Sterol regulatory element-binding protein cleavage-activating protein

Overview
NameSterol regulatory element-binding protein cleavage-activating protein
Smed IDSMED30029861
Length (bp)3381
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Sterol regulatory element-binding protein cleavage-activating protein (SMED30029861) t-SNE clustered cells

Violin plots show distribution of expression levels for Sterol regulatory element-binding protein cleavage-activating protein (SMED30029861) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Sterol regulatory element-binding protein cleavage-activating protein (SMED30029861) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Sterol regulatory element-binding protein cleavage-activating protein (SMED30029861) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30029861

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30029861h1SMcG0016533 dd_Smed_v4_12222_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Human
Match: SCAP (SREBF chaperone [Source:HGNC Symbol;Acc:HGNC:30634])

HSP 1 Score: 282.722 bits (722), Expect = 4.314e-78
Identity = 199/577 (34.49%), Postives = 297/577 (51.47%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKL--------------IGYVQQIIVQN-----HAELVESDINNPIEIVYEALSECFKIVNEIKFR--------HDYLEACLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
               R KI + +YN+G  CAS+PI I+      I+  CYPLL        P        +        D+K               + YVQQI V++     H  L+       +++    LS  F++V EI+              E CL+  D+     K  NL P   CL LSP   W+   ++F +D +I+ TI+  +         +K++ FG+P   +G+S ++T+K+   ++Y IT + + Y   FL SL A+L   + + +     +S   + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+           +  E+ L                       +   G    ++ +L           + S  +T   +Q      + +P+RL  +YF A+ R+ QRL+M    VWI  ++
Sbjct:    5 ERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTPVKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLA------VDVFRSPLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVS-LYTRKR--MVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN--------KRLPPEACL---------------------PSAKPVGQPTRYERQLAV---------RPSTPHTIT-LQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILV 532
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Human
Match: SCAP (SREBF chaperone [Source:HGNC Symbol;Acc:HGNC:30634])

HSP 1 Score: 282.722 bits (722), Expect = 4.314e-78
Identity = 199/577 (34.49%), Postives = 297/577 (51.47%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKL--------------IGYVQQIIVQN-----HAELVESDINNPIEIVYEALSECFKIVNEIKFR--------HDYLEACLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
               R KI + +YN+G  CAS+PI I+      I+  CYPLL        P        +        D+K               + YVQQI V++     H  L+       +++    LS  F++V EI+              E CL+  D+     K  NL P   CL LSP   W+   ++F +D +I+ TI+  +         +K++ FG+P   +G+S ++T+K+   ++Y IT + + Y   FL SL A+L   + + +     +S   + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+           +  E+ L                       +   G    ++ +L           + S  +T   +Q      + +P+RL  +YF A+ R+ QRL+M    VWI  ++
Sbjct:    5 ERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTPVKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLA------VDVFRSPLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVS-LYTRKR--MVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN--------KRLPPEACL---------------------PSAKPVGQPTRYERQLAV---------RPSTPHTIT-LQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILV 532
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Human
Match: SCAP (SREBF chaperone [Source:HGNC Symbol;Acc:HGNC:30634])

HSP 1 Score: 183.726 bits (465), Expect = 2.312e-50
Identity = 92/146 (63.01%), Postives = 115/146 (78.77%), Query Frame = 1 
Query:  859 MVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI 1296
            MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+
Sbjct:    1 MVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADL 145
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Human
Match: SCAP (SREBF chaperone [Source:HGNC Symbol;Acc:HGNC:30634])

HSP 1 Score: 79.7221 bits (195), Expect = 2.280e-14
Identity = 55/172 (31.98%), Postives = 81/172 (47.09%), Query Frame = 1 
Query: 1138 IFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
            I I+  G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+           +  E+ L                       +   G    ++ +L           + S  +T   +Q      + +P+RL  +YF A+ R+ QRL+M    VWI  ++
Sbjct:   27 IPIILFGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN--------KRLPPEACL---------------------PSAKPVGQPTRYERQLAV---------RPSTPHTIT-LQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILV 159
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Human
Match: NPC1 (NPC intracellular cholesterol transporter 1 [Source:HGNC Symbol;Acc:HGNC:7897])

HSP 1 Score: 62.7734 bits (151), Expect = 4.645e-9
Identity = 44/154 (28.57%), Postives = 83/154 (53.90%), Query Frame = 1 
Query:  841 SVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKS------IVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRME 1284
            S R++ +V SK+ L  +    V +S+  SLG+  YIG+ + +L   E+ P+LV+ +G++N  ++ ++      +    +D     ++ + L +   ++  +  SE     LG  +  PA+  F L A + +  DF LQIT FV++L +D++R E
Sbjct:  644 SCRRL-LVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPL-TLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLD----QQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQE 791
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Celegans
Match: scp-1 (SREBP Cleavage activating Protein (SCAP) homolog [Source:UniProtKB/TrEMBL;Acc:Q5FC80])

HSP 1 Score: 222.246 bits (565), Expect = 3.710e-59
Identity = 177/634 (27.92%), Postives = 304/634 (47.95%), Query Frame = 1 
Query:    1 MNVKLPQNKNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNT-SFHSNTP---FHQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTI---NSRKRF-IKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGE--ELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNIS---KGHKRKASDINTAAFIQSDGMVPVYIPR---RLIFLYFWAKNRIFQRLVMIVAAVWILFIILY--STNLFHSVFLRNIISLPLQPDIHIDLT-----DDWKLLAMHHWPRLAQIYSINITDRKLFVLP 1833
            MN ++       + +I   Y++YG+ CA+HP   L+  +  +I+  YP +       +TP   F    + +ND +  +  ++    Y+QQ IV        +    P   V  A++  F+I   +       E CL   +    D S+       C+ LSP  +W     KF  D++ + T+   + +  F ++++  G P   TGI   +   +  KI +A+T    +Y K  +  +  +L+ ++  +    P D     ++ ++     S ++PL+ TY + M+YVY+S RKI+MV S+ GLAF++ FTVA++L M+ GIC ++ +   +  GSE++PY+ +I+GLENTL IT+S+V T   L V  RIA GL +EG+ ++K  I E+  L +G  T    IQEF   ++I ++ DF++Q+ F+   L+ D++R+ L + R      L   I         L  Y   S  +    W K     F    + K ++  S I    K  +++   I++    + DG V    P    R+  +YF  + RI QR +++V A+W +F++ +  S  L     L N     L     I  T      +W+      WP +A  Y+I++  R +  LP
Sbjct:    1 MNDRVKIRWKEAKERIGNAYHDYGRLCAAHPKACLSMSLLTMIVLSYPTITRLRLPVSTPIDVFWSEHLHVNDKIAPFWINENPASYIQQFIVSTTISPWNATEMGPEHAVRAAIATAFRIRQILLAEPAVEELCLRLAN-QRQDSSWPFRSKSLCVVLSPASIWYNNLQKFREDDDTITTVFNEHCKSTFCMRDLLLGAPIAATGIKQKYQTNRKRKIEFAVTMFFARYSKKVIQGIREKLQKEFELVDT-PPNDQRTFVQVYFHPLKTFSDYIPLISTYFVCMIYVYYSSRKIQMVASRWGLAFASSFTVASTLLMTTGICAHLDLSTTTW-GSEVYPYIALIMGLENTLCITRSVVYTSPSLDVSSRIAHGLSQEGYKLTKYYILELLALLIGFLTRISDIQEFCQFSVICVTVDFYMQLFFYAPCLTFDLQRLGLEEKRKFAEILLYEEIP-------RLKNYAPVSCPMRKI-WPK----LFVMKKMQKRRVSDSGIEDVMKNDEQRRLLISSEFDSKDDGDVQEPRPEDSVRMKIMYFITRTRIVQRTILVVFAIWTVFLVFFVGSRQLGMESNLTNQSIESLTRSHRILSTANLQYGNWQRRTYKWWPPVAHEYNISLNSRYVTFLP 619
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Celegans
Match: daf-6 (pep chromosome:WBcel235:X:14888488:14894297:1 gene:WBGene00000902.1 transcript:F31F6.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:daf-6)

HSP 1 Score: 62.3882 bits (150), Expect = 1.938e-9
Identity = 40/155 (25.81%), Postives = 79/155 (50.97%), Query Frame = 1 
Query:  841 SVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDC 1305
            S  KI+ + SK  LA +  F+   S+  + G    +G+    +  + I P+L++ IG+++  ++      T   L V  R+++ L   G A++   ++++   ++G  T  P IQ F + A + ++  +F Q+TFF   ++I M  +E  + R C
Sbjct:  291 SATKIDWISSKPWLAAAGMFSTVLSIISAFGFLFILGVRYNVI--NTIIPFLIIAIGIDDMFLMNACWDQTSKSLSVPERMSKTLSHAGVAVTITNVTDVMSFAIGCITDLPGIQFFCIYACVSVAFSYFYQLTFFSGAMAI-MGEVE-REKRHC 441
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Celegans
Match: ptr-16 (PaTched Related family [Source:UniProtKB/TrEMBL;Acc:A0A0K3ASC2])

HSP 1 Score: 61.2326 bits (147), Expect = 3.635e-9
Identity = 29/100 (29.00%), Postives = 56/100 (56.00%), Query Frame = 1 
Query:  982 IFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRM 1281
            + P+L++ +G ++  +I  ++  T     ++ RIA+ +E+ G +I+    +     ++GI T  PAI  F L   + ++ DF  Q+TFFV VL  + +R+
Sbjct:  232 VMPFLIIGVGCDDVFIIIHAMRKTDKSESLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRL 331
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Celegans
Match: ptr-16 (PaTched Related family [Source:UniProtKB/TrEMBL;Acc:A0A0K3ASC2])

HSP 1 Score: 61.2326 bits (147), Expect = 4.282e-9
Identity = 29/100 (29.00%), Postives = 56/100 (56.00%), Query Frame = 1 
Query:  982 IFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRM 1281
            + P+L++ +G ++  +I  ++  T     ++ RIA+ +E+ G +I+    +     ++GI T  PAI  F L   + ++ DF  Q+TFFV VL  + +R+
Sbjct:  325 VMPFLIIGVGCDDVFIIIHAMRKTDKSESLEDRIAETMEEAGPSITVTSATNCLSFAIGIATPTPAISLFCLYTCVAVAVDFVYQLTFFVAVLVYEEKRL 424
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Celegans
Match: ptr-18 (PaTched Related family [Source:UniProtKB/TrEMBL;Acc:Q9XWL9])

HSP 1 Score: 60.8474 bits (146), Expect = 6.163e-9
Identity = 44/145 (30.34%), Postives = 69/145 (47.59%), Query Frame = 1 
Query:  850 KIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRME 1284
            K + VKSK   AF        SL  S G   ++G     LP   + P+L++ IG+++  +   +   TP    V+ R+A+ L   G +IS   ++ +   ++GIFT  PAI  F +     +  D+  QI FF  VL +   R E
Sbjct:  284 KRDPVKSKPFEAFLGVICPILSLCASFGHLFWMGF--EYLPIVTVVPFLILSIGVDDVFIFIHAWHRTPYKHSVRDRMAETLADAGPSISITSLTNLLSFAIGIFTPTPAIYTFCVFISTAVIYDYIYQIFFFSAVLVLSGEREE 426
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Fly
Match: SCAP (gene:FBgn0033052 transcript:FBtr0086027)

HSP 1 Score: 237.654 bits (605), Expect = 1.078e-63
Identity = 187/628 (29.78%), Postives = 285/628 (45.38%), Query Frame = 1 
Query:   46 IEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNT---------------------SFHS--------------NTPFHQRKIFLNDLVN--------LYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEA-------CLETGDINLNDKSY--NLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTI------NSRKRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKY-----NNISVHEPTD------SGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHL--GKYNRDSFIIYLFRWIKDQS---MSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNLFHSVFLRNIISL 1707
            +   YY +G F +S+P    +     I++SCYPL+N                      S+HS                P+      LN             +++      YVQQI ++    L  ++    ++     L E FK++ EI   H   E        CL   ++          +FP + CL LSP  LW   +  F+ D NIL TI         K    EM FGLP   TG      + ++  I YA+T  LK  D  +LD+L  +L   Y      + S  EPT        GE  ++    Y        + ++++  YVYFSVRKI++ +S+  LA  +  T A SL MSLG+C + G+ + SL   +IFPYLV+++GLEN+LVITKS+V+      VK R+AQ L KEGW ISK L++EI IL++G+ TF P IQEF + A++GL +DF LQ+  F T+L+++++R E +         LL+        D+           F+   F+  + QS   + F +        +++++  GH                      IP+R+  + FWA+ R FQR  MI   VWI  I+      ++S +L  + S+
Sbjct:   59 VSHFYYKHGLFLSSYPTCASSIAFMAILLSCYPLINIPLPGTIPTKIVVPYETGSGSLSWHSLNTSSTTPQEPHPSGEPWPPEPQVLNSSTTDRSPPPLLPWAQSSPAFFYVQQITLRTSV-LPWTEGMQLMDAFRAPLHEVFKLL-EIVRNHQSSENKRTLEHNCLHVDNVKRGTHGQLDQIFPEYGCLLLSPANLWTQNSQNFTRDTNILNTIFQYHNLQKSKVSAAEMLFGLPMQDTGFKRYPLRARSRIIQYALTLFLKHNDMEYLDTLKEKLLRHYPPLPLASASAEEPTTITYIFYPGEYRMWELVPY-------TVAFMLVFAYVYFSVRKIDVFRSRFLLALCSVITTAGSLAMSLGLCFFFGLTI-SLQSKDIFPYLVILVGLENSLVITKSVVSMDETFDVKIRVAQALSKEGWHISKTLLTEITILTIGLATFVPVIQEFCIFAIVGLLSDFMLQMLLFSTILAMNIKRTEYTAEAKHLPKMLLSCTQGAGRQDFRFFGAAPALPPFVPGTFQ--RSQSHPKLCFADPASVS---DRTSLVNGHSSPEQR----------------IPKRIKIVNFWARTRFFQRAFMIWMIVWICSIV------YNSGYLEQLFSM 649
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Fly
Match: Npc1a (gene:FBgn0024320 transcript:FBtr0343610)

