Tyrosine-protein kinase receptor
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029811 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 10
Homology
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: ROR1 (receptor tyrosine kinase like orphan receptor 1 [Source:HGNC Symbol;Acc:HGNC:10256]) HSP 1 Score: 440.654 bits (1132), Expect = 3.524e-139 Identity = 264/751 (35.15%), Postives = 396/751 (52.73%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXS---RSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ---KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFT-SVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
YL L++ + N+T +G+ L C +SG P PTI W K P+V ++ R +++GS L+I +LD +D G++ C A N + SS + V+ S G+CQ ++ +C +++ VY+ +Q E E +I + I + S +C + + CH F C E KPR LC+++CE + C Y ++L +LK +P CE L + C R A P+ K + CYN TG +Y GTVS T G C W + F ++ ++YCRNP Q++APWCFT ++C + C S + + +P ++I I + I +C +KS S + R+ P + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + EF+QEA +M+EL H N++ L+G ++ P C++F+++ +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNILIGE L KISD+GL ++ YS+DYYR +L LPIRWM PEAI +G+F+ +SD+W++GV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECWNE+P RP+FK+IH R+R W+
Sbjct: 2 YLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNG------------KEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLK------LPNCEDLPQPESPEAANCIRIGIPMADPIN-----KNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNP----GNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPS-VAIPLAIALLFFFICVCRNNQKSS--------SAPVQRQ-------PKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSL-LPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWE 695
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: ROR1 (receptor tyrosine kinase like orphan receptor 1 [Source:HGNC Symbol;Acc:HGNC:10256]) HSP 1 Score: 441.425 bits (1134), Expect = 6.205e-139 Identity = 264/753 (35.06%), Postives = 397/753 (52.72%), Query Frame = 3
Query: 345 EGYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXS---RSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ---KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFT-SVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+ YL L++ + N+T +G+ L C +SG P PTI W K P+V ++ R +++GS L+I +LD +D G++ C A N + SS + V+ S G+CQ ++ +C +++ VY+ +Q E E +I + I + S +C + + CH F C E KPR LC+++CE + C Y ++L +LK +P CE L + C R A P+ K + CYN TG +Y GTVS T G C W + F ++ ++YCRNP Q++APWCFT ++C + C S + + +P ++I I + I +C +KS S + R+ P + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + EF+QEA +M+EL H N++ L+G ++ P C++F+++ +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNILIGE L KISD+GL ++ YS+DYYR +L LPIRWM PEAI +G+F+ +SD+W++GV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECWNE+P RP+FK+IH R+R W+
Sbjct: 55 DSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNG------------KEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLK------LPNCEDLPQPESPEAANCIRIGIPMADPIN-----KNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNP----GNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPS-VAIPLAIALLFFFICVCRNNQKSS--------SAPVQRQ-------PKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSL-LPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWE 750
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: ROR2 (receptor tyrosine kinase like orphan receptor 2 [Source:HGNC Symbol;Acc:HGNC:10257]) HSP 1 Score: 423.705 bits (1088), Expect = 3.616e-132 Identity = 256/746 (34.32%), Postives = 384/746 (51.47%), Query Frame = 3
Query: 336 PQFEGY-LKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMC---SEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITG-NSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
P +GY L + + N+T G+ L C ++G P P + W K P+V +I IR++ +GS L+I+DLD +D G+Y C A N T + V + ++ G+CQ ++ +C +++ +YV ++Q E E RI + I + S +C + + CH F +C S KPR LC+++CE + C Y + + +PKCE L + C R +PA + + + CYNG+G +Y GT S T G C W + F ++ + YCRNP Q + PWCFT R E+C V C SP S L I+I VI + + +C +K+ T R+ + P Q+ E L+ +K + + LS +RF E++GE FG VYK L G P G + V +KTL + L+ EF+ EA + + L+H NV+ L+GV + P +IF + GDLHE L+ + S V + D L D + + AQIA+GMEYLSS VH+DLA RN+L+ + L KISD+GL ++ Y++DYY+ G++L LPIRWM+PEAI +G+F+++SD+W+YGV+LWE++S GLQP+ G+SN +V+E++R+RQ+L CPD+CP VY LM+ECWNE P RP+FK+IHSR+R W
Sbjct: 55 PTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTH---------SPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGT--STHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIG-IPAERLG-----RYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNP----GGQMEGPWCFTQNKNVRMELCDVPSC----SPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTP--------QRRQLMA--SPSQD----MEMPLINQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFG-----PAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPH-----SDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSL-LPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAW 749
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: ROR2 (receptor tyrosine kinase like orphan receptor 2 [Source:HGNC Symbol;Acc:HGNC:10257]) HSP 1 Score: 376.711 bits (966), Expect = 4.440e-117 Identity = 222/620 (35.81%), Postives = 329/620 (53.06%), Query Frame = 3
Query: 711 GYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMC---SEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITG-NSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
G+CQ ++ +C +++ +YV ++Q E E RI + I + S +C + + CH F +C S KPR LC+++CE + C Y + + +PKCE L + C R +PA + + + CYNG+G +Y GT S T G C W + F ++ + YCRNP Q + PWCFT R E+C V C SP S L I+I VI + + +C +K+ T R+ + P Q+ E L+ +K + + LS +RF E++GE FG VYK L G P G + V +KTL + L+ EF+ EA + + L+H NV+ L+GV + P +IF + GDLHE L+ + S V + D L D + + AQIA+GMEYLSS VH+DLA RN+L+ + L KISD+GL ++ Y++DYY+ G++L LPIRWM+PEAI +G+F+++SD+W+YGV+LWE++S GLQP+ G+SN +V+E++R+RQ+L CPD+CP VY LM+ECWNE P RP+FK+IHSR+R W
Sbjct: 32 GFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGT--STHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIG-IPAERLG-----RYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNP----GGQMEGPWCFTQNKNVRMELCDVPSC----SPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTP--------QRRQLMA--SPSQD----MEMPLINQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFG-----PAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPH-----SDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSL-LPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAW 609
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Match: MUSK (muscle associated receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7525]) HSP 1 Score: 270.396 bits (690), Expect = 5.508e-77 Identity = 145/352 (41.19%), Postives = 212/352 (60.23%), Query Frame = 3
Query: 1449 FVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPAD---SMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIH 2495
FV++TI+ + C++ K N S +T + + + L K+ S +YP + I + IGEG FG V++A G P T +V VK L +S +Q +F++EA +M+E + N++ L+GV P CL+F++M GDL+E L S + V S+S + + G LS +Q+ IA Q+A+GM YLS R FVHRDLA RN L+GEN++ KI+D GL ++ YS+DYY+ + +PIRWM PE+I + R+T ESDVWAYGV+LWEI+S GLQP+YG ++ EV+ VR ILSCP+NCP ++Y+LM CW+++P RP F +IH
Sbjct: 421 FVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFT----MVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANEND-AIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIH 767
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: cam-1 (Tyrosine-protein kinase receptor cam-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGK5]) HSP 1 Score: 242.276 bits (617), Expect = 1.325e-67 Identity = 125/289 (43.25%), Postives = 171/289 (59.17%), Query Frame = 3
Query: 1647 SQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
SQ+ +E+IGEG FG V+ G + V VK ++ + + +QE + ++ H NV+ L+GV +F++M GDLHELL + PAD G +T + + ++IA QIA GMEYL+S SFVHRDLA RN L+G+ KI+D GL++ Y SDYY+ + M P+RWMS EAI GRF+ SDVW++GV LWEIWS G QP+ G SN +V+ELV +R +L CP NCPT +Y LM+ECW+E RP F I SR++ W
Sbjct: 429 SQLSVREKIGEGQFGVVHS----GIYTSGLFAPEPMAVAVKKCRHDATNAERAQLEQEIRAVATFDHPNVIKLIGVCYMDNSLLAVFEYMVHGDLHELL---------KVRVPPADH--DMGGITEANAEFLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKMLHRSWM-PVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLLECPHNCPTNIYSLMVECWHENIERRPTFSEIRSRLQSW 701 HSP 2 Score: 88.1965 bits (217), Expect = 1.607e-17 Identity = 68/248 (27.42%), Postives = 108/248 (43.55%), Query Frame = 3
Query: 711 GYCQTFQSSSCGKYLSGHMVYVTHGRVQA----EKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPR--RLCQEDCEDVTKKRCNYTYKLMLQ-KLKKDYLVSV-PKCEKLHNNQGCFRF--NELPAVPVK--TKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK-------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNK 1397
G C ++ +C +YLS V +T+ + ++ R A L + +SQ+ C + + CH + +C D + +C+ DC+ + C L Q +L D ++ P C +L + C L + PV + L + CY +G +Y GTV+QT G C W NV F +++ NYCRNP ++ PWC++ G E C V QC D P +D K
Sbjct: 44 GDCVQYRGEACRQYLSNKFVMMTNESREEMYDIDRNLRAAMLFINGAPTISQK----CRQLSQAVACHHMYKVCESDSNNQIVSICKHDCDVIQNDECPSELALAAQHELVGDTPKALFPLCSRLSSTSNCIPVMSTALQSSPVAEVNRGHLTHW-CYVNSGTQYEGTVAQTSSGKQCAPWIDSTSRDFNVHRFPELMNSKNYCRNP----GGKKSRPWCYSKPMGQEEYCDVPQCPSDMYPHLNDKK 282
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: cam-1 (Tyrosine-protein kinase receptor cam-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGK5]) HSP 1 Score: 243.047 bits (619), Expect = 4.973e-67 Identity = 125/289 (43.25%), Postives = 171/289 (59.17%), Query Frame = 3
Query: 1647 SQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
SQ+ +E+IGEG FG V+ G + V VK ++ + + +QE + ++ H NV+ L+GV +F++M GDLHELL + PAD G +T + + ++IA QIA GMEYL+S SFVHRDLA RN L+G+ KI+D GL++ Y SDYY+ + M P+RWMS EAI GRF+ SDVW++GV LWEIWS G QP+ G SN +V+ELV +R +L CP NCPT +Y LM+ECW+E RP F I SR++ W
Sbjct: 562 SQLSVREKIGEGQFGVVHS----GIYTSGLFAPEPMAVAVKKCRHDATNAERAQLEQEIRAVATFDHPNVIKLIGVCYMDNSLLAVFEYMVHGDLHELL---------KVRVPPADH--DMGGITEANAEFLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKMLHRSWM-PVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLLECPHNCPTNIYSLMVECWHENIERRPTFSEIRSRLQSW 834 HSP 2 Score: 88.1965 bits (217), Expect = 1.679e-17 Identity = 68/248 (27.42%), Postives = 108/248 (43.55%), Query Frame = 3
Query: 711 GYCQTFQSSSCGKYLSGHMVYVTHGRVQA----EKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPR--RLCQEDCEDVTKKRCNYTYKLMLQ-KLKKDYLVSV-PKCEKLHNNQGCFRF--NELPAVPVK--TKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK-------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNK 1397
G C ++ +C +YLS V +T+ + ++ R A L + +SQ+ C + + CH + +C D + +C+ DC+ + C L Q +L D ++ P C +L + C L + PV + L + CY +G +Y GTV+QT G C W NV F +++ NYCRNP ++ PWC++ G E C V QC D P +D K
Sbjct: 177 GDCVQYRGEACRQYLSNKFVMMTNESREEMYDIDRNLRAAMLFINGAPTISQK----CRQLSQAVACHHMYKVCESDSNNQIVSICKHDCDVIQNDECPSELALAAQHELVGDTPKALFPLCSRLSSTSNCIPVMSTALQSSPVAEVNRGHLTHW-CYVNSGTQYEGTVAQTSSGKQCAPWIDSTSRDFNVHRFPELMNSKNYCRNP----GGKKSRPWCYSKPMGQEEYCDVPQCPSDMYPHLNDKK 415
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: cam-1 (Tyrosine-protein kinase receptor cam-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EGK5]) HSP 1 Score: 242.662 bits (618), Expect = 7.906e-67 Identity = 125/289 (43.25%), Postives = 171/289 (59.17%), Query Frame = 3
Query: 1647 SQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
SQ+ +E+IGEG FG V+ G + V VK ++ + + +QE + ++ H NV+ L+GV +F++M GDLHELL + PAD G +T + + ++IA QIA GMEYL+S SFVHRDLA RN L+G+ KI+D GL++ Y SDYY+ + M P+RWMS EAI GRF+ SDVW++GV LWEIWS G QP+ G SN +V+ELV +R +L CP NCPT +Y LM+ECW+E RP F I SR++ W
Sbjct: 588 SQLSVREKIGEGQFGVVHS----GIYTSGLFAPEPMAVAVKKCRHDATNAERAQLEQEIRAVATFDHPNVIKLIGVCYMDNSLLAVFEYMVHGDLHELL---------KVRVPPADH--DMGGITEANAEFLYIATQIALGMEYLASMSFVHRDLATRNCLVGDTRTIKIADFGLMRTSYGSDYYKMLHRSWM-PVRWMSKEAIEQGRFSEASDVWSFGVTLWEIWSFGRQPYEGASNQQVIELVANRHLLECPHNCPTNIYSLMVECWHENIERRPTFSEIRSRLQSW 860 HSP 2 Score: 88.1965 bits (217), Expect = 1.787e-17 Identity = 68/248 (27.42%), Postives = 108/248 (43.55%), Query Frame = 3
Query: 711 GYCQTFQSSSCGKYLSGHMVYVTHGRVQA----EKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPR--RLCQEDCEDVTKKRCNYTYKLMLQ-KLKKDYLVSV-PKCEKLHNNQGCFRF--NELPAVPVK--TKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK-------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNK 1397
G C ++ +C +YLS V +T+ + ++ R A L + +SQ+ C + + CH + +C D + +C+ DC+ + C L Q +L D ++ P C +L + C L + PV + L + CY +G +Y GTV+QT G C W NV F +++ NYCRNP ++ PWC++ G E C V QC D P +D K
Sbjct: 203 GDCVQYRGEACRQYLSNKFVMMTNESREEMYDIDRNLRAAMLFINGAPTISQK----CRQLSQAVACHHMYKVCESDSNNQIVSICKHDCDVIQNDECPSELALAAQHELVGDTPKALFPLCSRLSSTSNCIPVMSTALQSSPVAEVNRGHLTHW-CYVNSGTQYEGTVAQTSSGKQCAPWIDSTSRDFNVHRFPELMNSKNYCRNP----GGKKSRPWCYSKPMGQEEYCDVPQCPSDMYPHLNDKK 441
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: src-2 (Tyrosine protein-kinase src-2 [Source:UniProtKB/Swiss-Prot;Acc:O45539]) HSP 1 Score: 172.94 bits (437), Expect = 9.724e-46 Identity = 104/293 (35.49%), Postives = 154/293 (52.56%), Query Frame = 3
Query: 1653 IRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRT-TGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDV 2528
+R QIG G FG V++ N N P V VK L AG++ +F EAQ+M +L+H +LSL V R P ++ + M++ L L ++ + + I+AQ+A+GM YL +F+HRDLAARNILI +L KI+D GL + + Y TG+ PI+W +PEA + RFT +SDVW++G+LL EI + G P+ G +NAEV++ V + + CP CP +YD+M +CW P RP F+ + W+ ED+
