Multidrug resistance protein 1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029674 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of Multidrug resistance protein 1 vs. Ensembl Human
Match: ABCB4 (ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45]) HSP 1 Score: 331.643 bits (849), Expect = 1.769e-122 Identity = 173/339 (51.03%), Postives = 224/339 (66.08%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G ++ + +Y+ Y F GA + G ++ VFS ALG A S A D KA+ +A +R ID++ +G+ P+ K GNI F + F YPTRANV VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP G VLLDG + K LN+ W+R Q+G+V QEP LF+ S+A+NI YG NS V + ++ AK ANIH FI +LP Y T VG +G LSGGQKQRI IARAL +P ILLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+ +NG V E GTH++L+ +G Y+ +
Sbjct: 938 GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA------GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1269 HSP 2 Score: 129.798 bits (325), Expect = 1.769e-122 Identity = 100/340 (29.41%), Postives = 179/340 (52.65%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLT---PTDAATR--RLSSTANEEEFKLEKPSKIQMIKD----------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLV--LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
VRNAD+I ++G I+EQG+H L+ +G+Y++++ Q + + ++ + K T P +R R S+ N + ++ + S + + D F++++++++ E Y + G + A G + P S+I++E+ +F D + + + + L+ L G I F + + KAGE LT RLR+ ++L+Q+M++FD+ +N G L+ RLA +A+ V+ A G +L++ + I NL + I F Y W+L+LL L +P IA++GI++ KL G + L AG + E + NIRTV SL+ + F Y + L
Sbjct: 594 VRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKS-LDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGP----GDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAG-----KIATEAIENIRTVVSLTQERKFESMYVEKL 923 HSP 3 Score: 300.056 bits (767), Expect = 1.728e-87 Identity = 157/338 (46.45%), Postives = 222/338 (65.68%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
G+A +Y Y + F+ G+ + + + + M VF + ++G+A AR AA ID ID+ +G P+ + GN+EF ++HF YP+RANV +L+GL+LK+ +GQTVALVG SGCGKST +QL++R YDP +G + +DG DI+ N++++R IG+V QEP LF+ ++A+NI YG +V + + K K AN ++FI+ LP+ ++T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VQ ALD+A+E T +VIAHRLST++NAD I E+GV+VE G+H EL+ G Y+ L N+Q
Sbjct: 302 GIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDS-IKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDP------DEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
BLAST of Multidrug resistance protein 1 vs. Ensembl Human
Match: ABCB4 (ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45]) HSP 1 Score: 331.643 bits (849), Expect = 1.769e-122 Identity = 173/339 (51.03%), Postives = 224/339 (66.08%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G ++ + +Y+ Y F GA + G ++ VFS ALG A S A D KA+ +A +R ID++ +G+ P+ K GNI F + F YPTRANV VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP G VLLDG + K LN+ W+R Q+G+V QEP LF+ S+A+NI YG NS V + ++ AK ANIH FI +LP Y T VG +G LSGGQKQRI IARAL +P ILLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+ +NG V E GTH++L+ +G Y+ +
Sbjct: 938 GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLA------GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1269 HSP 2 Score: 129.798 bits (325), Expect = 1.769e-122 Identity = 100/340 (29.41%), Postives = 179/340 (52.65%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLT---PTDAATR--RLSSTANEEEFKLEKPSKIQMIKD----------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLV--LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
VRNAD+I ++G I+EQG+H L+ +G+Y++++ Q + + ++ + K T P +R R S+ N + ++ + S + + D F++++++++ E Y + G + A G + P S+I++E+ +F D + + + + L+ L G I F + + KAGE LT RLR+ ++L+Q+M++FD+ +N G L+ RLA +A+ V+ A G +L++ + I NL + I F Y W+L+LL L +P IA++GI++ KL G + L AG + E + NIRTV SL+ + F Y + L
Sbjct: 594 VRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKS-LDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGP----GDDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAG-----KIATEAIENIRTVVSLTQERKFESMYVEKL 923 HSP 3 Score: 300.056 bits (767), Expect = 1.728e-87 Identity = 157/338 (46.45%), Postives = 222/338 (65.68%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
G+A +Y Y + F+ G+ + + + + M VF + ++G+A AR AA ID ID+ +G P+ + GN+EF ++HF YP+RANV +L+GL+LK+ +GQTVALVG SGCGKST +QL++R YDP +G + +DG DI+ N++++R IG+V QEP LF+ ++A+NI YG +V + + K K AN ++FI+ LP+ ++T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VQ ALD+A+E T +VIAHRLST++NAD I E+GV+VE G+H EL+ G Y+ L N+Q
Sbjct: 302 GIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDS-IKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDP------DEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
BLAST of Multidrug resistance protein 1 vs. Ensembl Human
Match: ABCB4 (ATP binding cassette subfamily B member 4 [Source:HGNC Symbol;Acc:HGNC:45]) HSP 1 Score: 327.791 bits (839), Expect = 1.989e-121 Identity = 172/340 (50.59%), Postives = 224/340 (65.88%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQ-GQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G ++ + +Y+ Y F GA + G ++ VFS ALG A S A D KA+ +A +R ID++ +G+ P+ K GNI F + F YPTRANV VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP + G LLDG + K LN+ W+R Q+G+V QEP LF+ S+A+NI YG NS V + ++ AK ANIH FI +LP Y T VG +G LSGGQKQRI IARAL +P ILLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+ +NG V E GTH++L+ +G Y+ +
Sbjct: 938 GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276 HSP 2 Score: 129.798 bits (325), Expect = 1.989e-121 Identity = 100/340 (29.41%), Postives = 179/340 (52.65%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLT---PTDAATR--RLSSTANEEEFKLEKPSKIQMIKD----------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLV--LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
VRNAD+I ++G I+EQG+H L+ +G+Y++++ Q + + ++ + K T P +R R S+ N + ++ + S + + D F++++++++ E Y + G + A G + P S+I++E+ +F D + + + + L+ L G I F + + KAGE LT RLR+ ++L+Q+M++FD+ +N G L+ RLA +A+ V+ A G +L++ + I NL + I F Y W+L+LL L +P IA++GI++ KL G + L AG + E + NIRTV SL+ + F Y + L