HSP 1 Score: 67.3958 bits (163), Expect = 7.525e-11
Identity = 48/154 (31.17%), Postives = 80/154 (51.95%), Query Frame = 1 
Query:  862 VKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGS----EIFPYLVVIIGLENT--LVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDC 1305
            + SK+ L       V AS+  S+G+  YIG     LP +    E+ P+LV+ +G++N   LV T        +  ++ ++ + L K G ++    +SE F   LG  +  PA++ F L A + L  DF LQIT FV++ ++D +R E + +  C
Sbjct:  648 IDSKITLGIGGVIIVLASVVSSVGVFGYIG-----LPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDIC 796
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Fly
Match: Npc1a (gene:FBgn0024320 transcript:FBtr0343609)

HSP 1 Score: 67.3958 bits (163), Expect = 7.525e-11
Identity = 48/154 (31.17%), Postives = 80/154 (51.95%), Query Frame = 1 
Query:  862 VKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGS----EIFPYLVVIIGLENT--LVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDC 1305
            + SK+ L       V AS+  S+G+  YIG     LP +    E+ P+LV+ +G++N   LV T        +  ++ ++ + L K G ++    +SE F   LG  +  PA++ F L A + L  DF LQIT FV++ ++D +R E + +  C
Sbjct:  648 IDSKITLGIGGVIIVLASVVSSVGVFGYIG-----LPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDIC 796
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Fly
Match: Npc1a (gene:FBgn0024320 transcript:FBtr0343608)

HSP 1 Score: 67.3958 bits (163), Expect = 7.525e-11
Identity = 48/154 (31.17%), Postives = 80/154 (51.95%), Query Frame = 1 
Query:  862 VKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGS----EIFPYLVVIIGLENT--LVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDC 1305
            + SK+ L       V AS+  S+G+  YIG     LP +    E+ P+LV+ +G++N   LV T        +  ++ ++ + L K G ++    +SE F   LG  +  PA++ F L A + L  DF LQIT FV++ ++D +R E + +  C
Sbjct:  648 IDSKITLGIGGVIIVLASVVSSVGVFGYIG-----LPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDIC 796
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Fly
Match: Npc1a (gene:FBgn0024320 transcript:FBtr0303907)

HSP 1 Score: 67.3958 bits (163), Expect = 7.791e-11
Identity = 48/154 (31.17%), Postives = 80/154 (51.95%), Query Frame = 1 
Query:  862 VKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGS----EIFPYLVVIIGLENT--LVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDC 1305
            + SK+ L       V AS+  S+G+  YIG     LP +    E+ P+LV+ +G++N   LV T        +  ++ ++ + L K G ++    +SE F   LG  +  PA++ F L A + L  DF LQIT FV++ ++D +R E + +  C
Sbjct:  652 IDSKITLGIGGVIIVLASVVSSVGVFGYIG-----LPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDIC 800
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Zebrafish
Match: scap (SREBF chaperone [Source:ZFIN;Acc:ZDB-GENE-040107-41])

HSP 1 Score: 283.493 bits (724), Expect = 1.268e-78
Identity = 170/450 (37.78%), Postives = 263/450 (58.44%), Query Frame = 1 
Query:   25 KNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPF-------------HQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLND------KSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI 1296
            +   R  I   +Y +G  CAS+P+ I+    + I+  CYPLL        P              H+ +  L++  + Y      + Y+QQ++V+       + +  P+++    L   F +++EI+  H Y +  LE   + + D      +   + P   CL +SP   W+ + D F +D ++LKT++  +         ++++ FG+P  +TG+S +++KK+   + Y +T  L  YD  F+ SL A+LK  + + +     D    + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MV+SK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FTF PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+
Sbjct:    4 RERLRQNISAAFYRHGLLCASYPVPIILFTSASILTCCYPLLKLPLPGTGPVEFTTGVRDYSIPSHESQGDLSERPDWYRGPP--VAYIQQVLVKAAVSPWGNSLV-PVDVFRSPLGRVFSLLDEIR-NHVYTDRSLEALCLQVTDLLPGLRRMQAVLPEHGCLLVSPGNYWQNRRDLFDADPDLLKTVHQHEPKGLHTSATLRDLLFGVPGKQTGVS-LYSKKR--VVTYTVTIALSSYDARFVGSLRARLKQLHPSANCTLREDHMVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVRSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWSIMKNMATELCIILIGYFTFVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL 445
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Zebrafish
Match: scap (SREBF chaperone [Source:ZFIN;Acc:ZDB-GENE-040107-41])

HSP 1 Score: 283.493 bits (724), Expect = 1.268e-78
Identity = 170/450 (37.78%), Postives = 263/450 (58.44%), Query Frame = 1 
Query:   25 KNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPF-------------HQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLND------KSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI 1296
            +   R  I   +Y +G  CAS+P+ I+    + I+  CYPLL        P              H+ +  L++  + Y      + Y+QQ++V+       + +  P+++    L   F +++EI+  H Y +  LE   + + D      +   + P   CL +SP   W+ + D F +D ++LKT++  +         ++++ FG+P  +TG+S +++KK+   + Y +T  L  YD  F+ SL A+LK  + + +     D    + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MV+SK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FTF PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+
Sbjct:    4 RERLRQNISAAFYRHGLLCASYPVPIILFTSASILTCCYPLLKLPLPGTGPVEFTTGVRDYSIPSHESQGDLSERPDWYRGPP--VAYIQQVLVKAAVSPWGNSLV-PVDVFRSPLGRVFSLLDEIR-NHVYTDRSLEALCLQVTDLLPGLRRMQAVLPEHGCLLVSPGNYWQNRRDLFDADPDLLKTVHQHEPKGLHTSATLRDLLFGVPGKQTGVS-LYSKKR--VVTYTVTIALSSYDARFVGSLRARLKQLHPSANCTLREDHMVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVRSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWSIMKNMATELCIILIGYFTFVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL 445
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Zebrafish
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161])

HSP 1 Score: 67.0106 bits (162), Expect = 1.276e-10
Identity = 53/171 (30.99%), Postives = 89/171 (52.05%), Query Frame = 1 
Query:  859 MVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLP---VKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDCYHNQLLNSINEESSLDW 1356
            +V SK+ L  +    V +S+  SLGI  YIGI + +L   E+ P+LV+ +G++N  +I ++       +P   +  +I + L     ++  +  SE     LG  +  PA++ F L A + +  DF LQI+ FV++L +D++R E +  DI  C     L+   EE S  W
Sbjct:  651 LVDSKISLGIAGILIVLSSVACSLGIFSYIGIPL-TLIVIEVIPFLVLAVGVDNIFIIVQTYQRDE-RMPEEELHQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVK---LSDGQEEKSEGW 816
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Zebrafish
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161])

HSP 1 Score: 67.0106 bits (162), Expect = 1.307e-10
Identity = 53/171 (30.99%), Postives = 89/171 (52.05%), Query Frame = 1 
Query:  859 MVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLP---VKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDCYHNQLLNSINEESSLDW 1356
            +V SK+ L  +    V +S+  SLGI  YIGI + +L   E+ P+LV+ +G++N  +I ++       +P   +  +I + L     ++  +  SE     LG  +  PA++ F L A + +  DF LQI+ FV++L +D++R E +  DI  C     L+   EE S  W
Sbjct:  646 LVDSKISLGIAGILIVLSSVACSLGIFSYIGIPL-TLIVIEVIPFLVLAVGVDNIFIIVQT-YQRDERMPEEELHQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVK---LSDGQEEKSEGW 811
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Zebrafish
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161])

HSP 1 Score: 67.0106 bits (162), Expect = 1.342e-10
Identity = 53/171 (30.99%), Postives = 89/171 (52.05%), Query Frame = 1 
Query:  859 MVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLP---VKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDCYHNQLLNSINEESSLDW 1356
            +V SK+ L  +    V +S+  SLGI  YIGI + +L   E+ P+LV+ +G++N  +I ++       +P   +  +I + L     ++  +  SE     LG  +  PA++ F L A + +  DF LQI+ FV++L +D++R E +  DI  C     L+   EE S  W
Sbjct:  651 LVDSKISLGIAGILIVLSSVACSLGIFSYIGIPL-TLIVIEVIPFLVLAVGVDNIFIIVQT-YQRDERMPEEELHQQIGRILGDVAPSMFLSSFSETVAFFLGALSTMPAVRTFSLFAGLAIFIDFLLQISCFVSLLGLDIKRQEANRMDILCCVK---LSDGQEEKSEGW 816
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Xenopus
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:100145201])

HSP 1 Score: 298.516 bits (763), Expect = 1.493e-83
Identity = 218/680 (32.06%), Postives = 345/680 (50.74%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSN------TPFHQRKIFLNDLVNLYSEDKKLIG----YVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK---FRHDYLEACLETGDINLND------KSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNLFHSVFLRNIISL------PL-----------------------QPDIHIDLT------DDWKLLAMHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITPKALVD 1884
            +  R +I + +Y++G  CAS+PI I+      I+ SCYPLL             TP         + +N ++  +  +G    Y+QQ++V+      + D    +++    LS  F +V EI+    R    E  LE   + + D      K  +  P   CL LSP   W+   + FS D ++++TI+  +         +K++ FG+P  ++G+S ++ +K+   ++YAIT  L +YD TFL+SL ++LK ++ + +   P+     + +  +  ++  +PL+ TY+IL  Y+YFS RKI++VKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+     N+ + +            +Y R   +    R     +++   + L   +L K                                RL  +YF+A+ R+ QR++M    VWI  I++Y+        LRN +++      PL                       +   H  +T      + W+ L+  HWP L   Y+I +  + + +LP   +   I +TP+ + D
Sbjct:    5 DKLRERISRAFYSHGLLCASYPIPIIILTALCILASCYPLLKLPLPGTGPVEYVTPVRDYSPPPLEPINTHNPIRTYVGLPVSYIQQVLVKAVVSPWDKDFLA-VDVFRSPLSRVFPLVEEIRNHVLREKSQEKSLEDVCLQVTDLLPGLKKLRDKLPEHGCLLLSPANFWQNSQEHFSGDPDLIRTIHQHEPKTLQTSATLKDLLFGVPGKQSGVS-LYNRKR--IVSYAITIALHRYDATFLNSLRSRLKQQHPSTNSSAPSQHIVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDLVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWFIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL-----NKRMPAEACMPPPKPGAKRYERQPAL----RPATPHTITLQPSSLRNLRLPK--------------------------------RLRLVYFFARTRLAQRIIMAGTVVWI-GILVYT----DPAGLRNYLTVQVTEQSPLGGAVMPPVPVPVLPASNPQTAGKEDKAHTQVTWGPEDEETWRKLSFRHWPTLFSYYNITLAKKYISILPMIPV--TIYLTPQEVSD 631
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Xenopus
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:100145201])

HSP 1 Score: 286.96 bits (733), Expect = 1.559e-79
Identity = 194/570 (34.04%), Postives = 300/570 (52.63%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSN------TPFHQRKIFLNDLVNLYSEDKK------LIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK---FRHDYLEACLETGDINLND------KSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
            +  R +I + +Y++G  CAS+PI I+      I+ SCYPLL             TP         +       D+        + Y+QQ++V+      + D    +++    LS  F +V EI+    R    E  LE   + + D      K  +  P   CL LSP   W+   + FS D ++++TI+  +         +K++ FG+P  ++G+S ++ +K+   ++YAIT  L +YD TFL+SL ++LK ++ + +   P+     + +  +  ++  +PL+ TY+IL  Y+YFS RKI++VKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+     N+ + +            +Y R   +    R     +++   + L   +L K                                RL  +YF+A+ R+ QR++M    VWI  ++
Sbjct:    5 DKLRERISRAFYSHGLLCASYPIPIIILTALCILASCYPLLKLPLPGTGPVEYVTPVRDYSPPPLEPSPEDHSDRPDWYVGLPVSYIQQVLVKAVVSPWDKDFLA-VDVFRSPLSRVFPLVEEIRNHVLREKSQEKSLEDVCLQVTDLLPGLKKLRDKLPEHGCLLLSPANFWQNSQEHFSGDPDLIRTIHQHEPKTLQTSATLKDLLFGVPGKQSGVS-LYNRKR--IVSYAITIALHRYDATFLNSLRSRLKQQHPSTNSSAPSQHIVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDLVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWFIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL-----NKRMPAEACMPPPKPGAKRYERQPAL----RPATPHTITLQPSSLRNLRLPK--------------------------------RLRLVYFFARTRLAQRIIMAGTVVWIGILV 528
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Xenopus
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:100145201])

