histone lysine N methyltransferase MLL-1
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029784 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11
Homology
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Human
Match: KMT2A (lysine methyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:7132]) HSP 1 Score: 236.498 bits (602), Expect = 3.771e-61 Identity = 120/292 (41.10%), Postives = 163/292 (55.82%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 W + ++ + R + L + +G G+ H V++L+EQ+ A C NY+F+FHK + ++PHG R + A D FL SK PP+ + ++ L R R+ + V V S IHGRGLF +R DA E++IEY G VIRSI +D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A RKIY+GEELTYDY+FPIED +KLPC CG+ C+K+LN Sbjct: 3651 AWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPE------EANEPPLNPHGSARAEVHLRKS----AFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR-FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 3931 HSP 2 Score: 131.724 bits (330), Expect = 1.767e-29 Identity = 77/223 (34.53%), Postives = 121/223 (54.26%), Query Frame = 1 Query: 5221 EFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 E N +D R CALC GDD GRL+Y G + W HVNCALWS +V+E +DG+L NV +A+ +G++ C CQK GAT+ C C +SC + YHF C+ + VF + + YC + H + + + + RR+++ +S+ +G+ +NI + IG++ I+C+G +++ SD L PIGYQ R++WS + +Y Sbjct: 1822 ELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGC--------CLTSCTSNYHFMCSRAK--NCVFLDDKKVYC-QRHRDLIKGEVVPENGFEVFRRVFV---DFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSD-CEDKLFPIGYQCSRVYWSTTDARKRCVY 2029 HSP 3 Score: 90.5077 bits (223), Expect = 5.968e-17 Identity = 62/194 (31.96%), Postives = 87/194 (44.85%), Query Frame = 1 Query: 3694 QLIHCVSCAEPFHFFCIEYQFRPKSKEM--FVCRNCTKCHSC----DVYGSDLKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCP---ECGRAYQAGLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 + ++C C EPFH FC+E RP ++ + CR C CH C L+C KC+ +HP C+ YP + K W C KC C CG+ T + WS D C CA+ G+ CP +C + ++C C+R VH +C LS++ YEI PE S A+ C C Sbjct: 1406 KFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGS---------TTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPE----SVAYTCVNC 1586
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Human
Match: KMT2A (lysine methyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:7132]) HSP 1 Score: 236.113 bits (601), Expect = 5.122e-61 Identity = 120/292 (41.10%), Postives = 163/292 (55.82%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 W + ++ + R + L + +G G+ H V++L+EQ+ A C NY+F+FHK + ++PHG R + A D FL SK PP+ + ++ L R R+ + V V S IHGRGLF +R DA E++IEY G VIRSI +D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A RKIY+GEELTYDY+FPIED +KLPC CG+ C+K+LN Sbjct: 3689 AWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPE------EANEPPLNPHGSARAEVHLRKS----AFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR-FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 3969 HSP 2 Score: 132.109 bits (331), Expect = 1.472e-29 Identity = 77/223 (34.53%), Postives = 121/223 (54.26%), Query Frame = 1 Query: 5221 EFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 E N +D R CALC GDD GRL+Y G + W HVNCALWS +V+E +DG+L NV +A+ +G++ C CQK GAT+ C C +SC + YHF C+ + VF + + YC + H + + + + RR+++ +S+ +G+ +NI + IG++ I+C+G +++ SD L PIGYQ R++WS + +Y Sbjct: 1860 ELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGC--------CLTSCTSNYHFMCSRAK--NCVFLDDKKVYC-QRHRDLIKGEVVPENGFEVFRRVFV---DFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSD-CEDKLFPIGYQCSRVYWSTTDARKRCVY 2067 HSP 3 Score: 105.916 bits (263), Expect = 1.229e-21 Identity = 72/221 (32.58%), Postives = 103/221 (46.61%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSKEM--FVCRNCTKCHSC----DVYGSDLKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCP---ECGRAYQAGLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +V+C+ C S G + ++C C EPFH FC+E RP ++ + CR C CH C L+C KC+ +HP C+ YP + K W C KC C CG+ T + WS D C CA+ G+ CP +C + ++C C+R VH +C LS++ YEI PE S A+ C C Sbjct: 1418 GGLGILTSVPITP-RVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGS---------TTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPE----SVAYTCVNC 1624
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Human
Match: KMT2A (lysine methyltransferase 2A [Source:HGNC Symbol;Acc:HGNC:7132]) HSP 1 Score: 236.113 bits (601), Expect = 5.433e-61 Identity = 120/292 (41.10%), Postives = 163/292 (55.82%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 W + ++ + R + L + +G G+ H V++L+EQ+ A C NY+F+FHK + ++PHG R + A D FL SK PP+ + ++ L R R+ + V V S IHGRGLF +R DA E++IEY G VIRSI +D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A RKIY+GEELTYDY+FPIED +KLPC CG+ C+K+LN Sbjct: 3692 AWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPE------EANEPPLNPHGSARAEVHLRKS----AFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR-FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 3972 HSP 2 Score: 132.109 bits (331), Expect = 1.484e-29 Identity = 77/223 (34.53%), Postives = 121/223 (54.26%), Query Frame = 1 Query: 5221 EFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 E N +D R CALC GDD GRL+Y G + W HVNCALWS +V+E +DG+L NV +A+ +G++ C CQK GAT+ C C +SC + YHF C+ + VF + + YC + H + + + + RR+++ +S+ +G+ +NI + IG++ I+C+G +++ SD L PIGYQ R++WS + +Y Sbjct: 1863 ELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGC--------CLTSCTSNYHFMCSRAK--NCVFLDDKKVYC-QRHRDLIKGEVVPENGFEVFRRVFV---DFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSD-CEDKLFPIGYQCSRVYWSTTDARKRCVY 2070 HSP 3 Score: 102.449 bits (254), Expect = 1.353e-20 Identity = 75/224 (33.48%), Postives = 104/224 (46.43%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSKEM--FVCRNCTKCHSC----DVYGSDLKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCP---ECGRAYQAGLETIECNSCNRMVHRQCCGLS--EDE-YEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +V+C+ C S G + ++C C EPFH FC+E RP ++ + CR C CH C L+C KC+ +HP C+ YP + K W C KC C CG+ T + WS D C CA+ G+ CP +C + ++C C+R VH +C LS EDE YEI PE S A+ C C Sbjct: 1418 GGLGILTSVPITP-RVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGS---------TTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEILSNLPE----SVAYTCVNC 1627
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Human
Match: KMT2B (lysine methyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:15840]) HSP 1 Score: 213.772 bits (543), Expect = 2.211e-54 Identity = 120/314 (38.22%), Postives = 172/314 (54.78%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G ++S + W +++++ + R L G G+ H VI+L EQ+ A +C +Y+F++H+ + ++PHG R + + D FL S+ P+ + L A +FR+L+ + V V S IHGRGLF +R DA E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNC+++V+ EG+KHI+I A R+I +GEELTYDY+FPIED +KLPC CG+ C+++LN Sbjct: 2392 LRFEISSEDGFSVEAESLEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPP-----LNPHGAARAEVYLRK----CTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKK---TSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2693 HSP 2 Score: 124.79 bits (312), Expect = 2.359e-27 Identity = 91/298 (30.54%), Postives = 139/298 (46.64%), Query Frame = 1 Query: 4975 RAKLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGREEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAF----PSEFNSTICEKDIRHCALCA--GSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVD-MPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWS 5847 RA M+ L + ++ FD +L N ++ S H+ A + E + + AF P+ F+ +D R CALC G D + GRL+Y G + W HVNCA+WS +V+E DG+L NV A+ +G + C C K GAT+ C C SSC + +HF CA +F + + +C + H + + ++ D +LRR+Y+ + N G+ D I V IG++RI+ +G + + SD L PIGYQ RL+WS Sbjct: 1466 RAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVL---PNAVLPPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHL---EDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGC--------CLSSCLSNFHFMCARASY--CIFQDDKKVFC-QKHTDLLDGKEIVNPDGFDVLRRVYVDFEGI-NFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSD-CEGRLFPIGYQCSRLYWS 1744 HSP 3 Score: 117.472 bits (293), Expect = 3.762e-25 Identity = 73/221 (33.03%), Postives = 108/221 (48.87%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFR--PKSKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSDDK-SNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG V+T+V P ++C C S G +L+ C C +PFH FC+E R P+ + + CR C CH C G L+C +C+ +HP C+ PTR+ K +W C C C CGA T + +++WS D C RC + G+ CP C R Y+ + ++C C+ VH +C GLS+++YEI P+ S + C C Sbjct: 1166 GGLSVLTSVPGGP-PMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGA----------TPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPD----SVLYTCGPC 1371
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Human
Match: KMT2B (lysine methyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:15840]) HSP 1 Score: 213.772 bits (543), Expect = 2.376e-54 Identity = 120/314 (38.22%), Postives = 172/314 (54.78%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G ++S + W +++++ + R L G G+ H VI+L EQ+ A +C +Y+F++H+ + ++PHG R + + D FL S+ P+ + L A +FR+L+ + V V S IHGRGLF +R DA E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNC+++V+ EG+KHI+I A R+I +GEELTYDY+FPIED +KLPC CG+ C+++LN Sbjct: 2414 LRFEISSEDGFSVEAESLEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPP-----LNPHGAARAEVYLRK----CTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKK---TSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2715 HSP 2 Score: 124.79 bits (312), Expect = 2.424e-27 Identity = 91/298 (30.54%), Postives = 139/298 (46.64%), Query Frame = 1 Query: 4975 RAKLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGREEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAF----PSEFNSTICEKDIRHCALCA--GSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVD-MPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWS 5847 RA M+ L + ++ FD +L N ++ S H+ A + E + + AF P+ F+ +D R CALC G D + GRL+Y G + W HVNCA+WS +V+E DG+L NV A+ +G + C C K GAT+ C C SSC + +HF CA +F + + +C + H + + ++ D +LRR+Y+ + N G+ D I V IG++RI+ +G + + SD L PIGYQ RL+WS Sbjct: 1488 RAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVL---PNAVLPPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHL---EDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGC--------CLSSCLSNFHFMCARASY--CIFQDDKKVFC-QKHTDLLDGKEIVNPDGFDVLRRVYVDFEGI-NFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSD-CEGRLFPIGYQCSRLYWS 1766 HSP 3 Score: 117.472 bits (293), Expect = 4.031e-25 Identity = 74/221 (33.48%), Postives = 107/221 (48.42%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFR--PKSKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSDDK-SNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG V+T+V P V C C S G +L+ C C +PFH FC+E R P+ + + CR C CH C G L+C +C+ +HP C+ PTR+ K +W C C C CGA T + +++WS D C RC + G+ CP C R Y+ + ++C C+ VH +C GLS+++YEI P+ S + C C Sbjct: 1188 GGLSVLTSVPGGPPMV-CLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGA----------TPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPD----SVLYTCGPC 1393
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Celegans
Match: set-2 (Histone-lysine N-methyltransferase set-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18221]) HSP 1 Score: 169.859 bits (429), Expect = 1.127e-42 Identity = 76/147 (51.70%), Postives = 105/147 (71.43%), Query Frame = 1 Query: 7660 NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 N + R K ++ S IHG GL+A E+I+EY+G+ IRS++++ RE Y+R G+ Y+FR+D ++DAT +GN ARFINHSC PNCYAKV+ EGEK I+I ++ I KGEE+TYDY+FPIEDDK+ C CG+ +C+ YLN Sbjct: 593 NQLKFRKKMIKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDYKFPIEDDKIDCLCGAKTCRGYLN 739
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Celegans
Match: set-2 (Histone-lysine N-methyltransferase set-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18221]) HSP 1 Score: 170.244 bits (430), Expect = 1.031e-41 Identity = 76/147 (51.70%), Postives = 105/147 (71.43%), Query Frame = 1 Query: 7660 NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 N + R K ++ S IHG GL+A E+I+EY+G+ IRS++++ RE Y+R G+ Y+FR+D ++DAT +GN ARFINHSC PNCYAKV+ EGEK I+I ++ I KGEE+TYDY+FPIEDDK+ C CG+ +C+ YLN Sbjct: 1361 NQLKFRKKMIKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDYKFPIEDDKIDCLCGAKTCRGYLN 1507
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Celegans
Match: set-2 (Histone-lysine N-methyltransferase set-2 [Source:UniProtKB/Swiss-Prot;Acc:Q18221]) HSP 1 Score: 170.244 bits (430), Expect = 1.077e-41 Identity = 76/147 (51.70%), Postives = 105/147 (71.43%), Query Frame = 1 Query: 7660 NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 N + R K ++ S IHG GL+A E+I+EY+G+ IRS++++ RE Y+R G+ Y+FR+D ++DAT +GN ARFINHSC PNCYAKV+ EGEK I+I ++ I KGEE+TYDY+FPIEDDK+ C CG+ +C+ YLN Sbjct: 1364 NQLKFRKKMIKFARSRIHGWGLYAMESIAPDEMIVEYIGQTIRSLVAEEREKAYERRGIGSSYLFRIDLHHVIDATKRGNFARFINHSCQPNCYAKVLTIEGEKRIVIYSRTIIKKGEEITYDYKFPIEDDKIDCLCGAKTCRGYLN 1510
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Celegans
Match: set-16 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:G5EGI1]) HSP 1 Score: 130.954 bits (328), Expect = 1.293e-29 Identity = 64/137 (46.72%), Postives = 86/137 (62.77%), Query Frame = 1 Query: 7702 SNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEG---EKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 S I G GL+A+ + IIEY GE+IRS + +VRE Y YMFR+D++ ++DAT G AR+INHSC PNC +++ EK III A R I EELTYDY+F +E DK+PC CG+ +C K++N Sbjct: 2339 SRIAGLGLYAKVDISMGDFIIEYKGEIIRSEVCEVREIRYVAQNRGVYMFRIDEEWVIDATMAGGPARYINHSCDPNCSTQILDAGSGAREKKIIITANRPISANEELTYDYQFELEGTTDKIPCLCGAPNCVKWMN 2475 HSP 2 Score: 93.2041 bits (230), Expect = 3.211e-18 Identity = 68/217 (31.34%), Postives = 100/217 (46.08%), Query Frame = 1 Query: 5248 DIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLP--QGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECS---DYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 D R C C G GD GRLI WVHVNCALWS +V+E + G L NVD A+ + + C C++ GA+++C + CG + YH CA M + F + RTF C + H+ + +D LRRIY+ + + TDG + + +G +G I + + Y+ P Y+ RLFWS +M+ Sbjct: 1900 DKRICVFCGGIGDGETTRCGRLISLTEFYWVHVNCALWSAEVFENQTGGLTNVDRAVLRAAQTACDHCKRPGASVKCHKMN----CGVN----YHVLCA--MQNNGFFIKDRTFICKQ-HEKVSNQAIVGRLD--ALRRIYVKRDENTMLTRLFELTDG---PTLCMRLGAFTFYKIGSITPKQLKRFHTKDYIFPNNYRITRLFWSPKSHRERMMF 2100 HSP 3 Score: 67.781 bits (164), Expect = 1.610e-10 Identity = 52/186 (27.96%), Postives = 77/186 (41.40%), Query Frame = 1 Query: 3664 LCYSCGSGGD----QLIHCVSCAEPFHFFCIEYQFRPKSKEM---FVCRNCTKCHSCDVYGSD---LKCIKCQLGFHPTC----VDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAGLETIECNSCNRMVHRQCCGLSEDE 4179 +C CGS G ++ C +CA+ +H +C+ + S + + C +CT C C G + L C +C + +H C +DK P + W C C+ C C KA N + + C CA R CP C R YQ + I C+ C++ H C GL DE Sbjct: 427 MCLVCGSIGKGPEGSMVACSNCAQTYHTYCVTLHDKLNSAVVGRGWRCLDCTVCEGCGTGGDEANLLLCDECDVSYHIYCMKPLLDKIP------QGPWRCQWCSRCRRCNHKAASG------NDLTSQ-------GLCFPCASLR----KCPRCERNYQLNEKLIRCSQCSKWQHGACEGLYTDE 589
