+K +AKTFASG+ EKLV+  +K+  LP +K A +   QFTF+KFY L + +CPR DI++LF S+++GK D+++ ++ I+F+N+ QRDPR+NEILYP         I++ YEL+  +K   ++S+D F RYLMSDENAPVFLDRLD + +MDQPLAHYYINSSHNTYL+GRQ  GKSSV+MYRQ LLAGCRCVELDCW+GKG+D+EPI+THG A C++ILF+D I AI DCAFV+S YPV LSFENHC++ QQYK+AKYC++  G+ LL +P+  H L+ G+PLP P KLK KILIKNKR+  E EK++L+++LKG+     D E
Sbjct:    2 TKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPE 495

HSP 2 Score: 467.618 bits (1202), Expect = 2.005e-141
Identity = 245/585 (41.88%), Postives = 352/585 (60.17%), Query Frame = 2

Query: 2156 HTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            ++  TTNVHP+LSS+VNYAQP+KF GF+   EK    +MSSF+E+A + ++K  +I+ VNYNK Q+SRIYP+G R DSSN++PQ+FWNAGCQMV+LNFQSSDL MQLNQG+FEYN   GY+LKP+FMRR+++ FDPF+++P+DGVIAA C VK+I+GQFLS+KK+GTYVEVDM+GLP+DT++KEFRTR+V  NGLNP+Y ED  FVFRKV+LPDLAVLR GV+EE+GK++GQR+LPLDGLQ G+RH+SLR+E NFP +L  LF  I L  YVPDGF  F+  LSDPR      + + + M  +G E                                         Q     +      + + +   LV+ P   +  + +  F+++  + + E  T+    K+  KE +++QK Q   I++L+K    S + + +    + SI  + K    M I  +++   +ML    ++ Q+  K                          ++  +Q  Q K L     R++K+++ +Q K S +  + V  D   + K E+DRRLRE    N KRF+++++   +K  R
Sbjct:  539 YSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDP-FVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIE----------------------------------------EQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTL---RKKHAKERTSVQKTQNAAIDKLIKGK--SKDDIRNDANIKNSINDQTKQWTDM-IARHRKEEWDMLRQHVQDSQDAMKA-------------------------LMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGR 1051

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Fly
Match: norpA (gene:FBgn0262738 transcript:FBtr0100670)

HSP 1 Score: 533.487 bits (1373), Expect = 1.823e-165
Identity = 259/494 (52.43%), Postives = 354/494 (71.66%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFD-FYDDEL----NILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNI---EDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLE 1735
            +K YEF W   +P EL  G +FD ++++E     N  E + L KVDE+GFFL WKSE  +  V ++  +SD+++G   KD K+L ++  K  +NI   + R+L I  N+D++N+     I  D+     W+  +R + HN+KA NICPM  L+KHW+RL   V  + KIP+K +AKTFASG+ EKLV+  +K+  LP +K A +   QFTF+KFY L + +CPR DI++LF S+++GK D+++ ++ I+F+N+ QRDPR+NEILYP         I++ YEL+  +K   ++S+D F RYLMSDENAPVFLDRLD + +MDQPLAHYYINSSHNTYL+GRQ  GKSSV+MYRQ LLAGCRCVELDCW+GKG+D+EPI+THG A C++ILF+D I AI DCAFV+S YPV LSFENHC++ QQYK+AKYC++  G+ LL +P+  H L+ G+PLP P KLK KILIKNKR+  E EK++L+++LKG+     D E
Sbjct:    2 TKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPE 495

HSP 2 Score: 467.618 bits (1202), Expect = 2.005e-141
Identity = 245/585 (41.88%), Postives = 352/585 (60.17%), Query Frame = 2

Query: 2156 HTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            ++  TTNVHP+LSS+VNYAQP+KF GF+   EK    +MSSF+E+A + ++K  +I+ VNYNK Q+SRIYP+G R DSSN++PQ+FWNAGCQMV+LNFQSSDL MQLNQG+FEYN   GY+LKP+FMRR+++ FDPF+++P+DGVIAA C VK+I+GQFLS+KK+GTYVEVDM+GLP+DT++KEFRTR+V  NGLNP+Y ED  FVFRKV+LPDLAVLR GV+EE+GK++GQR+LPLDGLQ G+RH+SLR+E NFP +L  LF  I L  YVPDGF  F+  LSDPR      + + + M  +G E                                         Q     +      + + +   LV+ P   +  + +  F+++  + + E  T+    K+  KE +++QK Q   I++L+K    S + + +    + SI  + K    M I  +++   +ML    ++ Q+  K                          ++  +Q  Q K L     R++K+++ +Q K S +  + V  D   + K E+DRRLRE    N KRF+++++   +K  R
Sbjct:  539 YSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDP-FVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIE----------------------------------------EQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTL---RKKHAKERTSVQKTQNAAIDKLIKGK--SKDDIRNDANIKNSINDQTKQWTDM-IARHRKEEWDMLRQHVQDSQDAMKA-------------------------LMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGR 1051

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Fly
Match: norpA (gene:FBgn0262738 transcript:FBtr0100671)

HSP 1 Score: 533.487 bits (1373), Expect = 1.823e-165
Identity = 259/494 (52.43%), Postives = 354/494 (71.66%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFD-FYDDEL----NILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNI---EDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLE 1735
            +K YEF W   +P EL  G +FD ++++E     N  E + L KVDE+GFFL WKSE  +  V ++  +SD+++G   KD K+L ++  K  +NI   + R+L I  N+D++N+     I  D+     W+  +R + HN+KA NICPM  L+KHW+RL   V  + KIP+K +AKTFASG+ EKLV+  +K+  LP +K A +   QFTF+KFY L + +CPR DI++LF S+++GK D+++ ++ I+F+N+ QRDPR+NEILYP         I++ YEL+  +K   ++S+D F RYLMSDENAPVFLDRLD + +MDQPLAHYYINSSHNTYL+GRQ  GKSSV+MYRQ LLAGCRCVELDCW+GKG+D+EPI+THG A C++ILF+D I AI DCAFV+S YPV LSFENHC++ QQYK+AKYC++  G+ LL +P+  H L+ G+PLP P KLK KILIKNKR+  E EK++L+++LKG+     D E
Sbjct:    2 TKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKIWLDGIRKITHNVKANNICPMMCLRKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPE 495

HSP 2 Score: 467.618 bits (1202), Expect = 2.005e-141
Identity = 245/585 (41.88%), Postives = 352/585 (60.17%), Query Frame = 2

Query: 2156 HTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            ++  TTNVHP+LSS+VNYAQP+KF GF+   EK    +MSSF+E+A + ++K  +I+ VNYNK Q+SRIYP+G R DSSN++PQ+FWNAGCQMV+LNFQSSDL MQLNQG+FEYN   GY+LKP+FMRR+++ FDPF+++P+DGVIAA C VK+I+GQFLS+KK+GTYVEVDM+GLP+DT++KEFRTR+V  NGLNP+Y ED  FVFRKV+LPDLAVLR GV+EE+GK++GQR+LPLDGLQ G+RH+SLR+E NFP +L  LF  I L  YVPDGF  F+  LSDPR      + + + M  +G E                                         Q     +      + + +   LV+ P   +  + +  F+++  + + E  T+    K+  KE +++QK Q   I++L+K    S + + +    + SI  + K    M I  +++   +ML    ++ Q+  K                          ++  +Q  Q K L     R++K+++ +Q K S +  + V  D   + K E+DRRLRE    N KRF+++++   +K  R
Sbjct:  539 YSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDP-FVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIE----------------------------------------EQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTL---RKKHAKERTSVQKTQNAAIDKLIKGK--SKDDIRNDANIKNSINDQTKQWTDM-IARHRKEEWDMLRQHVQDSQDAMKA-------------------------LMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGR 1051

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Fly
Match: norpA (gene:FBgn0262738 transcript:FBtr0070651)

HSP 1 Score: 525.013 bits (1351), Expect = 2.116e-162
Identity = 257/494 (52.02%), Postives = 351/494 (71.05%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFD-FYDDEL----NILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNI---EDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLE 1735
            +K YEF W   +P EL  G +FD ++++E     N  E + L KVDE+GFFL WKSE  +  V ++  +SD+++G   KD K+L ++  K  +NI   + R+L I  N+D++N+     I  D+     W  +LR + HN +A N+CP   L KHW+RL   V  + KIP+K +AKTFASG+ EKLV+  +K+  LP +K A +   QFTF+KFY L + +CPR DI++LF S+++GK D+++ ++ I+F+N+ QRDPR+NEILYP         I++ YEL+  +K   ++S+D F RYLMSDENAPVFLDRLD + +MDQPLAHYYINSSHNTYL+GRQ  GKSSV+MYRQ LLAGCRCVELDCW+GKG+D+EPI+THG A C++ILF+D I AI DCAFV+S YPV LSFENHC++ QQYK+AKYC++  G+ LL +P+  H L+ G+PLP P KLK KILIKNKR+  E EK++L+++LKG+     D E
Sbjct:    2 TKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKSWQKNLRLITHNNRATNVCPRVNLMKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPE 495

HSP 2 Score: 467.233 bits (1201), Expect = 2.377e-141
Identity = 245/585 (41.88%), Postives = 352/585 (60.17%), Query Frame = 2

Query: 2156 HTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            ++  TTNVHP+LSS+VNYAQP+KF GF+   EK    +MSSF+E+A + ++K  +I+ VNYNK Q+SRIYP+G R DSSN++PQ+FWNAGCQMV+LNFQSSDL MQLNQG+FEYN   GY+LKP+FMRR+++ FDPF+++P+DGVIAA C VK+I+GQFLS+KK+GTYVEVDM+GLP+DT++KEFRTR+V  NGLNP+Y ED  FVFRKV+LPDLAVLR GV+EE+GK++GQR+LPLDGLQ G+RH+SLR+E NFP +L  LF  I L  YVPDGF  F+  LSDPR      + + + M  +G E                                         Q     +      + + +   LV+ P   +  + +  F+++  + + E  T+    K+  KE +++QK Q   I++L+K    S + + +    + SI  + K    M I  +++   +ML    ++ Q+  K                          ++  +Q  Q K L     R++K+++ +Q K S +  + V  D   + K E+DRRLRE    N KRF+++++   +K  R
Sbjct:  539 YSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDP-FVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIE----------------------------------------EQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTL---RKKHAKERTSVQKTQNAAIDKLIKGK--SKDDIRNDANIKNSINDQTKQWTDM-IARHRKEEWDMLRQHVQDSQDAMKA-------------------------LMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGR 1051

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Fly
Match: norpA (gene:FBgn0262738 transcript:FBtr0301475)

HSP 1 Score: 525.013 bits (1351), Expect = 2.116e-162
Identity = 257/494 (52.02%), Postives = 351/494 (71.05%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFD-FYDDEL----NILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNI---EDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLE 1735
            +K YEF W   +P EL  G +FD ++++E     N  E + L KVDE+GFFL WKSE  +  V ++  +SD+++G   KD K+L ++  K  +NI   + R+L I  N+D++N+     I  D+     W  +LR + HN +A N+CP   L KHW+RL   V  + KIP+K +AKTFASG+ EKLV+  +K+  LP +K A +   QFTF+KFY L + +CPR DI++LF S+++GK D+++ ++ I+F+N+ QRDPR+NEILYP         I++ YEL+  +K   ++S+D F RYLMSDENAPVFLDRLD + +MDQPLAHYYINSSHNTYL+GRQ  GKSSV+MYRQ LLAGCRCVELDCW+GKG+D+EPI+THG A C++ILF+D I AI DCAFV+S YPV LSFENHC++ QQYK+AKYC++  G+ LL +P+  H L+ G+PLP P KLK KILIKNKR+  E EK++L+++LKG+     D E
Sbjct:    2 TKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKSWQKNLRLITHNNRATNVCPRVNLMKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPE 495

HSP 2 Score: 467.233 bits (1201), Expect = 2.377e-141
Identity = 245/585 (41.88%), Postives = 352/585 (60.17%), Query Frame = 2

Query: 2156 HTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            ++  TTNVHP+LSS+VNYAQP+KF GF+   EK    +MSSF+E+A + ++K  +I+ VNYNK Q+SRIYP+G R DSSN++PQ+FWNAGCQMV+LNFQSSDL MQLNQG+FEYN   GY+LKP+FMRR+++ FDPF+++P+DGVIAA C VK+I+GQFLS+KK+GTYVEVDM+GLP+DT++KEFRTR+V  NGLNP+Y ED  FVFRKV+LPDLAVLR GV+EE+GK++GQR+LPLDGLQ G+RH+SLR+E NFP +L  LF  I L  YVPDGF  F+  LSDPR      + + + M  +G E                                         Q     +      + + +   LV+ P   +  + +  F+++  + + E  T+    K+  KE +++QK Q   I++L+K    S + + +    + SI  + K    M I  +++   +ML    ++ Q+  K                          ++  +Q  Q K L     R++K+++ +Q K S +  + V  D   + K E+DRRLRE    N KRF+++++   +K  R
Sbjct:  539 YSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDP-FVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIE----------------------------------------EQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTL---RKKHAKERTSVQKTQNAAIDKLIKGK--SKDDIRNDANIKNSINDQTKQWTDM-IARHRKEEWDMLRQHVQDSQDAMKA-------------------------LMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGR 1051

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Zebrafish
Match: PLCB4 (phospholipase C beta 4 [Source:NCBI gene;Acc:100537538])

HSP 1 Score: 530.406 bits (1365), Expect = 1.049e-163
Identity = 249/450 (55.33%), Postives = 321/450 (71.33%), Query Frame = 2

Query:  371 ILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKH--QLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLK 1705
            + E NC  KVDE GFFL+WKSE  E  V +  LI+ ++    +KD KVL  L+   K +SN+EDR + I   +D VNL  +  + ++      W   LRS+  N +A N+CPMT L+KHW+RL  L NVN +IP++ + +TFASG+ EK +FQ+LK+L LP  K  ++    FTF+KFY+L   ICPRTDI+ LF      K DYL+ ++ + FLN+ QRDPRLNEIL+P+ N      I+  YE        G +S D F R+LMSDENAPVFLDRL+++Q+MD PL+HY+INSSHNTYLTGRQF GKSSV++YRQVLL GCRCVELDCWDGKG+DQEPIITHGKAMC+D+LF+DVI  I++ AF+TS YPV LSFENHC+K QQYK+A+YCE++ G+ LL +P+E    ++E G PLPSP  LK KILIKN+RL  E EK QL+ F K
Sbjct:    5 VFESNCFFKVDESGFFLTWKSEGKEGQVLEFSLINSIRDASALKDPKVLCALEASGKCESNLEDRIICICSGTDLVNLSFMYMVTQNPTTAKEWTDGLRSLIQNTRANNVCPMTCLRKHWMRLSFLTNVNGQIPVRSITRTFASGKTEKGIFQALKDLGLPSGKNDEIQREIFTFDKFYSLTQKICPRTDIEVLFKKFKGDKGDYLSVEQFVHFLNDNQRDPRLNEILFPFFNSKCAFQIIQRYEPVKALVCAGLLSCDGFCRFLMSDENAPVFLDRLEVYQEMDHPLSHYFINSSHNTYLTGRQFGGKSSVEIYRQVLLTGCRCVELDCWDGKGEDQEPIITHGKAMCTDVLFKDVIQGIKETAFLTSEYPVILSFENHCTKHQQYKLARYCEDIFGDLLLKQPLEDFPPKMEPGCPLPSPNDLKGKILIKNRRLKPEVEKKQLEDFRK 454

HSP 2 Score: 517.309 bits (1331), Expect = 7.937e-159
Identity = 290/624 (46.47%), Postives = 399/624 (63.94%), Query Frame = 2

Query: 2108 SAEIE--KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFE-EITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHK-------------------KKTENQMKID-MNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            SAE E   D+  V  +Y + + TTN+HPYLS+++NYAQ VKF GF+   EK    +MSSF+E+  LG+++ +AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LNFQ+ DLAMQLNQG+FEYN + G++LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y  ++ FVFRKVILPDLAVLR+ V+++  KLIGQR+LPLDGLQ+G+RHISLR+E N P  L+++FC I L TYVPDGF + VDALSDP+  +S  E +   M  MG E S+I D+       NKK+   +           + M     ++S   +            EN+  S  +  +  D ++   ++T + L +TKT +K +K+Q KE + L+K+  K    L  SHS   ++  +   K+K  + K                   +  E QMK   MN +S  ++L + +    E +++   H   EQ +   +  Q  E   K+L   Q  Q   L L+ +R+ KEM   Q K+SME+++ +  D + +NKAER+RR+REL   N ++FL +R+   MK  +
Sbjct:  523 SAEEENVADELAVIQSYTYVAATTNIHPYLSNIINYAQAVKFTGFDEAEEKNIHHNMSSFNESVGLGYLRTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGSCGFLLKPDFMRRPDRMFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNAEA-FVFRKVILPDLAVLRVAVYDDNNKLIGQRILPLDGLQSGYRHISLRNEYNKPLPLATVFCNIILKTYVPDGFGAIVDALSDPKKFLSICEKRTDQMRAMGIEASDIADVPSDVWKGNKKRKTNQ-----------AGMMMKPQKDSDRPR------------ENMPISSKEVCEPADSSVLTPQLTIDDLKQTKTFLKLIKKQQKEVNALKKKHAKAHAALRSSHSAQLDRTVAQHEKEKHTLEKQLHKNTSRKVSESSSLEMSRDIEQQMKTAVMNHKS--KVLRIIDVYASECSEMLRWHSAEEQTVVEQHLLQQCEQLHKLLMLEQEQQTHQLTLLHERQSKEMRTNQAKTSMESSKAISQDKSIKNKAERERRVRELNSTNTRKFLTERKRLAMKQTK 1120

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Zebrafish
Match: plcb3 (phospholipase C, beta 3 (phosphatidylinositol-specific) [Source:ZFIN;Acc:ZDB-GENE-030616-594])

HSP 1 Score: 350.132 bits (897), Expect = 3.880e-99
Identity = 221/579 (38.17%), Postives = 326/579 (56.30%), Query Frame = 2

Query: 2171 TNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHIS----REEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAK---RFLDQRR 3886
             N    +S+LVNY +PVKF  F +  +++  F MSSF ET  +  +KN   E V YNK Q+SRIYP+G RVDSSN++PQ+FWN GCQMVALNFQ+ DLAMQLN G FEYN   GY+LKPEFMRR+++ FDPF+   +DG++A T +VKIISGQFL++KK+G YVEVDM+GLP DT RK +RT+    N L+P++ +D  FVF KV+LP LA LR+ V+EE GK IG R+LP+  L+ G+ +I L++E N P  L SL     +  Y+P+    + +AL++P  H+S    RE   L LM +                      T+    +++  DGTDS+    +        + S+     V   +L   P+  K+   + + + I PES++E K    YLK        L K+Q KE  EL K H    +K+ +   +QK++ +++ +E Q K    ++ I+   SL +   ++      N L+ E   ++   ++     L VL Q QL   K        EVK+ H +      EAN+  + D     +A + ++L+++CD   K   + LD++R
Sbjct:  564 VNATEEMSTLVNYIEPVKFKSFEVAAKRKKFFEMSSFVETKGMDTLKNSPTEFVEYNKKQMSRIYPKGTRVDSSNYMPQLFWNVGCQMVALNFQTLDLAMQLNMGVFEYNGRCGYLLKPEFMRRTDKHFDPFTTDIVDGIVANTVKVKIISGQFLNDKKVGVYVEVDMFGLPADTKRK-YRTKTSNNNSLDPVW-DDETFVFNKVVLPTLASLRVAVYEENGKFIGHRILPVSALRPGYHYICLKNELNQPLMLPSLLVYTEVQDYIPNEHQEYAEALTNPIKHLSLLAQRESQLLALMED---------------------PTEGGPTKQEEGDGTDSSC---VTSADPIFPLPSSPTLPSVPT-DLNPPPSGQKEDLVNNVLKVIEPESVDELKQHNSYLK--------LLKKQCKEFKELSKKH---LKKMLALSKEQKTLFNQQSSELQRKRSQIEKRIR--TSLKKNGSEDSVHRELNELDLELQKQMEQFREEHMQKLLVLRQGQLQMEK--------EVKQFHLK------EANQ-KLKDIAIECQAAQIKKLKDVCDKEKKELQKMLDRKR 1087

HSP 2 Score: 348.206 bits (892), Expect = 1.581e-98
Identity = 193/457 (42.23%), Postives = 276/457 (60.39%), Query Frame = 2

Query:  311 NIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKS-EAYVYDMPLISDVKSGV---KIKDEKVLSQL-QDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHC-SKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKR 1660
            ++ E LK+G+ F  +D+E N       ++VD  GFFL W    S EA + DM  I D ++G      KD+++   L   K   N + R L +   +D VN+  L F          W   L  +  N+ + N    T L K + +L L V  + KIP+K + K F+   ++K V  +L+   L   +   + P  FT+E F N LN + PR +++ +F  L S+GK +L+ D+++ F+N  QRD RLNE+LYP   R+ V+ +++ YE N  +  + +IS+  F +YL  +EN  V  +RLD+  DM+QPL+HY+INSSHNTYLT  Q  G SSV+MYRQVLL GCRC+ELDCW G+  ++EPIITHG  M ++I F+DVI AI + AF TSPYP+ LSFENH  S  QQ K+A+YC  + G+ LL  P++K+ L  G  LPSP++L  KILIKNK+
Sbjct:   17 SVNEVLKRGSKFIKWDEEANSTPSLITLRVDPNGFFLYWTGGTSMEAEILDMSHIRDTRTGKFAKTPKDQRIREMLFSGKADGNSDSRLLTVVYGNDLVNISFLNFQAVQDGYCKLWTDELFKLATNMLSQNASRNTFLLKAYTKLKLQVTQDGKIPVKNILKMFS---DKKRVEMALEHCGLIFNRVDGIKPDDFTWEMFQNFLNKLSPRPEVERIFVDLGSKGKPFLSLDQLMDFINRKQRDSRLNEVLYPPLKRDQVRQLMEKYETNTSQLERDQISLMSFTKYLGGEENTVVPPERLDIIDDMNQPLSHYFINSSHNTYLTVGQLTGLSSVEMYRQVLLTGCRCIELDCWKGRPPEEEPIITHGFTMTTEIPFKDVIEAIAESAFKTSPYPLILSFENHVDSAKQQAKMAEYCRSMFGDALLIDPLDKYPLVPGQQLPSPQELLGKILIKNKK 470

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Zebrafish
Match: plcb3 (phospholipase C, beta 3 (phosphatidylinositol-specific) [Source:ZFIN;Acc:ZDB-GENE-030616-594])

HSP 1 Score: 350.132 bits (897), Expect = 3.937e-99
Identity = 221/579 (38.17%), Postives = 326/579 (56.30%), Query Frame = 2

Query: 2171 TNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHIS----REEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAK---RFLDQRR 3886
             N    +S+LVNY +PVKF  F +  +++  F MSSF ET  +  +KN   E V YNK Q+SRIYP+G RVDSSN++PQ+FWN GCQMVALNFQ+ DLAMQLN G FEYN   GY+LKPEFMRR+++ FDPF+   +DG++A T +VKIISGQFL++KK+G YVEVDM+GLP DT RK +RT+    N L+P++ +D  FVF KV+LP LA LR+ V+EE GK IG R+LP+  L+ G+ +I L++E N P  L SL     +  Y+P+    + +AL++P  H+S    RE   L LM +                      T+    +++  DGTDS+    +        + S+     V   +L   P+  K+   + + + I PES++E K    YLK        L K+Q KE  EL K H    +K+ +   +QK++ +++ +E Q K    ++ I+   SL +   ++      N L+ E   ++   ++     L VL Q QL   K        EVK+ H +      EAN+  + D     +A + ++L+++CD   K   + LD++R
Sbjct:  564 VNATEEMSTLVNYIEPVKFKSFEVAAKRKKFFEMSSFVETKGMDTLKNSPTEFVEYNKKQMSRIYPKGTRVDSSNYMPQLFWNVGCQMVALNFQTLDLAMQLNMGVFEYNGRCGYLLKPEFMRRTDKHFDPFTTDIVDGIVANTVKVKIISGQFLNDKKVGVYVEVDMFGLPADTKRK-YRTKTSNNNSLDPVW-DDETFVFNKVVLPTLASLRVAVYEENGKFIGHRILPVSALRPGYHYICLKNELNQPLMLPSLLVYTEVQDYIPNEHQEYAEALTNPIKHLSLLAQRESQLLALMED---------------------PTEGGPTKQEEGDGTDSSC---VTSADPIFPLPSSPTLPSVPT-DLNPPPSGQKEDLVNNVLKVIEPESVDELKQHNSYLK--------LLKKQCKEFKELSKKH---LKKMLALSKEQKTLFNQQSSELQRKRSQIEKRIR--TSLKKNGSEDSVHRELNELDLELQKQMEQFREEHMQKLLVLRQGQLQMEK--------EVKQFHLK------EANQ-KLKDIAIECQAAQIKKLKDVCDKEKKELQKMLDRKR 1087

HSP 2 Score: 348.206 bits (892), Expect = 1.810e-98
Identity = 193/457 (42.23%), Postives = 276/457 (60.39%), Query Frame = 2

Query:  311 NIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKS-EAYVYDMPLISDVKSGV---KIKDEKVLSQL-QDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHC-SKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKR 1660
            ++ E LK+G+ F  +D+E N       ++VD  GFFL W    S EA + DM  I D ++G      KD+++   L   K   N + R L +   +D VN+  L F          W   L  +  N+ + N    T L K + +L L V  + KIP+K + K F+   ++K V  +L+   L   +   + P  FT+E F N LN + PR +++ +F  L S+GK +L+ D+++ F+N  QRD RLNE+LYP   R+ V+ +++ YE N  +  + +IS+  F +YL  +EN  V  +RLD+  DM+QPL+HY+INSSHNTYLT  Q  G SSV+MYRQVLL GCRC+ELDCW G+  ++EPIITHG  M ++I F+DVI AI + AF TSPYP+ LSFENH  S  QQ K+A+YC  + G+ LL  P++K+ L  G  LPSP++L  KILIKNK+
Sbjct:   17 SVNEVLKRGSKFIKWDEEANSTPSLITLRVDPNGFFLYWTGGTSMEAEILDMSHIRDTRTGKFAKTPKDQRIREMLFSGKADGNSDSRLLTVVYGNDLVNISFLNFQAVQDGYCKLWTDELFKLATNMLSQNASRNTFLLKAYTKLKLQVTQDGKIPVKNILKMFS---DKKRVEMALEHCGLIFNRVDGIKPDDFTWEMFQNFLNKLSPRPEVERIFVDLGSKGKPFLSLDQLMDFINRKQRDSRLNEVLYPPLKRDQVRQLMEKYETNTSQLERDQISLMSFTKYLGGEENTVVPPERLDIIDDMNQPLSHYFINSSHNTYLTVGQLTGLSSVEMYRQVLLTGCRCIELDCWKGRPPEEEPIITHGFTMTTEIPFKDVIEAIAESAFKTSPYPLILSFENHVDSAKQQAKMAEYCRSMFGDALLIDPLDKYPLVPGQQLPSPQELLGKILIKNKK 470