HSP 1 Score: 286.574 bits (732), Expect = 2.044e-79
Identity = 194/570 (34.04%), Postives = 300/570 (52.63%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSN------TPFHQRKIFLNDLVNLYSEDKK------LIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK---FRHDYLEACLETGDINLND------KSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
            +  R +I + +Y++G  CAS+PI I+      I+ SCYPLL             TP         +       D+        + Y+QQ++V+      + D    +++    LS  F +V EI+    R    E  LE   + + D      K  +  P   CL LSP   W+   + FS D ++++TI+  +         +K++ FG+P  ++G+S ++ +K+   ++YAIT  L +YD TFL+SL ++LK ++ + +   P+     + +  +  ++  +PL+ TY+IL  Y+YFS RKI++VKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+     N+ + +            +Y R   +    R     +++   + L   +L K                                RL  +YF+A+ R+ QR++M    VWI  ++
Sbjct:    5 DKLRERISRAFYSHGLLCASYPIPIIILTALCILASCYPLLKLPLPGTGPVEYVTPVRDYSPPPLEPSPEDHSDRPDWYVGLPVSYIQQVLVKAVVSPWDKDFLA-VDVFRSPLSRVFPLVEEIRNHVLREKSQEKSLEDVCLQVTDLLPGLKKLRDKLPEHGCLLLSPANFWQNSQEHFSGDPDLIRTIHQHEPKTLQTSATLKDLLFGVPGKQSGVS-LYNRKR--IVSYAITIALHRYDATFLNSLRSRLKQQHPSTNSSAPSQHIVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDLVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWFIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL-----NKRMPAEACMPPPKPGAKRYERQPAL----RPATPHTITLQPSSLRNLRLPK--------------------------------RLRLVYFFARTRLAQRIIMAGTVVWIGILV 528
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Xenopus
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:100145201])

HSP 1 Score: 285.804 bits (730), Expect = 4.416e-79
Identity = 194/570 (34.04%), Postives = 300/570 (52.63%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSN------TPFHQRKIFLNDLVNLYSEDKK------LIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK---FRHDYLEACLETGDINLND------KSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
            +  R +I + +Y++G  CAS+PI I+      I+ SCYPLL             TP         +       D+        + Y+QQ++V+      + D    +++    LS  F +V EI+    R    E  LE   + + D      K  +  P   CL LSP   W+   + FS D ++++TI+  +         +K++ FG+P  ++G+S ++ +K+   ++YAIT  L +YD TFL+SL ++LK ++ + +   P+     + +  +  ++  +PL+ TY+IL  Y+YFS RKI++VKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+     N+ + +            +Y R   +    R     +++   + L   +L K                                RL  +YF+A+ R+ QR++M    VWI  ++
Sbjct:    5 DKLRERISRAFYSHGLLCASYPIPIIILTALCILASCYPLLKLPLPGTGPVEYVTPVRDYSPPPLEPSPEDHSDRPDWYVGLPVSYIQQVLVKAVVSPWDKDFLA-VDVFRSPLSRVFPLVEEIRNHVLREKSQEKSLEDVCLQVTDLLPGLKKLRDKLPEHGCLLLSPANFWQNSQEHFSGDPDLIRTIHQHEPKTLQTSATLKDLLFGVPGKQSGVS-LYNRKR--IVSYAITIALHRYDATFLNSLRSRLKQQHPSTNSSAPSQHIVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDLVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWFIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL-----NKRMPAEACMPPPKPGAKRYERQPAL----RPATPHTITLQPSSLRNLRLPK--------------------------------RLRLVYFFARTRLAQRIIMAGTVVWIGILV 528
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Xenopus
Match: fosl1 (FOS-like antigen 1 [Source:Xenbase;Acc:XB-GENE-6257957])

HSP 1 Score: 65.4698 bits (158), Expect = 5.528e-10
Identity = 45/144 (31.25%), Postives = 77/144 (53.47%), Query Frame = 1 
Query:  859 MVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPV--DLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRME 1284
            +V SK+ L  +    V +S+  SLGI  Y G+ + +L   E+ P+LV+ +G++N  +I +         D  +  +I + L     +I  +  +E     LG  +  PA++ F L A + +  DF LQIT F+++LS+D+RR E
Sbjct:  658 LVDSKISLGIAGILIVLSSVACSLGIFSYAGVSL-TLIVIEVIPFLVLAVGVDNIYIIVQRYQRDERLHDETLDQQIGRILGDVAPSIFLSAFAETVAFFLGALSSMPAVRTFSLFAGMAVFLDFLLQITCFISLLSLDIRRQE 800
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Mouse
Match: Scap (SREBF chaperone [Source:MGI Symbol;Acc:MGI:2135958])

HSP 1 Score: 278.87 bits (712), Expect = 5.117e-77
Identity = 203/589 (34.47%), Postives = 295/589 (50.08%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYS-----EDKKL--------------IGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK--------FRHDYLEACLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQL-----------KAKYNNISVHEPTDSG-EELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
               R KI + +YN+G  CAS+PI I+      I+  CYPLL        P     +  +  V  YS      D K               + Y+QQI V++       ++   +++    LS  F++V EI+              E CL+  D+     K  +L P   CL LSP   W+   ++F +D +I+ TI+  +         +K++ FG+P   +G+S ++T+K+   ++Y IT + ++Y   FL SL A+L           +A+ N + VH   + G  EL+    TY+           IL  Y+YFS RKI+MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN  +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+           +  ES L                       +   G    + E+ +    S  H            +Q      + +P+RL  +YF A+ R+ QRL+M    VWI  ++
Sbjct:    5 ERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGP-----VEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLA-VDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVS-LYTRKR--MVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAE-NLVHVHFKEEIGIAELIPLVTTYI-----------ILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNAATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN--------KRLPPESCL---------------------PSAKPVGRPARY-ERQQAVRPSTPH---------TITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILV 532
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Mouse
Match: Ptch2 (patched 2 [Source:MGI Symbol;Acc:MGI:1095405])

HSP 1 Score: 60.8474 bits (146), Expect = 1.143e-8
Identity = 33/155 (21.29%), Postives = 75/155 (48.39%), Query Frame = 1 
Query:  856 EMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDCYHN 1314
            +  +S+  +  +    VA ++   LG+C  +GI   +   +++ P+L + IG+++  ++  +    P D P+  R+ + L   G +++   ++ +    +      PA++ F L A I +  +F   +  F  +LS+D+RR      D+  C+ +
Sbjct:  417 DCAQSQGAVGLAGVLLVALAVASGLGLCALLGITF-NAATTQVLPFLALGIGVDDIFLLAHAFTKAPPDTPLPERMGECLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCFSS 570
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Mouse
Match: Npc1 (NPC intracellular cholesterol transporter 1 [Source:MGI Symbol;Acc:MGI:1097712])

HSP 1 Score: 59.6918 bits (143), Expect = 2.453e-8
Identity = 50/188 (26.60%), Postives = 93/188 (49.47%), Query Frame = 1 
Query:  859 MVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATP--VDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKD 1416
            +V SK+ L  +    V +S+  SLGI  Y+G+ + +L   E+ P+LV+ +G++N  ++ ++        +  +  ++ + L +    +  +  SE      G  +  PA+  F L A + +  DF LQIT FV++L +D++R E +      H  +L  +      D   G +  +S   YLFR+ K+
Sbjct:  649 LVDSKISLGIAGILIVLSSVACSLGIFSYMGMPL-TLIVIEVIPFLVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAVHTFSLFAGMAVLIDFLLQITCFVSLLGLDIKRQEKN------HLDILCCVR---GADDGQGSHASES---YLFRFFKN 823
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Mouse
Match: Ptch1 (patched 1 [Source:MGI Symbol;Acc:MGI:105373])

HSP 1 Score: 54.299 bits (129), Expect = 8.929e-7
Identity = 36/160 (22.50%), Postives = 80/160 (50.00%), Query Frame = 1 
Query:  865 KSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVD--LPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDCYHNQLLNSI 1332
            KS+  +  +    VA S+   LG+C  IGI   +   +++ P+L + +G+++  ++  +   T  +  +P + R  + L++ G +++   IS +    +      PA++ F L A + +  +F + +  F  +LS+D+ R E    DI  C+ +  ++ +
Sbjct:  398 KSQGAVGLAGVLLVALSVAAGLGLCSLIGISF-NAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRV 556
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Mouse
Match: Ptch1 (patched 1 [Source:MGI Symbol;Acc:MGI:105373])

HSP 1 Score: 54.6842 bits (130), Expect = 9.002e-7
Identity = 36/160 (22.50%), Postives = 80/160 (50.00%), Query Frame = 1 
Query:  865 KSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVD--LPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDCYHNQLLNSI 1332
            KS+  +  +    VA S+   LG+C  IGI   +   +++ P+L + +G+++  ++  +   T  +  +P + R  + L++ G +++   IS +    +      PA++ F L A + +  +F + +  F  +LS+D+ R E    DI  C+ +  ++ +
Sbjct:  450 KSQGAVGLAGVLLVALSVAAGLGLCSLIGISF-NAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRV 608
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. UniProt/SwissProt
Match: sp|A6QM06|SCAP_BOVIN (Sterol regulatory element-binding protein cleavage-activating protein OS=Bos taurus OX=9913 GN=SCAP PE=2 SV=1)

HSP 1 Score: 284.263 bits (726), Expect = 6.170e-78
Identity = 197/572 (34.44%), Postives = 295/572 (51.57%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKL--------------IGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK--------FRHDYLEACLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
               R KI + +YN+G FCAS+PI I+      I+  CYPLL        P        +      + D K               + Y+QQI V++       ++   +++    LS  F++V EI+              + CL+  D+     K  NL P   CL LSP   W+   ++F +D +I++TI+  +         +K++ FG+P   +G+S ++T+K+   ++Y IT + + Y   FL SL A+L   + + +     +S   + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+           +  E+ L                       +   G    F E+      S  H            +Q      + +P+RL  +YF A+ R+ QRL+M    VWI  ++
Sbjct:    5 ERLREKISQAFYNHGLFCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFTTPVKDYSPPPLTSDHKPGEPNEQPEWYVGAPVAYIQQIFVKSSVSPWHKNLLA-VDVFRSPLSRAFQLVEEIRNHVLKDSSGTRSLEDVCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQNDRERFHADPDIIRTIHQHEPKTLQTSATLKDLLFGVPGKYSGVS-LYTRKR--LVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIVLIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN--------KRLPPEACL---------------------PPAKPVGRPTRF-ERQPTVRPSMPH---------TITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILV 532
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. UniProt/SwissProt
Match: sp|Q5MNU5|SCAP_PIG (Sterol regulatory element-binding protein cleavage-activating protein OS=Sus scrofa OX=9823 GN=SCAP PE=2 SV=2)

HSP 1 Score: 283.878 bits (725), Expect = 7.404e-78
Identity = 196/568 (34.51%), Postives = 294/568 (51.76%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKL--------------IGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK--------FRHDYLEACLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWI 1641
               R KI + +YN+G  CAS+PI I+      I+  CYPLL        P        +      + D K               + Y+QQI V++       ++   +++    LS  F++V EI+              E CL+  D+     K  N+ P   CL LSP   W+   ++F +D +I+ TI+  +         +K++ FG+P   +G+S ++T+K+   ++Y IT + + Y   FL SL A+L   + + +     +S   + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+           +  E+ L                       +   G +  F+ +L          R A+       +Q      + +P+RL  +YF A+ R+ QRL+M    VWI
Sbjct:    5 ERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFTTPVKDYSPPPSASDHKPGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHKNLLA-VDVFRSPLSRAFQLVEEIRNHVLRDSSGTRSLEEVCLQVTDLLPGLRKLRNILPEHGCLLLSPGNFWQNDRERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKHSGVS-LYTRKR--LVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMPFFTTVLSIDIRRMELADLN--------KRLPPEACL---------------------PPAKPVGRSARFERQLA--------VRPATPHTIT--LQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWI 528
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. UniProt/SwissProt
Match: sp|Q12770|SCAP_HUMAN (Sterol regulatory element-binding protein cleavage-activating protein OS=Homo sapiens OX=9606 GN=SCAP PE=1 SV=4)

HSP 1 Score: 282.722 bits (722), Expect = 2.072e-77
Identity = 199/577 (34.49%), Postives = 297/577 (51.47%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKL--------------IGYVQQIIVQN-----HAELVESDINNPIEIVYEALSECFKIVNEIKFR--------HDYLEACLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
               R KI + +YN+G  CAS+PI I+      I+  CYPLL        P        +        D+K               + YVQQI V++     H  L+       +++    LS  F++V EI+              E CL+  D+     K  NL P   CL LSP   W+   ++F +D +I+ TI+  +         +K++ FG+P   +G+S ++T+K+   ++Y IT + + Y   FL SL A+L   + + +     +S   + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+           +  E+ L                       +   G    ++ +L           + S  +T   +Q      + +P+RL  +YF A+ R+ QRL+M    VWI  ++
Sbjct:    5 ERLREKISRAFYNHGLLCASYPIPIILFTGFCILACCYPLLKLPLPGTGPVEFTTPVKDYSPPPVDSDRKQGEPTEQPEWYVGAPVAYVQQIFVKSSVFPWHKNLLA------VDVFRSPLSRAFQLVEEIRNHVLRDSSGIRSLEELCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVS-LYTRKR--MVSYTITLVFQHYHAKFLGSLRARLMLLHPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN--------KRLPPEACL---------------------PSAKPVGQPTRYERQLAV---------RPSTPHTIT-LQPSSFRNLRLPKRLRVVYFLARTRLAQRLIMAGTVVWIGILV 532
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. UniProt/SwissProt
Match: sp|A2RRU4|SCAP_RAT (Sterol regulatory element-binding protein cleavage-activating protein OS=Rattus norvegicus OX=10116 GN=Scap PE=2 SV=1)

