patched-like protein
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029695 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 15
Homology
BLAST of patched-like protein vs. Ensembl Human
Match: PTCH1 (patched 1 [Source:HGNC Symbol;Acc:HGNC:9585]) HSP 1 Score: 222.246 bits (565), Expect = 7.789e-58 Identity = 238/948 (25.11%), Postives = 428/948 (45.15%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKPSYESIV-NEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINP------VDLSPRSE------------------PSTSRSFPLNSSVDNN----LEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP N+ KP ++V N GC + + + + +G K++ G LQT L + + E K ++++ W E K ++ W R Y+E + A+ +Q++ SF T + + + D +++ + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC T + P+ Y ++ S F + + V E +P PRSE STS + L S ++ LEP K W K + ++ ++ VI + L ++ + LY + GL I PR++ E+ +I + + F F N IVT++ +Y N Q +L LH+ N+ +V L EN K WL F WL+ +Q FD D + I+ N +N S +G+L L+VQ G + I+ +L+ RLV +G ++ FY++L W S V Y + P + D + Y E + L + + P+++ ++ G + + + ++ ++ VR+I S YT +L L + P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 154 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAW-------------QRTYVEVVHQSVAQNSTQKVL--SFTTTTLDDILKSF----SDVSVIR--VASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF----TSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK-------WTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDK---ADYMPE------TRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1039
BLAST of patched-like protein vs. Ensembl Human
Match: PTCH1 (patched 1 [Source:HGNC Symbol;Acc:HGNC:9585]) HSP 1 Score: 222.246 bits (565), Expect = 7.789e-58 Identity = 238/948 (25.11%), Postives = 428/948 (45.15%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKPSYESIV-NEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINP------VDLSPRSE------------------PSTSRSFPLNSSVDNN----LEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP N+ KP ++V N GC + + + + +G K++ G LQT L + + E K ++++ W E K ++ W R Y+E + A+ +Q++ SF T + + + D +++ + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC T + P+ Y ++ S F + + V E +P PRSE STS + L S ++ LEP K W K + ++ ++ VI + L ++ + LY + GL I PR++ E+ +I + + F F N IVT++ +Y N Q +L LH+ N+ +V L EN K WL F WL+ +Q FD D + I+ N +N S +G+L L+VQ G + I+ +L+ RLV +G ++ FY++L W S V Y + P + D + Y E + L + + P+++ ++ G + + + ++ ++ VR+I S YT +L L + P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 154 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAW-------------QRTYVEVVHQSVAQNSTQKVL--SFTTTTLDDILKSF----SDVSVIR--VASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF----TSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK-------WTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDK---ADYMPE------TRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1039
BLAST of patched-like protein vs. Ensembl Human
Match: PTCH1 (patched 1 [Source:HGNC Symbol;Acc:HGNC:9585]) HSP 1 Score: 222.246 bits (565), Expect = 7.965e-58 Identity = 238/948 (25.11%), Postives = 428/948 (45.15%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKPSYESIV-NEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINP------VDLSPRSE------------------PSTSRSFPLNSSVDNN----LEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP N+ KP ++V N GC + + + + +G K++ G LQT L + + E K ++++ W E K ++ W R Y+E + A+ +Q++ SF T + + + D +++ + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC T + P+ Y ++ S F + + V E +P PRSE STS + L S ++ LEP K W K + ++ ++ VI + L ++ + LY + GL I PR++ E+ +I + + F F N IVT++ +Y N Q +L LH+ N+ +V L EN K WL F WL+ +Q FD D + I+ N +N S +G+L L+VQ G + I+ +L+ RLV +G ++ FY++L W S V Y + P + D + Y E + L + + P+++ ++ G + + + ++ ++ VR+I S YT +L L + P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 219 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAW-------------QRTYVEVVHQSVAQNSTQKVL--SFTTTTLDDILKSF----SDVSVIR--VASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF----TSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK-------WTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDK---ADYMPE------TRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1104
BLAST of patched-like protein vs. Ensembl Human
Match: PTCH1 (patched 1 [Source:HGNC Symbol;Acc:HGNC:9585]) HSP 1 Score: 221.861 bits (564), Expect = 8.496e-58 Identity = 238/948 (25.11%), Postives = 428/948 (45.15%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKPSYESIV-NEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINP------VDLSPRSE------------------PSTSRSFPLNSSVDNN----LEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP N+ KP ++V N GC + + + + +G K++ G LQT L + + E K ++++ W E K ++ W R Y+E + A+ +Q++ SF T + + + D +++ + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC T + P+ Y ++ S F + + V E +P PRSE STS + L S ++ LEP K W K + ++ ++ VI + L ++ + LY + GL I PR++ E+ +I + + F F N IVT++ +Y N Q +L LH+ N+ +V L EN K WL F WL+ +Q FD D + I+ N +N S +G+L L+VQ G + I+ +L+ RLV +G ++ FY++L W S V Y + P + D + Y E + L + + P+++ ++ G + + + ++ ++ VR+I S YT +L L + P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 69 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAW-------------QRTYVEVVHQSVAQNSTQKVL--SFTTTTLDDILKSF----SDVSVIR--VASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF----TSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK-------WTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDK---ADYMPE------TRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 954
BLAST of patched-like protein vs. Ensembl Human
Match: PTCH1 (patched 1 [Source:HGNC Symbol;Acc:HGNC:9585]) HSP 1 Score: 221.861 bits (564), Expect = 8.496e-58 Identity = 238/948 (25.11%), Postives = 428/948 (45.15%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKPSYESIV-NEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINP------VDLSPRSE------------------PSTSRSFPLNSSVDNN----LEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP N+ KP ++V N GC + + + + +G K++ G LQT L + + E K ++++ W E K ++ W R Y+E + A+ +Q++ SF T + + + D +++ + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC T + P+ Y ++ S F + + V E +P PRSE STS + L S ++ LEP K W K + ++ ++ VI + L ++ + LY + GL I PR++ E+ +I + + F F N IVT++ +Y N Q +L LH+ N+ +V L EN K WL F WL+ +Q FD D + I+ N +N S +G+L L+VQ G + I+ +L+ RLV +G ++ FY++L W S V Y + P + D + Y E + L + + P+++ ++ G + + + ++ ++ VR+I S YT +L L + P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 69 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAW-------------QRTYVEVVHQSVAQNSTQKVL--SFTTTTLDDILKSF----SDVSVIR--VASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF----TSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK-------WTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDK---ADYMPE------TRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 954
BLAST of patched-like protein vs. Ensembl Celegans
Match: ptc-1 (pep chromosome:WBcel235:II:7895625:7900484:1 gene:WBGene00004208.1 transcript:ZK675.1b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ptc-1) HSP 1 Score: 83.1889 bits (204), Expect = 1.224e-15 Identity = 109/478 (22.80%), Postives = 188/478 (39.33%), Query Frame = 1
Query: 2314 GLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTK--EFEYTNNQDILLQLHQEIDNLHHVALLENG----KFWLSSFIGWLERIQSDFDRDV-KNKLILANGT-WSRNASKNGLLVMTLMVQDGESIN-YKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTV-----DNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEEL-DFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMF-VISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSD 3693
GL + P + +++ + F F V K +Y + Q + Q I + +V +N K+WL WL IQ FD +V K L +GT N S++ L LM G ++ RLV +G ++ FY +L W ++ + Y +P + + +NF P+ PL + ++ G + + D +K +RS+ R+T+ LP P G FT EQYL L L+ I+ I +F VIS+L N + A ++ +L + FM L I LN S V + + G+G F++ ++VS++ ++ T ++RT V+R F VP FST LG+ + ++ F+ + F ++ + ++N L P+ + P+ +
Sbjct: 786 GLELGDVLPEHTAPAQFLRARDKYFSFYPMFAVIKGPNIDYAHQQRQIDNYRQSIGSSKYVIKNKNEEPSEKYWLGLMRDWLISIQRGFDEEVAKGSFNLTSGTVIGSNVSEDARLAHALMCSHGSLFGCAGRVGKIRLVDASGIINSDGFYNYLTAWFNVDHMMYYVSQASFFPTPPKWELSKNHTENFIPAA------------------EPLAYSQIPFYLTGLTDTAVIVDAIKDIRSVCERFTDQ-GLPNFPQGIAFTFWEQYLFLTGNLMQAISIITISVFCVISVLLFNPWAALMVVCILGIMTCELAG-FMGLVGIKLNPVSAVTLITAVGIGVEFTVHVVVSFL----------------------TALGTRSQRTSS-----------------------AVDRVF--VPVIHGSFSTLLGILMLGFSEFEFVVKYFFIVMTALICIGIINGLILLPVLLSWFGPRRE 1196 HSP 2 Score: 69.3218 bits (168), Expect = 2.426e-11 Identity = 41/140 (29.29%), Postives = 72/140 (51.43%), Query Frame = 1
Query: 1522 FNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPR 1941
FNA TTQ+VPF+ +G+G++ + +L Y D+ + H +IL S + L L+ T++P+P +R+FC Q ++ +YP ++ +D R+++ R DL+CCL + ESYS + +
Sbjct: 573 FNAATTQIVPFLTLGIGVDNMFMLLHNYR---DVVKLAGGHAEMAILMRETGMSILCTSINNILSFLTG-TLLPIPALRSFCAQSSILLTFNFIAILTIYPAIISIDLRRKKAQRRDLVCCLYG----DTREESYSMISK 704 HSP 3 Score: 68.5514 bits (166), Expect = 3.829e-11 Identity = 54/229 (23.58%), Postives = 91/229 (39.74%), Query Frame = 1
Query: 361 VEFETDVMNLWIYNSSRLHNETSFISRV----------SGSKIE-----SGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRS--FTFSDFCQRVQLPKLHYLHDRS-LRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDE--------SRSIKIDWKSFN---ISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLK 960
V ETD++ LW+ RL E +F+ + SG ++ G + ++Q + + + + ++ SD C + P + S L ++ ++PC I+P++CFWEGSK L + S+ S I W F+ + E SF S+Y F F+ AG+ G++ +PC+D D CP K
Sbjct: 13 VHIETDIVKLWVAQGGRLDEELNFLPNIKEAMRNVTGDSGPELPRENGLGGGYQVLIQTPEYEGQDALAAGPLLKHVEIMKHIASFNVSVHGVDWSLSDICFKPAPPSVAADSAASSLGDVIDKIVPCIWITPIDCFWEGSKALGPHPSLPKSSLGPLGMLLSSLSDGDMIRWSDFDPIAVIDEIHRSFNLGSHYTF----FERAGVSHGYMDRPCIDPLDPECPPMAK 237
BLAST of patched-like protein vs. Ensembl Celegans
Match: ptc-1 (pep chromosome:WBcel235:II:7895625:7900484:1 gene:WBGene00004208.1 transcript:ZK675.1b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ptc-1) HSP 1 Score: 83.1889 bits (204), Expect = 1.224e-15 Identity = 109/478 (22.80%), Postives = 188/478 (39.33%), Query Frame = 1
Query: 2314 GLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTK--EFEYTNNQDILLQLHQEIDNLHHVALLENG----KFWLSSFIGWLERIQSDFDRDV-KNKLILANGT-WSRNASKNGLLVMTLMVQDGESIN-YKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTV-----DNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEEL-DFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMF-VISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSD 3693
GL + P + +++ + F F V K +Y + Q + Q I + +V +N K+WL WL IQ FD +V K L +GT N S++ L LM G ++ RLV +G ++ FY +L W ++ + Y +P + + +NF P+ PL + ++ G + + D +K +RS+ R+T+ LP P G FT EQYL L L+ I+ I +F VIS+L N + A ++ +L + FM L I LN S V + + G+G F++ ++VS++ ++ T ++RT V+R F VP FST LG+ + ++ F+ + F ++ + ++N L P+ + P+ +
Sbjct: 786 GLELGDVLPEHTAPAQFLRARDKYFSFYPMFAVIKGPNIDYAHQQRQIDNYRQSIGSSKYVIKNKNEEPSEKYWLGLMRDWLISIQRGFDEEVAKGSFNLTSGTVIGSNVSEDARLAHALMCSHGSLFGCAGRVGKIRLVDASGIINSDGFYNYLTAWFNVDHMMYYVSQASFFPTPPKWELSKNHTENFIPAA------------------EPLAYSQIPFYLTGLTDTAVIVDAIKDIRSVCERFTDQ-GLPNFPQGIAFTFWEQYLFLTGNLMQAISIITISVFCVISVLLFNPWAALMVVCILGIMTCELAG-FMGLVGIKLNPVSAVTLITAVGIGVEFTVHVVVSFL----------------------TALGTRSQRTSS-----------------------AVDRVF--VPVIHGSFSTLLGILMLGFSEFEFVVKYFFIVMTALICIGIINGLILLPVLLSWFGPRRE 1196 HSP 2 Score: 69.3218 bits (168), Expect = 2.426e-11 Identity = 41/140 (29.29%), Postives = 72/140 (51.43%), Query Frame = 1
Query: 1522 FNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPR 1941
FNA TTQ+VPF+ +G+G++ + +L Y D+ + H +IL S + L L+ T++P+P +R+FC Q ++ +YP ++ +D R+++ R DL+CCL + ESYS + +
Sbjct: 573 FNAATTQIVPFLTLGIGVDNMFMLLHNYR---DVVKLAGGHAEMAILMRETGMSILCTSINNILSFLTG-TLLPIPALRSFCAQSSILLTFNFIAILTIYPAIISIDLRRKKAQRRDLVCCLYG----DTREESYSMISK 704 HSP 3 Score: 68.5514 bits (166), Expect = 3.829e-11 Identity = 54/229 (23.58%), Postives = 91/229 (39.74%), Query Frame = 1
Query: 361 VEFETDVMNLWIYNSSRLHNETSFISRV----------SGSKIE-----SGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRS--FTFSDFCQRVQLPKLHYLHDRS-LRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDE--------SRSIKIDWKSFN---ISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLK 960
V ETD++ LW+ RL E +F+ + SG ++ G + ++Q + + + + ++ SD C + P + S L ++ ++PC I+P++CFWEGSK L + S+ S I W F+ + E SF S+Y F F+ AG+ G++ +PC+D D CP K
Sbjct: 13 VHIETDIVKLWVAQGGRLDEELNFLPNIKEAMRNVTGDSGPELPRENGLGGGYQVLIQTPEYEGQDALAAGPLLKHVEIMKHIASFNVSVHGVDWSLSDICFKPAPPSVAADSAASSLGDVIDKIVPCIWITPIDCFWEGSKALGPHPSLPKSSLGPLGMLLSSLSDGDMIRWSDFDPIAVIDEIHRSFNLGSHYTF----FERAGVSHGYMDRPCIDPLDPECPPMAK 237
BLAST of patched-like protein vs. Ensembl Celegans
Match: ptc-1 (pep chromosome:WBcel235:II:7893229:7900484:1 gene:WBGene00004208.1 transcript:ZK675.1a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ptc-1) HSP 1 Score: 83.1889 bits (204), Expect = 1.272e-15 Identity = 109/478 (22.80%), Postives = 188/478 (39.33%), Query Frame = 1
Query: 2314 GLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTK--EFEYTNNQDILLQLHQEIDNLHHVALLENG----KFWLSSFIGWLERIQSDFDRDV-KNKLILANGT-WSRNASKNGLLVMTLMVQDGESIN-YKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTV-----DNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEEL-DFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMF-VISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSD 3693
GL + P + +++ + F F V K +Y + Q + Q I + +V +N K+WL WL IQ FD +V K L +GT N S++ L LM G ++ RLV +G ++ FY +L W ++ + Y +P + + +NF P+ PL + ++ G + + D +K +RS+ R+T+ LP P G FT EQYL L L+ I+ I +F VIS+L N + A ++ +L + FM L I LN S V + + G+G F++ ++VS++ ++ T ++RT V+R F VP FST LG+ + ++ F+ + F ++ + ++N L P+ + P+ +