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Zebrafish
Match: plch1 (phospholipase C, eta 1 [Source:ZFIN;Acc:ZDB-GENE-060503-398])

HSP 1 Score: 320.472 bits (820), Expect = 4.606e-91
Identity = 251/750 (33.47%), Postives = 370/750 (49.33%), Query Frame = 2

Query:  803 NEKLVFQSLKELN--LPCEKT------ADVDPSQ--FTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYL-LTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDG-ALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQ-ETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSG-----TTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKK----------IGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEE--TGK-LIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITL 2959
            N + ++Q L ++N  LP  K       AD D  Q   TFE+F     M+  R D+  L    S+ KD+LT + +  FL   Q+   +               I++ +E++   K  G + ++ F  Y+ S           +++QDMDQP+ +Y+I SSHNTYLTG Q    S  DMY  VL AGCRCVE+DCWDG   D EP++ HG  + S I F+ VI  I   AFV + +PV LS ENHCS  QQ KIA++ +E+ G+ L + + + K   +    LPSP  LK KIL+K KRLP          +L       ++ E+++D      ED   L   +S        ++    +++ L      G K+   SFS        I + +   + G+ +    NS   + K +S +  S +  KHK++    KS  K         +S E E D Q      +   G     T  +   LS LV +   V         E   C ++ SFSE  A   + + A   + +N+ QLSRIYP   R+DSSNF PQ +WN GCQ+VALN+Q+    MQLN+ +F  N  SGY+LKP  M  S+ AF+P S+ P+         +KIISGQ L +            I  +VEV++ GLP D  +++  TRVV  NG NP++ E  +F      +P++A++R  V++    G+  +GQR +    L  G+RH+ L  EG      +S+F  IT+
Sbjct:  123 NMEEIYQLLHKMNVNLPRRKVKQMFQEADTDDQQGTLTFEEFTVFYKMMSLRRDLFLLLMCFSDKKDHLTAEELGNFLRVEQKMSSVTP--------ECCLDIINKFEVSEENKQNGVLGIEGFTNYMRSPACDVFNPQHHEINQDMDQPICNYFIASSHNTYLTGDQLLSHSKTDMYAWVLQAGCRCVEVDCWDGP--DGEPMVQHGYTLTSKITFKSVIETINKYAFVNNEFPVILSIENHCSIQQQKKIAQHLKEIFGDKLDVGEALNKDPKQ----LPSPNLLKGKILLKGKRLPS---------YLSADA---EEGEVSDDDSADEIEDDFKLKNSTSNGPSQHQVESHIRKKLDSLMKESQIGDKEDTDSFS--------IRALLRATHEGLQRNLRKNSKDGMKKSQSRSFISNL--KHKRH---SKSRLKC--------QSVETEDDSQQEPSGGQFNRGGRRRKTIKLSRDLSDLVVFTNSVA--SQECLDEGSPC-NVLSFSEARAQNLVHHRAERFLTFNQRQLSRIYPSAYRIDSSNFNPQTYWNVGCQLVALNYQTEGRMMQLNRAKFMVNGGSGYVLKPSLM--SKGAFNPLSDEPLPANPKKQLVIKIISGQQLPKPPDSMLGDRGEIIDPFVEVEIIGLPVDCCKEQ--TRVVDDNGFNPVWEETLSFTLH---MPEVALVRFLVWDHDPIGRDFVGQRTIAFSSLMPGYRHVYL--EG---MTEASIFVHITV 810

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Zebrafish
Match: CABZ01072157.1 (pep chromosome:GRCz11:17:2348540:2386569:-1 gene:ENSDARG00000090381.3 transcript:ENSDART00000121614.3 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CABZ01072157.1)

HSP 1 Score: 306.99 bits (785), Expect = 5.880e-89
Identity = 153/300 (51.00%), Postives = 205/300 (68.33%), Query Frame = 2

Query: 2120 EKDDQTVGMNYRHTSGT-TNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVP-ANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDP 3013
            E+D++ +  +   T+G     +  +S+LVNY QP KF+ F    +K  CF +SSF ET     +  +A++ V YNK QLSRIYP+G RVDSSN+ PQ FW+AGCQ VALN+Q+ D  MQLN   FE+N  +GY+LK + MRRS++ FDPF +  +D +IA+T  +KI SGQFLS+K + T VEV++ GLP D  RK +RT++   ANG+NP + E+  F+F KV+LP++A LR+ V EE GK IG R++PLD LQTGF+HI LRSE N P  L SLF  I +  YVP  FA F DAL +P
Sbjct:  124 EQDEEKMKNSDEGTAGQEVTAYEEMSALVNYVQPNKFISFENAAKKNRCFVISSFVETKGESLIAKNAVDWVEYNKRQLSRIYPKGTRVDSSNYSPQPFWSAGCQFVALNYQTMDFPMQLNMALFEFNGRTGYLLKHDVMRRSDKKFDPFCDR-IDTIIASTLTIKIYSGQFLSDKAVKTGVEVELIGLPKDPKRK-YRTKMSSTANGINPDWNEEP-FIFEKVLLPEMAYLRLVVQEEGGKFIGHRIIPLDALQTGFQHIGLRSESNMPLMLPSLFVHIEMKDYVPAAFADFSDALFNP 420

HSP 2 Score: 51.9878 bits (123), Expect = 7.043e-6
Identity = 24/49 (48.98%), Postives = 34/49 (69.39%), Query Frame = 2

Query: 1514 QQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKR 1660
            QQ K+A YC  + G+ LL   ++K+ L+ G P+PSP +L  KILIKNK+
Sbjct:   12 QQEKMANYCRTIFGDALLIDLLDKYPLKPGQPIPSPSELMGKILIKNKK 60

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Xenopus
Match: ppp1r16b (protein phosphatase 1 regulatory subunit 16B [Source:Xenbase;Acc:XB-GENE-982398])

HSP 1 Score: 596.275 bits (1536), Expect = 0.000e+0
Identity = 275/485 (56.70%), Postives = 359/485 (74.02%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLD----MFLKGQT 1714
            +K+YEF W++ +P  ++ GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++ G   KD K+LS L+   K +  ++ + L +   +D VN+     + + +++   WV  L+S+ HN +A N+ PMT LKKHW++L  L N++ KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++PS FTF+KFY L   ICPRTD ++LF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++TYE +   K  G+IS   F RYLMSDENAPVFLDRL+L+Q+M+ PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI+D AFVTS YPV LSFENHCSK QQYK++KYCEE+ G+ LL+K +E H L+ G PLPSP  LK KILIKNKRL  E EK QL+    M   G+T
Sbjct:    2 AKVYEFNWQKAVPSFMQDGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRYGAVPKDPKILSALEAVGKAEQELDGKILCVCCGTDLVNISFTYMVAESAELAKQWVEGLKSITHNFRANNVSPMTCLKKHWMKLTFLTNISGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPSAFTFDKFYELTQKICPRTDTEELFKKINGDKSDYLTVDQLVSFLNEHQRDPRLNEILFPFFDAKRAMQIIETYEPDEELKKAGQISSHGFCRYLMSDENAPVFLDRLELYQEMEHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKDTAFVTSEYPVILSFENHCSKYQQYKMSKYCEEIFGDLLLSKALESHPLDTGRPLPSPNDLKRKILIKNKRLKAEVEKKQLEALKSMMEAGET 486

HSP 2 Score: 533.487 bits (1373), Expect = 2.226e-164
Identity = 290/634 (45.74%), Postives = 405/634 (63.88%), Query Frame = 2

Query: 2039 HKKYLHEKKSSAKDLT---SLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLK-------SHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            H ++    + S+ DL+   +  +  + A   +D+Q    +Y++   TTN+HP+LSS++NYAQPVKF GF +  E+   F+MSSF+E+  LG++K  A+E VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y  D  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ P+ ++ N K+ K    +   T  + S ++      S T    +     K ++  LV +P                 +   + K I    K+  KE S +QK Q  ++++++        SH  + EK     G       KK+TEN++++ +      ++  +  ++ +E  ++       EQ L+ ++  Q  E   ++L  +   Q + L+L   RE KEM   Q K SME  + +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  511 HPEFKFGSELSSDDLSQKEAANIAKKGAITVEDEQAWMASYKYVGATTNIHPFLSSMINYAQPVKFQGFKVAEERNIHFNMSSFNESVGLGYLKTHALEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVY-NDEPFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PADNTKNDKKGKTSNAKTNVTPQSSSEVR-----PSVTAAPGAGTENKKGKSSRLVSAP-------------AFLKQQKKQQKEIAALKKKHLKEHSVVQKLQCTQVDKIVAQFDKEKVSHERTLEKSIKKKGASNCHEMKKETENKIQV-LTSDHKSKVKDIVAQHTKEFTEMVKAQNAEEQTLRDVHLSQQCELLKELLRGIHAQQMQQLKLTHDRESKEMKANQAKLSMENCKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1123

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Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLD----MFLKGQT 1714
            +K+YEF W++ +P  ++ GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++ G   KD K+LS L+   K +  ++ + L +   +D VN+     + + +++   WV  L+S+ HN +A N+ PMT LKKHW++L  L N++ KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++PS FTF+KFY L   ICPRTD ++LF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++TYE +   K  G+IS   F RYLMSDENAPVFLDRL+L+Q+M+ PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI+D AFVTS YPV LSFENHCSK QQYK++KYCEE+ G+ LL+K +E H L+ G PLPSP  LK KILIKNKRL  E EK QL+    M   G+T
Sbjct:    2 AKVYEFNWQKAVPSFMQDGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRYGAVPKDPKILSALEAVGKAEQELDGKILCVCCGTDLVNISFTYMVAESAELAKQWVEGLKSITHNFRANNVSPMTCLKKHWMKLTFLTNISGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPSAFTFDKFYELTQKICPRTDTEELFKKINGDKSDYLTVDQLVSFLNEHQRDPRLNEILFPFFDAKRAMQIIETYEPDEELKKAGQISSHGFCRYLMSDENAPVFLDRLELYQEMEHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKDTAFVTSEYPVILSFENHCSKYQQYKMSKYCEEIFGDLLLSKALESHPLDTGRPLPSPNDLKRKILIKNKRLKAEVEKKQLEALKSMMEAGET 486

HSP 2 Score: 532.717 bits (1371), Expect = 7.669e-164
Identity = 285/603 (47.26%), Postives = 392/603 (65.01%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLK-------SHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HP+LSS++NYAQPVKF GF +  E+   F+MSSF+E+  LG++K  A+E VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y  D  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ P+ ++ N K+ K    +   T  + S ++      S T    +     K ++  LV +P                 +   + K I    K+  KE S +QK Q  ++++++        SH  + EK     G       KK+TEN++++ +      ++  +  ++ +E  ++       EQ L+ ++  Q  E   ++L  +   Q + L+L   RE KEM   Q K SME  + +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  555 EDEQAWMASYKYVGATTNIHPFLSSMINYAQPVKFQGFKVAEERNIHFNMSSFNESVGLGYLKTHALEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVY-NDEPFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PADNTKNDKKGKTSNAKTNVTPQSSSEVR-----PSVTAAPGAGTENKKGKSSRLVSAP-------------AFLKQQKKQQKEIAALKKKHLKEHSVVQKLQCTQVDKIVAQFDKEKVSHERTLEKSIKKKGASNCHEMKKETENKIQV-LTSDHKSKVKDIVAQHTKEFTEMVKAQNAEEQTLRDVHLSQQCELLKELLRGIHAQQMQQLKLTHDRESKEMKANQAKLSMENCKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1136

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Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLD----MFLKGQT 1714
            +K+YEF W++ +P  ++ GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++ G   KD K+LS L+   K +  ++ + L +   +D VN+     + + +++   WV  L+S+ HN +A N+ PMT LKKHW++L  L N++ KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++PS FTF+KFY L   ICPRTD ++LF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++TYE +   K  G+IS   F RYLMSDENAPVFLDRL+L+Q+M+ PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI+D AFVTS YPV LSFENHCSK QQYK++KYCEE+ G+ LL+K +E H L+ G PLPSP  LK KILIKNKRL  E EK QL+    M   G+T
Sbjct:    2 AKVYEFNWQKAVPSFMQDGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRYGAVPKDPKILSALEAVGKAEQELDGKILCVCCGTDLVNISFTYMVAESAELAKQWVEGLKSITHNFRANNVSPMTCLKKHWMKLTFLTNISGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPSAFTFDKFYELTQKICPRTDTEELFKKINGDKSDYLTVDQLVSFLNEHQRDPRLNEILFPFFDAKRAMQIIETYEPDEELKKAGQISSHGFCRYLMSDENAPVFLDRLELYQEMEHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKDTAFVTSEYPVILSFENHCSKYQQYKMSKYCEEIFGDLLLSKALESHPLDTGRPLPSPNDLKRKILIKNKRLKAEVEKKQLEALKSMMEAGET 486

HSP 2 Score: 535.028 bits (1377), Expect = 1.505e-164
Identity = 286/614 (46.58%), Postives = 394/614 (64.17%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKI-------DMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQ-----------LQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HP+LSS++NYAQPVKF GF +  E+   F+MSSF+E+  LG++K  A+E VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y  D  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ P+ ++ N K+            G  SN K  +  +SS+          +VR  ++  +P    + K      ++  E L + K  +K  K+Q KE + L+K+ +KE + + K      +K+ +   K+K + H++  E  +K        +M + +  ++  LT  ++ +   +   H      +      + +      LSQ           +   Q + L+L   RE KEM   Q K SME  + +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  555 EDEQAWMASYKYVGATTNIHPFLSSMINYAQPVKFQGFKVAEERNIHFNMSSFNESVGLGYLKTHALEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVY-NDEPFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PADNTKNDKK------------GKTSNAKTNVTPQSSS----------EVR-PSVTAAPGAGTENKKAIDIPQVKVEELKQMKAFLKQQKKQQKEIAALKKKHLKEHSVVQKLQCTQVDKIVAQFDKEK-VSHERTLEKSIKKKGASNCHEMKKETENKIQVLTSDHKSKVKDIVAQHTKEFTEMVKAQNAEEQTLRDVHLSQQCELLKELLRGIHAQQMQQLKLTHDRESKEMKANQAKLSMENCKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1142

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Xenopus
Match: ppp1r16b (protein phosphatase 1 regulatory subunit 16B [Source:Xenbase;Acc:XB-GENE-982398])

HSP 1 Score: 595.89 bits (1535), Expect = 0.000e+0
Identity = 275/485 (56.70%), Postives = 359/485 (74.02%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLD----MFLKGQT 1714
            +K+YEF W++ +P  ++ GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++ G   KD K+LS L+   K +  ++ + L +   +D VN+     + + +++   WV  L+S+ HN +A N+ PMT LKKHW++L  L N++ KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++PS FTF+KFY L   ICPRTD ++LF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++TYE +   K  G+IS   F RYLMSDENAPVFLDRL+L+Q+M+ PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI+D AFVTS YPV LSFENHCSK QQYK++KYCEE+ G+ LL+K +E H L+ G PLPSP  LK KILIKNKRL  E EK QL+    M   G+T
Sbjct:    2 AKVYEFNWQKAVPSFMQDGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRYGAVPKDPKILSALEAVGKAEQELDGKILCVCCGTDLVNISFTYMVAESAELAKQWVEGLKSITHNFRANNVSPMTCLKKHWMKLTFLTNISGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPSAFTFDKFYELTQKICPRTDTEELFKKINGDKSDYLTVDQLVSFLNEHQRDPRLNEILFPFFDAKRAMQIIETYEPDEELKKAGQISSHGFCRYLMSDENAPVFLDRLELYQEMEHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKDTAFVTSEYPVILSFENHCSKYQQYKMSKYCEEIFGDLLLSKALESHPLDTGRPLPSPNDLKRKILIKNKRLKAEVEKKQLEALKSMMEAGET 486

HSP 2 Score: 533.102 bits (1372), Expect = 4.054e-164
Identity = 290/634 (45.74%), Postives = 405/634 (63.88%), Query Frame = 2

Query: 2039 HKKYLHEKKSSAKDLT---SLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLK-------SHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            H ++    + S+ DL+   +  +  + A   +D+Q    +Y++   TTN+HP+LSS++NYAQPVKF GF +  E+   F+MSSF+E+  LG++K  A+E VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y  D  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ P+ ++ N K+ K    +   T  + S ++      S T    +     K ++  LV +P                 +   + K I    K+  KE S +QK Q  ++++++        SH  + EK     G       KK+TEN++++ +      ++  +  ++ +E  ++       EQ L+ ++  Q  E   ++L  +   Q + L+L   RE KEM   Q K SME  + +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  511 HPEFKFGSELSSDDLSQKEAANIAKKGAITVEDEQAWMASYKYVGATTNIHPFLSSMINYAQPVKFQGFKVAEERNIHFNMSSFNESVGLGYLKTHALEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVY-NDEPFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PADNTKNDKKGKTSNAKTNVTPQSSSEVR-----PSVTAAPGAGTENKKGKSSRLVSAP-------------AFLKQQKKQQKEIAALKKKHLKEHSVVQKLQCTQVDKIVAQFDKEKVSHERTLEKSIKKKGASNCHEMKKETENKIQV-LTSDHKSKVKDIVAQHTKEFTEMVKAQNAEEQTLRDVHLSQQCELLKELLRGIHAQQMQQLKLTHDRESKEMKANQAKLSMENCKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1123

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Xenopus
Match: ppp1r16b (protein phosphatase 1 regulatory subunit 16B [Source:Xenbase;Acc:XB-GENE-982398])

HSP 1 Score: 595.504 bits (1534), Expect = 0.000e+0
Identity = 275/485 (56.70%), Postives = 359/485 (74.02%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLD----MFLKGQT 1714
            +K+YEF W++ +P  ++ GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++ G   KD K+LS L+   K +  ++ + L +   +D VN+     + + +++   WV  L+S+ HN +A N+ PMT LKKHW++L  L N++ KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++PS FTF+KFY L   ICPRTD ++LF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++TYE +   K  G+IS   F RYLMSDENAPVFLDRL+L+Q+M+ PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI+D AFVTS YPV LSFENHCSK QQYK++KYCEE+ G+ LL+K +E H L+ G PLPSP  LK KILIKNKRL  E EK QL+    M   G+T
Sbjct:    2 AKVYEFNWQKAVPSFMQDGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRYGAVPKDPKILSALEAVGKAEQELDGKILCVCCGTDLVNISFTYMVAESAELAKQWVEGLKSITHNFRANNVSPMTCLKKHWMKLTFLTNISGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPSAFTFDKFYELTQKICPRTDTEELFKKINGDKSDYLTVDQLVSFLNEHQRDPRLNEILFPFFDAKRAMQIIETYEPDEELKKAGQISSHGFCRYLMSDENAPVFLDRLELYQEMEHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKDTAFVTSEYPVILSFENHCSKYQQYKMSKYCEEIFGDLLLSKALESHPLDTGRPLPSPNDLKRKILIKNKRLKAEVEKKQLEALKSMMEAGET 486

HSP 2 Score: 523.472 bits (1347), Expect = 5.509e-161
Identity = 278/596 (46.64%), Postives = 378/596 (63.42%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HP+LSS++NYAQPVKF GF +  E+   F+MSSF+E+  LG++K  A+E VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y  D  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ P+ ++ N K+            G  SN K  +  +SS+          +VR  ++  +P    + K      ++  E L + K  +K  K+Q KE + L+K+ +K + +++  H+    ++          +  +  E Q   D++     E+L                                     ++L  +   Q + L+L   RE KEM   Q K SME  + +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  555 EDEQAWMASYKYVGATTNIHPFLSSMINYAQPVKFQGFKVAEERNIHFNMSSFNESVGLGYLKTHALEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVY-NDEPFVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PADNTKNDKK------------GKTSNAKTNVTPQSSS----------EVR-PSVTAAPGAGTENKKAIDIPQVKVEELKQMKAFLKQQKKQQKEIAALKKKHLK-VKDIVAQHTKEFTEM----------VKAQNAEEQTLRDVHLSQQCELLK------------------------------------ELLRGIHAQQMQQLKLTHDRESKEMKANQAKLSMENCKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1078

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Mouse
Match: Plcb4 (phospholipase C, beta 4 [Source:MGI Symbol;Acc:MGI:107464])

HSP 1 Score: 595.89 bits (1535), Expect = 0.000e+0
Identity = 274/476 (57.56%), Postives = 355/476 (74.58%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++     KD K+L+ L+   K+++++E R L +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  L N   KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ FT+EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G PLPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRQAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTTGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 553.518 bits (1425), Expect = 6.857e-172
Identity = 294/614 (47.88%), Postives = 407/614 (66.29%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRSIQEMLSLT-----------EKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S                   +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK       +++ + +  ++ +LT            ++ +E +++   H   EQ ++ L+  Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANPAKANVTPQSSSELR-----PTTTAALGSG-----------------QEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMKKKGGSNCLEIKKETEIKIQTLTTDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1131

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Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++     KD K+L+ L+   K+++++E R L +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  L N   KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ FT+EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G PLPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRQAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTTGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 553.518 bits (1425), Expect = 6.857e-172
Identity = 294/614 (47.88%), Postives = 407/614 (66.29%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRSIQEMLSLT-----------EKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S                   +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK       +++ + +  ++ +LT            ++ +E +++   H   EQ ++ L+  Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANPAKANVTPQSSSELR-----PTTTAALGSG-----------------QEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMKKKGGSNCLEIKKETEIKIQTLTTDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1131

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Mouse
Match: Plcb4 (phospholipase C, beta 4 [Source:MGI Symbol;Acc:MGI:107464])

HSP 1 Score: 592.808 bits (1527), Expect = 0.000e+0
Identity = 274/476 (57.56%), Postives = 355/476 (74.58%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++     KD K+L+ L+   K+++++E R L +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  L N   KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ FT+EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G PLPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRQAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTTGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 509.99 bits (1312), Expect = 1.879e-157
Identity = 252/467 (53.96%), Postives = 332/467 (71.09%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK 3523
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S                   +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK
Sbjct:  543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANPAKANVTPQSSSELR-----PTTTAALGSG-----------------QEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMK 984

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Mouse
Match: Plcb4 (phospholipase C, beta 4 [Source:MGI Symbol;Acc:MGI:107464])

HSP 1 Score: 589.341 bits (1518), Expect = 0.000e+0
Identity = 274/474 (57.81%), Postives = 355/474 (74.89%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLD 1693
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++     KD K+L+ L+   K+++++E R L +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  L N   KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ FT+EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G PLPSP  LK KILIKNKRL  E EK QL+
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRQAAIPKDPKILAALEAVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTTGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLE 475

HSP 2 Score: 481.871 bits (1239), Expect = 9.386e-149
Identity = 219/329 (66.57%), Postives = 271/329 (82.37%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTS 3109
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+   TS
Sbjct:  555 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADVPSDTS 882

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Mouse
Match: Plcb1 (phospholipase C, beta 1 [Source:MGI Symbol;Acc:MGI:97613])

HSP 1 Score: 373.629 bits (958), Expect = 1.638e-107
Identity = 189/420 (45.00%), Postives = 260/420 (61.90%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAI--FEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHS 3442
            +S+LVNY QPVKF  F I  ++   F MSSF ET  L  +    +E V YNK QLSRIYP+G RVDSSN++PQ+FWNAGCQMVALNFQ+ DLAMQ+N G +EYN  SGY LKPEFMRR ++ FDPF+E  +DG++A T  VKIISGQFLS+KK+GTYVEVDM+GLP DT RK F+T+    N +NP++ E+   VF+KV+LP LA LRI  +EE GK IG R+LP+  ++ G+ +I LR+E N P  L ++F  I +  YVPD +A  ++ALS+P  +++  E + K +A +  E  E          + K+    E      ++   +  + G+N  +S      +           V +P K++D     +   E  T E L + K+ VK  K+  KE  +L KR  K+  EL+K H+
Sbjct:  540 MSNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVW-EEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEE---------EVKKEADPGETSSEAPSETRTTPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHT 949

HSP 2 Score: 372.859 bits (956), Expect = 3.237e-107
Identity = 190/450 (42.22%), Postives = 277/450 (61.56%), Query Frame = 2

Query:  314 IPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIK---DEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKP-QQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILI 1648
            + + LKKG  F  +DD+  I+    +++ D  GFF  W  +  E  + D+ L+ D + G   K   D K+   L      ++E R + +    D VN+  L  +    ++   W   + S+  N+ A N+     L+K + +L L V    +IPLK + + F++ R  K V  +L+  +LP  +   +    FT + +   LN +CPR +I ++F+   ++ K YLT D+M+ F+N  QRDPRLNEILYP   +  VQ +++ YE N     +G++SVD F RYL  +EN  V  ++LDL++DM QPL+HY+INSSHNTYLT  Q  G SSV+MYRQVLL+GCRCVELDCW G+  ++EP+ITHG  M ++I F++VI AI +CAF TSP+P+ LSFENH   P QQ K+A+YC  + G+ LL +P+EK+ LE+GVPLPSP  L YKIL+
Sbjct:   18 VSDSLKKGTKFVKWDDDSTIV-TPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADR--KRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILV 464

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q15147|PLCB4_HUMAN (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 OS=Homo sapiens OX=9606 GN=PLCB4 PE=1 SV=3)

HSP 1 Score: 594.734 bits (1532), Expect = 0.000e+0
Identity = 272/476 (57.14%), Postives = 357/476 (75.00%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+W+SE  E  V +  LI+ ++SG   KD K+L+ L+   K+++++E R + +   +D VN+     + ++ ++   WV  LRS+ HN +A N+ PMT LKKHW++L  + N N KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ F++EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G  LPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVLECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 558.14 bits (1437), Expect = 1.026e-172
Identity = 297/614 (48.37%), Postives = 408/614 (66.45%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRS---IQEMLS--------LTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S V                 +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK       ++M + +   IQ + S        +  ++ +E +++   H   EQ ++ L+  Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANTAKANVTPQSSSELR-----PTTTAALASGV-----------------EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1131

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q9QW07|PLCB4_RAT (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 OS=Rattus norvegicus OX=10116 GN=Plcb4 PE=1 SV=2)