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Celegans
Match: set-12 (Histone-lysine N-methyltransferase [Source:UniProtKB/TrEMBL;Acc:Q21404]) HSP 1 Score: 90.8929 bits (224), Expect = 1.674e-18 Identity = 50/130 (38.46%), Postives = 73/130 (56.15%), Query Frame = 1 Query: 7714 GRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVD-CYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKV--VRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYL 8094 G GL A + ++I+EY GE I + R Y++ G+ Y F + ++ VD T KGN+ARFINHSC+PN KV V K + I A + I GEE+T+DY +D+ PC CG +C+ ++ Sbjct: 107 GHGLRATEEIATGKLILEYRGEAITKAEHNKRVKRYKKDGIKHSYSFEVGRNYYVDPTRKGNSARFINHSCNPNALVKVWTVPDRPMKSLGIFASKVIKPGEEITFDYGTSFRNDQ-PCQCGEAACRGWI 235
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Fly
Match: trx (gene:FBgn0003862 transcript:FBtr0082947) HSP 1 Score: 196.823 bits (499), Expect = 2.017e-49 Identity = 87/155 (56.13%), Postives = 114/155 (73.55%), Query Frame = 1 Query: 7633 LADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 +A ++R L+ + V V S+IHGRGL+ + +A E++IEY GE+IRS L+D RE Y G+ CYMF++D +L+VDAT +GNAARFINH C PNCY+KVV G KHIII A R+I +GEELTYDY+FP ED+K+PC+CGS C+KYLN Sbjct: 3575 MAMKYRTLK---ETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN 3726 HSP 2 Score: 97.0561 bits (240), Expect = 2.798e-19 Identity = 73/246 (29.67%), Postives = 104/246 (42.28%), Query Frame = 1 Query: 3619 GFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCI--EYQFRPKSKE------------------------------MFVCRNCTKCHSCDVY-GSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GF +I T + LC+ CGS G D LI C C EP+H +C+ EY + S E ++C CT C++C++ GS +KC KCQ +H TC+ D+ C C C C + +KF G + C C + R G+ CP C R Y L+ +EC C + VH +C GLS+++Y + PE S F+C KC Sbjct: 1254 GFGLIVTETVA-QRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRP-LICVNCLKCKSC--------STTKVSKFVGNLPM------CTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGLSDEQYNLLSTLPE----SIEFICKKC 1479 HSP 3 Score: 88.9669 bits (219), Expect = 9.348e-17 Identity = 68/228 (29.82%), Postives = 96/228 (42.11%), Query Frame = 1 Query: 5248 DIRHCALC--AGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDN----------CVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKI-DECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVT 5892 D R C C +G G E RL+Y G D WVH NCA+WS +V+E DG+L NV A+ +G C C GAT+ C+ SC YH+ CA ++ D F ++ YC N VT V P+ + + L + + IG+L + +G I SD + PI + RL+WS E +V Y + T Sbjct: 1733 DTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNV--------RSCGEHYHYPCARSI--DCAFLTDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVELDRKRKKL----------IEPARVQFHIGSLEVRQLGAIVPRFSDSYEA-VVPINFLCSRLYWSSKEPWKIVEYTVRTT 1939
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Fly
Match: trx (gene:FBgn0003862 transcript:FBtr0082950) HSP 1 Score: 196.823 bits (499), Expect = 2.017e-49 Identity = 87/155 (56.13%), Postives = 114/155 (73.55%), Query Frame = 1 Query: 7633 LADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 +A ++R L+ + V V S+IHGRGL+ + +A E++IEY GE+IRS L+D RE Y G+ CYMF++D +L+VDAT +GNAARFINH C PNCY+KVV G KHIII A R+I +GEELTYDY+FP ED+K+PC+CGS C+KYLN Sbjct: 3575 MAMKYRTLK---ETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN 3726 HSP 2 Score: 97.0561 bits (240), Expect = 2.798e-19 Identity = 73/246 (29.67%), Postives = 104/246 (42.28%), Query Frame = 1 Query: 3619 GFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCI--EYQFRPKSKE------------------------------MFVCRNCTKCHSCDVY-GSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GF +I T + LC+ CGS G D LI C C EP+H +C+ EY + S E ++C CT C++C++ GS +KC KCQ +H TC+ D+ C C C C + +KF G + C C + R G+ CP C R Y L+ +EC C + VH +C GLS+++Y + PE S F+C KC Sbjct: 1254 GFGLIVTETVA-QRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRP-LICVNCLKCKSC--------STTKVSKFVGNLPM------CTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGLSDEQYNLLSTLPE----SIEFICKKC 1479 HSP 3 Score: 88.9669 bits (219), Expect = 9.348e-17 Identity = 68/228 (29.82%), Postives = 96/228 (42.11%), Query Frame = 1 Query: 5248 DIRHCALC--AGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDN----------CVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKI-DECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVT 5892 D R C C +G G E RL+Y G D WVH NCA+WS +V+E DG+L NV A+ +G C C GAT+ C+ SC YH+ CA ++ D F ++ YC N VT V P+ + + L + + IG+L + +G I SD + PI + RL+WS E +V Y + T Sbjct: 1733 DTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNV--------RSCGEHYHYPCARSI--DCAFLTDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVELDRKRKKL----------IEPARVQFHIGSLEVRQLGAIVPRFSDSYEA-VVPINFLCSRLYWSSKEPWKIVEYTVRTT 1939
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Fly
Match: trx (gene:FBgn0003862 transcript:FBtr0082948) HSP 1 Score: 192.971 bits (489), Expect = 2.336e-48 Identity = 84/137 (61.31%), Postives = 106/137 (77.37%), Query Frame = 1 Query: 7687 VRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 V V S+IHGRGL+ + +A E++IEY GE+IRS L+D RE Y G+ CYMF++D +L+VDAT +GNAARFINH C PNCY+KVV G KHIII A R+I +GEELTYDY+FP ED+K+PC+CGS C+KYLN Sbjct: 3222 VGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN 3358 HSP 2 Score: 97.0561 bits (240), Expect = 2.668e-19 Identity = 73/246 (29.67%), Postives = 103/246 (41.87%), Query Frame = 1 Query: 3619 GFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCI--EYQFRPKSKE------------------------------MFVCRNCTKCHSCDVY-GSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GF +I T + LC+ CGS G D LI C C EP+H +C+ EY + S E ++C CT C++C++ GS +KC KCQ +H TC+ D+ C C C C +KF G + C C + R G+ CP C R Y L+ +EC C + VH +C GLS+++Y + PE S F+C KC Sbjct: 886 GFGLIVTETVA-QRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRP-LICVNCLKCKSCSTT--------KVSKFVGNLPM------CTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGLSDEQYNLLSTLPE----SIEFICKKC 1111 HSP 3 Score: 88.9669 bits (219), Expect = 9.230e-17 Identity = 68/228 (29.82%), Postives = 96/228 (42.11%), Query Frame = 1 Query: 5248 DIRHCALC--AGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDN----------CVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKI-DECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVT 5892 D R C C +G G E RL+Y G D WVH NCA+WS +V+E DG+L NV A+ +G C C GAT+ C+ SC YH+ CA ++ D F ++ YC N VT V P+ + + L + + IG+L + +G I SD + PI + RL+WS E +V Y + T Sbjct: 1365 DTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNV--------RSCGEHYHYPCARSI--DCAFLTDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVELDRKRKKL----------IEPARVQFHIGSLEVRQLGAIVPRFSDSYEA-VVPINFLCSRLYWSSKEPWKIVEYTVRTT 1571
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Fly
Match: trx (gene:FBgn0003862 transcript:FBtr0082949) HSP 1 Score: 192.971 bits (489), Expect = 2.336e-48 Identity = 84/137 (61.31%), Postives = 106/137 (77.37%), Query Frame = 1 Query: 7687 VRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 V V S+IHGRGL+ + +A E++IEY GE+IRS L+D RE Y G+ CYMF++D +L+VDAT +GNAARFINH C PNCY+KVV G KHIII A R+I +GEELTYDY+FP ED+K+PC+CGS C+KYLN Sbjct: 3222 VGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN 3358 HSP 2 Score: 97.0561 bits (240), Expect = 2.668e-19 Identity = 73/246 (29.67%), Postives = 103/246 (41.87%), Query Frame = 1 Query: 3619 GFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCI--EYQFRPKSKE------------------------------MFVCRNCTKCHSCDVY-GSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GF +I T + LC+ CGS G D LI C C EP+H +C+ EY + S E ++C CT C++C++ GS +KC KCQ +H TC+ D+ C C C C +KF G + C C + R G+ CP C R Y L+ +EC C + VH +C GLS+++Y + PE S F+C KC Sbjct: 886 GFGLIVTETVA-QRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRP-LICVNCLKCKSCSTT--------KVSKFVGNLPM------CTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGLSDEQYNLLSTLPE----SIEFICKKC 1111 HSP 3 Score: 88.9669 bits (219), Expect = 9.230e-17 Identity = 68/228 (29.82%), Postives = 96/228 (42.11%), Query Frame = 1 Query: 5248 DIRHCALC--AGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDN----------CVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKI-DECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVT 5892 D R C C +G G E RL+Y G D WVH NCA+WS +V+E DG+L NV A+ +G C C GAT+ C+ SC YH+ CA ++ D F ++ YC N VT V P+ + + L + + IG+L + +G I SD + PI + RL+WS E +V Y + T Sbjct: 1365 DTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNV--------RSCGEHYHYPCARSI--DCAFLTDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVELDRKRKKL----------IEPARVQFHIGSLEVRQLGAIVPRFSDSYEA-VVPINFLCSRLYWSSKEPWKIVEYTVRTT 1571
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Fly
Match: trx (gene:FBgn0003862 transcript:FBtr0100277) HSP 1 Score: 192.971 bits (489), Expect = 2.336e-48 Identity = 84/137 (61.31%), Postives = 106/137 (77.37%), Query Frame = 1 Query: 7687 VRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 V V S+IHGRGL+ + +A E++IEY GE+IRS L+D RE Y G+ CYMF++D +L+VDAT +GNAARFINH C PNCY+KVV G KHIII A R+I +GEELTYDY+FP ED+K+PC+CGS C+KYLN Sbjct: 3222 VGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHCCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN 3358 HSP 2 Score: 97.0561 bits (240), Expect = 2.668e-19 Identity = 73/246 (29.67%), Postives = 103/246 (41.87%), Query Frame = 1 Query: 3619 GFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCI--EYQFRPKSKE------------------------------MFVCRNCTKCHSCDVY-GSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GF +I T + LC+ CGS G D LI C C EP+H +C+ EY + S E ++C CT C++C++ GS +KC KCQ +H TC+ D+ C C C C +KF G + C C + R G+ CP C R Y L+ +EC C + VH +C GLS+++Y + PE S F+C KC Sbjct: 886 GFGLIVTETVA-QRALCFLCGSTGLDPLIFCACCCEPYHQYCVQDEYNLKHGSFEDTTLMGSLLETTVNASTGPSSSLNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRP-LICVNCLKCKSCSTT--------KVSKFVGNLPM------CTGCFKLRKKGNFCPICQRCYDDNDFDLKMMECGDCGQWVHSKCEGLSDEQYNLLSTLPE----SIEFICKKC 1111 HSP 3 Score: 88.9669 bits (219), Expect = 9.230e-17 Identity = 68/228 (29.82%), Postives = 96/228 (42.11%), Query Frame = 1 Query: 5248 DIRHCALC--AGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDN----------CVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKI-DECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVT 5892 D R C C +G G E RL+Y G D WVH NCA+WS +V+E DG+L NV A+ +G C C GAT+ C+ SC YH+ CA ++ D F ++ YC N VT V P+ + + L + + IG+L + +G I SD + PI + RL+WS E +V Y + T Sbjct: 1365 DTRMCLFCRKSGEGLSGEEARLLYCGHDCWVHTNCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNV--------RSCGEHYHYPCARSI--DCAFLTDKSMYCPAHAKNGNALKANGSPSVTYESNFEVSRPVYVELDRKRKKL----------IEPARVQFHIGSLEVRQLGAIVPRFSDSYEA-VVPINFLCSRLYWSSKEPWKIVEYTVRTT 1571
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Zebrafish
Match: kmt2a (lysine (K)-specific methyltransferase 2A [Source:ZFIN;Acc:ZDB-GENE-080521-3]) HSP 1 Score: 234.187 bits (596), Expect = 1.184e-60 Identity = 132/326 (40.49%), Postives = 177/326 (54.29%), Query Frame = 1 Query: 7144 RKQRANHDYKFCLRFTI---HGFK-GSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPP--KNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 R +H K L F I GF+ +S + W + ++ + R + L +G G+ H V++L+EQ+ A C NY F+FHK T YL V+PHG R + + D FL SK PP + + L ++FR L+ A V V S IHGRGLF R+ + E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GN+ARFINHSC PNCY++VV +G+KHI+I A RKIYKGEELTYDY+FPIE+ +KLPC CG+ C+K+LN Sbjct: 3906 RDSSLDHKPKKGLIFEICSDDGFQIRCESIEEAWKSLTDKVQEARSNARLKALSFDGVNGLKMLGVVHDAVVFLLEQLYGARHCRNYRFRFHKPEET----DYLP--VNPHGSARAEVYHRKS----VLDMFNFLASKHRQPPVYNPQEEDEEEMQQKSARRATSTDLPLPEKFRQLKK---ASRDAVGVYRSAIHGRGLFCRKNIEPGEMVIEYSGNVIRSVLTDKREKYYDDKGIGCYMFRIDDYEVVDATIHGNSARFINHSCEPNCYSRVVNVDGQKHIVIFATRKIYKGEELTYDYKFPIEEPGNKLPCNCGAKKCRKFLN 4218 HSP 2 Score: 138.658 bits (348), Expect = 1.158e-31 Identity = 80/213 (37.56%), Postives = 114/213 (53.52%), Query Frame = 1 Query: 5248 DIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLP-QGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 D R CALC GD++ GRL+Y G + W HVNCALWS +VYE DGAL NV +A+ +G++ C C K GAT+ C C +SC N YHF CA F E + YC + H + V + + RR+ + +G + +G+ DNI + IG++ I+C+G + E SD R L P+GYQ R++WS + +Y Sbjct: 2064 DNRQCALCLNYGDEKTNDCGRLLYIGHNEWAHVNCALWSAEVYEDVDGALKNVHMAVSRGKQLQCKNCHKPGATVSC--------CMTSCTNNYHFMCARQQ--QCAFLEDKKVYC-QHHKDLVKGEVVPESSFEVTRRVLVDFEGI--RLRRKFVNGLEPDNIHMVIGSMTIDCLGMLTELSDCER-KLFPVGYQCSRVYWSTLDARKRCVY 2262 HSP 3 Score: 116.316 bits (290), Expect = 6.121e-25 Identity = 75/225 (33.33%), Postives = 106/225 (47.11%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSK--EMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSDDKSN-WACYKCAMCLHCGA----KAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQA---GLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +V+C+ C S G+ + + C C EPFH FC+ RP + E + CR C CH C L+C KC+ +HP C+ PTR K W C KC C CGA KA DA WS D C CA+ G++CP C + Y + ++C C+R VH +C L++D E+ + PE + + CT C Sbjct: 1612 GGLSILTSVPITP-RVVCFLCASSGNVEFVFCQVCCEPFHLFCLGEAERPHDEQWENWCCRRCRFCHVCGRKYQKTKQLLECDKCRNSYHPECLGPNHPTRPTKKKRVWVCTKCVRCKSCGATKPGKAWDAQ-------------WSHDFSLCHDCAKRLTKGNLCPLCNKGYDDDDCDSKMMKCKKCDRWVHAKCESLTDDMCELMSSLPE----NVVYTCTNC 1818
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Zebrafish