Sbjct: 240 VRLIRQIGAGQFGEVWEGRW---NVNVP-------VAVKKLKAGTADPT--DFLAEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQENLLTFLQRRGRQCQMPQL---------------------VEISAQVAAGMAYLEEMNFIHRDLAARNILINNSLSVKIADFGLARILMKENEYEARTGAR--FPIKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVLQQVDAGYRMPCPAGCPVTLYDIMQQCWRSDPDKRPTFETLQ-----WKLEDL 492
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Match: src-1 (Tyrosine protein-kinase src-1 [Source:UniProtKB/Swiss-Prot;Acc:G5EE56]) HSP 1 Score: 169.859 bits (429), Expect = 7.190e-45 Identity = 99/291 (34.02%), Postives = 155/291 (53.26%), Query Frame = 3
Query: 1641 PLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENL----MCKISDIGLIKDCYSSDYYRT-TGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVY-DLMLECWNEMPRYRPQFKNIH 2495
P +Q+ + ++G+G FG V+ + G V +KT+ G+ F QEAQ+M + H N++ L V R+ P+ +I ++M G L + L ++ + TL + +AAQIA+GM YL R VHRDLAARN+L+G+ + + K++D GL + D Y TG+ PI+W +PEA G FTV+SDVW+YG+LL+EI + G P+ G N EV+E V + P CP ++Y +++L+CW++ P RP F ++
Sbjct: 202 PRNQLHLKRKLGDGNFGEVWYGKWRGIVE----------VAIKTMKPGTMSP--EAFLQEAQIMKQCDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLRTDGS--------------------TLGIQALVDMAAQIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKF--PIKWTAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYEEVLLKCWDKTPDRRPTFDTLY 458
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: Ror (gene:FBgn0010407 transcript:FBtr0079978) HSP 1 Score: 299.286 bits (765), Expect = 9.953e-89 Identity = 144/309 (46.60%), Postives = 209/309 (67.64%), Query Frame = 3
Query: 1593 SSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQ 2519
S L++ N + + + L + F E++GEG FG VYK +L+ N + IT V +K L +SVK Q +FK+E +++S+LKH N++ ++GV + + P+C++F++M GDLHE LISN+ E +S+S + + + IA QI+ GM+YLS+ +VHRDLAARN L+ E L+ KISD GL +D YSSDYYR +L LP+RWM E+I +G+FT ESDVW++GV+LWEI+S G+QP+YG SN EV+ L+RSRQ+LS P+NCPT VY LM+ECW+E RP F +I +R++ W +
Sbjct: 391 SKLIERNTL-LRINHFTLQDVEFLEELGEGAFGKVYKGQLLQPNKTT-IT-----VAIKALKENASVKTQQDFKREIELISDLKHQNIVCILGVVLNKEPYCMLFEYMANGDLHEFLISNSPTEGKSLSQL----------------EFLQIALQISEGMQYLSAHHYVHRDLAARNCLVNEGLVVKISDFGLSRDIYSSDYYRVQSKSL-LPVRWMPSESILYGKFTTESDVWSFGVVLWEIYSYGMQPYYGFSNQEVINLIRSRQLLSAPENCPTAVYSLMIECWHEQSVKRPTFTDISNRLKTWHE 675 HSP 2 Score: 54.299 bits (129), Expect = 5.414e-7 Identity = 33/116 (28.45%), Postives = 52/116 (44.83%), Query Frame = 3
Query: 1032 LVSVPKCEKLHNNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTW----KNVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR--EVCSVRQC 1361
+V V C+KL ++ C V K +CY G Y G + + G PC+ W K + F +++ NYCRN P +++PWCF + R E+C + +C
Sbjct: 207 MVGVEDCQKLPQHKDCLSLGITIEVD-------KTENCYWEDGSTYRGVANVSASGKPCLRWSWLMKEISDFPELIGQ-NYCRN----PGSVENSPWCFVDSSRERIIELCDIPKC 310
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: Nrk (gene:FBgn0020391 transcript:FBtr0087728) HSP 1 Score: 271.552 bits (693), Expect = 2.866e-78 Identity = 199/667 (29.84%), Postives = 302/667 (45.28%), Query Frame = 3
Query: 711 GYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIAS-----LVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVS------VPKCEKL-HNNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN-VPG--------FEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDN----KSFRNFLPVYISIGCVIGFVIMT---ISICWICKKSK------------------FGTNGSCHSNGLTRKSYLG-------------------IYKPCQNDCKKSESSLVQLNK--IKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIR 2507
GYC + C +YL+G + Y K ++ + L+++++ L ++A ++ L CH M LC EDC+ + C + L+ +K +++ + +P C L H N R N + K YDC NG GR Y+GT++ + G PC W P F ++ NYCRN E + PWC+T R + C + C P+ D K + F P I + IGFV + + I + K SK G C N T + LG I+ C + S + K ++ +YP I + +G+G FG V++A G + +V VK L +S ++Q +F++EA +++E H N++ L+GV P CL+F++M GDL E L R+ S + L+ + +AA IA+GM YLS R FVHRDLA RN LI E++ KI+D GL Y DYY+ + +PIRWM E+I + +F++ESDVWAYG+ LWE++S LQP++G ++ EV++ ++ +L CPDN P VY LM CWN P RP F I+ I+
Sbjct: 68 GYCAPYSGKVCKEYLTGQVWYSLEDPTGGWKNEQVTTALWDELISDLTG-LCREAAEKMLCAYAFPNCH----MEGGRAVKAPLCFEDCQATHLQFCYNDWVLIEEKKERNMFIKSRGHFRLPNCSSLPHYNASMRRPNCSYIGLTELKESEVSYDCRNGNGRFYMGTMNVSKSGIPCQRWDTQYPHKHFQPPLVFHQLLEGENYCRNAGGE----EPHPWCYTVDESVRWQHCDIPMCPDYVDPNAVDLNTPIKMEKFFTPSMIFLLAGIGFVAIVTLHLMILLVYKLSKHKDYSQPAGAATAECSVSMRGGGDCGGNLNTSRETLGGNGNTNTLAKWGTIRSTATIHSNCVALTTVTNVSDAKGTKPNARLEKLEYPRGDIVYVRSLGQGAFGRVFQARAPGLVPDQ----EDLLVAVKMLKDDASDQMQMDFEREACLLAEFDHPNIVRLLGVCALGRPMCLLFEYMAPGDLSEFL--------RACSPYATHQAPTQDRLQLNELHLLQMAANIAAGMLYLSERKFVHRDLATRNCLINEHMAVKIADFGLSHKIYLQDYYKGDENDF-IPIRWMPLESILYNKFSLESDVWAYGICLWEVFSFALQPYFGLTHEEVIKYIKEGNVLGCPDNTPLSVYALMRRCWNRKPSERPGFAEINHCIQ 712
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: Alk (gene:FBgn0040505 transcript:FBtr0087118) HSP 1 Score: 199.904 bits (507), Expect = 7.478e-52 Identity = 108/306 (35.29%), Postives = 164/306 (53.59%), Query Frame = 3
Query: 1653 IRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILI---GENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDVEIN---PNCIG 2552
++ +G+G FG VY A + ++ G V VKTL + + +F +EA +M++ H N++ L+GV + P+ ++ + + GDL + L N R+ P+ L+ D +F A +A G Y+ S+ F+HRD+AARN L+ G + KI+D G+ +D Y SDYYR G MLPI+WM PEA G FT ++DVW++G+LLWE++S G P+ G N +VMELV L P CP +Y +M +CWN P RP F + + Q+ +N PN +G
Sbjct: 1193 LQLVNALGKGAFGEVYMALYRHRDGDAVEMG----VAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLREN-----RNTPERPS---------LLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKA-MLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILG 1479
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: Alk (gene:FBgn0040505 transcript:FBtr0331926) HSP 1 Score: 199.904 bits (507), Expect = 7.478e-52 Identity = 108/306 (35.29%), Postives = 164/306 (53.59%), Query Frame = 3
Query: 1653 IRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILI---GENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDVEIN---PNCIG 2552
++ +G+G FG VY A + ++ G V VKTL + + +F +EA +M++ H N++ L+GV + P+ ++ + + GDL + L N R+ P+ L+ D +F A +A G Y+ S+ F+HRD+AARN L+ G + KI+D G+ +D Y SDYYR G MLPI+WM PEA G FT ++DVW++G+LLWE++S G P+ G N +VMELV L P CP +Y +M +CWN P RP F + + Q+ +N PN +G
Sbjct: 1193 LQLVNALGKGAFGEVYMALYRHRDGDAVEMG----VAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLREN-----RNTPERPS---------LLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKA-MLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTACTQDASIMNAPLPNILG 1479
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Match: Eph (gene:FBgn0025936 transcript:FBtr0301285) HSP 1 Score: 189.504 bits (480), Expect = 6.146e-49 Identity = 110/285 (38.60%), Postives = 152/285 (53.33%), Query Frame = 3
Query: 1653 IRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCY-SSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRI 2504
I + IG G FG V + L P V +KTL GSS K + +F EA +M + H NV+ L GV R P +I ++ME G L L N D I + IASGM YLS ++VHRDLAARN+L+ L+CKI+D GL ++ +SD Y T G + P+RW +PEAIAF +FT SDVW+YGV+LWE+ S G +P++ SN +V++ + L P +CP +Y LML+CW + +RP F +I S +
Sbjct: 708 ITIEAIIGGGEFGDVCRGRL----KIPPNFVQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRVN--------------------DGKFQTLQLIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKI--PVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL 966
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: ror1 (receptor tyrosine kinase-like orphan receptor 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6104]) HSP 1 Score: 454.521 bits (1168), Expect = 5.693e-144 Identity = 264/748 (35.29%), Postives = 405/748 (54.14%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ---KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHN-----NQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+L+L+ + N+T +G+ L C +SG P P++ W K P+V ++ R + +GS L+I++LD +D G++ C A N++G +TT + + P E+ +G+CQ ++ +C +++ ++V ++Q E E +I + I + S C + + CH F C KPR LC+++CE + C Y L+L++LK +PKCE L C R +P+ + K + CYN +G +Y GTVS T G C W + + ++ ++YCRNP + DAPWCFT R E+C + C S S++ L ++I I + I +C +K+ +R KP + + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL SS + G+F+QEA +++EL H NV+ L+GV ++ P C++F+F+ +GDLHE LI +RS + S D G V +L + D + +A Q+A+GMEYL+S F+H+DLAARNIL+GE L KISD+GL ++ YSSDYYR +TL LPIRWM PEAI +G+++ +SDVWA+GV+LWEI+S GLQP+YG SN EVME+VR RQ+L CP++CP ++Y LM ECW E P RP+FK+IH+R+R W+
Sbjct: 54 FLRLDAPMNNITTSLGQTAELHCHVSGTPSPSVRWLKNDAPVVQEPRRVSYRPTPYGSRLRIKNLDTTDTGYFQCVATNSYGTVSTTGILF-------VKFDPAPTPLPGRPSPEDFDEEGFCQPYRGIACARFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNHLSDRCSQFAIPSLCHFAFPTCDRSSGMDKPRDLCKDECEILENDLCKTEYIIARSNPLILKRLK------LPKCEDLATLDSPEAANCMRI----GIPI-AETINKSHKCYNNSGSDYRGTVSVTKSGRQCQPWNSQYPHSHTFLAMRYPELNGGHSYCRNP----GNKHDAPWCFTLDEAVRMELCDIPPCDLPKHGSSSNSMGILYILVPSVAIPLAIALLFFFICVCRNNQKA-------------SRPPAPRQPKPVRG--QNVEMSMLTAYKPKSKAKELPLSAVRFMEELGESAFGKIYKGHLY-----LPGMEHAQLVAIKTLKDISSAQHWGDFQQEASVLAELHHPNVVCLLGVVTQEQPVCMLFEFLAQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHLAIQVAAGMEYLASHFFIHKDLAARNILVGEQLHIKISDLGLSREIYSSDYYRVQPNTL-LPIRWMPPEAIVYGKYSTDSDVWAFGVVLWEIFSFGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRMYALMTECWQEGPARRPRFKDIHTRLRAWE 750
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: ror1 (receptor tyrosine kinase-like orphan receptor 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6104]) HSP 1 Score: 454.521 bits (1168), Expect = 7.070e-144 Identity = 264/748 (35.29%), Postives = 405/748 (54.14%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSED---QKPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHN-----NQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+L+L+ + N+T +G+ L C +SG P P++ W K P+V ++ R + +GS L+I++LD +D G++ C A N++G +TT + + P E+ +G+CQ ++ +C +++ ++V ++Q E E +I + I + S C + + CH F C KPR LC+++CE + C Y L+L++LK +PKCE L C R +P+ + K + CYN +G +Y GTVS T G C W + + ++ ++YCRNP + DAPWCFT R E+C + C S S++ L ++I I + I +C +K+ +R KP + + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL SS + G+F+QEA +++EL H NV+ L+GV ++ P C++F+F+ +GDLHE LI +RS + S D G V +L + D + +A Q+A+GMEYL+S F+H+DLAARNIL+GE L KISD+GL ++ YSSDYYR +TL LPIRWM PEAI +G+++ +SDVWA+GV+LWEI+S GLQP+YG SN EVME+VR RQ+L CP++CP ++Y LM ECW E P RP+FK+IH+R+R W+
Sbjct: 63 FLRLDAPMNNITTSLGQTAELHCHVSGTPSPSVRWLKNDAPVVQEPRRVSYRPTPYGSRLRIKNLDTTDTGYFQCVATNSYGTVSTTGILF-------VKFDPAPTPLPGRPSPEDFDEEGFCQPYRGIACARFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNHLSDRCSQFAIPSLCHFAFPTCDRSSGMDKPRDLCKDECEILENDLCKTEYIIARSNPLILKRLK------LPKCEDLATLDSPEAANCMRI----GIPI-AETINKSHKCYNNSGSDYRGTVSVTKSGRQCQPWNSQYPHSHTFLAMRYPELNGGHSYCRNP----GNKHDAPWCFTLDEAVRMELCDIPPCDLPKHGSSSNSMGILYILVPSVAIPLAIALLFFFICVCRNNQKA-------------SRPPAPRQPKPVRG--QNVEMSMLTAYKPKSKAKELPLSAVRFMEELGESAFGKIYKGHLY-----LPGMEHAQLVAIKTLKDISSAQHWGDFQQEASVLAELHHPNVVCLLGVVTQEQPVCMLFEFLAQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHLAIQVAAGMEYLASHFFIHKDLAARNILVGEQLHIKISDLGLSREIYSSDYYRVQPNTL-LPIRWMPPEAIVYGKYSTDSDVWAFGVVLWEIFSFGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRMYALMTECWQEGPARRPRFKDIHTRLRAWE 759
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: ror2 (receptor tyrosine kinase-like orphan receptor 2 [Source:ZFIN;Acc:ZDB-GENE-060427-5]) HSP 1 Score: 427.557 bits (1098), Expect = 8.424e-134 Identity = 259/779 (33.25%), Postives = 404/779 (51.86%), Query Frame = 3
Query: 246 LIIIVYMVFLNQPISGFTAKDIKQTDSKQP---PQFEGY-LKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQK-PRR--LCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK-NVPG--------FEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
I + ++ F +++I+ Q P EGY L+ + N+T G+ TL C ++G PRP+I W K P+V ++ IR++ GS L+I+DLD +D G+Y C A N+ + T + V ++ + + + KG+CQ ++ +C +++ +YV ++Q E E RI + I + S Q +C + + C+ F +C E + PRR LC+++CE + CN Y + + +P C L + C R +P + PP ++ CYN +G Y GTVS T G C W P + + +N+CRNP Q ++PWCFT R ++C + C + P + +P S+ + F + IC +C+ + + + LT + P N K ++ L +LN LS +RF E++GE FG VYK L G+ + +V +KT+ L+ EF+ EA + S L+H N++ L+GV ++ P +IF + +GDLHE L+ + S V + D TL D + I Q+A+GMEYLSS VH+DLAARNIL+ + L KI D+GL ++ YS+DYY+ G++ PIRWMSPEAI +G+F+ +SD+W+YGV+LWEI+S GLQP+ G+SN +V+E+VR+RQ+LSCPD+CP +Y +MLECWNE P RP+FK+IH+R+R W+
Sbjct: 22 FIFFATFAYAEADVNLFESEEIEALAEAQSGGLPTPEGYYLEFLEQPNNITIVQGQTATLHCKVAGHPRPSIRWLKNDAPVVQEQGRVSIRKTEAGSKLRIQDLDTTDTGYYQCVATNSIKVISATGVLYV--------RLGNTGQSPAHGAEDSTHEKGFCQPYRGIACARFIGNRSIYVESLQMQGESENRITAAFTMIGT--STQLSDQCSEFAIPSFCYYVFPLCEEGTRGPRRRQLCRDECEALENDLCNAEYTIARSNPLILMQLELPVCSLLPHPGSPDASSCIRI----GLPPQYSPP--DHSCYNESGGNYKGTVSVTKSGFQCQPWSAQYPHSHHLSPIEYPQLRGGHNFCRNP----GGQMESPWCFTLDPNVRVDLCDIPPC---NPPEKMKKELLYILIP---SVATPLVFACLFFLIC-MCRNKQKESVDTPTRRQLTASPSQEMELPLLNQ-HKHQAKLRELN----------LSAVRFMEELGEDRFGKVYKGHLYGTAPGE----QTQVVAIKTVKDKDEGPLREEFRHEAMLRSRLQHPNIVCLLGVITKEQPMSMIFSYSGQGDLHEFLVMRSPH-----SDVGSSDDDKTVKSTLEQADFLHIVTQVAAGMEYLSSHHVVHKDLAARNILVCDKLNVKILDLGLFREVYSADYYKLMGAS-PFPIRWMSPEAILYGKFSTDSDIWSYGVVLWEIFSYGLQPYCGYSNQDVIEMVRNRQVLSCPDDCPAWIYTMMLECWNEFPSRRPRFKDIHARLRTWE 752
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: ror2 (receptor tyrosine kinase-like orphan receptor 2 [Source:ZFIN;Acc:ZDB-GENE-060427-5]) HSP 1 Score: 427.557 bits (1098), Expect = 8.424e-134 Identity = 259/779 (33.25%), Postives = 404/779 (51.86%), Query Frame = 3