HSP 1 Score: 590.497 bits (1521), Expect = 0.000e+0
Identity = 273/476 (57.35%), Postives = 355/476 (74.58%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQD--KTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++ +P  L++GA+FD Y++E  + E NCL KVDEFGFFL+WKSE  E  V +  LI+ ++     KD K+L+ L+   K+++++E R L +   +D VN+     + ++ +I   WV  LRS+ HN +A N+ PMT LKKHW++L  L N + KIP++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ FT+EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQY+++KYCE++ G+ LL + +E H LE G  LPSP  LK KILIKNKRL  E EK QL+  
Sbjct:    2 AKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVLECSLINSIRLAAIPKDPKILAALESVGKSENDLEGRILCVCSGTDLVNIGFTYMVAENPEITKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFLTNTSGKIPVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEELKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYQMSKYCEDLFGDLLLKQALESHPLEPGRLLPSPNDLKRKILIKNKRLKPEVEKKQLEAL 477

HSP 2 Score: 553.132 bits (1424), Expect = 8.088e-171
Identity = 294/614 (47.88%), Postives = 407/614 (66.29%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRS---IQEMLS--------LTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   +  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + S                   +  K   +  ++  E L + K  +K+LK+Q KE ++L+K+  KE + + K H    +K+ +   K+KS  H+K  E  MK       +++ + +   IQ + S        +  ++ +E +++   H   EQ ++ L+  Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  543 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQLRAMGIETSDIADV-PSDTSKNDKKGKANPAKANVTPQSSSELR-----PTTTAALGSG-----------------QEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEKST-HEKILEKAMKKKGGSNCLEIKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSEMINTHSAEEQEIRDLHLSQQCELLRKLLINAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 1131

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. UniProt/SwissProt
Match: sp|Q07722|PLCB4_BOVIN (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (Fragment) OS=Bos taurus OX=9913 GN=PLCB4 PE=1 SV=1)

HSP 1 Score: 556.214 bits (1432), Expect = 1.011e-173
Identity = 294/614 (47.88%), Postives = 406/614 (66.12%), Query Frame = 2

Query: 2123 KDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMK-------IDMNQRS---IQEMLS--------LTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +D+Q    +Y++   TTN+HPYLS+++NYAQPVKF GF++  E+   ++MSSF+E+  LG++K  AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWN+GCQMV+LN+Q+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+S FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF   VDALSDP+  +S  E +   M  MG ETS+I D+ PS +S N K+ K    +   T  + S ++      ++T  + + +                 +  K   +  ++  E L + K  +K+LK+Q KE S+L+K+  KE + + K H    +K+ +   K+K + H+K  E  MK       ++M + +   IQ + S        +  ++ +E + +   H   EQ ++ L   Q  E   K+L      Q + L+L   RE KEM   Q K SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MK ++
Sbjct:  391 EDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNSGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEES-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKKFLSITEKRADQMRAMGIETSDIADV-PSDTSKNDKKGKANTAKANVTPQSSSELR-----PTTTAALGAGL-----------------EAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELSSLKKKHAKEHSTMQKLHCTQVDKIVAQYDKEK-LTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQHTKEWSDMINTHSAEEQEIRDLLLSQQCELLRKLLISAHEQQTQQLKLSHDRESKEMRAHQAKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSK 979

HSP 2 Score: 440.654 bits (1132), Expect = 1.834e-131
Identity = 203/313 (64.86%), Postives = 248/313 (79.23%), Query Frame = 2

Query:  764 PLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            P++ + +TFASG+ EK++FQ+LKEL LP  K  +++P+ FT+EKFY L   ICPRTDI+DLF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K QG IS D F RYLMSDENAPVFLDRL+L+Q+MD PLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLLAGCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSK QQYK++KYCE++ G+ LL + +E H LE G PLPSP  LK KILIK +    E EK QL+  
Sbjct:    1 PVRSITRTFASGKTEKVIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKQGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKKQTTETEVEKKQLEAL 313

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. UniProt/SwissProt
Match: sp|P13217|PIPA_DROME (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Drosophila melanogaster OX=7227 GN=norpA PE=1 SV=4)

HSP 1 Score: 525.013 bits (1351), Expect = 2.121e-161
Identity = 257/494 (52.02%), Postives = 351/494 (71.05%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFD-FYDDEL----NILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNI---EDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLE 1735
            +K YEF W   +P EL  G +FD ++++E     N  E + L KVDE+GFFL WKSE  +  V ++  +SD+++G   KD K+L ++  K  +NI   + R+L I  N+D++N+     I  D+     W  +LR + HN +A N+CP   L KHW+RL   V  + KIP+K +AKTFASG+ EKLV+  +K+  LP +K A +   QFTF+KFY L + +CPR DI++LF S+++GK D+++ ++ I+F+N+ QRDPR+NEILYP         I++ YEL+  +K   ++S+D F RYLMSDENAPVFLDRLD + +MDQPLAHYYINSSHNTYL+GRQ  GKSSV+MYRQ LLAGCRCVELDCW+GKG+D+EPI+THG A C++ILF+D I AI DCAFV+S YPV LSFENHC++ QQYK+AKYC++  G+ LL +P+  H L+ G+PLP P KLK KILIKNKR+  E EK++L+++LKG+     D E
Sbjct:    2 TKKYEFDWIIPVPPELTTGCVFDRWFENEKETKENDFERDALFKVDEYGFFLYWKSEGRDGDVIELCQVSDIRAGGTPKDPKILDKVTKKNGTNIPELDKRSLTICSNTDYINITYHHVICPDAATAKSWQKNLRLITHNNRATNVCPRVNLMKHWMRLSYCVEKSGKIPVKTLAKTFASGKTEKLVYTCIKDAGLPDDKNATMTKEQFTFDKFYALYHKVCPRNDIEELFTSITKGKQDFISLEQFIQFMNDKQRDPRMNEILYPLYEEKRCTEIINDYELDEEKKKNVQMSLDGFKRYLMSDENAPVFLDRLDFYMEMDQPLAHYYINSSHNTYLSGRQIGGKSSVEMYRQTLLAGCRCVELDCWNGKGEDEEPIVTHGHAYCTEILFKDCIQAIADCAFVSSEYPVILSFENHCNRAQQYKLAKYCDDFFGDLLLKEPLPDHPLDPGLPLPPPCKLKRKILIKNKRMKPEVEKVELELWLKGELKTDDDPE 495

HSP 2 Score: 467.233 bits (1201), Expect = 2.383e-140
Identity = 245/585 (41.88%), Postives = 352/585 (60.17%), Query Frame = 2

Query: 2156 HTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            ++  TTNVHP+LSS+VNYAQP+KF GF+   EK    +MSSF+E+A + ++K  +I+ VNYNK Q+SRIYP+G R DSSN++PQ+FWNAGCQMV+LNFQSSDL MQLNQG+FEYN   GY+LKP+FMRR+++ FDPF+++P+DGVIAA C VK+I+GQFLS+KK+GTYVEVDM+GLP+DT++KEFRTR+V  NGLNP+Y ED  FVFRKV+LPDLAVLR GV+EE+GK++GQR+LPLDGLQ G+RH+SLR+E NFP +L  LF  I L  YVPDGF  F+  LSDPR      + + + M  +G E                                         Q     +      + + +   LV+ P   +  + +  F+++  + + E  T+    K+  KE +++QK Q   I++L+K    S + + +    + SI  + K    M I  +++   +ML    ++ Q+  K                          ++  +Q  Q K L     R++K+++ +Q K S +  + V  D   + K E+DRRLRE    N KRF+++++   +K  R
Sbjct:  539 YSGSTTNVHPWLSSMVNYAQPIKFQGFDKAIEKNIAHNMSSFAESAGMNYLKQSSIDFVNYNKRQMSRIYPKGTRADSSNYMPQVFWNAGCQMVSLNFQSSDLPMQLNQGKFEYNGGCGYLLKPDFMRRADKDFDPFADAPVDGVIAAQCSVKVIAGQFLSDKKVGTYVEVDMFGLPSDTVKKEFRTRLVANNGLNPVYNEDP-FVFRKVVLPDLAVLRFGVYEESGKILGQRILPLDGLQAGYRHVSLRTEANFPMSLPMLFVNIELKIYVPDGFEDFMAMLSDPRGFAGAAKQQNEQMKALGIE----------------------------------------EQSGGAARDAGKAKEEEKKEPPLVFEPVTLESLRQEKGFQKVGKKQIKELDTL---RKKHAKERTSVQKTQNAAIDKLIKGK--SKDDIRNDANIKNSINDQTKQWTDM-IARHRKEEWDMLRQHVQDSQDAMKA-------------------------LMLTVQAAQIKQLEDRHARDIKDLNAKQAKMSADTAKEVQNDKTLKTKNEKDRRLREKRQNNVKRFMEEKKQIGVKQGR 1051

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. UniProt/SwissProt
Match: sp|G5EBH0|PLCB_CAEEL (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8 OS=Caenorhabditis elegans OX=6239 GN=egl-8 PE=1 SV=1)

HSP 1 Score: 486.878 bits (1252), Expect = 2.266e-144
Identity = 244/528 (46.21%), Postives = 341/528 (64.58%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQS-NIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTA-----------------------------DVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQ-EPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGED 1771
            +K ++F W+  I  EL  G++FD YDDE   LE+N  V++DE GFFL W  E  +A V DM  I + ++G   KD +++ +L+ +  S  I +RT+ I+   D VN+ +   + +  ++       +  +  + +  ++CP TQL K+   L + VN   KIP+KL+ KTF+SG+ EK+V + L +L L  +K                               ++D    TFEKF  L N ICPRT++Q+LF  LS  K+YLT +R+I FLNE QRDPRLNEIL+P+ +   +  +L  +E +   +  G++S D F R+LMSDEN PVFLDR+++  DMDQPL HYYINSSHNTYLTGRQ+ GKSS ++YRQVLL+GCRC+ELDCWDG G+++ EPIITHGKAMC+D+ F+DV+  IRD AF  S +PV LSFENHCSK  Q K+AKYC ++ G+ LL+KP E   L+ GV LPSP +L+ KILIKNKRL  + E+ QLD FL+ +  L ++ E+ E P+++ GED
Sbjct:    2 AKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKYTPARVINRSMGKKFRNFYKCSRGRKRKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLR-EGKLDEEDELNETPEVV-GED 527

HSP 2 Score: 461.455 bits (1186), Expect = 2.506e-135
Identity = 233/440 (52.95%), Postives = 310/440 (70.45%), Query Frame = 2

Query: 2120 EKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSS-LFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQST-DGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLK 3433
            +++++ +   Y +T  TTN+HP LSSLVNY  PVKF GF++       FHMSSFSE+  LG++K  A E VNYNK Q SRIYP+G RVDSSNFLPQIFWNAGCQMV+LNFQ+ D+ MQLN G+FEYN  SGY+LKP+F+RR +R FDPFSESP+DGVIAA C V++ISGQFLS++KIGTYVEV+MYGLPTDTIRKE +T+V+P NGLNP+Y ED  FVFRKV+LP+LAVLR  V++E GK +GQR+LPLDGLQ G+RHISLRS+ N    LS  LF +I + TYVPD  +  VDAL+DPRA +S ++ + + +A+MG + S+I D+ P+T ++  +  K+   +  S+ D   +N + G  +   T+ + S+     +R+ N    P     FK D I  E+  + L   K   K LKR  KE  +L+K+  K+ + + K
Sbjct:  735 KEEEERIFAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDP-FVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDV-PNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASST----IRSPNEQPQPVAVDKFKVDPI--EV--DDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQK 1164

HSP 3 Score: 56.9954 bits (136), Expect = 2.107e-6
Identity = 30/80 (37.50%), Postives = 49/80 (61.25%), Query Frame = 2

Query: 3671 KVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            K++S+ Q  Q   L+L  + E K++   QTK SME  +++  D   + KAERDRR++EL + N K F+++R+   MK  +
Sbjct: 1308 KLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQK 1387

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. TrEMBL
Match: A0A4Z2CYF8 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Schistosoma japonicum OX=6182 GN=EWB00_006501 PE=4 SV=1)

HSP 1 Score: 1308.51 bits (3385), Expect = 0.000e+0
Identity = 656/1227 (53.46%), Postives = 855/1227 (69.68%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDL-EIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGM-NYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKK-KTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            MTSDIAKRQRTVPS+K +EF W+R +PE L+ G  FD YD+E  ILE NC V+VD+ GFF+ W+SE +++   ++  ISDV+SG K KDEK+ +Q+Q+++  +  DR + I    D VN++    + KD +  +FW+ SLRS+ HN KAAN+CPMTQL+KHWLRL L VN  N+IP++++ KTFASGRNE++V+QSLK+LNLP  K  D+DP++F FEKFY L + ICPRTDI+DLF SLS+GK+++  D+MI FLNETQRDPRLNEILYP++N+ +++YI + YE     K+  EIS++CFYRYLMSD+NA VFLD+LD++QDMDQPL+HYYINSSHNTYL GRQF GKSSV++YRQVLLAGCRC+ELDCWDG+G+DQEPIITHGKAMCSDILF+DVIYAIRD AFV S  PV +SFENHCSK QQYK+AKYCEE+LG+ LLTKP++ + LE GVPLP PEKLK KILIKNKRL  E EK QL++FLKGQTD  Q+  E+ EDPDL    D                                             VP     N ++    IG    +T               S   +   + L    SSA +L  L +  E   +  +++ + M +Y +T  T+++HP LSS +NYAQPVKF GF++  ++    HMSSFSET ALG +KN AIE VNYNK Q+SRIYPRGNRVDSSN++PQIFWNAGCQMVALNFQ+ DLAMQLNQG+FEYN N GY+LKPEFMRR ER FDPFSESPMDGVIAATCEVKIISGQFLS++K+GTYVEVDMYGLPTDTIRKEFRTRVVP NGLNP+Y +D+ FVFRKV+LPDLAVLR  V+E+TGKLIGQRVLPLDGLQ G+RHISLR+EGNFP +L +LFC+++L+TYVP+G    VDALSDPRA +S+EE ++K +A+MG ++SEI D+ PST   N K+    +    ++     +    ++       ++SN  +   + ++  + P      + D I++              K +K+Q KE   LQKRQ K+   +L++H++ T+KL +   K++S   +    EN     +      +M  L  ++  + + L    +    +L L      K+  +K++ ++Q  Q++ LR++Q REVKEM  QQTK+S+E++R V+ D   RNKAERDRR+REL DYN KRF+DQR+ Q  +H++
Sbjct:    1 MTSDIAKRQRTVPSAKAFEFIWKRPVPEVLQSGEHFDRYDEEAGILEPNCFVRVDKDGFFIYWQSENNDSQQLELSQISDVRSGTKPKDEKLTAQIQERSGKSW-DRIVTICSGLDLVNINYTHMVAKDVETASFWIQSLRSLTHNTKAANVCPMTQLRKHWLRLTLTVNARNRIPVRVIMKTFASGRNERIVYQSLKDLNLPHGKNDDIDPNEFPFEKFYELYHKICPRTDIEDLFKSLSKGKNHIHADKMIEFLNETQRDPRLNEILYPFANKQTIKYIQENYETQEEFKNTDEISIECFYRYLMSDDNACVFLDKLDIYQDMDQPLSHYYINSSHNTYLIGRQFGGKSSVEIYRQVLLAGCRCIELDCWDGRGEDQEPIITHGKAMCSDILFKDVIYAIRDTAFVASDCPVIMSFENHCSKQQQYKLAKYCEEILGDMLLTKPLDNYPLEPGVPLPPPEKLKRKILIKNKRLKPEAEKQQLELFLKGQTDAIQEENEVTEDPDLTIDRDDG-----------------------------------------DGVPGNKPNNGDLSSTTIGGGGSDTTI-------------SLSTIPTPQTLSTCTSSA-ELKRLQLKKEEGNLTAEEEQIMMAHYHYTGATSSIHPLLSSFINYAQPVKFQGFDVAEDENIHHHMSSFSETMALGLLKNQAIEFVNYNKRQMSRIYPRGNRVDSSNYMPQIFWNAGCQMVALNFQTPDLAMQLNQGKFEYNGNCGYLLKPEFMRRPERQFDPFSESPMDGVIAATCEVKIISGQFLSDRKVGTYVEVDMYGLPTDTIRKEFRTRVVPNNGLNPVYGDDAVFVFRKVVLPDLAVLRFAVYEDTGKLIGQRVLPLDGLQAGYRHISLRTEGNFPLSLPTLFCQVSLTTYVPEGLNDLVDALSDPRAFLSKEEQRMKQLASMGIDSSEIADV-PSTG--NAKRVGGVVGGSGTSGQLSGSALSSVSGSGDVANVSSNSTKKDDKKDDPKFDPISISLLQTDKIYQ--------------KLIKKQAKELEILQKRQEKDAVTMLRNHTIITDKLNTSHAKERSSTKRSINKENGQNAALEDTHRNQMCELVRQHTDQWSNLKSTQMKEVYDLVLSFFDTRKDLLVKIMKEVQEEQKRELRIIQDREVKEMKAQQTKASIESSRSVMNDRKLRNKAERDRRIRELNDYNTKRFIDQRKLQAQRHDK 1154

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. TrEMBL
Match: A0A074ZXA5 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Opisthorchis viverrini OX=6198 GN=T265_05106 PE=4 SV=1)

HSP 1 Score: 1298.88 bits (3360), Expect = 0.000e+0
Identity = 657/1228 (53.50%), Postives = 839/1228 (68.32%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDL-EIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMV--GDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHK-KKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            MTSDIAKRQRTVPS+K +EF WRR +P+ L+ GA FD  D+E   LE +C V+VD  GFF+ WK+E S++ + ++  ISDV++G K K+EK+++Q+Q++      DR + I    D VN+     I  + +   +W+  LRS+ HN KA N+CPMTQL+KHW+RL L VN  NKIP++++ KTFASGRNE++VFQSLKEL LP  K   ++P+ F FEKFY L + ICPRTDI+DLF SLS   D L  D+MI FLNETQRDPRLNEILYP++NR +++YI + YE     K+   +S++CFYRYLMSD NA VFLDRLD++Q+MDQPL+HYYINSSHNTYL+GRQF GKSSV+MYRQVLLAGCRC+ELDCWDG+G+DQEPIITHGKAMC+DILF+DVIYAIRD AFVTS YPV +SFENHCSK QQYK+AKYCE++LG+ LLTKPI+   LE G PLP PEKLK KILIKNKRL  E EK QL++FLKGQTD  Q+  +IAEDPDL    DG                                        F S + + P   S   E+    L  E+   S      SSN  +              SS+ DL  L +  G+ +AE   ++Q + + Y+HT  T+++HP LSS +NY QPVKF GF++  EK   FHMSSFSET +LG MKN AIE VNYNK Q+SRIYPRGNRVDSSN++PQIFWNAGCQMVALNFQ+ DLAMQLNQG+FEYN N GY+LKPEFMRR ER FDPFSESPMDGVIAATCEVKIISGQFLS++K+GTYVEVDMYGLPTDTIRKEFRTRVVP NGLNP+Y ED+ FVFRKV+LPDLAVLR  V+EETGKLIGQRV+PLDGLQ G+RHISLR+EGNFP +L +LFC++ L+TYVP+G    VDALSDPRA +S+EE ++K +A+MG ++SEI D+ P+T++     +            T++    G  +E                                   F+ I+   L   K   K LK+Q+KE   +Q+RQ K+   +L++H++ T+KL +   K++S   +  K EN     +      ++  L  +   +   L    +    +L L   +  KE  L+++ ++Q  Q++ LR+VQ+REVKEM  QQTK+S+E++R V+ D   +NKAERDRR+REL DYN KRF+DQR+ Q  + ++
Sbjct:    1 MTSDIAKRQRTVPSAKAFEFNWRRPVPDVLQNGAFFDRLDEETGTLETDCFVRVDPDGFFIYWKTENSDSQLLELSQISDVRAGSKPKEEKLIAQIQERGPGKSWDRIVTICSGLDLVNIIYTHMIAPEPETAAYWIQQLRSLTHNTKAVNVCPMTQLRKHWIRLTLSVNPKNKIPVRVIMKTFASGRNERVVFQSLKELGLPHGKNDVIEPAAFPFEKFYELYHKICPRTDIEDLFKSLSNNTDVLHADKMIEFLNETQRDPRLNEILYPFANRQTIKYIQENYETQEEYKNTDMLSIECFYRYLMSDNNACVFLDRLDVYQEMDQPLSHYYINSSHNTYLSGRQFGGKSSVEMYRQVLLAGCRCIELDCWDGRGEDQEPIITHGKAMCTDILFKDVIYAIRDTAFVTSEYPVIMSFENHCSKHQQYKLAKYCEDILGDMLLTKPIDGFPLEPGAPLPPPEKLKRKILIKNKRLKPEAEKQQLELFLKGQTDAIQEENDIAEDPDLTVDVDG---------------------------------------KFGSLLLHEPSARSCYSESGTKGLNGESGLSS------SSNTPAP---------PSGGSSSADLKRLQMKKGNLTAE---EEQMMMVQYQHTGATSSIHPLLSSFINYVQPVKFQGFDVAEEKNLHFHMSSFSETISLGLMKNQAIEYVNYNKRQMSRIYPRGNRVDSSNYMPQIFWNAGCQMVALNFQTPDLAMQLNQGKFEYNGNCGYLLKPEFMRRLERQFDPFSESPMDGVIAATCEVKIISGQFLSDRKVGTYVEVDMYGLPTDTIRKEFRTRVVPNNGLNPVYGEDAVFVFRKVVLPDLAVLRFAVYEETGKLIGQRVIPLDGLQAGYRHISLRTEGNFPLSLPTLFCQVNLTTYVPEGLNDLVDALSDPRAFLSKEEQRMKQLASMGIDSSEIADV-PTTTAKRTPASGAAAASGPPGAATEAGDASGAKKEEKKDD----------------------------PKFDPISLSLLQTDKNYQKLLKKQSKELELVQRRQDKDATAMLRNHTVVTDKLNTTHAKERSSTKRPSKKENGQSSVLEATQKSQLCELMRQQADQWTNLKVAQMKEICDLVLGYIEVRKELLLRIMKEVQEEQKRELRIVQEREVKEMRAQQTKASIESSRSVMNDRKLKNKAERDRRIRELNDYNTKRFIDQRKIQAQRQDK 1142

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. TrEMBL
Match: A0A4S2KEP2 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Opisthorchis felineus OX=147828 GN=CRM22_011021 PE=4 SV=1)

HSP 1 Score: 1294.64 bits (3349), Expect = 0.000e+0
Identity = 653/1226 (53.26%), Postives = 836/1226 (68.19%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDL-EIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHK-KKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            MTSDIAKRQRTVPS+K +EF WRR +P+ L+ GA FD  D+E   LE +C V+VD  GFF+ WK+E +++ + ++  ISDV++G K KDEK+++Q+Q++      DR + I    D VN+     I  + +   +W+  LRS+ HN KA N+CPMTQL+KHW+RL L VN  NKIP++++ KTFASGRNE++VFQSLKEL LP  K   ++P+ F FEKFY L + ICPRTDI+DLF SLS   D L  D+MI FLNETQRDPRLNEILYP++NR +++YI + YE     K+   +S++CFYRYLMSD NA VFLDRLD++Q+MDQPL+HYYINSSHNTYL+GRQF GKSSV+MYRQVLLAGCRC+ELDCWDG+G+DQEPIITHGKAMC+DILF+DVIYAIRD AFVTS YPV +SFENHCSK QQYK+AKYCE++LG+ LLTKPI+   LE G  LP PEKLK KILIKNKRL  E EK QL++FLKGQTD  Q+  +IAEDPDL    DG  +                         + +      R  +S S                G+  +   S S  T    S   S+  +K    L  KK           G+ +AE   ++Q + + Y+HT  T+++HP LSS +NY QPVKF GF++  EK   FHMSSFSET +LG MKN AIE VNYNK Q+SRIYPRGNRVDSSN++PQIFWNAGCQMVALNFQ+ DLAMQLNQG+FEYN N GY+LKPEFMRR ER FDPFSESPMDGVIAATCEVKIISGQFLS++K+GTYVEVDMYGLPTDTIRKEFRTRVVP NGLNP+Y ED+ FVFRKV+LPDLAVLR  V+EETGKLIGQRV+PLDGLQ G+RHISLR+EGNFP +L +LFC++ L+TYVP+G    VDALSDPRA +S+EE ++K +A+MG ++SEI D+ P+T++     +            T++    G  +E                                   F+ I+   L   K   K LK+Q+KE   +Q+RQ K+   +L++H++ T+KL +   K++S   +  K EN     +      ++  L  +   +   L    +    +L L   +  KE  L+++ ++Q  Q++ LR+VQ+REVKEM  QQTK+S+E++R V+ D   +NKAERDRR+REL DYN KRF+DQR+ Q  + ++
Sbjct:    1 MTSDIAKRQRTVPSAKAFEFNWRRPVPDVLQNGAFFDRLDEETGTLETDCFVRVDPDGFFIYWKTENTDSQLLELSQISDVRAGSKPKDEKLIAQIQERGPGKSWDRIVTICSGLDLVNIIYTHMIAPEPETAAYWIQQLRSLTHNTKAVNVCPMTQLRKHWIRLTLSVNPKNKIPVRVIMKTFASGRNERVVFQSLKELGLPHGKNDVIEPAAFPFEKFYELYHKICPRTDIEDLFKSLSNNTDVLHADKMIEFLNETQRDPRLNEILYPFANRQTIKYIQENYETQEEYKNTDMLSIECFYRYLMSDNNACVFLDRLDVYQEMDQPLSHYYINSSHNTYLSGRQFGGKSSVEMYRQVLLAGCRCIELDCWDGRGEDQEPIITHGKAMCTDILFKDVIYAIRDTAFVTSEYPVIMSFENHCSKHQQYKLAKYCEDILGDMLLTKPIDGFPLEPGASLPPPEKLKRKILIKNKRLKPEAEKQQLELFLKGQTDAIQEENDIAEDPDLTVDVDGKFD-------------------------WLLLHGPSARACYSES-------------GTKGLNGESGLSSSSNTPAPPSGGSSSADLKR---LQMKKEE---------GNLTAE---EEQIMMVQYQHTGATSSIHPLLSSFINYVQPVKFQGFDVAEEKNLHFHMSSFSETISLGLMKNQAIEYVNYNKRQMSRIYPRGNRVDSSNYMPQIFWNAGCQMVALNFQTPDLAMQLNQGKFEYNGNCGYLLKPEFMRRLERQFDPFSESPMDGVIAATCEVKIISGQFLSDRKVGTYVEVDMYGLPTDTIRKEFRTRVVPNNGLNPVYGEDAVFVFRKVVLPDLAVLRFAVYEETGKLIGQRVIPLDGLQAGYRHISLRTEGNFPLSLPTLFCQVNLTTYVPEGLNDLVDALSDPRAFLSKEEQRMKQLASMGIDSSEIADV-PTTTAKRTPASGVAAASGPPGAATEAGDASGAKKEEKKDD----------------------------PKFDPISLSLLQTDKNYQKLLKKQSKELELVQRRQDKDATAMLRNHTVVTDKLNTTHAKERSSTKRPSKKENGQSSVLEATQKSQLCELMRQQADQWTNLKVTQMKEICDLVLGYIEVRKELLLRIMKEVQEEQKRELRIVQEREVKEMRAQQTKASIESSRSVMNDRKLKNKAERDRRIRELNDYNTKRFIDQRKIQAQRQDK 1144