Match: kmt2a (lysine (K)-specific methyltransferase 2A [Source:ZFIN;Acc:ZDB-GENE-080521-3]) HSP 1 Score: 234.187 bits (596), Expect = 1.235e-60 Identity = 132/326 (40.49%), Postives = 177/326 (54.29%), Query Frame = 1 Query: 7144 RKQRANHDYKFCLRFTI---HGFK-GSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPP--KNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 R +H K L F I GF+ +S + W + ++ + R + L +G G+ H V++L+EQ+ A C NY F+FHK T YL V+PHG R + + D FL SK PP + + L ++FR L+ A V V S IHGRGLF R+ + E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GN+ARFINHSC PNCY++VV +G+KHI+I A RKIYKGEELTYDY+FPIE+ +KLPC CG+ C+K+LN Sbjct: 3907 RDSSLDHKPKKGLIFEICSDDGFQIRCESIEEAWKSLTDKVQEARSNARLKALSFDGVNGLKMLGVVHDAVVFLLEQLYGARHCRNYRFRFHKPEET----DYLP--VNPHGSARAEVYHRKS----VLDMFNFLASKHRQPPVYNPQEEDEEEMQQKSARRATSTDLPLPEKFRQLKK---ASRDAVGVYRSAIHGRGLFCRKNIEPGEMVIEYSGNVIRSVLTDKREKYYDDKGIGCYMFRIDDYEVVDATIHGNSARFINHSCEPNCYSRVVNVDGQKHIVIFATRKIYKGEELTYDYKFPIEEPGNKLPCNCGAKKCRKFLN 4219 HSP 2 Score: 138.658 bits (348), Expect = 1.139e-31 Identity = 80/213 (37.56%), Postives = 114/213 (53.52%), Query Frame = 1 Query: 5248 DIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLP-QGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 D R CALC GD++ GRL+Y G + W HVNCALWS +VYE DGAL NV +A+ +G++ C C K GAT+ C C +SC N YHF CA F E + YC + H + V + + RR+ + +G + +G+ DNI + IG++ I+C+G + E SD R L P+GYQ R++WS + +Y Sbjct: 2064 DNRQCALCLNYGDEKTNDCGRLLYIGHNEWAHVNCALWSAEVYEDVDGALKNVHMAVSRGKQLQCKNCHKPGATVSC--------CMTSCTNNYHFMCARQQ--QCAFLEDKKVYC-QHHKDLVKGEVVPESSFEVTRRVLVDFEGI--RLRRKFVNGLEPDNIHMVIGSMTIDCLGMLTELSDCER-KLFPVGYQCSRVYWSTLDARKRCVY 2262 HSP 3 Score: 116.316 bits (290), Expect = 6.070e-25 Identity = 75/225 (33.33%), Postives = 106/225 (47.11%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSK--EMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSDDKSN-WACYKCAMCLHCGA----KAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQA---GLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +V+C+ C S G+ + + C C EPFH FC+ RP + E + CR C CH C L+C KC+ +HP C+ PTR K W C KC C CGA KA DA WS D C CA+ G++CP C + Y + ++C C+R VH +C L++D E+ + PE + + CT C Sbjct: 1612 GGLSILTSVPITP-RVVCFLCASSGNVEFVFCQVCCEPFHLFCLGEAERPHDEQWENWCCRRCRFCHVCGRKYQKTKQLLECDKCRNSYHPECLGPNHPTRPTKKKRVWVCTKCVRCKSCGATKPGKAWDAQ-------------WSHDFSLCHDCAKRLTKGNLCPLCNKGYDDDDCDSKMMKCKKCDRWVHAKCESLTDDMCELMSSLPE----NVVYTCTNC 1818
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Zebrafish
Match: kmt2bb (lysine (K)-specific methyltransferase 2Bb [Source:ZFIN;Acc:ZDB-GENE-080521-1]) HSP 1 Score: 219.935 bits (559), Expect = 2.260e-56 Identity = 126/314 (40.13%), Postives = 175/314 (55.73%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKN--HAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G + S + W +++ + + R + GL + G G+ H V+YLVEQ+ A +C+ + F+FHK +Q V+P GC R + + D FL S+ P + + L + +A +FR+L + V V S IHGRGLF +R +A E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ EG+KHI+I A RKIY+GEELTYDY+FPIED +KL C CG+ C+++LN Sbjct: 3440 LRFEIASDDGFSIEADSIEVAWSAVLEGVQEARAAAGLRLLTMCGMSGARVMGMLHDAVVYLVEQLQGAKRCHRHTFRFHKQA-----SQDDDLPVNPSGCARSEVYLRKS----TFDMFNFLASQHRQLPDTDLYDEEEDEVLLKSTRRATSLELPMAMRFRHLER---TSKEAVGVYRSAIHGRGLFCKRNIEAGEMVIEYSGIVIRSVLTDKREKYYDGKGIGCYMFRIDDFDVVDATMHGNAARFINHSCEPNCYSRVINVEGQKHIVIFALRKIYRGEELTYDYKFPIEDASNKLGCNCGAKRCRRFLN 3741 HSP 2 Score: 118.627 bits (296), Expect = 1.016e-25 Identity = 72/228 (31.58%), Postives = 118/228 (51.75%), Query Frame = 1 Query: 5218 SEFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVTK 5895 S+ + + D R CALC GD + GRL+Y G + W HVNC++WS +V+E ++G+L++V A+ +G C C + GAT+ C C SSC + YHF CA + VF + + +C + H + ++ +T +LRR+Y+ ++ + G+ ++I + IG+L + +GK+ E S L P+GY+ R FWS Y VT+ Sbjct: 2036 SDLETGWSKDDERQCALCQKYGDAKASDAGRLLYLGQNEWAHVNCSMWSAEVFEEDNGSLLHVHSAVARGRLMRCERCNRTGATVGC--------CLSSCQSNYHFMCA--RFRNCVFQDDKKVFCYK-HRDLISGKMITGQGFEVLRRVYVDFEGIS-LRRKFLTGLEPESINLMIGSLLVEKLGKLSELS-ACDGKLFPVGYECSRWFWSTVNPLRRCKYTFRVTE 2250 HSP 3 Score: 83.9593 bits (206), Expect = 3.769e-15 Identity = 61/218 (27.98%), Postives = 92/218 (42.20%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRP--KSKEMFVCRNCTKCHSCDVYGSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKCQP 4251 GG V+T+V P+ +C C S G +++ C C EPFH FC++ RP ++KE + CR C C C +K + C C C CG T S + +W+ D C C R G+ C C + Y+ + ++C++CN VH +C GL++D YEI + PE+ + CQP Sbjct: 1639 GGLSVLTSVPLMPS-CVCLLCASKGQHEMLFCQVCCEPFHRFCLDPSERPLEENKENWCCRRCKFCRVCG---------------------------RKNKESKVCMTCIRCRSCGV----------TPGKSWDTEWNHDKGLCPDCTRLFDQGNYCTMCFKCYEDNDYDSQMMQCSTCNHWVHAKCEGLTDDLYEILSSLPES-------VVYSCQP 1811
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Zebrafish
Match: kmt2bb (lysine (K)-specific methyltransferase 2Bb [Source:ZFIN;Acc:ZDB-GENE-080521-1]) HSP 1 Score: 219.55 bits (558), Expect = 2.820e-56 Identity = 126/314 (40.13%), Postives = 175/314 (55.73%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKN--HAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G + S + W +++ + + R + GL + G G+ H V+YLVEQ+ A +C+ + F+FHK +Q V+P GC R + + D FL S+ P + + L + +A +FR+L + V V S IHGRGLF +R +A E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ EG+KHI+I A RKIY+GEELTYDY+FPIED +KL C CG+ C+++LN Sbjct: 3471 LRFEIASDDGFSIEADSIEVAWSAVLEGVQEARAAAGLRLLTMCGMSGARVMGMLHDAVVYLVEQLQGAKRCHRHTFRFHKQA-----SQDDDLPVNPSGCARSEVYLRKS----TFDMFNFLASQHRQLPDTDLYDEEEDEVLLKSTRRATSLELPMAMRFRHLER---TSKEAVGVYRSAIHGRGLFCKRNIEAGEMVIEYSGIVIRSVLTDKREKYYDGKGIGCYMFRIDDFDVVDATMHGNAARFINHSCEPNCYSRVINVEGQKHIVIFALRKIYRGEELTYDYKFPIEDASNKLGCNCGAKRCRRFLN 3772 HSP 2 Score: 118.627 bits (296), Expect = 1.106e-25 Identity = 72/228 (31.58%), Postives = 118/228 (51.75%), Query Frame = 1 Query: 5218 SEFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVTK 5895 S+ + + D R CALC GD + GRL+Y G + W HVNC++WS +V+E ++G+L++V A+ +G C C + GAT+ C C SSC + YHF CA + VF + + +C + H + ++ +T +LRR+Y+ ++ + G+ ++I + IG+L + +GK+ E S L P+GY+ R FWS Y VT+ Sbjct: 2067 SDLETGWSKDDERQCALCQKYGDAKASDAGRLLYLGQNEWAHVNCSMWSAEVFEEDNGSLLHVHSAVARGRLMRCERCNRTGATVGC--------CLSSCQSNYHFMCA--RFRNCVFQDDKKVFCYK-HRDLISGKMITGQGFEVLRRVYVDFEGIS-LRRKFLTGLEPESINLMIGSLLVEKLGKLSELS-ACDGKLFPVGYECSRWFWSTVNPLRRCKYTFRVTE 2281 HSP 3 Score: 111.694 bits (278), Expect = 1.508e-23 Identity = 70/222 (31.53%), Postives = 105/222 (47.30%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRP--KSKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKCQP 4251 GG V+T+V P+ +C C S G +++ C C EPFH FC++ RP ++KE + CR C C C + L+C +CQ +HP C+ P + K W C C C CG T S + +W+ D C C R G+ C C + Y+ + ++C++CN VH +C GL++D YEI + PE+ + CQP Sbjct: 1639 GGLSVLTSVPLMPS-CVCLLCASKGQHEMLFCQVCCEPFHRFCLDPSERPLEENKENWCCRRCKFCRVCGRKNKESKPLLECERCQNCYHPACLGPNYPKPNKRKKPWVCMTCIRCRSCGV----------TPGKSWDTEWNHDKGLCPDCTRLFDQGNYCTMCFKCYEDNDYDSQMMQCSTCNHWVHAKCEGLTDDLYEILSSLPES-------VVYSCQP 1842
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Zebrafish
Match: kmt2ba (lysine (K)-specific methyltransferase 2Ba [Source:ZFIN;Acc:ZDB-GENE-060503-376]) HSP 1 Score: 214.927 bits (546), Expect = 7.168e-55 Identity = 114/294 (38.78%), Postives = 168/294 (57.14%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIE--DDKLPCTCGSFSCKKYLN 8097 W ++ + + R + + P + +G G+ H V++L+EQ+ A C + F+FH+ + + + L + +P+GC R + + D FL S+ P++ + + L A +FR+L + V V S IHGRGLF +R +A E++IEY G VIR++L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ EG+KHI+I A RKIY+GEELTYDY+FPIE D+KL C CG+ C+++LN Sbjct: 2664 AWKAVMDGVQEARIGCRMEQLPFNSINGARVLGVLHDAVLFLLEQLQGASLCQKHRFRFHQHEIPE---EELPE--NPNGCARAEVYVRKS----TFDMFNFLASQHRQLPESRPCDDDEDDIMLKSSRRATSTELPVAMRFRHLEK---TSKEAVGVYRSAIHGRGLFCKRNIEAGEMVIEYAGNVIRAVLTDKREKYYDSKGIGCYMFRIDDFDVVDATMHGNAARFINHSCDPNCYSRVINVEGQKHIVIFALRKIYRGEELTYDYKFPIEDADNKLHCNCGARRCRRFLN 2945 HSP 2 Score: 98.5969 bits (244), Expect = 1.344e-19 Identity = 60/202 (29.70%), Postives = 91/202 (45.05%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPK--SKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQA---GLETIECNSCNRMVHRQCCGLSEDEYEIF 4191 GG ++T+V P + +C C S G ++++C C EPFH FC+ RPK +KE + CR C CH C L+C +C +HP+C+ P ++W C C C CG T S + W+ + C C + G C C + Y+ ++C C VH +C GL++D +EI Sbjct: 1083 GGLSILTSVPIMP-QCVCLLCASKGQHEMVYCQMCCEPFHHFCLPPDDRPKEENKENWCCRRCKFCHVCGRKSKQTKPVLQCKRCMYCYHPSCLGPTYPKPVKMNTSWVCMLCIRCKSCGV----------TPGKSSDTSWNHELELCPDCNKLHSKGDFCTVCLKCYEEHEFDSSMMQCARCAHWVHPKCEGLTDDLHEIL 1273 HSP 3 Score: 97.8265 bits (242), Expect = 1.945e-19 Identity = 87/307 (28.34%), Postives = 144/307 (46.91%), Query Frame = 1 Query: 4951 MVVKKYSGRAKLIMQALAENVRDNIN-REFDVFSSSITEIEEKLSNSFQRGR-EEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECS-DYLRVYLCPIGYQARRLFWSMYE 5856 + ++ + +AKL L E V N ++ +SS++ E F RG E II S +H + + ++ Q+ S + NS D R C+LC GD + GRL+Y G + W HVNC +WS +V E +GAL++V A+ +G C C + GAT+ C C +SC + YHF CA + VF + YC + H + ++RR+Y+ ++ + G+ +++ V IG+L + +G + E S + ++Y P+GYQ R +WS + Sbjct: 1384 LEAQRPTSQAKLYYIKLVEQVFSWFNSQDPKTWSSNVQE--------FPRGMLPEAIIPPSNEH--SYAQWLKDQHPGSPQSKDQQKI------NSKPL--DERQCSLCQQHGDAKPNDAGRLLYIGQNEWAHVNCCIWSAEVQE-TNGALLHVHSAVARGRFMRCERCGQTGATVGC--------CLTSCQSNYHFMCA--RASNCVFQHDKKVYCYK-HRELINSKIEQGNGFEVVRRVYVDFDGIS-LRRKFLTGLEPESVNVMIGSLHVKNLGVLTELSANSGKLY--PVGYQCSRWYWSTVD 1657
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Xenopus
Match: ralgapa2 (Ral GTPase activating protein, alpha subunit 2 (catalytic) [Source:Xenbase;Acc:XB-GENE-957487]) HSP 1 Score: 236.498 bits (602), Expect = 3.736e-61 Identity = 127/313 (40.58%), Postives = 173/313 (55.27%), Query Frame = 1 Query: 7171 KFCLRFTIHGFKGSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPP--KNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 K L F I G + W + +++ + R + L + G G+ H V++LVEQ+ A +C NY+F+FH+ + ++PHG R + A D FL SK PP K + + + + +FR+L+ + V V S IHGRGLF RR DA E++IEY G VIRSIL+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A RKIY+GEELTYDY+FPIED +KL C CG+ C+K+LN Sbjct: 3365 KTGLLFEISSDDGFQISAEAWKSLTEKVQEARSNARLKQLSFAGVSGLRMLGIVHDAVVFLVEQLYGANRCRNYKFRFHRPEGEE------EPPINPHGSARAEVHRRKS----AFDMFNFLASKHRQPPEYKPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKK---TSKEAVGVYRSPIHGRGLFCRRNIDAGEMVIEYSGNVIRSILTDKREKYYDGKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVIPIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDANNKLACNCGTKKCRKFLN 3664 HSP 2 Score: 112.849 bits (281), Expect = 9.014e-24 Identity = 72/221 (32.58%), Postives = 105/221 (47.51%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSKEM--FVCRNCTKCHSC----DVYGSDLKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG ++TT P +V+C+ C S G + ++C C EPFH FC+E + RP ++ + CR+C CH C L+C KC+ +HP C+ YP + K W C KC C CG+ T + WS D C CA+ G+ CP C + Y + ++C C+R VH +C L+++ YEI PE S A+ C C Sbjct: 1348 GGISLLTTAPVTP-RVVCFLCASSGHVEFVYCQVCCEPFHRFCLEERERPSEDQIENWCCRHCKFCHVCGRQQQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKRVWICTKCVRCKSCGS---------TTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCNKCYDDDDYESKMMQCGKCDRWVHSKCENLTDEMYEILSNLPE----SVAYTCINC 1554
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Xenopus
Match: kmt2b (lysine methyltransferase 2B [Source:NCBI gene;Acc:100144721]) HSP 1 Score: 219.55 bits (558), Expect = 3.542e-56 Identity = 124/315 (39.37%), Postives = 172/315 (54.60%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGD-GWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G + S + W +++++ + R L + G FG+ H V++L+EQ+ A +C Y+F FH V + +P GC R + + D FL S+ P+ ++ L A +FR+L+ + V V S IHGRGLF +R DA E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ EG+KHI+I A R IY+GEELTYDY+FPIED +KLPC CG+ C+++LN Sbjct: 2515 LRFEITSEDGFYIQADSAEDAWKAVLEKVQETRGVGKLRHLSLSASMIGTRMFGVQHDAVLFLLEQLTGAERCRGYKFLFHPQEVEEGEIS-----TNPSGCARSEVYVRKS----TFDMFNFLASQHRTLPEIGPCEEEEEEVQLKSTRRATSLDLPMAMRFRHLKK---TSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGCYMFRIDDFDVVDATMHGNAARFINHSCEPNCYSRVIHVEGQKHIVIFALRSIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRRFLN 2817 HSP 2 Score: 120.168 bits (300), Expect = 5.862e-26 Identity = 74/225 (32.89%), Postives = 116/225 (51.56%), Query Frame = 1 Query: 5248 DIRHCALCAGSGDD--RLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECS-DYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVTKELNN 5907 D R CALC GDD + GRL+Y G + W H+NCA+WS +V+E DG+L NV A+ +G + C CQK GAT+ C C S+C + +HF CA F + + +CS+ H + + +LRR+Y+ +S G+ D+I + IG+++I+ +G +++ S ++Y P+GYQ RL+WS + Y V + N Sbjct: 1613 DTRQCALCLKYGDDDPKDAGRLLYIGQNEWTHINCAIWSAEVFEENDGSLKNVHAAVARGRQLRCDNCQKIGATVGC--------CLSTCHSNFHFMCARAS--RCCFQDDKKMFCSK-HTKLLDGTPVEEDCFDVLRRVYVD---FEGISFRRKFLQGLEPDHIHMMIGSMKIDSLGMLNDLSVTEGKIY--PVGYQCSRLYWSTQDARRQCWYKCRVLEHCPN 1821 HSP 3 Score: 107.457 bits (267), Expect = 3.507e-22 Identity = 68/222 (30.63%), Postives = 102/222 (45.95%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFRPKSKE--MFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCG-AKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG V+T+V P ++C C S G +L++C C EPFH FC+E RP + + CR C C+ C G L+C CQ +H C+ YP W C C C CG A +D G+++ ++D C C+ G+ CP C R Y+ + I+C C++ +H +C GLS++ YE+ P+ S + C C Sbjct: 1218 GGLSVLTSVPVNPT-LMCLLCASRGRHKLLYCQVCCEPFHRFCLEESERPLPNQEGTWCCRRCKFCNVCGQKGKAKKPLLECELCQTNYHVNCLGPNYPLKAPRSGKGWTCSACIRCRSCGIAPGKD-----------GDLELTEDSKLCSECSTLYDKGNFCPICIRCYEESEYESKMIQCAKCDKWIHSKCEGLSDEGYELLSNLPD----SVVYTCPPC 1423
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Xenopus
Match: kmt2b (lysine methyltransferase 2B [Source:NCBI gene;Acc:100144721]) HSP 1 Score: 219.55 bits (558), Expect = 4.007e-56 Identity = 124/315 (39.37%), Postives = 172/315 (54.60%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGD-GWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G + S + W +++++ + R L + G FG+ H V++L+EQ+ A +C Y+F FH V + +P GC R + + D FL S+ P+ ++ L A +FR+L+ + V V S IHGRGLF +R DA E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ EG+KHI+I A R IY+GEELTYDY+FPIED +KLPC CG+ C+++LN Sbjct: 2385 LRFEITSEDGFYIQADSAEDAWKAVLEKVQETRGVGKLRHLSLSASMIGTRMFGVQHDAVLFLLEQLTGAERCRGYKFLFHPQEVEEGEIS-----TNPSGCARSEVYVRKS----TFDMFNFLASQHRTLPEIGPCEEEEEEVQLKSTRRATSLDLPMAMRFRHLKK---TSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGCYMFRIDDFDVVDATMHGNAARFINHSCEPNCYSRVIHVEGQKHIVIFALRSIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRRFLN 2687 HSP 2 Score: 107.457 bits (267), Expect = 3.841e-22 Identity = 68/222 (30.63%), Postives = 102/222 (45.95%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFRPKSKE--MFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCG-AKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG V+T+V P ++C C S G +L++C C EPFH FC+E RP + + CR C C+ C G L+C CQ +H C+ YP W C C C CG A +D G+++ ++D C C+ G+ CP C R Y+ + I+C C++ +H +C GLS++ YE+ P+ S + C C Sbjct: 1186 GGLSVLTSVPVNPT-LMCLLCASRGRHKLLYCQVCCEPFHRFCLEESERPLPNQEGTWCCRRCKFCNVCGQKGKAKKPLLECELCQTNYHVNCLGPNYPLKAPRSGKGWTCSACIRCRSCGIAPGKD-----------GDLELTEDSKLCSECSTLYDKGNFCPICIRCYEESEYESKMIQCAKCDKWIHSKCEGLSDEGYELLSNLPD----SVVYTCPPC 1391 HSP 3 Score: 106.686 bits (265), Expect = 5.894e-22 Identity = 65/206 (31.55%), Postives = 106/206 (51.46%), Query Frame = 1 Query: 5299 GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECS-DYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVTKELNN 5907 GRL+Y G + W H+NCA+WS +V+E DG+L NV A+ +G + C CQK GAT+ C C S+C + +HF CA F + + +CS+ H + + +LRR+Y+ +S G+ D+I + IG+++I+ +G +++ S ++Y P+GYQ RL+WS + Y V + N Sbjct: 1502 GRLLYIGQNEWTHINCAIWSAEVFEENDGSLKNVHAAVARGRQLRCDNCQKIGATVGC--------CLSTCHSNFHFMCARAS--RCCFQDDKKMFCSK-HTKLLDGTPVEEDCFDVLRRVYVD---FEGISFRRKFLQGLEPDHIHMMIGSMKIDSLGMLNDLSVTEGKIY--PVGYQCSRLYWSTQDARRQCWYKCRVLEHCPN 1691