Sbjct: 594 VRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKS-LDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPG----DDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAG-----KIATEAIENIRTVVSLTQERKFESMYVEKL 923 HSP 3 Score: 299.671 bits (766), Expect = 2.046e-87 Identity = 157/338 (46.45%), Postives = 222/338 (65.68%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
G+A +Y Y + F+ G+ + + + + M VF + ++G+A AR AA ID ID+ +G P+ + GN+EF ++HF YP+RANV +L+GL+LK+ +GQTVALVG SGCGKST +QL++R YDP +G + +DG DI+ N++++R IG+V QEP LF+ ++A+NI YG +V + + K K AN ++FI+ LP+ ++T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VQ ALD+A+E T +VIAHRLST++NAD I E+GV+VE G+H EL+ G Y+ L N+Q
Sbjct: 302 GIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDS-IKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDP------DEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
BLAST of Multidrug resistance protein 1 vs. Ensembl Human
Match: ABCB5 (ATP binding cassette subfamily B member 5 [Source:HGNC Symbol;Acc:HGNC:46]) HSP 1 Score: 313.153 bits (801), Expect = 3.994e-110 Identity = 169/359 (47.08%), Postives = 218/359 (60.72%), Query Frame = 1
Query: 955 TGWKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQNVN 2019
T + K +G + + +Y+ Y F GA + G+ + VF+ A+G L LA + KA+ A +++ ID+ +G P+ GN+EF+ + F YP R +V +LRGL L I G+TVA VG SGCGKST +QLL+R YDP QGQVL DG D K LN+ W+R+QI +V QEP LFN S+A+NI YG NS V + + + A ANIH FI LPE YNT VG +G LSGGQKQR+ IARAL KP ILLLDEATSALD SE VVQ ALD+A+ TCLV+ HRLS I+NAD IV++ NG + E GTH+EL+ R Y+ L N Q+V
Sbjct: 461 TQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPV------QGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ 812 HSP 2 Score: 107.071 bits (266), Expect = 3.994e-110 Identity = 88/334 (26.35%), Postives = 171/334 (51.20%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXX--XXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIK-DFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSN 976
+R+AD+IV +K+G + E+G H L+ +GLY+ ++ Q K ++ + S E KT + + + + S ++ + + +I + + ++++++++ E +++ G +A+ + G V P S+I+A++ +F + ++ +I G I + +AGE LT RLR ++L Q++A+FDE +N G LT LA++ + ++ A G ++ V + N+ S+ I F Y WE++ L L P +A+TG+++ TG Q L AG + E L NIRT+ SL+ + F Y + L+ + ++
Sbjct: 141 IRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFG--NNDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAG-----KIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 467 HSP 3 Score: 189.119 bits (479), Expect = 3.582e-50 Identity = 90/175 (51.43%), Postives = 128/175 (73.14%), Query Frame = 1
Query: 1477 LLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
++D +DI+ALN+ R+ IG+V QEP LF ++++NI YG + DV E M + A+ AN +DFI+ P +NT+VG++G +SGGQKQRI IARAL P IL+LDEATSALD++S+ VQ AL++A + T +V+AHRLSTI++AD IV +++G++ E G H EL+ RG YY L
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRD-DVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSL 174
BLAST of Multidrug resistance protein 1 vs. Ensembl Human
Match: ABCB5 (ATP binding cassette subfamily B member 5 [Source:HGNC Symbol;Acc:HGNC:46]) HSP 1 Score: 312.383 bits (799), Expect = 5.795e-110 Identity = 169/359 (47.08%), Postives = 218/359 (60.72%), Query Frame = 1
Query: 955 TGWKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQNVN 2019
T + K +G + + +Y+ Y F GA + G+ + VF+ A+G L LA + KA+ A +++ ID+ +G P+ GN+EF+ + F YP R +V +LRGL L I G+TVA VG SGCGKST +QLL+R YDP QGQVL DG D K LN+ W+R+QI +V QEP LFN S+A+NI YG NS V + + + A ANIH FI LPE YNT VG +G LSGGQKQR+ IARAL KP ILLLDEATSALD SE VVQ ALD+A+ TCLV+ HRLS I+NAD IV++ NG + E GTH+EL+ R Y+ L N Q+V
Sbjct: 906 TQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPD-TCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPV------QGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQSVQ 1257 HSP 2 Score: 107.071 bits (266), Expect = 5.795e-110 Identity = 88/334 (26.35%), Postives = 171/334 (51.20%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXX--XXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIK-DFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSN 976
+R+AD+IV +K+G + E+G H L+ +GLY+ ++ Q K ++ + S E KT + + + + S ++ + + +I + + ++++++++ E +++ G +A+ + G V P S+I+A++ +F + ++ +I G I + +AGE LT RLR ++L Q++A+FDE +N G LT LA++ + ++ A G ++ V + N+ S+ I F Y WE++ L L P +A+TG+++ TG Q L AG + E L NIRT+ SL+ + F Y + L+ + ++
Sbjct: 586 IRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQDIKKADEQMESMTYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFG--NNDKTTLKHDAEIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHAG-----KIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 912 HSP 3 Score: 278.87 bits (712), Expect = 4.201e-80 Identity = 148/341 (43.40%), Postives = 222/341 (65.10%), Query Frame = 1
Query: 1003 SGLAVSALYY----VYCVVFFVGAIFLDKGKTDMI--SLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
S +++ A+Y+ Y + F+ G + G+ +++ VF S+ +G A+ + AR AA Q ID+ +ID + G PE + G +EFKN+ F YP+R ++ +L+GL+L+I +G+TVALVG +G GKST++QLL+R YDP G +++D +DI+ALN+ R+ IG+V QEP LF ++++NI YG + DV E M + A+ AN +DFI+ P +NT+VG++G +SGGQKQRI IARAL P IL+LDEATSALD++S+ VQ AL++A + T +V+AHRLSTI++AD IV +++G++ E G H EL+ RG YY L
Sbjct: 287 SKVSLGAVYFFMNGTYGLAFWYGTSLILNGEPGYTIGTVLAVFFSVIHSSYCIGAAVPHFETFAIARGAAFHIFQVIDKKPSIDNFSTAGYKPE-SIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETVALVGLNGSGKSTVVQLLQRLYDP------DDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRD-DVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSL 619
BLAST of Multidrug resistance protein 1 vs. Ensembl Celegans
Match: pgp-2 (ABC transporter PGP-2; p-GlycoProtein related [Source:UniProtKB/TrEMBL;Acc:G5EDF9]) HSP 1 Score: 330.102 bits (845), Expect = 1.077e-118 Identity = 164/329 (49.85%), Postives = 227/329 (69.00%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELI 1974
G V + S ++++Y F++G+IF+++ I + RVF + +G S D KAR AA I+ T ID+ G+V + +TGNI +N+ F YPTR + VL+G L I AG+TVALVGHSGCGKST++ LLER+Y N +G +++DG +I+ LN+S +R Q+ +V QEP+LF+ ++ +NI YG+N +V Y+ +++ AKMANIH+FIL LP+GY+T VG++G LSGGQKQRI IARAL P +LLLDEATSALDT+SE +VQEALD A++ TCLVIAHRLSTI+N+D I I+ G +VE GTH+ELI