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. TrEMBL
Match: A0A0X3P0N3 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Schistocephalus solidus OX=70667 GN=TR168281 PE=4 SV=1)

HSP 1 Score: 1287.71 bits (3331), Expect = 0.000e+0
Identity = 649/1230 (52.76%), Postives = 849/1230 (69.02%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDK-TQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTD-LTQDLEIAEDPDLIA---GEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKS-IMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            M+SDIAKRQRTVPS+K+Y+F WRR +P  L++GA FD +D+E  I+E+ C ++VDE GFFL WKSE +E  V ++  +SDV+ G K KDEKV+S L ++     +++R + +    D VN+    F+    ++  +W+ S+R + HN KA N+CPMTQL+KHWLR+ L VN   KIP+++V KTFASGRNE+++FQSLKEL LP  K  +V+PS+FTFE+FY L + ICPRTDI++LF SLS GK  +++++M+ FLNE QRDPRLNEILYPY+NR +++YI + YE      SQ  ++++CFYRYLMSD+NAPVFLDRLD++QDMDQPL HYYINSSHNTYL GRQF GKSSV++YRQVLLAGCRC+ELDCWDGKGDDQEPIITHGKAMC+DILF+DVIYA+RD AFVTS  PV +SFENHCSK QQ+K+AKYCE++LG+ LLTKPI+KH LE G PLPSPEKLK KIL+KNKRL  + EK QL++FLKGQTD + ++ E ++  D IA   GE G LN                                        ++P  P+      E      K    S + I  +  S   S++  +  +   ++  + K+  SL V +E A + +        Y +T  TT +HP LSS+VNYAQ VKF GF++  E+   FH+SSF+E  ALG +K    E V YNK Q+SRIYPRGNRVDSSN++PQIFWNAGCQMVALNFQ+ DLAMQLNQGRFEYN N G++LKPEFMRR ER FDPFSESPMDGVIAATCEV+IISGQFLS++K+GTYVEVDMYGLPTDTIRKEFRTRVVP NGLNP+Y ED+ FVFRKV+LPDLAVLR  V+E+TGKLIGQRVLPLDGLQ+G+RHISLR+EGNFP +L +LFC+++L+TYVP+G    VDALSDPRA +S+EE ++K +A+MG ++SEI D+  +T SL +        R   T  +      GI++ + T+   SNV            + +K ++ ++D  F  I+   L   K   K +K+Q K+   L++R  KE + +L++H++ T+KL +   K  + I    +  N +   +      EM  L  +   + + L    +    +L L      KE  LKVL +    Q++ L+ +Q+RE KEM  QQTK S+E+NR V+ D   +NKAERDRR+REL DYN KRF+DQR+AQ  ++ R
Sbjct:    1 MSSDIAKRQRTVPSAKVYDFVWRRPVPPALREGAYFDRFDEETGIVELGCFLRVDEDGFFLFWKSEANEGQVLELSQVSDVRQGCKPKDEKVVSILTERFANRPLDERVMTVCSGLDLVNISYTNFVASTPEVAAWWIQSVRGLTHNTKAQNVCPMTQLRKHWLRITLTVNPRGKIPVRVVTKTFASGRNERIIFQSLKELGLPSGKNDEVEPSEFTFERFYELYHKICPRTDIEELFKSLSNGKPTISHEKMMEFLNEVQRDPRLNEILYPYANRQTIRYIQEAYEPQEKSASQDGLTLECFYRYLMSDDNAPVFLDRLDIYQDMDQPLCHYYINSSHNTYLIGRQFGGKSSVEIYRQVLLAGCRCIELDCWDGKGDDQEPIITHGKAMCTDILFKDVIYAVRDTAFVTSDCPVIMSFENHCSKHQQFKLAKYCEDILGDLLLTKPIDKHPLEPGYPLPSPEKLKRKILVKNKRLTPDVEKHQLELFLKGQTDPIQEETESSDLADTIACVDGEVGPLN------------------------------------DLDPTMPPKPLDIDPHPET-----KSRPGSGTTINTLSPSG--SSLPCRLSEAEMKRLVNKKEEGSLTVEEEQAMLAQ--------YHYTGATTAIHPLLSSMVNYAQAVKFQGFDVAEERNLSFHVSSFNENRALGLIKCYCTEFVVYNKRQMSRIYPRGNRVDSSNYMPQIFWNAGCQMVALNFQTPDLAMQLNQGRFEYNGNCGFLLKPEFMRRPERQFDPFSESPMDGVIAATCEVRIISGQFLSDRKVGTYVEVDMYGLPTDTIRKEFRTRVVPNNGLNPVYGEDAVFVFRKVVLPDLAVLRFAVYEDTGKLIGQRVLPLDGLQSGYRHISLRTEGNFPLSLPTLFCRVSLTTYVPEGLNDLVDALSDPRAFLSKEEQRMKQLASMGIDSSEIADVPATTKSLKRSGQS----RVGVTVNSSCPSSCGIDRPAGTSTSASNV------------NSSKKEEKREDPKFPGISLGMLRNDKNYRKLVKKQAKDLELLRRRHEKEASTMLRAHTILTDKLNAAHAKASAGIKAAAQKSNGVNSQLKDLQKSEMSDLVRQQTDQWSSLKAQQMKEVHHLVLTFMDARKELLLKVLREAHEDQKRELKQIQERENKEMKAQQTKISIESNRTVLGDRKLKNKAERDRRIRELNDYNTKRFIDQRKAQAQRNER 1163

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. TrEMBL
Match: A0A0R3U5L3 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Mesocestoides corti OX=53468 GN=MCOS_LOCUS2018 PE=4 SV=2)

HSP 1 Score: 1281.93 bits (3316), Expect = 0.000e+0
Identity = 660/1295 (50.97%), Postives = 855/1295 (66.02%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQS---NIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQ-DLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKL---------------------------MANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGI--------------------------NQESSTTKINS------NVYQIKVRNENLVYSPNKSK--DFK-DDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQ-----KSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            M+SDIAKRQRTVPSSK Y+F WRR +P  L++G  FD +D+E   LE+ C ++VDE GFFL WKS+ +E  V ++  +SDV+ G+K KDEK+++ L ++  S   N+++  + +    D VN+    F+    ++ + W+ S+R + HN KA N+CPMTQL+KHWLRL L VN   KIP+++V KTFASGRNE+++FQSLKEL LP  K  +V+PS+FTFE+FY L + ICPRTDI++LF +LS GK+ LT ++MI FLNE QRDPRLNEILYPY+NR +++YI +TYE      S   +S+  FYRYLMSD+NAPVFLDRLD+ QDMDQPL HYYINSSHNTYL GRQF GKSSV++YRQVLLAGCRC+ELDCWDGKG+DQEPIITHGKAMCSDILF+DVIYA+RD AFVTS YP+ +SFENHCSK QQYK+AKYCE++LG+ LLTKP++K+ LEAGVPLPSPEKLK KILIKNKRL  + EK QL++F+KGQ D  Q D ++AEDPD +   D  +  ++                       +I    +T+    S   N    +  +  + IG L  ET     ITK  S  AE                                   ++Q +   Y +T  T  +HP LSS+VNYAQPVKF GF++  ++   +HMSSFSET ALG MKN+AIE VNYNK Q+SRIYPRGNRV+SSN++PQIFWNAGCQMVALNFQ+ DLAMQLNQG+FEYN N GY+LKPEFMRR ER FDPFSESPMDGVIAATCEV+IISGQFLS++K+GTYVEVDMYGLPTDTIRKEFRTRVVP NGLNP+Y ED+ FVFRKV+LPDLAVLR  V+E+TGKLIGQRVLPLDGLQ+G+RHISLR+EGNFP +L +LFC+++L+TYVP+G    VDALSDPRA +S+EE ++K                            +A+MG ++SEI D+  S++ L     ++ +     ++   +N   G+                          +Q+S+ + + S          + V       S N +K  D K +D  F  I+   L   K   K +K+Q KE   LQ+R  KE   +L++H+L T+KL S   K       S+    +  N +   M +  I +M  L  +   E +KL +  +N    L L      K+  LK+L      Q++ L+ +Q+RE K+M  QQ K S+++NR V+ D   +NKAERDRR+REL DYN KRF+DQR+AQ  +++R
Sbjct:    1 MSSDIAKRQRTVPSSKAYDFVWRRPVPAALREGTYFDRFDEETGTLELGCFLRVDEDGFFLFWKSDVNEGQVLELSQVSDVRHGMKPKDEKLVATLTERVSSIGKNLDEHIVTVCSGLDLVNISYTNFVATSPEVASLWIQSVRGLTHNTKAQNVCPMTQLRKHWLRLTLTVNPRGKIPVRVVTKTFASGRNERIIFQSLKELGLPSGKNDEVEPSEFTFERFYELYHKICPRTDIEELFKTLSNGKETLTIEKMIEFLNEVQRDPRLNEILYPYANRQTIRYIQETYESRDENTSSDTLSLKGFYRYLMSDDNAPVFLDRLDICQDMDQPLCHYYINSSHNTYLIGRQFGGKSSVEIYRQVLLAGCRCIELDCWDGKGEDQEPIITHGKAMCSDILFKDVIYAVRDTAFVTSDYPLIMSFENHCSKHQQYKLAKYCEDILGDMLLTKPLDKYPLEAGVPLPSPEKLKRKILIKNKRLEPDVEKHQLELFMKGQADPVQEDDDVAEDPDPVVTPDCDVGPMNG----------------------DIDPHPETKLRPGSGQINVLSTSLPLSSSLIGKL-SETEMKRLITKKGSLTAE-----------------------------------EEQAMLAQYHYTGATKTIHPLLSSMVNYAQPVKFQGFDVAEDENVHYHMSSFSETVALGLMKNEAIEFVNYNKRQMSRIYPRGNRVESSNYMPQIFWNAGCQMVALNFQTPDLAMQLNQGKFEYNGNCGYLLKPEFMRRPERQFDPFSESPMDGVIAATCEVRIISGQFLSDRKVGTYVEVDMYGLPTDTIRKEFRTRVVPNNGLNPVYGEDAVFVFRKVVLPDLAVLRFAVYEDTGKLIGQRVLPLDGLQSGYRHISLRTEGNFPLSLPTLFCRVSLTTYVPEGLNDLVDALSDPRAFLSKEEQRMKQVGILLEPVALLLLHMFTIPISVTSHLKLASMGIDSSEIDDVPTSSTKLAAMLKQRPMGMGNLSNAPSANSAAGLLPSGVGSVAAASSAGLTLPGVGASADHQKSTGSTVVSPSANPLTSGGVGVSGATSGPSANSAKKEDKKAEDPKFPPISLSMLRSDKNYRKLVKKQAKELEALQRRHEKEAAAMLRAHTLLTDKLNSSHAKAIASSTSSLRSTPQKMNGINTPMKEAHIAQMNDLVRQQTDEWSKLKYTQMNEIHGLVLTFMDARKDLLLKILRDAHDEQKRLLKQIQERENKDMKAQQIKISLDSNRNVMNDPRLKNKAERDRRIRELKDYNTKRFIDQRKAQAQRNDR 1237

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Cavefish
Match: PLCB4 (phospholipase C beta 4 [Source:NCBI gene;Acc:103022380])

HSP 1 Score: 1145.57 bits (2962), Expect = 0.000e+0
Identity = 604/1231 (49.07%), Postives = 810/1231 (65.80%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINR-LKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMH-------KKKTENQMKIDMNQRSIQ----------EMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +K YEF W++++P+ L++GA+FD  D++  + E +CL KVDEFGFFL+WKSE  E  V +  LI+ V+ G   KD K+LS L+   K ++++E   + +    D VNL  +  +  ++     W+  L+SV HN KA N+CPMT LKKHW+RL  L NVN KIP++ + +TF SG+ EK +FQ+LKEL LP  K  ++D S FTF+ FY L   ICPRTDI++LF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +   V  I++ YE +   K +G +S D F RYLMSDENAPVFLDRLD+ QDMDQPLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLL+GCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSKPQQYK+AKYCE++ GE LL +P+E   +E   PLPSP  LK KILIKNKRL  E E+ QL+ F +                    E G ++V   +D++++D +     E+N  +K+         + +  +SV    I +  I E +                 E++ A+ T +           S A DL +   G ++ E    +Q +  +Y++   TTN+HPYLS++VNYAQPVKF  F I  EK    +MSSF+E+  LG++K +AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LNFQ+ DLAMQLNQG+FEYN   GY+ KP+FMRRS+R FDPFSE+P+DGVIAATC V++ SGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP Y E+  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF + VDALSDP+  +S  E +   M  +G ETS+I D+ P+ SS N K+ K   ++   T  T S+M     Q S+ T+ NS                  S+  KD A+  ++T E L + K+ VK +K+Q KE + L+KR  K+ N + KSH    +K+ +   K+K  +        KK+ EN       + +I+          ++  +  ++ +E +++  +H   EQ +K  +  Q  E   K+LS +Q  Q   L+LV +R+ KEM   Q K+SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MKH++
Sbjct:    2 TKSYEFNWQKHVPDFLQEGAVFDRLDEDPFVFESSCLFKVDEFGFFLTWKSEGKEGQVLECSLINSVRVGAVPKDPKILSSLEAAGKNEADLEGCIICVCSGPDLVNLSFMYMVADNADTAKKWLEGLKSVIHNFKANNVCPMTCLKKHWMRLSFLTNVNGKIPVRGITRTFGSGKTEKGIFQALKELGLPSGKNDEIDHSMFTFDVFYALTQKICPRTDIEELFKKINGDKTDYLTVDQLVSFLNENQRDPRLNEILFPFYDPKRVMQIIEKYERDEDLKKKGRMSSDGFCRYLMSDENAPVFLDRLDMCQDMDQPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLSGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKPQQYKMAKYCEDIFGELLLKQPLEGFPIEPARPLPSPNDLKRKILIKNKRLKPEVEQKQLESFKRHM------------------EAGEMSVQGGDDENEEDMENADSKEVNSDMKTRNTSEEPSEQDTQENSVKKDKIPDDEITEIS-----------------EATEADVTDL-----------SEASDLDNKKKGGDAPEDADAEQQLIASYKYEGATTNIHPYLSAMVNYAQPVKFQSFEIAEEKNIHHNMSSFNESVGLGYLKTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGACGYLQKPDFMRRSDRMFDPFSETPVDGVIAATCSVQVFSGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPAYNEEP-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGAIVDALSDPKKFLSIAEKRADQMRALGIETSDIADV-PNESSKNDKKGKVNQVKANVTPQTSSDM----GQTSTATQNNS------------------SETKKDSALVNQVTIEDLKQMKSYVKLIKKQQKELNALKKRHAKDHNAMQKSHCTQVDKMVAQHDKEKFTLEKLLEKAIKKRGENNCSELKKETAIKVENLTTDHKAKVKDIVAQHTKEWSEMINSHSTEEQEMKDAHVTQQCEHLKKLLSSVQEQQTMQLKLVHERQSKEMKANQAKTSMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKHSK 1162

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Cavefish
Match: PLCB4 (phospholipase C beta 4 [Source:NCBI gene;Acc:103022380])

HSP 1 Score: 1141.33 bits (2951), Expect = 0.000e+0
Identity = 602/1231 (48.90%), Postives = 810/1231 (65.80%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINR-LKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMH-------KKKTENQMKIDMNQRSIQ----------EMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +K YEF W++++P+ L++GA+FD  D++  + E +CL KVDEFGFFL+WKSE  E  V +  LI+ V+ G   KD K+LS L+   K ++++E   + +    D VNL  +  +  ++     W+  L+SV HN KA N+CPMT LKKHW+RL  L NVN KIP++ + +TF SG+ EK +FQ+LKEL LP  K  ++D S FTF+ FY L   ICPRTDI++LF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +   V  I++ YE +   K +G +S D F RYLMSDENAPVFLDRLD+ QDMDQPLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLL+GCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSKPQQYK+AKYCE++ GE LL +P+E   +E   PLPSP  LK KILIKNKRL  E E+ QL+ F +                    E G ++V   +D++++D +     E+N  +K+         + +  +SV    I +  I E +                 E++ A+ T + +     ++KK           GD   + + + Q +  +Y++   TTN+HPYLS++VNYAQPVKF  F I  EK    +MSSF+E+  LG++K +AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LNFQ+ DLAMQLNQG+FEYN   GY+ KP+FMRRS+R FDPFSE+P+DGVIAATC V++ SGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP Y E+  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF + VDALSDP+  +S  E +   M  +G ETS+I D+ P+ SS N K+ K   ++   T  T S+M     Q S+ T+ NS                  S+  KD A+  ++T E L + K+ VK +K+Q KE + L+KR  K+ N + KSH    +K+ +   K+K  +        KK+ EN       + +I+          ++  +  ++ +E +++  +H   EQ +K  +  Q  E   K+LS +Q  Q   L+LV +R+ KEM   Q K+SME ++ +  D + +NKAER+RR+REL   N K+FL++R+   MKH++
Sbjct:    2 TKSYEFNWQKHVPDFLQEGAVFDRLDEDPFVFESSCLFKVDEFGFFLTWKSEGKEGQVLECSLINSVRVGAVPKDPKILSSLEAAGKNEADLEGCIICVCSGPDLVNLSFMYMVADNADTAKKWLEGLKSVIHNFKANNVCPMTCLKKHWMRLSFLTNVNGKIPVRGITRTFGSGKTEKGIFQALKELGLPSGKNDEIDHSMFTFDVFYALTQKICPRTDIEELFKKINGDKTDYLTVDQLVSFLNENQRDPRLNEILFPFYDPKRVMQIIEKYERDEDLKKKGRMSSDGFCRYLMSDENAPVFLDRLDMCQDMDQPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLSGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKPQQYKMAKYCEDIFGELLLKQPLEGFPIEPARPLPSPNDLKRKILIKNKRLKPEVEQKQLESFKRHM------------------EAGEMSVQGGDDENEEDMENADSKEVNSDMKTRNTSEEPSEQDTQENSVKKDKIPDDEITEIS-----------------EATEADVTDLSEASDLDNKKKG----------GDAPEDADAEQQLIA-SYKYEGATTNIHPYLSAMVNYAQPVKFQSFEIAEEKNIHHNMSSFNESVGLGYLKTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGACGYLQKPDFMRRSDRMFDPFSETPVDGVIAATCSVQVFSGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPAYNEEP-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGAIVDALSDPKKFLSIAEKRADQMRALGIETSDIADV-PNESSKNDKKGKVNQVKANVTPQTSSDM----GQTSTATQNNS------------------SETKKDSALVNQVTIEDLKQMKSYVKLIKKQQKELNALKKRHAKDHNAMQKSHCTQVDKMVAQHDKEKFTLEKLLEKAIKKRGENNCSELKKETAIKVENLTTDHKAKVKDIVAQHTKEWSEMINSHSTEEQEMKDAHVTQQCEHLKKLLSSVQEQQTMQLKLVHERQSKEMKANQAKTSMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKHSK 1162

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Cavefish
Match: PLCB4 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [Source:NCBI gene;Acc:103033015])

HSP 1 Score: 1092.41 bits (2824), Expect = 0.000e+0
Identity = 586/1233 (47.53%), Postives = 794/1233 (64.40%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGS---KQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKI------DMNQRSIQEMLSLTEKNE-----------QEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +K YEF W+R +P+ L++GA FD +D++    E NC  +VD FGFF++WKSE  E  V +  LI+ ++S    KD K+LS L+   KT+S++E R + I   +D VNL  +  + +D  I   W  SLRS+ HN +A N+CPMT L+KHW+RL  L NVN KIP++ + +TFASG+ EK++FQ+LK+L LP  K  +++P  FTFEKFY+L   ICPRTDI+ LF  L  E  D+L  D+++ FLNE QRDPRLNEIL+P+ +    + I+++YE +   + +G +S D F RYLMSDENAPVFLDRL+L+Q+MDQPLAHY+I+SSHNTYLTGRQF G+SSV+MYRQVLL+GCRCVELDCWDGKG+DQEPIITHGKAMC+D+LF+DVI AI + AFV+S +PV LSFENHCS+ QQYK+A+YCE++ G+ LL +P++   LE G PLPSP  LK KILIKN+RL  E EK QL+ F K                    E G +N+ ++  +D++++DA     ++      ICG     QT  S    VP     N + + A + +L Q        T +E++  E                + K      V DE A I+        +Y + + TTN+HPYLS+++NYAQ VKFLGF    E     +MSSF+E+  LG+++ +AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LNFQ+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF + VDALSDP+  +S  E +   M  MG ET EI D+ P+ S             ++S  G  + +K    Q S  T+  S+        +N    P K      D    ++T E L + K  +K  K+Q KE + L+K+Q K    L +SH    +K+     K+K ++ K+  +N+ K+      +M +    +M ++T  ++           +E  ++   H    Q L+  +  Q  E   K++   Q  Q + L  + +R+ KEM   Q KSSM   R +  D + +NKAER+RR+REL   N ++FL +R+   M  ++
Sbjct:    2 AKAYEFNWQRAVPDCLQEGAYFDRFDEDPFAFESNCFFRVDAFGFFITWKSEGKEGQVLECSLINSIRSTSVPKDPKILSALEATGKTESDLEGRIICICSGADLVNLSFMYIVAQDISIAKQWTDSLRSLIHNSRANNVCPMTCLRKHWMRLSFLTNVNGKIPVRSITRTFASGKTEKVIFQALKDLGLPSGKNDELEPDAFTFEKFYSLSQKICPRTDIEVLFKKLCGEKSDFLNTDQLVSFLNENQRDPRLNEILFPFYDSKRARQIIESYETDEKLQKKGLMSCDGFSRYLMSDENAPVFLDRLELYQEMDQPLAHYFISSSHNTYLTGRQFGGRSSVEMYRQVLLSGCRCVELDCWDGKGEDQEPIITHGKAMCTDVLFKDVIQAIEETAFVSSEFPVILSFENHCSRHQQYKLARYCEDIFGDTLLRQPLDDFPLEPGQPLPSPNDLKRKILIKNRRLKPEVEKKQLEHFRKHM------------------EAGDVNMSTNMSEDENEEDAGCADLVDEAHPERICGRLVISQTN-SSEGDVPAADKGNKDEV-AGLEVLAQ--------TPLEAACQE----------------NGKKACEPGVADEQALIQ--------SYTYVAATTNIHPYLSNIINYAQAVKFLGFEEAEETNIHHNMSSFNESVGLGYLRTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRMFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEEP-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGAIVDALSDPKKFLSICEKRTDQMRAMGIETWEIADV-PNDSC------------KRSKKGKANQVKSLSPQRSLETRSTSS-------GQNASTFPKKDT----DTTMPQVTVEDLKQMKEYLKLAKKQVKELNALKKKQTKAHTALQRSHCTQMDKVVVQHEKEKRVLEKQLEKNKKKVSESNCCEMGREIEMKMKTITADHKTKVKDAAAAHAREWAEMMKAHSAEIQELRDQHVLQQCEQLRKLMLMTQEQQTQQLTHLHERQCKEMRANQAKSSMANGRAISQDKSIKNKAERERRVRELNSNNTRKFLTERKRLAMGQSK 1157

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Cavefish
Match: PLCB4 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [Source:NCBI gene;Acc:103033015])

HSP 1 Score: 1073.92 bits (2776), Expect = 0.000e+0
Identity = 581/1235 (47.04%), Postives = 781/1235 (63.24%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKG--QTDLTQDLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGS---KQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKI------DMNQRSIQEMLSLTEKNE-----------QEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +K YEF W+R +P+ L++GA FD +D++    E NC  +VD FGFF++WKSE                     KD K+LS L+   KT+S++E R + I   +D VNL  +  + +D  I   W  SLRS+ HN +A N+CPMT L+KHW+RL  L NVN KIP++ + +TFASG+ EK++FQ+LK+L LP  K  +++P  FTFEKFY+L   ICPRTDI+ LF  L  E  D+L  D+++ FLNE QRDPRLNEIL+P+ +    + I+++YE +   + +G +S D F RYLMSDENAPVFLDRL+L+Q+MDQPLAHY+I+SSHNTYLTGRQF G+SSV+MYRQVLL+GCRCVELDCWDGKG+DQEPIITHGKAMC+D+LF+DVI AI + AFV+S +PV LSFENHCS+ QQYK+A+YCE++ G+ LL +P++   LE G PLPSP  LK KILIKN+RL  E EK QL+ F K     D+     ++ED +    ED   ++V                  +      ICG     QT  S    VP     N + + A + +L Q        T +E++  E                + K      V DE A I+        +Y + + TTN+HPYLS+++NYAQ VKFLGF    E     +MSSF+E+  LG+++ +AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LNFQ+ DLAMQLNQG+FEYN + GY+LKP+FMRR +R FDPFSE+P+DGVIAATC V++ISGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP+Y E+  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF + VDALSDP+  +S  E +   M  MG ET EI D+ P+ S             ++S  G  + +K    Q S  T+  S+        +N    P K      D    ++T E L + K  +K  K+Q KE + L+K+Q K    L +SH    +K+     K+K ++ K+  +N+ K+      +M +    +M ++T  ++           +E  ++   H    Q L+  +  Q  E   K++   Q  Q + L  + +R+ KEM   Q KSSM   R +  D + +NKAER+RR+REL   N ++FL +R+   M  ++
Sbjct:    2 AKAYEFNWQRAVPDCLQEGAYFDRFDEDPFAFESNCFFRVDAFGFFITWKSEG--------------------KDPKILSALEATGKTESDLEGRIICICSGADLVNLSFMYIVAQDISIAKQWTDSLRSLIHNSRANNVCPMTCLRKHWMRLSFLTNVNGKIPVRSITRTFASGKTEKVIFQALKDLGLPSGKNDELEPDAFTFEKFYSLSQKICPRTDIEVLFKKLCGEKSDFLNTDQLVSFLNENQRDPRLNEILFPFYDSKRARQIIESYETDEKLQKKGLMSCDGFSRYLMSDENAPVFLDRLELYQEMDQPLAHYFISSSHNTYLTGRQFGGRSSVEMYRQVLLSGCRCVELDCWDGKGEDQEPIITHGKAMCTDVLFKDVIQAIEETAFVSSEFPVILSFENHCSRHQQYKLARYCEDIFGDTLLRQPLDDFPLEPGQPLPSPNDLKRKILIKNRRLKPEVEKKQLEHFRKHMEAGDVNMSTNMSEDEN---EEDAGCDLV------------------DEAHPERICGRLVISQTN-SSEGDVPAADKGNKDEV-AGLEVLAQ--------TPLEAACQE----------------NGKKACEPGVADEQALIQ--------SYTYVAATTNIHPYLSNIINYAQAVKFLGFEEAEETNIHHNMSSFNESVGLGYLRTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRMFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEEP-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGAIVDALSDPKKFLSICEKRTDQMRAMGIETWEIADV-PNDSC------------KRSKKGKANQVKSLSPQRSLETRSTSS-------GQNASTFPKKDT----DTTMPQVTVEDLKQMKEYLKLAKKQVKELNALKKKQTKAHTALQRSHCTQMDKVVVQHEKEKRVLEKQLEKNKKKVSESNCCEMGREIEMKMKTITADHKTKVKDAAAAHAREWAEMMKAHSAEIQELRDQHVLQQCEQLRKLMLMTQEQQTQQLTHLHERQCKEMRANQAKSSMANGRAISQDKSIKNKAERERRVRELNSNNTRKFLTERKRLAMGQSK 1136