Query: 246 LIIIVYMVFLNQPISGFTAKDIKQTDSKQP---PQFEGY-LKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQK-PRR--LCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK-NVPG--------FEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
I + ++ F +++I+ Q P EGY L+ + N+T G+ TL C ++G PRP+I W K P+V ++ IR++ GS L+I+DLD +D G+Y C A N+ + T + V ++ + + + KG+CQ ++ +C +++ +YV ++Q E E RI + I + S Q +C + + C+ F +C E + PRR LC+++CE + CN Y + + +P C L + C R +P + PP ++ CYN +G Y GTVS T G C W P + + +N+CRNP Q ++PWCFT R ++C + C + P + +P S+ + F + IC +C+ + + + LT + P N K ++ L +LN LS +RF E++GE FG VYK L G+ + +V +KT+ L+ EF+ EA + S L+H N++ L+GV ++ P +IF + +GDLHE L+ + S V + D TL D + I Q+A+GMEYLSS VH+DLAARNIL+ + L KI D+GL ++ YS+DYY+ G++ PIRWMSPEAI +G+F+ +SD+W+YGV+LWEI+S GLQP+ G+SN +V+E+VR+RQ+LSCPD+CP +Y +MLECWNE P RP+FK+IH+R+R W+
Sbjct: 22 FIFFATFAYAEADVNLFESEEIEALAEAQSGGLPTPEGYYLEFLEQPNNITIVQGQTATLHCKVAGHPRPSIRWLKNDAPVVQEQGRVSIRKTEAGSKLRIQDLDTTDTGYYQCVATNSIKVISATGVLYV--------RLGNTGQSPAHGAEDSTHEKGFCQPYRGIACARFIGNRSIYVESLQMQGESENRITAAFTMIGT--STQLSDQCSEFAIPSFCYYVFPLCEEGTRGPRRRQLCRDECEALENDLCNAEYTIARSNPLILMQLELPVCSLLPHPGSPDASSCIRI----GLPPQYSPP--DHSCYNESGGNYKGTVSVTKSGFQCQPWSAQYPHSHHLSPIEYPQLRGGHNFCRNP----GGQMESPWCFTLDPNVRVDLCDIPPC---NPPEKMKKELLYILIP---SVATPLVFACLFFLIC-MCRNKQKESVDTPTRRQLTASPSQEMELPLLNQ-HKHQAKLRELN----------LSAVRFMEELGEDRFGKVYKGHLYGTAPGE----QTQVVAIKTVKDKDEGPLREEFRHEAMLRSRLQHPNIVCLLGVITKEQPMSMIFSYSGQGDLHEFLVMRSPH-----SDVGSSDDDKTVKSTLEQADFLHIVTQVAAGMEYLSSHHVVHKDLAARNILVCDKLNVKILDLGLFREVYSADYYKLMGAS-PFPIRWMSPEAILYGKFSTDSDIWSYGVVLWEIFSYGLQPYCGYSNQDVIEMVRNRQVLSCPDDCPAWIYTMMLECWNEFPSRRPRFKDIHARLRTWE 752
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Match: musk (muscle, skeletal, receptor tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-030131-6458]) HSP 1 Score: 316.235 bits (809), Expect = 1.674e-92 Identity = 233/762 (30.58%), Postives = 358/762 (46.98%), Query Frame = 3
Query: 357 KLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGST-LKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLS-GHMVYVTHGRVQAE--KERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSED---QKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYL-VSVPKCEKLHNNQGCFRFNELPAVP-VKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIK----DHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGS---------CHSNGLTRKSYLG-IYKPCQNDCKKSESSLVQLNKIKI------------TSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSIS--TVPADSMDAYGD--VTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIH 2495
K+ K+ ++G ++TLEC+ +G P P+I+W L + + ++L G L + + YTCQA N + + + + GYC T++ C L +V+ + E +E S E+ V S C L CH F C+ P+ +C+E C V + C ++ ++ ++ + +++P+C L + Q + AVP V K CYN GR Y GT + T PC W +V ++ NYCRNP E D PWC+T+ R E C V +C + +PS + F + P +S + +I I+ G G+ CH K + + SE L +L+ + S +YP + I + IGEG FG V++A G P T +V VK L +S +Q +F++EA +MSE H N++ L+GV P CL+F++M GDL+E L + S+S T+ + S+ + + LS +Q+ I+ Q+A+GM YLS R FVHRDLA RN L+ ENL+ KI+D GL ++ Y++DYY+ + + +PIRWM PE+I + R+T ESDVWAYGV+LWEI+S G+QP+YG ++ EV+ VR +LSCP+NCP ++Y+LM CW+ P RP F +IH
Sbjct: 210 KILKVPKEKRVQIGSEVTLECNATGNPIPSITW----LENGNTISGASVVETLVGEVILSVLQVVVHKPALYTCQATNRHS--------------GGENTVKATAKITVSVFRLYKGHAGYCSTYRGDVCRNVLRRDALVFFNYSLPNPEDAQEYLAQSAWPELDGVSSF-----CRPAARSLLCHSTFQDCNPSGLGPAPKPVCREHCLTVKELYCYKEWRSAEERSQRGFQHITLPECTSLPSQQA--DPSSCTAVPYVDIKKDQVTSTCYNDKGRFYQGTHNVTASSIPCQRWNQQDPHQHRLSVDVIPELRNAENYCRNPGGE----SDRPWCYTTNPNVRWEYCLVPKCGEVISIRTAPSITKPAHF--YPPPSVSTAYSMSVIIFVIA----------GFAGAAFFTVLILMCHRRKKMWKKRKSRVLETPTLTTLPSELLLDRLHPNPMYQRLPLLLNSKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPTEPFT----MVAVKMLKEEASTDMQNDFQREAALMSEFDHPNIVRLLGVCAVGKPMCLMFEYMAYGDLNEFLRRRCATQQPSLSRDTLTSSSLVSEPERYPPLSCQEQLSISKQVAAGMAYLSERKFVHRDLATRNCLVAENLVVKIADFGLSRNIYAADYYKASEND-AIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRDGNVLSCPENCPQELYNLMRLCWSGHPTDRPSFASIH 925
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ROR1 (receptor tyrosine kinase-like orphan receptor 1 [Source:NCBI gene;Acc:100498561]) HSP 1 Score: 454.907 bits (1169), Expect = 3.643e-144 Identity = 274/788 (34.77%), Postives = 412/788 (52.28%), Query Frame = 3
Query: 255 IVYMVFLNQPISGFTAKDIKQTDSKQPPQFEGYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAEN------TFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ-----KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
++ + L + G+ A+DI YL+L++ + N+T +G+ L C +SG P PTI W K P+V +I R + +GS L+I +LD +D G++ C A N T G T + S+D GYCQ ++ +C +++ H +YV +Q E E +I + I + S +C + + CH F C E+ KPR LC+++CE + C Y ++L +LK +P CE L + C R +P+ T+P K + CYN TG +Y GTVS T G C W N + ++ ++YCRNP Q++APWCFT + E+C + C S + + +P S+ + ++ IC IC+ ++ ++ +P + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + +F+QEA +M+EL H N++ LVGV ++ P C++F+FM +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNIL+GE L KISD+GL ++ YSSDYYR +L LPIRWM PEAI +G+F+ +SD+W+YGV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECW E+P RP+FK+I R+R W+
Sbjct: 23 LLVLTLLEACLWGYRAEDI-------------YLQLDEPMNNITTSLGQTAELHCKVSGNPSPTIRWLKNDAPVVQEPRRISFRTTNYGSRLRIRNLDTTDTGYFQCVATNGRKTVSTTGVLFVKFGPPPTASPGSVD----------------DEEDGYCQPYRGIACARFILNHTIYVESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDENAPHSSPKPRDLCRDECEILENVLCQAEYIFARSNPMILMRLK------LPNCEDLPLPDSLEARNCIRI----GIPM-TEPINKNHKCYNNTGVDYRGTVSATKSGRQCQPWNSNHPHTHTFNAIRYPELNGGHSYCRNP----GNQREAPWCFTLDENVKYELCDIPACDSKDSKEKNKMEILYILVP---SVAIPLAIALLFFFIC-ICRNNQKASSPPAQR------------QPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWSDFQQEASLMTELHHPNIVCLVGVVTQEQPVCMLFEFMNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYRVQNKSL-LPIRWMPPEAILYGKFSTDSDIWSYGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWQEIPSRRPRFKDILVRLRTWE 736
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ROR1 (receptor tyrosine kinase-like orphan receptor 1 [Source:NCBI gene;Acc:100498561]) HSP 1 Score: 453.751 bits (1166), Expect = 4.011e-144 Identity = 271/759 (35.70%), Postives = 402/759 (52.96%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAEN------TFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ-----KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYI---SIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
YL+L++ + N+T +G+ L C +SG P PTI W K P+V +I R + +GS L+I +LD +D G++ C A N T G T + S+D GYCQ ++ +C +++ H +YV +Q E E +I + I + S +C + + CH F C E+ KPR LC+++CE + C Y ++L +LK +P CE L + C R +P+ T+P K + CYN TG +Y GTVS T G C W N + ++ ++YCRNP Q++APWCFT + E+C + C D+K +YI S+ + ++ IC IC+ ++ ++ +P + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + +F+QEA +M+EL H N++ LVGV ++ P C++F+FM +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNIL+GE L KISD+GL ++ YSSDYYR +L LPIRWM PEAI +G+F+ +SD+W+YGV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECW E+P RP+FK+I R+R W+
Sbjct: 10 YLQLDEPMNNITTSLGQTAELHCKVSGNPSPTIRWLKNDAPVVQEPRRISFRTTNYGSRLRIRNLDTTDTGYFQCVATNGRKTVSTTGVLFVKFGPPPTASPGSVD----------------DEEDGYCQPYRGIACARFILNHTIYVESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDENAPHSSPKPRDLCRDECEILENVLCQAEYIFARSNPMILMRLK------LPNCEDLPLPDSLEARNCIRI----GIPM-TEPINKNHKCYNNTGVDYRGTVSATKSGRQCQPWNSNHPHTHTFNAIRYPELNGGHSYCRNP----GNQREAPWCFTLDENVKYELCDIPAC------DSKDSKEKNKMEILYILVPSVAIPLAIALLFFFIC-ICRNNQKASSPPAQR------------QPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWSDFQQEASLMTELHHPNIVCLVGVVTQEQPVCMLFEFMNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYRVQNKSL-LPIRWMPPEAILYGKFSTDSDIWSYGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWQEIPSRRPRFKDILVRLRTWE 704
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ROR1 (receptor tyrosine kinase-like orphan receptor 1 [Source:NCBI gene;Acc:100498561]) HSP 1 Score: 453.366 bits (1165), Expect = 2.122e-143 Identity = 276/798 (34.59%), Postives = 417/798 (52.26%), Query Frame = 3
Query: 255 IVYMVFLNQPISGFTAKDIKQTDSKQPPQFEG-------YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAEN------TFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ-----KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYI---SIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
++ + L + G+ A+ + + + P + G YL+L++ + N+T +G+ L C +SG P PTI W K P+V +I R + +GS L+I +LD +D G++ C A N T G T + S+D GYCQ ++ +C +++ H +YV +Q E E +I + I + S +C + + CH F C E+ KPR LC+++CE + C Y ++L +LK +P CE L + C R +P+ T+P K + CYN TG +Y GTVS T G C W N + ++ ++YCRNP Q++APWCFT + E+C + C D+K +YI S+ + ++ IC IC+ ++ ++ +P + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + +F+QEA +M+EL H N++ LVGV ++ P C++F+FM +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNIL+GE L KISD+GL ++ YSSDYYR +L LPIRWM PEAI +G+F+ +SD+W+YGV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECW E+P RP+FK+I R+R W+
Sbjct: 23 LLVLTLLEACLWGYRAEAHGKGEQRCPMPYIGRLKKRDIYLQLDEPMNNITTSLGQTAELHCKVSGNPSPTIRWLKNDAPVVQEPRRISFRTTNYGSRLRIRNLDTTDTGYFQCVATNGRKTVSTTGVLFVKFGPPPTASPGSVD----------------DEEDGYCQPYRGIACARFILNHTIYVESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDENAPHSSPKPRDLCRDECEILENVLCQAEYIFARSNPMILMRLK------LPNCEDLPLPDSLEARNCIRI----GIPM-TEPINKNHKCYNNTGVDYRGTVSATKSGRQCQPWNSNHPHTHTFNAIRYPELNGGHSYCRNP----GNQREAPWCFTLDENVKYELCDIPAC------DSKDSKEKNKMEILYILVPSVAIPLAIALLFFFIC-ICRNNQKASSPPAQR------------QPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWSDFQQEASLMTELHHPNIVCLVGVVTQEQPVCMLFEFMNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYRVQNKSL-LPIRWMPPEAILYGKFSTDSDIWSYGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWQEIPSRRPRFKDILVRLRTWE 756
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ROR1 (receptor tyrosine kinase-like orphan receptor 1 [Source:NCBI gene;Acc:100498561]) HSP 1 Score: 452.981 bits (1164), Expect = 3.219e-143 Identity = 269/756 (35.58%), Postives = 401/756 (53.04%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAEN------TFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ-----KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
YL+L++ + N+T +G+ L C +SG P PTI W K P+V +I R + +GS L+I +LD +D G++ C A N T G T + S+D GYCQ ++ +C +++ H +YV +Q E E +I + I + S +C + + CH F C E+ KPR LC+++CE + C Y ++L +LK +P CE L + C R +P+ T+P K + CYN TG +Y GTVS T G C W N + ++ ++YCRNP Q++APWCFT + E+C + C S + + +P S+ + ++ IC IC+ ++ ++ +P + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + +F+QEA +M+EL H N++ LVGV ++ P C++F+FM +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNIL+GE L KISD+GL ++ YSSDYYR +L LPIRWM PEAI +G+F+ +SD+W+YGV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECW E+P RP+FK+I R+R W+
Sbjct: 66 YLQLDEPMNNITTSLGQTAELHCKVSGNPSPTIRWLKNDAPVVQEPRRISFRTTNYGSRLRIRNLDTTDTGYFQCVATNGRKTVSTTGVLFVKFGPPPTASPGSVD----------------DEEDGYCQPYRGIACARFILNHTIYVESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDENAPHSSPKPRDLCRDECEILENVLCQAEYIFARSNPMILMRLK------LPNCEDLPLPDSLEARNCIRI----GIPM-TEPINKNHKCYNNTGVDYRGTVSATKSGRQCQPWNSNHPHTHTFNAIRYPELNGGHSYCRNP----GNQREAPWCFTLDENVKYELCDIPACDSKDSKEKNKMEILYILVP---SVAIPLAIALLFFFIC-ICRNNQKASSPPAQR------------QPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWSDFQQEASLMTELHHPNIVCLVGVVTQEQPVCMLFEFMNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYRVQNKSL-LPIRWMPPEAILYGKFSTDSDIWSYGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWQEIPSRRPRFKDILVRLRTWE 760
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Match: ROR1 (receptor tyrosine kinase-like orphan receptor 1 [Source:NCBI gene;Acc:100498561]) HSP 1 Score: 452.595 bits (1163), Expect = 7.584e-143 Identity = 271/759 (35.70%), Postives = 402/759 (52.96%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAEN------TFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ-----KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYI---SIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
YL+L++ + N+T +G+ L C +SG P PTI W K P+V +I R + +GS L+I +LD +D G++ C A N T G T + S+D GYCQ ++ +C +++ H +YV +Q E E +I + I + S +C + + CH F C E+ KPR LC+++CE + C Y ++L +LK +P CE L + C R +P+ T+P K + CYN TG +Y GTVS T G C W N + ++ ++YCRNP Q++APWCFT + E+C + C D+K +YI S+ + ++ IC IC+ ++ ++ +P + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + +F+QEA +M+EL H N++ LVGV ++ P C++F+FM +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNIL+GE L KISD+GL ++ YSSDYYR +L LPIRWM PEAI +G+F+ +SD+W+YGV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECW E+P RP+FK+I R+R W+
Sbjct: 86 YLQLDEPMNNITTSLGQTAELHCKVSGNPSPTIRWLKNDAPVVQEPRRISFRTTNYGSRLRIRNLDTTDTGYFQCVATNGRKTVSTTGVLFVKFGPPPTASPGSVD----------------DEEDGYCQPYRGIACARFILNHTIYVESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDENAPHSSPKPRDLCRDECEILENVLCQAEYIFARSNPMILMRLK------LPNCEDLPLPDSLEARNCIRI----GIPM-TEPINKNHKCYNNTGVDYRGTVSATKSGRQCQPWNSNHPHTHTFNAIRYPELNGGHSYCRNP----GNQREAPWCFTLDENVKYELCDIPAC------DSKDSKEKNKMEILYILVPSVAIPLAIALLFFFIC-ICRNNQKASSPPAQR------------QPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWSDFQQEASLMTELHHPNIVCLVGVVTQEQPVCMLFEFMNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYRVQNKSL-LPIRWMPPEAILYGKFSTDSDIWSYGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWQEIPSRRPRFKDILVRLRTWE 780