Sbjct: 957 GAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIV--KPITGNISIRNVFFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFY------NQDKGMIMIDGDNIRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELI 1277 HSP 2 Score: 117.472 bits (293), Expect = 1.077e-118 Identity = 98/349 (28.08%), Postives = 181/349 (51.86%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXX-----XXXSPESKTLTPTDAATRRLSSTANE-----EEFKLEKPSKIQMIKDFIR-----------------LMRISRMEG---GYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRL-STAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+RN D I V K G I+E G+HE L++ QG++++M + Q+ +++++ +S + + ++TR S A EE +L P Q +D IR + +I + G G+ I G+ A I G+V P +L+YAE++NV++L D M + + ++ G G T A CL + GE+LT +LR ++L+Q++A++D+ ++ G L R A +A V+ +L V + +IV + +L IGFYY W+L+L+ ++ +P + + G + ++ G+++ T + + + + +IRTV+SL+ Q+ F Y + L+
Sbjct: 599 IRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQEAGKDIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVELIDPFNGQTNQDVIRSRILSAFGGECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLP---ADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDLRHGTGKLCTRFATDAPNVRYVF-TRLPVVLASIVTICGALGIGFYYGWQLALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLR 943 HSP 3 Score: 288.5 bits (737), Expect = 7.165e-84 Identity = 152/345 (44.06%), Postives = 225/345 (65.22%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKT-DMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLN 2004
K ++G G + +Y Y + F+ G+ + T D + VF + +LG AL AR AA L+ I+ ID + +G++ + + G+I FK++HFRYP+R ++ VL+G+ L++ AG +ALVG SGCGKST++ LL+R+YDP +G+VL+DG D++ +N+ +R QIG+V QEP LF+ ++ +NI G N ++ +++ KMAN +DFI LP+GY T VG++G LSGGQKQRI IARAL P ILLLDEATSALDT++E VQ ALD+AQ T +++AHRLSTI+N D+I + + G +VESG+HEEL++ +G +YD+
Sbjct: 297 KYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVD-NMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDPT------KGRVLIDGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMG-NEHATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMT 633 HSP 4 Score: 81.2629 bits (199), Expect = 1.436e-15 Identity = 55/215 (25.58%), Postives = 109/215 (50.70%), Query Frame = 2
Query: 452 LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGI-MQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFWAALAA*PCQLCT-TSIALCFLSERFSWIKAKLI 1090
+ +L+ G ++ F + C E L +LR + ++L+Q++ +FD+ Q G LTARL + V+ G + ++ ++ A +GF+Y+W ++L+ + F P I L+G M ++T R+ + ++ E ++IRTV+SL+ D+++++L++ G+++ Y + + LC +S AL F W + LI
Sbjct: 122 IYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFDKQQT--GNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEV-GRQTGIVKYCYMGIGVGFSNLCMYSSYALAF------WYGSTLI 327
BLAST of Multidrug resistance protein 1 vs. Ensembl Celegans
Match: pgp-2 (ABC transporter PGP-2; p-GlycoProtein related [Source:UniProtKB/TrEMBL;Acc:G5EDF9]) HSP 1 Score: 330.102 bits (845), Expect = 1.305e-118 Identity = 164/329 (49.85%), Postives = 227/329 (69.00%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELI 1974
G V + S ++++Y F++G+IF+++ I + RVF + +G S D KAR AA I+ T ID+ G+V + +TGNI +N+ F YPTR + VL+G L I AG+TVALVGHSGCGKST++ LLER+Y N +G +++DG +I+ LN+S +R Q+ +V QEP+LF+ ++ +NI YG+N +V Y+ +++ AKMANIH+FIL LP+GY+T VG++G LSGGQKQRI IARAL P +LLLDEATSALDT+SE +VQEALD A++ TCLVIAHRLSTI+N+D I I+ G +VE GTH+ELI
Sbjct: 950 GAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIV--KPITGNISIRNVFFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFY------NQDKGMIMIDGDNIRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELI 1270 HSP 2 Score: 117.087 bits (292), Expect = 1.305e-118 Identity = 98/349 (28.08%), Postives = 181/349 (51.86%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXX-----XXXSPESKTLTPTDAATRRLSSTANE-----EEFKLEKPSKIQMIKDFIR-----------------LMRISRMEG---GYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRL-STAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+RN D I V K G I+E G+HE L++ QG++++M + Q+ +++++ +S + + ++TR S A EE +L P Q +D IR + +I + G G+ I G+ A I G+V P +L+YAE++NV++L D M + + ++ G G T A CL + GE+LT +LR ++L+Q++A++D+ ++ G L R A +A V+ +L V + +IV + +L IGFYY W+L+L+ ++ +P + + G + ++ G+++ T + + + + +IRTV+SL+ Q+ F Y + L+
Sbjct: 592 IRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQEAGKDIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVELIDPFNGQTNQDVIRSRILSAFGGECKAPPTSMFKIFKFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLP---ADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDLRHGTGKLCTRFATDAPNVRYVF-TRLPVVLASIVTICGALGIGFYYGWQLALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLR 936 HSP 3 Score: 288.886 bits (738), Expect = 5.937e-84 Identity = 152/345 (44.06%), Postives = 225/345 (65.22%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKT-DMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLN 2004
K ++G G + +Y Y + F+ G+ + T D + VF + +LG AL AR AA L+ I+ ID + +G++ + + G+I FK++HFRYP+R ++ VL+G+ L++ AG +ALVG SGCGKST++ LL+R+YDP +G+VL+DG D++ +N+ +R QIG+V QEP LF+ ++ +NI G N ++ +++ KMAN +DFI LP+GY T VG++G LSGGQKQRI IARAL P ILLLDEATSALDT++E VQ ALD+AQ T +++AHRLSTI+N D+I + + G +VESG+HEEL++ +G +YD+
Sbjct: 290 KYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVD-NMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDP------TKGRVLIDGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMG-NEHATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMT 626 HSP 4 Score: 81.2629 bits (199), Expect = 1.717e-15 Identity = 55/215 (25.58%), Postives = 109/215 (50.70%), Query Frame = 2
Query: 452 LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGI-MQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFWAALAA*PCQLCT-TSIALCFLSERFSWIKAKLI 1090
+ +L+ G ++ F + C E L +LR + ++L+Q++ +FD+ Q G LTARL + V+ G + ++ ++ A +GF+Y+W ++L+ + F P I L+G M ++T R+ + ++ E ++IRTV+SL+ D+++++L++ G+++ Y + + LC +S AL F W + LI