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Xenopus
Match: c1orf50 (chromosome 1 open reading frame 50 [Source:Xenbase;Acc:XB-GENE-1004912]) HSP 1 Score: 157.918 bits (398), Expect = 1.694e-40 Identity = 98/300 (32.67%), Postives = 158/300 (52.67%), Query Frame = 1 Query: 7216 SPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKS----NYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDD--KLPCTCGSFSCKKYLN 8097 SP++ W + + + +MR+ G++ G FGL V+ + E + C NY F++ K + +L +++P GC R +P H K N + A + + N + ++ + + Q+R L+ R S I G GL+A + + H ++IEY+G +IR+ +++ RE Y+ YMFR++ + ++DAT G AR+INHSC PNC A+VV F+ E IIII+ R+I KGEELTYDY+F EDD K+PC CG+++C+K++N Sbjct: 129 SPQALWNRVAEPVARMRRETGMLRLFPEYLKGEEMFGLTVHAVLRIAESLPGVENCQNYLFRYGKHPLMEL-----PLMINPTGCAR-------------SEPKIMTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLKTEWKTNVYLAR---SRIQGLGLYASKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN 407
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Xenopus
Match: setd1b (SET domain containing 1B [Source:NCBI gene;Acc:780106]) HSP 1 Score: 166.777 bits (421), Expect = 3.134e-40 Identity = 77/147 (52.38%), Postives = 104/147 (70.75%), Query Frame = 1 Query: 7660 NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 N + R K +R C S+IH GLFA A E++IEYVG+ IR +++D+RE Y+ G+ YMFR+D D I+DAT GN ARFINHSC+PNCYAKV+ E +K I+I +++ I EE+TYDY+FPIED K+PC CG+ +C+ LN Sbjct: 1816 NQLKFRKKKLRFCKSHIHDWGLFAMEPIIADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQYINVNEEITYDYKFPIEDVKIPCLCGAENCRGTLN 1962
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Mouse
Match: Kmt2a (lysine (K)-specific methyltransferase 2A [Source:MGI Symbol;Acc:MGI:96995]) HSP 1 Score: 236.498 bits (602), Expect = 2.533e-61 Identity = 120/292 (41.10%), Postives = 163/292 (55.82%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 W + ++ + R + L + +G G+ H V++L+EQ+ A C NY+F+FHK + ++PHG R + A D FL SK PP+ + ++ L R R+ + V V S IHGRGLF +R DA E++IEY G VIRSI +D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A RKIY+GEELTYDY+FPIED +KLPC CG+ C+K+LN Sbjct: 3686 AWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRFHKP------EEANEPPLNPHGSARAEVHLR----QSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR-FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 3966 HSP 2 Score: 130.954 bits (328), Expect = 2.241e-29 Identity = 77/223 (34.53%), Postives = 120/223 (53.81%), Query Frame = 1 Query: 5221 EFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 E N D R CALC GDD GRL+Y G + W HVNCALWS +V+E +DG+L NV +A+ +G++ C CQK GAT+ C C +SC + YHF C+ + VF + + YC + H + + + + RR+++ +S+ +G+ +NI + IG++ I+C+G +++ SD L PIGYQ R++WS + +Y Sbjct: 1862 ELNPPPGIDDNRQCALCLMYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGC--------CLTSCTSNYHFMCSRAK--NCVFLDDKKVYC-QRHRDLIKGEVVPENGFEVFRRVFV---DFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSD-CEDKLFPIGYQCSRVYWSTTDARKRCVY 2069 HSP 3 Score: 102.834 bits (255), Expect = 6.982e-21 Identity = 75/224 (33.48%), Postives = 104/224 (46.43%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSKEM--FVCRNCTKCHSC----DVYGSDLKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCP---ECGRAYQAGLETIECNSCNRMVHRQCCGLS--EDE-YEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +V+C+ C S G + ++C C EPFH FC+E RP ++ + CR C CH C L+C KC+ +HP C+ YP + K W C KC C CG+ T + WS D C CA+ G+ CP +C + ++C C+R VH +C LS EDE YEI PE S A+ C C Sbjct: 1417 GGLGILTSVPITP-RVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGS---------TTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCESLSGTEDEMYEILSNLPE----SVAYTCVNC 1626
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Mouse
Match: Kmt2a (lysine (K)-specific methyltransferase 2A [Source:MGI Symbol;Acc:MGI:96995]) HSP 1 Score: 236.498 bits (602), Expect = 2.664e-61 Identity = 120/292 (41.10%), Postives = 163/292 (55.82%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 W + ++ + R + L + +G G+ H V++L+EQ+ A C NY+F+FHK + ++PHG R + A D FL SK PP+ + ++ L R R+ + V V S IHGRGLF +R DA E++IEY G VIRSI +D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A RKIY+GEELTYDY+FPIED +KLPC CG+ C+K+LN Sbjct: 3683 AWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRFHKP------EEANEPPLNPHGSARAEVHLR----QSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR-FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 3963 HSP 2 Score: 130.954 bits (328), Expect = 2.061e-29 Identity = 77/223 (34.53%), Postives = 120/223 (53.81%), Query Frame = 1 Query: 5221 EFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 E N D R CALC GDD GRL+Y G + W HVNCALWS +V+E +DG+L NV +A+ +G++ C CQK GAT+ C C +SC + YHF C+ + VF + + YC + H + + + + RR+++ +S+ +G+ +NI + IG++ I+C+G +++ SD L PIGYQ R++WS + +Y Sbjct: 1859 ELNPPPGIDDNRQCALCLMYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGC--------CLTSCTSNYHFMCSRAK--NCVFLDDKKVYC-QRHRDLIKGEVVPENGFEVFRRVFV---DFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSD-CEDKLFPIGYQCSRVYWSTTDARKRCVY 2066 HSP 3 Score: 106.686 bits (265), Expect = 5.689e-22 Identity = 72/221 (32.58%), Postives = 103/221 (46.61%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSKEM--FVCRNCTKCHSC----DVYGSDLKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCP---ECGRAYQAGLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +V+C+ C S G + ++C C EPFH FC+E RP ++ + CR C CH C L+C KC+ +HP C+ YP + K W C KC C CG+ T + WS D C CA+ G+ CP +C + ++C C+R VH +C LS++ YEI PE S A+ C C Sbjct: 1417 GGLGILTSVPITP-RVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGS---------TTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCESLSDEMYEILSNLPE----SVAYTCVNC 1623
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Mouse
Match: Kmt2b (lysine (K)-specific methyltransferase 2B [Source:MGI Symbol;Acc:MGI:109565]) HSP 1 Score: 213.772 bits (543), Expect = 1.219e-54 Identity = 120/314 (38.22%), Postives = 172/314 (54.78%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G ++S + W +++++ + R L G G+ H VI+L EQ+ A +C +Y+F++H+ + ++PHG R + + D FL S+ P+ + L A +FR+L+ + V V S IHGRGLF +R DA E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNC+++V+ EG+KHI+I A R+I +GEELTYDY+FPIED +KLPC CG+ C+++LN Sbjct: 1713 LRFEISSDDGFSVEAESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPP-----LNPHGAARAEVYLRK----CTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKK---TSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2014 HSP 2 Score: 125.946 bits (315), Expect = 6.053e-28 Identity = 83/252 (32.94%), Postives = 125/252 (49.60%), Query Frame = 1 Query: 5113 IIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICE-KDIRHCALCA--GSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVD-MPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYE 5856 ++ S H+ A + E + + AF S+ + D R CALC G D + GRL+Y G + W HVNCA+WS +V+E DG+L NV A+ +G + C C K GAT+ C C SSC + +HF CA +F + + +C + H + + ++ D +LRR+Y+ + N G+ D I V IG++RIN +G + + SD L PIGYQ RL+WS + Sbjct: 829 VLPPSLDHVYAQWRQQESETPESGQPPGDPSAAFQSKDPAAFSHLDDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGC--------CLSSCLSNFHFMCARASY--CIFQDDKKVFC-QKHTDLLDGKEIVTPDGFDVLRRVYVDFEGI-NFKRKFLTGLEPDVINVLIGSIRINSLGTLSDLSD-CEGRLFPIGYQCSRLYWSTVD 1067 HSP 3 Score: 117.857 bits (294), Expect = 2.004e-25 Identity = 73/221 (33.03%), Postives = 107/221 (48.42%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFR--PKSKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSD-DKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG V+T+V P V C C S G +L+ C C +PFH FC+E R P+ ++ + CR C CH C G L+C +C+ +HP C+ PTR+ + +W C C C CGA T + +++WS D C RC G+ CP C R Y+ + ++C C+ VH +C GLS+++YEI P+ S + C C Sbjct: 486 GGLSVLTSVPGGPPMV-CLLCASKGLHELVFCQVCCDPFHPFCLEEAERPSPQHRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRRRRHWICSACVRCKSCGA----------TPGKNWDVEWSGDYSLCPRCTELYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPD----SVLYTCGPC 691
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Mouse
Match: Kmt2b (lysine (K)-specific methyltransferase 2B [Source:MGI Symbol;Acc:MGI:109565]) HSP 1 Score: 212.231 bits (539), Expect = 4.587e-54 Identity = 120/314 (38.22%), Postives = 172/314 (54.78%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G ++S + W +++++ + R L G G+ H VI+L EQ+ A +C +Y+F++H+ + ++PHG R + + D FL S+ P+ + L A +FR+L+ + V V S IHGRGLF +R DA E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNC+++V+ EG+KHI+I A R+I +GEELTYDY+FPIED +KLPC CG+ C+++LN Sbjct: 2412 LRFEISSDDGFSVEAESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPP-----LNPHGAARAEVYLRK----CTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKK---TSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2713 HSP 2 Score: 127.102 bits (318), Expect = 3.077e-28 Identity = 83/252 (32.94%), Postives = 125/252 (49.60%), Query Frame = 1 Query: 5113 IIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICE-KDIRHCALCA--GSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVD-MPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYE 5856 ++ S H+ A + E + + AF S+ + D R CALC G D + GRL+Y G + W HVNCA+WS +V+E DG+L NV A+ +G + C C K GAT+ C C SSC + +HF CA +F + + +C + H + + ++ D +LRR+Y+ + N G+ D I V IG++RIN +G + + SD L PIGYQ RL+WS + Sbjct: 1537 VLPPSLDHVYAQWRQQESETPESGQPPGDPSAAFQSKDPAAFSHLDDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGC--------CLSSCLSNFHFMCARASY--CIFQDDKKVFC-QKHTDLLDGKEIVTPDGFDVLRRVYVDFEGI-NFKRKFLTGLEPDVINVLIGSIRINSLGTLSDLSD-CEGRLFPIGYQCSRLYWSTVD 1775 HSP 3 Score: 117.857 bits (294), Expect = 1.849e-25 Identity = 73/221 (33.03%), Postives = 107/221 (48.42%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFR--PKSKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSD-DKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG V+T+V P V C C S G +L+ C C +PFH FC+E R P+ ++ + CR C CH C G L+C +C+ +HP C+ PTR+ + +W C C C CGA T + +++WS D C RC G+ CP C R Y+ + ++C C+ VH +C GLS+++YEI P+ S + C C Sbjct: 1194 GGLSVLTSVPGGPPMV-CLLCASKGLHELVFCQVCCDPFHPFCLEEAERPSPQHRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRRRRHWICSACVRCKSCGA----------TPGKNWDVEWSGDYSLCPRCTELYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPD----SVLYTCGPC 1399
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Mouse
Match: Kmt2b (lysine (K)-specific methyltransferase 2B [Source:MGI Symbol;Acc:MGI:109565]) HSP 1 Score: 212.231 bits (539), Expect = 4.595e-54 Identity = 120/314 (38.22%), Postives = 172/314 (54.78%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G ++S + W +++++ + R L G G+ H VI+L EQ+ A +C +Y+F++H+ + ++PHG R + + D FL S+ P+ + L A +FR+L+ + V V S IHGRGLF +R DA E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNC+++V+ EG+KHI+I A R+I +GEELTYDY+FPIED +KLPC CG+ C+++LN Sbjct: 2420 LRFEISSDDGFSVEAESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPP-----LNPHGAARAEVYLRK----CTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKK---TSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2721 HSP 2 Score: 127.102 bits (318), Expect = 3.106e-28 Identity = 83/252 (32.94%), Postives = 125/252 (49.60%), Query Frame = 1 Query: 5113 IIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICE-KDIRHCALCA--GSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVD-MPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYE 5856 ++ S H+ A + E + + AF S+ + D R CALC G D + GRL+Y G + W HVNCA+WS +V+E DG+L NV A+ +G + C C K GAT+ C C SSC + +HF CA +F + + +C + H + + ++ D +LRR+Y+ + N G+ D I V IG++RIN +G + + SD L PIGYQ RL+WS + Sbjct: 1537 VLPPSLDHVYAQWRQQESETPESGQPPGDPSAAFQSKDPAAFSHLDDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGC--------CLSSCLSNFHFMCARASY--CIFQDDKKVFC-QKHTDLLDGKEIVTPDGFDVLRRVYVDFEGI-NFKRKFLTGLEPDVINVLIGSIRINSLGTLSDLSD-CEGRLFPIGYQCSRLYWSTVD 1775 HSP 3 Score: 117.857 bits (294), Expect = 2.064e-25 Identity = 73/221 (33.03%), Postives = 107/221 (48.42%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFR--PKSKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSD-DKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG V+T+V P V C C S G +L+ C C +PFH FC+E R P+ ++ + CR C CH C G L+C +C+ +HP C+ PTR+ + +W C C C CGA T + +++WS D C RC G+ CP C R Y+ + ++C C+ VH +C GLS+++YEI P+ S + C C Sbjct: 1194 GGLSVLTSVPGGPPMV-CLLCASKGLHELVFCQVCCDPFHPFCLEEAERPSPQHRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRRRRHWICSACVRCKSCGA----------TPGKNWDVEWSGDYSLCPRCTELYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPD----SVLYTCGPC 1399
BLAST of histone lysine N methyltransferase MLL-1 vs. UniProt/SwissProt
Match: sp|P55200|KMT2A_MOUSE (Histone-lysine N-methyltransferase 2A OS=Mus musculus OX=10090 GN=Kmt2a PE=1 SV=3) HSP 1 Score: 236.498 bits (602), Expect = 1.772e-60 Identity = 120/292 (41.10%), Postives = 163/292 (55.82%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 W + ++ + R + L + +G G+ H V++L+EQ+ A C NY+F+FHK + ++PHG R + A D FL SK PP+ + ++ L R R+ + V V S IHGRGLF +R DA E++IEY G VIRSI +D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A RKIY+GEELTYDY+FPIED +KLPC CG+ C+K+LN Sbjct: 3686 AWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLAGAKHCRNYKFRFHKP------EEANEPPLNPHGSARAEVHLR----QSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR-FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 3966 HSP 2 Score: 130.954 bits (328), Expect = 1.568e-28 Identity = 77/223 (34.53%), Postives = 120/223 (53.81%), Query Frame = 1 Query: 5221 EFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 E N D R CALC GDD GRL+Y G + W HVNCALWS +V+E +DG+L NV +A+ +G++ C CQK GAT+ C C +SC + YHF C+ + VF + + YC + H + + + + RR+++ +S+ +G+ +NI + IG++ I+C+G +++ SD L PIGYQ R++WS + +Y Sbjct: 1862 ELNPPPGIDDNRQCALCLMYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGC--------CLTSCTSNYHFMCSRAK--NCVFLDDKKVYC-QRHRDLIKGEVVPENGFEVFRRVFV---DFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSD-CEDKLFPIGYQCSRVYWSTTDARKRCVY 2069 HSP 3 Score: 102.834 bits (255), Expect = 4.884e-20 Identity = 75/224 (33.48%), Postives = 104/224 (46.43%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSKEM--FVCRNCTKCHSC----DVYGSDLKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCP---ECGRAYQAGLETIECNSCNRMVHRQCCGLS--EDE-YEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +V+C+ C S G + ++C C EPFH FC+E RP ++ + CR C CH C L+C KC+ +HP C+ YP + K W C KC C CG+ T + WS D C CA+ G+ CP +C + ++C C+R VH +C LS EDE YEI PE S A+ C C Sbjct: 1417 GGLGILTSVPITP-RVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGS---------TTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCESLSGTEDEMYEILSNLPE----SVAYTCVNC 1626