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Ror1 (receptor tyrosine kinase-like orphan receptor 1 [Source:MGI Symbol;Acc:MGI:1347520]) HSP 1 Score: 442.965 bits (1138), Expect = 1.328e-139 Identity = 268/754 (35.54%), Postives = 397/754 (52.65%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAEN------TFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ---KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFT-SVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
YL L++ + N+T +G+ L C +SG P P+I W K P+V +I R + +GS L+I +LD +D G++ C A N T G T + S D+ G+CQ ++ +C +++ VY+ +Q E E +I + I + S +C + + CH F C E KPR LC+++CE + C Y ++L +LK +P CE L + C R A P+ K + CYN TG +Y GTVS T G C W + F ++ ++YCRNP Q++APWCFT ++C + C S + + +P ++I I F+ I +C +KS S + R+ KP + + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + EF+QEA +M+EL H N++ L+G ++ P C++F++M +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNILIGE L KISD+GL ++ YS+DYYR S LPIRWM PEAI +G+F+ +SD+W++GV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECWNE+P RP+FK+IH R+R W+
Sbjct: 57 YLTLDEPMNNITTSLGQTAELHCKVSGNPPPSIRWFKNDAPVVQEPRRISFRATNYGSRLRIRNLDTTDTGYFQCVATNGKKVVSTTGVLFVKFGPPPTASPGSSDEY---------------EEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEVLENVLCQTEYIFARSNPMILMRLK------LPNCEDLPQPESPEAANCIRIGIPMADPIN-----KNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFTALRFPELNGGHSYCRNP----GNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPS-VAIPLAIAFLFFFICVCRNNQKSS--------SPPVQRQP-----KPVRG--QNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECTFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQ-SKSSLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWE 750
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Ror2 (receptor tyrosine kinase-like orphan receptor 2 [Source:MGI Symbol;Acc:MGI:1347521]) HSP 1 Score: 424.476 bits (1090), Expect = 1.106e-132 Identity = 253/745 (33.96%), Postives = 384/745 (51.54%), Query Frame = 3
Query: 336 PQFEGY-LKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMC---SEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
P +GY L + + N+T G+ L C ++G P P + W K P+V ++ IR++ +GS L+I+DLD +D G+Y C A N T + V + ++ + G+CQ ++ +C +++ +YV ++Q E E RI + I + S Q +C + + CH F +C S KPR LC+++CE + C Y + + +PKCE L + C R +PA + + + CYNG+G +Y G S T G C W + F ++ + YCRNP Q + PWCFT R E+C V C SP L I+I VI + + +C +K+ T R+ + P Q+ E L+ +K + + LS +RF E++GE FG VYK L G P + V +KTL + L+ EF+QEA + + L+H N++ L+GV + P +IF + GDLHE L+ + S V + D L D + + AQIA+GME+LSS VH+DLA RN+L+ + L +ISD+GL ++ YS+DYY+ G++L LPIRWMSPEA+ +G+F+++SD+W+YGV+LWE++S GLQP+ G+SN +V+E++RSRQ+L CPD+CP VY LM+ECWNE P RP+FK+IHSR+R W
Sbjct: 43 PTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTH---------SPNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGT--STQLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIG-IPAERLG-----RYHQCYNGSGADYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNP----GGQVEGPWCFTQNKNVRVELCDVPPC----SPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTP--------QRRQLMA--SPSQD----MEMPLISQHK-QAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEP----TQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPH-----SDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSL-LPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRSW 737
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Ror2 (receptor tyrosine kinase-like orphan receptor 2 [Source:MGI Symbol;Acc:MGI:1347521]) HSP 1 Score: 424.476 bits (1090), Expect = 1.727e-132 Identity = 253/745 (33.96%), Postives = 384/745 (51.54%), Query Frame = 3
Query: 336 PQFEGY-LKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMC---SEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
P +GY L + + N+T G+ L C ++G P P + W K P+V ++ IR++ +GS L+I+DLD +D G+Y C A N T + V + ++ + G+CQ ++ +C +++ +YV ++Q E E RI + I + S Q +C + + CH F +C S KPR LC+++CE + C Y + + +PKCE L + C R +PA + + + CYNG+G +Y G S T G C W + F ++ + YCRNP Q + PWCFT R E+C V C SP L I+I VI + + +C +K+ T R+ + P Q+ E L+ +K + + LS +RF E++GE FG VYK L G P + V +KTL + L+ EF+QEA + + L+H N++ L+GV + P +IF + GDLHE L+ + S V + D L D + + AQIA+GME+LSS VH+DLA RN+L+ + L +ISD+GL ++ YS+DYY+ G++L LPIRWMSPEA+ +G+F+++SD+W+YGV+LWE++S GLQP+ G+SN +V+E++RSRQ+L CPD+CP VY LM+ECWNE P RP+FK+IHSR+R W
Sbjct: 55 PTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTH---------SPNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGT--STQLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIG-IPAERLG-----RYHQCYNGSGADYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNP----GGQVEGPWCFTQNKNVRVELCDVPPC----SPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTP--------QRRQLMA--SPSQD----MEMPLISQHK-QAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEP----TQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPH-----SDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSL-LPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRSW 749
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Musk (muscle, skeletal, receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:103581]) HSP 1 Score: 271.937 bits (694), Expect = 3.610e-77 Identity = 158/418 (37.80%), Postives = 241/418 (57.66%), Query Frame = 3
Query: 1281 EPTQQQDAPW-CFTSVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIG-FVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADS---MDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQ 2519
+PT P+ F S+T +R + + + SF+ + ++ + V ISI F ++TI+ + C++ K N S +T + + + L K+ S +YP + I + IGEG FG V++A G P T +V VK L +S +Q +F++EA +M+E + N++ L+GV P CL+F++M GDL+E L S + V S+S + + + G LS +Q+ IA Q+A+GM YLS R FVHRDLA RN L+GE ++ KI+D GL ++ YS+DYY+ G+ +PIRWM PE+I + R+T ESDVWAYGV+LWEI+S GLQP+YG ++ EV+ VR IL+CP+NCP ++Y+LM CW+++P RP F +IH R+ Q+
Sbjct: 453 DPTACTRLPYLAFPSITSSRPSADIPN-LPASTSSFAVSPAYS--MTVIISIVSSFALFALLTIATLYCCRRRKEWKNKKRESTAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFT----MVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGND-AIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIH---RILQR 859
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Match: Musk (muscle, skeletal, receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:103581]) HSP 1 Score: 271.937 bits (694), Expect = 4.129e-77 Identity = 166/459 (36.17%), Postives = 254/459 (55.34%), Query Frame = 3
Query: 1158 GREYVGTVSQTIHGTPCVTWKNVPGFEDMVADNNYC-RNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIG-FVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADS---MDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQ 2519
G+ + G +H P +P M D C R P L+ ++ F S+T +R + + + SF+ + ++ + V ISI F ++TI+ + C++ K N S +T + + + L K+ S +YP + I + IGEG FG V++A G P T +V VK L +S +Q +F++EA +M+E + N++ L+GV P CL+F++M GDL+E L S + V S+S + + + G LS +Q+ IA Q+A+GM YLS R FVHRDLA RN L+GE ++ KI+D GL ++ YS+DYY+ G+ +PIRWM PE+I + R+T ESDVWAYGV+LWEI+S GLQP+YG ++ EV+ VR IL+CP+NCP ++Y+LM CW+++P RP F +IH R+ Q+
Sbjct: 425 GKAHRGLYRSGMHLLPVPECSKLPS---MHRDPTACTRLPYLDYKKENIT--TFPSITSSRPSADIPN-LPASTSSFAVSPAYS--MTVIISIVSSFALFALLTIATLYCCRRRKEWKNKKRESTAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFT----MVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGND-AIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIH---RILQR 867
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|Q9Z139|ROR1_MOUSE (Inactive tyrosine-protein kinase transmembrane receptor ROR1 OS=Mus musculus OX=10090 GN=Ror1 PE=2 SV=2) HSP 1 Score: 442.965 bits (1138), Expect = 9.291e-139 Identity = 268/754 (35.54%), Postives = 397/754 (52.65%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAEN------TFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ---KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFT-SVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
YL L++ + N+T +G+ L C +SG P P+I W K P+V +I R + +GS L+I +LD +D G++ C A N T G T + S D+ G+CQ ++ +C +++ VY+ +Q E E +I + I + S +C + + CH F C E KPR LC+++CE + C Y ++L +LK +P CE L + C R A P+ K + CYN TG +Y GTVS T G C W + F ++ ++YCRNP Q++APWCFT ++C + C S + + +P ++I I F+ I +C +KS S + R+ KP + + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + EF+QEA +M+EL H N++ L+G ++ P C++F++M +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNILIGE L KISD+GL ++ YS+DYYR S LPIRWM PEAI +G+F+ +SD+W++GV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECWNE+P RP+FK+IH R+R W+
Sbjct: 57 YLTLDEPMNNITTSLGQTAELHCKVSGNPPPSIRWFKNDAPVVQEPRRISFRATNYGSRLRIRNLDTTDTGYFQCVATNGKKVVSTTGVLFVKFGPPPTASPGSSDEY---------------EEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEVLENVLCQTEYIFARSNPMILMRLK------LPNCEDLPQPESPEAANCIRIGIPMADPIN-----KNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHSFTALRFPELNGGHSYCRNP----GNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPS-VAIPLAIAFLFFFICVCRNNQKSS--------SPPVQRQP-----KPVRG--QNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECTFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYMNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQ-SKSSLPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWE 750
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|Q01973|ROR1_HUMAN (Inactive tyrosine-protein kinase transmembrane receptor ROR1 OS=Homo sapiens OX=9606 GN=ROR1 PE=1 SV=2) HSP 1 Score: 441.425 bits (1134), Expect = 2.980e-138 Identity = 264/753 (35.06%), Postives = 397/753 (52.72%), Query Frame = 3
Query: 345 EGYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXS---RSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ---KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFT-SVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+ YL L++ + N+T +G+ L C +SG P PTI W K P+V ++ R +++GS L+I +LD +D G++ C A N + SS + V+ S G+CQ ++ +C +++ VY+ +Q E E +I + I + S +C + + CH F C E KPR LC+++CE + C Y ++L +LK +P CE L + C R A P+ K + CYN TG +Y GTVS T G C W + F ++ ++YCRNP Q++APWCFT ++C + C S + + +P ++I I + I +C +KS S + R+ P + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL ++ + EF+QEA +M+EL H N++ L+G ++ P C++F+++ +GDLHE LI +RS + S D G V +L + D + IA QIA+GMEYLSS FVH+DLAARNILIGE L KISD+GL ++ YS+DYYR +L LPIRWM PEAI +G+F+ +SD+W++GV+LWEI+S GLQP+YG SN EV+E+VR RQ+L C ++CP ++Y LM ECWNE+P RP+FK+IH R+R W+
Sbjct: 55 DSYLTLDEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDTTDTGYFQCVATNG------------KEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIGNRTVYMESLHMQGEIENQITAAFTMIGT--SSHLSDKCSQFAIPSLCHYAFPYCDETSSVPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLK------LPNCEDLPQPESPEAANCIRIGIPMADPIN-----KNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCRNP----GNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPS-VAIPLAIALLFFFICVCRNNQKSS--------SAPVQRQ-------PKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGAVTQEQPVCMLFEYINQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAAGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSL-LPIRWMPPEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRMYSLMTECWNEIPSRRPRFKDIHVRLRSWE 750
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|Q9Z138|ROR2_MOUSE (Tyrosine-protein kinase transmembrane receptor ROR2 OS=Mus musculus OX=10090 GN=Ror2 PE=1 SV=2) HSP 1 Score: 424.476 bits (1090), Expect = 1.208e-131 Identity = 253/745 (33.96%), Postives = 384/745 (51.54%), Query Frame = 3
Query: 336 PQFEGY-LKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMC---SEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
P +GY L + + N+T G+ L C ++G P P + W K P+V ++ IR++ +GS L+I+DLD +D G+Y C A N T + V + ++ + G+CQ ++ +C +++ +YV ++Q E E RI + I + S Q +C + + CH F +C S KPR LC+++CE + C Y + + +PKCE L + C R +PA + + + CYNG+G +Y G S T G C W + F ++ + YCRNP Q + PWCFT R E+C V C SP L I+I VI + + +C +K+ T R+ + P Q+ E L+ +K + + LS +RF E++GE FG VYK L G P + V +KTL + L+ EF+QEA + + L+H N++ L+GV + P +IF + GDLHE L+ + S V + D L D + + AQIA+GME+LSS VH+DLA RN+L+ + L +ISD+GL ++ YS+DYY+ G++L LPIRWMSPEA+ +G+F+++SD+W+YGV+LWE++S GLQP+ G+SN +V+E++RSRQ+L CPD+CP VY LM+ECWNE P RP+FK+IHSR+R W
Sbjct: 55 PTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRVIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGLKTITATGVLYVRLGPTH---------SPNHNFQDDDQEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGT--STQLSDQCSQFAIPSFCHFVFPLCDARSRAPKPRELCRDECEVLENDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIG-IPAERLG-----RYHQCYNGSGADYRGMASTTKSGHQCQPWALQHPHSHRLSSTEFPELGGGHAYCRNP----GGQVEGPWCFTQNKNVRVELCDVPPC----SPRDGSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTP--------QRRQLMA--SPSQD----MEMPLISQHK-QAKLKEISLSTVRFMEELGEDRFGKVYKGHLFGPAPGEP----TQAVAIKTLKDKAEGPLREEFRQEAMLRARLQHPNIVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPH-----SDVGSTDDDRTVKSALEPPDFVHVVAQIAAGMEFLSSHHVVHKDLATRNVLVYDKLNVRISDLGLFREVYSADYYKLMGNSL-LPIRWMSPEAVMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRSRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRSW 749
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|Q01974|ROR2_HUMAN (Tyrosine-protein kinase transmembrane receptor ROR2 OS=Homo sapiens OX=9606 GN=ROR2 PE=1 SV=2) HSP 1 Score: 423.705 bits (1088), Expect = 1.737e-131 Identity = 256/746 (34.32%), Postives = 384/746 (51.47%), Query Frame = 3
Query: 336 PQFEGY-LKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMC---SEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK---------NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITG-NSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