Sbjct: 115 IYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFDKQQT--GNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEV-GRQTGIVKYCYMGIGVGFSNLCMYSSYALAF------WYGSTLI 320
BLAST of Multidrug resistance protein 1 vs. Ensembl Celegans
Match: pgp-2 (ABC transporter PGP-2; p-GlycoProtein related [Source:UniProtKB/TrEMBL;Acc:G5EDF9]) HSP 1 Score: 330.487 bits (846), Expect = 2.712e-118 Identity = 164/329 (49.85%), Postives = 227/329 (69.00%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELI 1974
G V + S ++++Y F++G+IF+++ I + RVF + +G S D KAR AA I+ T ID+ G+V + +TGNI +N+ F YPTR + VL+G L I AG+TVALVGHSGCGKST++ LLER+Y N +G +++DG +I+ LN+S +R Q+ +V QEP+LF+ ++ +NI YG+N +V Y+ +++ AKMANIH+FIL LP+GY+T VG++G LSGGQKQRI IARAL P +LLLDEATSALDT+SE +VQEALD A++ TCLVIAHRLSTI+N+D I I+ G +VE GTH+ELI
Sbjct: 926 GAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIV--KPITGNISIRNVFFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFY------NQDKGMIMIDGDNIRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELI 1246 HSP 2 Score: 115.931 bits (289), Expect = 2.712e-118 Identity = 94/329 (28.57%), Postives = 176/329 (53.50%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXX-----XXXSPESKTLTPTDAATRRLSSTANE-----EEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRL-STAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+RN D I V K G I+E G+HE L++ QG++++M + Q+ +++++ +S + + ++TR S A EE + K M K F + + + G+ I G+ A I G+V P +L+YAE++NV++L D M + + ++ G G T A CL + GE+LT +LR ++L+Q++A++D+ ++ G L R A +A V+ +L V + +IV + +L IGFYY W+L+L+ ++ +P + + G + ++ G+++ T + + + + +IRTV+SL+ Q+ F Y + L+
Sbjct: 592 IRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQEAGKDIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVEECKAPPTSMFKIF----KFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLP---ADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDLRHGTGKLCTRFATDAPNVRYVF-TRLPVVLASIVTICGALGIGFYYGWQLALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLR 912 HSP 3 Score: 289.271 bits (739), Expect = 4.196e-84 Identity = 152/345 (44.06%), Postives = 225/345 (65.22%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKT-DMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLN 2004
K ++G G + +Y Y + F+ G+ + T D + VF + +LG AL AR AA L+ I+ ID + +G++ + + G+I FK++HFRYP+R ++ VL+G+ L++ AG +ALVG SGCGKST++ LL+R+YDP +G+VL+DG D++ +N+ +R QIG+V QEP LF+ ++ +NI G N ++ +++ KMAN +DFI LP+GY T VG++G LSGGQKQRI IARAL P ILLLDEATSALDT++E VQ ALD+AQ T +++AHRLSTI+N D+I + + G +VESG+HEEL++ +G +YD+
Sbjct: 290 KYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVD-NMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDP------TKGRVLIDGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMG-NEHATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMT 626 HSP 4 Score: 81.2629 bits (199), Expect = 1.388e-15 Identity = 55/215 (25.58%), Postives = 109/215 (50.70%), Query Frame = 2
Query: 452 LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGI-MQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFWAALAA*PCQLCT-TSIALCFLSERFSWIKAKLI 1090
+ +L+ G ++ F + C E L +LR + ++L+Q++ +FD+ Q G LTARL + V+ G + ++ ++ A +GF+Y+W ++L+ + F P I L+G M ++T R+ + ++ E ++IRTV+SL+ D+++++L++ G+++ Y + + LC +S AL F W + LI
Sbjct: 115 IYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFDKQQT--GNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEV-GRQTGIVKYCYMGIGVGFSNLCMYSSYALAF------WYGSTLI 320
BLAST of Multidrug resistance protein 1 vs. Ensembl Celegans
Match: pgp-2 (ABC transporter PGP-2; p-GlycoProtein related [Source:UniProtKB/TrEMBL;Acc:G5EDF9]) HSP 1 Score: 329.717 bits (844), Expect = 3.568e-118 Identity = 164/329 (49.85%), Postives = 227/329 (69.00%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELI 1974
G V + S ++++Y F++G+IF+++ I + RVF + +G S D KAR AA I+ T ID+ G+V + +TGNI +N+ F YPTR + VL+G L I AG+TVALVGHSGCGKST++ LLER+Y N +G +++DG +I+ LN+S +R Q+ +V QEP+LF+ ++ +NI YG+N +V Y+ +++ AKMANIH+FIL LP+GY+T VG++G LSGGQKQRI IARAL P +LLLDEATSALDT+SE +VQEALD A++ TCLVIAHRLSTI+N+D I I+ G +VE GTH+ELI
Sbjct: 933 GAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMIGNTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIV--KPITGNISIRNVFFNYPTRKDTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFY------NQDKGMIMIDGDNIRNLNISSLREQVCIVSQEPTLFDCTIGENICYGTNRNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLSGGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDVIAIVSEGKIVEKGTHDELI 1253 HSP 2 Score: 115.931 bits (289), Expect = 3.568e-118 Identity = 94/329 (28.57%), Postives = 176/329 (53.50%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXX-----XXXSPESKTLTPTDAATRRLSSTANE-----EEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRL-STAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+RN D I V K G I+E G+HE L++ QG++++M + Q+ +++++ +S + + ++TR S A EE + K M K F + + + G+ I G+ A I G+V P +L+YAE++NV++L D M + + ++ G G T A CL + GE+LT +LR ++L+Q++A++D+ ++ G L R A +A V+ +L V + +IV + +L IGFYY W+L+L+ ++ +P + + G + ++ G+++ T + + + + +IRTV+SL+ Q+ F Y + L+
Sbjct: 599 IRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQQQEAGKDIEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVEECKAPPTSMFKIF----KFNGDKVGWFIGGIFGAFIFGSVTPVFALVYAEIFNVYSLP---ADQMQANVYFWCGMFVLMGITFFVGFFTSANCLGRCGESLTMKLRFEAFKNLLRQDIAFYDDLRHGTGKLCTRFATDAPNVRYVF-TRLPVVLASIVTICGALGIGFYYGWQLALILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYLR 919 HSP 3 Score: 288.5 bits (737), Expect = 6.888e-84 Identity = 152/345 (44.06%), Postives = 225/345 (65.22%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKT-DMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLN 2004
K ++G G + +Y Y + F+ G+ + T D + VF + +LG AL AR AA L+ I+ ID + +G++ + + G+I FK++HFRYP+R ++ VL+G+ L++ AG +ALVG SGCGKST++ LL+R+YDP +G+VL+DG D++ +N+ +R QIG+V QEP LF+ ++ +NI G N ++ +++ KMAN +DFI LP+GY T VG++G LSGGQKQRI IARAL P ILLLDEATSALDT++E VQ ALD+AQ T +++AHRLSTI+N D+I + + G +VESG+HEEL++ +G +YD+