HSP 1 Score: 280.796 bits (717), Expect = 8.389e-77
Identity = 203/589 (34.47%), Postives = 298/589 (50.59%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYS-----EDKKL--------------IGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK--------FRHDYLEACLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQL-----------KAKYNNISVHEPTDSG-EELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
               R KI + +YN+G  CAS+PI I+      I+  CYPLL        P     +  +  V  YS      D K               + Y+QQI V++       ++   +++    LS  F++V EI+              E CL+  D+     K  +L P   CL LSP   W+   ++F +D +I+ TI+  +         +K++ FG+P   +G+S ++T+K+   ++Y IT + ++Y   FL SL A+L           +A+ N + VH   + G  EL+    TY+           IL  Y+YFS RKI+MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+           +  ES L                       +   G    ++ +L           + S  +T   +Q      + +P+RL  +YF A+ R+ QRL+M    VWI  ++
Sbjct:    5 ERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGP-----VEFSTPVKGYSPPPADSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHRNLLA-VDVFRSPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVS-LYTRKR--MVSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAE-NLVHVHFKEEIGIAELIPLVTTYI-----------ILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLN--------KRLPPESCL---------------------PSAKPVGRPARYERQLAV---------RPSTPHTIT-LQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILV 532
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. UniProt/SwissProt
Match: sp|P97260|SCAP_CRIGR (Sterol regulatory element-binding protein cleavage-activating protein OS=Cricetulus griseus OX=10029 GN=SCAP PE=1 SV=1)

HSP 1 Score: 280.411 bits (716), Expect = 1.028e-76
Identity = 201/584 (34.42%), Postives = 296/584 (50.68%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTP---------FHQRKIFLNDLVNLYSEDKK-----LIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK--------FRHDYLEACLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQL-----------KAKYNNISVHEPTDSG-EELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
               R KI + +YN+G  CAS+PI I+      I+  CYPLL        P         +    +  +      SE  +      + Y+QQI V++       ++   +++    LS  F++V EI+              E CL+  D+     K  NL P   CL LSP   W+   ++F +D +I+ TI+  +         +K++ FG+P   +G+S ++T+K+   ++Y IT + ++Y   FL SL A+L           +A+ N + VH   + G  EL+    TY+           IL  Y+YFS RKI+MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+           +  ES L                       +   G    ++ +L          R A  +     +Q      + +P+RL  +YF A+ R+ QRL+M    VWI  ++
Sbjct:    5 ERLREKISQAFYNHGLLCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKDYSPPPVDSDHKQGEPSEQPEWYVGAPVAYIQQIFVKSSVSPWHKNLLA-VDVFRLPLSRAFQLVEEIRNHVLRDSSGTKSLEEVCLQVTDLLPGLRKLRNLLPEHGCLLLSPGNFWQNDWERFHADPDIIGTIHQHEPKTLQTSATLKDLLFGVPGKYSGVS-LYTRKRT--VSYTITLVFQRYHAKFLSSLRARLMLLHPSPNCSLRAE-NLVHVHFKEEIGIAELIPLVTTYI-----------ILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNVATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADLN--------KRLPPESCL---------------------PSAKPVGRPARYERQLA--------VRPA--MPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIMAGTVVWIGILV 532
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. TrEMBL
Match: A0A0L8I2Z2 (SSD domain-containing protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22036954mg PE=4 SV=1)

HSP 1 Score: 339.732 bits (870), Expect = 3.289e-98
Identity = 245/683 (35.87%), Postives = 369/683 (54.03%), Query Frame = 1 
Query:   43 KIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFH----------QRKIFLNDL-VNLYSEDKKL---------IGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIK-FRHD-------YLEACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSR-------KRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSG----EELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI-RDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKS-NISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNLFHSVFLRNIISL--------------------PLQPDI----HIDLTDDWKLLAMHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITP-KALVDKDP 1893
            +I  +YYNYG FCASH   I+  V+ ++II+CYPL       N P            QR++  +    +L+ +D K+          GY+QQI+ +   +        P +     LS+ F +V E+  F++          + CL   +   +   Y   P+FSCL LSP  LW   +++F SD+  +KT+  +          I+++ FG+PW +TG+   + + +   I++A+T + K Y++ F +SL   L+       +H   +S       + +    Y   + PL++TYL+L+LY+YFSVRKIEMVKSK GLA SA  TV ASL MS+ IC   G+   +L G EIFPYLVVIIGLEN L++TKS+V+TPV L VK+R+AQGL KEGW+I+KNL +E+ I+ +G FTF PAIQEF L A++GL TDFFLQ+ FF TVLS+D+RRMELSD+ +   H+ +  S NE SS  +   + +  S +++L      +SM        K++ EK  N+       +       F  S  ++   +PRRL  L+F A+ RI QR++M+   +WI+ +ILY   L     + +II+L                        D     H DL + W+ L+  H+P L   Y+I+I  R + +LP+ +L     ITP +A+  + P
Sbjct:    6 RIALIYYNYGLFCASHSYSIIGSVLFIVIIACYPLTKVPLPGNAPLEYTIPIQNFLEQRQMTSHGKDYSLHGKDLKVPPRWYTGSPFGYIQQILFKGTVKPWFPKKMIPSDAFRGPLSKVFDVVEELNLFKYSNNGTDFSLPDLCLHISEPVTSKSLYQYLPSFSCLILSPANLWNSDSNQFKSDDKFIKTVTQKFGQPLDTPPTIQDILFGVPWKETGVKRFYIRNRQRIISFAVTIIFKSYNQKFHESLRHTLEKTLPG-RIHNANNSAINHIVHIYFKDINYFVEYTPLMVTYLVLLLYIYFSVRKIEMVKSKWGLALSAVATVIASLLMSVSICTMFGLTT-TLNGGEIFPYLVVIIGLENVLILTKSVVSTPVHLEVKYRVAQGLSKEGWSITKNLTTELLIILVGFFTFVPAIQEFCLFAVVGLLTDFFLQMVFFATVLSVDIRRMELSDLQKQNIHSSI--SGNEGSSNTYPPRESSFHSPVMFL---QDTRSMP-------KQQKEKQVNVPNNDPSPSFAQMRDEFFNSPTILE--LPRRLQILFFLARTRIVQRVIMMGTVIWII-LILYKAGLIGYSLVDSIIALVYGGLFKNSSSHQNEERLMGKYDDDAGSVEHKDL-EMWRKLSYKHFPTLFGYYNISIYGRFVSILPTIHL--SAIITPEEAIQSRHP 668
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. TrEMBL
Match: A0A0L8I305 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22036954mg PE=4 SV=1)

HSP 1 Score: 338.576 bits (867), Expect = 6.148e-96
Identity = 245/683 (35.87%), Postives = 370/683 (54.17%), Query Frame = 1 
Query:   43 KIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFH----------QRKIFLNDL-VNLYSEDKKL---------IGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEI---KFRHDYLE-----ACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSR-------KRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSG----EELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI-RDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKS-NISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNLFHSVFLRNIISL--------------------PLQPDI----HIDLTDDWKLLAMHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITP-KALVDKDP 1893
            +I  +YYNYG FCASH   I+  V+ ++II+CYPL       N P            QR++  +    +L+ +D K+          GY+QQI+ +   +        P +     LS+ F +V E+   K+ ++  +      CL   +   +   Y   P+FSCL LSP  LW   +++F SD+  +KT+  +          I+++ FG+PW +TG+   + + +   I++A+T + K Y++ F +SL   L+       +H   +S       + +    Y   + PL++TYL+L+LY+YFSVRKIEMVKSK GLA SA  TV ASL MS+ IC   G+   +L G EIFPYLVVIIGLEN L++TKS+V+TPV L VK+R+AQGL KEGW+I+KNL +E+ I+ +G FTF PAIQEF L A++GL TDFFLQ+ FF TVLS+D+RRMELSD+ +   H+ +  S NE SS  +   + +  S +++L      +SM        K++ EK  N+       +       F  S  ++   +PRRL  L+F A+ RI QR++M+   +WI+ +ILY   L     + +II+L                        D     H DL + W+ L+  H+P L   Y+I+I  R + +LP+ +L     ITP +A+  + P
Sbjct:    6 RIALIYYNYGLFCASHSYSIIGSVLFIVIIACYPLTKVPLPGNAPLEYTIPIQNFLEQRQMTSHGKDYSLHGKDLKVPPRWYTGSPFGYIQQILFKGTVKPWFPKKMIPSDAFRGPLSKVFDVVEELNLFKYSNNGTDFSLPDLCLHISEPVTSKSLYQYLPSFSCLILSPANLWNSDSNQFKSDDKFIKTVTQKFGQPLDTPPTIQDILFGVPWKETGVKRFYIRNRQRIISFAVTIIFKSYNQKFHESLRHTLEKTLPG-RIHNANNSAINHIVHIYFKDINYFVEYTPLMVTYLVLLLYIYFSVRKIEMVKSKWGLALSAVATVIASLLMSVSICTMFGLTT-TLNGGEIFPYLVVIIGLENVLILTKSVVSTPVHLEVKYRVAQGLSKEGWSITKNLTTELLIILVGFFTFVPAIQEFCLFAVVGLLTDFFLQMVFFATVLSVDIRRMELSDLQKQNIHSSI--SGNEGSSNTYPPRESSFHSPVMFL---QDTRSMP-------KQQKEKQVNVPNNDPSPSFAQMRDEFFNSPTILE--LPRRLQILFFLARTRIVQRVIMMGTVIWII-LILYKAGLIGYSLVDSIIALVYGGLFKNSSSHQNEERLMGKYDDDAGSVEHKDL-EMWRKLSYKHFPTLFGYYNISIYGRFVSILPTIHL--SAIITPEEAIQSRHP 668
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. TrEMBL
Match: V4AN66 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_239368 PE=4 SV=1)

HSP 1 Score: 344.354 bits (882), Expect = 2.103e-95
Identity = 224/589 (38.03%), Postives = 326/589 (55.35%), Query Frame = 1 
Query:   10 KLPQNKNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVN------LYSEDKKLI----------GYVQQIIVQ------NHAELVESD-INNPIEIVYEALSECFKIVNEIKFRH-DYLEACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSR-------KRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELL---YNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNIS-KGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNL 1671
            KL   K+  +  I ++YY +G FCASHP  I+ GVI  ++I CYPL N     N P           V       + S ++ L           GY+QQI+V+        ++L  +D I  P+ +V++ L        E++       + CL   ++    K   + P +SCL LSP  LW+ + ++F++D +ILKTI  R          +K++ FG+PW  TGIS  F++ K   I +AIT + KKYD +F  +L  +L++ +   S +      + ++   Y    Y++ +  L + Y    LY+YFS +KIEMVKSK GLA SA   V ASL +S+ IC   G+  P L GSEIFPYLV+IIG+EN +V+TKSIV+TPV L VK R+AQGL KEGW I+KNL  E+ I+ +G+FT+ PAIQEF L A++G+ +DF LQ+ FFVTVLS+D+RRMEL+D+   +  ++L S+ E  +       Y+       +   IK  S +     +    L+  N+S K      S      F  S  ++   +PRRL FLYFWAK R+FQR++M    VWI+ +I Y T L
Sbjct:   28 KLKPYKDGIKSCISQIYYTHGLFCASHPYSIITGVIITVMIICYPLANRPHPGNAPVKYTTPLSGYTVPPRVQPLVKSSERHLSYPRWYVGKPEGYIQQIVVKATVSPWKPSKLTLTDSIRAPVSLVFQILDAVNNFQTEVRGEELSVADICLRVSEVVTKGKVKGMLPEYSCLILSPANLWQNQENRFTNDGDILKTIYRRYGQALETPPNLKDLLFGVPWGNTGISRYFSRTKERPIMFAITIITKKYDPSFTQTLRMKLESLFPETSENVNNTEKQHIVHFHYKDIDYVAEYTYLFVAYFAGFLYLYFSAKKIEMVKSKWGLAVSAVAMVIASLLVSVSICTLFGM-RPQLNGSEIFPYLVIIIGVENVVVLTKSIVSTPVHLDVKIRVAQGLSKEGWYITKNLFLELVIILIGLFTYVPAIQEFCLFAVVGILSDFCLQVFFFVTVLSVDIRRMELTDL---HKQRVLQSVKENDAAVQIEPLYH-----CPVAGHIKSSSKTHSAKSVPNLDLKDMNLSGKSITPPPSPGADDTFFPSPAILE--LPRRLKFLYFWAKTRMFQRMIMFCTFVWIV-LIFYKTGL 604
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. TrEMBL
Match: A0A2C9JN45 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106060767 PE=4 SV=1)