BLAST of histone lysine N methyltransferase MLL-1 vs. UniProt/SwissProt
Match: sp|Q03164|KMT2A_HUMAN (Histone-lysine N-methyltransferase 2A OS=Homo sapiens OX=9606 GN=KMT2A PE=1 SV=5) HSP 1 Score: 236.113 bits (601), Expect = 2.460e-60 Identity = 120/292 (41.10%), Postives = 163/292 (55.82%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 W + ++ + R + L + +G G+ H V++L+EQ+ A C NY+F+FHK + ++PHG R + A D FL SK PP+ + ++ L R R+ + V V S IHGRGLF +R DA E++IEY G VIRSI +D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A RKIY+GEELTYDY+FPIED +KLPC CG+ C+K+LN Sbjct: 3689 AWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPE------EANEPPLNPHGSARAEVHLRKS----AFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMR-FRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKKCRKFLN 3969 HSP 2 Score: 132.109 bits (331), Expect = 7.068e-29 Identity = 77/223 (34.53%), Postives = 121/223 (54.26%), Query Frame = 1 Query: 5221 EFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 E N +D R CALC GDD GRL+Y G + W HVNCALWS +V+E +DG+L NV +A+ +G++ C CQK GAT+ C C +SC + YHF C+ + VF + + YC + H + + + + RR+++ +S+ +G+ +NI + IG++ I+C+G +++ SD L PIGYQ R++WS + +Y Sbjct: 1860 ELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGC--------CLTSCTSNYHFMCSRAK--NCVFLDDKKVYC-QRHRDLIKGEVVPENGFEVFRRVFV---DFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSD-CEDKLFPIGYQCSRVYWSTTDARKRCVY 2067 HSP 3 Score: 105.916 bits (263), Expect = 5.903e-21 Identity = 72/221 (32.58%), Postives = 103/221 (46.61%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSKEM--FVCRNCTKCHSC----DVYGSDLKCIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCP---ECGRAYQAGLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +V+C+ C S G + ++C C EPFH FC+E RP ++ + CR C CH C L+C KC+ +HP C+ YP + K W C KC C CG+ T + WS D C CA+ G+ CP +C + ++C C+R VH +C LS++ YEI PE S A+ C C Sbjct: 1418 GGLGILTSVPITP-RVVCFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGS---------TTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPE----SVAYTCVNC 1624
BLAST of histone lysine N methyltransferase MLL-1 vs. UniProt/SwissProt
Match: sp|Q9UMN6|KMT2B_HUMAN (Histone-lysine N-methyltransferase 2B OS=Homo sapiens OX=9606 GN=KMT2B PE=1 SV=1) HSP 1 Score: 213.772 bits (543), Expect = 1.141e-53 Identity = 120/314 (38.22%), Postives = 172/314 (54.78%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G ++S + W +++++ + R L G G+ H VI+L EQ+ A +C +Y+F++H+ + ++PHG R + + D FL S+ P+ + L A +FR+L+ + V V S IHGRGLF +R DA E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNC+++V+ EG+KHI+I A R+I +GEELTYDY+FPIED +KLPC CG+ C+++LN Sbjct: 2414 LRFEISSEDGFSVEAESLEGAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPP-----LNPHGAARAEVYLRK----CTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKK---TSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2715 HSP 2 Score: 124.79 bits (312), Expect = 1.164e-26 Identity = 91/298 (30.54%), Postives = 139/298 (46.64%), Query Frame = 1 Query: 4975 RAKLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGREEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAF----PSEFNSTICEKDIRHCALCA--GSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVD-MPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWS 5847 RA M+ L + ++ FD +L N ++ S H+ A + E + + AF P+ F+ +D R CALC G D + GRL+Y G + W HVNCA+WS +V+E DG+L NV A+ +G + C C K GAT+ C C SSC + +HF CA +F + + +C + H + + ++ D +LRR+Y+ + N G+ D I V IG++RI+ +G + + SD L PIGYQ RL+WS Sbjct: 1488 RAGGQMKGLLLKLLESAFGWFDAHDPKYWRRSTRLPNGVL---PNAVLPPSLDHVYAQWRQQEPETPESGQPPGDPSAAFQGKDPAAFSHL---EDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGC--------CLSSCLSNFHFMCARASY--CIFQDDKKVFC-QKHTDLLDGKEIVNPDGFDVLRRVYVDFEGI-NFKRKFLTGLEPDAINVLIGSIRIDSLGTLSDLSD-CEGRLFPIGYQCSRLYWS 1766 HSP 3 Score: 117.472 bits (293), Expect = 1.936e-24 Identity = 74/221 (33.48%), Postives = 107/221 (48.42%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFR--PKSKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSDDK-SNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG V+T+V P V C C S G +L+ C C +PFH FC+E R P+ + + CR C CH C G L+C +C+ +HP C+ PTR+ K +W C C C CGA T + +++WS D C RC + G+ CP C R Y+ + ++C C+ VH +C GLS+++YEI P+ S + C C Sbjct: 1188 GGLSVLTSVPGGPPMV-CLLCASKGLHELVFCQVCCDPFHPFCLEEAERPLPQHHDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRKRRHWICSACVRCKSCGA----------TPGKNWDVEWSGDYSLCPRCTQLYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPD----SVLYTCGPC 1393
BLAST of histone lysine N methyltransferase MLL-1 vs. UniProt/SwissProt
Match: sp|O08550|KMT2B_MOUSE (Histone-lysine N-methyltransferase 2B OS=Mus musculus OX=10090 GN=Kmt2b PE=1 SV=3) HSP 1 Score: 212.231 bits (539), Expect = 3.209e-53 Identity = 120/314 (38.22%), Postives = 172/314 (54.78%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTL--ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G ++S + W +++++ + R L G G+ H VI+L EQ+ A +C +Y+F++H+ + ++PHG R + + D FL S+ P+ + L A +FR+L+ + V V S IHGRGLF +R DA E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNC+++V+ EG+KHI+I A R+I +GEELTYDY+FPIED +KLPC CG+ C+++LN Sbjct: 2412 LRFEISSDDGFSVEAESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPP-----LNPHGAARAEVYLRK----CTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKK---TSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN 2713 HSP 2 Score: 127.102 bits (318), Expect = 2.153e-27 Identity = 83/252 (32.94%), Postives = 125/252 (49.60%), Query Frame = 1 Query: 5113 IIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICE-KDIRHCALCA--GSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVD-MPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYE 5856 ++ S H+ A + E + + AF S+ + D R CALC G D + GRL+Y G + W HVNCA+WS +V+E DG+L NV A+ +G + C C K GAT+ C C SSC + +HF CA +F + + +C + H + + ++ D +LRR+Y+ + N G+ D I V IG++RIN +G + + SD L PIGYQ RL+WS + Sbjct: 1537 VLPPSLDHVYAQWRQQESETPESGQPPGDPSAAFQSKDPAAFSHLDDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGC--------CLSSCLSNFHFMCARASY--CIFQDDKKVFC-QKHTDLLDGKEIVTPDGFDVLRRVYVDFEGI-NFKRKFLTGLEPDVINVLIGSIRINSLGTLSDLSD-CEGRLFPIGYQCSRLYWSTVD 1775 HSP 3 Score: 117.857 bits (294), Expect = 1.293e-24 Identity = 73/221 (33.03%), Postives = 107/221 (48.42%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFR--PKSKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSD-DKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG V+T+V P V C C S G +L+ C C +PFH FC+E R P+ ++ + CR C CH C G L+C +C+ +HP C+ PTR+ + +W C C C CGA T + +++WS D C RC G+ CP C R Y+ + ++C C+ VH +C GLS+++YEI P+ S + C C Sbjct: 1194 GGLSVLTSVPGGPPMV-CLLCASKGLHELVFCQVCCDPFHPFCLEEAERPSPQHRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRRRRHWICSACVRCKSCGA----------TPGKNWDVEWSGDYSLCPRCTELYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPD----SVLYTCGPC 1399
BLAST of histone lysine N methyltransferase MLL-1 vs. UniProt/SwissProt
Match: sp|Q24742|TRX_DROVI (Histone-lysine N-methyltransferase trithorax OS=Drosophila virilis OX=7244 GN=trx PE=3 SV=1) HSP 1 Score: 198.364 bits (503), Expect = 5.740e-49 Identity = 88/155 (56.77%), Postives = 115/155 (74.19%), Query Frame = 1 Query: 7633 LADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 +A ++R L+ + V V S+IHGRGL+ + +A E++IEY GE+IRS L+D RE Y G+ CYMF++D +L+VDAT +GNAARFINHSC PNCY+KVV G KHIII A R+I +GEELTYDY+FP ED+K+PC+CGS C+KYLN Sbjct: 3677 MAMKYRTLK---ETYKDYVGVFRSHIHGRGLYCTKDIEAGEMVIEYAGELIRSTLTDKRERYYDSRGIGCYMFKIDDNLVVDATMRGNAARFINHSCEPNCYSKVVDILGHKHIIIFALRRIVQGEELTYDYKFPFEDEKIPCSCGSKRCRKYLN 3828 HSP 2 Score: 99.7525 bits (247), Expect = 4.797e-19 Identity = 73/250 (29.20%), Postives = 105/250 (42.00%), Query Frame = 1 Query: 3613 EGGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCI--EYQFRPKSKE--------------------------------MFVCRNCTKCHSCDVY-GSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 + GF +I T + LC+ CGS G D LI C C EP+H +C+ EY + S E ++C CT C++C++ GS +KC KCQ +H TC+ D+ C C C C +KF G + C C + R G+ CP C + Y L+ +EC CN+ VH +C GLS+++Y + PE S F+C KC Sbjct: 1237 QTGFGLIVTETVA-QRALCFLCGSTGLDPLIFCACCCEPYHQYCVLDEYNLKHSSFEDTLMTSLLETSNNACAISAATNTALNQLTQRLNWLCPRCTVCYTCNMSSGSKVKCQKCQKNYHSTCLGTSKRLLGADRP-LICVNCLKCKSCATT--------KVSKFVGNLPM------CTACFKLRKKGNFCPICQKCYDDNDFDLKMMECGDCNQWVHSKCEGLSDEQYNLLSTLPE----SIEFICKKC 1466 HSP 3 Score: 92.4337 bits (228), Expect = 8.401e-17 Identity = 65/222 (29.28%), Postives = 97/222 (43.69%), Query Frame = 1 Query: 5248 DIRHCALC--AGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLV----DMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKI-DECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVT 5892 D R C C +G G E RL+Y G D WVH+NCA+WS +V+E DG+L NV A+ +G C C GAT+ C+ SC YH+ CA + D F ++ YC N + V + + R +Y+ + + + IG++ + +G I SD + PI + RL+WS E +V Y + T Sbjct: 1707 DTRVCLFCRKSGEGLSGEEARLLYCGHDCWVHINCAMWSAEVFEEIDGSLQNVHSAVARGRMIKCTVCGNRGATVGCNV--------KSCGEHYHYPCARTI--DCAFLTDKSMYCPAHARNALKANGSPSVTYESNFEVSRPVYV------ELERKRKKLIVPAKVQFHIGSVAVRQLGSIVPRFSDSFEA-IVPINFLCSRLYWSSKEPWKIVEYTVRTT 1911
BLAST of histone lysine N methyltransferase MLL-1 vs. TrEMBL
Match: I1ZIL1 (Histone lysine N methyltransferase MLL-1 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 995.727 bits (2573), Expect = 0.000e+0 Identity = 485/488 (99.39%), Postives = 488/488 (100.00%), Query Frame = 1 Query: 4168 SEDEYEIFKADPEAHCSSNAFLCTKCQPPDVAEETEQKKRVRLKRQCKDSGLKQYCERSVQRKTNEFIQKGEAAEEMLLEQHNVSDSAATGYNKGSMSLSQYDGHXXXXXXXKIGGNRGLMSVKDYEGLAMNSPSADMNQTSSTMFCSSESTGECDMDPLNLMDLEHQSVKVDIDVELENIEFESSRATKIGIFSRLNAPDFLSPKHLLMEALARICVKLSRYPSHSQLHKVYERFIGRIEDLTQEIFPWIDFNITMATVQMVVKKYSGRAKLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGREEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICEKDIRHCALCAGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLT 5631 +EDEYEIFKADPEAHCSSNAFLCTKCQPPDVAEETEQKKRVRLKRQCKDSGLKQYCERSVQRKTNEFIQKGEAAEEMLLEQHNVSDSAATGYNKGSMSLSQYDGHDDEDDEDKIGGNRGLMSVKDYEGLAMNSPSADMNQTSSTMFCSSESTGECDMDPLNLMDLEHQSVKVDIDVELENIEFESSRATKIGIFSRLNAPDFLSPKHLLMEALARICVKLSRYPSHSQLHKVYERFIGRIEDLTQEIFPWIDFNITMATVQMVVKKYSGRAKLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGREEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICEKDIRHCALCAGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQ++ Sbjct: 17 AEDEYEIFKADPEAHCSSNAFLCTKCQPPDVAEETEQKKRVRLKRQCKDSGLKQYCERSVQRKTNEFIQKGEAAEEMLLEQHNVSDSAATGYNKGSMSLSQYDGHDDEDDEDKIGGNRGLMSVKDYEGLAMNSPSADMNQTSSTMFCSSESTGECDMDPLNLMDLEHQSVKVDIDVELENIEFESSRATKIGIFSRLNAPDFLSPKHLLMEALARICVKLSRYPSHSQLHKVYERFIGRIEDLTQEIFPWIDFNITMATVQMVVKKYSGRAKLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGREEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICEKDIRHCALCAGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQVS 504
BLAST of histone lysine N methyltransferase MLL-1 vs. TrEMBL
Match: L0H974 (Mll1/2 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 721.85 bits (1862), Expect = 0.000e+0 Identity = 383/385 (99.48%), Postives = 383/385 (99.48%), Query Frame = 1 Query: 6514 DPPVMLRLNKIQPQRLPPSIVKQLNINQNQSKPLTFIHLGQPINRISVKNPPMNNKIFKVMKVATSSSLSPATVGVGNXXXXXXXXXXXXXXKHPSLRIVTSRPPLSSSVLRTVLTDNSHSRRVVVHQQTQPALTIGTSKSSAYHISSCGSIITPSLAQFDGEGDDSSAVTFDEFRSILAAHPAHNVGSDQENASVITMATTTTVAGVKTRKQRANHDYKFCLRFTIHGFKGSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGM 7668 DPPVMLRLNKIQPQRLPPSIVKQLNINQNQSKPLTFIHLGQPINRISVKNPPMNNKIFKVMKVATSSSLSPATVGVGNSSTSIPISPLTTATKHPSLRIVTSRPPLSSSVLRTVLTDNSHSRRVVVHQQTQPALTIGTSKSSAYHISSCGSIITPSLAQFDGEGDDSSAVTFDEFRSILAAHPAHNVGSDQENASVITMATTT VAGVKTRKQRANHDYKFCLRFTIHGFKGSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSP GCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAPLNADQLDDNPDPDEDYLRTLADQFRNLRNGM Sbjct: 3 DPPVMLRLNKIQPQRLPPSIVKQLNINQNQSKPLTFIHLGQPINRISVKNPPMNNKIFKVMKVATSSSLSPATVGVGNSSTSIPISPLTTATKHPSLRIVTSRPPLSSSVLRTVLTDNSHSRRVVVHQQTQPALTIGTSKSSAYHISSCGSIITPSLAQFDGEGDDSSAVTFDEFRSILAAHPAHNVGSDQENASVITMATTTAVAGVKTRKQRANHDYKFCLRFTIHGFKGSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPRGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAPLNADQLDDNPDPDEDYLRTLADQFRNLRNGM 387
BLAST of histone lysine N methyltransferase MLL-1 vs. TrEMBL
Match: A0A2T7P2D2 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_12741 PE=4 SV=1) HSP 1 Score: 246.514 bits (628), Expect = 5.962e-66 Identity = 125/293 (42.66%), Postives = 176/293 (60.07%), Query Frame = 1 Query: 7222 KSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSK-SNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 + W + +R+ R + + + +G FG+ H V+YLVEQ+ A C +Y F+ H+ ++ L +++P GC R +T KP I +FL+S+ +P K H+ + + +A +FR L+ + + V V S IHGRGLF +R DA E++IEY GE+IRS+L+D RE Y+ G+ CYMFR+D +VDAT G+AARFINHSC PNCY+KV++ +G KHI+I A R I KGEELTYDY+FPIED K+PCTCGS C+KYLN Sbjct: 285 EEAWRQVTERVQDARAASRMKQLSYAGLNGVQMFGIGHEAVVYLVEQLQGARHCRHYTFR-HQQYEPPEEDEEL--IINPSGCARCEPFTTRKPYDI----FSFLNSRYRRHPSKVHSNREEEMEPKSSRRATSMELPMAMRFRKLQ---EHAKEAVGVYRSKIHGRGLFCKRNIDAGEMVIEYAGEIIRSLLTDKREKYYESKGIGCYMFRIDDCEVVDATMHGSAARFINHSCEPNCYSKVIQVDGRKHIVIFAMRPIKKGEELTYDYKFPIEDVKIPCTCGSKRCRKYLN 567
BLAST of histone lysine N methyltransferase MLL-1 vs. TrEMBL