Sbjct: 928 GLELGDVLPEHTAPAQFLRARDKYFSFYPMFAVIKGPNIDYAHQQRQIDNYRQSIGSSKYVIKNKNEEPSEKYWLGLMRDWLISIQRGFDEEVAKGSFNLTSGTVIGSNVSEDARLAHALMCSHGSLFGCAGRVGKIRLVDASGIINSDGFYNYLTAWFNVDHMMYYVSQASFFPTPPKWELSKNHTENFIPAA------------------EPLAYSQIPFYLTGLTDTAVIVDAIKDIRSVCERFTDQ-GLPNFPQGIAFTFWEQYLFLTGNLMQAISIITISVFCVISVLLFNPWAALMVVCILGIMTCELAG-FMGLVGIKLNPVSAVTLITAVGIGVEFTVHVVVSFL----------------------TALGTRSQRTSS-----------------------AVDRVF--VPVIHGSFSTLLGILMLGFSEFEFVVKYFFIVMTALICIGIINGLILLPVLLSWFGPRRE 1338 HSP 2 Score: 69.707 bits (169), Expect = 1.767e-11 Identity = 41/140 (29.29%), Postives = 72/140 (51.43%), Query Frame = 1
Query: 1522 FNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPR 1941
FNA TTQ+VPF+ +G+G++ + +L Y D+ + H +IL S + L L+ T++P+P +R+FC Q ++ +YP ++ +D R+++ R DL+CCL + ESYS + +
Sbjct: 715 FNAATTQIVPFLTLGIGVDNMFMLLHNYR---DVVKLAGGHAEMAILMRETGMSILCTSINNILSFLTG-TLLPIPALRSFCAQSSILLTFNFIAILTIYPAIISIDLRRKKAQRRDLVCCLYG----DTREESYSMISK 846 HSP 3 Score: 68.1662 bits (165), Expect = 4.950e-11 Identity = 54/229 (23.58%), Postives = 91/229 (39.74%), Query Frame = 1
Query: 361 VEFETDVMNLWIYNSSRLHNETSFISRV----------SGSKIE-----SGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRS--FTFSDFCQRVQLPKLHYLHDRS-LRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDE--------SRSIKIDWKSFN---ISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLK 960
V ETD++ LW+ RL E +F+ + SG ++ G + ++Q + + + + ++ SD C + P + S L ++ ++PC I+P++CFWEGSK L + S+ S I W F+ + E SF S+Y F F+ AG+ G++ +PC+D D CP K
Sbjct: 155 VHIETDIVKLWVAQGGRLDEELNFLPNIKEAMRNVTGDSGPELPRENGLGGGYQVLIQTPEYEGQDALAAGPLLKHVEIMKHIASFNVSVHGVDWSLSDICFKPAPPSVAADSAASSLGDVIDKIVPCIWITPIDCFWEGSKALGPHPSLPKSSLGPLGMLLSSLSDGDMIRWSDFDPIAVIDEIHRSFNLGSHYTF----FERAGVSHGYMDRPCIDPLDPECPPMAK 379
BLAST of patched-like protein vs. Ensembl Celegans
Match: ptc-1 (pep chromosome:WBcel235:II:7893229:7900510:1 gene:WBGene00004208.1 transcript:ZK675.1a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ptc-1) HSP 1 Score: 83.1889 bits (204), Expect = 1.272e-15 Identity = 109/478 (22.80%), Postives = 188/478 (39.33%), Query Frame = 1
Query: 2314 GLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTK--EFEYTNNQDILLQLHQEIDNLHHVALLENG----KFWLSSFIGWLERIQSDFDRDV-KNKLILANGT-WSRNASKNGLLVMTLMVQDGESIN-YKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTV-----DNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEEL-DFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMF-VISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSD 3693
GL + P + +++ + F F V K +Y + Q + Q I + +V +N K+WL WL IQ FD +V K L +GT N S++ L LM G ++ RLV +G ++ FY +L W ++ + Y +P + + +NF P+ PL + ++ G + + D +K +RS+ R+T+ LP P G FT EQYL L L+ I+ I +F VIS+L N + A ++ +L + FM L I LN S V + + G+G F++ ++VS++ ++ T ++RT V+R F VP FST LG+ + ++ F+ + F ++ + ++N L P+ + P+ +
Sbjct: 928 GLELGDVLPEHTAPAQFLRARDKYFSFYPMFAVIKGPNIDYAHQQRQIDNYRQSIGSSKYVIKNKNEEPSEKYWLGLMRDWLISIQRGFDEEVAKGSFNLTSGTVIGSNVSEDARLAHALMCSHGSLFGCAGRVGKIRLVDASGIINSDGFYNYLTAWFNVDHMMYYVSQASFFPTPPKWELSKNHTENFIPAA------------------EPLAYSQIPFYLTGLTDTAVIVDAIKDIRSVCERFTDQ-GLPNFPQGIAFTFWEQYLFLTGNLMQAISIITISVFCVISVLLFNPWAALMVVCILGIMTCELAG-FMGLVGIKLNPVSAVTLITAVGIGVEFTVHVVVSFL----------------------TALGTRSQRTSS-----------------------AVDRVF--VPVIHGSFSTLLGILMLGFSEFEFVVKYFFIVMTALICIGIINGLILLPVLLSWFGPRRE 1338 HSP 2 Score: 69.707 bits (169), Expect = 1.767e-11 Identity = 41/140 (29.29%), Postives = 72/140 (51.43%), Query Frame = 1
Query: 1522 FNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPR 1941
FNA TTQ+VPF+ +G+G++ + +L Y D+ + H +IL S + L L+ T++P+P +R+FC Q ++ +YP ++ +D R+++ R DL+CCL + ESYS + +
Sbjct: 715 FNAATTQIVPFLTLGIGVDNMFMLLHNYR---DVVKLAGGHAEMAILMRETGMSILCTSINNILSFLTG-TLLPIPALRSFCAQSSILLTFNFIAILTIYPAIISIDLRRKKAQRRDLVCCLYG----DTREESYSMISK 846 HSP 3 Score: 68.1662 bits (165), Expect = 4.950e-11 Identity = 54/229 (23.58%), Postives = 91/229 (39.74%), Query Frame = 1
Query: 361 VEFETDVMNLWIYNSSRLHNETSFISRV----------SGSKIE-----SGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRS--FTFSDFCQRVQLPKLHYLHDRS-LRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDE--------SRSIKIDWKSFN---ISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLK 960
V ETD++ LW+ RL E +F+ + SG ++ G + ++Q + + + + ++ SD C + P + S L ++ ++PC I+P++CFWEGSK L + S+ S I W F+ + E SF S+Y F F+ AG+ G++ +PC+D D CP K
Sbjct: 155 VHIETDIVKLWVAQGGRLDEELNFLPNIKEAMRNVTGDSGPELPRENGLGGGYQVLIQTPEYEGQDALAAGPLLKHVEIMKHIASFNVSVHGVDWSLSDICFKPAPPSVAADSAASSLGDVIDKIVPCIWITPIDCFWEGSKALGPHPSLPKSSLGPLGMLLSSLSDGDMIRWSDFDPIAVIDEIHRSFNLGSHYTF----FERAGVSHGYMDRPCIDPLDPECPPMAK 379
BLAST of patched-like protein vs. Ensembl Celegans
Match: ptc-3 (pep chromosome:WBcel235:II:2845384:2852593:-1 gene:WBGene00004210.1 transcript:Y110A2AL.8a.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:ptc-3) HSP 1 Score: 67.781 bits (164), Expect = 6.372e-11 Identity = 36/132 (27.27%), Postives = 70/132 (53.03%), Query Frame = 1
Query: 1522 FNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDST 1917
FNA TTQVVPF+ +GLG++++ +L Y + I+IC + + + L + +M++ ++ + ++P+P +R+FC Q ++ F++P ++ +D R+ + DL C R P +T
Sbjct: 679 FNAATTQVVPFLSLGLGIDDMFLLLHNYDEIINICNK-----NEIGVLLKETGMSVMLTSINNILAFISGYVLPIPALRSFCSQTAILLAFNLIFLMFIFPAMIGIDLRRQRKGKRDLAYC--SRGNPQMAT 803
BLAST of patched-like protein vs. Ensembl Fly
Match: ptc (gene:FBgn0003892 transcript:FBtr0089427) HSP 1 Score: 143.28 bits (360), Expect = 6.054e-34 Identity = 134/542 (24.72%), Postives = 231/542 (42.62%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNXXXX----XXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLH--YLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETS------NYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRL-----KQKPSYESIVNEGCAQIGEHMDKYSKSIFIG--KDNRG--LQTFLLLQSTSHVL----------ETMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCC 1884
KS + + V LWI RL E ++ + G ES + + ++Q +TH+ S L L++ YD + D C P Y ++ LR +L+PC II+PL+CFWEGS+LL S ++ ++ W + N + Y ++ S ++ + K A I SG++ KPCL+ + +CP+ Q P +I++ GC + + + +G K NR L+ LQS ++ + K+++L W + K +V+N W + + V + QS+ YVF++ +L+ L + + L + V +L+ + + VR + V L+ + +GLGL A +G FNA +TQVVPF+ +GLG++ + +LT Y+++ N L ++ S A IPVP ++ FC+Q +M ++P ++ LD RR + R D+ CC
Sbjct: 92 LKSAQIHSKVHQLWIQEGGRLEAELAYTQKTIGED-ESATHQLLIQ-TTHDPNASVLHPQALLAHLEVLVKATAVKVHLYDTE-WGLRDMCNMPSTPSFEGIYYIEQILR----HLIPCSIITPLDCFWEGSQLLGPESAVVIPGLNQ----RLLWTTLNPASVMQYMKQKMSEEKISFDFETVEQYMKRAAIGSGYMEKPCLNPLNPNCPDTAPNKNSTQPPDVGAILSGGCYGYAAKHMHWPEELIVGGAKRNRSGHLRKAQALQSVVQLMTEKEMYDQWQDNYKVHHLGWTQEKAAEVLNAWQRNFSREVEQL--------------LRKQSRIATNYDIYVFSSAALDDILAKFSHPSAL--SIVIGVAVTVLYAFCTLLRWRDPVRGQSSVGVAGVLLMCFSTAAGLGLSALLGIVFNAASTQVVPFLALGLGVDHIFMLTAAYAES--------NRREQTKLILKKVGPSILFSACSTAGSFFAAAFIPVPALKVFCLQAAIVMCSNLAAALLVFPAMISLDLRRRTAGRADIFCC 598 HSP 2 Score: 105.531 bits (262), Expect = 2.326e-22 Identity = 99/376 (26.33%), Postives = 174/376 (46.28%), Query Frame = 1
Query: 2287 LYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTK-EFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGE---SINYKKLSTSRLVR-NGKVDERKFYLFLNVWRSMSV-EYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELD-FVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSP 3384
LY++ + GL + P+DSNE ++ +T LF F + VT+ FEY Q +L H + HV +NG FWL F WL +Q FD + ++ L W NAS + +L L+VQ G ++ + + T+RLV +G +++R FY +L+ W + V Y LYP+ P +Y +P+ L + + PL + ++ G + ++ + +R ++ +Y LP P G F EQY+ LR L ++ + + V+ L + A++L L + +S+ M L I L+A V+ + S G+ F++ + + ++ T + Q M++S+ P
Sbjct: 695 LYASTRLQDGLDIIDLVPKDSNEHKFLDAQTRLFGFYSMYAVTQGNFEYPTQQQLLRDYHDSFVRVPHVIKNDNGGLPDFWLLLFSEWLGNLQKIFDEEYRDGR-LTKECWFPNASSDAILAYKLIVQTGHVDNPVDKELVLTNRLVNSDGIINQRAFYNYLSAWATNDVFAYGASQGKLYPE----------PRQYFHQPNEY---DLKIPKSLPLVYAQMPFYLHGLTDTSQIKTLIGHIRDLSVKY-EGFGLPNYPSGIPFIFWEQYMTLRSSLAMILACVLLAALVLVSLLLLSVWAAVLVILSVLASLAQIFGAMTLLGIKLSAIPAVILILSVGMMLCFNVLISLGFM--TSVGNRQRRVQLSMQMSLGP 1053
BLAST of patched-like protein vs. Ensembl Zebrafish
Match: ptch2 (patched 2 [Source:NCBI gene;Acc:30181]) HSP 1 Score: 228.024 bits (580), Expect = 7.370e-60 Identity = 261/1133 (23.04%), Postives = 488/1133 (43.07%), Query Frame = 1
Query: 175 RKSYLMVNMYIKGHSSLKC-KTNIKIWLKLKY----FCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGS---IETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLKQK-----PSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNR-------GLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPD------TFIPNNVHQYCEINPVDLS---PRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCC------WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSP 3384
R SY +K S K +W++ ++ F ++ H K+L IG+ G +G + ETD+ LW+ SR+ E + G + S I+T Q T N L LL L Y + S+ + C + +P + + + ++ L PC I++PL+CFWEGSKL S Y I W + + + + ++ F E+ +A + ++++PCLD +D CP+ K P+ + + GC + + + + +G KD++ LQT LL S + E K I+++ W E K ++ W +K + V+H SIP ++ S+ Y F+ +LN + + + + G ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G++++ +L +++ R I L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCC ++ Q +D+ +++ P FT T +P + LS P ++P S+ F +SS + L + C W + + +++ + V++V + ++ + LY + GL I PRD+ E+ +I + + F F N +VT + F+Y +Q LLQLH +++ +V N K WL F WL+ +Q+ FD D + I + RN +++G L L++Q G E NY +L++ RLV +G + FY++L VW S + Y YP + D + + L + + PL+F ++ G + + + ++ +++VR+I + + P G F EQY+ LR+ ++ +S++LA V ++L +N + A ++ +L ++ M L I L+A V+ + S G+G F++ + + ++ T + +T + ME +P
Sbjct: 36 RPSYCHAAFALKQISKGKAVGQKAPLWIRARFQAFLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVAAIETDIEKLWVEAGSRVSKELRYTKEKQGEESVFTSQMLIQTPKQEGT-NILTQEALLLHLEAALSASKVQVSLYGK-SWDLNKICFKSGVP---IIENVMIERMIDKLFPCMIVTPLDCFWEGSKL------QGGSAYLPGMP-DIQWMNLD-PLKLMEELSQFTSLEGFREMLDKAQVGHAYMNRPCLDPSDTDCPHSAPNKDPWQVPNIAAELQGGCHGFSKKFMHWQEELILGERVKDSQNALQSAEALQTMFLLMSPKQLYEHFKDDYEIHDINWNEDKATAILESWQRKFVE-VVH--------GSIPQNSS---------SNVYAFSTTTLNDIMKSFSDVSVI---RVAGGYLLMLAYACVTMLRWDCAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSFTET----RSNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCCFYSPCSSRVIQIQPQELSDANDNHQRAPATPTYTGSTITTSTHITTTVQAFTQCDAAGQHIVTILPPTSQISTTPPSMVLSTPTPTTDPYGSQVFTTSSSTRDLLAQVEEPKEGRECVPLPFFRWNLSSFAREKYAPLLLKPETKTVVVVVFVALLSLSLYGTTMVHDGLYLTDIVPRDTQEYEFITAQFKYFSFYNMYLVTMDGFDYARSQRQLLQLHNAFNSVKYVVKDGNHKLPRMWLHYFQDWLKGLQATFDADWEAGKITYDSY--RNGTEDGALAYKLLIQTGSKKEPFNYSQLTSRRLVDEDGLIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTG----------ENLRIPAAEPLEFAQFPFYLNGLRQASDFIEAIESVRTICEEFMRQ-GIKNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWTAGVIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHIALGFL--TAIGDRNTRSAVAMEHMFAP 1114
BLAST of patched-like protein vs. Ensembl Zebrafish
Match: ptch2 (patched 2 [Source:NCBI gene;Acc:30181]) HSP 1 Score: 228.024 bits (580), Expect = 8.861e-60 Identity = 246/1069 (23.01%), Postives = 462/1069 (43.22%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGS---IETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLKQK-----PSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNR-------GLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPD------TFIPNNVHQYCEINPVDLS---PRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCC------WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSP 3384
+ ETD+ LW+ SR+ E + G + S I+T Q T N L LL L Y + S+ + C + +P + + + ++ L PC I++PL+CFWEGSKL S Y I W + + + + ++ F E+ +A + ++++PCLD +D CP+ K P+ + + GC + + + + +G KD++ LQT LL S + E K I+++ W E K ++ W +K + V+H SIP ++ S+ Y F+ +LN + + + + G ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G++++ +L +++ R I L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCC ++ Q +D+ +++ P FT T +P + LS P ++P S+ F +SS + L + C W + + +++ + V++V + ++ + LY + GL I PRD+ E+ +I + + F F N +VT + F+Y +Q LLQLH +++ +V N K WL F WL+ +Q+ FD D + I + RN +++G L L++Q G E NY +L++ RLV +G + FY++L VW S + Y YP + D + + L + + PL+F ++ G + + + ++ +++VR+I + + P G F EQY+ LR+ ++ +S++LA V ++L +N + A ++ +L ++ M L I L+A V+ + S G+G F++ + + ++ T + +T + ME +P
Sbjct: 100 LRVAAIETDIEKLWVEAGSRVSKELRYTKEKQGEESVFTSQMLIQTPKQEGT-NILTQEALLLHLEAALSASKVQVSLYGK-SWDLNKICFKSGVP---IIENVMIERMIDKLFPCMIVTPLDCFWEGSKL------QGGSAYLPGMP-DIQWMNLD-PLKLMEELSQFTSLEGFREMLDKAQVGHAYMNRPCLDPSDTDCPHSAPNKDPWQVPNIAAELQGGCHGFSKKFMHWQEELILGERVKDSQNALQSAEALQTMFLLMSPKQLYEHFKDDYEIHDINWNEDKATAILESWQRKFVE-VVH--------GSIPQNSS---------SNVYAFSTTTLNDIMKSFSDVSVI---RVAGGYLLMLAYACVTMLRWDCAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSFTET----RSNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCCFYSPCSSRVIQIQPQELSDANDNHQRAPATPTYTGSTITTSTHITTTVQAFTQCDAAGQHIVTILPPTSQISTTPPSMVLSTPTPTTDPYGSQVFTTSSSTRDLLAQVEEPKEGRECVPLPFFRWNLSSFAREKYAPLLLKPETKTVVVVVFVALLSLSLYGTTMVHDGLYLTDIVPRDTQEYEFITAQFKYFSFYNMYLVTMDGFDYARSQRQLLQLHNAFNSVKYVVKDGNHKLPRMWLHYFQDWLKGLQATFDADWEAGKITYDSY--RNGTEDGALAYKLLIQTGSKKEPFNYSQLTSRRLVDEDGLIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTG----------ENLRIPAAEPLEFAQFPFYLNGLRQASDFIEAIESVRTICEEFMRQ-GIKNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWTAGVIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHIALGFL--TAIGDRNTRSAVAMEHMFAP 1114
BLAST of patched-like protein vs. Ensembl Zebrafish
Match: ptch1 (patched 1 [Source:ZFIN;Acc:ZDB-GENE-980526-196]) HSP 1 Score: 125.561 bits (314), Expect = 2.536e-28 Identity = 128/524 (24.43%), Postives = 225/524 (42.94%), Query Frame = 1
Query: 2281 MGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIP-----KSDHKTR---SPFVRNSDSYRCKSRPSHKSSTKSFRSQVSRNGS 3807
+ LY + GL I PR++ E+ +I+ + F F N +VT+ +Y Q L +LHQ ++ ++ ENG + WL F WL +Q FD+D + I G + RN S +G+L L+VQ G K ++ RLV +G ++ FY++L+ W S V Y + P P I S LN+ + P+++ ++ G + + + ++ +++VR+I + ++ LP+ P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++ + GD NK+ ++ +E F P FST LG+ + ++ F+ R F + + V +LN L P+ Y P +D ++R R RPSH + S S GS