HSP 1 Score: 340.117 bits (871), Expect = 2.282e-94
Identity = 245/703 (34.85%), Postives = 380/703 (54.05%), Query Frame = 1 
Query:   43 KIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQR--KIFLNDLVNLYSED--------KKLIG----YVQQIIVQNHAE-----LVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSY------------NLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSR-------KRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQ----TYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLF----RWIKDQSMSF---GNNYLFKEKLEKSNISKGHKRKASDINTAAF-IQSDGMVPVY-IPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYS---------TNLFHSVF--------------LRNIISLP------------LQPDIHIDLTDDWKLLAMHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITPKALVDKDP 1893
            ++ ++YY YG FCASHP+  +  VI  + I+CYPL+N     N P   R  K     L+ L+S+D        + L+G    Y+QQI+V++        ++ SD           L+  FKIV+E++    Y++   E   ++L D  Y             L P +SCL +SP   W     K++ D +ILKT+  +           K++ FGLPW +TGI+  + + +   I+YA+T +L+KYD  F+ +L   L+  + + ++H   +S  E + +       Y+  + PLL+TYL+L+LY+YFSV KI+MVKSK+GLA SA  TV ASL MS+ IC   G+  P+L G EIFPYL VI+G+EN LVITKS+V+TPV L VK R+AQGL KEGW+I+KNL++E+ I+ +G FTF PAIQEF   AL+GL +DF+LQ+ FF TVLS+D+RRMELSD+   +   +  S+ + S++ +     N    ++         +  +S S      + +F    ++ +I+          + A +  ++    P Y +PRR+ F YF A+ RI Q+L+M+   +WI+ I   +         TN     F              LR+   +P            + P IH DL + W+ L+  HWP L   Y+I+++ R + +LP+ + L++I    KA++ + P
Sbjct:   10 RVAQIYYTYGLFCASHPLATIISVILSVFITCYPLINLPLPGNRPIEHRTPKAGFVPLLGLHSQDGMHDERKPRWLVGEPVAYIQQIVVKSTVSPWPQTMIASDA------FRAPLASVFKIVSELE-NFKYMDGSKE---VSLADNCYRISEPLKARHLQGLLPDYSCLLISPANFWNQDITKYNKDPDILKTMYRKFGQVVESPPSTKDLLFGLPWSQTGITRYYVRNRQRIISYAVTIVLRKYDAGFISALSKMLEEHHPD-TLHNVNNSAIEDIVHVHFKDVNYIIEYTPLLVTYLVLLLYLYFSVCKIDMVKSKIGLAISAVVTVLASLLMSVSICTLFGM-TPTLNGGEIFPYLAVIVGVENVLVITKSVVSTPVHLDVKIRVAQGLSKEGWSITKNLVTELAIVLVGFFTFVPAIQEFCAFALVGLLSDFYLQMAFFATVLSVDIRRMELSDL---HRQSVQQSVQDYSNMPY----VNIQPLVLCPVASRQTHVPPRSHSVPPPDPSSVFPPVRQQGHITPPPSPSLPTASNAHYRPETSSDRPKYEMPRRVKFFYFLARFRIVQKLIMVFTVIWIILIFYKAGLVVLTGDDTNTTFRTFSSRHNSDIRTGMDPLRSDDEIPYLSGKFLKDDEEVGPVIHTDL-ELWRRLSTKHWPLLFHYYNISLSGRYISLLPTIH-LSEIIDPKKAIMMRHP 691
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. TrEMBL
Match: A0A4E0RPI7 (Sterol regulatory element-binding protein cleavage-activating protein OS=Fasciola hepatica OX=6192 GN=D915_006535 PE=4 SV=1)

HSP 1 Score: 338.576 bits (867), Expect = 4.126e-93
Identity = 235/655 (35.88%), Postives = 350/655 (53.44%), Query Frame = 1 
Query:   34 FRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFH-------QRKIFLN-DLVNLYSEDKKLIGYVQQIIVQNHAELVESD---INNPIEIVYEALSECFKIVNEIK-FRHDYLEA----------CLETGDINL-----NDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRKRF--IKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYN------NISVHEP-TDSGEE--------------------------------------------LLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHN-------QLLNSINEESSLDWHL---------GKYNRDS---------FIIYLFRWIKDQSMS----FGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNL 1671
             R KI ++YYN+G FCA+HP  ++  V  +++  CYPL      ++ P         + + F N  L   Y    K +GY+QQI++  H+ +  S      +  + V  AL + FK+V  I+ FR +  E           C +  D  +     +D  YN  PTF CL L+P  LW+   ++F S +  L T   +     ++++FFG  W  TGI+      +   I++AIT +L++Y   F++ L   L + +       N S  +P T  GE+                                            + Y  ++YLS + PL++ YL+L+LY+YFSVRK+EMVKSKLGLAFSACFTV ASL+MS+G+CI IG++VP+L GSEIFPYLVV+IG EN +++TKS+VATP+DLPVK+RIAQGL KE W ++K+ +++  +L LG FTF+P +QEF L A++G++TDFFLQ+ FFV+VLSID+RRMELSD+   Y +       QL+ + N  +SL             G Y   S          +  L R +K +  +     G    +          +GHKRK S    AAF+ SD       PRRL  L  WAK+R+ QR +++  ++W+L  ++Y+ ++
Sbjct:    9 LRCKISRIYYNHGLFCATHPTQVIIFVCLIVLFLCYPLSQIPIVNDVPLDHFTLKEDEFRAFENAHLFVSYGNPNKSLGYMQQIVL--HSIVTPSSGFACFSTRKPVLRALEQSFKLVQLIREFRMNSTEPDSVGPSFEDLCFQVEDRAIFEDGASDTIYNALPTFGCLLLAPSLLWD-NLEQFWSQQATLFTRLKQASVGNLRDLFFGFMWKMTGITRYPICARETTISFAITLVLREYQPQFINQLRDHLLSHFAPKQFSANSSAEKPSTRPGEQPSPSDRVDFIPTDQVALDQLRETHFGDTPWTRADRLIGARHVYLVWYRMRSYLSDYAPLILIYLVLLLYIYFSVRKLEMVKSKLGLAFSACFTVVASLFMSIGLCINIGLMVPTLNGSEIFPYLVVLIGFENVVILTKSVVATPIDLPVKYRIAQGLSKESWPLTKHYVTQFVLLGLGFFTFHPTMQEFCLFAVVGVTTDFFLQLFFFVSVLSIDIRRMELSDLSTQYPSSSLVRDPQLMFAPNLITSLSTEQPNPMTIVRSGPYTTSSVWKFPTLWHLMTTLMRRLKLELTALCSRLGRLTPWSHFKTDPPFRRGHKRKVSAAEAAAFLASDERPTENFPRRLRILRMWAKHRLIQRFILVFMSLWLLIFLIYAVDI 660
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Cavefish
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:111190066])

HSP 1 Score: 293.508 bits (750), Expect = 4.090e-82
Identity = 193/569 (33.92%), Postives = 299/569 (52.55%), Query Frame = 1 
Query:   25 KNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPF-------------HQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLND------KSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFII 1653
            +   R  I   +Y +G  CAS+P+ I+    + I+  CYPLL        P              H+ +  L +  + Y      + Y+QQ++V+      +S +  P+++    L   F ++ EI+  H Y +  LET  + + +      +  ++ P   CL +SP   W+ + D F SD +ILKT++  +         +K++ FG+P   TG+S ++++K+   + Y IT  L  YD  F+ SL ++LK  + +++     D    + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MVKSK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+                         NR        R   +  M           L         +  A  I     +Q+     + +P+RL  +YF A+ R+ QR++M+   +WI  ++
Sbjct:    4 RERLRQNISAAFYRHGLLCASYPVPIILFTSASILTCCYPLLKLPLPGTGPVEFTTGVKDYSVPSHEPQGDLGERPDWYRGPP--VAYIQQVLVKAAVSPWDSSLV-PVDVFRSPLGRVFSLLEEIR-NHVYTDRSLETLCLQVTELLPGLRRMQSILPEHGCLLVSPGNYWQNRRDLFDSDPDILKTVHQHEPKGIHTSATLKDLLFGVPGKNTGVS-LYSRKR--VVTYTITIALSNYDSRFVASLRSRLKQLHPSVNCTLREDHMVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVKSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSSESWSIMKNMATELVIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL-------------------------NR--------RLPAEAGMPP---PPKPGPLRTREAPPPPRPSAHTIT----LQAPAFRNLRLPKRLRVVYFLARTRLAQRIIMVGTVIWIGILV 524
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Cavefish
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161])

HSP 1 Score: 60.077 bits (144), Expect = 1.640e-8
Identity = 46/156 (29.49%), Postives = 82/156 (52.56%), Query Frame = 1 
Query:  859 MVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKH-----RIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDC 1305
            +V SK+ L  +    V +S+  SLGI  Y G+ + +L   E+ P+LV+ +G++N  +I ++      D  ++H     +I + L     ++  +  SE     LG  +  PA++ F   A + +  DF LQI+ FV++L +D++R E +  DI  C
Sbjct:  596 LVDSKISLGIAGILIVLSSVISSLGIFSYAGVPL-TLIVIEVIPFLVLAVGVDNIFIIVQTFQR---DERLQHEELHQQIGRILGDVAPSMLLSSFSEALAFFLGSLSHMPAVKTFSFFAGLAIIIDFILQISCFVSLLGLDIKRQERNRLDILCC 747
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Cavefish
Match: ptch1 (patched 1 [Source:NCBI gene;Acc:103030480])

HSP 1 Score: 54.6842 bits (130), Expect = 7.433e-7
Identity = 37/163 (22.70%), Postives = 79/163 (48.47%), Query Frame = 1 
Query:  856 EMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVD--LPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDCYHNQLLNSI 1332
            +  KS+  +  +    V  S+   LG+C  IGI   +   +++ P+L + +G+++  ++  +   T  +  +P + R  + L++ G +++   IS I    +      PA++ F L A + +  +F + +  F  +LS+D+ R E    DI  C+ +   N +
Sbjct:  451 DCAKSQGAVGLAGVLLVTLSVAAGLGLCSLIGISF-NAATTQVLPFLALGVGVDDVFLLAHAFSETGQNRRIPFEDRTGECLKRTGASVALTSISNITAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFVSPCANRV 612
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Cavefish
Match: ptch1 (patched 1 [Source:NCBI gene;Acc:103030480])

HSP 1 Score: 54.299 bits (129), Expect = 9.109e-7
Identity = 37/163 (22.70%), Postives = 79/163 (48.47%), Query Frame = 1 
Query:  856 EMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVD--LPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDCYHNQLLNSI 1332
            +  KS+  +  +    V  S+   LG+C  IGI   +   +++ P+L + +G+++  ++  +   T  +  +P + R  + L++ G +++   IS I    +      PA++ F L A + +  +F + +  F  +LS+D+ R E    DI  C+ +   N +
Sbjct:  451 DCAKSQGAVGLAGVLLVTLSVAAGLGLCSLIGISF-NAATTQVLPFLALGVGVDDVFLLAHAFSETGQNRRIPFEDRTGECLKRTGASVALTSISNITAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFVSPCANRV 612
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Cavefish
Match: NPC1L1 (NPC1 like intracellular cholesterol transporter 1 [Source:NCBI gene;Acc:103040688])

HSP 1 Score: 52.373 bits (124), Expect = 3.329e-6
Identity = 44/167 (26.35%), Postives = 82/167 (49.10%), Query Frame = 1 
Query:  835 YFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSL--------GIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDC 1305
            Y S ++I +V SK+ +       V  S+  S+G   ++GI   SL   ++ P+LV+ +G +N  +    ++    D   + R  +  E++   +  ++   + + SL        G  +  PA++ F L A + +  DF LQ+T FV +LS+D RR + +  D+  C
Sbjct:  672 YTSFKRI-LVDSKIVVGLGGILIVGCSVLTSMGFYGWVGI-PSSLIIVQVVPFLVLAVGADNIFIF---VLEYQRD---ERRSGETREEQIGRVLGSVAPSMLLCSLSESVCFFLGALSTMPAVKTFALYAALSVLIDFLLQMTAFVALLSLDARRQDANRYDVACC 830
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Sea Lamprey
Match: scap (SREBF chaperone [Source:ZFIN;Acc:ZDB-GENE-040107-41])