Match: A0A1E1XAP5 (Putative histone H3 lys4 methyltransferase complex subunit set1 (Fragment) OS=Amblyomma aureolatum OX=187763 PE=2 SV=1) HSP 1 Score: 249.21 bits (635), Expect = 2.680e-65 Identity = 128/291 (43.99%), Postives = 172/291 (59.11%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLH-SKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 W + +++ R + + DG+A GL H+ V+YL EQ+ A C NY F++HK TKL +P GC R + +++ H LA H S +Y P N + L + +A +FR+L+N + V V SNIHGRGL+ RR D E+IIEY GEVIR++L+D RE Y+ G+ CYMFR+D +VDAT GNAARFINHSC PNCY+KV+ + +KHI+I A R I KGEELTYDY+FPIED K+PC+CGS C+K+LN Sbjct: 453 AWRYLFEKLQDARAGANMPPLTNDDVDGFAMMGLTHKAVVYLTEQLRGADNCENYNFQYHKRNSTKLPE-------NPSGCARLEGF-RSRGHHDMFKFLASAHRSPPSYDPSNDNGDEVEVLHKSSRRLTSLDLPMAMRFRHLKN---TAKEAVGVYRSNIHGRGLYCRRNIDGGEMIIEYAGEVIRAVLTDKREKYYESKGIGCYMFRIDDHEVVDATMHGNAARFINHSCEPNCYSKVITVDNKKHIVIFALRSILKGEELTYDYKFPIEDVKIPCSCGSRRCRKFLN 732
BLAST of histone lysine N methyltransferase MLL-1 vs. TrEMBL
Match: A0A2R5LN23 (Putative histone-lysine n-methyltransferase mll isoform x17 OS=Ornithodoros turicata OX=34597 PE=4 SV=1) HSP 1 Score: 254.218 bits (648), Expect = 6.690e-65 Identity = 129/296 (43.58%), Postives = 172/296 (58.11%), Query Frame = 1 Query: 7228 GWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRT------LADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 W + +++ R + L V + DG+A GL H V+YL+EQ+ C NY FKFHK KL GC R + DH D FL S+ PP+ ++ ++ + R +A +FR+L+ + V V S+IHGRGL+ RR DA E+IIEY GEVIR+ L+D RE Y+ G+ CYMFR+D +VDAT GNAARFINHSC PNCY+KV+ + +KHI+I AQR+I KGEELTYDY+FPIED K+PC+CGS C+K+LN Sbjct: 784 AWRYVFEKLQDSRAAANLQPLTVDDVDGYAMIGLVHNTVVYLIEQLPGTDNCINYTFKFHKKECVKLPENA-------SGCARLEWYRGRGEDH---DMFKFLASRHRLPPQYDPLASSQTTEEVEVVHKSSRRVTSLDLPMAMRFRHLKT---TAKEAVGVYRSSIHGRGLYCRRNIDAGEMIIEYAGEVIRAALTDKREKYYESKGIGCYMFRIDDTDVVDATMHGNAARFINHSCDPNCYSKVITVDNKKHIVIFAQRRILKGEELTYDYKFPIEDVKIPCSCGSRRCRKFLN 1066
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Cavefish
Match: kmt2bb (lysine (K)-specific methyltransferase 2Bb [Source:ZFIN;Acc:ZDB-GENE-080521-1]) HSP 1 Score: 219.55 bits (558), Expect = 2.676e-56 Identity = 126/314 (40.13%), Postives = 173/314 (55.10%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKN--HAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G + S + W ++ + + R + L + +G GL H V+YLVEQ+ A C+ + F+FHK +Q ++P GC R + + D FL S+ P + D L + +A +FR+L + V V S IHGRGLF +R +A E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ EG+KHI+I A RKIY+GEELTYDY+FPIED +KL C CG+ C+++LN Sbjct: 3696 LRFKITSDDGFSVEADSIEVAWRAVLDGVQEARAAAKLRQLSFTGMNGARMMGLLHDAVVYLVEQLQGASSCHRHPFRFHKQA-----SQEEDLPINPSGCARSEVYLRKS----TFDMFNFLASQHRQLPDTDLYDEEEDDVLLKSSRRATSLELPMAMRFRHLER---TSKEAVGVYRSAIHGRGLFCKRNIEAGEMVIEYSGIVIRSVLTDKREKYYDGKGIGCYMFRIDDFDVVDATMHGNAARFINHSCEPNCYSRVINVEGQKHIVIFALRKIYRGEELTYDYKFPIEDASNKLGCNCGARRCRRFLN 3997 HSP 2 Score: 116.316 bits (290), Expect = 4.539e-25 Identity = 75/227 (33.04%), Postives = 108/227 (47.58%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPK--SKEMFVCRNCTKCHSCDVYGSDLK----CIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKCQPPDVAE 4266 GG ++T+V P V C C S G ++++C C EPFH FC++ RP+ +KE + CR C C C LK C +CQ +HP C+ P + K +W C C C CG T S + +W +D C C R G+ C C + Y+ + ++C+SCN VH +C GL++D YEI + PE+ S C + QP V E Sbjct: 1716 GGMSILTSVPLMPQSV-CLLCASRGQHEMLYCQVCCEPFHPFCLDPSERPQEENKENWCCRRCKFCRVCGRKNKPLKPLLECERCQNCYHPACLGPNYPKPNRRKRSWVCMTCIRCKSCGV----------TPGKSWDTEWDQDKGLCPDCTRLYEQGNYCTMCFKCYEDNDYESQMMQCSSCNHWVHAKCEGLTDDLYEILSSLPESVVYS-CQPCIEAQPAGVQE 1930 HSP 3 Score: 116.316 bits (290), Expect = 5.019e-25 Identity = 68/214 (31.78%), Postives = 118/214 (55.14%), Query Frame = 1 Query: 5218 SEFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWS 5847 S+ ++ + D R C LC GD + GRL+Y G + W HVNC++WS +V+E ++G L++V A+ +G C C + GAT+ C C +SC + YHF CA + + VF + +T +C + H + ++ +T +LRR+Y+ +S+ G+ ++I + IG+L ++ +GK++E S + L P+GY+ R +WS Sbjct: 2152 SDLDTGWSKDDERQCVLCQKYGDAKSADAGRLLYLGQNEWAHVNCSMWSAEVFEEDNGCLMHVHSAVARGRLMRCERCNQTGATVGC--------CLTSCQSNYHFMCARSR--NCVFQDDKTVFCYK-HRDLISGQIITGQGFEVLRRVYV---DFEGISLRRKFLTGLEPESINMKIGSLLVSKLGKLNELSAS-QGKLVPVGYECSRWYWS 2350
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Cavefish
Match: ENSAMXT00000056389.1 (pep primary_assembly:Astyanax_mexicanus-2.0:2:23791729:23793332:-1 gene:ENSAMXG00000030713.1 transcript:ENSAMXT00000056389.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 161.384 bits (407), Expect = 1.795e-45 Identity = 73/116 (62.93%), Postives = 92/116 (79.31%), Query Frame = 1 Query: 7756 IIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 ++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++VV +G+KHI+I A RKIY+GEELTYDY+FPIE+ +KLPC CG+ C+K+LN Sbjct: 1 MVIEYSGNVIRSVLTDKREKYYDGKGIGCYMFRIDDYEVVDATMHGNAARFINHSCEPNCYSRVVNIDGQKHIVIFAMRKIYRGEELTYDYKFPIEEPGNKLPCNCGAKKCRKFLN 116
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Cavefish
Match: ENSAMXT00000040628.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000250.1:95310:97223:1 gene:ENSAMXG00000030555.1 transcript:ENSAMXT00000040628.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 155.606 bits (392), Expect = 1.585e-43 Identity = 71/116 (61.21%), Postives = 89/116 (76.72%), Query Frame = 1 Query: 7756 IIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 ++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ EG KHI+I A RKIY+GEELTYDY+FPIED +KL C C + C+++LN Sbjct: 1 MVIEYAGNVIRSVLTDKREKYYDSKGIGCYMFRIDDFDVVDATMHGNAARFINHSCEPNCYSRVINVEGRKHIVIFALRKIYRGEELTYDYKFPIEDASNKLHCNCSARRCRRFLN 116
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Cavefish
Match: setd1ba (SET domain containing 1B, histone lysine methyltransferase [Source:NCBI gene;Acc:103032383]) HSP 1 Score: 173.326 bits (438), Expect = 1.891e-42 Identity = 77/147 (52.38%), Postives = 105/147 (71.43%), Query Frame = 1 Query: 7660 NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 N + R K +R C S+IH GLFA A E++IEYVG+ IR +++D+RE Y+ G+ YMFR+D D I+DAT GN ARFINHSC+PNCYAKV+ E +K I+I +++ I EE+TYDY+FPIED+K+PC CG+ +C+ LN Sbjct: 1703 NQLKFRKKKIRFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEEEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSRQPINVNEEITYDYKFPIEDEKIPCLCGAENCRGTLN 1849
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Cavefish
Match: ENSAMXT00000041567.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001314.1:1300751:1307385:-1 gene:ENSAMXG00000036494.1 transcript:ENSAMXT00000041567.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 158.688 bits (400), Expect = 1.222e-41 Identity = 98/321 (30.53%), Postives = 164/321 (51.09%), Query Frame = 1 Query: 7171 KFCLRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLME-YPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKT-----VRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDD--KLPCTCGSFSCKKYLN 8097 +F +R G++ SPK W +++ + R G+++ +PV G FGL V +VE + C+ Y F++ + + +L ++P GC R +P A H K + + + + Q + + + + QF + ++ R K V + S I G GL+A R + ++IEY+G +IR+ +++ +E Y+ YMFR+D + ++DAT G AR+INHSC PNC A+VV FE + I+I + R+I +GEEL YDY+F +EDD K+PC CG+ +C+K++N Sbjct: 45 EFSIRVIEQGYEDLLLTGSSPKGVWDKVLEPVADRRNETGILKLFPVYL-KGEDLFGLTVPAVTRIVESLPGVEACSRYTFRYGRNPLMEL-----PLAINPSGCAR-------------SEPKALTHVKRPHTLTSGSTIKTLQTNGGSPAELTGV-PYSKQFVHSKSSQYRRMKAEWKSNVYLARSRIQGLGLYAARDIEKDTLVIEYIGTIIRNEVANRKEKMYESQNRGVYMFRIDSEHVIDATITGGPARYINHSCAPNCIAEVVTFEKDHKIMITSNRRIQRGEELCYDYKFDLEDDQHKIPCHCGAVNCRKWMN 345
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Sea Lamprey
Match: setd1a (SET domain containing 1A, histone lysine methyltransferase [Source:ZFIN;Acc:ZDB-GENE-080521-4]) HSP 1 Score: 162.54 bits (410), Expect = 8.505e-40 Identity = 74/147 (50.34%), Postives = 102/147 (69.39%), Query Frame = 1 Query: 7660 NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 N + R K +R S IH GLFA A E++IEYVG+ IR +++D+RE Y+ G+ Y+FR+D D I+DAT GN ARFINHSC+PNCYAKV+ E +K I+I +++ I EE+TYDY+FPIE++K+PC CG+ C+ LN Sbjct: 1708 NQLKFRKKKLRFTKSRIHEWGLFALEPIAAEEMVIEYVGQGIRQLVADMREKRYEVEGIGSSYLFRVDHDTIIDATKVGNLARFINHSCNPNCYAKVITVESQKRIVIYSKQAINVNEEITYDYKFPIEENKIPCLCGAEHCRGTLN 1854
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010827.1 (pep scaffold:Pmarinus_7.0:GL487806:1944:5585:-1 gene:ENSPMAG00000009809.1 transcript:ENSPMAT00000010827.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 142.51 bits (358), Expect = 2.467e-39 Identity = 66/132 (50.00%), Postives = 94/132 (71.21%), Query Frame = 1 Query: 7711 HGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKH-IIIIAQRKIYKGEELTYDYRFPIEDD--KLPCTCGSFSCKKYLN 8097 G GL+A R + H ++IEY+G +IR+ +++ RE Y+ YMFR+D D ++DAT G AR+INHSC PNC A+VV F+ E+ IIII+ R++ KGEELTYDY+F EDD K+PC CG+ +C+K++N Sbjct: 5 QGLGLYAARDIEKHTMVIEYIGTIIRNEVANRREALYKAQNRGVYMFRIDGDHVIDATLTGGPARYINHSCSPNCVAEVVNFDKERSKIIIISSRRLQKGEELTYDYKFDFEDDQHKIPCHCGAPNCRKWMN 136
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002322.1 (pep scaffold:Pmarinus_7.0:GL477101:2485:64197:1 gene:ENSPMAG00000002099.1 transcript:ENSPMAT00000002322.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 160.614 bits (405), Expect = 4.480e-39 Identity = 101/320 (31.56%), Postives = 163/320 (50.94%), Query Frame = 1 Query: 7171 KFCLRFTIHGFK----GSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKT-----VRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDD--KLPCTCGSFSCKKYLN 8097 +F +R G + + +P+ W I++ + ++RK ++ G FGL + V+ + E + C NY F++ + + +L V+P GC R T+P +S++ + +++ + + QF ++ R KT V + S I G GL+A R + H ++IEY+GE+IR+ +++ E Y+ T YMFRLD + ++DAT G AR+INHSC PNC A++V F+ E III + R+I KGEELTYDY F EDD K+PC CG+ +C+K++N Sbjct: 3625 QFTVRIVEQGHEDLVHAASTPQGVWDKILEPVVRLRKGAEMLRLFPDYMRGEEMFGLTVQAVLRITESLPGVECCQNYMFRYGRHPLMEL-----PLAVNPSGCAR------TEP-----------RLRSHFKRPHTLNSSSNSKSFQSTMSGELSAPYSKQFVYSKSSQYRRMKTEWKINVYLARSRIQGLGLYASRDIEKHTMVIEYIGEIIRNEVANRHEKLYESTNRGVYMFRLDSEHVIDATITGGPARYINHSCAPNCVAELVTFDRENKIIISSCRRIQKGEELTYDYLFDFEDDQNKIPCHCGAINCRKWMN 3922 HSP 2 Score: 127.872 bits (320), Expect = 2.901e-29 Identity = 80/223 (35.87%), Postives = 114/223 (51.12%), Query Frame = 1 Query: 5248 DIRHCALCAGSGDDRLEG--RLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKI---DECSDYL--RVYLCPIGYQARRLFWSMYELDSLVMYYMNVTK 5895 D+R C+ C GD +G RL+ LD+WVH+NCALWS +VYE + GAL+NV+ A R+G C AC + GAT C+ P CPNVYHFACA M +F + +T C T +L +LRR+Y+ + + ++ G +G+L + +G+I S Y R L PIGYQA RL+WS + Y +V++ Sbjct: 3410 DMRSCSFCHLQGDGATDGPARLLNLDLDIWVHLNCALWSSEVYETQAGALINVEGARRRGLGTKCGACLRMGATTSCNRP--------RCPNVYHFACALRM--RCMFFKDKTVLCPAHRPRSSTGQELGC--FAVLRRVYVQRDEVRQLASLVRRGPMGGG-TFRVGSLLFHALGQILPGQASSPYFHSRTALYPIGYQATRLYWSTRYTNKRCRYLCSVSE 3619
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002229.1 (pep scaffold:Pmarinus_7.0:GL477110:4214:18323:-1 gene:ENSPMAG00000002027.1 transcript:ENSPMAT00000002229.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 105.145 bits (261), Expect = 4.586e-23 Identity = 64/197 (32.49%), Postives = 101/197 (51.27%), Query Frame = 1 Query: 5299 GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNV 5889 GRL+ G D W H NCA+WS +V+E +DG+L NV A+ +G++ C C + GAT+ C P +C +HF CA VF + + YC + H + + + +LRR+++ + + G+ D I + IG+L I C+G +++ S Y L PIGYQ R++WS + L +Y V Sbjct: 350 GRLLGIGQDEWTHSNCAVWSAEVFEDDDGSLKNVHAAVWRGKQLRCEHCGRMGATVGCCLP--------ACQANFHFMCA--RARSCVFQDDKKLYC-QRHKDLIRGEVVAEDGFEVLRRVFVDFEGIG-LRRKFLSGLEPDKIQMMIGSLTIECLGVLNDLSLY-EGKLFPIGYQCTRVYWSTADARRLCVYTCKV 533
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004922.1 (pep scaffold:Pmarinus_7.0:GL479351:23010:32607:-1 gene:ENSPMAG00000004401.1 transcript:ENSPMAT00000004922.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 95.9005 bits (237), Expect = 7.031e-20 Identity = 50/115 (43.48%), Postives = 67/115 (58.26%), Query Frame = 1 Query: 7702 SNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED 8046 S++ G G+F + +E I EY GE+I +D R Y + ++F L+ D +VDAT KGN RF NHS PNCYAKV+ G+ I I A+R I GEEL +DYR+ D Sbjct: 656 SDVAGWGIFIKVPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCS-FLFNLNNDFVVDATRKGNKIRFANHSVSPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQAD 769
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Yeast
Match: SET1 (Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-Sen1p pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain [Source:SGD;Acc:S000001161]) HSP 1 Score: 145.976 bits (367), Expect = 3.373e-35 Identity = 71/150 (47.33%), Postives = 97/150 (64.67%), Query Frame = 1 Query: 7660 NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDD---KLPCTCGSFSCKKYLN 8097 N ++ R K V S IH GL+A A E+IIEYVGE IR ++++RE Y + G+ Y+FR+D++ ++DAT KG ARFINH C PNC AK+++ G + I+I A R I EELTYDY+F E D +LPC CG+ +CK +LN Sbjct: 931 NQLNKRKKPVMFARSAIHNWGLYALDSIAAKEMIIEYVGERIRQPVAEMREKRYLKNGIGSSYLFRVDENTVIDATKKGGIARFINHCCDPNCTAKIIKVGGRRRIVIYALRDIAASEELTYDYKFEREKDDEERLPCLCGAPNCKGFLN 1080
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Yeast
Match: SET2 (Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36 (H3K36), which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain(CTD) of Rpo21p; H3K36me3 (trimethylation) requires Spt6p, proline 38 on H3, CTD of Rpo21p, Ctk1p, and C-terminal SRI domain of Ste2p; relocalizes to the cytosol in response to hypoxia [Source:SGD;Acc:S000003704]) HSP 1 Score: 78.5666 bits (192), Expect = 1.011e-14 Identity = 51/131 (38.93%), Postives = 69/131 (52.67%), Query Frame = 1 Query: 7714 GRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEY-QRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDY---RFPIEDDKLPCTCGSFSCKKYL 8094 G G+ A + +A++ I EY GEVI + R +Y QR Y L +DAT KG+ ARF NHSC PN Y + + + I AQRKI KGEE+T+DY R+ + K C C +C +L Sbjct: 131 GYGVRAEQDIEANQFIYEYKGEVIEEMEFRDRLIDYDQRHFKHFYFMMLQNGEFIDATIKGSLARFCNHSCSPNAYVNKWVVKDKLRMGIFAQRKILKGEEITFDYNVDRYGAQAQK--CYCEEPNCIGFL 259
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Nematostella
Match: EDO30858 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZK6]) HSP 1 Score: 206.453 bits (524), Expect = 6.298e-59 Identity = 126/319 (39.50%), Postives = 171/319 (53.61%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDH--IARDPLAFLHSKSNYPPK---NHAXXXXXXXXXXXXXXXXXXRTL----ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 +RF I G + S K W +I + R S L + P G+ V Y++EQ+ A NY F+++ T + L +P GC R T+P H + D AFL S+ PP+ N+ L A + TL A ++R+L+ + T+ V S IHGRGL+ R A E++IEY G +IRS L+D RE Y+ G+ CYMFR+D +VDAT GNAARFINHSC PNCY++VV +G K I+I A + I +GEELTYDY+FP+ED+KLPC C S C+KYLN Sbjct: 4 IRFVITNDDGLRIEADSHKVAWRMIFDLVRDSRSSHLLKDLPFIGVSDRCMIGVTDEPVTYILEQLADAHLLRNYRFQYNPPFGTNGEDG-LELKENPTGCCR------TEPHHRRLMYDMFAFLASEYRTPPQLDDNYDELEAAEQAWGNMTTIKRPTTLDLPMAMRYRHLKQN-NYNKGTIAVFRSGIHGRGLYCTRHIAAGEMVIEYSGMLIRSTLTDKREAYYESKGIGCYMFRIDGTYVVDATTSGNAARFINHSCEPNCYSRVVTIDGNKKILIFASKSISRGEELTYDYKFPLEDEKLPCHCKSKRCRKYLN 314