P +GY L + + N+T G+ L C ++G P P + W K P+V +I IR++ +GS L+I+DLD +D G+Y C A N T + V + ++ G+CQ ++ +C +++ +YV ++Q E E RI + I + S +C + + CH F +C S KPR LC+++CE + C Y + + +PKCE L + C R +PA + + + CYNG+G +Y GT S T G C W + F ++ + YCRNP Q + PWCFT R E+C V C SP S L I+I VI + + +C +K+ T R+ + P Q+ E L+ +K + + LS +RF E++GE FG VYK L G P G + V +KTL + L+ EF+ EA + + L+H NV+ L+GV + P +IF + GDLHE L+ + S V + D L D + + AQIA+GMEYLSS VH+DLA RN+L+ + L KISD+GL ++ Y++DYY+ G++L LPIRWM+PEAI +G+F+++SD+W+YGV+LWE++S GLQP+ G+SN +V+E++R+RQ+L CPD+CP VY LM+ECWNE P RP+FK+IHSR+R W
Sbjct: 55 PTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTH---------SPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGT--STHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIG-IPAERLG-----RYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNP----GGQMEGPWCFTQNKNVRMELCDVPSC----SPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTP--------QRRQLMA--SPSQD----MEMPLINQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFG-----PAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPH-----SDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSL-LPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAW 749
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Match: sp|Q8AXY6|MUSK_CHICK (Muscle, skeletal receptor tyrosine protein kinase OS=Gallus gallus OX=9031 GN=MUSK PE=2 SV=1) HSP 1 Score: 315.079 bits (806), Expect = 4.315e-91 Identity = 234/746 (31.37%), Postives = 356/746 (47.72%), Query Frame = 3
Query: 396 GKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGH-MVYVTHGRVQAEKERRIASLVA--EISSVLSQQADQECLKHIMRLTCHDNFLMCSED---QKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKD------YLVSVPKCEKLHN-NQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTW--------KNVPG-FEDMVADNNYCRNPRLEPTQQQDAPWCFT---SVTGNREVCSVRQCIKDHSPSFSDNK-----------------SFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYG----DVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIH 2495
G +TL C +G P PT++W + + + ++ + S L++ + G +TC A N T A T + S K+ GYC T++ C LS + +V+ E+ + + A E+ +V S C L C+ F C P+ +C+E+C V C + M + ++ L+++P+C +L + +Q +P K + + CY+G G+ Y G + T G PC W + P F ++ NYCRNP E + PWC+T SVT E CSV C D S S K N + + IS +I VI+ I C++ K N S T + + + L K+ S +YP + I + IGEG FG V++A G P T +V VK L +S +Q +F++EA +M+E + N++ L+GV P CL+F++M GDL+E L + R++ ++ ++A + L T Q+ IA Q+A+GM YLS R FVHRDLA RN L+GEN++ KI+D GL ++ YS+DYY+ + +PIRWM PE+I + R+T ESDVWAYGV+LWEI+S G+QP+YG ++ EV+ VR ILSCPDNCP ++Y+LM CW+++P RP F +IH
Sbjct: 226 GSMVTLRCTAAGAPVPTVTWLENGKAVSAGSIAESVKDRVVDSRLQVY---VTRPGLFTCLATNKHSKTFGAAKAAATISVSEWSKL-------------YKGDAGYCSTYRGEVCSAILSRNALVFFNSSYADPEETQELLVHTAWTELKTVSSF-----CQPAAESLLCNYIFQECKPSGVGPAPKPICRENCLAVKDLYCFKEWLSMEENSQRGIYKPGLMLLALPECNRLPSLHQDPSACTHIPFFDFKKENITR--TCYSGNGQFYQGWANVTASGIPCQKWSDQAPHLHRRTPQVFPELSDAENYCRNPGGE----NERPWCYTKDPSVTW--EYCSVSPC-GDASLSLGTRKPNGETQNLPPPPSYSPTYSMNVIILIISSFALI--VILGIITLVCCRRRKQWKNKKRESETPTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFT----MVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEYLRDRSP---RNLCSLVQGGLEARACLLNPLALCCTSQLCIAKQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNMYSADYYKANEND-AIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGMQPYYGMAHEEVIYYVRDGNILSCPDNCPLELYNLMRLCWSKLPADRPSFASIH 931
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A1S6KMI9 (Uncharacterized protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 1716.05 bits (4443), Expect = 0.000e+0 Identity = 867/868 (99.88%), Postives = 868/868 (100.00%), Query Frame = 3
Query: 222 MLKCSKKLLIIIVYMVFLNQPISGFTAKDIKQTDSKQPPQFEGYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKNVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDVEINPNCIGAGSARXXXXXXXXXXXXXXXEMCSDHSHLLTGYSPATCQTNQDPSTNGIVNNITFNQQFDPPSLLSQSGPMHFSRLPNTNTIYLPELSHIV 2825
MLKCSKKLLIIIVYMVFLNQPISGFTAKDIKQTDSKQPPQFEGY+KLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGYTNTTAYVTVTKTKSSIDKIPVENEEEEFIENEESRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKNVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDVEINPNCIGAGSARSVSHSGGSKHTTSSTEMCSDHSHLLTGYSPATCQTNQDPSTNGIVNNITFNQQFDPPSLLSQSGPMHFSRLPNTNTIYLPELSHIV
Sbjct: 1 MLKCSKKLLIIIVYMVFLNQPISGFTAKDIKQTDSKQPPQFEGYIKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGYTNTTAYVTVTKTKSSIDKIPVENEEEEFIENEESRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKNVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDVEINPNCIGAGSARSVSHSGGSKHTTSSTEMCSDHSHLLTGYSPATCQTNQDPSTNGIVNNITFNQQFDPPSLLSQSGPMHFSRLPNTNTIYLPELSHIV 868
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A1B1M0P6 (Tyrosine-protein kinase receptor OS=Platynereis dumerilii OX=6359 PE=2 SV=1) HSP 1 Score: 462.225 bits (1188), Expect = 2.366e-143 Identity = 274/777 (35.26%), Postives = 421/777 (54.18%), Query Frame = 3
Query: 348 GYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLV-DINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDK------IPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQK----PRRLCQEDCEDVTKKRCNYTY-KLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKNVPGFEDMV--------ADNNYCRNPRLEPTQQQDAPWCFTSVT------------GNREVCS--------VRQCIKD-------HSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQE 2522
G+++LN + N T G + ++CDISG P P W K + + D + + + + WGS L+I D+ D G YTC+ N +G + Y+ V ++ K ++EEE E S G+CQ ++ ++C K+L+ ++V Q E E ++ + V I++ S Q C +H+++ C F C + P+++C+++CE + C Y K + LV +P C+ L + C R +P + Y CYN TG+ Y GTVS T+ G C W ++ + ++N+CRNP ++ APWCFT+ GN+ CS C+++ H P+ +D + L + I I ++ IC ICKK+K G +KP ++ E + + K+ + + ++P+SQ+RF +++GEG FG VYK EL+G P + S V VKTL +S K+Q +F++E +M++LKH N++ L+GV ++ P ++F++M +GDLHE L +RS + + S D L + + + IA QIA+GMEYLSS FVHRDLAARN+L+G+NL KISD GL +D YSSDYYR +L LP+RWM+PE+I FG+FTVESDVW++GV+LWEI+S GLQP+YG+SN EV+E++R+RQIL CP++CP+++Y LM+ CWNEM RP FK+IH R+R+W E
Sbjct: 38 GHVQLNADMRNYTKYSGDTVRIDCDISGNPTPQYRWYKENVAISEDGDRRFHAKATHWGSRLRISDVTPMDSGQYTCEGFNQYGVQRVSGYLRVRSERNPNQKPDSGKDQDEDDEEENDPGYELHESGGFCQPYRGAACSKFLNDRSIFVMSKVQQGEMEGKLTAAVTVIAT--SSDLSQRCGEHVIKSLCFYAFPQCGQAMDGRAIPKKICRDECEILQNDLCRTEYLKAKTHPILGSQLV-LPDCQTLPPVGSPAARDCVRI----GIPTPKASNERHY-CYNSTGQTYRGTVSTTLSGYRCQKWTDMYPHHHFLTTANNPELGNHNFCRNP----GNREAAPWCFTTNDKVRTELCEIPKCGNQVDCSTFPAGSAAAENCLRNGIPPKASHEPAATDEGMKKILLILVPCIAVPIALALLLTIIC-ICKKTK---------------QVNGQHKPLGRPGQQLEMAAMTA-KMPLRAREFPISQVRFIQELGEGAFGKVYKGELLGY----PTENSISKVAVKTLKENASAKIQSDFRREVDLMTDLKHPNIVCLIGVCMKDEPMAMLFEYMSEGDLHEYLC------MRSPHSDVSVSDDEGASQVLDHGEMLHIAIQIAAGMEYLSSHHFVHRDLAARNVLVGDNLTVKISDFGLSRDVYSSDYYRVQSKSL-LPVRWMAPESILFGKFTVESDVWSFGVVLWEIYSFGLQPYYGYSNPEVIEMIRARQILPCPEDCPSRIYSLMVVCWNEMLTRRPSFKDIHQRLRMWMME 774
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A4W5REF5 (Receptor tyrosine kinase-like orphan receptor 1 OS=Hucho hucho OX=62062 PE=3 SV=1) HSP 1 Score: 458.373 bits (1178), Expect = 1.582e-142 Identity = 269/751 (35.82%), Postives = 406/751 (54.06%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ---KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYI---SIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+L+L + N+T +G+ L C +SG P PT+ W K P+V +I R + +GS L+I +LD +D G++ C A N++G +TT + + +P+ S +KG+CQ ++ +C +++ ++V ++Q E E +I + I + S C + + CH F C KPR LC+++CE + C Y ++L++LK +P CE L + C R +PV +P K + C+N +G Y GTVS+T G C W + + ++ ++YCRN P +Q+ PWCFT G R E+C + C + +N+ N +YI S+ + ++ IC +C+ ++ R KP + + E S++ K K + + PLS +RF E++GE FG +YK L P + +V +KTL SS GEF+QEA +M+EL H NV+ L+GV ++ P C++F+F+ +GDLHE LI +RS + S D G V +L + D + +A Q+A+GMEYL+S FVH+DLAARNIL+GE L KISD+GL ++ Y+SDYYR L LPIRWM PE+IA+G+FT ESD+WA+GV+LWEI+S GLQP+YG SN EVME+VR RQ+L CP++CP +V+ LM ECW E P RP+FK+IH R+R W+
Sbjct: 18 FLRLEAPMNNITTSLGQTAELLCRVSGNPLPTVRWLKNDAPVVQEPRRISYRPTPYGSRLRIRNLDTTDTGYFQCVATNSYGTVSTTGVLF-------VKFVPM------------SMNKGFCQPYRGVACSRFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNHLSDRCSQFAIPSLCHFAFPTCDRSSGVDKPRDLCKDECEILENDLCKTEYIIARSNPIILKRLK------LPNCEDLAAHDSPEAAICMRI----GIPV-AEPINKNHKCFNSSGSAYRGTVSKTKSGRQCQPWNSQYPHSHTYLAVSYPELSGGHSYCRN----PGNKQEGPWCFTLDEGVRMELCDIPIC------DYKENRGGSNMEILYILVPSVAIPLAIALLFFFIC-VCRNNQKA----------ARPPAPRQPKPVRG--QNVEMSMLTNYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMEQAQLVAIKTLKDYSSPGQWGEFQQEASVMAELHHPNVVCLLGVVTQEQPVCMLFEFLNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHLALQVAAGMEYLASHFFVHKDLAARNILVGEQLHVKISDLGLSREIYTSDYYRVQPKAL-LPIRWMPPESIAYGKFTSESDIWAFGVVLWEIFSYGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRVFGLMTECWQEGPTRRPRFKDIHGRLRAWE 701
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A4W5RQJ1 (Receptor tyrosine kinase-like orphan receptor 1 OS=Hucho hucho OX=62062 PE=3 SV=1) HSP 1 Score: 456.447 bits (1173), Expect = 1.205e-141 Identity = 267/751 (35.55%), Postives = 404/751 (53.79%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ---KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYI---SIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+L+L + N+T +G+ L C +SG P PT+ W K P+V +I R + +GS L+I +LD +D G++ C A N++G +TT + + P+ + +G+CQ ++ +C +++ ++V ++Q E E +I + I + S C + + CH F C KPR LC+++CE + C Y ++L++LK +P CE L + C R +PV +P K + C+N +G Y GTVS+T G C W + + ++ ++YCRNP +Q+ PWCFT G R E+C + C + +N+ N +YI S+ + ++ IC +C+ ++ R KP + + E S++ K K + + PLS +RF E++GE FG +YK L P + +V +KTL SS GEF+QEA +M+EL H NV+ L+GV ++ P C++F+F+ +GDLHE LI +RS + S D G V +L + D + +A Q+A+GMEYL+S FVH+DLAARNIL+GE L KISD+GL ++ Y+SDYYR L LPIRWM PE+IA+G+FT ESD+WA+GV+LWEI+S GLQP+YG SN EVME+VR RQ+L CP++CP +V+ LM ECW E P RP+FK+IH R+R W+
Sbjct: 18 FLRLEAPMNNITTSLGQTAELLCRVSGNPLPTVRWLKNDAPVVQEPRRISYRPTPYGSRLRIRNLDTTDTGYFQCVATNSYGTVSTTGVLF-------VKFDPLLTPLPGRPSANDFDEEGFCQPYRGVACSRFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNHLSDRCSQFAIPSLCHFAFPTCDRSSGVDKPRDLCKDECEILENDLCKTEYIIARSNPIILKRLK------LPNCEDLAAHDSPEAAICMRI----GIPV-AEPINKNHKCFNSSGSAYRGTVSKTKSGRQCQPWNSQYPHSHTYLAVSYPELSGGHSYCRNP----GNKQEGPWCFTLDEGVRMELCDIPIC------DYKENRGGSNMEILYILVPSVAIPLAIALLFFFIC-VCRNNQKAA----------RPPAPRQPKPVRG--QNVEMSMLTNYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMEQAQLVAIKTLKDYSSPGQWGEFQQEASVMAELHHPNVVCLLGVVTQEQPVCMLFEFLNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHLALQVAAGMEYLASHFFVHKDLAARNILVGEQLHVKISDLGLSREIYTSDYYRVQPKAL-LPIRWMPPESIAYGKFTSESDIWAFGVVLWEIFSYGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRVFGLMTECWQEGPTRRPRFKDIHGRLRAWE 713
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Match: A0A1S3P9H9 (tyrosine-protein kinase transmembrane receptor ROR1-like isoform X4 OS=Salmo salar OX=8030 GN=LOC106584030 PE=3 SV=1) HSP 1 Score: 455.292 bits (1170), Expect = 2.869e-141 Identity = 266/751 (35.42%), Postives = 404/751 (53.79%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSED---QKPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYI---SIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+L+L+ + N+T +G+ L C +SG P PT+ W K P+V +I R + +GS L+I +LD +D G++ C A N++G +TT + + P+ ++ +G+CQ ++ +C +++ ++V ++Q E E +I + I + S C + + CH F C KPR LC+++CE + C Y ++L++LK +P CE L + C R A P+ K + C+N +G Y GTVS+T G C W + + ++ ++YCRNP +Q+ PWCFT G R E+C + C + +N+ N +YI S+ + ++ IC +C+ ++ R KP + + E S++ K K + + PLS +RF E++GE FG +YK L P + +V +KTL SS GEF+QEA +M+EL H NV+ L+GV ++ P C++F+F+ +GDLHE LI +RS + S D G V +L + D + +A Q+A+GMEYL+S FVH+DLAARNIL+GE L KISD+GL ++ Y+SDYYR L LPIRWM PE+IA+G+FT ESD+WA+GV+LWEI+S GLQP+YG SN EVME+VR RQ+L CP++CP +V+ LM ECW E P RP+FK+IH R+R W+
Sbjct: 12 FLRLDAPMNNITTSLGQTAELLCRVSGNPLPTVRWLKNDAPVVQEPRRISFRPTPYGSRLRIRNLDTTDTGYFQCVATNSYGTVSTTGVLF-------VKFDPLLTPLPGRPSADDFDEEGFCQPYRGVACSRFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNHLSDRCSQFAIPSLCHFAFPTCDRSSGVDKPRDLCKDECEILENDLCKTEYIIARSNPIILKRLK------LPNCEDLAAHDSPEAAICMRIGIPMAEPID-----KNHKCFNSSGSAYRGTVSKTRSGRQCQPWNSQYPHSHTYLALRYPELSGGHSYCRNP----GNKQEGPWCFTLDEGVRMELCDIPIC------DYKENRGGSNMEILYILVPSVAIPLAIALLFFFIC-VCRNNQKAA----------RPPAPRQPKPVRG--QNVEMSMLTNYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMEQAQLVAIKTLKDYSSPGQWGEFQQEASVMAELHHPNVVCLLGVVTQEQPVCMLFEFLNQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHLALQVAAGMEYLASHFFVHKDLAARNILVGEQLHVKISDLGLSREIYTSDYYRVQPKAL-LPIRWMPPESIAYGKFTSESDIWAFGVVLWEIFSYGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRVFGLMTECWQEGPTRRPRFKDIHGRLRAWE 707
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: ror1 (receptor tyrosine kinase-like orphan receptor 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6104]) HSP 1 Score: 450.669 bits (1158), Expect = 3.113e-143 Identity = 265/741 (35.76%), Postives = 400/741 (53.98%), Query Frame = 3
Query: 372 LTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSED---QKPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+ N+T +G+ L C +SG P PT+ W K P+ ++ +Q+ +GS L+I +LD +D G++ C A N++G +TT + V D +P ++ + +G+CQ ++ +C +++ ++V ++Q E E +I + I + S C + + CH F C KPR LC+++CE + C Y ++L++LK +P CE L + C R A + K + C+N +G +Y GT S T G C W + + ++ ++YCRNP + +APWCFT R E+C + QC D + L ++I IG + I +C +K+ +R KP + + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL SS + G+F+QEA +++EL H NV+ L+GV ++ P C++F+F+ GDLHE LI +RS + S D G V +L + D + +A Q+A+GMEYLS R FVH+DLAARNIL+GE L KISD+GL ++ YSSDYYR +TL LPIRWMSPEAIA+G+FT +SD+WA+GV+LWEI+S GLQPFYG SN EVME+VR RQ+L CP++CP ++Y LM ECW E P RP+FK+IH+R+R W+