Sbjct: 297 KYCYMGIGVGFSNLCMYSSYALAFWYGSTLIINDPTFDRGLIFTVFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKIDPYSLEGILVD-NMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNLLQRFYDP------TKGRVLIDGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMG-NEHATHDQVVEACKMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREVQGALDQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMT 633 HSP 4 Score: 81.2629 bits (199), Expect = 1.391e-15 Identity = 55/215 (25.58%), Postives = 109/215 (50.70%), Query Frame = 2
Query: 452 LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGI-MQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFWAALAA*PCQLCT-TSIALCFLSERFSWIKAKLI 1090
+ +L+ G ++ F + C E L +LR + ++L+Q++ +FD+ Q G LTARL + V+ G + ++ ++ A +GF+Y+W ++L+ + F P I L+G M ++T R+ + ++ E ++IRTV+SL+ D+++++L++ G+++ Y + + LC +S AL F W + LI
Sbjct: 122 IYYLVLGVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFDKQQT--GNLTARLTDDLERVREGLGDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAGAIAEETFSSIRTVHSLNGHKRELDRFYNALEV-GRQTGIVKYCYMGIGVGFSNLCMYSSYALAF------WYGSTLI 327
BLAST of Multidrug resistance protein 1 vs. Ensembl Celegans
Match: pgp-1 (Multidrug resistance protein pgp-1 [Source:UniProtKB/Swiss-Prot;Acc:P34712]) HSP 1 Score: 307.375 bits (786), Expect = 1.980e-104 Identity = 161/340 (47.35%), Postives = 217/340 (63.82%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGA--IFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSN-SDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLN 2004
G G A S LY + + +G I D + ++RV T+ST+ LG A S + KA A + +++ ID+ ++KL G + FKN+ F YP R + +L+GL + GQT+ALVG SGCGKST++ LLER+YD G++ +DG +IK LN R+QI +V QEP+LF+ S+A+NIIYG + S V + + A++ANIH+FI LPEG+ T VG RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQEALDRA+E TC+VIAHRL+T+ NAD I ++ NG ++E GTH +L++ +G YY L
Sbjct: 980 GLSYGCASSVLYLLNTCAYRMGLALIITDPPTMQPMRVLRVMYAITISTSTLGFATSYFPEYAKATFAGGIIFGMLRKISKIDSLSLAGEKKKLYGKVIFKNVRFAYPERPEIEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTL------GGEIFIDGSEIKTLNPEHTRSQIAIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCIAVVSNGTIIEKGTHTQLMSEKGAYYKLT 1313 HSP 2 Score: 92.4337 bits (228), Expect = 1.980e-104 Identity = 56/208 (26.92%), Postives = 108/208 (51.92%), Query Frame = 2
Query: 353 FPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGX-XXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKS 973
+P S+ + NVFA P +S+G L+ L+ + + A E+LT LR + +VL Q + +FD PQN G ++ RLA + +++A + S I +V++ A + + F+Y W+++LL + +P +A ++G+ TG+ + +A S + +E + N+RTV +L+ +D F + + + L + K++
Sbjct: 768 YPTYSVFFTSFMNVFAGN---PADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLSQHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIAILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPHKEA 972 HSP 3 Score: 299.671 bits (766), Expect = 2.173e-90 Identity = 157/342 (45.91%), Postives = 219/342 (64.04%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH-KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K +FLG G ++ + + + F++G ++ G + ++ FS M + ALG A A+ AA + +DR ID+ K + K+ G+I +N+HF YP+R +V +LRG++L++NAGQTVALVG SGCGKST+I LL RYYD +G++ +DG D++ +NL ++R + +V QEP+LFN ++ +NI G + E M+ KMAN FI +LP GYNT+VG RG LSGGQKQRI IARAL P ILLLDEATSALD +SE +VQ+ALD+A + T ++IAHRLSTI+NAD I+ +NG VVE G H L+ +G YYDL
Sbjct: 315 KGLFLGISFGAMQASNFISFALAFYIGVGWVHDGSLNFGDMLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPVIDSSSKAGRKDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIISLLLRYYDVL------KGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEG-ITREEMVAACKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGIVQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDL 649 HSP 4 Score: 53.5286 bits (127), Expect = 2.173e-90 Identity = 42/143 (29.37%), Postives = 70/143 (48.95%), Query Frame = 2
Query: 488 GQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK-LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLS 913
GQ+T C + E + RLR + S+L+QE+++FD N G L +L VK G ++ + + + + F ++W+L+L+ L P AL G K +ST T + +V E +++IRTV SL+
Sbjct: 153 GQIT-VTCYLYVAEQMNNRLRREFVKSILRQEISWFD--TNHSGTLATKLFDNLERVKEGTGDKIGMAFQYLSQFITGFIVAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAGKVVEETISSIRTVVSLN 292
BLAST of Multidrug resistance protein 1 vs. Ensembl Fly
Match: Mdr50 (gene:FBgn0010241 transcript:FBtr0087537) HSP 1 Score: 278.87 bits (712), Expect = 1.328e-98 Identity = 147/340 (43.24%), Postives = 215/340 (63.24%), Query Frame = 1
Query: 988 FLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLT-GNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
F G V GLA S +++ Y + G + + +V M TA++ AL+ A + +K AA+ + R +I GV + + G + F + F YPTR+ + VL+GL+L ++ GQ +ALVG SGCGKST IQL++R+YD +G L+D D++ ++++ +RNQ+G+V QEP LF+ ++ +NI YG N+ +V + +I K +NIH+FI +LP GY+T +G++G LSGGQKQRI IARAL P I+LLDEATSALD +SE VVQ+ALD A E T + IAHRLST+ ++D I + ENG+V E+G H++L+ RG YY L
Sbjct: 972 FRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHSEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYD------VDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLANRGLYYTL 1305 HSP 2 Score: 102.449 bits (254), Expect = 1.328e-98 Identity = 91/353 (25.78%), Postives = 163/353 (46.18%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLS-STANEEEFKL--EKPSKIQMIKD-------------------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXXXX-XXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYF 991
VR AD IVV+ G+++E G H+ L+ + Y+ Q + L+PT + +EEE K+ E + M+ D + +M++++ E + G I++ I+G P ++++ + + ++K + L LI G ++ + + AGE LT RLR M ++L+QE+A+FD+ N G L ARL+ +A+ V+ A G ++ +++I L+ + + YY W L L+ L F P I + MQ L + + +A ++ + + +EV++NIRTV SL ++ F Y L + S N +F
Sbjct: 631 VRRADRIVVINKGEVVESGTHQELMELKDHYF----------NLVTTQLGEDDGSVLSPTGDIYKNFDIKDEDEEEIKVLSEDEDEDVMVTDEKNKKKKKKKVKDPNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDN-DQYVRENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEISKRNTHF 972 HSP 3 Score: 276.944 bits (707), Expect = 1.134e-79 Identity = 159/348 (45.69%), Postives = 216/348 (62.07%), Query Frame = 1