Sbjct: 662 VSLYGTTRVRDGLELTDIVPRETGEYDFIRAQFRYFSFYNMYVVTQRADYAQIQPQLYELHQRFGSVKYILREENGQLPRMWLHYFRDWLLGLQEAFDKDWQAGRI-TQGNY-RNGSDDGVLAYKLLVQTGR--REKTITRQRLVSADGIINPNAFYIYLSAWVSNDPVAYAASQANIRPH---------PPEWLHDRTDSIPASRLNIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAICNNFSRQ-GLPSYPNGYPFLFWEQYVGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVLVLSLMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLT---------------------AIGDR------------------------NKRAVLALEHMF--APVLDGAFSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSYFGPYPEVSPADGQSRLPTPSPEPPPQVVRFTMRPSHTTPGAGSDSSDSEYGS 1123 HSP 2 Score: 115.161 bits (287), Expect = 4.293e-25 Identity = 103/433 (23.79%), Postives = 200/433 (46.19%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETS-NYNFFYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKP-SYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLL 1890
+E L PC +I+PL+CFWEG+KL + + Y + + W +F+ F K + + E+ +A + G++++PCL+ D CP N+ P ++ GC + + + + + +G K++ G QT L + + E +K ++++ W E K ++ W +K + V +S+P + SQ++ FT +L L + + + SG ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R D+ CC +
Sbjct: 89 LEKLHPCLVITPLDCFWEGAKL------HSGTFYLPGKP-PLQWTNFD-PMGFIAELKMLKYQVDSWEEMLVKADVGQGYMNRPCLNPADPDCPLSAPNKNTTGPFDVAPVLTGGCYGLSKKYMHWQEELIVGGTKKNDSGKLLSAQAFQTMFQLMTPKQMYEHLKGYDEVSHINWNEDKAAAILEAWQRKYSEAV---------QQSVPVNS----SQKV-----LTFTTTTLEDILKSFSDVSVI---RIASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFV 484
BLAST of patched-like protein vs. Ensembl Zebrafish
Match: ptch1 (patched 1 [Source:ZFIN;Acc:ZDB-GENE-980526-196]) HSP 1 Score: 125.176 bits (313), Expect = 3.095e-28 Identity = 128/524 (24.43%), Postives = 225/524 (42.94%), Query Frame = 1
Query: 2281 MGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIP-----KSDHKTR---SPFVRNSDSYRCKSRPSHKSSTKSFRSQVSRNGS 3807
+ LY + GL I PR++ E+ +I+ + F F N +VT+ +Y Q L +LHQ ++ ++ ENG + WL F WL +Q FD+D + I G + RN S +G+L L+VQ G K ++ RLV +G ++ FY++L+ W S V Y + P P I S LN+ + P+++ ++ G + + + ++ +++VR+I + ++ LP+ P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++ + GD NK+ ++ +E F P FST LG+ + ++ F+ R F + + V +LN L P+ Y P +D ++R R RPSH + S S GS
Sbjct: 782 VSLYGTTRVRDGLELTDIVPRETGEYDFIRAQFRYFSFYNMYVVTQRADYAQIQPQLYELHQRFGSVKYILREENGQLPRMWLHYFRDWLLGLQEAFDKDWQAGRI-TQGNY-RNGSDDGVLAYKLLVQTGR--REKTITRQRLVSADGIINPNAFYIYLSAWVSNDPVAYAASQANIRPH---------PPEWLHDRTDSIPASRLNIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAICNNFSRQ-GLPSYPNGYPFLFWEQYVGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVLVLSLMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLT---------------------AIGDR------------------------NKRAVLALEHMF--APVLDGAFSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSYFGPYPEVSPADGQSRLPTPSPEPPPQVVRFTMRPSHTTPGAGSDSSDSEYGS 1243 HSP 2 Score: 115.931 bits (289), Expect = 2.365e-25 Identity = 124/545 (22.75%), Postives = 237/545 (43.49%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVST-----HNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRV-QLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETS-NYNFFYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKP-SYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLL 1890
++ ETDV LW+ R++ E + + G E L + T N L ++ Y+R+ +T C + +L + D+ L E L PC +I+PL+CFWEG+KL + + Y + + W +F+ F K + + E+ +A + G++++PCL+ D CP N+ P ++ GC + + + + + +G K++ G QT L + + E +K ++++ W E K ++ W +K + V +S+P + SQ++ FT +L L + + + SG ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R D+ CC +
Sbjct: 105 LRAANLETDVEKLWVEVGGRVNQELKYTRQKIG---EEAMFSPQLMIQTPRQEGANILTVEALKQHLDSAIKASRVHVYMYNRQ-WTLEHLCYKSGELVTETNVVDQIL----EKLHPCLVITPLDCFWEGAKL------HSGTFYLPGKP-PLQWTNFD-PMGFIAELKMLKYQVDSWEEMLVKADVGQGYMNRPCLNPADPDCPLSAPNKNTTGPFDVAPVLTGGCYGLSKKYMHWQEELIVGGTKKNDSGKLLSAQAFQTMFQLMTPKQMYEHLKGYDEVSHINWNEDKAAAILEAWQRKYSEAV---------QQSVPVNS----SQKV-----LTFTTTTLEDILKSFSDVSVI---RIASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFV 604
BLAST of patched-like protein vs. Ensembl Zebrafish
Match: ptch1 (patched 1 [Source:ZFIN;Acc:ZDB-GENE-980526-196]) HSP 1 Score: 123.635 bits (309), Expect = 1.011e-27 Identity = 95/353 (26.91%), Postives = 174/353 (49.29%), Query Frame = 1
Query: 2281 MGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+ LY + GL I PR++ E+ +I+ + F F N +VT+ +Y Q L +LHQ ++ ++ ENG + WL F WL +Q FD+D + I G + RN + +G+L L+VQ G K ++ RLV +G ++ FY++L+ W S V Y + P P I S LN+ + P+++ ++ G + + + ++ +++VR+I + Y+ LP+ P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 782 VSLYGTTRVRDGLELTDIVPRETGEYDFIRAQFRYFSFYNMYVVTQRADYAQIQPQLYELHQRFGSVKYILREENGQLPRMWLHYFRDWLLGLQEAFDKDWQAGRI-TQGNY-RNGTDDGVLAYKLLVQTGR--REKTITRQRLVSADGIINPNAFYIYLSAWVSNDPVAYAASQANIRPH---------PPEWLHDRTDSIPASRLNIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAICNNYSRQ-GLPSYPNGYPFLFWEQYVGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVLVLSLMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1119 HSP 2 Score: 115.546 bits (288), Expect = 2.806e-25 Identity = 124/545 (22.75%), Postives = 237/545 (43.49%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVST-----HNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRV-QLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETS-NYNFFYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKP-SYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLL 1890
++ ETDV LW+ R++ E + + G E L + T N L ++ Y+R+ +T C + +L + D+ L E L PC +I+PL+CFWEG+KL + + Y + + W +F+ F K + + E+ +A + G++++PCL+ D CP N+ P ++ GC + + + + + +G K++ G QT L + + E +K ++++ W E K ++ W +K + V +S+P + SQ++ FT +L L + + + SG ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R D+ CC +
Sbjct: 105 LRAANLETDVEKLWVEVGGRVNQELKYTRQKIG---EEAMFSPQLMIQTPRQEGANILTVEALKQHLDSAIKASRVHVYMYNRQ-WTLEHLCYKSGELVTETNVVDQIL----EKLHPCLVITPLDCFWEGAKL------HSGTFYLPGKP-PLQWTNFD-PMGFIAELKMLKYQVDSWEEMLVKADVGQGYMNRPCLNPADPDCPLSAPNKNTTGPFDVAPVLTGGCYGLSKKYMHWQEELIVGGTKKNDSGKLLSAQAFQTMFQLMTPKQMYEHLKGYDEVSHINWNEDKAAAILEAWQRKYSEAV---------QQSVPVNS----SQKV-----LTFTTTTLEDILKSFSDVSVI---RIASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFV 604
BLAST of patched-like protein vs. Ensembl Xenopus
Match: PTCH2 (patched 2 [Source:NCBI gene;Acc:100492958]) HSP 1 Score: 235.728 bits (600), Expect = 1.760e-62 Identity = 236/1037 (22.76%), Postives = 456/1037 (43.97%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQV---STHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPN-----RLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG----------KDNRGLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHP--HPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL-------LKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCC------WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLEN---GKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQ-LVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+ ETD+ LW+ SR+ +E + G + S + ++Q N L LL L Y + S+ + C + +P + + + +E L PC II+PL+CFWEGS+L S Y R+ I W + + Q + ++ + F E+ +A + ++ +PCLD TD+ CP + K+ P S + GC + + K + +G K LQT LL S + E K I+++ W E K ++ W +K + +SIP + SQ I S + + + A + + G ++ML + + + +S + + L+ ++ SGLGL + +G +FNA TTQV+PF+ +G+G++++ +L +++ ++ P + L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCC + + P + ++ + V C +++ + + +++ +T+P +P +P S+ F +SS + L ++ C W + + +++ + V+ + + ++ +GLY + GL I PR++ E+++I + + F F N IVTK+ F+Y Q+ L LH+ ++ +V E K WL F WL +Q+ FD+D + I + RN +++ +L L++Q G E N+ +L++ RLV G + + FY++L VW S + Y YP+ + D + + L + + P++F ++ G + + + ++ +++VRS+ + + + P G F EQY+ LR+ L+ +SI+LA V ++L +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + + ++
Sbjct: 98 LRVASIETDIERLWVEAGSRVSHELRYTKEKLGEESVYTS-QMLIQTPKREGENILTQEALLLHLRAALAASKVQVSMYGK-SWDLNKICYKSGVP---IIENGMIERMIEKLFPCVIITPLDCFWEGSQL------QGGSAYLPGRA-DIQWTNLDPIQ-LMEELGQFTSLDGFKEMLDKAEVGQAYMERPCLDPTDSDCPESSPNKKTKKNPDIVSTLRRGCYGFSKKFMYWQKELILGGMLKGPDGELKSAEALQTMYLLMSPGQLYEHFKDDYEIHDINWNEEKAAAILESWQRKFVEQA---------QQSIPQNS----SQDIHAFSTTTLNDIMKSFSDVSAIR--------VAGGYLLMLAYACVTMLRWDCSKSQGAVGLAGVLLVALSVASGLGLCSLLGISFNAATTQVLPFLALGIGVDDMFLLAHAFTET------SLSTPFKERTGECLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDQRLDILCCFYSPCSSRVIQIQPQEFSDITTTVQAFTQCDPSGHHIV-TILPPTSQISTSPSVIVPT----------------MDPLGSQVFSPSSSTRDLLAQLDESKEKRECVPLPFLKWSLSDFAREKYAPVLLKAETKGIVVALFMALLGLGLYGTTMVHDGLYLTDIVPRETKEYNFISAQFKYFSFYNMFIVTKDGFDYPKAQESLYDLHEAFGSVKYVVREEGRDLPKMWLHYFQDWLRGLQTAFDKDWELGHITEDSY--RNGTEDSVLAFKLLIQTGNKKEPFNFNQLTSRRLVDEKGLIPQDAFYIYLTVWVSNDPLGYAASQANFYPQPPEWIHDRYDTTG----------ENLRIPAAEPIEFAQFPFYLNGLRQTSDFIEAIESVRSVCEEFVKQ-GVQSYPSGYPFLFWEQYIGLRHWFLLAISIVLACTFLVCAILLLNPWTAGIIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHVALGFL 1063
BLAST of patched-like protein vs. Ensembl Xenopus
Match: PTCH2 (patched 2 [Source:NCBI gene;Acc:100492958]) HSP 1 Score: 234.958 bits (598), Expect = 2.804e-62 Identity = 240/1046 (22.94%), Postives = 458/1046 (43.79%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQV---STHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPN-----RLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG----------KDNRGLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHP--HPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPD------TFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCC------WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLEN---GKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQ-LVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+ ETD+ LW+ SR+ +E + G + S + ++Q N L LL L Y + S+ + C + +P + + + +E L PC II+PL+CFWEGS+L S Y R+ I W + + Q + ++ + F E+ +A + ++ +PCLD TD+ CP + K+ P S + GC + + K + +G K LQT LL S + E K I+++ W E K ++ W +K + +SIP + SQ I S + + + A + + G ++ML + + + +S + + L+ ++ SGLGL + +G +FNA TTQV+PF+ +G+G++++ +L +++ ++ P + L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCC ++ Q +D+ ++++ P Y ++ + + FT T +P +P + P +P S+ F +SS + L ++ C W + + +++ + V+ + + ++ +GLY + GL I PR++ E+++I + + F F N IVTK+ F+Y Q+ L LH+ ++ +V E K WL F WL +Q+ FD+D + I + RN +++ +L L++Q G E N+ +L++ RLV G + + FY++L VW S + Y YP+ + D + + L + + P++F ++ G + + + ++ +++VRS+ + + + P G F EQY+ LR+ L+ +SI+LA V ++L +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + + ++
Sbjct: 98 LRVASIETDIERLWVEAGSRVSHELRYTKEKLGEESVYTS-QMLIQTPKREGENILTQEALLLHLRAALAASKVQVSMYGK-SWDLNKICYKSGVP---IIENGMIERMIEKLFPCVIITPLDCFWEGSQL------QGGSAYLPGRA-DIQWTNLDPIQ-LMEELGQFTSLDGFKEMLDKAEVGQAYMERPCLDPTDSDCPESSPNKKTKKNPDIVSTLRRGCYGFSKKFMYWQKELILGGMLKGPDGELKSAEALQTMYLLMSPGQLYEHFKDDYEIHDINWNEEKAAAILESWQRKFVEQA---------QQSIPQNS----SQDIHAFSTTTLNDIMKSFSDVSAIR--------VAGGYLLMLAYACVTMLRWDCSKSQGAVGLAGVLLVALSVASGLGLCSLLGISFNAATTQVLPFLALGIGVDDMFLLAHAFTET------SLSTPFKERTGECLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDQRLDILCCFYSPCSSRVIQIQPQEFSDANDNHTYHPSSYGNPTITTSTQITTTV--QAFTQCDPSGHHIVTILPPTSQ--ISTSPSVIVPTMDPLGSQVFSPSSSTRDLLAQLDESKEKRECVPLPFLKWSLSDFAREKYAPVLLKAETKGIVVALFMALLGLGLYGTTMVHDGLYLTDIVPRETKEYNFISAQFKYFSFYNMFIVTKDGFDYPKAQESLYDLHEAFGSVKYVVREEGRDLPKMWLHYFQDWLRGLQTAFDKDWELGHITEDSY--RNGTEDSVLAFKLLIQTGNKKEPFNFNQLTSRRLVDEKGLIPQDAFYIYLTVWVSNDPLGYAASQANFYPQPPEWIHDRYDTTG----------ENLRIPAAEPIEFAQFPFYLNGLRQTSDFIEAIESVRSVCEEFVKQ-GVQSYPSGYPFLFWEQYIGLRHWFLLAISIVLACTFLVCAILLLNPWTAGIIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHVALGFL 1085
BLAST of patched-like protein vs. Ensembl Xenopus
Match: PTCH2 (patched 2 [Source:NCBI gene;Acc:100492958]) HSP 1 Score: 234.958 bits (598), Expect = 2.975e-62 Identity = 250/1080 (23.15%), Postives = 472/1080 (43.70%), Query Frame = 1
Query: 250 WLKLKYFCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQV---STHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPN-----RLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG----------KDNRGLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHP--HPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPD------TFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCC------WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLEN---GKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQ-LVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
W K F ++ H K+L IG+ G +G + ETD+ LW+ SR+ +E + G + S + ++Q N L LL L Y + S+ + C + +P + + + +E L PC II+PL+CFWEGS+L S Y + I W + + Q + ++ + F E+ +A + ++ +PCLD TD+ CP + K+ P S + GC + + K + +G K LQT LL S + E K I+++ W E K ++ W R ++ESIP + SQ I S + + + A + + G ++ML + + + +S + + L+ ++ SGLGL + +G +FNA TTQV+PF+ +G+G++++ +L +++ ++ P + L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCC ++ Q +D+ ++++ P Y ++ + + FT T +P +P + P +P S+ F +SS + L ++ C W + + +++ + V+ + + ++ +GLY + GL I PR++ E+++I + + F F N IVTK+ F+Y Q+ L LH+ ++ +V E K WL F WL +Q+ FD+D + I + RN +++ +L L++Q G E N+ +L++ RLV G + + FY++L VW S + Y YP+ + D + + L + + P++F ++ G + + + ++ +++VRS+ + + + P G F EQY+ LR+ L+ +SI+LA V ++L +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + + ++
Sbjct: 19 WPKALLFSLGCSIQRHCGKVLFIGLLVFGALAVGLRVASIETDIERLWVEAGSRVSHELRYTKEKLGEESVYTS-QMLIQTPKREGENILTQEALLLHLRAALAASKVQVSMYGK-SWDLNKICYKSGVP---IIENGMIERMIEKLFPCVIITPLDCFWEGSQL------QGGSAYLPA---DIQWTNLDPIQ-LMEELGQFTSLDGFKEMLDKAEVGQAYMERPCLDPTDSDCPESSPNKKTKKNPDIVSTLRRGCYGFSKKFMYWQKELILGGMLKGPDGELKSAEALQTMYLLMSPGQLYEHFKDDYEIHDINWNEEKAAAILESW-------------QRKFVESIPQNS----SQDIHAFSTTTLNDIMKSFSDVSAIR--------VAGGYLLMLAYACVTMLRWDCSKSQGAVGLAGVLLVALSVASGLGLCSLLGISFNAATTQVLPFLALGIGVDDMFLLAHAFTET------SLSTPFKERTGECLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDQRLDILCCFYSPCSSRVIQIQPQEFSDANDNHTYHPSSYGNPTITTSTQITTTV--QAFTQCDPSGHHIVTILPPTSQ--ISTSPSVIVPTMDPLGSQVFSPSSSTRDLLAQLDESKEKRECVPLPFLKWSLSDFAREKYAPVLLKAETKGIVVALFMALLGLGLYGTTMVHDGLYLTDIVPRETKEYNFISAQFKYFSFYNMFIVTKDGFDYPKAQESLYDLHEAFGSVKYVVREEGRDLPKMWLHYFQDWLRGLQTAFDKDWELGHITEDSY--RNGTEDSVLAFKLLIQTGNKKEPFNFNQLTSRRLVDEKGLIPQDAFYIYLTVWVSNDPLGYAASQANFYPQPPEWIHDRYDTTG----------ENLRIPAAEPIEFAQFPFYLNGLRQTSDFIEAIESVRSVCEEFVKQ-GVQSYPSGYPFLFWEQYIGLRHWFLLAISIVLACTFLVCAILLLNPWTAGIIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHVALGFL 1034