Sbjct: 1 MNNITTSLGQTAELHCHVSGNPPPTVRWLKNDAPVAPEARRVSYKQTQYGSRLRIRNLDTTDTGYFQCVATNSYGTVSTTGILFV-----KFDPLPTPQSGRPSPDDFDE--EGFCQPYRGIACARFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNHLSDRCSQFAIPSLCHFAFPTCDRSSGIDKPRDLCKDECEILENDLCKTEYIIARSNPIILKRLK------LPNCEDLAASDSPEAANCMRIGIPMAESIN-----KNHKCFNSSGADYRGTTSVTKSGRQCQPWNSQYPHSHNFLALRYPELNGGHSYCRNP----GNKHEAPWCFTLDDSVRMELCGIPQC--DSKEQRGGSVQILYILVPSVAIPLAIGLLFFFICVCRNNQKA-------------SRPPAQRQPKPVRG--QNVEMSMLPAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMEHAQLVAIKTLKDFSSAQQWGDFQQEASVLTELHHPNVVCLLGVVTQEQPVCMLFEFLALGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHLATQVAAGMEYLSGRFFVHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYRVQPNTL-LPIRWMSPEAIAYGKFTTDSDIWAFGVVLWEIFSFGLQPFYGFSNQEVMEMVRKRQLLPCPEDCPPRMYALMTECWQEGPARRPRFKDIHARLRAWE 688
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: ror1 (receptor tyrosine kinase-like orphan receptor 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6104]) HSP 1 Score: 450.284 bits (1157), Expect = 3.316e-143 Identity = 264/741 (35.63%), Postives = 397/741 (53.58%), Query Frame = 3
Query: 372 LTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQ---KPRRLCQEDCEDVTKKRCNYTY------KLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+ N+T +G+ L C +SG P PT+ W K P+ ++ +Q+ +GS L+I +LD +D G++ C A N++G +TT + + + V + N +G+CQ ++ +C +++ ++V ++Q E E +I + I + S C + + CH F C KPR LC+++CE + C Y ++L++LK +P CE L + C R A + K + C+N +G +Y GT S T G C W + + ++ ++YCRNP + +APWCFT R E+C + QC P L ++I IG + I +C +K+ +R KP + + E S++ K K + + PLS +RF E++GE FG +YK L P ++ +V +KTL SS + G+F+QEA +++EL H NV+ L+GV ++ P C++F+F+ GDLHE LI +RS + S D G V +L + D + +A Q+A+GMEYLS R FVH+DLAARNIL+GE L KISD+GL ++ YSSDYYR +TL LPIRWMSPEAIA+G+FT +SD+WA+GV+LWEI+S GLQPFYG SN EVME+VR RQ+L CP++CP ++Y LM ECW E P RP+FK+IH+R+R W+
Sbjct: 1 MNNITTSLGQTAELHCHVSGNPPPTVRWLKNDAPVAPEARRVSYKQTQYGSRLRIRNLDTTDTGYFQCVATNSYGTVSTTGILF-------VKFVQVSPSTKSRGYNRSLMREGFCQPYRGIACARFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNHLSDRCSQFAIPSLCHFAFPTCDRSSGIDKPRDLCKDECEILENDLCKTEYIIARSNPIILKRLK------LPNCEDLAASDSPEAANCMRIGIPMAESIN-----KNHKCFNSSGADYRGTTSVTKSGRQCQPWNSQYPHSHNFLALRYPELNGGHSYCRNP----GNKHEAPWCFTLDDSVRMELCGIPQC--GEKPYIKVKVKILYILVPSVAIPLAIGLLFFFICVCRNNQKA-------------SRPPAQRQPKPVRG--QNVEMSMLPAYKPKSKAKELPLSAVRFMEELGECAFGKIYKGHLY-----LPGMEHAQLVAIKTLKDFSSAQQWGDFQQEASVLTELHHPNVVCLLGVVTQEQPVCMLFEFLALGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHLATQVAAGMEYLSGRFFVHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYRVQPNTL-LPIRWMSPEAIAYGKFTTDSDIWAFGVVLWEIFSFGLQPFYGFSNQEVMEMVRKRQLLPCPEDCPPRMYALMTECWQEGPARRPRFKDIHARLRAWE 688
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: ror2 (receptor tyrosine kinase like orphan receptor 2 [Source:NCBI gene;Acc:103027416]) HSP 1 Score: 436.417 bits (1121), Expect = 2.954e-137 Identity = 263/733 (35.88%), Postives = 387/733 (52.80%), Query Frame = 3
Query: 375 TNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQK---PRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEY-DCYNGTGREYVGTVSQTIHGTPCVTWK-NVPG--------FEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+N+T G+ TL C +SG PRPTI W K P+V +I IR++ +GS L+I+DLD +D G+Y C A N G TA + +I + + KG+CQ ++ +C +++ +YV ++Q E E RI + I + S Q +C + + CH F +C E + R+LC+++CE + C Y + + +P C L + C R VP++ L+ Y +CYNG+G Y GTVS T G C +W P + ++ +N+CRNP Q ++PWCFT R +VC VR C P + K L I+I VI + + +C K K + N LT + P N K ++ L ++N LS +RF E++GE FG VYK L G+ + +V +KT+ L+ EF+ EA + S L+H N++ L+GV ++ P +IF + GDLHE L+ + S V + D L D + I Q+A+GMEYLSS VH+DLAARNIL+ + L KI D+GL +D YS+DYY+ GS+ PIRWMSPEAI +G+F+ +SD+W+YGV+LWEI+S GLQP+ G+SN +V+E+VR+RQ+LSCPD+CP+ +Y LMLECWNE P RP+FK+IH+R+R W+
Sbjct: 77 SNMTIMQGQTATLHCKVSGNPRPTIRWLKNDAPVVQEQGRISIRKTEFGSKLRIQDLDTTDTGYYQCVASN--GLKVITATGVLYVRLGNITHL--------------TYEKGFCQPYRGIACARFIGNRSIYVESLQMQGESENRITAAFTMIGT--STQLSDQCSQFAIPSFCHYVFPLCEEGSRGPRQRQLCRDECEALENDLCRTEYTIARSNPLILMQLELPNCHLLPHPGSPDAASCMRI----GVPIER---LETYHNCYNGSGTNYRGTVSVTKSGYQCQSWSAQYPHSHHLTPLEYPELRGGHNFCRNP----GGQMESPWCFTLDPRVRVDVCEVRAC----KPPENVKKEILYILIPSIAIPLVIACLFFLVCMCR--NKQKESVDSPPRRN-LTASPSQDMEMPLLNQ-HKHQAKLREVN----------LSAVRFMEELGEDRFGKVYKGHLYGTAPGE----QTQVVAIKTVKDKDEGSLREEFRHEAMLRSRLQHPNIVCLLGVVTKEQPMSMIFSYSGHGDLHEFLVMRSPH-----SDVGSSDDDKTVKSALEQADFLHIVTQVAAGMEYLSSHHVVHKDLAARNILVCDKLNVKILDLGLFRDVYSADYYKLMGSS-PFPIRWMSPEAIMYGKFSTDSDIWSYGVVLWEIFSYGLQPYCGYSNQDVIEMVRNRQVLSCPDDCPSWIYTLMLECWNEFPARRPRFKDIHARLRTWE 752
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: ror2 (receptor tyrosine kinase like orphan receptor 2 [Source:NCBI gene;Acc:103027416]) HSP 1 Score: 436.417 bits (1121), Expect = 3.178e-137 Identity = 267/756 (35.32%), Postives = 395/756 (52.25%), Query Frame = 3
Query: 309 IKQTDSKQPPQFEG-YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQK---PRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEY-DCYNGTGREYVGTVSQTIHGTPCVTWK-NVPG--------FEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+ + S P EG L+ + +N+T G+ TL C +SG PRPTI W K P+V +I IR++ +GS L+I+DLD +D G+Y C A N T + V +S + + KG+CQ ++ +C +++ +YV ++Q E E RI + I + S Q +C + + CH F +C E + R+LC+++CE + C Y + + +P C L + C R VP++ L+ Y +CYNG+G Y GTVS T G C +W P + ++ +N+CRNP Q ++PWCFT R +VC VR C P + K L I+I VI + + +C K K + N LT + P N K ++ L ++N LS +RF E++GE FG VYK L G+ + +V +KT+ L+ EF+ EA + S L+H N++ L+GV ++ P +IF + GDLHE L+ + S V + D L D + I Q+A+GMEYLSS VH+DLAARNIL+ + L KI D+GL +D YS+DYY+ GS+ PIRWMSPEAI +G+F+ +SD+W+YGV+LWEI+S GLQP+ G+SN +V+E+VR+RQ+LSCPD+CP+ +Y LMLECWNE P RP+FK+IH+R+R W+
Sbjct: 46 LAEAQSGGLPASEGNLLEFVEPPSNMTIMQGQTATLHCKVSGNPRPTIRWLKNDAPVVQEQGRISIRKTEFGSKLRIQDLDTTDTGYYQCVASNGLKVITATGVLYVRLGQSPTHG-----------PGDATYEKGFCQPYRGIACARFIGNRSIYVESLQMQGESENRITAAFTMIGT--STQLSDQCSQFAIPSFCHYVFPLCEEGSRGPRQRQLCRDECEALENDLCRTEYTIARSNPLILMQLELPNCHLLPHPGSPDAASCMRI----GVPIER---LETYHNCYNGSGTNYRGTVSVTKSGYQCQSWSAQYPHSHHLTPLEYPELRGGHNFCRNP----GGQMESPWCFTLDPRVRVDVCEVRAC----KPPENVKKEILYILIPSIAIPLVIACLFFLVCMCR--NKQKESVDSPPRRN-LTASPSQDMEMPLLNQ-HKHQAKLREVN----------LSAVRFMEELGEDRFGKVYKGHLYGTAPGE----QTQVVAIKTVKDKDEGSLREEFRHEAMLRSRLQHPNIVCLLGVVTKEQPMSMIFSYSGHGDLHEFLVMRSPH-----SDVGSSDDDKTVKSALEQADFLHIVTQVAAGMEYLSSHHVVHKDLAARNILVCDKLNVKILDLGLFRDVYSADYYKLMGSS-PFPIRWMSPEAIMYGKFSTDSDIWSYGVVLWEIFSYGLQPYCGYSNQDVIEMVRNRQVLSCPDDCPSWIYTLMLECWNEFPARRPRFKDIHARLRTWE 749
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Match: MUSK (muscle associated receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7525]) HSP 1 Score: 293.508 bits (750), Expect = 1.822e-86 Identity = 201/635 (31.65%), Postives = 308/635 (48.50%), Query Frame = 3
Query: 705 SKGYCQTFQSSSC-GKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSED---QKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYL-----VSVPKCEKLHNNQGCFRFNELPAVP-VKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEP------TQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSD------NKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSN----GLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSIS--TVPADSMDAYGDVT-LSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIH 2495
S GYC T++ C G +V+ E + L+A S A C L CH+ F CS P+ LC+E C V + C ++ ++ + + +++ C KL + Q + AV V K CYN GR Y G ++ T G PC W V ++ NYCRNP E T W + V E ++ + P S+ + N + I+ + F+ + I +C +K+ L + L P L L K+ + +YP + I + IGEG FG V++A G + P T +V VK L +S +Q +F++EA +M+E H N++ L+GV P CL+F++M GDL+E L + + RS+S ++ S + D T LS +++ ++ Q+A+GM YLS R FVHRDLA RN L+GE+L+ KI+D GL ++ Y++DYY+ + + +PIRWM PE+I + R+T ESDVWAYGV+LWEI+S+G+QP+YG ++ EV+ VR +L+CP+NCP ++Y+LM CW+ P RP F +IH
Sbjct: 49 SAGYCSTYRGEVCDGALRQNALVFFNFSLPDPENAQE---LLARASWSELDWASPLCRPAARSLLCHNAFQDCSPSGLGPSPKPLCREHCVAVKELYCYKEWRASEERSHRGVMSPGLSIALTDCRKLPSLQA--DPDSCTAVDYVGMKKDQITTTCYNNRGRFYQGALNVTASGIPCQRWDQQDPHPHRLPVDVIPELSNAENYCRNPGGESDRPWCYTSSPRVRWEYCLVPKCGEAVTIVRAASAPKPPPSNPIAAVSTAYYMNVIIFIIAGFAGVAFLTILILMCHKRRKTWKRRRSRVMKTPTLTALPSELLLDRLHP-----NPMYQRLPLLLNSKLLTLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPHEPFT----MVAVKMLKEEASADMQNDFQREAALMAEFDHPNIVRLLGVCAVGKPMCLMFEYMAHGDLNEFLRRRSPAQQRSLSQGSLTDQSFASESDPTPLSCLEKLSMSKQVAAGMAYLSERKFVHRDLATRNCLVGEDLVVKIADFGLSRNIYAADYYKASEND-AIPIRWMPPESIFYNRYTSESDVWAYGVVLWEIFSHGMQPYYGMAHEEVIYYVRDGHVLACPENCPLELYNLMRLCWSRHPNDRPSFASIH 668
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001705.1 (pep scaffold:Pmarinus_7.0:GL487204:7598:9057:-1 gene:ENSPMAG00000001543.1 transcript:ENSPMAT00000001705.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 235.343 bits (599), Expect = 3.913e-71 Identity = 112/247 (45.34%), Postives = 162/247 (65.59%), Query Frame = 3
Query: 1788 SVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGD--VTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNI-HSRIRVWQQ 2519
S +Q F +EA +M+E H N++ L+GV P+CL+F+FM GDL+E L ++ + S+ PA + + G V+L D++F+A Q+A+GM YL+ R FVHRDLA RN L+G L+ KISD GL + Y++DYY+ + +PIRWM PE+I + R+T ESDVWA+GV+LWEI+S+GLQP++G S+ EV+ VR +L+CPD CP +Y+LM CW P RP F ++ H R+ Q
Sbjct: 1 SPDMQANFHREAALMAEFTHPNIVKLLGVCAVGKPFCLLFEFMPHGDLNEYLRRCSSEAGLAASSPPARAPTSSGSEPVSLCCADKLFVATQVAAGMAYLAERKFVHRDLATRNCLVGNRLVVKISDFGLSQSIYAADYYKANEND-AIPIRWMPPESIFYNRYTSESDVWAFGVVLWEIFSHGLQPYFGMSHEEVIYFVRDGNVLACPDGCPLDLYNLMRLCWAHAPADRPSFASVQHVLARMHAQ 246
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: NTRK2 (neurotrophic receptor tyrosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:8032]) HSP 1 Score: 214.157 bits (544), Expect = 5.159e-62 Identity = 111/279 (39.78%), Postives = 170/279 (60.93%), Query Frame = 3
Query: 1668 QIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRI 2504
++GEG FG VY AE ++ + +V KTL S + +F +EA++++ L+H +++ GV + P ++F++M+ GDL N + +R V LS + + +QIA+GM YL+S+ FVHRDLA RN L+G L+ KI D G+ +D YS+DYYR G T MLPIRWM PE+I + +FT +SDVW+ GV+LWEI++ G QP+Y SN EV++ + ++L P +CP +VY+LML CW+ P++R K+I +R+
Sbjct: 81 ELGEGAFGKVYLAEC----SSLDVGQEPMLVAAKTLKDLSD-GARKDFYREAELLTNLQHEHIVRFYGVCVEGEPLIMVFEYMKNGDL------NKFLRLRGPDAVFMGDAPQAEPRLLSQAQMLNMGSQIAAGMAYLASQHFVHRDLATRNCLVGAGLVVKIGDFGMSRDVYSTDYYRVGGHT-MLPIRWMPPESIMYRKFTADSDVWSLGVVLWEIFTYGKQPWYQLSNTEVIDCICQGRVLERPRSCPMEVYELMLGCWHREPQHRLGIKDILARL 347
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009485.1 (pep scaffold:Pmarinus_7.0:GL477866:1219:4704:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009485.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 192.971 bits (489), Expect = 3.067e-55 Identity = 102/289 (35.29%), Postives = 160/289 (55.36%), Query Frame = 3
Query: 1650 QIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLIS--------NTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNI 2492
+++ ++G+G FG VY+ G + + V +KT++ ++++ + EF EA +M +V+ L+GV + P +I + M +GDL L S T+ + T P S+ + + +A +IA GM YL+++ FVHRDLAARN ++ E+ KI D G+ +D Y +DYYR G L LP+RWMSPE++ G FT SDVW++GV+LWEI + QP+ G SN +V++ V +L P CP ++ +L+ +CW PR RP F I
Sbjct: 12 KVKMMRELGQGTFGMVYEGLARGIVKGE----DETRVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVVSQAQPILVIMELMTRGDLKSYLRSLRPDAEDFTETIVLEKKPTRPPSSL----------PEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGL-LPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFVMDGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEI 285
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009481.1 (pep scaffold:Pmarinus_7.0:GL477866:614:5163:1 gene:ENSPMAG00000008570.1 transcript:ENSPMAT00000009481.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 195.282 bits (495), Expect = 4.565e-54 Identity = 113/348 (32.47%), Postives = 180/348 (51.72%), Query Frame = 3
Query: 1449 FVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNI 2492
FV + + +C +C N + NG+ S Y D ++ V+ +K+K+ ++G+G FG VY+ G + + V +KT++ ++++ + EF EA +M +V+ L+GV + P +I + M +GDL L S + + P+ S + + +A +IA GM YL+++ FVHRDLAARN ++ E+ KI D G+ +D Y +DYYR G L LP+RWMSPE++ G FT SDVW++GV+LWEI + QP+ G SN +V++ V +L P CP ++ +L+ +CW PR RP F I
Sbjct: 10 FVFIALCVCILC----LNRNEAAVPNGVLYASVNPEYF-STADVYIADEWEVERDKVKM------------MRELGQGTFGMVYEGLARGIVKGE----DETRVAIKTVNETATMRERYEFLNEASVMKSFNCHHVVRLLGVVSQAQPILVIMELMTRGDLKSYLRSLRPDAEKKPTRPPS-----------SLPEMLQMAGEIADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGL-LPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATQAEQPYQGLSNEQVLKFVMDGGLLVLPPACPERLQELIRKCWQYNPRMRPTFLEI 324
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7]) HSP 1 Score: 192.2 bits (487), Expect = 3.008e-53 Identity = 109/322 (33.85%), Postives = 176/322 (54.66%), Query Frame = 3
Query: 1548 LGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGL---IKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRI 2504
+ + KPC + + L+ + + P + I+ Q+++G G+FG V++ + NS++V VKTL G+ K EF EAQ+M +L+H N++ L V ++ P +I + M G L + L ++++ V +A QIA+GM YL S++++HRDLAARNIL+GE +CK++D GL IK Y +Y G+ + PI+W +PEA+ F RF+V+SDVW++G+LL+E+ + G P+ N EV++ + + PDNCP Y +MLECWN+ RP F+ + R+
Sbjct: 157 MALQKPC---VVIEAPTTIGLSYNTVDKWEIPRASIQLQKRLGAGMFGEVWQG----------LWNNSTLVAVKTLKPGAMKK--EEFIGEAQIMKQLRHANLIQLYAVCSQEEPIYIITELMRHGSLLDYLRGPLGKQLKAPELVD-------------------MARQIAAGMAYLESQNYIHRDLAARNILVGEGKVCKVADFGLARIIKVRYEDEYEGKAGAKV--PIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYGRMPYPEMGNMEVLKQLDRGYRMPQPDNCPPLFYSIMLECWNKKEEERPTFETLQWRL 442