Query: 985 VFLGCVSGLAVSALYYVYCVVFFVGAIFLDKG-------KTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+F G GL +Y Y + F+ G + KG D +++ VF M + +G A + A+ A K I+++ I+ +G E LT IEFK + F+YPTR VS+L L+LKI+ GQTVALVG SGCGKST IQL++R+YDP G +L +G ++K L+++W+R++IG+V QEP LF S+ +NI YG D E + A AN FI LP+GY+T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT SE VQ AL++ T +++AHRLST++ AD+IV+I G VVESGTH+EL+ L+ HY++L
Sbjct: 325 MFSGIGFGLLWFFIYASYALAFWYGVGLVIKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPIDGEGKKLNEPLT-TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFYDPQA------GNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYG-REDATREEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNL 664
BLAST of Multidrug resistance protein 1 vs. Ensembl Fly
Match: Mdr49 (gene:FBgn0004512 transcript:FBtr0302198) HSP 1 Score: 269.626 bits (688), Expect = 5.458e-87 Identity = 154/348 (44.25%), Postives = 216/348 (62.07%), Query Frame = 1
Query: 973 KSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE---EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSN--SDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+ K+ F G V L +A + Y + + G I + + + + +++V + LG+AL+ A + A +A + + R T+ + P EK G+I ++N+ F YPTR +L+GL+L I TVALVG SG GKST +QLL RYYDP VS G V L G L +R+++GLV QEP LF+ ++A+NI YG+N DV + +I+ AK +NIH+FI +LP+GY+T +G + LSGGQKQRI IARAL P IL+LDEATSALD +SE VVQ+ALD A+ TCL IAHRL+T++NAD I +++ GVVVE GTH+EL+ L Y +L
Sbjct: 754 RRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKR-TSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDP-VS-----GSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANL 1093 HSP 2 Score: 72.7886 bits (177), Expect = 5.458e-87 Identity = 63/230 (27.39%), Postives = 128/230 (55.65%), Query Frame = 2
Query: 269 FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK--LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
F +LM+++ E +++ G IA+ + GA FP L + + + + L D++ ++ + ++ + G + G + + + AG +TTRLR +++ Q++AYFD+ +N G L +RLA + S V+ A G ++ ++A+ L + +GF ++W+ +LL L+ +P + L+ ++G+ + + Q+ + A +S + +E + NIRTVN L L+ D+Y +
Sbjct: 520 FTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGI--LSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQK-AKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQI 746 HSP 3 Score: 287.345 bits (734), Expect = 5.299e-84 Identity = 154/305 (50.49%), Postives = 196/305 (64.26%), Query Frame = 1
Query: 1099 LMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYG--SNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
L+ V M LG A + A A + IDR + +D KG PE G+I F+ + FRYP R +V +L+GL + + GQTVA VG SGCGKSTLIQL++R+YDP G V LDG D++ LN+ W+R+QIG+V QEP LF ++ +NI YG S + D E K A+ AN HDFI LP+GY+T VG++G +SGGQKQRI IARAL +P +LLLDEATSALD SE VQ AL+ A + T LV+AHRLSTI NADKIV +++GVV E GTHEEL+ RG Y +L
Sbjct: 140 LVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENT-AGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEA------GSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIE---KAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCEL 434
BLAST of Multidrug resistance protein 1 vs. Ensembl Fly
Match: Mdr49 (gene:FBgn0004512 transcript:FBtr0087801) HSP 1 Score: 269.24 bits (687), Expect = 7.602e-87 Identity = 154/348 (44.25%), Postives = 216/348 (62.07%), Query Frame = 1
Query: 973 KSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE---EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSN--SDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+ K+ F G V L +A + Y + + G I + + + + +++V + LG+AL+ A + A +A + + R T+ + P EK G+I ++N+ F YPTR +L+GL+L I TVALVG SG GKST +QLL RYYDP VS G V L G L +R+++GLV QEP LF+ ++A+NI YG+N DV + +I+ AK +NIH+FI +LP+GY+T +G + LSGGQKQRI IARAL P IL+LDEATSALD +SE VVQ+ALD A+ TCL IAHRL+T++NAD I +++ GVVVE GTH+EL+ L Y +L
Sbjct: 955 RRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKR-TSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDP-VS-----GSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANL 1294 HSP 2 Score: 72.4034 bits (176), Expect = 7.602e-87 Identity = 63/230 (27.39%), Postives = 128/230 (55.65%), Query Frame = 2
Query: 269 FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK--LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
F +LM+++ E +++ G IA+ + GA FP L + + + + L D++ ++ + ++ + G + G + + + AG +TTRLR +++ Q++AYFD+ +N G L +RLA + S V+ A G ++ ++A+ L + +GF ++W+ +LL L+ +P + L+ ++G+ + + Q+ + A +S + +E + NIRTVN L L+ D+Y +
Sbjct: 721 FTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGI--LSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQK-AKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQI 947 HSP 3 Score: 287.345 bits (734), Expect = 2.749e-83 Identity = 154/305 (50.49%), Postives = 196/305 (64.26%), Query Frame = 1
Query: 1099 LMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYG--SNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
L+ V M LG A + A A + IDR + +D KG PE G+I F+ + FRYP R +V +L+GL + + GQTVA VG SGCGKSTLIQL++R+YDP G V LDG D++ LN+ W+R+QIG+V QEP LF ++ +NI YG S + D E K A+ AN HDFI LP+GY+T VG++G +SGGQKQRI IARAL +P +LLLDEATSALD SE VQ AL+ A + T LV+AHRLSTI NADKIV +++GVV E GTHEEL+ RG Y +L
Sbjct: 341 LVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENT-AGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEA------GSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIE---KAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCEL 635
BLAST of Multidrug resistance protein 1 vs. Ensembl Fly
Match: Mdr65 (gene:FBgn0004513 transcript:FBtr0077011) HSP 1 Score: 291.197 bits (744), Expect = 1.226e-84 Identity = 157/352 (44.60%), Postives = 215/352 (61.08%), Query Frame = 1
Query: 970 IKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVP-----EEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIK-ALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLN 2004
I+ KL + G ++ ++ ++ Y V G + + +G+ +++V + L ++L+ A A + Q +DR I + G + + L + ++ + FRYPTR + +L GLDL++ GQTVALVGHSGCGKST +QLL+RYYDP +G + +D DI+ L L VR ++G+V QEP+LF S+A+NI YG N V +I AK AN H FI+SLP GY+T +G RG LSGGQKQRI IARAL P ILLLDEATSALD QSE +VQ+ALD A TC+VIAHRLST++NAD I +I+NG VVE G H +LI+ G Y L+