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BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Cavefish
Match: PLCB4 (phospholipase C beta 4 [Source:NCBI gene;Acc:103022380])

HSP 1 Score: 588.571 bits (1516), Expect = 0.000e+0
Identity = 278/476 (58.40%), Postives = 354/476 (74.37%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQ--DKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMF 1699
            +K YEF W++++P+ L++GA+FD  D++  + E +CL KVDEFGFFL+WKSE  E  V +  LI+ V+ G   KD K+LS L+   K ++++E   + +    D VNL  +  +  ++     W+  L+SV HN KA N+CPMT LKKHW+RL  L NVN KIP++ + +TF SG+ EK +FQ+LKEL LP  K  ++D S FTF+ FY L   ICPRTDI++LF  ++  K DYLT D+++ FLNE QRDPRLNEIL+P+ +   V  I++ YE +   K +G +S D F RYLMSDENAPVFLDRLD+ QDMDQPLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLL+GCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSKPQQYK+AKYCE++ GE LL +P+E   +E   PLPSP  LK KILIKNKRL  E E+ QL+ F
Sbjct:    2 TKSYEFNWQKHVPDFLQEGAVFDRLDEDPFVFESSCLFKVDEFGFFLTWKSEGKEGQVLECSLINSVRVGAVPKDPKILSSLEAAGKNEADLEGCIICVCSGPDLVNLSFMYMVADNADTK--WLEGLKSVIHNFKANNVCPMTCLKKHWMRLSFLTNVNGKIPVRGITRTFGSGKTEKGIFQALKELGLPSGKNDEIDHSMFTFDVFYALTQKICPRTDIEELFKKINGDKTDYLTVDQLVSFLNENQRDPRLNEILFPFYDPKRVMQIIEKYERDEDLKKKGRMSSDGFCRYLMSDENAPVFLDRLDMCQDMDQPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLSGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKPQQYKMAKYCEDIFGELLLKQPLEGFPIEPARPLPSPNDLKRKILIKNKRLKPEVEQKQLESF 475

HSP 2 Score: 499.975 bits (1286), Expect = 1.855e-154
Identity = 258/474 (54.43%), Postives = 330/474 (69.62%), Query Frame = 2

Query: 2087 SLMVGDESAE--IEKD-DQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHK 3499
            S+  GD+  E  +E D +Q +  +Y++   TTN+HPYLS++VNYAQPVKF  F I  EK    +MSSF+E+  LG++K +AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LNFQ+ DLAMQLNQG+FEYN   GY+ KP+FMRRS+R FDPFSE+P+DGVIAATC V++ SGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP Y E+  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC I L TYVPDGF + VDALSDP+  +S  E +   M  +G ETS+I D+ P+ SS N K+ K   ++   T  T S+M     Q S+ T+ NS+  +    N+   YS                         + VK +K+Q KE + L+KR  K+ N + KSH    +K+ +   K+K  + K
Sbjct:  485 SVQGGDDENEEDMENDAEQQLIASYKYEGATTNIHPYLSAMVNYAQPVKFQSFEIAEEKNIHHNMSSFNESVGLGYLKTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGACGYLQKPDFMRRSDRMFDPFSETPVDGVIAATCSVQVFSGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPAYNEEP-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGAIVDALSDPKKFLSIAEKRADQMRALGIETSDIADV-PNESSKNDKKGKVNQVKANVTPQTSSDM----GQTSTATQNNSSETKKGEENQCTDYS-----------------------IVSYVKLIKKQQKELNALKKRHAKDHNAMQKSHCTQVDKMVAQHDKEKFTLEK 929

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Sea Lamprey
Match: PLCB4 (phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGNC:9059])

HSP 1 Score: 521.546 bits (1342), Expect = 1.145e-168
Identity = 272/594 (45.79%), Postives = 375/594 (63.13%), Query Frame = 2

Query: 2117 IEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXX----------------------XXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDR 3832
            +E +D  V   Y++T GTTN+HPYLS+LVNYAQPVKF  F +  E+   ++MSSF+E+  LG++K  AIELVNYNK Q+SRIYPRG RVDSSN++PQIFWNAGCQMV+LNFQ+ DLAMQLNQG+FEYN   G++LKP+FMRR +R FDPFSE+P+DGVIA TC V++ISGQFLS++++GTYVEVDMYGLPTDTIRKEFRTR+VP NGLNPLY ++  FVFRKVILPDLAVLRI VF+++ KLIGQR+LPLDGLQTG+RHISLR+EGN P +L ++FC I L TYVPDGF  FVDALSDP+  +S+ E +   M  MG E S+I D+  S  S+N+                           ++T + +     + VR+       N      D+ +   +  ++L  +K+ +K LK+Q KE + L+K   K    L K+++   +K+ S   +++S + K     Q +  + ++       L ++ E+   +L   H    Q                        +  +  Q  E    +L+     Q + L+L  +R+ K++   Q K SME ++++  D + +NKAER+R
Sbjct:    2 VESEDAWVSA-YKYTGGTTNIHPYLSALVNYAQPVKFQNFVVAEERNIHYNMSSFNESVGLGYLKTGAIELVNYNKRQMSRIYPRGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGFCGFLLKPDFMRRPDRTFDPFSETPVDGVIAGTCSVQVISGQFLSDRQVGTYVEVDMYGLPTDTIRKEFRTRLVPNNGLNPLYNQEP-FVFRKVILPDLAVLRIAVFDDSNKLIGQRILPLDGLQTGYRHISLRNEGNKPLSLPTVFCNIVLKTYVPDGFGDFVDALSDPKRFLSQAEKRANQMQAMGIEASDIGDVPESRGSVNRG--------------------------AATPQTSVTCTPVTVRS----LGNNAIGSTPDEPLVPPVCVDTLRHSKSFLKLLKKQEKEMTLLKKAHAKAQASLQKTYTGQGDKVTSQYERERSSILK-----QTEKTLAKKGEGHCAGLQKETEKRVEELTVEHQRKTQALQAERAREQAALQAQQARRQEEARTAHAAQQDELVRALLAGAHEQQIRQLQLTHERDTKQLEGTQAKQSMEESKLISQDRSIKNKAERER 558

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Sea Lamprey
Match: PLCB1 (phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917])

HSP 1 Score: 360.147 bits (923), Expect = 3.592e-105
Identity = 202/495 (40.81%), Postives = 286/495 (57.78%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDS--------NMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAI------FEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKT-ENQMK----------IDMNQRSIQEMLSLTEKN-EQEKNK 3595
            +S+LVNY QPVKF  F    +K   + MSSF ET  +  +    +E V YNK QLSRIYP+G RVDSSN++PQ+FWNAGCQ+VALN+Q+ DLAMQLN G FEYN  SGY+LKPEFMRRS++ FDPFS++ +DG+IA T  VK+ISGQFLS+KK+G +VEVDM+GLP DT RK ++T+  P N +NP++ E+  FVF+KV+LP LA LR+  FE+ GK +G R++P+  ++ G+RHI LR+E N   AL ++   I +  YVPD FA   +AL++P  ++S  E + + +A +      I +    T+ +           R + DG  S            G  Q S  T              + V SP K    KDD +       E +T E + + K ++K   +Q+KE  +L KR  K I EL K        L++ L K    M    + E ++            +M Q+  +EML + +++ E EK +
Sbjct:  512 MSNLVNYVQPVKFTTFEAARKKNRSYEMSSFVETKGMEQLTKCPVEFVEYNKCQLSRIYPKGTRVDSSNYMPQVFWNAGCQLVALNYQTMDLAMQLNIGMFEYNRRSGYILKPEFMRRSDKHFDPFSDNTVDGIIANTVSVKVISGQFLSDKKVGCFVEVDMFGLPVDTKRKIYKTKTAPGNSINPVWDEEP-FVFKKVVLPTLACLRVAAFEDGGKFLGHRIMPVSAIRPGYRHICLRNESNQALALPAILVYIQVKDYVPDAFADLTEALANPIRYVSLMEQRAQQLAAL------IGEFDEGTAEV-----------RMAHDGPISMPPAPHKVAAPPGAPQGSGPT--------------DTVKSPAKPPPQKDDVLASILRGVEALTVEQIKQHKAVLKLQFKQHKEAKDLSKRHQKRIAELAKEQMARLSDLQAELKKCHPTMSPSASLEGELSALEGQGGRQITEMKQQQQEEMLHMRQEHCELEKAR 974

HSP 2 Score: 337.421 bits (864), Expect = 2.246e-97
Identity = 166/366 (45.36%), Postives = 233/366 (63.66%), Query Frame = 2

Query:  539 QSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKP-QQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKL 1630
            +  +E +T+ +   SDFVNL  L F+    +I   W T +  +  N+   N      L K + +L L +N ++KIP+K + + FA+ R  + V  +L+   LP  +   + P++F  + F   +  ICPR +I  +F  + +  + YLT D+   F+N  QRDPRLNEILYP    + VQ +++ YE N     +G ISV  F ++L  DEN+ +  +++DL  DM QPL+HY+INSSHNTYL   Q  G SSV+MYRQ LLAGCRCVELDCW G+  D+EP+ITHG  M ++ILF+DVI AI+DCAF TSP+PV LSFENH   P QQ K+A+YC  + G+ LL  P+EK+ LE+G+PLPSP+ L
Sbjct:   15 EGRLEQKTVTVVFGSDFVNLTFLNFVAFSEEIAKEWATGIFQLASNLLYHNSSRDIFLDKLYTKLTLQLNQDSKIPVKNICRLFAADR--RRVETALESCGLPNGRNDAIYPAEFGPDVFRLFIKSICPRPEIDGIFAEVGARSRPYLTVDQFTEFINNCQRDPRLNEILYPPLKPSQVQLMIEKYEPNASLAKKGHISVGGFLKFLQGDENSAIPAEKIDLSDDMMQPLSHYFINSSHNTYLMAGQLAGSSSVEMYRQALLAGCRCVELDCWKGRTADEEPVITHGFTMTTEILFKDVIEAIKDCAFKTSPFPVILSFENHVDSPKQQAKMAEYCRTIFGDALLMDPLEKYLLESGIPLPSPQDL 378

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Sea Lamprey
Match: PLCB1 (phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGNC:15917])

HSP 1 Score: 333.954 bits (855), Expect = 5.743e-95
Identity = 159/293 (54.27%), Postives = 210/293 (71.67%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPA-NGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANM 3064
            +S+LVNY QP+KF  F    ++   + MSSF E+  +  +    +E V YNK QLSRIYP+G RVDSSN++PQ+FWNAGCQMVALN+Q+ DLAMQLN G FEYN  SGY+LKPEFMRR+++ FDPF++  +DGVIA T  VK+ISGQFLS++K+ TYVEVDM+GLP DT RK ++TR     N +NP++ ED  FVF KV+LP LA LRIGVFEE GK IG R+LP+  ++ GF HI LR+E N P +L ++F  I +  YVP  F +F+  LS+P  +    E + K + ++
Sbjct:  510 MSNLVNYVQPIKFDSFEDAKKRNRNYEMSSFVESKGMEQLTKCPVEFVEYNKTQLSRIYPKGTRVDSSNYMPQVFWNAGCQMVALNYQTLDLAMQLNMGIFEYNCRSGYLLKPEFMRRADKQFDPFTQDIIDGVIANTISVKVISGQFLSDRKVSTYVEVDMFGLPVDTKRK-YKTRTSKDNNSINPVWEEDP-FVFDKVVLPSLASLRIGVFEEGGKFIGHRILPVSAIRPGFHHICLRNESNQPLSLPAIFVFIQVKDYVPVAFENFISGLSNPIMYQGLMEQRAKQLESL 800

HSP 2 Score: 326.25 bits (835), Expect = 1.854e-92
Identity = 167/381 (43.83%), Postives = 239/381 (62.73%), Query Frame = 2

Query:  497 IKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKD--YLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKP-QQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKL 1630
            ++D K   Q++  T   +E RT+ +    D VN+  L F      +   W   L ++  N+ A N      L K + +L L  N  +K+P++ + + F +  ++K V  +L    LP  +  ++    FT+E FY+ +N +CPRTDI  +F     G+    +T ++   F+N  QRDPRLNE+L+P    + VQ ++D +E   + K +G+ISV  F RYL  +EN  V  ++LDL++DM QPL+HY+INSSHNTYLTG Q +G SSV+MYRQ LLAGCRCVELDCW G+  D++PIITHG  M ++I F++VI AI + AF TSPYPV LSFENH   P QQ K+A+YC  + G+ LL   ++K+ LE+GVPLPSPE+L
Sbjct:    2 VQDTKFRDQVEGFTGVGMESRTITVVHGPDLVNISFLNFTALTESVAKVWTDELFTLATNLLAQNSSRDKFLNKAYTKLKLQSNTEDKVPVRSILRMFPT--DKKKVENALMSCELPSGRNDNIPIETFTYEAFYSFVNKLCPRTDIDSIFAERYGGQASAXMTVEQFTDFINSKQRDPRLNEVLFPPMKTHQVQALIDKFESTNLAK-KGQISVLGFLRYLNGEENGIVPPEKLDLNEDMTQPLSHYFINSSHNTYLTGGQLKGNSSVEMYRQSLLAGCRCVELDCWKGRTADEDPIITHGFTMTTEIPFKEVIDAIAETAFKTSPYPVVLSFENHVDSPKQQAKMAEYCRLMFGDALLVDVLDKYPLESGVPLPSPEEL 379

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Sea Lamprey
Match: PLCD4 (phospholipase C delta 4 [Source:HGNC Symbol;Acc:HGNC:9062])

HSP 1 Score: 196.438 bits (498), Expect = 6.862e-53
Identity = 114/266 (42.86%), Postives = 159/266 (59.77%), Query Frame = 2

Query:  887 FEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLD-LHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMY--RQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVP---LPSPEKLKYKILIKNKRLP 1666
            F  FY LL     R ++Q LF+SLS     L+   +  FL + QR+    E+ +     +S   I + +EL+ + +S   +++D F RYL S + + ++  R D +  DM +PL+HY+I+SSHNTYL   Q RG SS + Y   +    GCRCVELDCWDG+  + EP+I HG  + S ILF DVI  I   AF  S YPV LS ENHCS  QQ  +A++ + +LG+ LLT P+      AG+P   LPSPE+L+ K+L+K KRLP
Sbjct:   58 FVVFYKLLTQ---RDELQALFSSLSGDGSVLSRGELAAFLRDFQREEGCEELRFAEELASS---ITERHELSNIARSLSVMTLDGFVRYLTSPDGS-LWDQRHDSIGHDMTRPLSHYFISSSHNTYLMEDQLRGPSSTEAYISSRAFRKGCRCVELDCWDGQ--NGEPVIYHGHTLTSKILFSDVIRTIEKYAFQVSDYPVILSIENHCSVAQQAVLARHMQSILGDKLLTAPL------AGLPSSQLPSPEQLRGKVLVKGKRLP 308

HSP 2 Score: 169.088 bits (427), Expect = 9.084e-44
Identity = 99/269 (36.80%), Postives = 145/269 (53.90%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSE-------KKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEE----TGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLS 2962
            LS+ V Y + V+F GF+ P ++   + +SSF+ET A   ++ D  E V +N  QLSR+YP G R DSSN+ PQ FWN GCQ+VALNFQ++   M L+ G F  N   GY+LKP F+     AF P +  P  G+      +K+ISGQ L +         I   V V+++G+P D  R E  T+ +  NG NP + E  +F    + +P++A+LR  V +         + Q  +    L+ G+RHI L S        SSLF  + ++
Sbjct:  361 LSNCVVYCRSVQFPGFSRPRDQASAWDISSFTETKARKLLREDGNEFVRHNTLQLSRVYPAGRRTDSSNYNPQEFWNVGCQIVALNFQTAGDEMDLHDGHFRQNGGCGYVLKPAFLCDPTTAFQPENPQPGIGLHTVRLTIKVISGQQLPKVPHSNKGSIIDPLVRVEVHGVPLDNARYE--TKYIDNNGFNPQWNEILSF---NINVPEVALLRFVVEDHDTATPNDFVAQYSIAFSSLRQGYRHIPLLSRDGTRVEPSSLFIHVKIA 624

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Sea Lamprey
Match: plcd3b (phospholipase C, delta 3b [Source:ZFIN;Acc:ZDB-GENE-081222-2])

HSP 1 Score: 189.119 bits (479), Expect = 1.236e-49
Identity = 110/261 (42.15%), Postives = 150/261 (57.47%), Query Frame = 2

Query:  890 EKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLD-LHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVP---LPSPEKLKYKILIKNKR 1660
            ++F  L   +  R D+  LF  LS     L   R+ +FL + Q +           + +    I+  +E     +S+G +++D F RYL S + + ++  R D +  DM QPL+HY+I+SSHNTYLT  Q RG SS + Y + L+ GCRCVELDCWDG   D EP+I HG  + S ILFRDVI +I   AF  S YPV LS ENHC+  QQ  +A++   +LGE L+T P+       G P   LPSPE+LK K LIK K+
Sbjct:  197 DEFVQLFRKLTRRDDVATLFKRLSPDGIGLPAARLAQFLQDEQHED---------DSEHRAACIIAEHEPLDEGRSKGLMTLDGFVRYLTSPDGS-LWDQRHDSVSHDMTQPLSHYFISSSHNTYLTDDQLRGPSSTEAYVKSLMRGCRCVELDCWDGA--DGEPVIYHGYTLTSQILFRDVITSIAHEAFKASAYPVILSLENHCNVEQQIVMARHLRSILGERLVTAPL------PGRPPTQLPSPEELKGKFLIKAKK 439

HSP 2 Score: 151.754 bits (382), Expect = 1.598e-37
Identity = 97/269 (36.06%), Postives = 138/269 (51.30%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKK-------IGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGV--FEETGK--LIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLS 2962
            LS  V Y   V F G       +    M SFSET  +G ++      V YN   LSR YP G RV S N+ P   WNAGCQ+VALNFQ+    M L  G F  N   GY+LKP F+R     FDP + +   G       + +ISGQ L +++       I   V V+++G+  DT  +E  T     NGLNP++ E+  F+F ++ +P+LA++R  V  ++ T +   IGQ  LP   L+ G+RH+ L S        ++LF  I ++
Sbjct:  491 LSDCVIYCSGVHFEGLERAESHQKGNEMCSFSETKTMGLIETQGNAFVRYNMQHLSRTYPSGTRVGSGNYNPHDMWNAGCQIVALNFQTPGKEMDLYDGLFRQNGGCGYVLKPSFLRDPHTDFDPGNPARGTGRHPVKLAITVISGQQLPKERNSRRGSIIDPLVSVEVHGVRGDTAVRE--THHQENNGLNPVWKEE--FLF-QLTVPELALIRFVVKDYDVTSRNDFIGQFSLPFSCLRQGYRHVHLLSLDGRSLFPATLFVHIRIT 754

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Yeast
Match: PLC1 (Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation [Source:SGD;Acc:S000006189])

HSP 1 Score: 125.176 bits (313), Expect = 2.857e-29
Identity = 68/161 (42.24%), Postives = 96/161 (59.63%), Query Frame = 2

Query: 1217 QPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGE--YLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLD 1693
            +PL HY+I SSHNTYL G+Q     SV+ Y QVL  GCRCVE+D WDG+     P++ HG  + S I  + VI  I+  AF+TSPYP+ +S E +C+K  Q   +    EVL E  Y +    +K        LPSP +LK+KIL+K+K+  + T  + ++
Sbjct:  384 KPLNHYFIASSHNTYLLGKQIAETPSVEGYIQVLQQGCRCVEIDIWDGENG---PVVCHG-FLTSAIPLKTVIRVIKKYAFITSPYPLIISLEINCNKDNQKLASLIMREVLAEQLYFVGTRTDK--------LPSPRELKHKILLKSKKTSEATRGLSVN 532

HSP 2 Score: 90.1225 bits (222), Expect = 1.995e-18
Identity = 79/283 (27.92%), Postives = 129/283 (45.58%), Query Frame = 2

Query: 2219 VKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELV--NYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNN-------SGYMLKPEFMR---RSERAFDPFSESPMDGVIAATCEVKIISGQFL--------SEKKIGTYVEVDMY--GLPTDTIRKEFRTRVVP---------ANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISL-RSEGNFPCALSSLFCKITLSTYV 2971
            +KF  F++P E +   H  S +E      +K+  ++L    +N+  L R+YP   R  SSNF P  FW AG QMVA N+Q++D+  QLN   F+  ++       SGY+LKP+ +       +      E   +G    T +++I+S Q L        S     ++V+V+ +    PT  I  +  TR+            NG NP++  + +   +     DL  ++  V  E  + I    L L+ L+ G+RHI L   EG        +FC + + T +
Sbjct:  596 IKFRNFSLP-ESKTIAHCFSLNERKVEYMIKDKHLKLSLDKHNRRYLMRVYPHVLRYKSSNFNPIPFWKAGVQMVATNWQTNDIGQQLNLAMFQILDHQPDGSFKSGYVLKPKKLLPVVTKAKMIPLIYEHFENGSDPVTVKIRILSTQLLPRLNDTSPSRNNTNSFVKVEFHTDDEPTMPISIDKGTRISATEASTKSSQGNGFNPIWDAEVSITLKDT---DLTFIKFMVISEETQ-IASVCLKLNYLRMGYRHIPLFNMEGE-----QYIFCTLFIHTQI 868

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Nematostella
Match: EDO42237 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S279])

HSP 1 Score: 400.208 bits (1027), Expect = 1.462e-117
Identity = 202/453 (44.59%), Postives = 281/453 (62.03%), Query Frame = 2

Query:  302 WRRNIPEELKKGALFDFYDDEL-------NILEVNCLVKVDEFGFFLSWKSEKS-EAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLK 1633
            W   +P +L+ G L   +D+         N L +N    VD+ GFFL+W+S+   E    ++  IS+V+ GV  KD+KV   LQ      +E+R   +  N++ V+ + L      S++   WV  LR + HN++  N   +TQL K +++  L  +   KI +K + K   +G+ E LV  +L+ L LPC K   + P  FTFE FY L   +CPR +I +L      G+   LT  +++ F+N+ QRDPRLNEIL+P+ +      ++  YE       +  I V+   RYL+S++N  +   RL+L  DM+QPL+HY+INSSHNTYL GRQF G+SSV+MYRQ L+AGCRC+ELDCWDG+ D  EPIITHG AMC+ ILF+DVI AIRD AF TS +PV LSFENHCSK QQYK+A YC ++LG+ L+TKP+E   LE G PLPSP +L+
Sbjct:    8 WEVYVPLKLQSGTLLSRWDEASFLNKEPNNKLRINT-TYVDKCGFFLAWRSQDDKEGSSIEISNISEVRLGVLPKDQKVRESLQRTGADPLEERGFTVVYNTNLVDCNYLHLFASTSRVAKEWVEGLRPLLHNVRLDNCSVLTQLHKQYVKAGLHKDALGKISVKSICKALYAGKFESLVLDALQALGLPCSKNDKITPEDFTFEHFYQLYLKVCPRLEIMELCVEWGGGRAPILTATQLVNFMNKEQRDPRLNEILFPFCDNEKALSLIWKYEKQMDMLQRDRICVNGLTRYLLSEDNLLIMPGRLNLSDDMNQPLSHYFINSSHNTYLVGRQFGGRSSVEMYRQCLIAGCRCIELDCWDGQND--EPIITHGNAMCTKILFKDVIEAIRDSAFQTSDFPVILSFENHCSKHQQYKMACYCMDILGDMLVTKPLESCPLEEGRPLPSPNQLR 457

HSP 2 Score: 387.497 bits (994), Expect = 3.719e-113
Identity = 218/615 (35.45%), Postives = 345/615 (56.10%), Query Frame = 2

Query: 2105 ESAEIEKDD-QTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFET---SEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHK------KKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLK-----------VLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRR 3886
            ++A +  DD   +  ++   S T N++P LSSLVNY QPV F GF+   ++   + MSSF+E+   G ++   ++ V YNK Q+SRIYPRG+RVDSSN++PQ+FWN GCQMV+LNFQ+ DL   LNQG+FE+N  SGY+LKP+ MRR +R FDPF+ESP+DG + A   +K+ISGQ+LS+KKI T VEVDMYGLPTDTIRK+++T+   +NGLN LY +  + VFR+V+LP++A+LR  V ++  ++I QRV+PLD +Q G+RH+ LR+E + P  L++LF  ITL  YVP+G+ + VD L++P       + +   M   G +    + +  + P     +K+ ++      + T                   IN  ++  K +   + + P              I+ E L + KT  K +KRQ KE   +QK+  KE   + ++H+   EKL +   + K    K      K+  +     +     +++  L++   ++  K+     +   ++      +    Y +            L Q    Q K   +  +RE  E+  +QTK S+EA + +  D   +NK ER+R+L++L  +N K+F+++R+
Sbjct:  537 DAASLTPDDVADIMASFPTQSTTGNINPLLSSLVNYIQPVPFQGFDESEKRNLFYQMSSFNESTGFGLVRATPLDFVKYNKRQMSRIYPRGSRVDSSNYMPQVFWNVGCQMVSLNFQTPDLPFHLNQGKFEFNGRSGYILKPDLMRRDDRMFDPFTESPIDGYVGAYVAIKVISGQYLSDKKITTVVEVDMYGLPTDTIRKKYKTKSSTSNGLNTLY-DGEHMVFRRVVLPEMALLRFAVIDDNDRIIAQRVVPLDSIQAGYRHVPLRTENDTPIPLATLFVHITLRCYVPEGYGAIVDELAEPIKFQCAADKRAAQMVVFGIDENVRARVIQVEPRLLQHSKEHSRSVGFSLKPT-------------------INEQLFIGKYKIVPIEFIP--------------ISLEELKKDKTYRKVIKRQQKESEVIQKKYSKERVMMQRAHTSELEKLITSYDEIKQAAQKTYERATKRCGDDRAKALKAVYDKKIAYLSQSQREKAQKVLATQTDEWTSMISRQIAEEIAIYEQHAETQICVLQAALDQAHEIQLKETVIKHERENSEIKKRQTKQSIEAGKSIFMDKTIKNKEERERKLKQLDRHNLKQFVEERQ 1117