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Nematostella
Match: EDO30857 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZK5]) HSP 1 Score: 199.519 bits (506), Expect = 7.425e-57 Identity = 119/296 (40.20%), Postives = 162/296 (54.73%), Query Frame = 1 Query: 7237 LIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDH--IARDPLAFLHSKSNYPPK---NHAXXXXXXXXXXXXXXXXXXRTL----ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 +I + R S L + P G+ V Y++EQ+ A NY F+++ T + L +P GC R T+P H + D AFL S+ PP+ N+ L A + TL A ++R+L+ + T+ V S IHGRGL+ R A E++IEY G +IRS L+D RE Y+ G+ CYMFR+D +VDAT GNAARFINHSC PNCY++VV +G K I+I A + I +GEELTYDY+FP+ED+KLPC C S C+KYLN Sbjct: 1 MIFDLVRDSRSSHLLKDLPFIGVSDRCMIGVTDEPVTYILEQLADAHLLRNYRFQYNPPFGTNGEDG-LELKENPTGCCR------TEPHHRRLMYDMFAFLASEYRTPPQLDDNYDELEAAEQAWGNMTTIKRPTTLDLPMAMRYRHLKQN-NYNKGTIAVFRSGIHGRGLYCTRHIAAGEMVIEYSGMLIRSTLTDKREAYYESKGIGCYMFRIDGTYVVDATTSGNAARFINHSCEPNCYSRVVTIDGNKKILIFASKSISRGEELTYDYKFPLEDEKLPCHCKSKRCRKYLN 288
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Nematostella
Match: EDO31259 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYF5]) HSP 1 Score: 196.823 bits (499), Expect = 1.257e-55 Identity = 124/319 (38.87%), Postives = 168/319 (52.66%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHG-CVR-FNQWTKTKPDHIARDPLAFLHSKSNYPPK---NHAXXXXXXXXXXXXXXXXXXRTL----ADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 +RF I G + S K W +I + R S L + P G+ V Y++EQ+ A NY F+++ T D ++P CV F + K D AFL S+ PP+ N+ L A + TL A ++R+L+ + T+ V S IHGRGL+ R A E++IEY G +IRS L+D RE Y+ G+ CYMFR+D +VDAT GNAARFINHSC PNCY++VV +G K I+I A + I +GEELTYDY+FP+ED+KLPC C S C+KYLN Sbjct: 4 IRFVITNDDGLRIEADSHKVAWRMIFDLVRDSRSSHLLKDLPFIGVSDRCMIGVTDEPVTYILEQLADAHLLRNYRFQYNPPFGTNGE-----DGLTPETYCVNAFCGYRKK-----MYDMFAFLASEYRTPPQLDDNYDELEAAEQAWGNMTTIKRPTTLDLPMAMRYRHLKQN-NYNKGTIAVFRSGIHGRGLYCTRHIAAGEMVIEYSGMLIRSTLTDKREAYYESKGIGCYMFRIDGTYVVDATTSGNAARFINHSCEPNCYSRVVTIDGNKKILIFASKSISRGEELTYDYKFPLEDEKLPCHCKSKRCRKYLN 311
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Nematostella
Match: EDO44546 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVC2]) HSP 1 Score: 159.458 bits (402), Expect = 5.733e-44 Identity = 77/147 (52.38%), Postives = 99/147 (67.35%), Query Frame = 1 Query: 7660 NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 N + R K ++ S+IH GLFA A E++IEYVGEVIR ++D RE Y+ G+ YMFRLD+ I+DAT GN ARFINH C PNCYAKV+ E K I+I ++R I EE+TYDY+FPIED+K+PC CG+ C+ LN Sbjct: 67 NKLRVRKKQLKFAKSSIHDWGLFALEPIAADEMVIEYVGEVIRQAIADYRERCYEERGIGSSYMFRLDETTIIDATTMGNFARFINHCCDPNCYAKVIAVENMKKIVIYSKRDIQVDEEITYDYKFPIEDEKIPCLCGAPQCRGTLN 213
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Nematostella
Match: EDO37589 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFA7]) HSP 1 Score: 152.91 bits (385), Expect = 5.711e-39 Identity = 107/315 (33.97%), Postives = 164/315 (52.06%), Query Frame = 1 Query: 7174 FCLRFTIHG-----FKGSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDD--KLPCTCGSFSCKKYLN 8097 F LR G FKG KSP+ W +++ I ++RK L+ G FGL + V+ ++E M Y ++ + + ++ ++P GC R KT H + S S + + + + ++ + A Q+R L+ + V + SNI G GLFA R + ++IEY+G +IR+ +++ +E+ Y+ YMFR+D D ++DAT G AR+INHSC PNC A+VV FE E+ IIII+ RKI KGEELTYDY+F EDD K+ C CG+ +C+K++N Sbjct: 163 FTLRVNEQGHEDTVFKG-KSPRDVWKQVLEPIHKLRKEAVLVNLWPAYITGEDLFGLTEQFVLRIIESMPGVDYMQGYNMRYGPSSIMEM-----PLAINPTGCARAEALIKT---HFR--STRSVSSISTAGSNAAGNSSREAEESTSLYMKQFVYSKASQYRKLKTEW---RQNVFLGRSNIQGLGLFANRDMEPGCMVIEYIGSIIRNEVANKKESIYESQNRGIYMFRIDSDSVIDATIAGGPARYINHSCMPNCVAEVVTFEKEQKIIIISSRKIEKGEELTYDYKFDFEDDEHKISCLCGAPNCRKWMN 463
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Medaka
Match: KMT2A (lysine methyltransferase 2A [Source:NCBI gene;Acc:101171020]) HSP 1 Score: 219.55 bits (558), Expect = 2.788e-56 Identity = 119/302 (39.40%), Postives = 168/302 (55.63%), Query Frame = 1 Query: 7210 SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIAR---DPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXR-TLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 S+S + W + ++ + R L + +G G+ H V++L+EQ+ + C +Y F+FHK ++ ++PHG R H R D FL SK PP+ + + LA +F+ L+ +TV V S IHGRGLF ++ +A E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A R+I GEELTYDY+FPIED +KLPC CG+ C+K+LN Sbjct: 3881 SESIEDAWKCLTDKVKEARSHARLSDLSFDGVNGLRMLGIVHEAVVFLLEQLCGSKHCRSYSFRFHKPEESE------DPPLNPHGSARAEI-------HHRRSVFDMFNFLASKHRQPPEYRPQEEEEDEGQLRIIRRASMELPLAVRFKQLKA---MSKETVGVYRSPIHGRGLFCKKTIEAGEMVIEYSGNVIRSVLTDKREKYYDAKGIGCYMFRIDDYEVVDATVHGNAARFINHSCEPNCYSRVLTVDGQKHIVIFASRRICCGEELTYDYKFPIEDASNKLPCNCGTKKCRKFLN 4166 HSP 2 Score: 129.028 bits (323), Expect = 6.310e-29 Identity = 77/215 (35.81%), Postives = 115/215 (53.49%), Query Frame = 1 Query: 5248 DIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLT---LVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 D R C C GD+++ GRL+Y G + W HVNCALWS +V+E +D +L NV +A+ +G+K C CQK GAT+ C C +SC YHF CA F E + YC + H + V+ ++T LVDM +G N G+ +++ + IG+++I+C+G + E SD R L P+GYQ R++WS + +Y Sbjct: 2048 DNRKCVFCFKYGDEKINECGRLLYIGQNEWTHVNCALWSAEVFEDDDASLKNVHMAVLRGKKMCCERCQKTGATVSC--------CFTSCTRNYHFMCARQC--QCTFLEDKKIYCPK-HRDVVSGFEVTRRILVDM---------EGI--NFKRKFLAGLEPESVHMMIGSMKIDCLGILTELSDCKR-KLFPLGYQCSRVYWSTLDARKRCVY 2239 HSP 3 Score: 97.0561 bits (240), Expect = 3.336e-19 Identity = 67/224 (29.91%), Postives = 101/224 (45.09%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSK--EMFVCRNCTKCHSCDVYGSDLK-----CIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQ-----AGLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +VLC+ C S G+ + ++C C EPFH FC+ RP + E + CR C C +C K C KC+ +HP C+ YP + K W C KC C CGA S + WS D C CA+ G+ CP C ++Y + + + + + + C LS++ +E+ PE + A+ C KC Sbjct: 1589 GGLSLLTSVPITP-RVLCFLCASSGNVEFVYCRVCCEPFHLFCLGESERPLQEQFENWCCRLCRFCQACGRQHQKAKQQLVECDKCRNSYHPECLGPNYPTKPTKKKRIWICTKCVRCKSCGATKPGK---------SWDAQWSHDFSMCHDCAKLFAKGNFCPLCDKSYSDDYYDSKMMEFYSITWHMVANLSCYCLSDEMFELLSKLPE----NIAYTCMKC 1798
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Medaka
Match: KMT2A (lysine methyltransferase 2A [Source:NCBI gene;Acc:101171020]) HSP 1 Score: 219.55 bits (558), Expect = 3.087e-56 Identity = 119/302 (39.40%), Postives = 168/302 (55.63%), Query Frame = 1 Query: 7210 SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIAR---DPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXR-TLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 S+S + W + ++ + R L + +G G+ H V++L+EQ+ + C +Y F+FHK ++ ++PHG R H R D FL SK PP+ + + LA +F+ L+ +TV V S IHGRGLF ++ +A E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ +G+KHI+I A R+I GEELTYDY+FPIED +KLPC CG+ C+K+LN Sbjct: 4254 SESIEDAWKCLTDKVKEARSHARLSDLSFDGVNGLRMLGIVHEAVVFLLEQLCGSKHCRSYSFRFHKPEESE------DPPLNPHGSARAEI-------HHRRSVFDMFNFLASKHRQPPEYRPQEEEEDEGQLRIIRRASMELPLAVRFKQLKA---MSKETVGVYRSPIHGRGLFCKKTIEAGEMVIEYSGNVIRSVLTDKREKYYDAKGIGCYMFRIDDYEVVDATVHGNAARFINHSCEPNCYSRVLTVDGQKHIVIFASRRICCGEELTYDYKFPIEDASNKLPCNCGTKKCRKFLN 4539 HSP 2 Score: 128.257 bits (321), Expect = 1.315e-28 Identity = 74/212 (34.91%), Postives = 112/212 (52.83%), Query Frame = 1 Query: 5248 DIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 D R C C GD+++ GRL+Y G + W HVNCALWS +V+E +D +L NV +A+ +G+K C CQK GAT+ C C +SC YHF CA F E + YC + D +V + + RRI + + N G+ +++ + IG+++I+C+G + E SD R L P+GYQ R++WS + +Y Sbjct: 2118 DNRKCVFCFKYGDEKINECGRLLYIGQNEWTHVNCALWSAEVFEDDDASLKNVHMAVLRGKKMCCERCQKTGATVSC--------CFTSCTRNYHFMCARQC--QCTFLEDKKIYCPKHRDVIRGEV---VSGFEVTRRILVDMEGI-NFKRKFLAGLEPESVHMMIGSMKIDCLGILTELSDCKR-KLFPLGYQCSRVYWSTLDARKRCVY 2314 HSP 3 Score: 110.923 bits (276), Expect = 1.964e-23 Identity = 70/222 (31.53%), Postives = 104/222 (46.85%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRPKSK--EMFVCRNCTKCHSCDVYGSDLK-----CIKCQLGFHPTCV-DKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAGL---ETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKC 4245 GG ++T+V P +VLC+ C S G+ + ++C C EPFH FC+ RP + E + CR C C +C K C KC+ +HP C+ YP + K W C KC C CGA S + WS D C CA+ G+ CP C ++Y + +EC C + VH +C ++++ +E+ PE + A+ C KC Sbjct: 1661 GGLSLLTSVPITP-RVLCFLCASSGNVEFVYCRVCCEPFHLFCLGESERPLQEQFENWCCRLCRFCQACGRQHQKAKQQLVECDKCRNSYHPECLGPNYPTKPTKKKRIWICTKCVRCKSCGATKPGK---------SWDAQWSHDFSMCHDCAKLFAKGNFCPLCDKSYSDDYYDSKMMECARCKQWVHAKCENITDEMFELLSKLPE----NIAYTCMKC 1868
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Medaka
Match: kmt2ba (histone-lysine N-methyltransferase 2B [Source:NCBI gene;Acc:101157226]) HSP 1 Score: 213.001 bits (541), Expect = 2.358e-54 Identity = 129/329 (39.21%), Postives = 180/329 (54.71%), Query Frame = 1 Query: 7138 KTRKQRANHDYKFCLRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRT---LADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDD--KLPCTCGSFSCKKYLN 8097 K RK N + LRF I G + S + W ++ + + R + L + P+ G G+ H VI+L+EQ+ A C + F+FH R L + ++ GC R +T+ D FL S+ P P + D+ + T +A +FR+L + V V S IHGRGLF +R +A E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT +GNAARFINHSC PNCY++V+ +G KHI+I A RKIY+GEELTYDY+FPIED+ KL C CG+ C+++LN Sbjct: 2454 KHRKTYMNQPH---LRFEITSEDGFSVKANSIEVAWRAVIDGVFEARAAFHLKQLPLGVMSGPRVLGVVHDAVIFLLEQLQGAADCKRHRFRFH--RCDALEEE---PPLNASGCARAEVYTR----KATFDMFNFLASQHRQLPDLVGPFDEDEDEFPLKASRRATSTELPMAMRFRHLEK---TSKEAVGVYRSLIHGRGLFCKRNIEAGEMVIEYAGTVIRSVLTDKREKFYDGKGIGCYMFRIDDFDVVDATMQGNAARFINHSCEPNCYSRVINVDGRKHIVIFALRKIYRGEELTYDYKFPIEDEDNKLHCNCGTRRCRRFLN 2767 HSP 2 Score: 117.472 bits (293), Expect = 2.243e-25 Identity = 97/330 (29.39%), Postives = 149/330 (45.15%), Query Frame = 1 Query: 4981 KLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGR-EEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVA------------FPSEFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVTKELNNKANGDD 5925 KL QA A V+ + R F F + + S F G + ++ S++H A + +E Y A + P + + +D+R C LC GD GRL+Y G + W HVNC LWS +VYE ++GAL+ V A+ +G C C + GAT+ C C ++C + +HF CA VF R YC D T V ++ + RR+Y+ + N+ G+ + I +TIG+L+I +G + E S R+ L P+GYQ RL+WS + Y VT E++ G++ Sbjct: 1252 KLTTQARAHYVQ-VMKRVFSWFPACYFKKWSSFSEEFPTGMLPDAVLPPSQEHSYA--QWLERTYQAKEPRAPQSDGGPPPGRARSSPHVLPLHQHESTKTRDVRQCVLCQQYGDSPTSDAGRLLYLGQNEWAHVNCCLWSAEVYE-QNGALLQVHSAVSRGRHLRCDRCGQSGATVGC--------CLATCQSNFHFMCA--RAESCVFQADRKVYCCMHRDLVSTKV-VSGAAFEVHRRMYVDFDGI-NLRRKFLTGLEPETITMTIGSLQIQKLGVLSELSSNGRM-LYPVGYQCSRLYWSTVDPRRRCKYTCKVT-EVSTPLPGEE 1563 HSP 3 Score: 105.145 bits (261), Expect = 1.235e-21 Identity = 68/221 (30.77%), Postives = 100/221 (45.25%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGG-DQLIHCVSCAEPFHFFCIEYQFRPK--SKEMFVCRNCTKCHSCDVYGSD----LKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKCQ 4248 GG ++T++ P V C C S G ++I C C EPFH FC+ + P+ SKE + CR C CH C L+C +CQ +HP+C+ P + W C C C CG T + ++ W+ + C C GH C C + Y+ G L+ I+C+ C +H +C GLSE+ + P+ S F CT C+ Sbjct: 950 GGLSILTSIPTTPLPV-CLLCASKGRHEMIFCQICCEPFHSFCLTPEECPQEDSKENWCCRRCKFCHVCGRRSKSAKPVLQCRRCQTCYHPSCLGPTYPKPVNCSLPWVCMTCIRCKSCGV----------TPGKTWDLAWNHEQDLCPECTILNKKGHFCTVCQKCYEDGSRPLQMIQCSECRHWIHPKCEGLSEELCGLMSTLPD----SGGFTCTPCR 1155
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Medaka
Match: kmt2bb (lysine methyltransferase 2B [Source:NCBI gene;Acc:101174945]) HSP 1 Score: 207.223 bits (526), Expect = 1.592e-52 Identity = 124/316 (39.24%), Postives = 170/316 (53.80%), Query Frame = 1 Query: 7180 LRFTIHGFKG----SKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLAD--VVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPK--NHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED--DKLPCTCGSFSCKKYLN 8097 LRF I G + S + W ++ + + R L + G GL H V++L+EQ+ A +C + F+F K Q D V+P+GC R + + D FL S+ P + + L + +A +FR+L + V V S IHGRGLF +R +A E++IEY G VIRS+L+D RE Y G+ CYMFR+D +VDAT GNAARFINHSC PNCY++V+ EG KHI+I A RKIY+GEELTYDY+FPIED +KL C CG+ C+++LN Sbjct: 3497 LRFEITSEDGFSVEADSIEVAWKAVIDGVQEARAIAKLRPLTFQRVTGAGMLGLVHDTVVFLLEQLEGAHRCQKHTFRFFK-------QQSPDDDLPVNPNGCARSELYLRKS----TFDMFNFLASQHRQLPDIGPYDDEEDEVLLKSTRRATSLELPMAMRFRHLER---TSKEAVGVYRSAIHGRGLFCKRNIEAGEMVIEYAGIVIRSVLTDKREKYYDGKGIGCYMFRIDDFDVVDATMHGNAARFINHSCEPNCYSRVINVEGRKHIVIFALRKIYRGEELTYDYKFPIEDASNKLNCNCGARRCRRFLN 3798 HSP 2 Score: 117.857 bits (294), Expect = 1.479e-25 Identity = 67/208 (32.21%), Postives = 104/208 (50.00%), Query Frame = 1 Query: 3616 GGFPVITTVNAQPNKVLCYSCGSGGD-QLIHCVSCAEPFHFFCIEYQFRP--KSKEMFVCRNCTKCHSC----DVYGSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAG---LETIECNSCNRMVHRQCCGLSEDEYEIFKADPEA 4209 GG ++++ P V C+ C S G +++HC C EPFH FC+E RP ++KE + CR C CH C + L+C +CQ +H +C+ P + + W C +C C CG T S EIDW+ D C C++ G+ CP C + Y+ + ++C +CN VH +C L+++ YEI + PE+ Sbjct: 1724 GGLSILSSAPVMPPYV-CFLCASKGQHEMLHCQVCCEPFHRFCLEPAERPSEENKENWCCRRCKFCHVCGKKNQLTKPLLECERCQNCYHASCLGPNYPKLNKKRKAWVCMRCIRCKSCGV----------TPGKSWEIDWNHDKGLCPDCSKLYEQGNYCPICFKCYEDNDYDSQMMQCGTCNHWVHAKCEDLTDELYEILSSLPES 1920 HSP 3 Score: 115.546 bits (288), Expect = 9.362e-25 Identity = 70/214 (32.71%), Postives = 117/214 (54.67%), Query Frame = 1 Query: 5218 SEFNSTICEKDIRHCALCAGSGDDRLE--GRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSM--ACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWS 5847 ++F++ + D R C+LC GD + + GRL+Y G + W HVNC LWS +V+E ++G+L++V A+ +G C C K GAT+ C C +SC + YHF CA + VF + + YC + H + ++ +T + + RR+Y+ +S+ G+ + I V IG+L+I+ +G + E S + L P+G+Q R +WS Sbjct: 2147 ADFDTGWSKDDERQCSLCQKYGDLKPDEAGRLLYLGQNEWAHVNCCLWSAEVFEEDNGSLLHVHSAVTRGRLMRCERCNKTGATVGC--------CLTSCQSNYHFMCARSR--QCVFQDDKKVYCYK-HRHLISGRMITGQEFEVNRRVYV---DFEGISLRRKFLTGLEPEFINVMIGSLQIDKLGVLSELSAS-KGKLFPVGFQCFRWYWS 2345
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Medaka
Match: setd1ba (SET domain containing 1B, histone lysine methyltransferase [Source:NCBI gene;Acc:101162384]) HSP 1 Score: 174.481 bits (441), Expect = 8.763e-43 Identity = 78/147 (53.06%), Postives = 105/147 (71.43%), Query Frame = 1 Query: 7660 NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 N + R K +R C SNIH GLFA A E++IEYVG+ IR +++D+RE Y+ G+ YMFR+D D I+DAT GN ARFINHSC+PNCYAKV+ E +K I+I +++ I EE+TYDY+FPIED+K+PC CG+ +C+ LN Sbjct: 1599 NQLKFRKKKIRFCKSNIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEEEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSRQPINVNEEITYDYKFPIEDEKIPCLCGAENCRGTLN 1745