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649]) HSP 1 Score: 83.5741 bits (205), Expect = 2.120e-17 Identity = 69/263 (26.24%), Postives = 115/263 (43.73%), Query Frame = 3
Query: 1626 TSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQG--EFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCP 2408
TS Y LS + +G G FG V+ L+ SN+N +KTL + VKL+ E +M+S + H ++ + G ++ D++E G+L LL R P F AA++ +EYL S+ ++RDL NIL+ +N KI+D G K Y TL +++PE ++ + D W++GVL++E+ + G PFY + + E + + ++ P
Sbjct: 79 TSGKYSLSDFQILRTLGTGSFGRVH---LIRSNHNG------RFYALKTLKKHTIVKLKQVEHTNDERRMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLL--------RKSQRFPNPVAK-------------FYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK------YVPDVTYTLCGTPDYIAPEVVSTKPYNKSVDWWSFGVLIYEMLA-GYTPFYNSNTMKTYENILNAELKFPP 304
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631]) HSP 1 Score: 85.1149 bits (209), Expect = 4.011e-17 Identity = 67/273 (24.54%), Postives = 126/273 (46.15%), Query Frame = 3
Query: 1587 SESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVY------KAELVGSNN-NSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFI---AAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGR-FTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVM 2372
+E+ +V +NK K + +Y E IG+G FGAVY E++ P + + I+ T+ A + E + +L H+N++ +G + + L +++ G + L+ YG D+ I Q+ G+ YL S+ +HRD+ A N+L+ ++ +CKISD G+ + S D Y + T+ + WM+PE + + ++ + D+W+ G ++ E+++ G +P+ SN EV+
Sbjct: 1153 TENHMVSINKAKNSKGEYKEFAWMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILSTVEA---------LRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLI-------------------RMYGRF-----DEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRK--SKDIYSNSDMTMRGTVFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFA-GKRPW---SNLEVV 1386
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: CTK1 (Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 [Source:SGD;Acc:S000001622]) HSP 1 Score: 76.2554 bits (186), Expect = 1.096e-14 Identity = 73/269 (27.14%), Postives = 118/269 (43.87%), Query Frame = 3
Query: 1668 QIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFK-------QEAQMMSELKHVNVLSLVGVSIR-QIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFG--RFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCP--DNCPTKVYDL 2438
Q+GEG +G VYKA+ T +V +K L +LQGE + +E +++ H NV ++ + + Q +IF++ + DL LL++ +V +S++ + Q+ GMEYL +HRD+ NILI KI+D GL + S Y TL W P + G + E D+W G LL E++ N F G + E +E + +I+ P ++ PT +YD+
Sbjct: 188 QVGEGTYGKVYKAK---------NTNTEKLVALKKL------RLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVESQKTVYMIFEYAD-NDLSGLLLNK--------------------EVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLARKMNSRADYTNRVITL-----WYRPPELLLGTTNYGTEVDMWGCGCLLVELF-NKTAIFQGSNELEQIESI--FKIMGTPTINSWPT-LYDM 411
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700]) HSP 1 Score: 73.9442 bits (180), Expect = 3.263e-14 Identity = 65/265 (24.53%), Postives = 112/265 (42.26%), Query Frame = 3
Query: 1620 KITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQG--EFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCP 2408
++TS Y L + +G G FG V+ L+ S +N +K L V+L+ E M+S + H ++ + G +I D++E G+L LL R P F AA++ +EYL S+ ++RDL NIL+ +N KI+D G K Y TL +++PE ++ + D W++G+L++E+ + G PFY + + E + + ++ P
Sbjct: 76 RVTSGKYSLQDFQILRTLGTGSFGRVH---LIRSRHNG------RYYAMKVLKKEIVVRLKQVEHTNDERLMLSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLL--------RKSQRFPNPVAK-------------FYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAK------YVPDVTYTLCGTPDYIAPEVVSTKPYNKSIDWWSFGILIYEMLA-GYTPFYDSNTMKTYEKILNAELRFPP 303
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 74.7146 bits (182), Expect = 5.117e-14 Identity = 63/292 (21.58%), Postives = 132/292 (45.21%), Query Frame = 3
Query: 1551 GIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQ-IRFQEQIGEGIFGAVYKAE------------LVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIP--WCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELV 2381
G+ KP + + + S+ ++K+K + + SQ + E+ G+G G+VY AE L+ ++ + P G+ + LS +L E +M + +H N+++ + +R W ++ +FME G L +++ ++ T + +S + ++Y I + G+++L + +HRD+ + N+L+ KI+D G C R+ +T++ WM+PE + + + DVW+ G++ E+ G P+ + + L+
Sbjct: 512 GVAKP-KKPARPTMSTAEIMSKLKKVTVNADPSQCFKVIEKAGQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKEL---IVNEILVMKDSRHKNIVNFLEAYLRTDDDLW-VVMEFMEGGSLTDIIENSPTND---------NSHSPLTEPQIAY-----IVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGF---CARLTDKRSKRATMVGTPYWMAPEVVKQREYDEKIDVWSLGIMTIEMLE-GEPPYLNEDPLKALYLI 780
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO48215 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKA9]) HSP 1 Score: 315.079 bits (806), Expect = 5.211e-95 Identity = 226/741 (30.50%), Postives = 359/741 (48.45%), Query Frame = 3
Query: 372 LTNVTGKVGKKITLECDISGKPRPTISWKKAKLPL-VDINYKIKIR---QSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHM-VYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSE---DQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYL--VSVPKCEKLHNN---QG--CFRFN--ELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK-NVPGFE--------DMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQ-IRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRV 2510
+ N TG +G+KI+L+C +SG + I+W K + L D ++ I+ + GS LKI+ L SD G Y C A + S + V + GYC + C K ++ V+++ Q E+++ IS S++ C +++ L CH F C + +PR LC ++C+ + K C+ YK +++K+ L V P CE+L + QG C R A P ++K L C+NGTG Y G +S T G C W P F ++ +NYCRNP ++ PWCFT+ R + C + +C D P +P + + F + I CW C K IY Q D + L+ + +K TS + + +R +++GEG +G VY E+ + + ++ V+V +L V ++ EF ++A+ S+L+H N++++VG+ + +P C++++++E G LHE L+ N ++ AD + G ++++Y Q+A+GM YLSS + VH DLA RN ++G KI+D+ L + YS DYYR LP+RWM+PEAI RFT E+D+W++GVLLWE++S G QP +G SN +VM +R +L CP +CP VY LM ECW+ +P RP+F IH+ + V
Sbjct: 1 MDNETGIIGRKISLKCVVSGIVQANITWYKNGIALDSDKKGRVSIKSLDKEKEGSRLKIKSLRLSDAGIYKCTAWSGL------------LLAVSNNAFLVSLLGPLLNYPGPTTRPGYCVRYTGHICSKSINHKKSVFISAVNQQGSIEKKLEIAFNTISR--SKKLSDSCQPYVLPLLCHYLFPYCDDAASQPQPRPLCYDECDLLRKDVCSEEYK----EVQKESLSVVLFPDCERLPSRDSVQGKKCIRLGIQTRRAWPKESKGDL----CFNGTGEHYNGNISVTEKGFGCQRWNVTTPHFHLMSPATYHELRGGHNYCRNP----GGKKQRPWCFTTDPRQRYDYCDIAKC--DEPPVIHVVSILYTVIPCLL---IAVIFFSVVIFFCWRCDKQI-------------------IY---QADESAAPMPLMPV-IVKTTSKIREIKESLRLLKELGEGDYGKVYFGEITTKSEGRLM---ATSVLVVSLRESHEVDVRDEFFEKAEAWSKLQHPNIITIVGMCNKSVPTCVLYEYLEYGTLHEYLVRNAPIDDPEAEEEIADPLWCDGLISIAY--------QVAAGMNYLSSNNIVHGDLATRNCMVGPGRTVKITDVALTRLGYSHDYYRQLHRR-PLPVRWMAPEAILSYRFTPETDIWSFGVLLWELFSYGAQPHFGFSNEDVMFRLRECILLPCPVDCPASVYRLMKECWDILPPSRPRFSTIHTHLGV 675
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO43993 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RX97]) HSP 1 Score: 247.284 bits (630), Expect = 6.017e-72 Identity = 175/576 (30.38%), Postives = 284/576 (49.31%), Query Frame = 3
Query: 717 CQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQK---PRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNN-----QGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWK-NVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFI---AAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCP 2408
C+ ++ + C KYL G VYV ++++ + + VA + +L++ C ++++ C+ C++D K P R C++DCE + C KL K+ + +P C L + C R V K +Y CYNGTG +Y+G ++ T +G PC++WK N P ++ +N+CRNPR Q +APWC+ E C + +C + I ++ FV + + + ++S S +++ + + +P +D K+S D +++F E +GEG F V KA L+ N + T + +K L ++ FK E ++ L+ +NVL LVGVS + P ++F++ E D+H L + + S PA D D + D++ A Q+ASGM YL+ +F+HRDLAARN I E+ + KIS++G+ Y +DY GS+L LP+RWM PEA+ FT SDVW++GV+LWEI+S G QP+ G++N E +E +R+ Q+L CP
Sbjct: 1 CEPYKGTFCSKYLKGKNVYVK------DRQQNVENKVATLIGILNRHVTDRCKEYVIPTLCNYIIPPCAKDSKKPRPIRFCRDDCEVLQNTVC----KLEFHYAKQRFAKMLPDCSVLPGPGSPEYKTCIR--------VTMKGEDNQY-CYNGTGEDYIGRLNVTKYGMPCLSWKSNDPVYK---LSHNFCRNPR----GQHEAPWCYVD-KNTYEYCVIPKCSEASDA---------------IMAVLILAFVSIIVYLKVQHRRSTLPNRDHSSSGSISKSTQSTLQQP-SSDFKQS------------LIDDANQGKVKFLELLGEGGFAKVCKAALM--RNETEYT--DVRLAIKRLKPNVPPQVVENFKNEISVLMGLQDINVLCLVGVSAGEEPLFMVFEYFEDMDMHRYL----NLHIPS----PAQLQDDLRDDCMHDPDEVLFLDFALQVASGMAYLAENNFIHRDLAARNCFITEDNIVKISNLGIGSCRYPADYSWVHGSSL-LPVRWMPPEALNSLHFTHRSDVWSFGVVLWEIYSYGRQPYSGYNNQEAIECIRNMQMLPCP 508
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO45490 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSX1]) HSP 1 Score: 217.238 bits (552), Expect = 9.697e-65 Identity = 104/235 (44.26%), Postives = 154/235 (65.53%), Query Frame = 3
Query: 1755 IVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNE 2459
IV VKTL G S +++ F QE +M+ L H N++ L+ VS + P+ +IF+FM +GDL N M R ++ + +L+ D + I+ Q++SGME+L S FVHRDLA RN L+G+ L+ KI+D G+ +D Y+SDYY+ G +M PIRWM PEA+ +GRFTVESDV+++GVLLWE+++ LQP+YG++N EV ++ L P++CP +YD+M CWN+
Sbjct: 3 IVAVKTLKQGCSNEMKTSFLQEVTLMAVLHHPNIVELLAVSTEEEPYGMIFEFMSQGDL------NQYMRKRGPYSLEEEK-------SLTQEDLLSISLQVSSGMEHLQSMRFVHRDLATRNCLVGDGLVVKIADFGMSRDVYASDYYKVEGQAVM-PIRWMPPEALLYGRFTVESDVYSFGVLLWEVYAFALQPYYGYTNEEVCGFIKKGVHLGKPEDCPDHIYDVMKSCWNK 223
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO39761 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S933]) HSP 1 Score: 214.542 bits (545), Expect = 1.135e-63 Identity = 106/230 (46.09%), Postives = 149/230 (64.78%), Query Frame = 3
Query: 1818 EAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIR 2507
+ +MS L H NV+ L+ VS + P+ +IF+FM +GDL+ L S E S P D+ D G IA Q+A+GMEY++S FVHRDLA RN L+G +++ KI+D G+ +D Y SDYY+ + T MLPIRW++PEA +G+FTV+SDV++YGVLLWEI++ GLQP+YG++N EV E ++ L PD+CP VY +M +CW+ P R F I R+R
Sbjct: 11 QVALMSILDHPNVVKLLAVSTEEEPYGMIFEFMGEGDLNHYLRSAKPAE-SSAYKGPDDAKDLVG-----------IAEQVAAGMEYVASLRFVHRDLATRNCLVGTDMVVKIADFGMSRDVYGSDYYKMSRET-MLPIRWLAPEAFLYGKFTVKSDVYSYGVLLWEIFTFGLQPYYGYTNKEVTEFIKKGIHLGRPDDCPQFVYLIMKDCWSREPEERVDFGLIQKRLR 227
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Match: EDO47652 (Tyrosine-protein kinase receptor [Source:UniProtKB/TrEMBL;Acc:A7RLS3]) HSP 1 Score: 207.223 bits (526), Expect = 4.761e-60 Identity = 112/290 (38.62%), Postives = 166/290 (57.24%), Query Frame = 3
Query: 1635 DYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRI 2504
+ P +I+ ++G G FG VY+ E N P V VKT+S +S++ + EF QEA +M + +V+ L+GV P ++ + M+ GDL L S+ EV S P ++ + +A +IA GM YL++R FVHRDLAARN ++ NL KI D G+ +D Y +DYYR G L LP+RWM+PE++ G FT SDVW++GV++WE+ + QP+ G SN EV++ V ++ PD+CP +++DLM CW P+ RP F +I S I
Sbjct: 12 EVPREKIKLIRELGNGSFGMVYEGEATDIVPNKP----KCKVAVKTVSENASIRDRIEFLQEASIMKAFQCNHVVRLLGVVSDGQPTLVVMELMDNGDLKNFLRSHRP-EVTMESDEPPPTL----------QQMLQMAGEIADGMAYLAARKFVHRDLAARNCMVNANLTVKIGDFGMTRDIYETDYYRKGGKGL-LPVRWMAPESLKDGVFTSPSDVWSFGVVMWEMATLASQPYPGKSNEEVLKYVVDGGVMPKPDDCPDRLFDLMTLCWQFSPKARPTFLSIISLI 285
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: ror1 (receptor tyrosine kinase like orphan receptor 1 [Source:NCBI gene;Acc:101166863]) HSP 1 Score: 441.81 bits (1135), Expect = 4.557e-139 Identity = 270/777 (34.75%), Postives = 408/777 (52.51%), Query Frame = 3
Query: 246 LIIIVYMVFLNQPISGFTAKDIKQTDSKQPPQFEGYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMC---SEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
LI+ L Q S A + +T S +++++ + N+T +G+ L C +SG P+P + W K P+V ++ IR +GS L+I +LD +D G++ C A N+ G +TT + V D P + + G+CQ ++ +C +++ ++V ++Q E E +I + I + S Q C + + CH F C S KPR LC+++CE + C Y + + +P CE+L + C R +P+ +P K + CYN +G +Y GTVS T G C W + + ++ ++YCRNP + +APWCFT G R E+C + C DH+ S N L ++I I + I +C + S + L R L I S L K K + + PLS +RF E++GE FG +YK L P + +V +KTL S+ K +F+QE+ +++EL+H NV+ L+GV ++ P C++F+F+ +GDLHE LI +RS + S D G V +L + D + IA Q+++GMEYL+S ++H+DLAARNIL+GE L KISD+GL ++ YSSDYY TL LPIRWM PEAIA+G+FT +SD+W++GV+LWEI+S GLQP+YG SN EVME+VR RQ+L CP++CP + Y LM ECW E P RP+FK+IH+R+R W+
Sbjct: 29 LILSATGAELPQEPSMLAATSLNKTGSP-------FIRIDAPMNNITTSLGQTAELLCRVSGNPQPEVRWLKNDAPVVQEPRRVSIRSMPYGSRLRIRNLDTTDTGYFQCMASNSKGSVSTTGVLFV-----KFDPHPTPLPGRPMDDFD---EDGFCQPYRGIACARFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNQLSDRCSQFAIPSLCHFAFPTCDRSSGSDKPRDLCKDECEILENDLCKTEYIIARSNPHILKRLKLPNCEELAASDSPEAANCLRI----GIPMP-EPINKNHKCYNSSGVDYRGTVSVTKSGRQCQPWNSQYPHSHTYLAVRYPELNGGHSYCRNP----GNKHEAPWCFTLDEGVRMELCDISIC--DHNEKASGNMEILYILVPSVAIPLAIALLFFFICVCRNNQMS--ARPPAPRQPKLVRGQNLEI------------SVLNTAYKSKGKAKELPLSAVRFMEELGECNFGKIYKGHLY-----LPGMDQAQLVAIKTLKDVSNTKQWADFQQESAVLAELQHPNVVCLLGVVTQEHPVCMLFEFLPQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQVSAGMEYLASHFYIHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYCIQPKTL-LPIRWMPPEAIAYGKFTTDSDIWSFGVVLWEIFSYGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRFYGLMTECWQEGPARRPRFKDIHTRLRAWE 751
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: ror1 (receptor tyrosine kinase like orphan receptor 1 [Source:NCBI gene;Acc:101166863]) HSP 1 Score: 441.81 bits (1135), Expect = 4.557e-139 Identity = 270/777 (34.75%), Postives = 408/777 (52.51%), Query Frame = 3
Query: 246 LIIIVYMVFLNQPISGFTAKDIKQTDSKQPPQFEGYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMC---SEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