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Nematostella
Match: EDO43813 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXP6])

HSP 1 Score: 377.867 bits (969), Expect = 2.052e-113
Identity = 176/298 (59.06%), Postives = 220/298 (73.83%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSE 3082
            LS LVNY QPV F  F++  ++   + MSSF ET A   +K   +E VNYNK QLSRIYP+G RV S N++PQIFWNAGCQ+VALNFQ+ DLAM LN G FEYN   GY+LKP FMRRS+R FDPF+ES +DG+IA    VK+ISGQ L+EKK+GTYVEV+MYGLP DT+RK++RT+VVP NG+NP+Y +D  F F+KV+LP LAVLRI V+EE+GKLIGQR+LP+DGL  G+RHI LR++ N P  L  LF  I    YVP GF  F +AL DP A  S+E+ + + +A +  E  E
Sbjct:  450 LSELVNYFQPVHFKSFDVSAKRNRSYEMSSFVETVATTQLKEKPVEFVNYNKRQLSRIYPKGTRVGSENYMPQIFWNAGCQLVALNFQTLDLAMMLNLGIFEYNGRCGYILKPSFMRRSDRTFDPFAESTVDGIIAGAVHVKVISGQLLTEKKVGTYVEVEMYGLPADTVRKKYRTKVVPNNGINPVY-DDDPFEFKKVVLPSLAVLRIAVYEESGKLIGQRILPVDGLNPGYRHIKLRNDCNLPLTLPVLFVHIITKDYVPSGFEDFANALCDPIAFQSQEDKRQQQLAALLDEEDE 746

HSP 2 Score: 365.54 bits (937), Expect = 4.495e-109
Identity = 176/393 (44.78%), Postives = 253/393 (64.38%), Query Frame = 2

Query:  494 KIKDEKVLSQLQDKTQSN-IEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNE--KLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKR 1660
            +++D+++   L   +  + + ++ + I   ++ V+L  + F+   S +   W  SL  + HN+   N CP T LKK + ++C+    + K+ +K V K  +S   E  K +  +L+ + LP  K   +   +F+F+ F+   N +C R DI  +F  + ++ K Y+  ++++ F+N  QRDPRLNEILYPY N    + I+  YE N     +G  SV    RYLMS++NAP+  DRL LHQDM QP++HY+INSSHNTYLTG Q  GKSSV+MYRQ LLAGCRC+ELDCWDGK +DQEP+ITHG  +C++I F+DVI AI +CAF TS YPV LSFENHC+  QQ K+A YC  + G+ LL+KP++ + LE G PLP  + L  KI+IKNK+
Sbjct:    1 RLQDQRLRDSLNIGSDEDPLTEKAITIVHGANMVDLMYVTFVSSSSTMARQWTDSLVKITHNLLEINECPTTFLKKQYTKICVQTTQDGKVSVKNVIKYISSSSKEDRKRIQDALQSVGLPHGKNDAISLEKFSFDIFWEFYNRLCNRQDIDKIFTEIGTKKKPYMVTEQLVDFINNNQRDPRLNEILYPYCNEEKAREIIRKYEPNQDFVKKGHFSVQGLTRYLMSEDNAPIHPDRLSLHQDMTQPISHYFINSSHNTYLTGHQLTGKSSVEMYRQTLLAGCRCIELDCWDGKTEDQEPVITHGMTLCTEISFKDVIEAIAECAFKTSDYPVILSFENHCTPKQQLKMASYCVNIFGDMLLSKPLDDYPLEEGRPLPPLKVLMRKIVIKNKK 393

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Nematostella
Match: EDO38229 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDH9])

HSP 1 Score: 201.445 bits (511), Expect = 5.588e-54
Identity = 123/325 (37.85%), Postives = 181/325 (55.69%), Query Frame = 2

Query: 2027 VIVKHKKYLHEKKSSA--KDLTSLMVGDESAEIEKDDQTVGMNYRHT-SGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKK--------IGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVF-EETGK--LIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITL 2959
            V++K KK   E++ +A  +D  ++   DE+A+IE++D         +      +   LS  VNY   V F  F    E    + MSSF E+      +N A   V YN  QLSR YP G+RVDSSN+ PQ+ WN GCQ+VALN+Q+    M LNQGRF  N  +GY+LKP +MR  +  F+P +     GV      +++ISGQ L + +        I  YVEV +YG+ +D+   +F+T+V+  NG NP++ E+   + + + +P+LA+LR  V+ E+ GK   IGQ  LP+  L+TG+RHI L      P   +SLF  + L
Sbjct:  346 VLIKGKKLKPEQEMAAVGEDDGTVSDEDEAADIEQEDLAAAREGEESKEKKVKLAKELSRCVNYISSVGFKNFEHSKENAKFYQMSSFVESKVATLAQNKAAGFVEYNTRQLSRTYPAGSRVDSSNYNPQVAWNVGCQIVALNYQTDGEYMHLNQGRFRENKRAGYVLKPAYMRNPDIKFNPNNPKSCPGVKKKLLIIQVISGQQLPKPQGSSSKGEVIDPYVEVKIYGVNSDS--ADFKTKVIKDNGFNPVWNEE---IKKLLYVPELAMLRFCVYDEDVGKDDFIGQFSLPITSLRTGYRHIHLLDIKGEPLPHASLFVHVML 665

HSP 2 Score: 191.815 bits (486), Expect = 8.402e-51
Identity = 131/398 (32.91%), Postives = 197/398 (49.50%), Query Frame = 2

Query:  602 TLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLV---NVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTD--LTQDLEIA--EDPDLIAGEDG 1774
            +L  + K  +  N W+  L+++ +N          Q K  WL         N + ++ L  V K   +  N  +  +++K+     E+      +    E+F      I  R +I ++ N  + GK ++  + + +FL +      + E+   Y +      I+ TYE     +   ++ +D    YL+S E          ++QDM QPL+HY+I SSHNTYL   Q +G SSVD Y      GCRCVELDCWD  GD+ +PI+ HG  + S I F+D+I A+ + AF  S YPV LS ENHC+   Q KIA++ E +LG+ L   P++     A   LPSPE LK K+LIK K+L  E E     M   G+ D  ++ + E A  E  DL A  +G
Sbjct:   25 SLDLVAKSVETANLWLVGLQTLINN----------QSKCTWLIDAFEKFDKNKDGELGLSEVTKLL-NALNVNITPKTIKKRFRVSEQAGA--EAALNKEEFAEFFKAIATRDEIVEIMNKFTSGKAHMNVEDLQKFLYKQG----VKEVSKQYCD-----IIISTYEPTEEGQRDKQLGIDGLTNYLLSKEGDIFDTAHDKVYQDMRQPLSHYFIASSHNTYLMEDQLKGPSSVDAYINAFNKGCRCVELDCWD--GDNGDPIVYHGHTLTSKIKFKDIIQAVAEHAFKVSDYPVILSLENHCNIENQRKIAEHLENILGDKLFKDPVDT----ALTSLPSPESLKGKVLIKGKKLKPEQE-----MAAVGEDDGTVSDEDEAADIEQEDLAAAREG 389

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Nematostella
Match: EDO28963 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T501])

HSP 1 Score: 187.193 bits (474), Expect = 3.067e-52
Identity = 112/275 (40.73%), Postives = 147/275 (53.45%), Query Frame = 2

Query:  854 KTADVD----PSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLP 1666
            K AD D         FE+F N    I  R ++  L       K+ +T   ++ FL   QR P  +E             I+ TYE     K    + +D F  YL+S +      +  D++QDM +PL+HY+I SSHNTYLTG Q    SS+DMY +VL +GCRC+ELDCWDGK  D EP++ HG  M S + FR VI  I D AF+ + YPV LS ENHCS  QQ  +A +  +   + L    I    L  G  LPSP++L  KILIK K+LP
Sbjct:   43 KAADTDTVNSSGLLDFEEFANFYKSISTRRELYMLLLKYGNSKENMTVQELLNFLRIEQRVPECDE--------EYCSNIIQTYEPADSNKKNMLLGIDGFTSYLLSADGEIFNPEHSDVYQDMTRPLSHYFIASSHNTYLTGDQLASASSMDMYVRVLQSGCRCLELDCWDGK--DGEPVVYHGYTMTSKVKFRYVILNINDFAFLNNRYPVILSLENHCSVEQQKFMANFMRDTFKDILC---ILFFMLFDGKDLPSPQELMGKILIKTKKLP 304

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Nematostella
Match: EDO31556 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXK4])

HSP 1 Score: 188.348 bits (477), Expect = 2.010e-50
Identity = 98/251 (39.04%), Postives = 153/251 (60.96%), Query Frame = 2

Query:  905 LLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNK 1657
            +   I  R ++  LF ++S    ++T D +  F+ + QR        +  +++ + + ++  +E++   K+Q ++ +D F  ++ S   +        ++QDM+QPL+HY+I SSHNTYL G Q +G SSV  YR VL  GCRCVELDCWD  GDD+EPI+ HG  + S +LF+D++ AI++ AF  SPYPV +S ENHCS   Q K+A++ + +LG  L T P++   L+A   LPSP+    KIL++ K
Sbjct:    1 MYKFISKRKEVDLLFRNVSSNGAWVTVDDLEDFMTKDQR--------FDVTHK-TCKELIKKFEVSQRGKAQLQLGIDGFLSFINSQHASLFNPAHEKIYQDMNQPLSHYFIASSHNTYLLGHQLKGSSSVQAYRDVLERGCRCVELDCWD--GDDEEPIVYHGHTLTSKVLFKDIVQAIKESAFKVSPYPVIVSLENHCSVQFQIKMAEHLKGILGSLLYTTPVD-FTLDA---LPSPKFFLNKILVRGK 236

HSP 2 Score: 156.762 bits (395), Expect = 6.508e-40
Identity = 104/304 (34.21%), Postives = 157/304 (51.64%), Query Frame = 2

Query: 2102 DESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDG-------------VIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVI-LPDLAVLRIGVFEET---GKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLS 2962
            D   +IE+  Q    ++R T    +V   LS L+NY    KF  F    E        SF E+  L  +   A E V +NK+Q+SRIYP   RVDSSN+ P   W  GCQ+VALN Q++   MQL+ G+F  N N+GY+LKP+F+R  E  FDP    P DG             VI+A   ++I     L   +   YV+V+++G+P D  +  F T  +    LNP++ E+    F+ ++ +P+LA+++  V++E       +GQ V+P + L  G+R I L      P   ++LF  + +S
Sbjct:  255 DRKVQIERSVQET--DFRGTK--EHVADELSQLINYISNEKFKSFIESMEMGHFSQTHSFVESEMLYFLDKSASEFVEFNKHQISRIYPGNLRVDSSNYDPIKPWTVGCQIVALNHQTNSEEMQLHYGKFRQNGNTGYVLKPKFLRDPELTFDP---DPQDGKFPGIQPKRLQLTVISAFQLLEIEESWSLVRDEPDPYVQVEVHGVPAD--KATFTTHGLTDTTLNPVWNEE----FQTIVHVPELAMVQFVVYDEDYGFDDFLGQVVIPFESLMEGYRQIQLLDMSGLPLPGTTLFVHVKIS 545

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Medaka
Match: PLCB4 (phospholipase C beta 4 [Source:NCBI gene;Acc:100049535])

HSP 1 Score: 1143.26 bits (2956), Expect = 0.000e+0
Identity = 594/1236 (48.06%), Postives = 815/1236 (65.94%), Query Frame = 2

Query:  281 SKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQD--KTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGK-DYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAE--DPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGD--ESAEIEKD-DQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMH------------------KKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            +K YEF W++++PE +++GA FD +D++  + E NCLV+VDEFGFF++WK+E  E  V +  LI+ ++ G   KD K+LS  +   KT++++E   + I   +D VNL  +  +  + +    W+  LRSV HN KA N+CPMT LKKHW+++C L N+N KIP++ + +TFASG+ EK +FQ+LK+L LP  K  +++PS FTF+ FY L   ICPRTDI++LF  ++  K DYLT D ++ FLNE QRDPRLNEIL+P+ +      I++ YE +   K +G +S D F RYLMSDENAPVFLDRL+L+Q+MDQPLAHY+I+SSHNTYLTGRQF GKSSV+MYRQVLL+GCRCVELDCWDGKG+DQEPIITHGKAMC+DILF+DVI AI++ AFVTS YPV LSFENHCSKPQQYK+AKYCEE+ G+ LL +P+E H +E G PLPSP  LK KILIKNKRL  E E+ Q + F K        +E  E   P +I GE+  +                                +      +S  P+     +++ EAN   LK+  +    + K E SN+   V  +H      + + A D++     D  ++ E+ +D ++ +   Y +   TTN+HP+LS++VNYAQPVKF  F++  E+   ++MSSF+E+  LG++K +AIE VNYNK Q+SRIYP+G RVDSSN++PQIFWNAGCQMV+LNFQ+ DLAMQLNQG+FEYN + GY+LKP+FMRRS+R FDPFSE+P+DGVIAATC V++ SGQFLS+KKIGTYVEVDMYGLPTDTIRKEFRTR+V  NGLNP Y E+  FVFRKVILPDLAVLRI V+++  KLIGQR+LPLDGLQ G+RHISLR+EGN P +L ++FC+I L TYVPDGF + VDALSDP+  ++  E +   M  +G +T++I D+ PS +S      K +   +   D   +         S T + +S++ Q     +N     N S+  KD  +    + E L +TK  +K +K+Q KE + L+K+  KE N + K+H    +K+ S   K+KS +                   KK+TE++++  + +   + +  +T ++ +E ++L   H N EQ +K  +  Q  E   K+L+  Q  Q   L+L+ +R+ KEM   Q K SME ++ +  D   +NKAER+RR+REL   N K+FLD+R+   MKH +
Sbjct:    2 TKCYEFNWQKHLPEFMQEGASFDRFDEDPYLFEPNCLVRVDEFGFFITWKNEGKEGQVLECSLINSIRVGAVPKDPKILSSFESIGKTEADLEGCIICICSGADLVNLSFMFMVADNPETARKWIEGLRSVIHNFKANNVCPMTCLKKHWMKMCFLTNINGKIPVRGITRTFASGKTEKGIFQALKDLGLPSGKNDEIEPSDFTFDMFYALTQKICPRTDIEELFKKINGNKTDYLTVDHLVSFLNENQRDPRLNEILFPFYDPKRAMQIIEKYERDEELKKKGRMSSDGFCRYLMSDENAPVFLDRLELYQEMDQPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLSGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSDYPVILSFENHCSKPQQYKMAKYCEEIFGDLLLKQPLESHPIEPGRPLPSPNDLKRKILIKNKRLKPEVEQKQFEAFKK-------HMEAGETNTPAIIMGEEDDVENGE---------------------------KEGEEKDLNSEAPSCLSEMTSVKEANDVSLKETVS----LKKEEQSNSIKKV-PEHDGTEMSEATDATDISEASDQDNKKAGEVAEDSEEALIAQYTYEGATTNIHPFLSAMVNYAQPVKFQSFDVAEERNIHYNMSSFNESVGLGYLKTNAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNFQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRSDRMFDPFSETPVDGVIAATCSVQVFSGQFLSDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPAYNEEP-FVFRKVILPDLAVLRIAVYDDNNKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTVFCQIILKTYVPDGFGAIVDALSDPKKFLTIAEKRADQMKALGIDTNDIADV-PSGNS------KNDKKGKGKGDTVKT---------SVTPQASSDMAQTSNSAQN-----NTSESKKDATLVPNASIEDLKQTKAYLKLMKKQQKELNALKKKHSKEQNTMQKAHCTQVDKMVSLHEKEKSTLEKLLEKAFKKRGENNCQELKKETEDKIQTLVTEHKAK-VKEITAQHTKEWSELISGHSNKEQEMKDGHVMQQCEVLKKLLNNNQEQQTSQLKLIHERQSKEMRANQAKVSMENSKAINQDKTIKNKAERERRVRELNSSNTKKFLDERKRLAMKHQK 1175

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Medaka
Match: PLCB1 (phospholipase C beta 1 [Source:NCBI gene;Acc:101172698])

HSP 1 Score: 361.688 bits (927), Expect = 2.065e-103
Identity = 189/451 (41.91%), Postives = 278/451 (61.64%), Query Frame = 2

Query:  314 IPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSG--VKIKDEKVLSQLQDKTQ--SNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKP-QQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILI 1648
            +PE LKKG  F  ++D+   +    L  VD  G+FL W  +  +  + D+  I D ++G   K+  +  L ++ D +     +E+R L +   +D VN+  L F+    +I   W   L  +  N+   N    T L+K + RL L +N   +IP+K + + F++ R  K V  +L+  NLP  +   +    FT E +   L+ ICPR ++  +F+ + ++ + YLT ++M  F+N  QRDPRLNEILYP      VQ ++D YE N     +G++SV+ F RYL  +EN+ +  ++LD  +DM  PL+HY+INSSHNTYLT  Q  G SSV+MY+QVLL+GCRC+ELDCW G+  ++EP+ITHG  M ++I F++VI AI +CAF TSP+P+ LSFENH   P QQ K+A+YC  + G+ LL +P+EK+QLEAGVPLPSP +L  KILI
Sbjct:   18 VPECLKKGNKFMKWEDDSTAVTPVTLT-VDPKGYFLYWTDQNKDTDLLDVAFIKDARNGKFCKMPKDAKLREVLDISTLVGKLENRMLTVVSGTDMVNITYLNFMAFQEEIAKEWAEELFKLASNLLVQNSSRETCLEKVYTRLKLQLNPEGRIPVKNIFRIFSADR--KRVETALESCNLPSGRNESIPQEDFTPEVYSMFLSNICPRPELDHIFSEIGAKSRPYLTVEQMTEFINSKQRDPRLNEILYPPLKAEQVQVLVDKYEPNASLAQKGQMSVEGFSRYLNGEENSIIPPEKLDQSEDMTFPLSHYFINSSHNTYLTAGQLAGNSSVEMYKQVLLSGCRCIELDCWKGRTTEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPIILSFENHVDSPKQQAKMAEYCRSIFGDALLMEPLEKYQLEAGVPLPSPMELMGKILI 465

HSP 2 Score: 345.125 bits (884), Expect = 6.354e-98
Identity = 183/439 (41.69%), Postives = 267/439 (60.82%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAI--FEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHK 3499
            +S+LV Y QPVKF  F    +    + MSSF ET AL  +    +E V YNK QLSRIYP+G RVDSSN+ PQ+FWNAGCQ+VALNFQ+ DL+MQLN G FEYN   GY LKPEFMRR ++ FDPF+ES +DG++A T  VKI+SGQFLS+KK+GTYVE+DM+GLP DT RK F+T+    N +NP++ E++  VF+KV+LP LA LRI VFEE GK IG R+ P   ++ G+ +I+LR+E N    L SLF  + +  YVPD FA  ++ALS+P  +++  E +   +A +  E    ++      + +   T+ ++ R     G     + G+      +K  S V     ++   +    K++D     +   E  T E L + K+ V+  ++Q KE   L ++  ++  E++K H+    +L+    +++S + K
Sbjct:  569 MSNLVLYIQPVKFHSFETSKKINRSYQMSSFVETKALEQLTKCPVEFVEYNKLQLSRIYPKGTRVDSSNYNPQLFWNAGCQLVALNFQTVDLSMQLNLGMFEYNGKCGYRLKPEFMRRPDKHFDPFTESTVDGIVANTLSVKILSGQFLSDKKVGTYVEIDMFGLPVDTKRKAFKTKTSQGNAINPVWEEEA-IVFKKVVLPTLASLRIAVFEEGGKFIGHRIFPASAIRPGYHYINLRNEKNQLLTLPSLFVYVEVKDYVPDTFADVIEALSNPIRYVNLMEQRANQLAALTLEEGGEEEGDKEVEAGSDAPTESKVDR-----GVVQPAENGLETPIIPSKPPSLVG--PTQSAGSLKPAAKTEDIIQSVLTELEAHTVEELKQQKSFVREQRKQYKEMKELVRKHHRKTGEMIKEHTARISELQGQHQRRRSALQK 999

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Medaka
Match: PLCB1 (phospholipase C beta 1 [Source:NCBI gene;Acc:101172698])

HSP 1 Score: 361.688 bits (927), Expect = 3.391e-103
Identity = 189/451 (41.91%), Postives = 278/451 (61.64%), Query Frame = 2

Query:  314 IPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSG--VKIKDEKVLSQLQDKTQ--SNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKP-QQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILI 1648
            +PE LKKG  F  ++D+   +    L  VD  G+FL W  +  +  + D+  I D ++G   K+  +  L ++ D +     +E+R L +   +D VN+  L F+    +I   W   L  +  N+   N    T L+K + RL L +N   +IP+K + + F++ R  K V  +L+  NLP  +   +    FT E +   L+ ICPR ++  +F+ + ++ + YLT ++M  F+N  QRDPRLNEILYP      VQ ++D YE N     +G++SV+ F RYL  +EN+ +  ++LD  +DM  PL+HY+INSSHNTYLT  Q  G SSV+MY+QVLL+GCRC+ELDCW G+  ++EP+ITHG  M ++I F++VI AI +CAF TSP+P+ LSFENH   P QQ K+A+YC  + G+ LL +P+EK+QLEAGVPLPSP +L  KILI
Sbjct:   18 VPECLKKGNKFMKWEDDSTAVTPVTLT-VDPKGYFLYWTDQNKDTDLLDVAFIKDARNGKFCKMPKDAKLREVLDISTLVGKLENRMLTVVSGTDMVNITYLNFMAFQEEIAKEWAEELFKLASNLLVQNSSRETCLEKVYTRLKLQLNPEGRIPVKNIFRIFSADR--KRVETALESCNLPSGRNESIPQEDFTPEVYSMFLSNICPRPELDHIFSEIGAKSRPYLTVEQMTEFINSKQRDPRLNEILYPPLKAEQVQVLVDKYEPNASLAQKGQMSVEGFSRYLNGEENSIIPPEKLDQSEDMTFPLSHYFINSSHNTYLTAGQLAGNSSVEMYKQVLLSGCRCIELDCWKGRTTEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPIILSFENHVDSPKQQAKMAEYCRSIFGDALLMEPLEKYQLEAGVPLPSPMELMGKILI 465

HSP 2 Score: 345.51 bits (885), Expect = 1.062e-97
Identity = 183/439 (41.69%), Postives = 267/439 (60.82%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAI--FEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHK 3499
            +S+LV Y QPVKF  F    +    + MSSF ET AL  +    +E V YNK QLSRIYP+G RVDSSN+ PQ+FWNAGCQ+VALNFQ+ DL+MQLN G FEYN   GY LKPEFMRR ++ FDPF+ES +DG++A T  VKI+SGQFLS+KK+GTYVE+DM+GLP DT RK F+T+    N +NP++ E++  VF+KV+LP LA LRI VFEE GK IG R+ P   ++ G+ +I+LR+E N    L SLF  + +  YVPD FA  ++ALS+P  +++  E +   +A +  E    ++      + +   T+ ++ R     G     + G+      +K  S V     ++   +    K++D     +   E  T E L + K+ V+  ++Q KE   L ++  ++  E++K H+    +L+    +++S + K
Sbjct:  569 MSNLVLYIQPVKFHSFETSKKINRSYQMSSFVETKALEQLTKCPVEFVEYNKLQLSRIYPKGTRVDSSNYNPQLFWNAGCQLVALNFQTVDLSMQLNLGMFEYNGKCGYRLKPEFMRRPDKHFDPFTESTVDGIVANTLSVKILSGQFLSDKKVGTYVEIDMFGLPVDTKRKAFKTKTSQGNAINPVWEEEA-IVFKKVVLPTLASLRIAVFEEGGKFIGHRIFPASAIRPGYHYINLRNEKNQLLTLPSLFVYVEVKDYVPDTFADVIEALSNPIRYVNLMEQRANQLAALTLEEGGEEEGDKEVEAGSDAPTESKVDR-----GVVQPAENGLETPIIPSKPPSLVG--PTQSAGSLKPAAKTEDIIQSVLTELEAHTVEELKQQKSFVREQRKQYKEMKELVRKHHRKTGEMIKEHTARISELQGQHQRRRSALQK 999

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Medaka
Match: PLCB1 (phospholipase C beta 1 [Source:NCBI gene;Acc:101172698])

HSP 1 Score: 360.918 bits (925), Expect = 5.729e-103
Identity = 189/451 (41.91%), Postives = 278/451 (61.64%), Query Frame = 2

Query:  314 IPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSG--VKIKDEKVLSQLQDKTQ--SNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSL-SEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKP-QQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILI 1648
            +PE LKKG  F  ++D+   +    L  VD  G+FL W  +  +  + D+  I D ++G   K+  +  L ++ D +     +E+R L +   +D VN+  L F+    +I   W   L  +  N+   N    T L+K + RL L +N   +IP+K + + F++ R  K V  +L+  NLP  +   +    FT E +   L+ ICPR ++  +F+ + ++ + YLT ++M  F+N  QRDPRLNEILYP      VQ ++D YE N     +G++SV+ F RYL  +EN+ +  ++LD  +DM  PL+HY+INSSHNTYLT  Q  G SSV+MY+QVLL+GCRC+ELDCW G+  ++EP+ITHG  M ++I F++VI AI +CAF TSP+P+ LSFENH   P QQ K+A+YC  + G+ LL +P+EK+QLEAGVPLPSP +L  KILI
Sbjct:   18 VPECLKKGNKFMKWEDDSTAVTPVTLT-VDPKGYFLYWTDQNKDTDLLDVAFIKDARNGKFCKMPKDAKLREVLDISTLVGKLENRMLTVVSGTDMVNITYLNFMAFQEEIAKEWAEELFKLASNLLVQNSSRETCLEKVYTRLKLQLNPEGRIPVKNIFRIFSADR--KRVETALESCNLPSGRNESIPQEDFTPEVYSMFLSNICPRPELDHIFSEIGAKSRPYLTVEQMTEFINSKQRDPRLNEILYPPLKAEQVQVLVDKYEPNASLAQKGQMSVEGFSRYLNGEENSIIPPEKLDQSEDMTFPLSHYFINSSHNTYLTAGQLAGNSSVEMYKQVLLSGCRCIELDCWKGRTTEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPIILSFENHVDSPKQQAKMAEYCRSIFGDALLMEPLEKYQLEAGVPLPSPMELMGKILI 465