BLAST of histone lysine N methyltransferase MLL-1 vs. Planmine SMEST
Match: SMESG000027630.1 (SMESG000027630.1) HSP 1 Score: 5103.88 bits (13238), Expect = 0.000e+0 Identity = 2667/2674 (99.74%), Postives = 2669/2674 (99.81%), Query Frame = 1 Query: 79 MGRNKNRNKLQLKSPSQLXXXXXXXXXXXXXXXMYDNENNFESSEXXXXXXXXXXXXXEIQNINESVLIWSNEDVIDENRSKSFHXXXXXXXXXXXXXXXXXXXYLKSQLKDINTIHLSAISGVLMKNEMESDKSSVILNEIPNNNYLKIETKKQSVDNKNSFELPEEIENVDANRRQVSLQETCASPNEPVVRRSGRSAKINYKDMLNIHIYEPVRLTDDWHSPKRKHKVKREPSRPSIRQSTSDNSEVDNRSPERKLIEQKVEFTESEEEKHEGKCTIEYEAQTGYEIKEKEEDKPSQFEIEEERQKHQGVDSDNSHKPNHYQVEENKSNIKRKAFRKPTKDLSRNCIMCSKAVMGSRKFDNLCYNCVVAATKIITRLKLCNNDTRPIVCLGDCGCWERMTDFAERTDILPCDACKIQQLMASGLQWGEQLQWMRTVTLDELRSHEAVQRSRQLQVDQGQAWLNQLTGIEHFGSCLLPDTDLTHAYKWDIRYLVPLGPDGKARCQFCALSHDSDVERSPILEQLYTILPLKETTICQHCLMMAHNAIRNSGLPADGLLQQIRSICPLEPLRYRYFDGAANPDGLCEICMRKDNSVMSRLRSGNLVCLICIWRIKRVHFRSASGDTGADDGKDRIDNHESSCYQQKDQWVLCPINQCDCCLKQLAIRVIELHQIITHYHNPTQLSVHRKPSNIGTSESNRKPKKRTIEHCEESKPKRQCTMTTNPLSIDANWTPIQATSDGQRPRRVIKSTRYNDFIVDDKCLLKSTNERSVKRKSGHIPAQISPTKSYDSKSLLSTGENEQHRILSPDESTHDDMVQKEEEKPIVDDVLVSTSCENVGIADQIVAXXXXXXXXXXHGNQEIKCDNALNIANTSQEELIEHTPTINTDDCTPRRPPQFRRIKQAISTQASKPTELATEEEEIMNQHEESATFVDKEQPVIIAHQTARATSGPRVKQVSRQNLNVDTNIDSTTRQKCVVKRTNRIVKKPETLTNYIIDDHSITXXXXXXXXXXXXXXXSTGRCDSIPLERQSVTGWDGGRCGICAGCNRNRSCGKCDPCLLNKSQRRKTELCVKMICTARXXXXXXXXXXGTKRDKISDIRNTTEVNTLNEASTTDKSVDEITPGTDVSTVCQQLCNGIDVYRXXXXXXXXXXXXXXXXXXXXIHTVKGDLITTGLAHEGGFPVITTVNAQPNKVLCYSCGSGGDQLIHCVSCAEPFHFFCIEYQFRPKSKEMFVCRNCTKCHSCDVYGSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAGLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKCQPPDVAEETEQKKRVRLKRQCKDSGLKQYCERSVQRKTNEFIQKGEAAEEMLLEQHNVSDSAATGYNKGSMSLSQYDGHXXXXXXXKIGGNRGLMSVKDYEGLAMNSPSADMNQTSSTMFCSSESTGECDMDPLNLMDLEHQSVKVDIDVELENIEFESSRATKIGIFSRLNAPDFLSPKHLLMEALARICVKLSRYPSHSQLHKVYERFIGRIEDLTQEIFPWIDFNITMATVQMVVKKYSGRAKLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGREEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICEKDIRHCALCAGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDV-QLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVTKELNNKANGDDLSVSASGVVNQNPATLVATAAIPHRRRMIEMPEQRTTKRSKPMQCKQDIIYEMDEAGNLQPISGFFRSRQPAVATTVFNKVSNNEIAAKKVNRRFPISIASSRVGIVQQSSLNSLSGTEENHRIVPLRRPEXXXXXXXXXXXXXXXXXXXXXXHPASHASQQPYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXDPPVMLRLNKIQPQRLPPSIVKQLNINQNQSKPLTFIHLGQPINRISVKNPPMNNKIFKVMKVATSSSLSPATVGVGNXXXXXXXXXXXXXXKHPSLRIVTSRPPLSSSVLRTVLTDNSHSRRVVVHQQTQPALTIGTSKSSAYHISSCGSIITPSLAQFDGEGDDSSAVTFDEFRSILAAHPAHNVGSDQENASVITMATTTTVAGVKTRKQRANHDYKFCLRFTIHGFKGSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 MGRNKNRNKLQLKSPSQLRNESFSRNNSFNESEMYDNENNFESSENILNNPILLNHINEIQNINESVLIWSNEDVIDENRSKSFHSIVKQEIIKKSIKKSAFSKYLKSQLKDINTIHLSAISGVLMKNEMESDKSSVILNEIPNNNYLKIETKKQSVDNKNSFELPEEIENVDANRRQVSLQETCASPNEPVVRRSGRSAKINYKDMLNIHIYEPVRLTDDWHSPKRKHKVKREPSRPSIRQSTSDNSEVDNRSPERKLIEQKVEFTESEEEKHEGKCTIE+EAQTGYEIKEKEEDKPSQFEIEEERQKHQGVDSDNSHKPNHYQVEENKSNIKRKAFRKPTKDLSRNCIMCSKAVMGSRKFDNLCYNCVVAATKIITRLKLCNNDTRPIVCLGDCGCWERMTDFAERTDILPCDACKIQQLMASGLQWGEQLQWMRTVTLDELRSHEAVQRSRQLQ+DQGQAWLNQLTGIEHFGSCLLPDTDLTHAYKWDIRYLVPLGPDGKARCQFCALSHDSDVERSPILEQLYTILPLKETTICQHCLMMAHNAIRNSGLPADGLLQQIRSICPLEPLRYRYFDGAANPDGLCEICMRKDNSVMSRLRSGNLVCLICIWRIKRVHFRSASGDTGADDGKDRIDNHESSCYQQKDQWVLCPINQCDCCLKQLAIRVIELHQIITHYHNPTQLSVHRKPSNIGTSESNRKPKKRTIEHCEESKPKRQCTMTTNPLSIDANWTPIQATSDGQRPRRVIKSTRYNDFIVDDKCLLKSTNERSVKRKS HIPAQISPTKSYDSKSLLST ENEQHRILSPDESTHDDMVQKEEEKPIVDDVLVSTSCENVGIADQIVAGESDSEGDSSHGNQEIKCDNALNIANTSQEELIEHTPTINTDDCTPRRPPQFRRIKQAISTQASKPTELATEEEEIMNQHEESATFVDKEQPVIIAHQTARATSGPRVKQVSRQNLNVDTNIDSTTRQKCVVKRTNRIVKKPETLTNYIIDDHSITDQMEDDDEDHHLDQLSTGRCDSIPLERQSVTGWDGGRCGICAGCNRNRSCGKCDPCLLNKSQRRKTELCVKMICTARTQTTNQINQIGTKRDKISDIRNTTEVNTLNEASTTDKSVDEITPGTDVSTVCQQLCNGIDVYRDSDSDDLSSEEEQLDPELDSIHTVKGDLITTGLAHEGGFPVITTVNAQPNKVLCYSCGSGGDQLIHCVSCAEPFHFFCIEYQFRPKSKEMFVCRNCTKCHSCDVYGSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAGLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKCQPPDVAEETEQKKRVRLKRQCKDSGLKQYCERSVQRKTNEFIQKGEAAEEMLLEQHNVSDSAATGYNKGSMSLSQYDGHDDEDDEDKIGGN GLMSVKDYEGLAMNSPSADMNQTSSTMFCSSESTGECDMDPLNLMDLEHQSVKVDIDVELENIEFESSRATKIGIFSRLNAPDFLSPKHLLMEALARICVKLSRYPSHSQLHKVYERFIGRIEDLTQEIFPWIDFNITMATVQMVVKKYSGRAKLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGREEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICEKDIRHCALCAGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDV QLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVTKELNNKANGDDLSVSASGVVNQNPATLVATAAIPHRRRMIEMPEQRTTKRSKPMQCKQDIIYEMDEAGNLQPISGFFRSRQPAVATTVFNKVSNNEIAAKKVNRRFPISIASSRVGIVQQSSLNSLSGTEENHRIVPLRRPENINQNTNNIINNCSSSSIIIKSHPASHASQQPYQPQPLSVPRVQQQQQQQQSISQSQMPIIMKQQDPPVMLRLNKIQPQRLPPSIVKQLNINQNQSKPLTFIHLGQPINRISVKNPPMNNKIFKVMKVATSSSLSPATVGVGNSSTSIPISPLTTATKHPSLRIVTSRPPLSSSVLRTVLTDNSHSRRVVVHQQTQPALTIGTSKSSAYHISSCGSIITPSLAQFDGEGDDSSAVTFDEFRSILAAHPAHNVGSDQENASVITMATTTTVAGVKTRKQRANHDYKFCLRFTIHGFKGSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSP GCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAPLNADQLDDNPDPDEDYLRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN Sbjct: 1 MGRNKNRNKLQLKSPSQLRNESFSRNNSFNESEMYDNENNFESSENILNNPILLNHINEIQNINESVLIWSNEDVIDENRSKSFHSIVKQEIIKKSIKKSAFSKYLKSQLKDINTIHLSAISGVLMKNEMESDKSSVILNEIPNNNYLKIETKKQSVDNKNSFELPEEIENVDANRRQVSLQETCASPNEPVVRRSGRSAKINYKDMLNIHIYEPVRLTDDWHSPKRKHKVKREPSRPSIRQSTSDNSEVDNRSPERKLIEQKVEFTESEEEKHEGKCTIEHEAQTGYEIKEKEEDKPSQFEIEEERQKHQGVDSDNSHKPNHYQVEENKSNIKRKAFRKPTKDLSRNCIMCSKAVMGSRKFDNLCYNCVVAATKIITRLKLCNNDTRPIVCLGDCGCWERMTDFAERTDILPCDACKIQQLMASGLQWGEQLQWMRTVTLDELRSHEAVQRSRQLQLDQGQAWLNQLTGIEHFGSCLLPDTDLTHAYKWDIRYLVPLGPDGKARCQFCALSHDSDVERSPILEQLYTILPLKETTICQHCLMMAHNAIRNSGLPADGLLQQIRSICPLEPLRYRYFDGAANPDGLCEICMRKDNSVMSRLRSGNLVCLICIWRIKRVHFRSASGDTGADDGKDRIDNHESSCYQQKDQWVLCPINQCDCCLKQLAIRVIELHQIITHYHNPTQLSVHRKPSNIGTSESNRKPKKRTIEHCEESKPKRQCTMTTNPLSIDANWTPIQATSDGQRPRRVIKSTRYNDFIVDDKCLLKSTNERSVKRKSDHIPAQISPTKSYDSKSLLSTCENEQHRILSPDESTHDDMVQKEEEKPIVDDVLVSTSCENVGIADQIVAGESDSEGDSSHGNQEIKCDNALNIANTSQEELIEHTPTINTDDCTPRRPPQFRRIKQAISTQASKPTELATEEEEIMNQHEESATFVDKEQPVIIAHQTARATSGPRVKQVSRQNLNVDTNIDSTTRQKCVVKRTNRIVKKPETLTNYIIDDHSITDQMEDDDEDHHLDQLSTGRCDSIPLERQSVTGWDGGRCGICAGCNRNRSCGKCDPCLLNKSQRRKTELCVKMICTARTQTTNQINQIGTKRDKISDIRNTTEVNTLNEASTTDKSVDEITPGTDVSTVCQQLCNGIDVYRDSDSDDLSSEEEQLDPELDSIHTVKGDLITTGLAHEGGFPVITTVNAQPNKVLCYSCGSGGDQLIHCVSCAEPFHFFCIEYQFRPKSKEMFVCRNCTKCHSCDVYGSDLKCIKCQLGFHPTCVDKYPPTRSDDKSNWACYKCAMCLHCGAKAEDAMTHHNTNKFSGEIDWSKDPWQCGRCARARINGHVCPECGRAYQAGLETIECNSCNRMVHRQCCGLSEDEYEIFKADPEAHCSSNAFLCTKCQPPDVAEETEQKKRVRLKRQCKDSGLKQYCERSVQRKTNEFIQKGEAAEEMLLEQHNVSDSAATGYNKGSMSLSQYDGHDDEDDEDKIGGNGGLMSVKDYEGLAMNSPSADMNQTSSTMFCSSESTGECDMDPLNLMDLEHQSVKVDIDVELENIEFESSRATKIGIFSRLNAPDFLSPKHLLMEALARICVKLSRYPSHSQLHKVYERFIGRIEDLTQEIFPWIDFNITMATVQMVVKKYSGRAKLIMQALAENVRDNINREFDVFSSSITEIEEKLSNSFQRGREEFIIFHSEQHLSALMKSIEFQYDADSTSTATYNVAFPSEFNSTICEKDIRHCALCAGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMGKIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMYYMNVTKELNNKANGDDLSVSASGVVNQNPATLVATAAIPHRRRMIEMPEQRTTKRSKPMQCKQDIIYEMDEAGNLQPISGFFRSRQPAVATTVFNKVSNNEIAAKKVNRRFPISIASSRVGIVQQSSLNSLSGTEENHRIVPLRRPENINQNTNNIINNCSSSSIIIKSHPASHASQQPYQPQPLSVPRVQQQQQQQQSISQSQMPIIMKQQDPPVMLRLNKIQPQRLPPSIVKQLNINQNQSKPLTFIHLGQPINRISVKNPPMNNKIFKVMKVATSSSLSPATVGVGNSSTSIPISPLTTATKHPSLRIVTSRPPLSSSVLRTVLTDNSHSRRVVVHQQTQPALTIGTSKSSAYHISSCGSIITPSLAQFDGEGDDSSAVTFDEFRSILAAHPAHNVGSDQENASVITMATTTTVAGVKTRKQRANHDYKFCLRFTIHGFKGSKSPKSGWGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPRGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAPLNADQLDDNPDPDEDYLRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 2674
BLAST of histone lysine N methyltransferase MLL-1 vs. Planmine SMEST
Match: SMESG000071222.1 (SMESG000071222.1) HSP 1 Score: 162.54 bits (410), Expect = 1.825e-39 Identity = 110/326 (33.74%), Postives = 171/326 (52.45%), Query Frame = 1 Query: 7174 FCLRFTIHGFKGSKSPKSG---WGLIVKRITQMRKSQGLME-YPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSPHGCVRFNQWTKTKPDHIAR---------DPLAFLHSK--SNYPPKNHAXXXXXXXXXXXXXXXXXXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIED---DKLPCTCGSFSCKKYLN 8097 F ++F +G + + KS W I+ +I ++R+ GL +PV G +GL +I ++E + NY FKF K ++ + ++P G R +T ++ R + L +K +NY P + N ++ + Y R L ++RN N + +R+K I G GLFA + F+ +IIEY+GE+IR+ + + RE YQ YMFRL++DLI+DAT G AR+INHSC+PNC A+ + + III ++ I +GEELTYDY+F ED DK+PC CGS +C+K++N Sbjct: 1028 FKVKFIDNGCENVLTDKSCDKLWKTILNKIAKLRQDSGLTRLFPVY-LSGEQLYGLTEPQIIRVIESLPGVEMIKNYAFKFGKMQLI----TEMPLAINPTGSARTEPKLRT---YVRRMRDYQETKFNKCGILKAKPNNNYQPIIYDNGNLNKTALLNSKTQQYKR-LKYEWRN--NVILSRSK--------IQGLGLFAAKDFEKSTMIIEYLGEIIRNEVGNSREKLYQARNNSIYMFRLNEDLIIDATVNGGLARYINHSCNPNCVAETLSLDCGSRIIITTRQLIERGEELTYDYKFDFEDNKADKIPCLCGSINCRKWMN 1334 HSP 2 Score: 105.531 bits (262), Expect = 4.344e-22 Identity = 69/225 (30.67%), Postives = 109/225 (48.44%), Query Frame = 1 Query: 5248 DIRHCALC--AGSGDDRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASD---NIVVTIGNLRINCMGKI----------DECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 D+R C LC G GD+ + GRLI D WVH+NCALW +V+E G+L+ VD ++RK K +C C + GA ++C S C NVYH CA+ + +F R YC ++ V + + L + + RR+ + L + S V D I G+L +N +G++ + CS + P+GY + R++WS +++ Y Sbjct: 813 DVRSCVLCRNVGDGDEDICGRLINIDADNWVHLNCALWCFEVFETVSGSLMEVDSSLRKAIKTICTCCNETGAGIQCYR--------SKCTNVYHVPCAYKV--GCIFYTDRGMYCP---NHVVLNHPMHLPSLRVERRVNI----LRDESALIAGMVTEDQDVKIKFRTGSLTLNNIGQLLPEQLISGNYNSCS-----IIYPVGYHSTRIYWSSTQINKRCKY 1015
BLAST of histone lysine N methyltransferase MLL-1 vs. Planmine SMEST
Match: SMESG000064115.1 (SMESG000064115.1) HSP 1 Score: 161.77 bits (408), Expect = 4.382e-39 Identity = 98/299 (32.78%), Postives = 160/299 (53.51%), Query Frame = 1 Query: 7231 WGLIVKRITQMRKSQGLMEYPVRNGDGWAKFGLDHRHVIYLVEQMVSAFQCNNYEFKFHKTRVTKLRNQYLADVVSP---HGCVRFNQWTKTKPDHIARDPLAFLHSKSNYPPKNHAXXXXXXXXXXXXXXXX----XXRTLADQFRNLRNGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGVDCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIE---DDKLPCTCGSFSCKKYLN 8097 W I+ +I+ +RKS ++++ + +GL HV+ +E + N+Y FKF K Q + ++ P G +R + K HI + +H N+ H A + ++ TL+ +++ R V + S I G GL+A + + +IIEYVGE+IR+ ++++RE +Y+ YMFRLD ++DAT G+ AR+INH C PNC+ +++ FE E HI+II+ RKI KGEELTYDY+F ++ DDK+PC CG+ +C++++N Sbjct: 1179 WKKILTKISNLRKSHKVVKFFPEHIKAEDLYGLTEPHVLRAIESLPGLESLNDYAFKFGKM-------QLIVEMPLPINMSGSIRTEPFVKLY-RHIHK---PAIHQSPNF--LRHLLAAAAATATSGKIPDNILFNNKTTLSSKWQQYRKLKFETKFNVVLKRSKIQGFGLYAAKDLEKGTMIIEYVGELIRNEVANIREKQYESKKQGIYMFRLDPSTVIDATRAGDLARYINHCCDPNCFTELLDFEKESHIVIISNRKIEKGEELTYDYKFDLDDGKDDKIPCLCGARNCRRWMN 1464 HSP 2 Score: 89.7373 bits (221), Expect = 2.975e-17 Identity = 62/217 (28.57%), Postives = 104/217 (47.93%), Query Frame = 1 Query: 5248 DIRHCALCAGSGD--DRLEGRLIYGGLDVWVHVNCALWSDDVYEREDGALVNVDIAIRKGEKALCAACQKYGATLRCSAPDSLDGCGSSCPNVYHFACAFNMLPDPVFTELRTFYCSESHDNCVTDVQLTLVDMPILRRIYLPQGCLANVSMACTDGVASDNIVVTIGNLRINCMG-----KIDECSDYLRVYLCPIGYQARRLFWSMYELDSLVMY 5877 D R C+LC +GD + GRL+ +D W+H+NCALW ++V+E + GAL NV + K++C++C K GA + C P C YH CA +F R YC D+ L + + RR+Y+ + + V A T N + IG+L + +G +I + + ++ P G+++ R+ WS +++ +Y Sbjct: 940 DKRTCSLCHRTGDLPENGPGRLLCFDVDKWLHINCALWCNNVFEMQCGALNNVPESFEASLKSICSSCGKPGAGIVCYYP--------RCTLKYHVPCA--QEKGCLFFADRAMYCQLHQ---TKDLGPHLTTLNVDRRVYISRDEYSQV--AGTINNEDQNFFLRIGSLVVLSIGQLLPHQIHSGNFHNLNHVYPTGFKSHRIHWSSRVINTRSVY 1141
BLAST of histone lysine N methyltransferase MLL-1 vs. Planmine SMEST
Match: SMESG000062296.1 (SMESG000062296.1) HSP 1 Score: 159.844 bits (403), Expect = 1.570e-38 Identity = 76/166 (45.78%), Postives = 106/166 (63.86%), Query Frame = 1 Query: 7627 RTLADQFRNLR--------NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 R L F+NL N + AR K + S IH GL A E++IEYVG+V+R L++ RE +Y+ G+ Y+FR+D DL++DAT G+ ARFINHSC PNC A+V+ +G+K I+I ++R+I EE+TYDY+FP E+DK+PC CGS C+ LN Sbjct: 1230 RRLQTGFQNLESTGELLRINHLGARKKLMTFAKSGIHAWGLVALETIAPDEMVIEYVGQVVRKFLAEYREKKYEDKGIGSSYLFRIDDDLVIDATMYGSNARFINHSCQPNCIARVITVDGKKKIVIYSKRQINIMEEITYDYKFPYEEDKIPCLCGSVGCRGTLN 1395
BLAST of histone lysine N methyltransferase MLL-1 vs. Planmine SMEST
Match: SMESG000062296.1 (SMESG000062296.1) HSP 1 Score: 159.458 bits (402), Expect = 1.704e-38 Identity = 76/166 (45.78%), Postives = 106/166 (63.86%), Query Frame = 1 Query: 7627 RTLADQFRNLR--------NGMDARAKTVRVCVSNIHGRGLFARRQFDAHEIIIEYVGEVIRSILSDVRETEYQRTGV-DCYMFRLDQDLIVDATFKGNAARFINHSCHPNCYAKVVRFEGEKHIIIIAQRKIYKGEELTYDYRFPIEDDKLPCTCGSFSCKKYLN 8097 R L F+NL N + AR K + S IH GL A E++IEYVG+V+R L++ RE +Y+ G+ Y+FR+D DL++DAT G+ ARFINHSC PNC A+V+ +G+K I+I ++R+I EE+TYDY+FP E+DK+PC CGS C+ LN Sbjct: 1248 RRLQTGFQNLESTGELLRINHLGARKKLMTFAKSGIHAWGLVALETIAPDEMVIEYVGQVVRKFLAEYREKKYEDKGIGSSYLFRIDDDLVIDATMYGSNARFINHSCQPNCIARVITVDGKKKIVIYSKRQINIMEEITYDYKFPYEEDKIPCLCGSVGCRGTLN 1413 The following BLAST results are available for this feature:
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 2
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of histone lysine N methyltransferase MLL-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029784 ID=SMED30029784|Name=histone lysine N methyltransferase MLL-1|organism=Schmidtea mediterranea sexual|type=transcript|length=8548bpback to top protein sequence of SMED30029784-orf-1 >SMED30029784-orf-1 ID=SMED30029784-orf-1|Name=SMED30029784-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=124bp MRSLPSSAPVSPLAERKCTRLMRQMQMRQTRLPERNRDITELSLRMQISQback to top protein sequence of SMED30029784-orf-2 >SMED30029784-orf-2 ID=SMED30029784-orf-2|Name=SMED30029784-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=110bp MRIHKCKLANTSQSSRRASFGLAVHRKRLFRKLIEVFLAAETAAGARQFIback to top protein sequence of SMED30029784-orf-3 >SMED30029784-orf-3 ID=SMED30029784-orf-3|Name=SMED30029784-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=2674bp MGRNKNRNKLQLKSPSQLRNESFSRNNSFNESEMYDNENNFESSENILNNback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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