BLAST of patched-like protein vs. Ensembl Xenopus
Match: PTCH2 (patched 2 [Source:NCBI gene;Acc:100492958]) HSP 1 Score: 234.187 bits (596), Expect = 4.978e-62 Identity = 240/1046 (22.94%), Postives = 458/1046 (43.79%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQV---STHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPN-----RLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG----------KDNRGLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHP--HPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPD------TFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCC------WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLEN---GKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQ-LVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+ ETD+ LW+ SR+ +E + G + S + ++Q N L LL L Y + S+ + C + +P + + + +E L PC II+PL+CFWEGS+L S Y R+ I W + + Q + ++ + F E+ +A + ++ +PCLD TD+ CP + K+ P S + GC + + K + +G K LQT LL S + E K I+++ W E K ++ W +K + +SIP + SQ I S + + + A + + G ++ML + + + +S + + L+ ++ SGLGL + +G +FNA TTQV+PF+ +G+G++++ +L +++ ++ P + L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCC ++ Q +D+ ++++ P Y ++ + + FT T +P +P + P +P S+ F +SS + L ++ C W + + +++ + V+ + + ++ +GLY + GL I PR++ E+++I + + F F N IVTK+ F+Y Q+ L LH+ ++ +V E K WL F WL +Q+ FD+D + I + RN +++ +L L++Q G E N+ +L++ RLV G + + FY++L VW S + Y YP+ + D + + L + + P++F ++ G + + + ++ +++VRS+ + + + P G F EQY+ LR+ L+ +SI+LA V ++L +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + + ++
Sbjct: 98 LRVASIETDIERLWVEAGSRVSHELRYTKEKLGEESVYTS-QMLIQTPKREGENILTQEALLLHLRAALAASKVQVSMYGK-SWDLNKICYKSGVP---IIENGMIERMIEKLFPCVIITPLDCFWEGSQL------QGGSAYLPGRA-DIQWTNLDPIQ-LMEELGQFTSLDGFKEMLDKAEVGQAYMERPCLDPTDSDCPESSPNKKTKKNPDIVSTLRRGCYGFSKKFMYWQKELILGGMLKGPDGELKSAEALQTMYLLMSPGQLYEHFKDDYEIHDINWNEEKAAAILESWQRKFVEQA---------QQSIPQNS----SQDIHAFSTTTLNDIMKSFSDVSAIR--------VAGGYLLMLAYACVTMLRWDCSKSQGAVGLAGVLLVALSVASGLGLCSLLGISFNAATTQVLPFLALGIGVDDMFLLAHAFTET------SLSTPFKERTGECLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDQRLDILCCFYSPCSSRVIQIQPQEFSDANDNHTYHPSSYGNPTITTSTQITTTV--QAFTQCDPSGHHIVTILPPTSQ--ISTSPSVIVPTMDPLGSQVFSPSSSTRDLLAQLDESKEKRECVPLPFLKWSLSDFAREKYAPVLLKAETKGIVVALFMALLGLGLYGTTMVHDGLYLTDIVPRETKEYNFISAQFKYFSFYNMFIVTKDGFDYPKAQESLYDLHEAFGSVKYVVREEGRDLPKMWLHYFQDWLRGLQTAFDKDWELGHITEDSY--RNGTEDSVLAFKLLIQTGNKKEPFNFNQLTSRRLVDEKGLIPQDAFYIYLTVWVSNDPLGYAASQANFYPQPPEWIHDRYDTTG----------ENLRIPAAEPIEFAQFPFYLNGLRQTSDFIEAIESVRSVCEEFVKQ-GVQSYPSGYPFLFWEQYIGLRHWFLLAISIVLACTFLVCAILLLNPWTAGIIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHVALGFL 1085
BLAST of patched-like protein vs. Ensembl Xenopus
Match: PTCH2 (patched 2 [Source:NCBI gene;Acc:100492958]) HSP 1 Score: 235.343 bits (599), Expect = 6.000e-62 Identity = 241/1048 (23.00%), Postives = 456/1048 (43.51%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQV---STHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPN-----RLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG----------KDNRGLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHP--HPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVH--------QYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCC------WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLEN---GKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQ-LVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+ ETD+ LW+ SR+ +E + G + S + ++Q N L LL L Y + S+ + C + +P + + + +E L PC II+PL+CFWEGS+L S Y R+ I W + + Q + ++ + F E+ +A + ++ +PCLD TD+ CP + K+ P S + GC + + K + +G K LQT LL S + E K I+++ W E K ++ W +K + +SIP + SQ I S + + + A + + G ++ML + + + +S + + L+ ++ SGLGL + +G +FNA TTQV+PF+ +G+G++++ +L +++ ++ P + L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCC ++ Q +D+ ++++ P Y N + T A P+ H +P + P +P S+ F +SS + L ++ C W + + +++ + V+ + + ++ +GLY + GL I PR++ E+++I + + F F N IVTK+ F+Y Q+ L LH+ ++ +V E K WL F WL +Q+ FD+D + I + RN +++ +L L++Q G E N+ +L++ RLV G + + FY++L VW S + Y YP+ + D + + L + + P++F ++ G + + + ++ +++VRS+ + + + P G F EQY+ LR+ L+ +SI+LA V ++L +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + + ++
Sbjct: 98 LRVASIETDIERLWVEAGSRVSHELRYTKEKLGEESVYTS-QMLIQTPKREGENILTQEALLLHLRAALAASKVQVSMYGK-SWDLNKICYKSGVP---IIENGMIERMIEKLFPCVIITPLDCFWEGSQL------QGGSAYLPGRA-DIQWTNLDPIQ-LMEELGQFTSLDGFKEMLDKAEVGQAYMERPCLDPTDSDCPESSPNKKTKKNPDIVSTLRRGCYGFSKKFMYWQKELILGGMLKGPDGELKSAEALQTMYLLMSPGQLYEHFKDDYEIHDINWNEEKAAAILESWQRKFVEQA---------QQSIPQNS----SQDIHAFSTTTLNDIMKSFSDVSAIR--------VAGGYLLMLAYACVTMLRWDCSKSQGAVGLAGVLLVALSVASGLGLCSLLGISFNAATTQVLPFLALGIGVDDMFLLAHAFTET------SLSTPFKERTGECLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDQRLDILCCFYSPCSSRVIQIQPQEFSDANDNHTYHPSSY------GNPTITTSTQITTTVQAFTQCDPSGHHIVTILPPTSQISTSPSVIVPTMDPLGSQVFSPSSSTRDLLAQLDESKEKRECVPLPFLKWSLSDFAREKYAPVLLKAETKGIVVALFMALLGLGLYGTTMVHDGLYLTDIVPRETKEYNFISAQFKYFSFYNMFIVTKDGFDYPKAQESLYDLHEAFGSVKYVVREEGRDLPKMWLHYFQDWLRGLQTAFDKDWELGHITEDSY--RNGTEDSVLAFKLLIQTGNKKEPFNFNQLTSRRLVDEKGLIPQDAFYIYLTVWVSNDPLGYAASQANFYPQPPEWIHDRYDTTG----------ENLRIPAAEPIEFAQFPFYLNGLRQTSDFIEAIESVRSVCEEFVKQ-GVQSYPSGYPFLFWEQYIGLRHWFLLAISIVLACTFLVCAILLLNPWTAGIIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHVALGFL 1085
BLAST of patched-like protein vs. Ensembl Mouse
Match: Ptch1 (patched 1 [Source:MGI Symbol;Acc:MGI:105373]) HSP 1 Score: 219.935 bits (559), Expect = 2.010e-57 Identity = 237/946 (25.05%), Postives = 431/946 (45.56%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCPNRLKQKPSYES-----IVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLK-------RQTPNDSTESYS----AVPRQYDC---VRKDSNLLKSKIIFSTEFTTAPDT---FIPNNVHQYCEINPV-----DLSPRSEPSTSRSFPLNSSVDNN----LEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP K S + ++N GC + + + + +G K+ G LQT L + + E + ++++ W E + ++ W R Y+E + A +Q++ FT +L+ L + + + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC + P TE +S + P Y + ++S + TE+ P T + + PV +LS +S STS + L S ++ LEP K W K + ++ ++ VIL+ L ++ + LY + GL I PR++ E+ +I + + F F N IVT++ +Y N Q +L LH+ N+ +V L EN + WL F WL+ +Q FD D + I+ N +N S +G+L L+VQ G + I+ +L+ RLV +G ++ FY++L W S V Y + P + D + Y E + L + + P+++ ++ G + + + ++ ++ VR I + YT +L L + P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 69 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILEAW-------------QRTYVEVVHQSVAPNSTQKVLP-----FTTTTLDDILKSFSDVSVI---RVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTEPHSNTRYSPPPPYTSHSFAHETHITMQSTVQLRTEYD--PHTHVYYTTAEPRSEISVQPVTVTQDNLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK-------WTLSSFAEKHYAPFLLKPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSNVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNY--KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDK---ADYMPE------TRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYT-SLGLSSYPNGYPFLFWEQYISLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 954
BLAST of patched-like protein vs. Ensembl Mouse
Match: Ptch1 (patched 1 [Source:MGI Symbol;Acc:MGI:105373]) HSP 1 Score: 219.55 bits (558), Expect = 3.904e-57 Identity = 237/946 (25.05%), Postives = 431/946 (45.56%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCPNRLKQKPSYES-----IVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLK-------RQTPNDSTESYS----AVPRQYDC---VRKDSNLLKSKIIFSTEFTTAPDT---FIPNNVHQYCEINPV-----DLSPRSEPSTSRSFPLNSSVDNN----LEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP K S + ++N GC + + + + +G K+ G LQT L + + E + ++++ W E + ++ W R Y+E + A +Q++ FT +L+ L + + + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC + P TE +S + P Y + ++S + TE+ P T + + PV +LS +S STS + L S ++ LEP K W K + ++ ++ VIL+ L ++ + LY + GL I PR++ E+ +I + + F F N IVT++ +Y N Q +L LH+ N+ +V L EN + WL F WL+ +Q FD D + I+ N +N S +G+L L+VQ G + I+ +L+ RLV +G ++ FY++L W S V Y + P + D + Y E + L + + P+++ ++ G + + + ++ ++ VR I + YT +L L + P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 206 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILEAW-------------QRTYVEVVHQSVAPNSTQKVLP-----FTTTTLDDILKSFSDVSVI---RVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTEPHSNTRYSPPPPYTSHSFAHETHITMQSTVQLRTEYD--PHTHVYYTTAEPRSEISVQPVTVTQDNLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK-------WTLSSFAEKHYAPFLLKPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSNVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNY--KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDK---ADYMPE------TRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYT-SLGLSSYPNGYPFLFWEQYISLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1091
BLAST of patched-like protein vs. Ensembl Mouse
Match: Ptch2 (patched 2 [Source:MGI Symbol;Acc:MGI:1095405]) HSP 1 Score: 210.69 bits (535), Expect = 1.098e-54 Identity = 241/1029 (23.42%), Postives = 429/1029 (41.69%), Query Frame = 1
Query: 367 FETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTH----NXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCP----NR-LKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLL----LQST----------SHVLETMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYD--CVRKDSNLLKSKIIFSTEFTTAPD---TFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRC----C--WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHV---ALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYT--NNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
ETD+ LW+ SR+ E + G E+ +L + H N L L L Y + S+ + C + +P + + + +E L PC I++PL+CFWEG+KL S Y R I W + + Q+ ++ F EL +A + ++ +PCLD D CP NR +Q P+ ++ GC + + + +G R LQ LL LQST H + +++ W E + V+ W ++ Q E++P NA SQ+I + F++ +L+ L ++ T + G ++ML + + + +S + + L+ A+ SGLGL A +G TFNA TTQV+PF+ +G+G++++ +L ++K P + + L T + ++ ++ ++P+P +R F +Q ++ ++P +L LD RR R+D+LCC +P S + +P++ V L + + T + T +P H LSP S+P S + S + L + + C C W + F +++ + V+L ++ + LY A + GL + PR + E ++ + F +VT+ F+Y ++Q L LHQ +L V + + WL + WL+ IQ+ FD+D + I + RN S++G L L++Q G E +++ +L+T +LV + G + FY+ L VW S + YP + D + + L + + PL+F + G Q+ DFV+ + + T + P G+ F EQYL LR ++ IL + F++ L + + L L+L+ + M I L+A V+ + S G+G F++ + + ++
Sbjct: 78 IETDLEQLWVEVGSRVSQELHYTKEKLGE--EAAYTSQMLIQTAHQEGGNVLTPEALDLHLQAALTASKVQVSLYGK-SWDLNKICYKSGVP---LIENGMIERMIEKLFPCVILTPLDCFWEGAKL------QGGSAYLPGRP-DIQWTNLD-PQQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLDPDDPHCPPSAPNRHSRQAPNVAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASMVLQAWQRRFVQLA---------QEALP-ANA---SQQI-----HAFSSTTLDDILRAFSEVST---TRVVGGYLLMLAYACVTMLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAFTK----APPDTPLPERMGECLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCF---SSPC-SAQVIQMLPQELGDRAVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHL--------LSPASDPLGSELYSPGGSTRDLLSQEEGTGPQAACRPLLCAHWTLAHFARYQFAPLLLQTRAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRSWLQGIQAAFDQDWASGRITCHSY--RNGSEDGALAYKLLIQTGNAQEPLDFSQLTTRKLVDKEGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTG----------ENLRIPAAQPLEFAQFPFLLHGL--QKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLSPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASIGIGVEFTVHVALGFL 1041
BLAST of patched-like protein vs. Ensembl Mouse
Match: Ptch1 (patched 1 [Source:MGI Symbol;Acc:MGI:105373]) HSP 1 Score: 116.316 bits (290), Expect = 3.911e-26 Identity = 108/432 (25.00%), Postives = 199/432 (46.06%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKP-SYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCC 1884
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP N+ KP ++N GC + + + + +G K+ G LQT L + + E + ++++ W E + ++ W R Y+E + A +Q++ FT +L+ L + + + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC
Sbjct: 154 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILEAW-------------QRTYVEVVHQSVAPNSTQKVLP-----FTTTTLDDILKSFSDVSVI---RVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 547
BLAST of patched-like protein vs. Ensembl Mouse
Match: Ptch2 (patched 2 [Source:MGI Symbol;Acc:MGI:1095405]) HSP 1 Score: 80.4925 bits (197), Expect = 2.056e-15 Identity = 64/255 (25.10%), Postives = 103/255 (40.39%), Query Frame = 1
Query: 367 FETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTH----NXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASC----PNR-LKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLLLQSTSHV 1104
ETD+ LW+ SR+ E + G E+ +L + H N L L L Y + S+ + C + +P + + + +E L PC I++PL+CFWEG+KL S Y R I W + + Q+ ++ F EL +A + ++ +PCLD D C PNR +Q P+ ++ GC + + + +G R LQ LL H+
Sbjct: 78 IETDLEQLWVEVGSRVSQELHYTKEKLGE--EAAYTSQMLIQTAHQEGGNVLTPEALDLHLQAALTASKVQVSLYGK-SWDLNKICYKSGVP---LIENGMIERMIEKLFPCVILTPLDCFWEGAKL------QGGSAYLPGRP-DIQWTNLD-PQQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLDPDDPHCPPSAPNRHSRQAPNVAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRGLAEHL 318
BLAST of patched-like protein vs. UniProt/SwissProt
Match: sp|Q98864|PTC1_DANRE (Protein patched homolog 1 OS=Danio rerio OX=7955 GN=ptch1 PE=2 SV=1) HSP 1 Score: 222.246 bits (565), Expect = 2.023e-57 Identity = 259/1139 (22.74%), Postives = 483/1139 (42.41%), Query Frame = 1