HSP 1 Score: 264.233 bits (674), Expect = 7.974e-73
Identity = 168/464 (36.21%), Postives = 264/464 (56.90%), Query Frame = 1 
Query:   28 NNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDK-------------------KLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYNL-------------FPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSR--KRF-----IKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKY--NNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI 1296
               + KI + +Y++G  CAS+P+ I+A     ++  C PLL        P      F+  + +    D+                   + + YVQQ++++      E  +  P++     LS+ F+++ EI   H++ +   E G  +L+D  + +              P   CL +SP   W    + F +D +++ T++    K F     +K++ FG+P   +G+S  + + +   +++A+T +L  YD  F+  L ++LK  Y   N S+ E  DS   + +  +  ++  +PL+ TY+IL  Y+YFS RKI++VKSK GLA +A  TV +SL +S+G+C   G+  P+L G EIFPYLV++IGLEN LV+TKS+V+TPVD  VK RIAQGL  EGW+I KN+ +E+FI+ +G FT  PAIQEF L AL+G+ +DFFLQ+ FF TVL+ID+RRMELSD+
Sbjct:    5 EKLKEKISQGFYSHGLMCASYPVPIIAFTFICVLACCSPLLKLPLPGTGPVE----FVTPVQDYSPPDEQYAASGASDSEERPSWYVGRPVAYVQQVVLKATVFPWERGLI-PVDAFRGPLSKVFELLEEI---HNHQQTTSE-GPRSLDDYCFRVAALLPGLRALQRFLPEHGCLVVSPANFWLNDIEHFRADPDVMSTVHQHQGKAFQFSTSLKDLLFGVPPKYSGVSRYYIRNRQRLVSFAVTIVLHSYDNRFVWGLRSRLKRLYPATNASLRE--DSMVHVHFQEEVGVAELVPLVTTYIILFAYIYFSTRKIDLVKSKWGLALAAVATVISSLLISVGLCTLFGL-TPTLNGGEIFPYLVLVIGLENILVLTKSVVSTPVDQDVKFRIAQGLSNEGWSIVKNMATELFIVLIGYFTMVPAIQEFCLFALVGIVSDFFLQMFFFTTVLAIDIRRMELSDL 456
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Sea Lamprey
Match: npc1 (Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB-GENE-030131-3161])

HSP 1 Score: 59.6918 bits (143), Expect = 4.508e-9
Identity = 43/143 (30.07%), Postives = 73/143 (51.05%), Query Frame = 1 
Query:  862 VKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATP--VDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRME 1284
            V SK+ LA +    V  S+  SLGI  Y GI + +L   E+ P+LV+ +G++N  ++ ++        +     +I + L     ++     SE     LG  +  PA++ F L A + +  DF LQ+T FV+++ +D RR E
Sbjct:  645 VDSKISLAMAGIAIVLCSVSSSLGIFSYAGIPL-TLIVIEVIPFLVLAVGVDNIFILVQAYQRDERRAEEKAHEQIGRILGDIAPSMLLTSTSETLAFFLGALSDMPAVRTFSLFAGMAVLIDFLLQVTCFVSLMGLDARRQE 786
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Nematostella
Match: EDO48953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI14])

HSP 1 Score: 237.269 bits (604), Expect = 4.374e-64
Identity = 182/574 (31.71%), Postives = 271/574 (47.21%), Query Frame = 1 
Query:  313 EIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYN--------------LFPTFSCLFLSPLQLWEMKTDKFSSDENILKTI---NSRKRF---IKEMFFGLPWLKTGI-SSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLY----NTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGH---KRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNLFHSV-----------FLRNIISLPLQ---------PDI------------------HIDLTDDWKLLAMHHWPRLAQIYSINITDRKLFVLPS 1836
            E++  AL   F + N +    DY +  +   D+ L+  S+                 P   CL LSP  LW    ++F  D++++  +   + R      +KE  FG+P   TG+   V      H I YA+T +L   + +F++ L   L  ++  + VHE  D G ++++         L    P+ + Y ++ LY+ FSV KI+MVKSK GLAFSA  TV ASL M+ G+C   G+ VP+L  SEIFPYLV++IG+EN LVITKS+V+TPVDL VKHR+AQGL KEG  + KNL+ EI +L LG  T+  AIQEF L AL+GL TDFFLQ+  F T+LSID+RRME   +R     +L +S  E +                                         SN+   H       + + +         +P+   +RL   YFWA  RI Q+ +M+ A ++ L+++ +  +   +             +  +I    Q         PD                    I  +  W  L+  HWP+L   Y I++  R + +LP+
Sbjct:   39 EVLRVALKPAFLVTNSLM---DYQKNGIGLPDMCLHVASHGAIRQRSGLRLRDSQFLPAEGCLLLSPANLWNKSLERFEEDDHLVDDLYQEHGRPAINIALKEFIFGVPLKHTGLHPQVKWSGHEHNIRYAVTLMLNPDEPSFVEGLRNHLWKQFPGM-VHE--DHGSQVVHIYYKGEGGSLVELGPISVAYFVVFLYLAFSVAKIDMVKSKWGLAFSAVITVIASLIMAAGLCTMFGL-VPTLNSSEIFPYLVIMIGVENILVITKSVVSTPVDLDVKHRVAQGLSKEGKYMLKNLLWEILVLGLGYLTYVHAIQEFALFALVGLLTDFFLQVFMFATILSIDIRRMEGILLRQ--RGRLHSSTTEAT-----------------------------------------SNVQPVHLLPPLPPASVKSPGTPHPSTALPLRKSKRLEIAYFWASTRIVQKALMVFAVMYFLYMVFFVPSTLSTADEQGPNPDDESLIEKMIREAFQDSATKDHAIPDPDRPLSGTQGHKSMQQNLDQIPQSASWTSLSNKHWPQLLSYYDISLVGRYISLLPA 562
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Nematostella
Match: EDO42868 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0G1])

HSP 1 Score: 64.6994 bits (156), Expect = 2.059e-10
Identity = 61/240 (25.42%), Postives = 115/240 (47.92%), Query Frame = 1 
Query:  613 KKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNN---ISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIE--MVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSI--VATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELS--DIRDC 1305
            +KKN K         + ++K F+D + + +K   N+   IS        +EL   ++T +++ L       + +      +   E  M+ SK  L F     V  S+  S+G   Y+G+   +L   E+ P+LV+ +G++N  ++ ++   +    + PV  +I+  L +   ++  + +SE      G  +  PA++ F L A   ++ DF LQIT+FV ++S+D +R E +  DI  C
Sbjct:  562 EKKNAKA--------ESWEKAFIDHMKSYVKHPENSNLTISFSSERSIQDELDRESETDIATILVSYTIMFVYITIALGQINSCERIMIDSKFTLGFCGIIIVLCSVICSIGFWSYVGVPA-TLIIIEVIPFLVLAVGVDNFFIMVQAYQRINRYSNEPVSKKISCALGEVAPSMLLSSLSESVAFGFGAMSDMPAVKVFSLYASFAVAVDFILQITWFVALMSLDAKRQETNRWDIMCC 792
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Nematostella
Match: EDO46942 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNK5])

HSP 1 Score: 61.6178 bits (148), Expect = 1.947e-9
Identity = 44/145 (30.34%), Postives = 75/145 (51.72%), Query Frame = 1 
Query:  862 VKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVA-TPVDLPVKH---RIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRME 1284
            +K+ LG+A   C  V  S+ +S G+    G+     P   + P+L++ IG+++  VI ++    TP +   K    RIA  L+  G +I+   +++     +G  T  P +Q F + A +G+  DF LQIT F   L++D RR +
Sbjct:  882 LKAWLGVAGVIC--VGLSIGVSFGMSSAFGVFYG--PVHSVLPFLLLGIGVDDMFVIVQAWNNLTPEEHKTKEVHERIALTLQHAGCSITITSLTDFLAFLIGASTVLPGLQSFCIYAGLGILIDFILQITLFSAFLTLDGRRED 1022
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Nematostella
Match: EDO39186 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAU6])

HSP 1 Score: 54.6842 bits (130), Expect = 1.826e-7
Identity = 34/142 (23.94%), Postives = 74/142 (52.11%), Query Frame = 1 
Query:  880 LAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDC 1305
            LA +  F VA  +    G+ + +GI   SL G  + P+L++ IG+++  ++   +      L V   I   +   G  ++   ++++   ++   T  P+I+ F + A + ++  + + IT+FV + + D+RR++ ++ RDC
Sbjct:  107 LANAGVFAVALGVLAGFGLSLAVGIPFISLVG--VLPFLILGIGIDDMFILVDELDRQDNKLSVIDTIKMVMRHSGMTVTMTTVTDLVAFAVSTSTAFPSIRYFCIYAALSVTLSYLMIITYFVAIATFDVRRIK-ANRRDC 245
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Nematostella
Match: EDO36972 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH24])

HSP 1 Score: 55.0694 bits (131), Expect = 1.872e-7
Identity = 34/142 (23.94%), Postives = 74/142 (52.11%), Query Frame = 1 
Query:  880 LAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDC 1305
            LA +  F VA  +    G+ + +GI   SL G  + P+L++ IG+++  ++   +      L V   I   +   G  ++   ++++   ++   T  P+I+ F + A + ++  + + IT+FV + + D+RR++ ++ RDC
Sbjct:  288 LANAGVFAVALGVLAGFGLSLAVGIPFISLVG--VLPFLILGIGIDDMFILVDELDRQDNKLSVIDTIKMVMRHSGMTVTMTTVTDLVAFAVSTSTAFPSIRYFCIYAALSVTLSYLMIITYFVAIATFDVRRIK-ANRRDC 426
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Medaka
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:101156605])

HSP 1 Score: 275.789 bits (704), Expect = 2.996e-76
Identity = 171/454 (37.67%), Postives = 261/454 (57.49%), Query Frame = 1 
Query:   25 KNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPF-------------HQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEA---------CLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI 1296
            +   R KI   +Y++G  CAS+P+ I+    + I+  CYPLL        P              H+      +  + Y      + Y+QQ++V+      +S +  P+++    L + F+++ EI+  H Y ++         CL+  D+     +   + P   CL +SP   W+ + + F SD ++ KTI   +         ++++ FG+P   +G+S  + KK+   + Y IT +L  YD  FL+SL A+LK  + + +     D    + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MV+SK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+
Sbjct:    4 REQLRAKISAAFYHHGLLCASYPVPIILFTSASILTCCYPLLKLPLPGTGPVEFTTGVRDYSVPSHEPHGDQGERPDWYRGPP--VAYIQQVLVKAAVSPWDSSLV-PVDVFRSPLGQVFRLLEEIR-NHVYSDSSGVRSLESLCLQVTDLFPGLRRMQTVLPEHGCLLVSPGNYWQNQRELFDSDPDLFKTIQKHEPKGLHTSATLRDLLFGVPGKYSGVSH-YNKKR--VVTYTITVVLVSYDARFLNSLRARLKQLHPSANCSLREDHMVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVRSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWSIMKNMATELCIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL 449
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Medaka
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:101156605])

HSP 1 Score: 275.018 bits (702), Expect = 5.524e-76
Identity = 171/454 (37.67%), Postives = 261/454 (57.49%), Query Frame = 1 
Query:   25 KNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPF-------------HQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEA---------CLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI 1296
            +   R KI   +Y++G  CAS+P+ I+    + I+  CYPLL        P              H+      +  + Y      + Y+QQ++V+      +S +  P+++    L + F+++ EI+  H Y ++         CL+  D+     +   + P   CL +SP   W+ + + F SD ++ KTI   +         ++++ FG+P   +G+S  + KK+   + Y IT +L  YD  FL+SL A+LK  + + +     D    + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MV+SK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+
Sbjct:    4 REQLRAKISAAFYHHGLLCASYPVPIILFTSASILTCCYPLLKLPLPGTGPVEFTTGVRDYSVPSHEPHGDQGERPDWYRGPP--VAYIQQVLVKAAVSPWDSSLV-PVDVFRSPLGQVFRLLEEIR-NHVYSDSSGVRSLESLCLQVTDLFPGLRRMQTVLPEHGCLLVSPGNYWQNQRELFDSDPDLFKTIQKHEPKGLHTSATLRDLLFGVPGKYSGVSH-YNKKR--VVTYTITVVLVSYDARFLNSLRARLKQLHPSANCSLREDHMVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVRSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWSIMKNMATELCIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL 449
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Medaka
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:101156605])

HSP 1 Score: 275.018 bits (702), Expect = 6.347e-76
Identity = 171/454 (37.67%), Postives = 261/454 (57.49%), Query Frame = 1 
Query:   25 KNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPF-------------HQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEA---------CLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI 1296
            +   R KI   +Y++G  CAS+P+ I+    + I+  CYPLL        P              H+      +  + Y      + Y+QQ++V+      +S +  P+++    L + F+++ EI+  H Y ++         CL+  D+     +   + P   CL +SP   W+ + + F SD ++ KTI   +         ++++ FG+P   +G+S  + KK+   + Y IT +L  YD  FL+SL A+LK  + + +     D    + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MV+SK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+
Sbjct:    4 REQLRAKISAAFYHHGLLCASYPVPIILFTSASILTCCYPLLKLPLPGTGPVEFTTGVRDYSVPSHEPHGDQGERPDWYRGPP--VAYIQQVLVKAAVSPWDSSLV-PVDVFRSPLGQVFRLLEEIR-NHVYSDSSGVRSLESLCLQVTDLFPGLRRMQTVLPEHGCLLVSPGNYWQNQRELFDSDPDLFKTIQKHEPKGLHTSATLRDLLFGVPGKYSGVSH-YNKKR--VVTYTITVVLVSYDARFLNSLRARLKQLHPSANCSLREDHMVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVRSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWSIMKNMATELCIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL 449
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Medaka
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:101156605])