LI+ L Q S A + +T S +++++ + N+T +G+ L C +SG P+P + W K P+V ++ IR +GS L+I +LD +D G++ C A N+ G +TT + V D P + + G+CQ ++ +C +++ ++V ++Q E E +I + I + S Q C + + CH F C S KPR LC+++CE + C Y + + +P CE+L + C R +P+ +P K + CYN +G +Y GTVS T G C W + + ++ ++YCRNP + +APWCFT G R E+C + C DH+ S N L ++I I + I +C + S + L R L I S L K K + + PLS +RF E++GE FG +YK L P + +V +KTL S+ K +F+QE+ +++EL+H NV+ L+GV ++ P C++F+F+ +GDLHE LI +RS + S D G V +L + D + IA Q+++GMEYL+S ++H+DLAARNIL+GE L KISD+GL ++ YSSDYY TL LPIRWM PEAIA+G+FT +SD+W++GV+LWEI+S GLQP+YG SN EVME+VR RQ+L CP++CP + Y LM ECW E P RP+FK+IH+R+R W+
Sbjct: 29 LILSATGAELPQEPSMLAATSLNKTGSP-------FIRIDAPMNNITTSLGQTAELLCRVSGNPQPEVRWLKNDAPVVQEPRRVSIRSMPYGSRLRIRNLDTTDTGYFQCMASNSKGSVSTTGVLFV-----KFDPHPTPLPGRPMDDFD---EDGFCQPYRGIACARFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNQLSDRCSQFAIPSLCHFAFPTCDRSSGSDKPRDLCKDECEILENDLCKTEYIIARSNPHILKRLKLPNCEELAASDSPEAANCLRI----GIPMP-EPINKNHKCYNSSGVDYRGTVSVTKSGRQCQPWNSQYPHSHTYLAVRYPELNGGHSYCRNP----GNKHEAPWCFTLDEGVRMELCDISIC--DHNEKASGNMEILYILVPSVAIPLAIALLFFFICVCRNNQMS--ARPPAPRQPKLVRGQNLEI------------SVLNTAYKSKGKAKELPLSAVRFMEELGECNFGKIYKGHLY-----LPGMDQAQLVAIKTLKDVSNTKQWADFQQESAVLAELQHPNVVCLLGVVTQEHPVCMLFEFLPQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQVSAGMEYLASHFYIHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYCIQPKTL-LPIRWMPPEAIAYGKFTTDSDIWSFGVVLWEIFSYGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRFYGLMTECWQEGPARRPRFKDIHTRLRAWE 751
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: ror1 (receptor tyrosine kinase like orphan receptor 1 [Source:NCBI gene;Acc:101166863]) HSP 1 Score: 431.024 bits (1107), Expect = 1.254e-135 Identity = 262/735 (35.65%), Postives = 394/735 (53.61%), Query Frame = 3
Query: 372 LTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMC---SEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNNQG-----CFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKN---------VPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDV--TLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQ 2516
+ N+T +G+ L C +SG P+P + W K P+V ++ IR +GS L+I +LD +D G++ C A N+ G +TT + V K P + + ++ + G+CQ ++ +C +++ ++V ++Q E E +I + I + S Q C + + CH F C S KPR LC+++CE + C Y + + +P CE+L + C R +P+ +P K + CYN +G +Y GTVS T G C W + + ++ ++YCRN P + +APWCFT G R E+C + C DH+ S N L ++I I + I +C + S + L R L I S L K K + + PLS +RF E++GE FG +YK L P + +V +KTL S+ K +F+Q A +++EL+H NV+ L+GV ++ P C++F+F+ +GDLHE LI +RS + S D G V +L + D + IA Q+++GMEYL+S ++H+DLAARNIL+GE L KISD+GL ++ YSSDYY TL LPIRWM PEAIA+G+FT +SD+W++GV+LWEI+S GLQP+YG SN EVME+VR RQ+L CP++CP + Y LM ECW E P RP+FK+IH+R+R W+
Sbjct: 1 MNNITTSLGQTAELLCRVSGNPQPEVRWLKNDAPVVQEPRRVSIRSMPYGSRLRIRNLDTTDTGYFQCMASNSKGSVSTTGVLFVKFG----KKTPPPPTKSGYWDDFD--EDGFCQPYRGIACARFIGNRSIFVDSLQMQGEIETQITAAFTMIGT--SNQLSDRCSQFAIPSLCHFAFPTCDRSSGSDKPRDLCKDECEILENDLCKTEYIIARSNPHILKRLKLPNCEELAASDSPEAANCLRI----GIPMP-EPINKNHKCYNSSGVDYRGTVSVTKSGRQCQPWNSQYPHSHTYLAVRYPELNGGHSYCRN----PGNKHEAPWCFTLDEGVRMELCDISIC--DHNEKASGNMEILYILVPSVAIPLAIALLFFFICVCRNNQMS--ARPPAPRQPKLVRGQNLEI------------SVLNTAYKSKGKAKELPLSAVRFMEELGECNFGKIYKGHLY-----LPGMDQAQLVAIKTLKDVSNTKQWADFQQSA-VLAELQHPNVVCLLGVVTQEHPVCMLFEFLPQGDLHEFLI------MRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQVSAGMEYLASHFYIHKDLAARNILVGEQLHVKISDLGLSREIYSSDYYCIQPKTL-LPIRWMPPEAIAYGKFTTDSDIWSFGVVLWEIFSYGLQPYYGFSNQEVMEMVRKRQLLPCPEDCPPRFYGLMTECWQEGPARRPRFKDIHTRLRAWE 689
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: ror2 (receptor tyrosine kinase like orphan receptor 2 [Source:NCBI gene;Acc:101175048]) HSP 1 Score: 428.328 bits (1100), Expect = 3.259e-134 Identity = 262/743 (35.26%), Postives = 394/743 (53.03%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINY-KIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSED---QKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTW--------KNVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLV----QLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
+L+ + + N+T G+ TL C ++G PRP I W K P VD++ +I IR++ GS L+I++LD +D G+Y C A N+F + T + V + IP ++ +KG+CQ ++ +C ++L +YV + Q E+E RI + I + S Q +C K + C+ F +C E Q+ R+LC+++CE + C+ Y + + +P+C L C R P + P ++ CYNG+G +Y GTVS T G C W ++ + ++ A +N+CRNP Q +APWCFT R ++C + C SP K L +SI V+ + + C K ++G+ HS+ N C E L Q N K+ + +S +RF E++GE FG VYK L G+ +P N IV +KTL+ + + L EF+ EA L+H N++SL+GV ++ P +IF + GDLHE L+ ++ S V + D T+ D + I QIA+GMEYLSS VH+DLAARNIL+ + L KI D+GL++D YS+DYY T PIRWMSPEAI +G+F+ +SD+W+YGVLLWE +S GLQP+ G+SN +V+E+VRS Q+L CP++CPT +Y LMLECW+E+P RP+FK+IH+R+ W
Sbjct: 50 FLEFLEPVNNITHFQGQTATLHCKVAGNPRPLIQWLKNDAP-VDLDLGRITIRKTEAGSKLRIQELDTTDTGYYQCVASNSFKVISATGVLYV-----KLGLIPTHGPDKP------KNNKGFCQPYRGIACARFLGNQSIYVESLQTQGERENRITAAFTMIGT--STQLSDQCSKFAIPSFCYYVFPLCDESWRSQRQRQLCRDECEALENDLCHVEYTIARSNPMILMQLELPRCHLLPRPGTPEAASCIRIGVPPERLGSSSP--SDHSCYNGSGADYRGTVSTTRSGRSCQPWSLQLPHSHRSTQEYPELWASHNFCRNP----GGQMEAPWCFTLDPEMRMDLCDIPPCKPPESP----GKEILLILIPAVSIPLVVACLFFLVCTCR-SKHKASSSSGAPHSH--------------LNTCANQEVQLSLLSPQKNPTKLREIN--MSTVRFMEELGEDRFGKVYKGHLYGT---APGEQNQ-IVAIKTLNDKADLTLCEEFRHEASTRCLLQHQNIVSLIGVVTKEQPMSMIFTYSSLGDLHEYLVMHSPN-----SDVGSSDDDRTTKSTVEQADFLSIITQIAAGMEYLSSHQVVHKDLAARNILVFDKLNIKILDLGLLRDVYSADYYNLM-RTSPFPIRWMSPEAIVYGKFSTDSDIWSYGVLLWETYSYGLQPYCGYSNLDVIEMVRSHQLLPCPEDCPTWIYALMLECWSELPVRRPRFKDIHARLLSW 741
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Match: ror2 (receptor tyrosine kinase like orphan receptor 2 [Source:NCBI gene;Acc:101175048]) HSP 1 Score: 425.631 bits (1093), Expect = 1.891e-133 Identity = 259/742 (34.91%), Postives = 396/742 (53.37%), Query Frame = 3
Query: 351 YLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINY-KIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSR---SKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSED---QKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLH-----NNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTW--------KNVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNR-EVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVW 2513
+L+ + + N+T G+ TL C ++G PRP I W K P VD++ +I IR++ GS L+I++LD +D G+Y C A N+F + + + + + + E + R +KG+CQ ++ +C ++L +YV + Q E+E RI + I + S Q +C K + C+ F +C E Q+ R+LC+++CE + C+ Y + + +P+C L C R VP + ++ CYNG+G +Y GTVS T G C W ++ + ++ A +N+CRNP Q +APWCFT R ++C + C SP K L +SI V+ + + C K ++G+ HS+ T C N ++ + SL+ K + +S +RF E++GE FG VYK L G+ +P N IV +KTL+ + + L EF+ EA L+H N++SL+GV ++ P +IF + GDLHE L+ ++ S V + D T+ D + I QIA+GMEYLSS VH+DLAARNIL+ + L KI D+GL++D YS+DYY T PIRWMSPEAI +G+F+ +SD+W+YGVLLWE +S GLQP+ G+SN +V+E+VRS Q+L CP++CPT +Y LMLECW+E+P RP+FK+IH+R+ W
Sbjct: 25 FLEFLEPVNNITHFQGQTATLHCKVAGNPRPLIQWLKNDAP-VDLDLGRITIRKTEAGSKLRIQELDTTDTGYYQCVASNSF----------KVISATGVLYVKLGKDGGEIEHGADDRCRNNKGFCQPYRGIACARFLGNQSIYVESLQTQGERENRITAAFTMIGT--STQLSDQCSKFAIPSFCYYVFPLCDESWRSQRQRQLCRDECEALENDLCHVEYTIARSNPMILMQLELPRCHLLPRPGTPEAASCIRI----GVPPERLASPSDHSCYNGSGADYRGTVSTTRSGRSCQPWSLQLPHSHRSTQEYPELWASHNFCRNP----GGQMEAPWCFTLDPEMRMDLCDIPPCKPPESP----GKEILLILIPAVSIPLVVACLFFLVCTCR-SKHKASSSSGAPHSHLNT----------CAN--QEVQLSLLSPQKNPTKLREINMSTVRFMEELGEDRFGKVYKGHLYGT---APGEQNQ-IVAIKTLNDKADLTLCEEFRHEASTRCLLQHQNIVSLIGVVTKEQPMSMIFTYSSLGDLHEYLVMHSPN-----SDVGSSDDDRTTKSTVEQADFLSIITQIAAGMEYLSSHQVVHKDLAARNILVFDKLNIKILDLGLLRDVYSADYYNLM-RTSPFPIRWMSPEAIVYGKFSTDSDIWSYGVLLWETYSYGLQPYCGYSNLDVIEMVRSHQLLPCPEDCPTWIYALMLECWSELPVRRPRFKDIHARLLSW 718
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000041792.1 (SMESG000041792.1) HSP 1 Score: 1715.28 bits (4441), Expect = 0.000e+0 Identity = 866/868 (99.77%), Postives = 868/868 (100.00%), Query Frame = 3
Query: 222 MLKCSKKLLIIIVYMVFLNQPISGFTAKDIKQTDSKQPPQFEGYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGXXXXXXXXXXXXXXSSIDKIPVXXXXXXXXXXXXSRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKNVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDVEINPNCIGAGSARXXXXXXXXXXXXXXXEMCSDHSHLLTGYSPATCQTNQDPSTNGIVNNITFNQQFDPPSLLSQSGPMHFSRLPNTNTIYLPELSHIV 2825
MLKCSKKLLIIIVY++FLNQPISGFTAKDIKQTDSKQPPQFEGYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGYTNTTAYVTVTKTKSSIDKIPVENEEEEFIENEESRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKNVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDVEINPNCIGAGSARSVSHSGGSKHTTSSTEMCSDHSHLLTGYSPATCQTNQDPSTNGIVNNITFNQQFDPPSLLSQSGPMHFSRLPNTNTIYLPELSHIV
Sbjct: 1 MLKCSKKLLIIIVYLIFLNQPISGFTAKDIKQTDSKQPPQFEGYLKLNKILTNVTGKVGKKITLECDISGKPRPTISWKKAKLPLVDINYKIKIRQSLWGSTLKIEDLDFSDEGFYTCQAENTFGYTNTTAYVTVTKTKSSIDKIPVENEEEEFIENEESRSKGYCQTFQSSSCGKYLSGHMVYVTHGRVQAEKERRIASLVAEISSVLSQQADQECLKHIMRLTCHDNFLMCSEDQKPRRLCQEDCEDVTKKRCNYTYKLMLQKLKKDYLVSVPKCEKLHNNQGCFRFNELPAVPVKTKPPLKEYDCYNGTGREYVGTVSQTIHGTPCVTWKNVPGFEDMVADNNYCRNPRLEPTQQQDAPWCFTSVTGNREVCSVRQCIKDHSPSFSDNKSFRNFLPVYISIGCVIGFVIMTISICWICKKSKFGTNGSCHSNGLTRKSYLGIYKPCQNDCKKSESSLVQLNKIKITSTDYPLSQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDVEINPNCIGAGSARSVSHSGGSKHTTSSTEMCSDHSHLLTGYSPATCQTNQDPSTNGIVNNITFNQQFDPPSLLSQSGPMHFSRLPNTNTIYLPELSHIV 868
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000042606.1 (SMESG000042606.1) HSP 1 Score: 190.66 bits (483), Expect = 1.696e-49 Identity = 103/301 (34.22%), Postives = 167/301 (55.48%), Query Frame = 3
Query: 1647 SQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIR-----VWQQEDVEI 2534
++I + Q+G G +G VY+A S V VKT+ + + + +F +EA++M L+H N++ L+GV ++ P +I +FME G+L E L RS +P + +++A QIA+GMEYL +F+HRDLAARN L+G++ + K++D GL + C D T PI+W +PE +A+ +F+ +SDVWA+GVLLWE+ + G+ P+ G +V + I++ P CP +YD+M +CW P RP FK++H+ + + +Q D+EI
Sbjct: 253 TEIMMKNQLGSGQYGIVYEAFW---------KKYSITVAVKTVK--TDITVADDFLEEARLMKSLQHPNLVRLLGVCTQEPPNYIIAEFMENGNLLEYL------RTRSKEDLPPPVL-------------LYMAIQIAAGMEYLEQHNFIHRDLAARNCLVGQDNIVKVADFGLAR-CMERDDTYTAHVGAKFPIKWTAPEGLAYNQFSTKSDVWAFGVLLWELATYGMTPYPGIELQDVYVYLEKGNIMNRPAGCPDNIYDIMKQCWQWFPESRPSFKDLHNELEKMLSNINEQIDLEI 522
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000056885.1 (SMESG000056885.1) HSP 1 Score: 183.341 bits (464), Expect = 2.922e-47 Identity = 97/286 (33.92%), Postives = 158/286 (55.24%), Query Frame = 3
Query: 1647 SQIRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRI 2504
S+I +++G G +G VY+A N ++ VKTL ++K++ +F +EA +M L+H N++ L+GV I++ P+ LI +++ KG+L L +EV + +++A QIA GM YL +F+HRDLAARN L+G+N + K+ D GL + D Y T PI+W +PE +AF +F+ +SD+WA+GV+LWE+ + GL P+ G +V ++ + P+ CP VY +ML+CW P RP F ++S++
Sbjct: 247 SEILMHQKLGGGQYGDVYEAVWKRYN---------VVIAVKTLKEDLNLKIE-DFLKEALVMKNLRHKNLVQLLGVCIKEPPFYLITEYISKGNLLHFLRKCNQLEVTP-------------------SILLYMATQIADGMTYLEENNFIHRDLAARNCLVGDNYLLKVGDFGLARYIQRDDSY-TAKIGAKFPIKWTAPEGLAFNKFSSKSDIWAFGVVLWELATYGLSPYPGIELHDVYHILEKGYRMDRPEGCPEIVYGIMLQCWQWDPLLRPSFAQLYSKL 502
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000016930.1 (SMESG000016930.1) HSP 1 Score: 176.792 bits (447), Expect = 4.037e-46 Identity = 106/299 (35.45%), Postives = 153/299 (51.17%), Query Frame = 3
Query: 1653 IRFQEQIGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGLIKDCY-SSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIRVWQQEDVEINPNC 2546
I +++G G FG VY+ I ++ V VKTL G+ K EF +EA++M L H N++ L V + P ++ + M KG L E L T + MD + +QIA+GM YL ++HRDLAARNILIGEN +CKI+D GL + SSD Y PI+W +PEA G+FTV+SDVW+YG++L+EI ++G PF +N + ++ V + P NCP ++Y +ML CW +P RP FK + + + P C
Sbjct: 360 IELLKKLGSGNFGEVYQG----------IWNKTTDVAVKTLKPGTMAK--EEFLKEARIMKRLNHSNLVRLYAVCSDE-PIYIVTELMTKGSLLEYL------REEGKHTELKELMD--------------MMSQIANGMAYLEKEGYIHRDLAARNILIGENNICKIADFGLTRVIQGSSDTYNARQGA-KFPIKWTAPEAALMGKFTVKSDVWSYGIVLYEIITHGQTPFPAMNNTQTLQQVEKGYRMPKPSNCPQELYKVMLYCWEALPENRPTFKYLSEFFDDFSSAECSYKPAC 624
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Match: SMESG000077240.1 (SMESG000077240.1) HSP 1 Score: 177.178 bits (448), Expect = 5.690e-45 Identity = 106/282 (37.59%), Postives = 153/282 (54.26%), Query Frame = 3
Query: 1671 IGEGIFGAVYKAELVGSNNNSPITGNSSIVIVKTLSAGSSVKLQGEFKQEAQMMSELKHVNVLSLVGVSIRQIPWCLIFDFMEKGDLHELLISNTTMEVRSISTVPADSMDAYGDVTLSYTDQIFIAAQIASGMEYLSSRSFVHRDLAARNILIGENLMCKISDIGL---IKDCYSSDYYRTTGSTLMLPIRWMSPEAIAFGRFTVESDVWAYGVLLWEIWSNGLQPFYGHSNAEVMELVRSRQILSCPDNCPTKVYDLMLECWNEMPRYRPQFKNIHSRIR 2507
IG+G FG VY+ L + IV VK L G+S K + +F EA M + + NVL L GV + +I +FM G L L ++ ++T+ M + +A+GM+YLSS F+HRDLAARNIL+ ENL+CK++D GL + D + D Y T LPI+W +PEAI +G+F+ SDVW++GV+ WE+ S G +P++ SN EV++ ++S L P NCP +++LML CWN RP F +I I
Sbjct: 661 IGQGEFGHVYQGVLFVPEDER------KIVAVKVLKDGASEKERNDFLVEASTMGQFMNENVLKLEGVMTGSNSYMIITEFMVNGSLLTFL----RIKKNELTTIQLLKM----------------LSNVANGMKYLSSIGFIHRDLAARNILLDENLVCKVADFGLSRELSDKDADDIY-TNKPDGKLPIKWTAPEAILYGKFSHASDVWSFGVVCWEVLSYGEKPYWQWSNHEVIDAIQSGYRLPPPVNCPPIMHNLMLHCWNLNSDKRPTFPHISYEIE 915 The following BLAST results are available for this feature:
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Tyrosine-protein kinase receptor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029811 ID=SMED30029811|Name=Tyrosine-protein kinase receptor|organism=Schmidtea mediterranea sexual|type=transcript|length=2984bpback to top protein sequence of SMED30029811-orf-1 >SMED30029811-orf-1 ID=SMED30029811-orf-1|Name=SMED30029811-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=869bp MLKCSKKLLIIIVYMVFLNQPISGFTAKDIKQTDSKQPPQFEGYLKLNKIback to top Aliases
The feature 'Tyrosine-protein kinase receptor' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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