Query: 175 RKSYLMVNMYIKGHSSLKC-KTNIKIWLKLKY----FCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGS---IETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLKQK-----PSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNR-------GLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPD------TFIPNNVHQYCEINPVDLS---PRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCC------WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPML------FMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSP 3384
R SY +K S K +W++ ++ F ++ H K+L IG+ G +G + ETD+ LW+ SR+ E + G + S I+T Q T N L LL L Y + S+ + C + +P + + + ++ L PC I++PL+CFWEGSKL S Y I W + + + + ++ F E+ +A + ++++PCLD +D CP+ K P+ + + GC + + + + +G KD++ LQT LL S + E K I+++ W E K ++ W +K + V+H SIP ++ S+ Y F+ +LN + + + + G ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+P + +G+G++++ +L +++ R I L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCC ++ Q +D+ +++ P FT T +P + LS P ++P S+ F +SS + L + C W + + +++ + V++V + ++ + LY + GL I PRD+ E+ +I + + F F N +VT + F+Y +Q LLQLH +++ +V N K WL F WL+ +Q+ FD D + I + RN +++G L ++Q G E NY +L++ RLV +G + FY++L VW S + Y YP + D + + L + + PL+F ++ G + + + ++ +++VR+I + + P G F EQY+ LR+ ++ +S++LA V ++L +N + + PM+ M L I L+A V+ + S G+G F++ + + ++ T + +T + ME +P
Sbjct: 36 RPSYCHAAFALKQISKGKAVGQKAPLWIRARFQAFLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVAAIETDIEKLWVEAGSRVSKELRYTKEKQGEESVFTSQMLIQTPKQEGT-NILTQEALLLHLEAALSASKVQVSLYGK-SWDLNKICFKSGVP---IIENVMIERMIDKLFPCMIVTPLDCFWEGSKL------QGGSAYLPGMP-DIQWMNLD-PLKLMEELSQFTSLEGFREMLDKAQVGHAYMNRPCLDPSDTDCPHSAPNKDPWQVPNIAAELQGGCHGFSKKFMHWQEELILGERVKDSQNALQSAEALQTMFLLMSPKQLYEHFKDDYEIHDINWNEDKATAILESWQRKFVE-VVH--------GSIPQNSS---------SNVYAFSTTTLNDIMKSFSDVSVI---RVAGGYLLMLAYACVTMLRWDCAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPSLALGIGVDDMFLLGHSFTET----RSNIPFKERTGDCLRRTGTSVALTSVNNMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMALLIFPAILSLDLHRREDKRLDILCCFYSPCSSRVIQIQPQELSDANDNHQRAPATPTYTGSTITTSTHITTTVQAFTQCDAAGQHIVTILPPTSQISTTPPSMVLSTPTPTTDPYGSQVFTTSSSTRDLLAQVEEPKEGRECVPLPFFRWNLSSFAREKYAPLLLKPETKTVVVVVFVALLSLSLYGTTMVHDGLYLTDIVPRDTQEYEFITAQFKYFSFYNMYLVTMDGFDYARSQRQLLQLHNAFNSVKYVVKDGNHKLPRMWLHYFQDWLKGLQATFDADWEAGKITYDSY--RNGTEDGALAYKPLIQTGSKKEPFNYSQLTSRRLVDGDGLIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTG----------ENLRIPAAEPLEFAQFPFYLNGLRQASDFIEAIESVRTICEEFMRQ-GIKNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLNPW-------TAGVIVFILPMMTVELFGIMGLIGIKLSAIPVVILIASVGIGVEFTVHIALGFL--TAIGDRNTRSAVAMEHMFAP 1114
BLAST of patched-like protein vs. UniProt/SwissProt
Match: sp|Q13635|PTC1_HUMAN (Protein patched homolog 1 OS=Homo sapiens OX=9606 GN=PTCH1 PE=1 SV=2) HSP 1 Score: 221.476 bits (563), Expect = 6.695e-57 Identity = 238/948 (25.11%), Postives = 428/948 (45.15%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKPSYESIV-NEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINP------VDLSPRSE------------------PSTSRSFPLNSSVDNN----LEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP N+ KP ++V N GC + + + + +G K++ G LQT L + + E K ++++ W E K ++ W R Y+E + A+ +Q++ SF T + + + D +++ + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC T + P+ Y ++ S F + + V E +P PRSE STS + L S ++ LEP K W K + ++ ++ VI + L ++ + LY + GL I PR++ E+ +I + + F F N IVT++ +Y N Q +L LH+ N+ +V L EN K WL F WL+ +Q FD D + I+ N +N S +G+L L+VQ G + I+ +L+ RLV +G ++ FY++L W S V Y + P + D + Y E + L + + P+++ ++ G + + + ++ ++ VR+I S YT +L L + P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 220 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAW-------------QRTYVEVVHQSVAQNSTQKVL--SFTTTTLDDILKSF----SDVSVIR--VASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCF----TSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK-------WTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNY--KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDK---ADYMPE------TRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1105
BLAST of patched-like protein vs. UniProt/SwissProt
Match: sp|Q61115|PTC1_MOUSE (Protein patched homolog 1 OS=Mus musculus OX=10090 GN=Ptch1 PE=1 SV=1) HSP 1 Score: 219.55 bits (558), Expect = 2.731e-56 Identity = 237/946 (25.05%), Postives = 431/946 (45.56%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNF--FYELFKEAGIKSGFISKPCLDVTDASCPNRLKQKPSYES-----IVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLK-------RQTPNDSTESYS----AVPRQYDC---VRKDSNLLKSKIIFSTEFTTAPDT---FIPNNVHQYCEINPV-----DLSPRSEPSTSRSFPLNSSVDNN----LEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+E L PC II+PL+CFWEG+KL + Y + + W +F+ EF K+ NY + E+ +A + G++ +PCL+ D CP K S + ++N GC + + + + +G K+ G LQT L + + E + ++++ W E + ++ W R Y+E + A +Q++ FT +L+ L + + + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R+D+ CC + P TE +S + P Y + ++S + TE+ P T + + PV +LS +S STS + L S ++ LEP K W K + ++ ++ VIL+ L ++ + LY + GL I PR++ E+ +I + + F F N IVT++ +Y N Q +L LH+ N+ +V L EN + WL F WL+ +Q FD D + I+ N +N S +G+L L+VQ G + I+ +L+ RLV +G ++ FY++L W S V Y + P + D + Y E + L + + P+++ ++ G + + + ++ ++ VR I + YT +L L + P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 206 IEYLYPCLIITPLDCFWEGAKL------QSGTAYLLGKP-PLRWTNFD-PLEFLEELKKI-NYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDVALVLNGGCQGLSRKYMHWQEELIVGGTVKNATGKLVSAHALQTMFQLMTPKQMYEHFRGYDYVSHINWNEDRAAAILEAW-------------QRTYVEVVHQSVAPNSTQKVLP-----FTTTTLDDILKSFSDVSVI---RVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTEPHSNTRYSPPPPYTSHSFAHETHITMQSTVQLRTEYD--PHTHVYYTTAEPRSEISVQPVTVTQDNLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTK-------WTLSSFAEKHYAPFLLKPKAKVVVILLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHKSFSNVKYVMLEENKQLPQMWLHYFRDWLQGLQDAFDSDWETGRIMPNNY--KNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDK---ADYMPE------TRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRVICNNYT-SLGLSSYPNGYPFLFWEQYISLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1091
BLAST of patched-like protein vs. UniProt/SwissProt
Match: sp|O35595|PTC2_MOUSE (Protein patched homolog 2 OS=Mus musculus OX=10090 GN=Ptch2 PE=2 SV=2) HSP 1 Score: 210.69 bits (535), Expect = 7.681e-54 Identity = 241/1029 (23.42%), Postives = 429/1029 (41.69%), Query Frame = 1
Query: 367 FETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTH----NXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCP----NR-LKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLL----LQST----------SHVLETMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYD--CVRKDSNLLKSKIIFSTEFTTAPD---TFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRC----C--WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHV---ALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYT--NNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
ETD+ LW+ SR+ E + G E+ +L + H N L L L Y + S+ + C + +P + + + +E L PC I++PL+CFWEG+KL S Y R I W + + Q+ ++ F EL +A + ++ +PCLD D CP NR +Q P+ ++ GC + + + +G R LQ LL LQST H + +++ W E + V+ W ++ Q E++P NA SQ+I + F++ +L+ L ++ T + G ++ML + + + +S + + L+ A+ SGLGL A +G TFNA TTQV+PF+ +G+G++++ +L ++K P + + L T + ++ ++ ++P+P +R F +Q ++ ++P +L LD RR R+D+LCC +P S + +P++ V L + + T + T +P H LSP S+P S + S + L + + C C W + F +++ + V+L ++ + LY A + GL + PR + E ++ + F +VT+ F+Y ++Q L LHQ +L V + + WL + WL+ IQ+ FD+D + I + RN S++G L L++Q G E +++ +L+T +LV + G + FY+ L VW S + YP + D + + L + + PL+F + G Q+ DFV+ + + T + P G+ F EQYL LR ++ IL + F++ L + + L L+L+ + M I L+A V+ + S G+G F++ + + ++
Sbjct: 78 IETDLEQLWVEVGSRVSQELHYTKEKLGE--EAAYTSQMLIQTAHQEGGNVLTPEALDLHLQAALTASKVQVSLYGK-SWDLNKICYKSGVP---LIENGMIERMIEKLFPCVILTPLDCFWEGAKL------QGGSAYLPGRP-DIQWTNLD-PQQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLDPDDPHCPPSAPNRHSRQAPNVAQELSGGCHGFSHKFMHWQEELLLGGTARDLQGQLLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASMVLQAWQRRFVQLA---------QEALP-ANA---SQQI-----HAFSSTTLDDILRAFSEVST---TRVVGGYLLMLAYACVTMLRWDCAQSQGAVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDIFLLAHAFTK----APPDTPLPERMGECLRSTGTSVALTSVNNMVAFFMAALVPIPALRAFSLQAAIVVGCNFAAVMLVFPAILSLDLRRRHRQRLDVLCCF---SSPC-SAQVIQMLPQELGDRAVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHL--------LSPASDPLGSELYSPGGSTRDLLSQEEGTGPQAACRPLLCAHWTLAHFARYQFAPLLLQTRAKALVLLFFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRSWLQGIQAAFDQDWASGRITCHSY--RNGSEDGALAYKLLIQTGNAQEPLDFSQLTTRKLVDKEGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTG----------ENLRIPAAQPLEFAQFPFLLHGL--QKTADFVEAIEGARAACTEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLSPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASIGIGVEFTVHVALGFL 1041
BLAST of patched-like protein vs. UniProt/SwissProt
Match: sp|Q9Y6C5|PTC2_HUMAN (Protein patched homolog 2 OS=Homo sapiens OX=9606 GN=PTCH2 PE=1 SV=2) HSP 1 Score: 198.364 bits (503), Expect = 6.132e-50 Identity = 248/1086 (22.84%), Postives = 451/1086 (41.53%), Query Frame = 1
Query: 217 SSLKCKTNIKIWLKLKYFCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGS---IETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCP-----NRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYD--CVRKDSNLLKSKIIFSTEFTTAPD---TFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRC----C--WKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHV---ALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNF--TPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITS--RYTNNLSLPTIPIGNIFTLSEQYLKLRYQ-LVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
SLK ++ + + F ++ H K+L +G+ G LG + ET++ LW+ SR+ E + G + S I+T Q N L L L Y + S+ + C + +P + + + +E L PC I++PL+CFWEG+KL S Y R I W + + ++ ++ F EL +A + ++ +PCL D CP + +Q P+ ++ GC + + + +G +D +G LQ+ LL S + E + +++ W E + V+ W ++ Q E++P NA SQ+I S + + A + G ++ML + + + +S + + L+ A+ SGLGL A +G TFNA TTQV+PF+ +G+G+++V +L +++ + P+ + + +C ++++ S + L A ++P+P +R F +Q ++ ++P +L LD RR R+D+LCC + S + +P++ V L + + T + T +P H + P S+P S F S + L + ++ C C W + F +++ + V+++ ++ + LY A + GL + PR + E ++ + F +VT+ F+Y ++Q L LHQ +L V + + WL + WL+ IQ+ FD+D + I + RN S++G L L++Q G E +++ +L+T +LV R G + FY+ L VW S + YP + D + T R P+ PL+F + +G Q+ DFV+ + + + P G+ F EQYL LR L+ V I+L V +LL +N + A ++ +L ++ M I L+A V+ + S G+G F++ + + ++
Sbjct: 28 GSLKAPLWLRAYFQGLLFSLGCGIQRHCGKVLFLGLLAFGALALGLRMAIIETNLEQLWVEVGSRVSQELHYTKEKLGEEAAYTSQMLIQTARQ-EGENILTPEALGLHLQAALTASKVQVSLYGK-SWDLNKICYKSGVP---LIENGMIERMIEKLFPCVILTPLDCFWEGAKL------QGGSAYLPGRP-DIQWTNLD-PEQLLEELGPFASLEGFRELLDKAQVGQAYVGRPCLHPDDLHCPPSAPNHHSRQAPNVAHELSGGCHGFSHKFMHWQEELLLGGMARDPQGELLRAEALQSTFLLMSPRQLYEHFRGDYQTHDIGWSEEQASTVLQAWQRRFVQLA---------QEALP-ENA---SQQIHAFSSTTLDDILHAFSEVS--------AARVVGGYLLMLAYACVTMLRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIGVDDVFLLAHAFTEALPGT--------PLQERMGECLQRTGTSVVLTSINNMAAFLMA-ALVPIPALRAFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCCF----SSPCSAQVIQILPQELGDGTVPVGIAHLTATVQAFTHCEASSQHVVTILPPQAHL--------VPPPSDPLGSELFSPGGSTRDLLGQEEETRQKAACKSLPCARWNLAHFARYQFAPLLLQSHAKAIVLVLFGALLGLSLYGATLVQDGLALTDVVPRGTKEHAFLSAQLRYFSLYEVALVTQGGFDYAHSQRALFDLHQRFSSLKAVLPPPATQAPRTWLHYYRNWLQGIQAAFDQDWASGRITRHSY--RNGSEDGALAYKLLIQTGDAQEPLDFSQLTTRKLVDREGLIPPELFYMGLTVWVSSDPLGLAASQANFYPPPPEWLHDKYDTTGENLRIPPA------------QPLEFAQFPFLLRGL--QKTADFVEAIEGARAACAEAGQAGVHAYPSGSPFLFWEQYLGLRRCFLLAVCILLVCTFLVCALLLLNPWTAGLIVLVLAMMTVEL-FGIMGFLGIKLSAIPVVILVASVGIGVEFTVHVALGFL 1041
BLAST of patched-like protein vs. TrEMBL
Match: D2ILS0 (Patched-like protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 2375.51 bits (6155), Expect = 0.000e+0 Identity = 1317/1327 (99.25%), Postives = 1320/1327 (99.47%), Query Frame = 1
Query: 190 MVNMYIKGHSSLKCKTNIKIWLKLKYFCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLLLQSTSHVLETMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLVRNGKVDERKFYLFLNVWRSMSVEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSDHKTRSPFVRNSDSYRCKSRPSHKSSTKSFRSQVSRNGSKFDLTNDNSAHGKLXXXXXXXXXXXXXXXXXDCCDNDHINNXXXXXXXXXXXXXXXXXXXXXXENDSRFVRQNVESSLIIHYSIDGQGKSPKKDANFPPELAVKTSFKYRQPTGQDQQDGH 4170
MVNMYIKGHSSLKCKTNIKIWLKLKYFCYQKFVRYHHWKILLIGIGFLGLC LGFKSV+FETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNNLLSTEFLLEHLQLLQNVVNVTLQYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGI+SGFISKPCLDVTDASCPNRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLLLQSTSHVLETMKINNLEWPESK+QDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTNNSLNSALNQANKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTSTSLLIAAILSGLGLMAAIGFTFN LTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSKTFLHIIVLVPVQITVILVTLLIIVMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLVRNGKVDERKFYLFLNVWRSMSVEYETQPCLLYPKIEPFTVDNF PSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFLASILATLLLSSSILSPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTE PSSTEAQPDMEL VSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSDHKTRSPFVRNSDSYRCKSRPSHKSSTKSFRSQVSRNGSKFDLTNDNSAHGKLSIIPEESSSVQSSLKSKDC DNDHINNSSSSSDSSSSSSSSSSDSSQSQENDSRFVRQNVESSLIIHYSIDGQGKSPKKDANFPPELAVKTSFKYRQPTGQDQQDGH
Sbjct: 1 MVNMYIKGHSSLKCKTNIKIWLKLKYFCYQKFVRYHHWKILLIGIGFLGLCLLGFKSVQFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNNLLSTEFLLEHLQLLQNVVNVTLQYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIRSGFISKPCLDVTDASCPNRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLLLQSTSHVLETMKINNLEWPESKIQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTNNSLNSALNQANKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTSTSLLIAAILSGLGLMAAIGFTFNTLTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSKTFLHIIVLVPVQITVILVTLLIIVMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLVRNGKVDERKFYLFLNVWRSMSVEYETQPCLLYPKIEPFTVDNFIPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFLASILATLLLSSSILSPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTE--PSSTEAQPDMELGVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSDHKTRSPFVRNSDSYRCKSRPSHKSSTKSFRSQVSRNGSKFDLTNDNSAHGKLSIIPEESSSVQSSLKSKDCRDNDHINNSSSSSDSSSSSSSSSSDSSQSQENDSRFVRQNVESSLIIHYSIDGQGKSPKKDANFPPELAVKTSFKYRQPTGQDQQDGH 1325