HSP 1 Score: 275.404 bits (703), Expect = 7.479e-76
Identity = 171/454 (37.67%), Postives = 261/454 (57.49%), Query Frame = 1 
Query:   25 KNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPF-------------HQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEA---------CLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI 1296
            +   R KI   +Y++G  CAS+P+ I+    + I+  CYPLL        P              H+      +  + Y      + Y+QQ++V+      +S +  P+++    L + F+++ EI+  H Y ++         CL+  D+     +   + P   CL +SP   W+ + + F SD ++ KTI   +         ++++ FG+P   +G+S  + KK+   + Y IT +L  YD  FL+SL A+LK  + + +     D    + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MV+SK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+
Sbjct:   53 REQLRAKISAAFYHHGLLCASYPVPIILFTSASILTCCYPLLKLPLPGTGPVEFTTGVRDYSVPSHEPHGDQGERPDWYRGPP--VAYIQQVLVKAAVSPWDSSLV-PVDVFRSPLGQVFRLLEEIR-NHVYSDSSGVRSLESLCLQVTDLFPGLRRMQTVLPEHGCLLVSPGNYWQNQRELFDSDPDLFKTIQKHEPKGLHTSATLRDLLFGVPGKYSGVSH-YNKKR--VVTYTITVVLVSYDARFLNSLRARLKQLHPSANCSLREDHMVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVRSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWSIMKNMATELCIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL 498
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Medaka
Match: scap (SREBF chaperone [Source:NCBI gene;Acc:101156605])

HSP 1 Score: 275.018 bits (702), Expect = 7.657e-76
Identity = 171/454 (37.67%), Postives = 261/454 (57.49%), Query Frame = 1 
Query:   25 KNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPF-------------HQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEA---------CLETGDINLN-DKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRK-------RFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDI 1296
            +   R KI   +Y++G  CAS+P+ I+    + I+  CYPLL        P              H+      +  + Y      + Y+QQ++V+      +S +  P+++    L + F+++ EI+  H Y ++         CL+  D+     +   + P   CL +SP   W+ + + F SD ++ KTI   +         ++++ FG+P   +G+S  + KK+   + Y IT +L  YD  FL+SL A+LK  + + +     D    + +  +  ++  +PL+ TY+IL  Y+YFS RKI+MV+SK GLA +A  TV +SL MS+G+C   G+  P+L G EIFPYLVV+IGLEN LV+TKS+V+TPVDL VK RIAQGL  E W+I KN+ +E+ I+ +G FT  PAIQEF L A++GL +DFFLQ+ FF TVLSID+RRMEL+D+
Sbjct:    4 REQLRAKISAAFYHHGLLCASYPVPIILFTSASILTCCYPLLKLPLPGTGPVEFTTGVRDYSVPSHEPHGDQGERPDWYRGPP--VAYIQQVLVKAAVSPWDSSLV-PVDVFRSPLGQVFRLLEEIR-NHVYSDSSGVRSLESLCLQVTDLFPGLRRMQTVLPEHGCLLVSPGNYWQNQRELFDSDPDLFKTIQKHEPKGLHTSATLRDLLFGVPGKYSGVSH-YNKKR--VVTYTITVVLVSYDARFLNSLRARLKQLHPSANCSLREDHMVHVHFKEEIGIAELIPLVTTYIILFAYIYFSTRKIDMVRSKWGLALAAVVTVLSSLLMSVGLCTLFGL-TPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLEVKLRIAQGLSNESWSIMKNMATELCIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMFFFTTVLSIDIRRMELADL 449
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Planmine SMEST
Match: SMESG000032620.1 (SMESG000032620.1)

HSP 1 Score: 1657.11 bits (4290), Expect = 0.000e+0
Identity = 826/826 (100.00%), Postives = 826/826 (100.00%), Query Frame = 1 
Query:    1 MNVKLPQNKNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRKRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNLFHSVFLRNIISLPLQPDIHIDLTDDWKLLAMHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITPKALVDKDPFSKDHQRNNWLSSQILSGTNDLFMQIPSSLRGWADLSLTFKMVLASIVGMGIVLMSTALIMTLFQALQSISGDNREPVLRILPLKIDTEFAVPPGANCISCGPIIMANGLEIYDPINIAFKIKSWNIDTGQLLEEKHRKGVWDIVYIENNWIMLGFDSGIVELWRRSADNINVCEIDSINLTRGGILKMFFWINE 2478
            MNVKLPQNKNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRKRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHLPLLITYLILMLYVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNLFHSVFLRNIISLPLQPDIHIDLTDDWKLLAMHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITPKALVDKDPFSKDHQRNNWLSSQILSGTNDLFMQIPSSLRGWADLSLTFKMVLASIVGMGIVLMSTALIMTLFQALQSISGDNREPVLRILPLKIDTEFAVPPGANCISCGPIIMANGLEIYDPINIAFKIKSWNIDTGQLLEEKHRKGVWDIVYIENNWIMLGFDSGIVELWRRSADNINVCEIDSINLTRGGILKMFFWINE
Sbjct:    1 MNVKLPQNKNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRKRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHLPLLITYLILMLYVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFIILYSTNLFHSVFLRNIISLPLQPDIHIDLTDDWKLLAMHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITPKALVDKDPFSKDHQRNNWLSSQILSGTNDLFMQIPSSLRGWADLSLTFKMVLASIVGMGIVLMSTALIMTLFQALQSISGDNREPVLRILPLKIDTEFAVPPGANCISCGPIIMANGLEIYDPINIAFKIKSWNIDTGQLLEEKHRKGVWDIVYIENNWIMLGFDSGIVELWRRSADNINVCEIDSINLTRGGILKMFFWINE 826
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Planmine SMEST
Match: SMESG000032620.1 (SMESG000032620.1)

HSP 1 Score: 995.342 bits (2572), Expect = 0.000e+0
Identity = 502/504 (99.60%), Postives = 503/504 (99.80%), Query Frame = 1 
Query:    1 MNVKLPQNKNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRKRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHXXXXXXXXXXXXXVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASDIN 1512
            MNVKLPQNKNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRKRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHLPLLITYLILMLYVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKAS+I 
Sbjct:    1 MNVKLPQNKNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLLNTSFHSNTPFHQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDINNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYNLFPTFSCLFLSPLQLWEMKTDKFSSDENILKTINSRKRFIKEMFFGLPWLKTGISSVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSGEELLYNTQTYLSSHLPLLITYLILMLYVYFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVATPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSLDWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKASEIG 504
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Planmine SMEST
Match: SMESG000032620.1 (SMESG000032620.1)

HSP 1 Score: 492.656 bits (1267), Expect = 4.635e-167
Identity = 239/239 (100.00%), Postives = 239/239 (100.00%), Query Frame = 1 
Query: 1762 MHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITPKALVDKDPFSKDHQRNNWLSSQILSGTNDLFMQIPSSLRGWADLSLTFKMVLASIVGMGIVLMSTALIMTLFQALQSISGDNREPVLRILPLKIDTEFAVPPGANCISCGPIIMANGLEIYDPINIAFKIKSWNIDTGQLLEEKHRKGVWDIVYIENNWIMLGFDSGIVELWRRSADNINVCEIDSINLTRGGILKMFFWINE 2478
            MHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITPKALVDKDPFSKDHQRNNWLSSQILSGTNDLFMQIPSSLRGWADLSLTFKMVLASIVGMGIVLMSTALIMTLFQALQSISGDNREPVLRILPLKIDTEFAVPPGANCISCGPIIMANGLEIYDPINIAFKIKSWNIDTGQLLEEKHRKGVWDIVYIENNWIMLGFDSGIVELWRRSADNINVCEIDSINLTRGGILKMFFWINE
Sbjct:    1 MHHWPRLAQIYSINITDRKLFVLPSWNLLNDIKITPKALVDKDPFSKDHQRNNWLSSQILSGTNDLFMQIPSSLRGWADLSLTFKMVLASIVGMGIVLMSTALIMTLFQALQSISGDNREPVLRILPLKIDTEFAVPPGANCISCGPIIMANGLEIYDPINIAFKIKSWNIDTGQLLEEKHRKGVWDIVYIENNWIMLGFDSGIVELWRRSADNINVCEIDSINLTRGGILKMFFWINE 239
[Close]
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Planmine SMEST
Match: SMESG000005000.1 (SMESG000005000.1)