HSP 2 Score: 337.421 bits (864), Expect = 3.257e-95
Identity = 157/292 (53.77%), Postives = 207/292 (70.89%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANM 3064
            +S+LV Y QPVKF  F    +    + MSSF ET AL  +    +E V YNK QLSRIYP+G RVDSSN+ PQ+FWNAGCQ+VALNFQ+ DL+MQLN G FEYN   GY LKPEFMRR ++ FDPF+ES +DG++A T  VKI+SGQFLS+KK+GTYVE+DM+GLP DT RK F+T+    N +NP++ E++  VF+KV+LP LA LRI VFEE GK IG R+ P   ++ G+ +I+LR+E N    L SLF  + +  YVPD FA  ++ALS+P  +++  E +   +A +
Sbjct:  563 MSNLVLYIQPVKFHSFETSKKINRSYQMSSFVETKALEQLTKCPVEFVEYNKLQLSRIYPKGTRVDSSNYNPQLFWNAGCQLVALNFQTVDLSMQLNLGMFEYNGKCGYRLKPEFMRRPDKHFDPFTESTVDGIVANTLSVKILSGQFLSDKKVGTYVEIDMFGLPVDTKRKAFKTKTSQGNAINPVWEEEA-IVFKKVVLPTLASLRIAVFEEGGKFIGHRIFPASAIRPGYHYINLRNEKNQLLTLPSLFVYVEVKDYVPDTFADVIEALSNPIRYVNLMEQRANQLAAL 853

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Medaka
Match: ENSORLT00000042446.1 (1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [Source:NCBI gene;Acc:101175365])

HSP 1 Score: 347.436 bits (890), Expect = 7.469e-99
Identity = 188/431 (43.62%), Postives = 265/431 (61.48%), Query Frame = 2

Query: 2189 LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVP-ANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANM----GFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTK--------INSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITP---ESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLK 3433
            +S+LVNY QP KF  F    +   C+HMSSF ET AL H+    +E V YNK QLSRIYP+G RVDSSNF+PQ+FWNAGCQ+VALN+Q+ DL+MQLN   FEYN  SGY LKPEFMRR ++ FDPF+E+ +DG++A T  VK+ISGQFL+E+++G YVEV+M+GLP DT RK  +T+     N +NP++ E+   VF+KVILP LA LRI  FEE GK IG  ++P+  ++ G+R+I LR+E N    L ++F  I +  YVPD FA  ++ALS+P  +++  E + K +A +    G E ++ +D + ST+   K+   K          T S  + G    ++T K          ++  +  V+ E+LV S           +  E+ P   E L ++K   K  +RQ KE   L +R  K+ +ELL+
Sbjct:  532 MSTLVNYVQPTKFNSFEASKKAARCYHMSSFVETKALEHLTKSPVEFVEYNKSQLSRIYPKGTRVDSSNFMPQLFWNAGCQLVALNYQTIDLSMQLNLFMFEYNGRSGYRLKPEFMRRPDKHFDPFTENTVDGIVANTLSVKVISGQFLTERRVGVYVEVEMFGLPADTRRKALKTKTSQNNNAINPVWDEEP-IVFKKVILPTLASLRIAAFEEGGKFIGHHIIPVSAIRPGYRYIGLRNERNQSLMLPAVFVYIEVKDYVPDTFADVIEALSNPIRYVNLLEQRSKQLAALTLEDGEEEAQTEDEADSTT--EKRADLKPATVENGLSPTSS--QAGHTPAATTPKASSANQQAAAADPAKASVKTEDLVLS-----------VLIEVPPCLLEHLQQSKLYSKEQRRQFKELKELSRRHQKKTSELLR 946

HSP 2 Score: 333.954 bits (855), Expect = 2.546e-94
Identity = 183/455 (40.22%), Postives = 270/455 (59.34%), Query Frame = 2

Query:  311 NIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSG--VKIKDEKVLSQLQDKTQ--SNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHC-SKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKR 1660
            ++   L+ G+ F  +D++L+ +     + VD  GF+L W  +  +  + D+ ++ DV++G   K   E  L +L D       +E+R + +   SD VN++ L FI         W   L S+  N+ + N+     L K ++RL L +N + +IP+K + + F+S R  K V  +L    LP  +   +    FT E + + L+ +CPR ++ ++F         L+ D+M  F+N  QRDPRLNEILYP         +++ ++L+     +G IS+  F  YL SDEN  +  ++LD  +DM  P++HY+INSSHNTYLT  Q  G SSV+MYRQVLLAGCRCVELD W G+  ++EP+ITHG  M S+I F++VI AI +CAF TS +PV LSFENH  S  QQ K+A+YC  + G+ LL  P++K+ LEAGV LPSP +L  KILIKNK+
Sbjct:   17 SVSHTLRNGSNFIKWDEDLSTV-TPVTLHVDPNGFYLYWTDQNKDTELLDLTVVKDVRTGRSTKTTKEAKLRELLDVGNLVGRLENRMVTVVTASDLVNVNQLNFIASQEDEAKVWCEELFSLSSNLLSHNLNRDQSLLKAYVRLTLQLNTDGRIPVKNIVRLFSSDR--KRVETALDSCRLPYGRGDSIRVEDFTLEVYKSFLDSLCPRPELGNIFKLQGGNGGMLSIDQMTEFINNKQRDPRLNEILYPPFRPAQTLSLMERHQLDQAELKRGLISLQAFSMYLSSDENGVIPPEKLDQSEDMSFPMSHYFINSSHNTYLTAGQLAGSSSVEMYRQVLLAGCRCVELDVWKGRTAEEEPVITHGFTMTSEISFKEVIEAIAECAFKTSLFPVILSFENHVDSLKQQAKMAEYCRSIFGDALLIDPLDKYPLEAGVALPSPLELMGKILIKNKK 468

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Planmine SMEST
Match: SMESG000024212.1 (SMESG000024212.1)

HSP 1 Score: 2379.36 bits (6165), Expect = 0.000e+0
Identity = 1209/1246 (97.03%), Postives = 1213/1246 (97.35%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNRXXXXXXXXXXXXXXXXFEFIEE 3976
            MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSEDDDDDDDDAEAEAEINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANG +          F +++L                     VLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHLNAEQNLKLLNQQQLKEAYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNRQVELLEQKHEEQKKRLFEFIEE
Sbjct:    1 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEIAEDPDLIAGEDGALNVVSSEDDDDDDDDAEAEAEINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGKS----------FYQILL---------------------VLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHLNAEQNLKLLNQQQLKEAYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNRQVELLEQKHEEQKKRLFEFIEE 1215

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Planmine SMEST
Match: SMESG000049234.1 (SMESG000049234.1)

HSP 1 Score: 1336.63 bits (3458), Expect = 0.000e+0
Identity = 671/1228 (54.64%), Postives = 878/1228 (71.50%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDL-EIAEDPD---LIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            MTSDIAKRQRTVPSSK +EF WR+ + ++L  GA FD YD++ N LE NCLV+VDE+GFF+ WKSE+ E  V D+  +SDV+ G K K++K+ + L ++  + ++DR + I   +D VN+     + +D++I  FW+ +LR + HN K  N+CPM QLKKHWLRLCL V  N  IP++ ++KTFASG+ EK++FQSLKEL LP  K  ++DPS FTFEKFY L + ICPRTDI+++F  LS  KD++T +++I +LNE QRDPRLNEIL+P++N+++V+YILD  E +   + +G++S++CFYRYLMSD+NAPVFLDRL++ QDMDQPLAHYYINSSHNTYLTGRQF GKSSV++YRQVLL+GCRC+ELDCWDGKG+DQEPIITHGKAMC+DILF+DVIYAIRD AFVTS  P+ LSFENHCSKPQQYK+AKYCE+VLG+ LLTKPI+KH+L   VPLPSP KL+ KILIKNKRL  E EK QL+MFLKGQT++ Q+  E AEDPD   ++ GEDG +N +                                         N  II  N  + +  + K E N    +   E S+ +  + VK +K    +K+++K       G  +AE   ++Q +   Y +   TTN+HPYLS++VNY QPVKF GF+I  E+   FHMSSFSET ALG++KN+AIE VNYNK QLSRIYPRGNRVDS+NF+PQIFWNAGCQMVALNFQ+ DLAMQLNQG+FEYN NSGY+LKPEFMRR ER+FDPFSESPMDGVIAAT E+KIISGQFLS+KK+GTYVEVDMYGLPTDT RKEFRTRVVP NGLNP+Y +DS F+FRKV+LPDLAVLRIGV+E+TGKLIGQRVLPL+GLQ+G+RHISLR+EGNFP +L ++FCKIT +TY+P+G    VDALSDPRA++S+EE ++K +A+MG ETS+I D+   T+    K+   +     + +    N+     Q +++T          V    + +S NK  D KD+  F+ I+   L   KT  K +KRQ +E  NL+K+  K+   L KS ++ T+KL +   ++ +   K K EN+    + +    +M+ L + +  E   +   H   E +L +   +  +E  LKV+ ++Q  Q+K L+++Q+RE+KEM  QQTK+S++AN+ VI D   +NKAERDRR+REL D N KRF+DQR+AQ  K +R
Sbjct:    1 MTSDIAKRQRTVPSSKAFEFNWRQPVSDDLINGAHFDRYDEDSNSLESNCLVRVDEYGFFVHWKSEQGEGQVLDLSQVSDVRFGSKPKEDKICAVLLERISNPLDDRIVTICSGTDLVNISYTHMVSQDNEIATFWINNLRPLTHNTKMNNVCPMIQLKKHWLRLCLGVKANGMIPVRSISKTFASGKTEKIIFQSLKELGLPFGKNDEIDPSSFTFEKFYELYHKICPRTDIEEIFKELSNSKDFITTEKIIEYLNEVQRDPRLNEILFPFANKDTVKYILDNNEPSEEYRKEGKLSIECFYRYLMSDDNAPVFLDRLNICQDMDQPLAHYYINSSHNTYLTGRQFGGKSSVEIYRQVLLSGCRCIELDCWDGKGEDQEPIITHGKAMCTDILFKDVIYAIRDTAFVTSEMPIILSFENHCSKPQQYKLAKYCEDVLGDLLLTKPIDKHELSQAVPLPSPLKLRKKILIKNKRLKPEVEKQQLEMFLKGQTEIIQEENENAEDPDPLVMVDGEDGPMNEI-----------------------------------------NPTIIVKNDTDPHPEMHKTELNGLLKVK--EQSDTQLNIKVKEEKEPDSRKNASKK------GSLTAE---EEQAMLAQYHYIGATTNIHPYLSAMVNYTQPVKFQGFDIAEEEAYHFHMSSFSETVALGYLKNEAIEFVNYNKRQLSRIYPRGNRVDSANFMPQIFWNAGCQMVALNFQTPDLAMQLNQGKFEYNGNSGYLLKPEFMRRPERSFDPFSESPMDGVIAATLEIKIISGQFLSDKKVGTYVEVDMYGLPTDTFRKEFRTRVVPNNGLNPIYGDDSVFLFRKVVLPDLAVLRIGVYEDTGKLIGQRVLPLEGLQSGYRHISLRTEGNFPLSLPTIFCKITQTTYIPEGLVDLVDALSDPRAYLSKEEKRMKQLADMGIETSDIVDV--PTTGKPFKKPPDKKSENSNQEPLTPNLANKSGQSNNST----------VSTPVVGFSNNKKDDKKDEPKFDNISLVLLETDKTFQKLIKRQTRELENLRKKHEKDSAILHKSQTIVTDKLNANHAREINKKVKVKGENEESDMIEEVQKNQMVDLVKTHTDEWTSMKLQHRKEEHDLCMSFLESRQELLLKVMKEVQEDQKKELKIIQEREIKEMKAQQTKASIDANKNVINDRKLKNKAERDRRIRELNDINTKRFIDQRKAQAQKQDR 1164

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Planmine SMEST
Match: SMESG000049234.1 (SMESG000049234.1)

HSP 1 Score: 1320.45 bits (3416), Expect = 0.000e+0
Identity = 663/1228 (53.99%), Postives = 872/1228 (71.01%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDL-EIAEDPD---LIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            MTSDIAKRQRTVPSSK +EF WR+ + ++L  GA FD YD++ N LE NCLV+VDE+GFF+ WKSE+ E  V D+  +SDV+ G K K++K+ + L ++  + ++DR + I   +D VN+     + +D++I  FW+ +LR + HN K  N+CPM QLKKHWLRLCL V  N  IP++ ++KTFASG+ EK++FQSLKEL LP  K  ++DPS FTFEKFY L + ICPRTDI+++F  LS  KD++T +++I +LNE QRDPRLNEIL+P++N+++V+YILD  E +   + +G++S++CFYRYLMSD+NAPVFLDRL++ QDMDQPLAHYYINSSHNTYLTGRQF GKSSV++YRQVLL+GCRC+ELDCWDGKG+DQEPIITHGKAMC+DILF+DVIYAIRD AFVTS  P+ LSFENHCSKPQQYK+AKYCE+VLG+ LLTKPI+KH+L   VPLPSP KL+ KILIKNKRL  E EK QL+MFLKGQT++ Q+  E AEDPD   ++ GEDG +N +                                         N  II  N  + +  + K E N    +   E S+ +  + VK +K    +K+++K       G  +AE   ++Q +   Y +   TTN+HPYLS++VNY QPVKF GF+I  +    +HMSSF+E   LG ++ D I LV+YNK QLSRIYPRGNRVDS+NF+PQIFWNAGCQMVALNFQ+ DLAMQLNQG+FEYN NSGY+LKPEFMRR ER+FDPFSESPMDGVIAAT E+KIISGQFLS+KK+GTYVEVDMYGLPTDT RKEFRTRVVP NGLNP+Y +DS F+FRKV+LPDLAVLRIGV+E+TGKLIGQRVLPL+GLQ+G+RHISLR+EGNFP +L ++FCKIT +TY+P+G    VDALSDPRA++S+EE ++K +A+MG ETS+I D+   T+    K+   +     + +    N+     Q +++T          V    + +S NK  D KD+  F+ I+   L   KT  K +KRQ +E  NL+K+  K+   L KS ++ T+KL +   ++ +   K K EN+    + +    +M+ L + +  E   +   H   E +L +   +  +E  LKV+ ++Q  Q+K L+++Q+RE+KEM  QQTK+S++AN+ VI D   +NKAERDRR+REL D N KRF+DQR+AQ  K +R
Sbjct:    1 MTSDIAKRQRTVPSSKAFEFNWRQPVSDDLINGAHFDRYDEDSNSLESNCLVRVDEYGFFVHWKSEQGEGQVLDLSQVSDVRFGSKPKEDKICAVLLERISNPLDDRIVTICSGTDLVNISYTHMVSQDNEIATFWINNLRPLTHNTKMNNVCPMIQLKKHWLRLCLGVKANGMIPVRSISKTFASGKTEKIIFQSLKELGLPFGKNDEIDPSSFTFEKFYELYHKICPRTDIEEIFKELSNSKDFITTEKIIEYLNEVQRDPRLNEILFPFANKDTVKYILDNNEPSEEYRKEGKLSIECFYRYLMSDDNAPVFLDRLNICQDMDQPLAHYYINSSHNTYLTGRQFGGKSSVEIYRQVLLSGCRCIELDCWDGKGEDQEPIITHGKAMCTDILFKDVIYAIRDTAFVTSEMPIILSFENHCSKPQQYKLAKYCEDVLGDLLLTKPIDKHELSQAVPLPSPLKLRKKILIKNKRLKPEVEKQQLEMFLKGQTEIIQEENENAEDPDPLVMVDGEDGPMNEI-----------------------------------------NPTIIVKNDTDPHPEMHKTELNGLLKVK--EQSDTQLNIKVKEEKEPDSRKNASKK------GSLTAE---EEQAMLAQYHYIGATTNIHPYLSAMVNYTQPVKFQGFDIAEDLNIHYHMSSFNENVGLGLIRRDCIALVDYNKRQLSRIYPRGNRVDSANFMPQIFWNAGCQMVALNFQTPDLAMQLNQGKFEYNGNSGYLLKPEFMRRPERSFDPFSESPMDGVIAATLEIKIISGQFLSDKKVGTYVEVDMYGLPTDTFRKEFRTRVVPNNGLNPIYGDDSVFLFRKVVLPDLAVLRIGVYEDTGKLIGQRVLPLEGLQSGYRHISLRTEGNFPLSLPTIFCKITQTTYIPEGLVDLVDALSDPRAYLSKEEKRMKQLADMGIETSDIVDV--PTTGKPFKKPPDKKSENSNQEPLTPNLANKSGQSNNST----------VSTPVVGFSNNKKDDKKDEPKFDNISLVLLETDKTFQKLIKRQTRELENLRKKHEKDSAILHKSQTIVTDKLNANHAREINKKVKVKGENEESDMIEEVQKNQMVDLVKTHTDEWTSMKLQHRKEEHDLCMSFLESRQELLLKVMKEVQEDQKKELKIIQEREIKEMKAQQTKASIDANKNVINDRKLKNKAERDRRIRELNDINTKRFIDQRKAQAQKQDR 1164

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Planmine SMEST
Match: SMESG000049234.1 (SMESG000049234.1)

HSP 1 Score: 1315.83 bits (3404), Expect = 0.000e+0
Identity = 671/1267 (52.96%), Postives = 879/1267 (69.38%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDL-EIAEDPD---LIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIE---------------------------------------LVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            MTSDIAKRQRTVPSSK +EF WR+ + ++L  GA FD YD++ N LE NCLV+VDE+GFF+ WKSE+ E  V D+  +SDV+ G K K++K+ + L ++  + ++DR + I   +D VN+     + +D++I  FW+ +LR + HN K  N+CPM QLKKHWLRLCL V  N  IP++ ++KTFASG+ EK++FQSLKEL LP  K  ++DPS FTFEKFY L + ICPRTDI+++F  LS  KD++T +++I +LNE QRDPRLNEIL+P++N+++V+YILD  E +   + +G++S++CFYRYLMSD+NAPVFLDRL++ QDMDQPLAHYYINSSHNTYLTGRQF GKSSV++YRQVLL+GCRC+ELDCWDGKG+DQEPIITHGKAMC+DILF+DVIYAIRD AFVTS  P+ LSFENHCSKPQQYK+AKYCE+VLG+ LLTKPI+KH+L   VPLPSP KL+ KILIKNKRL  E EK QL+MFLKGQT++ Q+  E AEDPD   ++ GEDG +N +                                         N  II  N  + +  + K E N    +   E S+ +  + VK +K    +K+++K       G  +AE   ++Q +   Y +   TTN+HPYLS++VNY QPVKF GF+I  E+   FHMSSFSET ALG++KN+AIE                                       LV+YNK QLSRIYPRGNRVDS+NF+PQIFWNAGCQMVALNFQ+ DLAMQLNQG+FEYN NSGY+LKPEFMRR ER+FDPFSESPMDGVIAAT E+KIISGQFLS+KK+GTYVEVDMYGLPTDT RKEFRTRVVP NGLNP+Y +DS F+FRKV+LPDLAVLRIGV+E+TGKLIGQRVLPL+GLQ+G+RHISLR+EGNFP +L ++FCKIT +TY+P+G    VDALSDPRA++S+EE ++K +A+MG ETS+I D+   T+    K+   +     + +    N+     Q +++T          V    + +S NK  D KD+  F+ I+   L   KT  K +KRQ +E  NL+K+  K+   L KS ++ T+KL +   ++ +   K K EN+    + +    +M+ L + +  E   +   H   E +L +   +  +E  LKV+ ++Q  Q+K L+++Q+RE+KEM  QQTK+S++AN+ VI D   +NKAERDRR+REL D N KRF+DQR+AQ  K +R
Sbjct:    1 MTSDIAKRQRTVPSSKAFEFNWRQPVSDDLINGAHFDRYDEDSNSLESNCLVRVDEYGFFVHWKSEQGEGQVLDLSQVSDVRFGSKPKEDKICAVLLERISNPLDDRIVTICSGTDLVNISYTHMVSQDNEIATFWINNLRPLTHNTKMNNVCPMIQLKKHWLRLCLGVKANGMIPVRSISKTFASGKTEKIIFQSLKELGLPFGKNDEIDPSSFTFEKFYELYHKICPRTDIEEIFKELSNSKDFITTEKIIEYLNEVQRDPRLNEILFPFANKDTVKYILDNNEPSEEYRKEGKLSIECFYRYLMSDDNAPVFLDRLNICQDMDQPLAHYYINSSHNTYLTGRQFGGKSSVEIYRQVLLSGCRCIELDCWDGKGEDQEPIITHGKAMCTDILFKDVIYAIRDTAFVTSEMPIILSFENHCSKPQQYKLAKYCEDVLGDLLLTKPIDKHELSQAVPLPSPLKLRKKILIKNKRLKPEVEKQQLEMFLKGQTEIIQEENENAEDPDPLVMVDGEDGPMNEI-----------------------------------------NPTIIVKNDTDPHPEMHKTELNGLLKVK--EQSDTQLNIKVKEEKEPDSRKNASKK------GSLTAE---EEQAMLAQYHYIGATTNIHPYLSAMVNYTQPVKFQGFDIAEEEAYHFHMSSFSETVALGYLKNEAIEFCFVLMHDYILLLDLNIHYHMSSFNENVGLGLIRRDCIALVDYNKRQLSRIYPRGNRVDSANFMPQIFWNAGCQMVALNFQTPDLAMQLNQGKFEYNGNSGYLLKPEFMRRPERSFDPFSESPMDGVIAATLEIKIISGQFLSDKKVGTYVEVDMYGLPTDTFRKEFRTRVVPNNGLNPIYGDDSVFLFRKVVLPDLAVLRIGVYEDTGKLIGQRVLPLEGLQSGYRHISLRTEGNFPLSLPTIFCKITQTTYIPEGLVDLVDALSDPRAYLSKEEKRMKQLADMGIETSDIVDV--PTTGKPFKKPPDKKSENSNQEPLTPNLANKSGQSNNST----------VSTPVVGFSNNKKDDKKDEPKFDNISLVLLETDKTFQKLIKRQTRELENLRKKHEKDSAILHKSQTIVTDKLNANHAREINKKVKVKGENEESDMIEEVQKNQMVDLVKTHTDEWTSMKLQHRKEEHDLCMSFLESRQELLLKVMKEVQEDQKKELKIIQEREIKEMKAQQTKASIDANKNVINDRKLKNKAERDRRIRELNDINTKRFIDQRKAQAQKQDR 1203

[Close]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Planmine SMEST
Match: SMESG000049234.1 (SMESG000049234.1)

HSP 1 Score: 1311.21 bits (3392), Expect = 0.000e+0
Identity = 671/1279 (52.46%), Postives = 879/1279 (68.73%), Query Frame = 2

Query:  239 MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNCLVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKTQSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAANICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKELNLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTNDRMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVDCFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGKSSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIYAIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKHQLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDL-EIAEDPD---LIAGEDGALNVVSSXXXXXXXXXXXXXXXINRLKSYEICGSKQTRFSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVKHKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPYLSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIE---------------------------------------------------LVNYNKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGRFEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLSEKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVILPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSSLFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIKDLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQIKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFSNLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQRSIQEMLSLTEKNEQEKNKLCFNHXXXXXXXXXXXXXXXXXXYLKVLSQLQLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRLRELCDYNAKRFLDQRRAQQMKHNR 3910
            MTSDIAKRQRTVPSSK +EF WR+ + ++L  GA FD YD++ N LE NCLV+VDE+GFF+ WKSE+ E  V D+  +SDV+ G K K++K+ + L ++  + ++DR + I   +D VN+     + +D++I  FW+ +LR + HN K  N+CPM QLKKHWLRLCL V  N  IP++ ++KTFASG+ EK++FQSLKEL LP  K  ++DPS FTFEKFY L + ICPRTDI+++F  LS  KD++T +++I +LNE QRDPRLNEIL+P++N+++V+YILD  E +   + +G++S++CFYRYLMSD+NAPVFLDRL++ QDMDQPLAHYYINSSHNTYLTGRQF GKSSV++YRQVLL+GCRC+ELDCWDGKG+DQEPIITHGKAMC+DILF+DVIYAIRD AFVTS  P+ LSFENHCSKPQQYK+AKYCE+VLG+ LLTKPI+KH+L   VPLPSP KL+ KILIKNKRL  E EK QL+MFLKGQT++ Q+  E AEDPD   ++ GEDG +N +                                         N  II  N  + +  + K E N    +   E S+ +  + VK +K    +K+++K       G  +AE   ++Q +   Y +   TTN+HPYLS++VNY QPVKF GF+I  E+   FHMSSFSET ALG++KN+AIE                                                   LV+YNK QLSRIYPRGNRVDS+NF+PQIFWNAGCQMVALNFQ+ DLAMQLNQG+FEYN NSGY+LKPEFMRR ER+FDPFSESPMDGVIAAT E+KIISGQFLS+KK+GTYVEVDMYGLPTDT RKEFRTRVVP NGLNP+Y +DS F+FRKV+LPDLAVLRIGV+E+TGKLIGQRVLPL+GLQ+G+RHISLR+EGNFP +L ++FCKIT +TY+P+G    VDALSDPRA++S+EE ++K +A+MG ETS+I D+   T+    K+   +     + +    N+     Q +++T          V    + +S NK  D KD+  F+ I+   L   KT  K +KRQ +E  NL+K+  K+   L KS ++ T+KL +   ++ +   K K EN+    + +    +M+ L + +  E   +   H   E +L +   +  +E  LKV+ ++Q  Q+K L+++Q+RE+KEM  QQTK+S++AN+ VI D   +NKAERDRR+REL D N KRF+DQR+AQ  K +R
Sbjct:    1 MTSDIAKRQRTVPSSKAFEFNWRQPVSDDLINGAHFDRYDEDSNSLESNCLVRVDEYGFFVHWKSEQGEGQVLDLSQVSDVRFGSKPKEDKICAVLLERISNPLDDRIVTICSGTDLVNISYTHMVSQDNEIATFWINNLRPLTHNTKMNNVCPMIQLKKHWLRLCLGVKANGMIPVRSISKTFASGKTEKIIFQSLKELGLPFGKNDEIDPSSFTFEKFYELYHKICPRTDIEEIFKELSNSKDFITTEKIIEYLNEVQRDPRLNEILFPFANKDTVKYILDNNEPSEEYRKEGKLSIECFYRYLMSDDNAPVFLDRLNICQDMDQPLAHYYINSSHNTYLTGRQFGGKSSVEIYRQVLLSGCRCIELDCWDGKGEDQEPIITHGKAMCTDILFKDVIYAIRDTAFVTSEMPIILSFENHCSKPQQYKLAKYCEDVLGDLLLTKPIDKHELSQAVPLPSPLKLRKKILIKNKRLKPEVEKQQLEMFLKGQTEIIQEENENAEDPDPLVMVDGEDGPMNEI-----------------------------------------NPTIIVKNDTDPHPEMHKTELNGLLKVK--EQSDTQLNIKVKEEKEPDSRKNASKK------GSLTAE---EEQAMLAQYHYIGATTNIHPYLSAMVNYTQPVKFQGFDIAEEEAYHFHMSSFSETVALGYLKNEAIEFVKYPKFLFFPLNCFVLMHDYILLLDLNIHYHMSSFNENVGLGLIRRDCIALVDYNKRQLSRIYPRGNRVDSANFMPQIFWNAGCQMVALNFQTPDLAMQLNQGKFEYNGNSGYLLKPEFMRRPERSFDPFSESPMDGVIAATLEIKIISGQFLSDKKVGTYVEVDMYGLPTDTFRKEFRTRVVPNNGLNPIYGDDSVFLFRKVVLPDLAVLRIGVYEDTGKLIGQRVLPLEGLQSGYRHISLRTEGNFPLSLPTIFCKITQTTYIPEGLVDLVDALSDPRAYLSKEEKRMKQLADMGIETSDIVDV--PTTGKPFKKPPDKKSENSNQEPLTPNLANKSGQSNNST----------VSTPVVGFSNNKKDDKKDEPKFDNISLVLLETDKTFQKLIKRQTRELENLRKKHEKDSAILHKSQTIVTDKLNANHAREINKKVKVKGENEESDMIEEVQKNQMVDLVKTHTDEWTSMKLQHRKEEHDLCMSFLESRQELLLKVMKEVQEDQKKELKIIQEREIKEMKAQQTKASIDANKNVINDRKLKNKAERDRRIRELNDINTKRFIDQRKAQAQKQDR 1215