Sbjct: 951 IRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDP------DEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLH 1296 HSP 2 Score: 271.552 bits (693), Expect = 8.529e-78 Identity = 155/349 (44.41%), Postives = 210/349 (60.17%), Query Frame = 1
Query: 994 GCVSGLA---VSALYYVYCV-VFFVGAIFL-------DKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G SGL+ + ++ Y+ C F+ G + +K T I LM F + + R + AR A + ID + ID + G + L G++EF+++ FRYP+R V V RGL+++I AGQTVALVG SGCGKST +QLL+R+YDP G VLLD DI+ N+ W+R+ I +V QEP LF ++A NI YG E + A A H+FI +LPE Y +++G+RG LSGGQKQRI IARAL P ILLLDEATSALD QSE VQ+ALD A + T +V++HRLS I+ ADKIV I +G V+E G+H++L+ L G YY++
Sbjct: 298 GAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAI-LMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVF------GSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKE-IEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNM 638 HSP 3 Score: 104.76 bits (260), Expect = 9.317e-23 Identity = 90/298 (30.20%), Postives = 151/298 (50.67%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPES---KTL---------TPTDAATRRLSSTANEE------------EFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLT--KAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKL 817
+R AD IV + +GK++E+G+H+ L+ +G Y+ M+ +E ++E S E K+L +P + + +S EE + P K + F R++++++ E YLI G I+A VG ++P ++I+ E Y A K D + RT VL G L G + + + AG LTTR+R ++++ QE+ +FD+ N G L+ARL+ EA ++ A G LS I+A+ N +S+ + YYNW+L+LL L P I + I++ K+
Sbjct: 605 IRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEK----DPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKM 898
BLAST of Multidrug resistance protein 1 vs. Ensembl Fly
Match: CG10226 (gene:FBgn0035695 transcript:FBtr0332068) HSP 1 Score: 280.026 bits (715), Expect = 6.022e-81 Identity = 150/316 (47.47%), Postives = 204/316 (64.56%), Query Frame = 1
Query: 1060 AIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+I +D+ + +M V S +S + R + AR +A L IDR + ID + G + L G +EF+++ FRYP R +V VLRGL++ + GQTVALVG SGCGKST IQLL+R+YDP GQVLLDG D++ N+ W+R+ I +V QEP LF S+ +NI +G + + + AK AN HDFI++L +GY+T + ++G LSGGQ+QRI IARAL +P ILLLDEATSALD SE +VQ ALD+A + T LV++HRLS I++A +IV IENG VE GTHEEL+ L G Y+ +
Sbjct: 225 SIPIDEREYTPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKGAVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVF------GQVLLDGEDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHG-KPEATQKEVEDAAKAANAHDFIIALHKGYDTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVVSHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKM 533 HSP 2 Score: 276.174 bits (705), Expect = 1.506e-79 Identity = 154/357 (43.14%), Postives = 216/357 (60.50%), Query Frame = 1
Query: 967 KIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGN----------IEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIK-ALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+I S+L + G V+ L S +++ Y V G GK ++M++ + L ++L+ A +A + + IDR I + + ++ G + ++ L+F YP+R ++ VL+ +L IN GQTVALVG SG GKST +QLL RYYDP +G++L+D I ++L +R ++G+V QEPSLF S+ADNI YG S V + +I+ AKMAN H+FI+SLP Y+TV+G +G LSGGQKQRI IARA+ P ILLLDEATSALD QSE VVQ+ALD A TC+VIAHRLSTI+NA+ I +I+ G +VE G+H +L+ G Y L
Sbjct: 848 QILSRLKWRGLVNSLGKSLMFFGYAVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQIQSPESFEIQQNGNGTAYKTNVVQQGVSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASGSGKSTCVQLLMRYYDP------DEGKILIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDTSRQVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLDEATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNGIYSKL 1198 HSP 3 Score: 92.0485 bits (227), Expect = 9.278e-19 Identity = 84/300 (28.00%), Postives = 140/300 (46.67%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXX---------XXXXXXSPESKTLTPTDAATRR-LSSTANEEEFKLEK------------------PSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKL 817
+R+A IV ++NGK +EQG HE L+ +G Y +M+ + + + S + P TR + S EF+++ PS I F R++ +R E +LI G I A + G P S++ AELY A K T +++ + ++ ++ L+ G + + AG LTTR+R+ ++ QEM +FD +N G L+ARL+ +A+ V+ A G LS I+A N S+ I F Y+WEL+L+ L P + + + + +
Sbjct: 500 IRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAEELLNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSA-NFISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLA-KPTDEEVL-EQSASMAIISLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAASVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARF 796
BLAST of Multidrug resistance protein 1 vs. Ensembl Zebrafish
Match: abcb5 (ATP-binding cassette, sub-family B (MDR/TAP), member 5 [Source:ZFIN;Acc:ZDB-GENE-030131-6414]) HSP 1 Score: 330.102 bits (845), Expect = 5.380e-119 Identity = 175/352 (49.72%), Postives = 234/352 (66.48%), Query Frame = 1
Query: 955 TGWKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
T +K K G LA + Y V +F GA + T+ ++ VFS + +G++ S A D KA+ AA + +Q +++ ID + G P +GNI+FK++ F YPTR NV VL+GL++ + GQT+ALVG SGCGKST IQLLER+YDP GQVL+DG D K++NL+W+R Q+GLV QEP LF+ ++++NI YG NS V E + + AK ANIH+FIL+LP+ YNT VG +G LSGGQKQRI IARAL KP +LLLDEATSALDT+SE +VQ ALD A+ TC+VIAHRL+TI+NAD IV+++NG VVE GTH +L+ + Y+ L
Sbjct: 986 TPYKASLCKAPIYGITFALAQAIPYLVNAAIFRFGAWLIAHCYTEYENVFLVFSVIVFAAMNIGQSSSFAPDFAKAKAAAGRIIQLLEKKPEIDIYDESGERPS-TFSGNIDFKDVQFSYPTRPNVKVLQGLNVSVRQGQTLALVGSSGCGKSTTIQLLERFYDP------AGGQVLVDGRDSKSVNLAWLRTQMGLVSQEPILFDCTISENIQYGDNSRTVTQEEIEEAAKKANIHNFILTLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRKPKLLLLDEATSALDTESEKIVQAALDEARLGRTCIVIAHRLTTIQNADIIVVVQNGKVVEQGTHAQLMAKQEAYFAL 1330 HSP 2 Score: 119.398 bits (298), Expect = 5.380e-119 Identity = 98/362 (27.07%), Postives = 181/362 (50.00%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEE------EFKLEKPS---------------------------KIQMIKD--FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLV--LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQ-RLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKS 973