BLAST of patched-like protein vs. TrEMBL
Match: D0VYP1 (Patched OS=Dugesia japonica OX=6161 GN=Djptc PE=2 SV=1) HSP 1 Score: 1650.18 bits (4272), Expect = 0.000e+0 Identity = 923/1327 (69.56%), Postives = 1123/1327 (84.63%), Query Frame = 1
Query: 190 MVNMYIKGHSSLKCKTNIKIWLKLKYFCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLLLQSTSHVLETMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYS---AVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLVRNGKVDERKFYLFLNVWRSMSVEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSDHKTRSPFVRN-SDSYRCKSRPSHKSSTKSFRSQVSRNGSKFDLTNDNSAHGKLXXXXXXXXXXXXXXXXXDCCDNDHINNXXXXXXXXXXXXXXXXXXXXXXENDSRFVRQNVESSLIIHYSIDGQGKSPKKDANFPPELAVKTSFKYRQPTGQDQ 4158
MV+MYIKGH+SLKCKTN K W KLKYF YQ+FV+YHHWKILL+GIGFLGLC LG+KS++F+ D+MNLWIYNSSRLHNETSFI + I+SGS+ETILQVS+ NNLLSTE+LLEHLQL+Q+++ +T+QYD R+FTFSDFCQRVQLPK+H LHD+S+RVSVEN+MPC+IISPLNCFWEGSKLLD+ +K K SNYDE +SIKIDWK FNISQEFFYSF++ S+Y FF ELF+EAGIKSGF+SKPC+DVTD SCPNR + YESI+ +GC+QIGE+MDKYSKS+FIGK+NRGLQT LLLQS+SHVLETMKINNL+WPESK+ VM +WL KL+QTVI++NS+RP L SIPYRN KFQSQR+RKSSFYVFTNN+LN+AL+ A+ DETLL KYL S G+VMLF+VL+F+SS+NLVRSHCWLA+TST LL+ AI+SGLGLMAA+GFTF A+TTQVVPF++VG+GL+EVIILTKKYS ID R K N+P+PVAQTLYDCATILMVSFS+KL+VL A +IP+PLMR+FCIQ++FI LQTGVN FLYPCLL+LD RR+SNRID+LCCLLKRQ+ ++ ES S PRQYD VRK+++ S+I+FSTEFTT+P+T IPNNVHQYCEINP+D RSEPSTS+SF + SVD+N E K ++N +H+CCWKF YRLSKTFLHII+LVPVQITVIL+T+++IVMGLYSA+NIDCGL+ +SIF RDSNE++Y+++ETE FR QNFEI+TKE +Y + Q+ +LQLH EI+ L V LLENGKFWLSSFI WL++IQ+DFD D+KNK IL+NGTW +NASKNGLL MTL+VQDGESINY KL+TSRL+++ KVDE KFYL LNVWRS+SV++++QPCLL+P+I PF++D+F P++Y KEPSVIRMSGLNLF+N+PL+FV+CKYF KG++ QEEL+FVKT+RSITSR+TNN S+PTIPIGNIF+ SEQYLKLRYQL+IVSIILA+GMFVISLLAINHFL S+LATLLLSSS+LSPMLFMN YQ+PLNATSGVMALWSGGLGFRFSLFLIVS+VEQ+++P +T P + V S + E V ++ G + + VNKQK I++ERAFN+V C KAVFSTFLGMAFI+MTDI FLW NFM++P VGL+HSLLNYYYLAPIFCFYLIPK+ K+R+ F + SYRCKS+ ++ S+K +RS SR+ SKFD ND+ HGKLSIIPEESSS+ SS+KS + +N HIN SSS S + N + F++QN+ESSL+I YS+DGQGKS KK+ +F PELAVKTSFKYRQP GQD
Sbjct: 1 MVSMYIKGHNSLKCKTNFKNWFKLKYFRYQEFVKYHHWKILLVGIGFLGLCLLGYKSMKFDKDIMNLWIYNSSRLHNETSFIPTTT-ENIDSGSVETILQVSSDNNLLSTEYLLEHLQLMQSIIKLTIQYDGRAFTFSDFCQRVQLPKMHDLHDKSIRVSVENIMPCKIISPLNCFWEGSKLLDYDTKMKISNYDEQKSIKIDWKFFNISQEFFYSFQDRSDYKFFIELFQEAGIKSGFVSKPCIDVTDGSCPNRHNSQSDYESIIKQGCSQIGENMDKYSKSLFIGKNNRGLQTLLLLQSSSHVLETMKINNLDWPESKISHVMKMWLNKLRQTVINYNSNRPLLGSIPYRNNKFQSQRLRKSSFYVFTNNALNAALSHASNDETLLVKYLISSGLVMLFIVLLFMSSENLVRSHCWLAITSTLLLVIAIISGLGLMAAVGFTFTAITTQVVPFLVVGIGLDEVIILTKKYSNTIDSFRLKKNYPNPVAQTLYDCATILMVSFSVKLLVLCATAIIPIPLMRSFCIQVIFITALQTGVNVFLYPCLLYLDFARRQSNRIDILCCLLKRQSSHEDLESQSESQTTPRQYDFVRKETDFSNSRIVFSTEFTTSPNTLIPNNVHQYCEINPID-KQRSEPSTSKSFHRSHSVDSNNEMKLMRNPKHQCCWKFRYRLSKTFLHIIMLVPVQITVILITIMVIVMGLYSAINIDCGLILDSIFSRDSNEYNYVRFETETFRLQNFEIITKELDYIHQQESVLQLHHEINELAQVELLENGKFWLSSFIFWLKKIQNDFDNDIKNKRILSNGTWMKNASKNGLLAMTLLVQDGESINYGKLTTSRLIKDEKVDENKFYLLLNVWRSVSVDFDSQPCLLFPQIAPFSIDSFLPNEYPKEPSVIRMSGLNLFTNNPLKFVSCKYFLKGRTPQEELEFVKTIRSITSRFTNNQSVPTIPIGNIFSFSEQYLKLRYQLLIVSIILAVGMFVISLLAINHFLPSVLATLLLSSSLLSPMLFMNFYQLPLNATSGVMALWSGGLGFRFSLFLIVSFVEQSDIP--ATGKTPSISEIVQSQSSTN---SSSEDVIRNRTGWMAHMK-CVNKQKQIQIERAFNEVQCDKAVFSTFLGMAFILMTDIGFLWHNFMMLPLVGLIHSLLNYYYLAPIFCFYLIPKTPQKSRNYFDKKPKSSYRCKSQNANIYSSKPYRSHSSRDISKFDENNDSFTHGKLSIIPEESSSILSSVKSTNSHEN-HIN------------DSSSDSSQSQENNTTHFMKQNIESSLVIQYSVDGQGKS-KKETSFSPELAVKTSFKYRQPMGQDH 1305
BLAST of patched-like protein vs. TrEMBL
Match: A0A0U2W010 (Patched1 (Fragment) OS=Novocrania anomala OX=317945 GN=ptc1 PE=2 SV=1) HSP 1 Score: 267.7 bits (683), Expect = 2.919e-69 Identity = 271/1089 (24.89%), Postives = 481/1089 (44.17%), Query Frame = 1
Query: 247 IWLK--LKYFCYQK--FVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKL-HYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLK-----QKPSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLE----TMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVML-FVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQT-------PNDSTESYSAVP--RQYDCVRKDSNL-LKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKR-----------------HR--CCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGE---SINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMSVEYETQPCLLYPKIEPFTVDNFT--PSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEEL-DFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSI-ILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+WL+ L+ + Y F++ H K+L +G+ L LC +G K+ ET+V LW+ RL E ++ G S S I T +++L + LL HLQ + +T+ D ++ F D C P DR L +N++PC II+PL+CFWEG+KLL + + S I W + N + + + EL AGI S + KPCLD TD CP Q P + + GC + + + +G K+ G LQ+ + L + E T K+N+++W + K + ++ W +K Q V Q+ ++ + S S ++ K L + G V+ML + + + N V S + + L+ + +GLG+ + G FNA TTQ++PF+ +GLG++++ +L +++N + + I + + L ++++ + +IP+P +R F +Q ++ ++P ++ +D RRE R+D+ CC + P S S P R+ SN+ L I ++ + H + P P S+ S L++ +L P +++ HR C W + + ++ V++ V+++ ++ +G++ + GL I PR++NEF ++ +++ F F N IVTK+ +Y N Q +L Q H+E + + E+G +FWL F WL +Q FDRD I + TW NA+ G+L L++Q G+ ++ ++ST RL+ NG ++ + FY +L W S L Y E NF P+K+ + + + L + + PL +V ++ + E + + ++ +RSI YT +PT P G FT EQYL LR+ L++ I +L + VI+++ +N + A ++ +L + + FM + I L+A V+ + S G+G F++ + V ++
Sbjct: 62 LWLRWHLQKYLYGLGCFIQRHCGKVLFVGLLMLSLCCIGLKTATIETNVEKLWVEEGGRLEQELTYTKDQLGEGSGSTSQIIIQTPKTGSSILRKDSLLTHLQAVLAATQITVVMDDITWKFKDICYMATFPSFDEAFIDRIL----DNIVPCVIITPLDCFWEGAKLLGPENPITVPGF----STAIKWTNLN-PLLLVDTLDKFFPMDGIRELLDRAGITSAYQEKPCLDPTDPECPATAPNKHSLQDPDIGASLTNGCTGFATKYMHWEEDLIVGGVRKNKTGHIVRAEALQSVVQLVGEKELYEYYQDTYKVNSIDWTQDKAKSILETWQRKFTQEV----------------------QKAVNATQDDLSAFSTTSLIDILQKFSQLSIARVALGYVLMLVYACISLLRWSNAVESQSGVGIAGVLLVALTVAAGLGMCSVFGIKFNASTTQILPFLALGLGVDDMFLLAHTFAENAN--KPDIFYMEQTGECLKRTGVAVLLTSVSNVCAFLMAAIIPIPALRAFSLQAATLVAFNLASILLVFPAIVSIDLYRREERRVDVFCCFTGSSSDRVIELNPGAKERSRSPPPSYREPSPPPTYSNVSLHQTIAHASN----------DGQHAVTVLGP----PESDSPVSGDASLSAVTATSLPPSVATSRQCLTGEEGLTCRERCAQTHRECCSWSLTWFAKTHYGPLLEKSSVKVFVVVLFGTLLGVGIWGITEVKDGLDLTDIVPRETNEFEFLDAQSKYFGFYNMYIVTKDLDYPNQQQLLYQYHREFKQVSKIIKKEDGSLPEFWLELFRQWLSDLQVAFDRDFSKGCITED-TWYANATAEGILGYKLLIQTGDVDSPLDKAQVSTMRLIDSNGNINPKAFYNYLTAWTS-------NDALAYGASEA----NFKPLPNKWYHDAA---DNELMIPKSQPLAYVQMSFYLNNLAQTENITETIRQIRSICDSYTEK-GIPTYPSGIPFTFWEQYLHLRFYLMLALICVLGVTFLVITIMLMNPWAAIVVEAVLAMTVVEL-FGFMGIVGIKLSAVPAVILIVSVGIGVEFTVHVCVGFL 1086
BLAST of patched-like protein vs. TrEMBL
Match: C3YM07 (Patched protein-like protein (Fragment) OS=Branchiostoma floridae OX=7739 GN=PTCH1 PE=4 SV=1) HSP 1 Score: 258.84 bits (660), Expect = 1.108e-66 Identity = 268/1094 (24.50%), Postives = 486/1094 (44.42%), Query Frame = 1
Query: 268 FCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETIL-------QVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFN---ISQEFFYSFKETSNY---NFFYELFKEAGIKSGFISKPCLDVTDASCPNRL-----KQKPSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLE----TMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCA--TILMVSFSIKLIVLSAL--TMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSK-----------------IIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSK----TFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTK-EFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGES---INYKKLSTSRLV-RNGKVDERKFYLFLNVW-RSMSVEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
F K ++ H K+L +G+ + L + K + ET+ LW+ RL E + G ++ + I V THN L + +Q + + D C LP L + +++E L PC II+PL+CFWEGSKLL NY S + W + N + +E S ++Y + F +LF +AGI +G+ KPCL+ D CP K+ P + S + GCA ++ + + +G K+ G LQT ++L + + E K++++ W SK +V+ W +K + V +NS L Q++ S + + + + + +G +ML + + + VRS + + L+ ++ + LG IG +FNA TTQV+PFV +GLG++++ ++ +S C + + QT +C T + V+ + I++S ++P+P +RN+ IQ ++ ++P ++ D RR + R+D+ CCL ++ TP + T+S + P R +N+ ++ T+ T P +IP+NV + P+ + PST+ S + V + E + ++ CC K ++ LS T+ + PV+I V++ L++V G+Y ++ GL + P+ S E +++ +++ F F N IVT+ +++Y N Q L LH++ ++ + L G ++WLS F WL +Q+ FD D + I N W NA+ G++ L+VQ G++ IN +L ++RL+ NG ++ + FY++L W + Y + P+ E + VD P L + + P+ + ++ G + + E + +K VR + +PT P+G FT EQY+ LRY L++ + +FV+ + + + +++ +L+ + M L I L+A V+ + S G+G F++ + +YV
Sbjct: 29 FNTGKIIQLHCGKVLFVGVLVMVLLAVFLKDAKIETETEKLWVQVGGRLEEELRYTKESLGEEMGTDYQVIITTAKNEGDNVLTHNALNQHLQSVLAAADVQVELFGV------DWNMKDVCYVTSLPVLEGV----FAMTIEKLYPCVIITPLDCFWEGSKLLGPDRPVIIPNY----SSNVRWTNLNPLGMLEELNKSSDIMASYFPLDTFQDLFDKAGITTGYQEKPCLNPEDPECPETAPNKYTKEVPDFNSELTGGCAGFATKYMQWPEELIVGGLKKNQSGQITSAEALQTAIVLSQPNALYEYYKDDYKVHDIHWSPSKAGEVLEEWQRKFTEAV--YNSANDSL-----------GQQVHAFSSAALNDLLQDFSQTNYIR--------VAAGYCLMLVYACVTMLRRSAVRSQGGVGLAGVILVSMSVAAALGFCTLIGLSFNASTTQVLPFVALGLGVDDMFLVAHTFS-----CTTSSPNVAYLDQT-GECLRRTGVSVTLTSLSIIVSCFMGAIVPIPALRNYSIQSAVVVFFNYLSVILIFPAIISWDLERRRNKRLDIFCCLNSSSSNRVIRVREATPEEDTDSVRSEPLPRHSQRHQTNVTVQSTVETVTSLDNEGRTVTVVVPPTQTVTRP--WIPSNV-----VTPIG----TPPSTAESSSTRNLVSPDFETEGTESSNVLCCAKKNWTLSSFARNTYGPFLARFPVKIAVLVAFALLLVGGIYGTTTVEDGLDTTDVVPKGSREHDFLRLQSKYFSFYNMYIVTQSDYDYPNGQAGLDSLHEDFMRVNKIVLTPEGNLPEYWLSYFRQWLFDVQAHFDEDWQLGRIQRN-KWFYNATNEGVMGYKLLVQTGDNDNPINKDQLYSNRLIDSNGVINSKAFYIYLTAWVNDDTFAYTASQAAIRPEPEQWGVDRNDHDNLDTIPEY----ELRIPKSQPINYSQFSFYVSGLKGTSEYIQLIKEVREVCEES----EVPTYPLGVPFTYWEQYIFLRYYLMVALAAVLAAIFVVVAIVMVNPWLALIVVSVLAMMAVELFGVMGLLGIKLSAIPAVIIIASVGIGVEFTVHICFAYV 1061
BLAST of patched-like protein vs. TrEMBL
Match: A0A1S3IK03 (protein patched homolog 1 isoform X1 OS=Lingula unguis OX=7574 GN=LOC106165040 PE=4 SV=1) HSP 1 Score: 257.684 bits (657), Expect = 6.603e-66 Identity = 297/1224 (24.26%), Postives = 526/1224 (42.97%), Query Frame = 1
Query: 208 KGHSSLK-CKTNIKIWLKLKYFCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISR--VSGSKIESGSIETILQV--STHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLL--DHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSN---YNFFYELFKEAGIKSGFISKPCLDVTDASCP----NRL-KQKPSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLE----TMKINNLEWPESKVQDVMNLWLQKLQQTVIHF-------NSHRPYLESIPYRNAKF-QSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSF-------PLNSSVDNNLEPKPLKNKRHRC------CWKFHY-RLSKT-FLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESIN-YKK--LSTSRLVRN-GKVDERKFYLFLNVWRSM-SVEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSI-ILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSD 3693
KG +S C ++ L+ + F F+ H K+L +G+ L LC +G K+ ET+V LW+ RL E ++ + GS I + E ++Q S N L LL +L YD ++ FSD C + P D + +E L PC IISPL+CFWEG+KLL DH + N S++ + W + N + + N + AGI +G++ K CLD TD CP N+L +Q+P S + GC + + + +G K+ G +Q+ + L + + E + K+ ++++ K + ++ W +K Q V N H S+ +F + +R + Y+F ++++ ++ + + V+S + + L+ ++ +GLG+ + +G FNA TTQ++PF+ +GLG++++ +L +++N ++I+ + L ++++ +IP+P +R F +Q +++ ++P ++ +D +R+E NR D+ CC T T+ PR+ + + + T T + H + P P+S+ SR P SS L P R C C F RL+K+ + ++ P +I V ++ + ++V G++ V + GL I PRD+NE+ ++ + + F F N IVTK+ Y N Q ++ LH+E ++ V E+G FWL F WL +Q FD+D + I +G W N+++ G L L++Q G+ + Y+K +TSRLV + G ++ + FY +L W + ++ Y+ + P+ + + D + R I + L+S P Y + +Q+ + ++ +R I YTNN L P G FT EQYL LR+ L++ I +L + VI+L+ +N + ++ +L + FM L I L+A V+ + S G+G F++ + V ++ IGS N++ I +E F P ST LG+A ++ ++ F+ R F + +V +LN L P+ PK +
Sbjct: 65 KGKASGNTCALWLRWHLQKQLFNLGCFIERHCGKVLFVGLLLLCLCCIGLKTATIETNVEKLWVEEGGRLDQEIAYTQKHLGEGSGITN---EIVIQTPKSGKNILSKDSLLLHLRTVLAATQITVDMYDI-TWRFSDLCNKPSFPSFE---DSLVDQMLEPLTPCVIISPLDCFWEGAKLLGPDH-AVNAGSSFQFG---GLKWTNLN-PEHLLSQLRSMGNIFPVQAIEDFLARAGITTGYVRKSCLDPTDPECPFTAPNKLSQQEPDIGSELTGGCDGFATKYMHWEEDLIVGGVHKNRSGHIVRAEAIQSIVQLMAEKQMFEYYEDSYKVTSIDFTREKARAILEAWQRKFTQVVQEMGNGTQEDNLHGFSSTSLLDMLKEFSEVSYVRVALGYIF----------------------------MLVYAIISLMRWTDFVQSQSGIGMAGVLLVALSVAAGLGICSVLGIRFNASTTQIIPFLALGLGVDDMFLLAHTFAENAK--NKEISSKEQTGECLKRTGVTVLLTSITNASAFFMAAIIPIPALRAFVLQAAILVIFNCASILLVFPAIVSVDLIRKEENRADVFCCFPGTST----TDVVELAPRERHTEHVAPPVYREPSP-PPSYQTITHTSAGGD-HAITVLGP----PQSDSPVSRQVSLSSVGPPSASSSRQCLTPDEGPTCREHCAQTQQECCHFSLTRLAKSKYGPMLETTPAKILVGVLFIALLVFGVWGIVKVKDGLDLTDIVPRDTNEWKFLDAQGKYFGFYNMYIVTKDSINYPNQQKMMFALHKEFLKINKVIKKEDGTLPDFWLELFRQWLLDLQLAFDQDWSSGCITTDG-WFANSTEEGRLGYLLLIQTGDVDDPYRKEQAATSRLVNDQGIINPQAFYNYLTAWVTNDALAYDASMAEIKPEPQHWVYDPSDQMELR-----IPKAQAILYSQMPF------YLNNMVDNQDVIATIEEIRKICDSYTNN-GLAVYPSGIPFTFWEQYLHLRFYLLLALICVLGVTFLVITLVLMNPWAGFMVVMVLAMIVVEL-FGFMGLIGIKLSAIPAVILIVSVGIGVEFTVHICVGFIT--------------------------------------AIGS-------RNRRMRIALEHMF--APVIHGAISTLLGVAMLVGSEFDFIVRYFFNVLTALVVLGVLNGLILLPVLLSIFGPKGE 1175
BLAST of patched-like protein vs. Ensembl Cavefish
Match: ptch2 (patched 2 [Source:NCBI gene;Acc:30181]) HSP 1 Score: 131.339 bits (329), Expect = 3.932e-30 Identity = 140/596 (23.49%), Postives = 264/596 (44.30%), Query Frame = 1
Query: 175 RKSYLMVNMYIKGHSSLKCKTNIKIWLKLKY----FCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGS---IETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNR-----LKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCC 1884
R + L +N + KG ++ + +W++ ++ F ++ H K+L IG+ G +G + ETD+ LW+ SR+ E + G + S I+T Q T N L LL L Y + S+ + C + +P + + + ++ L PC I++PL+CFWEGSKL S Y I W + + + + ++ F E+ +A + ++++PCLD D CP+ L+Q P + GC+ + + + + +G K+++G LQT LL S + E K I+++ W E K ++ W +K + V+H SIP ++ S+ Y F+ +LN + + + + G ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G++++ L S+ C ++ ++ + S + +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCC
Sbjct: 38 RHAALALNHFNKGKAAGQ---RAPVWIRARFQALLFTLGCHIQRHCGKVLFIGLLVFGALSVGLRVAAIETDIEQLWVEAGSRVSRELRYTKEKQGEETVFTSQMLIQTPKQEGT-NILTQEALLLHLEAALSASKVQVSLYGK-SWDLNKICFKSGVP---IIENVMIERMIDKLFPCMIVTPLDCFWEGSKL------QGGSAYLPGMP-DIQWMNLD-PLKLMEQLSQFTSLEGFREMLDKAQVGHAYMNRPCLDPNDPDCPHSAPNKDLRQSPEIAEELQGGCSGFSKKFMHWQEELILGERAKNSQGSLQSAEALQTMFLLMSPKQLYEHFKDDYEIHDINWNEDKATAILESWQRKFVE-VVH--------SSIPQNSS---------SNVYAFSTTTLNDIMKSFSDVSVI---RVAGGYLLMLAYACVTMLRWDCAKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDISNLLS--SERTGDCLRRTG------------TSVALTSIN-NMIAFFMAALVPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCC 581 HSP 2 Score: 86.2705 bits (212), Expect = 2.114e-16 Identity = 91/407 (22.36%), Postives = 168/407 (41.28%), Query Frame = 1
Query: 2509 KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSDHKTRS 3708
+ WL F WL +Q FD D ++ I + RN +++G L L++Q G E NY +L++ RLV +G + FY++L VW S + Y YP + D + + L + + PL+F ++ G + + + ++ +++VRS+ + + P G F EQY+ LR+ ++ +S++LA V ++L +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + + ++ G+ TR A +E F P STFLG+ + ++ F+ R F + + + +LN L P+ + P ++ S
Sbjct: 716 RMWLHYFQDWLRGLQVSFDADWESGRITPDSF--RNGTEDGALAYKLLIQTGSKKELFNYSQLTSRRLVDDDGMIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPHEWIHDKYDTTG----------ENLRIPAAEPLEFAQFPFYLNGLRQASDFIEAIESVRSVCEEFMRK-GIQNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAVLLLNPWTAGIIVFILAMMTVEL-FGIMGLIGIKLSAIPVVILIASVGIGVEFTVHVALGFLTA------------------------IGDRNTRSVAA---------------------LEHMF--APVMDGAISTFLGVLMLAGSEFDFIMRYFFAVLAILTLLGILNGLVLLPVLLSIMGPPAEGSNGS 1061
BLAST of patched-like protein vs. Ensembl Cavefish
Match: ptch1 (patched 1 [Source:NCBI gene;Acc:103030480]) HSP 1 Score: 123.635 bits (309), Expect = 8.400e-28 Identity = 107/436 (24.54%), Postives = 198/436 (45.41%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSN-YNFFYELFKEAGIKSGFISKPCLDVTDASC----PNRLKQKP-SYESIVNEGCAQIGEHMDKYSKSIFIGKDNR----------GLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTV---IHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLL 1890
+ENL PC II+PL+CFWEG+KL H S + W +F+ E K ++ + F E+ +A + G++ +PC++ D C PN+ +P ++ GC + + + + + +G N+ LQT L + + E +K ++++ W E K ++ W ++ + V + NS SQ++ FT +L L ++ + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S I ++AL IP+P +R F +Q +++ + ++P +L +D RRE R D+ CC +
Sbjct: 210 IENLHPCLIITPLDCFWEGAKL--HAGIAYLSG-----KPPLQWVNFD-PMELIAELKAVTHLVDSFEEMLVKAEVGHGYMDRPCINPADPDCPLSAPNKNSTRPLDIARVLTGGCYGVSKKYMHWQEELILGGTNKNESGRLLSAQALQTMFQLMTPKQMYEHLKGYEEVSHMNWNEDKAAAILEAWQRRYSEVVQQSVSINS----------------SQKV-----LTFTTTTLEDILKSF---SSVSGIRIASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVTLSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NRRIPFEDRTGECLKRTGASVALTSISNITAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFV 605 HSP 2 Score: 119.013 bits (297), Expect = 2.361e-26 Identity = 94/354 (26.55%), Postives = 177/354 (50.00%), Query Frame = 1
Query: 2287 LYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
LY + GL I PR++ E+ ++ + + F F N +VT++ Y Q +L ++HQ + +V +NG+ WL + WL+ +Q FD+D + I +N S +G+L L+VQ G + IN L+ RLV +G ++ FY++L W S V Y + P P + + T S I ++ L + + P+++ ++ G + + + ++ +++VRSI S Y+ +P+ P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 785 LYGTTCVRDGLELTDIVPRETAEYDFLGAQFQYFSFYNMYVVTQQANYAQAQPLLYEMHQRFGAVKYVLREDNGELPLMWLHYYRDWLQGLQEAFDKDWEVGRITQASY--KNGSDDGVLAYKLLVQTGRRDKPINLNLLTKHRLVDADGIINPNVFYIYLTAWVSNDPVAYAASQANIRPH-PPEWIHDRTDS--------IPINRLTIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRSICSNYSRQ-GMPSYPNGYPFLFWEQYVGLRHWLLLFISVVLASTFLVCAIFLLNPWTAGIIVLVLSLMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1125
BLAST of patched-like protein vs. Ensembl Cavefish
Match: ptch1 (patched 1 [Source:NCBI gene;Acc:103030480]) HSP 1 Score: 123.635 bits (309), Expect = 9.650e-28 Identity = 107/436 (24.54%), Postives = 198/436 (45.41%), Query Frame = 1
Query: 670 VENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSN-YNFFYELFKEAGIKSGFISKPCLDVTDASC----PNRLKQKP-SYESIVNEGCAQIGEHMDKYSKSIFIGKDNR----------GLQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTV---IHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLL 1890
+ENL PC II+PL+CFWEG+KL H S + W +F+ E K ++ + F E+ +A + G++ +PC++ D C PN+ +P ++ GC + + + + + +G N+ LQT L + + E +K ++++ W E K ++ W ++ + V + NS SQ++ FT +L L ++ + SG ++ML + + + +S + + L+ ++ +GLGL + IG +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S I ++AL IP+P +R F +Q +++ + ++P +L +D RRE R D+ CC +
Sbjct: 210 IENLHPCLIITPLDCFWEGAKL--HAGIAYLSG-----KPPLQWVNFD-PMELIAELKAVTHLVDSFEEMLVKAEVGHGYMDRPCINPADPDCPLSAPNKNSTRPLDIARVLTGGCYGVSKKYMHWQEELILGGTNKNESGRLLSAQALQTMFQLMTPKQMYEHLKGYEEVSHMNWNEDKAAAILEAWQRRYSEVVQQSVSINS----------------SQKV-----LTFTTTTLEDILKSF---SSVSGIRIASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVTLSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NRRIPFEDRTGECLKRTGASVALTSISNITAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFV 605 HSP 2 Score: 119.013 bits (297), Expect = 2.353e-26 Identity = 92/356 (25.84%), Postives = 174/356 (48.88%), Query Frame = 1
Query: 2281 MGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
+ LY + GL I PR++ E+ ++ + + F F N +VT++ Y Q +L ++HQ + +V +NG+ WL + WL+ +Q FD+D + I +N S +G+L L+VQ G + IN L+ RLV +G ++ FY++L W S V Y + P P I ++ L + + P+++ ++ G + + + ++ +++VRSI S Y+ +P+ P G F EQY+ LR+ L++ +S++LA V ++ +N + A I+ +L ++ M L I L+A V+ + S G+G F++ + ++++
Sbjct: 755 VSLYGTTCVRDGLELTDIVPRETAEYDFLGAQFQYFSFYNMYVVTQQANYAQAQPLLYEMHQRFGAVKYVLREDNGELPLMWLHYYRDWLQGLQEAFDKDWEVGRITQASY--KNGSDDGVLAYKLLVQTGRRDKPINLNLLTKHRLVDADGIINPNVFYIYLTAWVSNDPVAYAASQANIRPH---------PPEWIHDRTDSIPINRLTIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRSICSNYSRQ-GMPSYPNGYPFLFWEQYVGLRHWLLLFISVVLASTFLVCAIFLLNPWTAGIIVLVLSLMTVEL-FGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1097
BLAST of patched-like protein vs. Ensembl Nematostella
Match: EDO48180 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RK33]) HSP 1 Score: 248.054 bits (632), Expect = 3.578e-67 Identity = 263/1045 (25.17%), Postives = 471/1045 (45.07%), Query Frame = 1
Query: 361 VEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVST--HNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFN---------ISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPN-----RLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG--KDNR--------GLQTFLLLQSTSHVLETMKINN-LEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVM-LFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCA----TILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLK------RQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSKTFLHX----XXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVAL---LENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGE---SINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSM-SVEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKY--FHKGQSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPML----FMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQT 3327
++ ET+ LW+ RL E ++ G S E I+Q N+L+ LL HL+ ++ VT+ D + +T + C LP++ +++LR + L+PC IISPL+CFWEG+K+ H + S E + +K W + N I + F++ Y +FKEAGI SG+ KPCL+ D CP R K+ + + +GC K+ + + G K NR LQ+ +LL ++ + N+ + K ++ W ++ + + NA+ R S+ FT+ + N L +K T+ L G ++M L+ N V+SH L V L+ ++++G+GL + G FNA +TQV+PF+ +GLG++++ ++ Y+ DI HP Q Y ++L+ SF+ + L A +IP+P +R F IQ I++ ++P ++ +D R++ R DLLCC K TP+ ST++ ++ Q + S L + + T + + + + E+ P + P + LN+ +++ + K R W H L H + +I V+ + + G+Y + + GL + PR++ E ++ +++ F + VTKE++Y N Q ++ + H+ + ++ ++ FWL F WL+ +Q FD D + G W NAS G+L L+ Q G IN ++ + RLV +G + FY +L W ++ ++ Y I+P V+ + R++ S +RM + P+ F + FH +++++ + +K VR I + LP+ P G FT EQY+ LR Q ++V+II+ +G I+ + I FL S+ +++ +++ + FM L I L+A V + S G+G F++ + ++++ T
Sbjct: 60 IQMETNAEKLWVEAGGRLEEELAYTKGALGEGF-GASQELIIQTPNIEGTNILTPNALLLHLEAVRKATKVTVTIDNKKWTLKELCYAPNLPEIE---NKALRPIFDLLVPCAIISPLDCFWEGAKI--HGPEKNISFTPEKKLLK--WTTLNPIGLLDLLKIGLDIFHN----REYETIRTMFKEAGITSGYTEKPCLNPNDRECPRTAPNYRSKEALDIGASITDGCTGFAAKYMKWPEELIAGGVKKNRSGTIRSAGALQSIILLMGPQNMQRYYQDNDGQDLSTEKATQILEAWQRQFSKVM----------------NAESSRVRDEDSTVLAFTSTAFNDLLKDFSKSSTV---QLAIGYIIMVLYAGWSLKRWTNGVQSHGGLGVAGVILVTLSVVAGMGLCSFCGIAFNAASTQVLPFLALGLGVDDMFLIAHTYAAMSDI--------HPSDQVGYALGSAGVSVLLTSFNNMVAFLMA-AIIPIPALRAFSIQAAVIVVFNYLAVTIVFPAMIAIDVKRKQDQRYDLLCCFSKTVPQRISVTPDLSTDTGNSTAAQPPYIGA-SQLPSIGAVVTANGTISLPGAVTVHAAAFAELGPKTVYNTLLPLSVSE--LNNQTTQSMKSSRCERKHGRWHWLKHLSLEHFADHYYGPCLQKNSTKILVLFMFAAMFGAGVYGCMLVRDGLDLMDVVPRNTTEHKFVDAQSKYFSYYIMYAVTKEYDYPNGQKLMYKYHEAFSRVRNIIKSPDIKTQPFWLIYFRDWLKDMQQAFDSDWSTGCVTYEG-WRENASDYGILGYKLLSQTGNPDMPINRTQVRSIRLVDESGIIRPASFYNYLTAWMNVDTMGYTASQAF----IKPEAVNWYNLRDVREQHS-MRME-----AAKPITFAQLPFDLFHL-KTTEDIVQTIKEVRKICDEF-QAAGLPSYPSGIPFTFWEQYIMLR-QHLMVAIIIVLG---ITFIVIAGFLWSVWTAIIIDLTLVMITVQLFGFMGLAGIKLSAVPAVTLILSVGVGVEFTVHMCMAFLTST 1044
BLAST of patched-like protein vs. Ensembl Medaka
Match: ptch1 (patched 1 [Source:NCBI gene;Acc:101166055]) HSP 1 Score: 235.343 bits (599), Expect = 3.259e-62 Identity = 252/1048 (24.05%), Postives = 464/1048 (44.27%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVST-----HNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRV-QLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNY--NFFYELFKEAGIKSGFISKPCLDVTDASCP----NRLKQKP-SYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINP---VDLSPRSEPSTSRS------FPLNSSVDNNLEPKPLKNKRHRCCWKF---HYRLS----KTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
K+ ETDV LW+ R++ E ++ + G E L + T N L L ++ Y+R+ + C + +L + D+ +E L PC II+PL+CFWEG+KL F Y R + W +F+ Q F SN+ F + ++A I G++ +PCL+ D CP NR KP + ++ GC + + + + +G K+ G LQT L + + E + + ++ W E K ++ W R Y E++ A SQR+ FT +L L ++ + + SG ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R D+ CC YS P + + ++S + TE+ F Y P + + P + P T + P ++S +L + + CW+ + L+ K + ++ ++ VI++ L ++ + LY + GL I PR+++E+ +I + + F F N +VT+ +Y NQ +L QLHQ + +V +NG + WL F WL+ +Q FD+D + I + +N S +G+L L+VQ G + IN+ +L++ RLV +G ++ FY++L W S V Y + P P + + L++ + P+++ ++ G + + + ++ +++VR+I + Y+ LP+ P G F EQY+ LR+ L++ +S++LA V +L +N + A I+ +L ++ FM L I L+A V+ + S G+G F++ + ++++
Sbjct: 106 LKAANLETDVEKLWVEVGGRVNQELNYTRQKMG---EEAMFNPQLMIQTPREEGANVLTVEALLQHLESAMRASRVHVYLYNRQ-WNLEHLCYKSGELITEESMMDQM----IEKLHPCLIITPLDCFWEGAKL----QSGMF--YLPGRGY-LQWTNFDPKQ-----FLAESNFLVESFESMLEKADIGHGYMDRPCLNPADPDCPLTAPNRNSTKPFNVARALSGGCHGLSRKYMHWQEELIVGGTTKNGSGPLLSAQALQTMFQLMTPKQMFEHFRGYEEVAHINWNEEKAAAILEAW-------------QRRYSEAVLQSVAANSSQRVLS-----FTTTTLEDILKSFSEISVI---RVASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRCDIFCCF------------YSPPPSSHSFAHQTQITMQSTVQLRTEYDPRTQAF-------YTTAEPRSQISVQPMNPPPTRVNSDYLGHIPESNSSTRDLLSQTGEASFGLHCWESPCSRWTLASFAEKHYAPFLLQPTTKVVVIVLFLCLLGVSLYGTTQVRDGLELTDIVPRETSEYDFIGAQFKFFSFYNMYVVTQRADYAKNQQLLHQLHQRFHTIRYVLKEDNGQLPRMWLHFFRDWLQGLQEAFDKDWQAGRITHSSY--KNGSDDGILAYKLLVQTGRRDKPINFNQLTSQRLVDADGIINPGAFYIYLTAWVSNDPVAYAASQANIRPH---------PPEWLHDHTDSMPETRLSIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAICNNYSRQ-GLPSYPNGYPFLFWEQYVSLRHWLLLSISVVLACTFLVCALFLLNPWTAGIIVLVLSLMTVEL-FGFMGLMGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1072
BLAST of patched-like protein vs. Ensembl Medaka
Match: ptch2 (patched 2 [Source:NCBI gene;Acc:101159383]) HSP 1 Score: 216.083 bits (549), Expect = 3.366e-56 Identity = 273/1262 (21.63%), Postives = 536/1262 (42.47%), Query Frame = 1
Query: 166 PD--ERKSYLMVNMYIKGHSSLKC-KTNIKIWLKLKY----FCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYD--RRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCP-----NRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTE------SYSAVPRQY--------------------DCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRS----EPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKF---HYRLS----KTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSD 3693
PD R SY +K S K +W++ ++ F ++ H K+L IG+ G +G + + ET++ LW+ SR+ E + G + S + ++Q + + + +Q +S+ + C + +P + + + ++ L PC II+PL+CFWEG+KL S Y I W + + + + ++ F E+ +A + ++++PCL+ +D+ CP + P + GC + + + + +G K ++G LQT LL S + E K I+++ W E K ++ W +K + V H +SIP +++ S + F+ +LN + + + + G ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G++++ +L ++++ I L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCCL L Q +DS E + +A QY C +++ + + +++ +T+P + I Q I+P SP + +P S+ F SS +L + +K + C F H+ LS + + +++ + V++ L ++ + LY + GL I PRD+ E+ +I+ + + F F N +VT + F+Y +Q +L+QLH +++ +V + K WL F WL+ +Q+ FD D + I A+ RN +++G L L++Q G + NY +L++ +L+ G + FY++L VW S + Y YP + D + + L + + PL+F ++ G + + + ++ +++VR+I ++ + P G F EQY+ LR+ ++ +S++LA V ++L +N + A ++ +L ++ M L I L+A V+ + S G+G F++ + + ++ + GD NK+ + +E F P ST LG+ + ++ F+ R F + + V +LN L P+ + P ++
Sbjct: 29 PDLIRRPSYCHAAFALKQISKGKAVGQKAPLWIRARFQALLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVADIETNIEQLWVEAGSRVSTELRYTKEKQGEESVFTS-QMLIQTPKEEGSNILTQEALLVHMEAALSASKVQVSLFGKSWDLNKICYKSGVP---IIENVMIERMIDKLFPCMIITPLDCFWEGAKL------QGGSAYLPGMP-DIQWMNLD-PVKLMEELSQFTSLEGFKEMLDKAQVGHAYMNRPCLNPSDSDCPLSAPNKEQGESPDIAGGLQGGCHGFSQKFMHWQEELILGGQVKSSQGTLLSAEALQTMFLLMSPKQLYEHFKDDYEIHDINWNEEKATAILESWQRKFVEEV-----H----QSIPANSSQ---------SIHAFSTTTLNDIMKSFSDVSVI---RVAGGYLLMLAYACVTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSFTES----GTNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAIVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCCLYSPCSDRVIHLAPQELSDSGEQPYVATTGTAHAHQYTAGSTITTSTQITTTVQAFTQCDAAGQHIV-TILPPTSQISTSPTSIIVCPTSQAQAISP---SPSTTSVPDPYGSQLFTPTSSSTRDLLAQVEDSKSGKRCVPFPFLHWNLSSFAREKYAPLLLQPKSKAIVVVFFLGLLGLSLYGTTMVHDGLYLTDIVPRDTKEYDFIEAQFKYFSFYNMYLVTMDGFDYARSQRLLIQLHNAFNSVRNVVRDNDNKLPRMWLHYFQDWLKGLQAAFDADWQEGRITADSY--RNGTEDGALAYKLLIQTGSKKDPFNYSQLTSRQLLDAEGLIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTG----------ENLRIPAAEPLEFAQFPFYLNGLRQASDFVETIESVRAICDEFSRK-GVFNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWTAGLIVFILAMMTVEL-FGMMGLIGIKLSAIPVVILISSVGIGVEFTVHIALGFLT---------------------AIGDR------------------------NKRSAVALEHMF--APVVDGAISTLLGVLMLAGSEFDFIMRYFFAVLAILTVLGILNGLVLLPVLLSMMGPPAE 1188