The following BLAST results are available for this feature:

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Human
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Celegans
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Fly
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Zebrafish
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Xenopus
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Mouse
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. UniProt/SwissProt
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. TrEMBL
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Cavefish
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Sea Lamprey
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Yeast
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Nematostella
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Medaka
BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Planmine SMEST

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PLCB4	3.264e-173	57.14	phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGN...	[more]
PLCB4	2.375e-173	57.14	phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGN...	[more]
PLCB4	2.375e-173	57.14	phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGN...	[more]
PLCB4	2.137e-173	57.14	phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGN...	[more]
PLCB4	2.137e-173	57.14	phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGN...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
egl-8	1.784e-7	46.18	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
egl-8	1.896e-7	46.38	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
egl-8	2.104e-7	45.00	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
egl-8	2.038e-7	45.19	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
egl-8	6.142e-152	46.21	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
norpA	1.823e-165	52.43	gene:FBgn0262738 transcript:FBtr0343599	[more]
norpA	1.823e-165	52.43	gene:FBgn0262738 transcript:FBtr0100670	[more]
norpA	1.823e-165	52.43	gene:FBgn0262738 transcript:FBtr0100671	[more]
norpA	2.116e-162	52.02	gene:FBgn0262738 transcript:FBtr0070651	[more]
norpA	2.116e-162	52.02	gene:FBgn0262738 transcript:FBtr0301475	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PLCB4	1.049e-163	55.33	phospholipase C beta 4 [Source:NCBI gene;Acc:10053...	[more]
plcb3	3.880e-99	38.17	phospholipase C, beta 3 (phosphatidylinositol-spec...	[more]
plcb3	3.937e-99	38.17	phospholipase C, beta 3 (phosphatidylinositol-spec...	[more]
plch1	4.606e-91	33.47	phospholipase C, eta 1 [Source:ZFIN;Acc:ZDB-GENE-0...	[more]
CABZ01072157.1	5.880e-89	51.00	pep chromosome:GRCz11:17:2348540:2386569:-1 gene:E...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ppp1r16b	2.226e-164	56.70	protein phosphatase 1 regulatory subunit 16B [Sour...	[more]
ppp1r16b	7.669e-164	56.70	protein phosphatase 1 regulatory subunit 16B [Sour...	[more]
ppp1r16b	1.505e-164	56.70	protein phosphatase 1 regulatory subunit 16B [Sour...	[more]
ppp1r16b	4.054e-164	56.70	protein phosphatase 1 regulatory subunit 16B [Sour...	[more]
ppp1r16b	5.509e-161	56.70	protein phosphatase 1 regulatory subunit 16B [Sour...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Plcb4	6.857e-172	57.56	phospholipase C, beta 4 [Source:MGI Symbol;Acc:MGI...	[more]
Plcb4	6.857e-172	57.56	phospholipase C, beta 4 [Source:MGI Symbol;Acc:MGI...	[more]
Plcb4	1.879e-157	57.56	phospholipase C, beta 4 [Source:MGI Symbol;Acc:MGI...	[more]
Plcb4	9.386e-149	57.81	phospholipase C, beta 4 [Source:MGI Symbol;Acc:MGI...	[more]
Plcb1	1.638e-107	45.00	phospholipase C, beta 1 [Source:MGI Symbol;Acc:MGI...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q15147\|PLCB4_HUMAN	1.026e-172	57.14	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
sp\|Q9QW07\|PLCB4_RAT	8.088e-171	57.35	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
sp\|Q07722\|PLCB4_BOVIN	1.011e-173	47.88	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
sp\|P13217\|PIPA_DROME	2.121e-161	52.02	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
sp\|G5EBH0\|PLCB_CAEEL	2.266e-144	46.21	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4Z2CYF8	0.000e+0	53.46	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
A0A074ZXA5	0.000e+0	53.50	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
A0A4S2KEP2	0.000e+0	53.26	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
A0A0X3P0N3	0.000e+0	52.76	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
A0A0R3U5L3	0.000e+0	50.97	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PLCB4	0.000e+0	49.07	phospholipase C beta 4 [Source:NCBI gene;Acc:10302...	[more]
PLCB4	0.000e+0	48.90	phospholipase C beta 4 [Source:NCBI gene;Acc:10302...	[more]
PLCB4	0.000e+0	47.53	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
PLCB4	0.000e+0	47.04	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]
PLCB4	1.855e-154	58.40	phospholipase C beta 4 [Source:NCBI gene;Acc:10302...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PLCB4	1.145e-168	45.79	phospholipase C beta 4 [Source:HGNC Symbol;Acc:HGN...	[more]
PLCB1	3.592e-105	40.81	phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGN...	[more]
PLCB1	5.743e-95	54.27	phospholipase C beta 1 [Source:HGNC Symbol;Acc:HGN...	[more]
PLCD4	6.862e-53	42.86	phospholipase C delta 4 [Source:HGNC Symbol;Acc:HG...	[more]
plcd3b	1.236e-49	42.15	phospholipase C, delta 3b [Source:ZFIN;Acc:ZDB-GEN...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
PLC1	2.857e-29	42.24	Phospholipase C; hydrolyzes phosphatidylinositol 4...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO42237	1.462e-117	44.59	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO43813	2.052e-113	59.06	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38229	5.588e-54	37.85	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO28963	3.067e-52	40.73	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31556	2.010e-50	39.04	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PLCB4	0.000e+0	48.06	phospholipase C beta 4 [Source:NCBI gene;Acc:10004...	[more]
PLCB1	2.065e-103	41.91	phospholipase C beta 1 [Source:NCBI gene;Acc:10117...	[more]
PLCB1	3.391e-103	41.91	phospholipase C beta 1 [Source:NCBI gene;Acc:10117...	[more]
PLCB1	5.729e-103	41.91	phospholipase C beta 1 [Source:NCBI gene;Acc:10117...	[more]
ENSORLT00000042446.1	7.469e-99	43.62	1-phosphatidylinositol 4,5-bisphosphate phosphodie...	[more]

BLAST of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000024212.1	0.000e+0	97.03	SMESG000024212.1	[more]
SMESG000049234.1	0.000e+0	54.64	SMESG000049234.1	[more]
SMESG000049234.1	0.000e+0	53.99	SMESG000049234.1	[more]
SMESG000049234.1	0.000e+0	52.96	SMESG000049234.1	[more]
SMESG000049234.1	0.000e+0	52.46	SMESG000049234.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30029890 ID=SMED30029890|Name=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase|organism=Schmidtea mediterranea sexual|type=transcript|length=5190bp
GTCTAATAATTTCCTATTGATTTTTCTGTATAAAATATTAAGAAATATAA
TTATATATAAGTTATATATAAATTTTGATTTTAAATCTCTTCAATAATAT
TTTAATCATTTTTTCTCTCGACAATGCGGATATTTGCCGGATGTAAAATA
AATAAATGATTCCAGTGTTTTCTAATTAAATTAATCAATGAATTGAGGAA
TTTTATTTTGTAATTTATCAAAATTTACAATTTGATTTATGACGTCTGAC
ATAGCGAAACGTCAGCGGACGGTACCCAGCTCAAAAATATATGAATTTCA
GTGGCGTAGAAATATTCCAGAAGAATTAAAAAAAGGAGCACTATTTGATT
TCTATGATGATGAACTGAATATTTTAGAAGTAAATTGTCTTGTAAAAGTT
GATGAGTTTGGATTCTTTCTCTCGTGGAAAAGTGAAAAATCGGAGGCGTA
TGTGTATGACATGCCACTTATCAGTGATGTAAAATCTGGAGTGAAAATAA
AGGATGAAAAAGTTCTGAGCCAATTGCAAGATAAAACCCAGTCAAACATA
GAAGATCGCACGCTGGTGATTTCCGTCAATTCGGATTTTGTCAATCTTCA
CACGTTACTTTTTATTGGGAAGGATTCAAAAATTGTAAATTTTTGGGTGA
CATCTTTACGATCAGTTTTTCACAATATCAAAGCAGCTAACATATGTCCA
ATGACACAACTCAAAAAACACTGGCTCAGATTATGCTTGCTAGTCAATGT
CAATAACAAAATTCCGCTTAAACTTGTAGCCAAAACTTTTGCATCCGGTA
GAAACGAGAAATTGGTGTTTCAAAGTCTTAAAGAATTGAATCTTCCATGT
GAAAAGACTGCAGATGTCGATCCAAGTCAGTTCACATTTGAAAAGTTCTA
TAATCTTTTAAATATGATCTGCCCAAGAACAGATATACAAGATTTATTTA
ACAGTTTGTCTGAAGGTAAAGATTATTTAACCAATGACAGAATGATTCGG
TTTTTGAATGAAACTCAAAGAGATCCACGACTAAATGAAATTCTATATCC
ATATTCGAACAGAAATTCTGTACAATATATTCTTGATACTTATGAATTAA
ATCCCGTGAGAAAAAGCCAAGGAGAAATATCAGTTGACTGTTTTTATCGA
TACCTTATGAGCGATGAAAACGCCCCAGTATTTCTAGATCGTCTGGACCT
TCATCAAGACATGGATCAACCTTTAGCTCACTATTACATAAATTCTTCAC
ATAATACATACTTAACTGGAAGACAGTTCAGAGGAAAATCTTCAGTTGAT
ATGTATCGCCAAGTTTTATTAGCAGGATGTCGATGCGTTGAGCTGGATTG
TTGGGATGGGAAAGGCGATGATCAGGAACCGATTATAACGCACGGGAAAG
CTATGTGTTCTGATATTTTATTTAGGGATGTAATTTACGCAATTCGTGAT
TGCGCTTTTGTCACCAGTCCATATCCGGTATTTTTATCCTTTGAAAATCA
TTGCAGCAAGCCTCAACAGTACAAAATTGCAAAATATTGTGAAGAAGTTC
TAGGGGAATATTTGTTGACAAAACCAATTGAAAAACATCAACTTGAAGCC
GGAGTCCCACTTCCATCTCCAGAAAAACTGAAATACAAAATTCTAATTAA
AAATAAGCGATTGCCACAAGAAACTGAAAAAATCCAGTTGGATATGTTTC
TAAAAGGACAAACAGATTTGACTCAAGATTTGGAAATTGCTGAAGATCCC
GACTTGATTGCTGGTGAAGATGGAGCTTTAAATGTTGTCTCTTCGGAGGA
TGACGACGATGATGACGACGATGCCGAAGCCGAGGCTGAAATCAACAGAT
TAAAATCTTATGAAATTTGCGGATCAAAACAAACAAGATTTTCATTTTCT
AGCAGTGTACCAAATACTCCAATTATCAACAGCAACATCCTAGAAGCAAA
TATAGGCATTCTAAAGCAGGAAACCAATAGTCATAGTCATATAACCAAAA
TGGAGTCTTCGAATGCTGAATCAACTGTAATTGTGAAACATAAGAAATAT
TTACATGAGAAAAAGAGCTCGGCCAAGGATTTGACATCATTAATGGTCGG
CGATGAATCTGCAGAAATAGAGAAAGACGATCAAACTGTTGGAATGAATT
ATAGACACACAAGTGGCACCACAAACGTACATCCCTACCTCTCTTCATTG
GTAAATTATGCACAGCCTGTAAAATTTCTTGGTTTCAACATTCCCCCAGA
GAAACGTTGTTGCTTCCACATGTCATCCTTCAGTGAGACTGCAGCTCTCG
GACACATGAAGAACGATGCTATTGAACTTGTCAATTACAATAAATACCAA
CTAAGCCGAATTTATCCCAGAGGAAACAGAGTTGATTCAAGTAACTTCCT
GCCACAAATTTTTTGGAATGCTGGATGTCAAATGGTTGCTTTGAATTTTC
AGAGTTCAGATTTAGCTATGCAATTAAATCAAGGCCGTTTTGAATATAAC
AATAATTCTGGTTATATGTTGAAACCGGAATTCATGCGACGATCAGAAAG
AGCTTTTGATCCGTTTTCAGAATCACCGATGGATGGAGTGATTGCAGCTA
CATGTGAAGTAAAGATAATTTCCGGTCAGTTTCTTTCAGAAAAGAAAATC
GGTACATATGTTGAAGTAGATATGTATGGATTACCAACAGATACAATACG
TAAGGAATTCAGAACGAGAGTCGTGCCCGCAAATGGTCTTAATCCACTTT
ATCCCGAAGATAGCAATTTTGTTTTTAGGAAAGTCATTTTACCAGATCTT
GCTGTATTACGAATTGGTGTTTTTGAAGAAACAGGAAAGTTGATTGGACA
GAGAGTTCTTCCTCTCGATGGATTGCAGACCGGATTTCGGCATATTTCCC
TTCGAAGCGAAGGAAACTTTCCATGTGCTCTTTCATCTTTGTTTTGTAAA
ATAACGTTGTCAACTTACGTGCCTGATGGATTTGCTAGTTTCGTTGATGC
CCTATCAGATCCTAGAGCTCATATCAGTAGAGAAGAACACAAGCTTAAAC
TCATGGCAAATATGGGATTTGAAACTTCTGAAATAAAGGATCTCTCGCCT
TCTACATCATCATTGAATAAAAAACAGACAAAGAAAGAAATTATGCGGCG
ACAGTCCACAGATGGAACAGATTCCAATATGAAGTATGGAATAAATCAGG
AATCATCAACTACTAAAATAAATTCAAACGTTTATCAAATTAAAGTTCGA
AATGAAAATTTAGTTTATAGTCCAAACAAATCCAAAGATTTTAAAGATGA
TGCTATTTTTGAAGAAATCACACCCGAATCTCTAAATGAAACAAAAACGA
TTGTTAAATATTTAAAAAGACAAAATAAAGAATTCTCAAATCTGCAGAAA
CGCCAAATTAAAGAGATTAATGAACTATTGAAGTCGCACTCCTTAAGCAC
CGAGAAATTGGAAAGTTGTCTTGGAAAACAAAAATCAATAATGCATAAAA
AGAAAACCGAAAATCAAATGAAAATCGACATGAATCAAAGAAGCATTCAA
GAAATGTTAAGTCTTACGGAGAAAAATGAACAAGAAAAAAATAAATTATG
TTTCAATCATTTGAACGCTGAGCAGAACTTAAAGTTATTAAATCAGCAAC
AGTTGAAAGAAGCTTATTTAAAGGTCCTGAGTCAGTTGCAATTAGGTCAG
CGAAAATATCTTAGATTGGTTCAAAAACGCGAAGTAAAAGAAATGCATAA
TCAACAAACGAAGTCTTCAATGGAAGCAAATCGAATAGTAATAACTGACA
GTAACTTCAGAAATAAAGCAGAAAGAGATAGGCGATTGAGAGAACTTTGC
GATTACAACGCAAAGAGGTTTCTAGATCAAAGAAGAGCTCAACAAATGAA
GCACAACAGGCAAGTAGAACTTCTTGAACAGAAACATGAAGAACAAAAGA
AACGATTATTTGAATTCATTGAAGAAGTAATTAATTTAATTTCTTGTATT
TTCACTTCACTTAATGATGATATAGCGAATTCATTTCTTGTGTGGTTTTA
TTTCCTCTTTTTCGAGATCTTAAAAGATTAAGTTTAGAATAAGAATTATC
TTGGAAAGGGGATGATTCTTGGATGATTCTCGTTCATTTCAGTACATTCA
CAATTTGCATGATGATATCACTCTTTTAGCTCAAACTTTAGTAAAGTTAT
CCCTTTTATGTTTCGTTTGAAGCTTCCATATTTTACTTTTGAAAGGAGCA
AATTTCTACCTTGCTCCTGAAATAAGTTTTTGATTTTCAAATGACTTGTA
TTCAAACATTTAATATGAAAAGTTAAAATATTTCTAAATGAAATCTTCCG
AGCACGACTAATGCTAATTATGCTTGGTGCTACCATGATAGTATGTTCTC
TATCAACCAAATCTGATTTTGTAATCTGTTTTATGCTATGCCATGTTTTA
TAAAACTTTATGTCTTTCTAATCAGTGAATTCATTGAGGAAAATTGGGGC
AAGTGACTTATTTATGAAAACCTTTAAGTTTAAGAACTAAGAACTGCTTA
AACTCCCATTTTGAAATTCTTTGTCATGAAGAAAATTCGGCAGAGATATT
AACAAAAATAATAAGGAGCAGCTAGGTTAGACTATAATGAGAAAACTTGG
ATTTAACTCTTTGATTTTCTCCGGGATCCCTTTCAAAATATTAGTCGGTC
ACTATCCTGTTGGAAAATCACTTATTTACTATTAATTGAAACTACTTCAA
CTATCCTAAAGAGAATAACTTAGTATAGTTTTTGGAATTTATCCCGTTCC
TGGCTAAATAGGGATATTGTTCTTATTTAATTTAAGGTTTCACTTAAACA
TTTAATAACGGCAAATAAACCTTTAGCATGATTAAGGAATTATGTCAACA
ATTCTGATTTAGAAACTGATTCTTATTTGGTTAGAATTTCTCTGATTTCT
TAAACAATTTGTCTCAAACAAATAACTATCTTTTTCTAACTCAAGAGAAA
ATATCGAAAATATCGAAAAAGCCATCGACATCTTCATGAAATCGCGAGAT
CTTAATTTCTACTTGAATAGTTACTAGAAGATTGTAAGAAACTGAATCAT
GTTCTTTTAAAAAGTTTTTGAAAAAGTTATCATAAATCCGACAAAATTAT
TTGATTAATATACACCATTTCTAAATTGAATCTGCTATAA

protein sequence of SMED30029890-orf-1

>SMED30029890-orf-1 ID=SMED30029890-orf-1|Name=SMED30029890-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1281bp
MTSDIAKRQRTVPSSKIYEFQWRRNIPEELKKGALFDFYDDELNILEVNC
LVKVDEFGFFLSWKSEKSEAYVYDMPLISDVKSGVKIKDEKVLSQLQDKT
QSNIEDRTLVISVNSDFVNLHTLLFIGKDSKIVNFWVTSLRSVFHNIKAA
NICPMTQLKKHWLRLCLLVNVNNKIPLKLVAKTFASGRNEKLVFQSLKEL
NLPCEKTADVDPSQFTFEKFYNLLNMICPRTDIQDLFNSLSEGKDYLTND
RMIRFLNETQRDPRLNEILYPYSNRNSVQYILDTYELNPVRKSQGEISVD
CFYRYLMSDENAPVFLDRLDLHQDMDQPLAHYYINSSHNTYLTGRQFRGK
SSVDMYRQVLLAGCRCVELDCWDGKGDDQEPIITHGKAMCSDILFRDVIY
AIRDCAFVTSPYPVFLSFENHCSKPQQYKIAKYCEEVLGEYLLTKPIEKH
QLEAGVPLPSPEKLKYKILIKNKRLPQETEKIQLDMFLKGQTDLTQDLEI
AEDPDLIAGEDGALNVVSSEDDDDDDDDAEAEAEINRLKSYEICGSKQTR
FSFSSSVPNTPIINSNILEANIGILKQETNSHSHITKMESSNAESTVIVK
HKKYLHEKKSSAKDLTSLMVGDESAEIEKDDQTVGMNYRHTSGTTNVHPY
LSSLVNYAQPVKFLGFNIPPEKRCCFHMSSFSETAALGHMKNDAIELVNY
NKYQLSRIYPRGNRVDSSNFLPQIFWNAGCQMVALNFQSSDLAMQLNQGR
FEYNNNSGYMLKPEFMRRSERAFDPFSESPMDGVIAATCEVKIISGQFLS
EKKIGTYVEVDMYGLPTDTIRKEFRTRVVPANGLNPLYPEDSNFVFRKVI
LPDLAVLRIGVFEETGKLIGQRVLPLDGLQTGFRHISLRSEGNFPCALSS
LFCKITLSTYVPDGFASFVDALSDPRAHISREEHKLKLMANMGFETSEIK
DLSPSTSSLNKKQTKKEIMRRQSTDGTDSNMKYGINQESSTTKINSNVYQ
IKVRNENLVYSPNKSKDFKDDAIFEEITPESLNETKTIVKYLKRQNKEFS
NLQKRQIKEINELLKSHSLSTEKLESCLGKQKSIMHKKKTENQMKIDMNQ
RSIQEMLSLTEKNEQEKNKLCFNHLNAEQNLKLLNQQQLKEAYLKVLSQL
QLGQRKYLRLVQKREVKEMHNQQTKSSMEANRIVITDSNFRNKAERDRRL
RELCDYNAKRFLDQRRAQQMKHNRQVELLEQKHEEQKKRLFEFIEEVINL
ISCIFTSLNDDIANSFLVWFYFLFFEILKD*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000099	neuron
PLANA:0000101	muscle cell
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR037862	PLC-beta_PH
IPR035892	C2_domain_sf
IPR001192	PI-PLC_fam
IPR000909	PLipase_C_PInositol-sp_X_dom
IPR000008	C2_dom
IPR001711	PLipase_C_Pinositol-sp_Y
IPR011992	EF-hand-dom_pair
IPR011993	PH-like_dom_sf
IPR009535	PLC-beta_CS
IPR015359	PLC_EF-hand-like
IPR016280	PLC-beta
IPR017946	PLC-like_Pdiesterase_TIM-brl

Vocabulary: **biological process**
Term	Definition
GO:0035556	intracellular signal transduction
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0016042	lipid catabolic process

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0005509	calcium ion binding
GO:0008081	phosphoric diester hydrolase activity
GO:0004871	signal transducer activity
GO:0016787	hydrolase activity

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 1212..1246
None	No IPR available	COILS	Coil	Coil	coord: 1099..1119
None	No IPR available	GENE3D	G3DSA:2.30.29.240		coord: 14..228 e-value: 1.1E-56 score: 193.5
None	No IPR available	GENE3D	G3DSA:1.10.238.10		coord: 229..319 e-value: 1.5E-29 score: 103.6
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 953..976
None	No IPR available	PANTHER	PTHR10336:SF106	1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4	coord: 20..1069
None	No IPR available	PROSITE	PS50007	PIPLC_X_DOMAIN	coord: 323..473 score: 59.72
None	No IPR available	CDD	cd08591	PI-PLCc_beta	coord: 322..754 e-value: 4.34552E-160 score: 476.83
None	No IPR available	CDD	cd00275	C2_PLC_like	coord: 788..908 e-value: 9.8609E-37 score: 133.05
None	No IPR available	SUPERFAMILY	SSF50729	PH domain-like	coord: 25..151
None	No IPR available	SUPERFAMILY	SSF49562	C2 domain (Calcium/lipid-binding domain, CaLB)	coord: 790..906
None	No IPR available	SUPERFAMILY	SSF69989	C-terminal domain of PLC-beta	coord: 1021..1249
IPR001192	Phosphoinositide phospholipase C family	PRINTS	PR00390	PHPHLIPASEC	coord: 328..346 score: 72.79 coord: 457..474 score: 58.39 coord: 354..374 score: 59.12 coord: 874..884 score: 43.4 coord: 726..744 score: 59.78 coord: 705..726 score: 60.72
IPR001192	Phosphoinositide phospholipase C family	PANTHER	PTHR10336	PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN	coord: 20..1069
IPR000008	C2 domain	SMART	SM00239	C2_3c	coord: 788..888 e-value: 2.3E-8 score: 43.8
IPR000008	C2 domain	PROSITE	PS50004	C2	coord: 774..873 score: 19.647
IPR000909	Phosphatidylinositol-specific phospholipase C, X domain	SMART	SM00148	plcx_3	coord: 323..473 e-value: 2.7E-81 score: 286.1
IPR000909	Phosphatidylinositol-specific phospholipase C, X domain	PFAM	PF00388	PI-PLC-X	coord: 325..473 e-value: 4.6E-61 score: 204.6
IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain	SMART	SM00149	plcy_3	coord: 651..767 e-value: 5.4E-63 score: 225.3
IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain	PFAM	PF00387	PI-PLC-Y	coord: 651..765 e-value: 9.3E-40 score: 135.6
IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain	PROSITE	PS50008	PIPLC_Y_DOMAIN	coord: 651..767 score: 52.3
IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	GENE3D	G3DSA:3.20.20.190		coord: 320..554 e-value: 1.1E-77 score: 263.4 coord: 563..778 e-value: 9.7E-51 score: 174.8
IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily	SUPERFAMILY	SSF51695	PLC-like phosphodiesterases	coord: 323..768
IPR037862	PLC-beta, PH domain	PFAM	PF17787	PH_14	coord: 26..151 e-value: 9.7E-27 score: 93.4
IPR037862	PLC-beta, PH domain	CDD	cd13361	PH_PLC_beta	coord: 30..154 e-value: 3.62199E-30 score: 114.204
IPR016280	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta	PIRSF	PIRSF000956	PLC-beta	coord: 10..1255 e-value: 0.0 score: 1357.5
IPR015359	Phosphoinositide-specific phospholipase C, EF-hand-like domain	PFAM	PF09279	EF-hand_like	coord: 225..311 e-value: 1.1E-7 score: 32.2
IPR009535	Phospholipase C-beta, conserved site	PFAM	PF06631	DUF1154	coord: 1024..1060 e-value: 1.1E-6 score: 28.6
IPR035892	C2 domain superfamily	GENE3D	G3DSA:2.60.40.150		coord: 780..948 e-value: 1.5E-48 score: 166.7
IPR011992	EF-hand domain pair	SUPERFAMILY	SSF47473	EF-hand	coord: 152..322