HSP 1 Score: 55.0694 bits (131), Expect = 3.393e-7
Identity = 45/155 (29.03%), Postives = 82/155 (52.90%), Query Frame = 1 
Query:  835 YFSVRKIEMVKSKLGLAFSACFTVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVA-----TPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLLALIGLSTDFFLQITFFVTVLSIDMRRME 1284
            Y +++KI  V SK+ L   A   V  S+  S+G   Y+ + + +L   E+ P+LV+ +G++N  ++ ++        +  +L  + +IA+ + K G ++  + +SE      G+ T  PA++ F L A   +  DF LQIT  + VL +D +R E
Sbjct:  543 YNNIKKIP-VDSKVTLGLCAVLIVLISVTCSVGFWSYLNVPM-TLIILEVVPFLVLAVGVDNLFILVQTYQRYDEYYSSKNLTTEQKIARVVSKVGPSMLLSSLSESLAFFCGVMTEMPAVKIFSLYAATAVLFDFLLQITVLIAVLILDAKRSE 695
The following BLAST results are available for this feature:
BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SCAP4.314e-7834.49SREBF chaperone [Source:HGNC Symbol;Acc:HGNC:30634... [more]
SCAP4.314e-7834.49SREBF chaperone [Source:HGNC Symbol;Acc:HGNC:30634... [more]
SCAP2.312e-5063.01SREBF chaperone [Source:HGNC Symbol;Acc:HGNC:30634... [more]
SCAP2.280e-1431.98SREBF chaperone [Source:HGNC Symbol;Acc:HGNC:30634... [more]
NPC14.645e-928.57NPC intracellular cholesterol transporter 1 [Sourc... [more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
scp-13.710e-5927.92SREBP Cleavage activating Protein (SCAP) homolog ... [more]
daf-61.938e-925.81pep chromosome:WBcel235:X:14888488:14894297:1 gene... [more]
ptr-163.635e-929.00PaTched Related family [Source:UniProtKB/TrEMBL;A... [more]
ptr-164.282e-929.00PaTched Related family [Source:UniProtKB/TrEMBL;A... [more]
ptr-186.163e-930.34PaTched Related family [Source:UniProtKB/TrEMBL;A... [more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SCAP1.078e-6329.78gene:FBgn0033052 transcript:FBtr0086027[more]
Npc1a7.525e-1131.17gene:FBgn0024320 transcript:FBtr0343610[more]
Npc1a7.525e-1131.17gene:FBgn0024320 transcript:FBtr0343609[more]
Npc1a7.525e-1131.17gene:FBgn0024320 transcript:FBtr0343608[more]
Npc1a7.791e-1131.17gene:FBgn0024320 transcript:FBtr0303907[more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
scap1.268e-7837.78SREBF chaperone [Source:ZFIN;Acc:ZDB-GENE-040107-4... [more]
scap1.268e-7837.78SREBF chaperone [Source:ZFIN;Acc:ZDB-GENE-040107-4... [more]
npc11.276e-1030.99Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB... [more]
npc11.307e-1030.99Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB... [more]
npc11.342e-1030.99Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB... [more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
scap1.493e-8332.06SREBF chaperone [Source:NCBI gene;Acc:100145201][more]
scap1.559e-7934.04SREBF chaperone [Source:NCBI gene;Acc:100145201][more]
scap2.044e-7934.04SREBF chaperone [Source:NCBI gene;Acc:100145201][more]
scap4.416e-7934.04SREBF chaperone [Source:NCBI gene;Acc:100145201][more]
fosl15.528e-1031.25FOS-like antigen 1 [Source:Xenbase;Acc:XB-GENE-625... [more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Scap5.117e-7734.47SREBF chaperone [Source:MGI Symbol;Acc:MGI:2135958... [more]
Ptch21.143e-821.29patched 2 [Source:MGI Symbol;Acc:MGI:1095405][more]
Npc12.453e-826.60NPC intracellular cholesterol transporter 1 [Sourc... [more]
Ptch18.929e-722.50patched 1 [Source:MGI Symbol;Acc:MGI:105373][more]
Ptch19.002e-722.50patched 1 [Source:MGI Symbol;Acc:MGI:105373][more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|A6QM06|SCAP_BOVIN6.170e-7834.44Sterol regulatory element-binding protein cleavage... [more]
sp|Q5MNU5|SCAP_PIG7.404e-7834.51Sterol regulatory element-binding protein cleavage... [more]
sp|Q12770|SCAP_HUMAN2.072e-7734.49Sterol regulatory element-binding protein cleavage... [more]
sp|A2RRU4|SCAP_RAT8.389e-7734.47Sterol regulatory element-binding protein cleavage... [more]
sp|P97260|SCAP_CRIGR1.028e-7634.42Sterol regulatory element-binding protein cleavage... [more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0L8I2Z23.289e-9835.87SSD domain-containing protein OS=Octopus bimaculoi... [more]
A0A0L8I3056.148e-9635.87Uncharacterized protein OS=Octopus bimaculoides OX... [more]
V4AN662.103e-9538.03Uncharacterized protein OS=Lottia gigantea OX=2251... [more]
A0A2C9JN452.282e-9434.85Uncharacterized protein OS=Biomphalaria glabrata O... [more]
A0A4E0RPI74.126e-9335.88Sterol regulatory element-binding protein cleavage... [more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
scap4.090e-8233.92SREBF chaperone [Source:NCBI gene;Acc:111190066][more]
npc11.640e-829.49Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB... [more]
ptch17.433e-722.70patched 1 [Source:NCBI gene;Acc:103030480][more]
ptch19.109e-722.70patched 1 [Source:NCBI gene;Acc:103030480][more]
NPC1L13.329e-626.35NPC1 like intracellular cholesterol transporter 1 ... [more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
scap7.974e-7336.21SREBF chaperone [Source:ZFIN;Acc:ZDB-GENE-040107-4... [more]
npc14.508e-930.07Niemann-Pick disease, type C1 [Source:ZFIN;Acc:ZDB... [more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO489534.374e-6431.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO428682.059e-1025.42Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO469421.947e-930.34Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO391861.826e-723.94Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO369721.872e-723.94Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
scap2.996e-7637.67SREBF chaperone [Source:NCBI gene;Acc:101156605][more]
scap5.524e-7637.67SREBF chaperone [Source:NCBI gene;Acc:101156605][more]
scap6.347e-7637.67SREBF chaperone [Source:NCBI gene;Acc:101156605][more]
scap7.479e-7637.67SREBF chaperone [Source:NCBI gene;Acc:101156605][more]
scap7.657e-7637.67SREBF chaperone [Source:NCBI gene;Acc:101156605][more]
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BLAST of Sterol regulatory element-binding protein cleavage-activating protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4
Match NameE-valueIdentityDescription
SMESG000032620.10.000e+0100.00SMESG000032620.1[more]
SMESG000032620.10.000e+099.60SMESG000032620.1[more]
SMESG000032620.14.635e-167100.00SMESG000032620.1[more]
SMESG000005000.13.393e-729.03SMESG000005000.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30029861 ID=SMED30029861|Name=Sterol regulatory element-binding protein cleavage-activating protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3381bp
ATGAATGTCAAATTGCCTCAAAATAAAAATAACTTTCGCTATAAAATTGA
GAAATTATATTATAATTATGGGAAATTTTGTGCCAGTCACCCTATATTAA
TTCTCGCCGGTGTAATTAGCGTTATCATCATTTCATGTTATCCATTATTG
AATACTTCATTCCATAGTAATACCCCATTTCACCAAAGAAAAATATTTCT
CAATGATTTGGTCAACTTGTATTCAGAGGATAAAAAGCTTATTGGTTATG
TTCAACAAATTATAGTTCAAAATCATGCGGAATTAGTAGAATCGGACATA
AATAATCCGATTGAAATTGTTTATGAAGCGTTATCAGAATGCTTTAAGAT
TGTCAATGAAATAAAATTCCGACACGACTATTTGGAAGCATGTTTAGAAA
CTGGTGATATTAATCTCAATGATAAAAGTTATAATTTATTTCCAACTTTT
TCTTGCTTGTTTTTGTCCCCGTTACAATTGTGGGAAATGAAAACCGATAA
ATTCTCCTCAGATGAAAATATACTAAAAACCATTAACTCACGAAAACGTT
TCATTAAAGAAATGTTTTTTGGTTTGCCATGGTTAAAAACGGGAATATCG
AGCGTTTTTACAAAGAAGAAAAATCACAAAATTAATTACGCAATCACTTT
TTTACTGAAGAAATACGATAAAACATTTCTAGATAGTTTATTTGCCCAAT
TGAAAGCAAAGTATAATAATATTAGCGTCCACGAGCCGACGGATTCTGGT
GAAGAATTGCTATATAATACTCAAACATATTTATCCTCTCATCTGCCCCT
TCTAATCACATATTTAATATTGATGCTTTATGTTTATTTTTCTGTCAGAA
AAATTGAAATGGTGAAAAGTAAATTAGGATTAGCATTTAGCGCCTGTTTT
ACTGTTGCAGCTTCTCTTTATATGTCACTTGGAATCTGTATATATATTGG
AATAATTGTGCCCTCATTGCCAGGCAGCGAGATTTTTCCTTACCTAGTTG
TAATTATTGGTCTAGAAAATACTCTTGTCATCACTAAGTCGATAGTTGCG
ACACCTGTGGATTTGCCAGTGAAACATCGCATTGCTCAAGGGCTAGAGAA
GGAAGGTTGGGCAATTTCAAAGAATTTAATATCCGAAATCTTTATTCTCA
GTTTGGGAATTTTCACTTTCAATCCTGCTATTCAAGAATTTTTTCTCCTG
GCATTAATTGGGTTATCTACTGATTTTTTTCTTCAGATTACATTTTTTGT
TACCGTTCTATCAATCGATATGCGTCGAATGGAGCTGAGTGATATCAGAG
ATTGCTATCATAATCAATTGTTGAATTCCATCAACGAGGAATCCAGTTTA
GACTGGCACCTTGGGAAATACAATAGAGATAGTTTCATTATATATTTGTT
TCGATGGATTAAAGATCAATCAATGTCATTTGGAAATAATTATTTATTCA
AAGAAAAGTTAGAGAAATCCAATATTTCAAAAGGCCATAAACGGAAAGCT
TCAGATATCAACACCGCTGCATTTATCCAATCAGATGGGATGGTGCCTGT
TTACATTCCAAGAAGATTGATTTTTCTTTATTTTTGGGCAAAAAATCGAA
TATTCCAAAGATTAGTAATGATAGTTGCTGCTGTTTGGATATTATTTATC
ATATTATATTCAACAAACCTTTTTCACTCAGTATTTCTAAGAAATATAAT
TTCTCTGCCACTCCAGCCTGATATTCATATAGATCTAACAGATGATTGGA
AATTATTAGCAATGCATCATTGGCCTAGACTCGCTCAAATTTATTCTATT
AATATAACAGATCGTAAGCTCTTCGTTCTACCTTCCTGGAATTTATTAAA
CGACATCAAAATCACACCAAAAGCTTTGGTTGATAAAGATCCGTTTAGTA
AAGACCACCAAAGAAACAATTGGTTAAGCAGTCAGATTTTGTCAGGAACC
AATGATTTATTTATGCAAATTCCGAGTAGTTTACGAGGATGGGCTGATCT
TAGTCTTACATTTAAAATGGTTTTGGCTAGTATTGTTGGAATGGGAATCG
TTCTGATGTCCACTGCATTGATTATGACACTTTTTCAAGCTCTGCAAAGT
ATATCTGGTGACAATCGAGAACCTGTGTTGAGAATATTACCGTTAAAGAT
TGACACTGAATTTGCAGTTCCACCCGGTGCCAATTGTATTTCTTGTGGGC
CGATTATAATGGCAAACGGTTTAGAAATTTATGATCCAATCAATATAGCT
TTCAAAATCAAATCCTGGAATATTGACACTGGTCAATTATTGGAAGAAAA
ACATCGCAAAGGTGTTTGGGATATTGTATATATCGAAAACAATTGGATTA
TGCTAGGATTTGATAGTGGGATTGTTGAATTGTGGCGAAGATCGGCCGAT
AACATAAATGTATGTGAAATAGATTCAATCAATTTAACTAGAGGAGGCAT
TTTAAAGATGTTTTTCTGGATAAACGAACATTGTGTTTTTGCTGCAACCA
TCGATGGTTGGATGATTGTATTGACTATCAGAAACAATAAGATTCAAATC
AATAATTCTACTAAAGTATTTATAGAAACAATTAAAGATTTCCACGTATC
AAGTAGCTATAAATTAGCAGTTTGTTCCAATAAATCTATAAAAATATATC
AGTTACCTAGTCTGACCCTTATAGAGTCTTTAAGTTTGATATCAGAGCCG
ATTCTTGCCTCTCATTTTGTCGATTCTTTTTTGGCAGCTACAAATGGTTC
TTTAGAAATTAGTTTGGTTGACACGACTAATTTTAAAAAAACAACCTGGA
ACTGGACATCTTTGGTTCATTGGATTAAGTGTTGCCCGGCGAATTTACGA
TCGTCTAAAACAACTGTTGTGACATTTGATGTTAACGGAGCCATTTGTCT
TTGGTTATTAAATAGGAAAAAACCCATTCGCCAGATTTTAATTGATGCTC
CATCTGTTGTATATCCTGGGCCAATATCTCTAATAAATAACAGCTTGATA
TTTGCTGACAAAGGATACTTACGTTTATTTAATGTTCACCTCAATAAATA
CGAGAGATCTATTCAAATATTAGGCAGCAAATCTATAAAAATCAGTGAAG
TTTATATTGCCGCTGAAAAATGGATTGTTTGTTTAAATCAACGAAAGGAA
TTTATAGTGTTACCTATATCTACTGTAGAATAATTATTATTTATTTTATA
AATTAACAAAGATTTTTGTTGGGCAAAAACTGATGCGAGCCCTTAATTTG
TTTGGCCAGCACGATAATGCCTATATATAATTTTTGAAGGGTAAATTTAA
ATATTTAGGAAAAAATGTAAAAATTAAAGGAAAAATAAAATAATTTTAAA
AAATAAAAAACTCGAAAAATTAATAATAAAA
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protein sequence of SMED30029861-orf-1

>SMED30029861-orf-1 ID=SMED30029861-orf-1|Name=SMED30029861-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1061bp
MNVKLPQNKNNFRYKIEKLYYNYGKFCASHPILILAGVISVIIISCYPLL
NTSFHSNTPFHQRKIFLNDLVNLYSEDKKLIGYVQQIIVQNHAELVESDI
NNPIEIVYEALSECFKIVNEIKFRHDYLEACLETGDINLNDKSYNLFPTF
SCLFLSPLQLWEMKTDKFSSDENILKTINSRKRFIKEMFFGLPWLKTGIS
SVFTKKKNHKINYAITFLLKKYDKTFLDSLFAQLKAKYNNISVHEPTDSG
EELLYNTQTYLSSHLPLLITYLILMLYVYFSVRKIEMVKSKLGLAFSACF
TVAASLYMSLGICIYIGIIVPSLPGSEIFPYLVVIIGLENTLVITKSIVA
TPVDLPVKHRIAQGLEKEGWAISKNLISEIFILSLGIFTFNPAIQEFFLL
ALIGLSTDFFLQITFFVTVLSIDMRRMELSDIRDCYHNQLLNSINEESSL
DWHLGKYNRDSFIIYLFRWIKDQSMSFGNNYLFKEKLEKSNISKGHKRKA
SDINTAAFIQSDGMVPVYIPRRLIFLYFWAKNRIFQRLVMIVAAVWILFI
ILYSTNLFHSVFLRNIISLPLQPDIHIDLTDDWKLLAMHHWPRLAQIYSI
NITDRKLFVLPSWNLLNDIKITPKALVDKDPFSKDHQRNNWLSSQILSGT
NDLFMQIPSSLRGWADLSLTFKMVLASIVGMGIVLMSTALIMTLFQALQS
ISGDNREPVLRILPLKIDTEFAVPPGANCISCGPIIMANGLEIYDPINIA
FKIKSWNIDTGQLLEEKHRKGVWDIVYIENNWIMLGFDSGIVELWRRSAD
NINVCEIDSINLTRGGILKMFFWINEHCVFAATIDGWMIVLTIRNNKIQI
NNSTKVFIETIKDFHVSSSYKLAVCSNKSIKIYQLPSLTLIESLSLISEP
ILASHFVDSFLAATNGSLEISLVDTTNFKKTTWNWTSLVHWIKCCPANLR
SSKTTVVTFDVNGAICLWLLNRKKPIRQILIDAPSVVYPGPISLINNSLI
FADKGYLRLFNVHLNKYERSIQILGSKSIKISEVYIAAEKWIVCLNQRKE
FIVLPISTVE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0032934sterol binding
GO:0005515protein binding
GO:0015485cholesterol binding
Vocabulary: INTERPRO
TermDefinition
IPR030225SCAP
IPR036322WD40_repeat_dom_sf
IPR000731SSD
IPR015943WD40/YVTN_repeat-like_dom_sf
IPR017986WD40_repeat_dom
Vocabulary: cellular component
TermDefinition
GO:0000139Golgi membrane
GO:0005789endoplasmic reticulum membrane
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: biological process
TermDefinition
GO:0008203cholesterol metabolic process
GO:0032933SREBP signaling pathway
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR015943WD40/YVTN repeat-like-containing domain superfamilyGENE3DG3DSA:2.130.10.10coord: 751..1057
e-value: 2.1E-10
score: 42.0
IPR000731Sterol-sensing domainPFAMPF12349Sterol-sensingcoord: 287..435
e-value: 5.3E-45
score: 153.0
IPR000731Sterol-sensing domainPROSITEPS50156SSDcoord: 263..422
score: 36.0
IPR030225Sterol regulatory element-binding protein cleavage-activating proteinPANTHERPTHR46378FAMILY NOT NAMEDcoord: 12..694
IPR036322WD40-repeat-containing domain superfamilySUPERFAMILYSSF50978WD40 repeat-likecoord: 766..1023
NoneNo IPR availableSUPERFAMILYSSF82866Multidrug efflux transporter AcrB transmembrane domaincoord: 265..423
NoneNo IPR availableTMHMMTMhelixcoord: 821..843
NoneNo IPR availableTMHMMTMhelixcoord: 21..43
NoneNo IPR availableTMHMMTMhelixcoord: 371..393
NoneNo IPR availableTMHMMTMhelixcoord: 673..695
NoneNo IPR availableTMHMMTMhelixcoord: 398..420
NoneNo IPR availableTMHMMTMhelixcoord: 541..563
NoneNo IPR availableTMHMMTMhelixcoord: 261..283
NoneNo IPR availableTMHMMTMhelixcoord: 328..350
NoneNo IPR availableTMHMMTMhelixcoord: 296..318