BLAST of patched-like protein vs. Ensembl Medaka
Match: ptch2 (patched 2 [Source:NCBI gene;Acc:101159383]) HSP 1 Score: 210.305 bits (534), Expect = 2.103e-54 Identity = 267/1255 (21.27%), Postives = 519/1255 (41.35%), Query Frame = 1
Query: 166 PD--ERKSYLMVNMYIKGHSSLKC-KTNIKIWLKLKY----FCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYD--RRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCP-----NRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCL----------LKRQTPNDSTE------SYSAVPRQY--------------------DCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRS----EPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSD 3693
PD R SY +K S K +W++ ++ F ++ H K+L IG+ G +G + + ET++ LW+ SR+ E + G + S + ++Q + + + +Q +S+ + C + +P + + + ++ L PC II+PL+CFWEG+KL S Y I W + + + + ++ F E+ +A + ++++PCL+ +D+ CP + P + GC + + + + +G K ++G LQT LL S + E K I+++ W E K ++ W +K + V H +SIP +++ S + F+ +LN + + + + G ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G++++ +L ++++ I L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCCL L Q +DS E + +A QY C +++ + + +++ +T+P + I Q I+P SP + +P S+ F SS +L + +K + + T +H GLY I PRD+ E+ +I+ + + F F N +VT + F+Y +Q +L+QLH +++ +V + K WL F WL+ +Q+ FD D + I A+ RN +++G L L++Q G + NY +L++ +L+ G + FY++L VW S + Y YP + D + + L + + PL+F ++ G + + + ++ +++VR+I ++ + P G F EQY+ LR+ ++ +S++LA V ++L +N + A ++ +L ++ M L I L+A V+ + S G+G F++ + + ++ + GD NK+ + +E F P ST LG+ + ++ F+ R F + + V +LN L P+ + P ++
Sbjct: 29 PDLIRRPSYCHAAFALKQISKGKAVGQKAPLWIRARFQALLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVADIETNIEQLWVEAGSRVSTELRYTKEKQGEESVFTS-QMLIQTPKEEGSNILTQEALLVHMEAALSASKVQVSLFGKSWDLNKICYKSGVP---IIENVMIERMIDKLFPCMIITPLDCFWEGAKL------QGGSAYLPGMP-DIQWMNLD-PVKLMEELSQFTSLEGFKEMLDKAQVGHAYMNRPCLNPSDSDCPLSAPNKEQGESPDIAGGLQGGCHGFSQKFMHWQEELILGGQVKSSQGTLLSAEALQTMFLLMSPKQLYEHFKDDYEIHDINWNEEKATAILESWQRKFVEEV-----H----QSIPANSSQ---------SIHAFSTTTLNDIMKSFSDVSVI---RVAGGYLLMLAYACVTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVLPFLALGIGVDDMFLLAHSFTES----GTNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAIVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCCLYSPCSDRVIHLAPQELSDSGEQPYVATTGTAHAHQYTAGSTITTSTQITTTVQAFTQCDAAGQHIV-TILPPTSQISTSPTSIIVCPTSQAQAISP---SPSTTSVPDPYGSQLFTPTSSSTRDLLAQVEDSKSGKSLY------GTTMVHD--------------------GLY----------LTDIVPRDTKEYDFIEAQFKYFSFYNMYLVTMDGFDYARSQRLLIQLHNAFNSVRNVVRDNDNKLPRMWLHYFQDWLKGLQAAFDADWQEGRITADSY--RNGTEDGALAYKLLIQTGSKKDPFNYSQLTSRQLLDAEGLIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTG----------ENLRIPAAEPLEFAQFPFYLNGLRQASDFVETIESVRAICDEFSRK-GVFNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWTAGLIVFILAMMTVEL-FGMMGLIGIKLSAIPVVILISSVGIGVEFTVHIALGFLT---------------------AIGDR------------------------NKRSAVALEHMF--APVVDGAISTLLGVLMLAGSEFDFIMRYFFAVLAILTVLGILNGLVLLPVLLSMMGPPAE 1145
BLAST of patched-like protein vs. Ensembl Medaka
Match: ptch2 (patched 2 [Source:NCBI gene;Acc:101159383]) HSP 1 Score: 196.052 bits (497), Expect = 3.825e-50 Identity = 252/1200 (21.00%), Postives = 507/1200 (42.25%), Query Frame = 1
Query: 223 LKCKTNIKIWLKLKY----FCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYD--RRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCP-----NRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKF---HYRLS----KTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKE-FEYTNNQDILLQLHQEIDNLHHVALLENGKF---WLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSD 3693
L +W++ ++ F ++ H K+L IG+ G +G + + ET++ LW+ SR+ E + G + S + ++Q + + + +Q +S+ + C + +P + + + ++ L PC II+PL+CFWEG+KL S Y I W + + + + ++ F E+ +A + ++++PCL+ +D+ CP + P + GC + + + + +G K ++G LQT LL S + E K I+++ W E K ++ W +K + +H +SIP +++ S + F+ +LN + + + + G ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV + +G++++ +L ++++ I L T + ++ +I ++P+P +R F +Q +++ + ++P +L LD RRE R+D+LCCL +P S P++ + ++ + + T+ A + I P + P S+ F SS +L + +K + C F H+ LS + + +++ + V++ L ++ + LY + GL I PRD+ E+ +I+ + + F F N +VT + F+Y +Q +L+QLH +++ +V + K WL F WL+ +Q+ FD D + I A+ RN +++G L L++Q G + NY +L++ +L+ G + FY++L VW S + Y YP + D + + L + + PL+F ++ G + + + ++ +++VR+I ++ + P G F EQY+ LR+ ++ +S++LA V ++L +N + A ++ +L ++ M L I L+A V+ + S G+G F++ + + ++ + GD NK+ + +E F P ST LG+ + ++ F+ R F + + V +LN L P+ + P ++
Sbjct: 26 LAVGQKAPLWIRARFQALLFSLGCHIQRHCGKVLFIGLLVFGALSVGLRVADIETNIEQLWVEAGSRVSTELRYTKEKQGEESVFTS-QMLIQTPKEEGSNILTQEALLVHMEAALSASKVQVSLFGKSWDLNKICYKSGVP---IIENVMIERMIDKLFPCMIITPLDCFWEGAKL------QGGSAYLPGMP-DIQWMNLD-PVKLMEELSQFTSLEGFKEMLDKAQVGHAYMNRPCLNPSDSDCPLSAPNKEQGESPDIAGGLQGGCHGFSQKFMHWQEELILGGQVKSSQGTLLSAEALQTMFLLMSPKQLYEHFKDDYEIHDINWNEEKATAILESWQRKFVE--VH--------QSIPANSSQ---------SIHAFSTTTLNDIMKSFSDVSVI---RVAGGYLLMLAYACVTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLLGLSFNAATTQVQ--LRGRIGVDDMFLLAHSFTES----GTNIPFKERTGDCLRRTGTSVALTSINNMIAFFMAALVPIPALRAFSLQAAIVVVFNFAMVLLIFPAILSLDLHRREDKRLDILCCLY---SPC-SDRVIHLAPQELSDSGEQPYVITTTVQAFTQCDAAGQHIV--------TILPPTSQISTNPYGSQLFTPTSSSTRDLLAQVEDSKSGKRCVPFPFLHWNLSSFAREKYAPLLLQPKSKAIVVVFFLGLLGLSLYGTTMVHDGLYLTDIVPRDTKEYDFIEAQFKYFSFYNMYLVTMDGFDYARSQRLLIQLHNAFNSVRNVVRDNDNKLPRMWLHYFQDWLKGLQAAFDADWQEGRITADSY--RNGTEDGALAYKLLIQTGSKKDPFNYSQLTSRQLLDAEGLIPPEVFYIYLTVWVSNDPLGYAASQANFYPHPREWIHDKYDTTG----------ENLRIPAAEPLEFAQFPFYLNGLRQASDFVETIESVRAICDEFSRK-GVFNYPNGYPFLFWEQYIGLRHWFLLSISVVLACTFLVCAILLLNPWTAGLIVFILAMMTVEL-FGMMGLIGIKLSAIPVVILISSVGIGVEFTVHIALGFLT---------------------AIGDR------------------------NKRSAVALEHMF--APVVDGAISTLLGVLMLAGSEFDFIMRYFFAVLAILTVLGILNGLVLLPVLLSMMGPPAE 1112
BLAST of patched-like protein vs. Ensembl Medaka
Match: ptch1 (patched 1 [Source:NCBI gene;Acc:101166055]) HSP 1 Score: 134.035 bits (336), Expect = 6.086e-31 Identity = 97/354 (27.40%), Postives = 180/354 (50.85%), Query Frame = 1
Query: 2287 LYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENG---KFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDG---ESINYKKLSTSRLV-RNGKVDERKFYLFLNVWRSMS-VEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKG-QSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVI-VSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYV 3318
LY + GL I PR+++E+ +I + + F F N +VT+ +Y NQ +L QLHQ + +V +NG + WL F WL+ +Q FD+D + I + +N S +G+L L+VQ G + IN+ +L++ RLV +G ++ FY++L W S V Y + P P + + L++ + P+++ ++ G + + + ++ +++VR+I + Y+ LP+ P G F EQY+ LR+ L++ +S++LA V +L +N + A I+ +L ++ FM L I L+A V+ + S G+G F++ + ++++
Sbjct: 836 LYGTTQVRDGLELTDIVPRETSEYDFIGAQFKFFSFYNMYVVTQRADYAKNQQLLHQLHQRFHTIRYVLKEDNGQLPRMWLHFFRDWLQGLQEAFDKDWQAGRITHSSY--KNGSDDGILAYKLLVQTGRRDKPINFNQLTSQRLVDADGIINPGAFYIYLTAWVSNDPVAYAASQANIRPH---------PPEWLHDHTDSMPETRLSIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAICNNYSRQ-GLPSYPNGYPFLFWEQYVSLRHWLLLSISVVLACTFLVCALFLLNPWTAGIIVLVLSLMTVEL-FGFMGLMGIKLSAVPVVILIASVGIGVEFTVHVALAFL 1176 HSP 2 Score: 123.635 bits (309), Expect = 8.001e-28 Identity = 133/544 (24.45%), Postives = 237/544 (43.57%), Query Frame = 1
Query: 352 FKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVST-----HNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRV-QLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNY--NFFYELFKEAGIKSGFISKPCLDVTDASC----PNRLKQKP-SYESIVNEGCAQIGEHMDKYSKSIFIG---KDNRG-------LQTFLLLQSTSHVLETMK----INNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDC-----ATILMVSFS-IKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCC 1884
K+ ETDV LW+ R++ E ++ + G E L + T N L L ++ Y+R+ + C + +L + D+ +E L PC II+PL+CFWEG+KL F Y R + W +F+ Q F SN+ F + ++A I G++ +PCL+ D C PNR KP + ++ GC + + + + +G K+ G LQT L + + E + + ++ W E K ++ W ++ + V L+S+ A SQR+ FT +L L ++ + + SG ++ML + + + +S + + L+ ++ +GLGL + +G +FNA TTQV+PF+ +G+G+++V +L +S+ N P +C A++ + S S + ++AL IP+P +R F +Q +++ + ++P +L +D RRE R D+ CC
Sbjct: 106 LKAANLETDVEKLWVEVGGRVNQELNYTRQKMG---EEAMFNPQLMIQTPREEGANVLTVEALLQHLESAMRASRVHVYLYNRQ-WNLEHLCYKSGELITEESMMDQM----IEKLHPCLIITPLDCFWEGAKL----QSGMF--YLPGRGY-LQWTNFDPKQ-----FLAESNFLVESFESMLEKADIGHGYMDRPCLNPADPDCPLTAPNRNSTKPFNVARALSGGCHGLSRKYMHWQEELIVGGTTKNGSGPLLSAQALQTMFQLMTPKQMFEHFRGYEEVAHINWNEEKAAAILEAWQRRYSEAV---------LQSV----AANSSQRVLS-----FTTTTLEDILKSFSEISVI---RVASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQ------NKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAAL--IPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRCDIFCC 600
BLAST of patched-like protein vs. Planmine SMEST
Match: SMESG000003567.1 (SMESG000003567.1) HSP 1 Score: 2394 bits (6203), Expect = 0.000e+0 Identity = 1324/1324 (100.00%), Postives = 1324/1324 (100.00%), Query Frame = 1
Query: 199 MYIKGHSSLKCKTNIKIWLKLKYFCYQKFVRYHHWKXXXXXXXXXXXXXXXFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNXXXXXXXXXXXXXXXXXXXXXXXXYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLLLQSTSHVLETMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTXXXXXXXXXXXXKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTXXXXXXXXXXXXXXXXXXXXFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSKTFLHXXXXXXXXXXXXXXXXXXXXMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLVRNGKVDERKFYLFLNVWRSMSVEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFXXXXXXXXXXXXXXXXPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSDHKTRSPFVRNSDSYRCKSRPSHKSSTKSFRSQVSRNGSKFDLTNDNSAHGKLXXXXXXXXXXXXXXXXXDCCDNDHINNXXXXXXXXXXXXXXXXXXXXXXENDSRFVRQNVESSLIIHYSIDGQGKSPKKDANFPPELAVKTSFKYRQPTGQDQQDGH 4170
MYIKGHSSLKCKTNIKIWLKLKYFCYQKFVRYHHWKILLIGIGFLGLCWLGFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNNLLSTEFLLEHLQLLQNVVNVTLQYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLLLQSTSHVLETMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTNNSLNSALNQANKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTSTSLLIAAILSGLGLMAAIGFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSKTFLHIIVLVPVQITVILVTLLIIVMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLVRNGKVDERKFYLFLNVWRSMSVEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFLASILATLLLSSSILSPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSDHKTRSPFVRNSDSYRCKSRPSHKSSTKSFRSQVSRNGSKFDLTNDNSAHGKLSIIPEESSSVQSSLKSKDCCDNDHINNSSSSSDSSSSSSSSSSDSSQSQENDSRFVRQNVESSLIIHYSIDGQGKSPKKDANFPPELAVKTSFKYRQPTGQDQQDGH
Sbjct: 1 MYIKGHSSLKCKTNIKIWLKLKYFCYQKFVRYHHWKILLIGIGFLGLCWLGFKSVEFETDVMNLWIYNSSRLHNETSFISRVSGSKIESGSIETILQVSTHNNLLSTEFLLEHLQLLQNVVNVTLQYDRRSFTFSDFCQRVQLPKLHYLHDRSLRVSVENLMPCRIISPLNCFWEGSKLLDHYSKNKFSNYDESRSIKIDWKSFNISQEFFYSFKETSNYNFFYELFKEAGIKSGFISKPCLDVTDASCPNRLKQKPSYESIVNEGCAQIGEHMDKYSKSIFIGKDNRGLQTFLLLQSTSHVLETMKINNLEWPESKVQDVMNLWLQKLQQTVIHFNSHRPYLESIPYRNAKFQSQRIRKSSFYVFTNNSLNSALNQANKDETLLAKYLTSGGVVMLFVVLIFVSSDNLVRSHCWLAVTSTSLLIAAILSGLGLMAAIGFTFNALTTQVVPFVMVGLGLEEVIILTKKYSKNIDICRQKINHPHPVAQTLYDCATILMVSFSIKLIVLSALTMIPVPLMRNFCIQILFIMLLQTGVNAFLYPCLLHLDSVRRESNRIDLLCCLLKRQTPNDSTESYSAVPRQYDCVRKDSNLLKSKIIFSTEFTTAPDTFIPNNVHQYCEINPVDLSPRSEPSTSRSFPLNSSVDNNLEPKPLKNKRHRCCWKFHYRLSKTFLHIIVLVPVQITVILVTLLIIVMGLYSAVNIDCGLLFESIFPRDSNEFHYIKYETELFRFQNFEIVTKEFEYTNNQDILLQLHQEIDNLHHVALLENGKFWLSSFIGWLERIQSDFDRDVKNKLILANGTWSRNASKNGLLVMTLMVQDGESINYKKLSTSRLVRNGKVDERKFYLFLNVWRSMSVEYETQPCLLYPKIEPFTVDNFTPSKYRKEPSVIRMSGLNLFSNHPLQFVACKYFHKGQSSQEELDFVKTVRSITSRYTNNLSLPTIPIGNIFTLSEQYLKLRYQLVIVSIILAIGMFVISLLAINHFLASILATLLLSSSILSPMLFMNLYQIPLNATSGVMALWSGGLGFRFSLFLIVSYVEQTEMPPSSTEAQPDMELSVSPSSGDTGNERTREPVAKDCIGSIFSVTFMVNKQKLIRVERAFNDVPCGKAVFSTFLGMAFIIMTDISFLWRNFMLIPFVGLVHSLLNYYYLAPIFCFYLIPKSDHKTRSPFVRNSDSYRCKSRPSHKSSTKSFRSQVSRNGSKFDLTNDNSAHGKLSIIPEESSSVQSSLKSKDCCDNDHINNSSSSSDSSSSSSSSSSDSSQSQENDSRFVRQNVESSLIIHYSIDGQGKSPKKDANFPPELAVKTSFKYRQPTGQDQQDGH 1324 The following BLAST results are available for this feature:
BLAST of patched-like protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of patched-like protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of patched-like protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 1
BLAST of patched-like protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of patched-like protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of patched-like protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of patched-like protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of patched-like protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of patched-like protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of patched-like protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of patched-like protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of patched-like protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of patched-like protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of patched-like protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029695 ID=SMED30029695|Name=patched-like protein|organism=Schmidtea mediterranea sexual|type=transcript|length=4428bpback to top protein sequence of SMED30029695-orf-1 >SMED30029695-orf-1 ID=SMED30029695-orf-1|Name=SMED30029695-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1328bp MVNMYIKGHSSLKCKTNIKIWLKLKYFCYQKFVRYHHWKILLIGIGFLGLback to top Aliases
The feature 'patched-like protein' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