+R+ADII G+++EQG+H L+ +G+Y+ ++ Q ++ E+ + T D+ +++ E E KLE+ S K + I + F +++ +++ + YL+ G A+ + GAV+PC ++++A++ VFA PD + + +T++ LL+L+ G + + + K+GE LT RLR+ ++++QE+ +FD+ N G+LT +LA +ASLVK AAG +L + I L ++ + F + W+L+LL L +P + +Q + + G + S + E + N +TV +L+ +D F K+ DSL K S
Sbjct: 638 IRSADIIAGFSEGRVVEQGSHRELMAKKGVYYSLVTQQTSGRQNEELDANEDD----TQDDSEEETGEDSSDPEILEGGVEMKLERGSFRKSLKRSSKRRSSRKKSKKSRKDKKAKKEEIPEMPFTKILALNKPDWPYLVVGTFASLVGGAVYPCVAILFAKIIGVFAE----PDPEVKRQKTMMFSLLYLLIGVVAFLTYFFQGFMFGKSGELLTMRLRSQAFKAIVRQEIGWFDDNNNAVGILTTKLATDASLVKGAAGSRLGLATNTICALLIAVIVAFVFCWQLTLLILACVPFLTGANFIQLRATAGHTSKDQSALEMSGKISTETVENFKTVVALTREDVFFHKFIDSLSTPYKAS 991 HSP 3 Score: 302.753 bits (774), Expect = 1.731e-88 Identity = 165/344 (47.97%), Postives = 225/344 (65.41%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGA-IFLDKGKTDMIS-LMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSN--SDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN 2019
GL ++ Y + F+ G + +D+ + I ++ VF + T +LG+ + KAR AA + +TID ID+ +G P+ ++ G+IEFKN++F YP+R +V++L+G+ LK+ G+T+ALVG SGCGKST IQLL+R+YDP G+V LDGHDI++LN+ W+R +G+V QEP LF ++A+NI YG +D D E IK AN +DFI LP+ NT+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDTQSE +VQ ALD+A+ T +VIAHRLSTI++AD I G VVE G+H EL+ +G YY L Q +
Sbjct: 344 GLTQFIVFATYALAFWYGTKLSVDEPENYTIGRVLTVFFSVMIGTFSLGQGAPNLEAIAKARGAAYEVYKTIDMPRPIDSSSKEGHKPD-RVRGDIEFKNINFNYPSRKDVTILQGMSLKVPHGKTIALVGASGCGKSTTIQLLQRFYDP------DSGEVTLDGHDIRSLNVRWLRENMGIVSQEPVLFGTTIAENIRYGREDATDADIEQAIK---EANAYDFISKLPDKLNTMVGERGAQLSGGQKQRIAIARALVKNPKILLLDEATSALDTQSESIVQAALDKARAGRTTIVIAHRLSTIRSADIIAGFSEGRVVEQGSHRELMAKKGVYYSLVTQQTS 677 HSP 4 Score: 51.2174 bits (121), Expect = 4.848e-6 Identity = 32/118 (27.12%), Postives = 61/118 (51.69%), Query Frame = 2
Query: 464 IPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKL 817
I G +L+ G L+ A + T R+R ++L Q+M++FD + G L RL + + + G +++VF++ + + L IGF + W+L+L+ L P +A + + K+
Sbjct: 165 IGGAVLVLGTFQVMLFLLTAAKQ-TKRIRQKYFHAILHQQMSWFD--THPIGELNIRLTDDINTINDGLGDKIAVFVQFFCSFISGLVIGFVFGWKLTLVILAVSPLLAGSAAVWSKI 279
BLAST of Multidrug resistance protein 1 vs. Ensembl Zebrafish
Match: abcb5 (ATP-binding cassette, sub-family B (MDR/TAP), member 5 [Source:ZFIN;Acc:ZDB-GENE-030131-6414]) HSP 1 Score: 329.717 bits (844), Expect = 7.378e-119 Identity = 175/352 (49.72%), Postives = 234/352 (66.48%), Query Frame = 1
Query: 955 TGWKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
T +K K G LA + Y V +F GA + T+ ++ VFS + +G++ S A D KA+ AA + +Q +++ ID + G P +GNI+FK++ F YPTR NV VL+GL++ + GQT+ALVG SGCGKST IQLLER+YDP GQVL+DG D K++NL+W+R Q+GLV QEP LF+ ++++NI YG NS V E + + AK ANIH+FIL+LP+ YNT VG +G LSGGQKQRI IARAL KP +LLLDEATSALDT+SE +VQ ALD A+ TC+VIAHRL+TI+NAD IV+++NG VVE GTH +L+ + Y+ L
Sbjct: 998 TPYKASLCKAPIYGITFALAQAIPYLVNAAIFRFGAWLIAHCYTEYENVFLVFSVIVFAAMNIGQSSSFAPDFAKAKAAAGRIIQLLEKKPEIDIYDESGERPS-TFSGNIDFKDVQFSYPTRPNVKVLQGLNVSVRQGQTLALVGSSGCGKSTTIQLLERFYDP------AGGQVLVDGRDSKSVNLAWLRTQMGLVSQEPILFDCTISENIQYGDNSRTVTQEEIEEAAKKANIHNFILTLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRKPKLLLLDEATSALDTESEKIVQAALDEARLGRTCIVIAHRLTTIQNADIIVVVQNGKVVEQGTHAQLMAKQEAYFAL 1342 HSP 2 Score: 119.398 bits (298), Expect = 7.378e-119 Identity = 98/362 (27.07%), Postives = 181/362 (50.00%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEE------EFKLEKPS---------------------------KIQMIKD--FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLV--LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQ-RLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKS 973
+R+ADII G+++EQG+H L+ +G+Y+ ++ Q ++ E+ + T D+ +++ E E KLE+ S K + I + F +++ +++ + YL+ G A+ + GAV+PC ++++A++ VFA PD + + +T++ LL+L+ G + + + K+GE LT RLR+ ++++QE+ +FD+ N G+LT +LA +ASLVK AAG +L + I L ++ + F + W+L+LL L +P + +Q + + G + S + E + N +TV +L+ +D F K+ DSL K S
Sbjct: 650 IRSADIIAGFSEGRVVEQGSHRELMAKKGVYYSLVTQQTSGRQNEELDANEDD----TQDDSEEETGEDSSDPEILEGGVEMKLERGSFRKSLKRSSKRRSSRKKSKKSRKDKKAKKEEIPEMPFTKILALNKPDWPYLVVGTFASLVGGAVYPCVAILFAKIIGVFAE----PDPEVKRQKTMMFSLLYLLIGVVAFLTYFFQGFMFGKSGELLTMRLRSQAFKAIVRQEIGWFDDNNNAVGILTTKLATDASLVKGAAGSRLGLATNTICALLIAVIVAFVFCWQLTLLILACVPFLTGANFIQLRATAGHTSKDQSALEMSGKISTETVENFKTVVALTREDVFFHKFIDSLSTPYKAS 1003 HSP 3 Score: 302.368 bits (773), Expect = 2.574e-88 Identity = 165/344 (47.97%), Postives = 225/344 (65.41%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGA-IFLDKGKTDMIS-LMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSN--SDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN 2019
GL ++ Y + F+ G + +D+ + I ++ VF + T +LG+ + KAR AA + +TID ID+ +G P+ ++ G+IEFKN++F YP+R +V++L+G+ LK+ G+T+ALVG SGCGKST IQLL+R+YDP G+V LDGHDI++LN+ W+R +G+V QEP LF ++A+NI YG +D D E IK AN +DFI LP+ NT+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDTQSE +VQ ALD+A+ T +VIAHRLSTI++AD I G VVE G+H EL+ +G YY L Q +
Sbjct: 356 GLTQFIVFATYALAFWYGTKLSVDEPENYTIGRVLTVFFSVMIGTFSLGQGAPNLEAIAKARGAAYEVYKTIDMPRPIDSSSKEGHKPD-RVRGDIEFKNINFNYPSRKDVTILQGMSLKVPHGKTIALVGASGCGKSTTIQLLQRFYDP------DSGEVTLDGHDIRSLNVRWLRENMGIVSQEPVLFGTTIAENIRYGREDATDADIEQAIK---EANAYDFISKLPDKLNTMVGERGAQLSGGQKQRIAIARALVKNPKILLLDEATSALDTQSESIVQAALDKARAGRTTIVIAHRLSTIRSADIIAGFSEGRVVEQGSHRELMAKKGVYYSLVTQQTS 689 HSP 4 Score: 50.8322 bits (120), Expect = 5.470e-6 Identity = 32/118 (27.12%), Postives = 61/118 (51.69%), Query Frame = 2
Query: 464 IPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKL 817
I G +L+ G L+ A + T R+R ++L Q+M++FD + G L RL + + + G +++VF++ + + L IGF + W+L+L+ L P +A + + K+
Sbjct: 177 IGGAVLVLGTFQVMLFLLTAAKQ-TKRIRQKYFHAILHQQMSWFD--THPIGELNIRLTDDINTINDGLGDKIAVFVQFFCSFISGLVIGFVFGWKLTLVILAVSPLLAGSAAVWSKI 291
BLAST of Multidrug resistance protein 1 vs. Ensembl Zebrafish
Match: abcb11a (ATP-binding cassette, sub-family B (MDR/TAP), member 11a [Source:ZFIN;Acc:ZDB-GENE-050517-13]) HSP 1 Score: 303.523 bits (776), Expect = 8.499e-119 Identity = 158/338 (46.75%), Postives = 211/338 (62.43%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE-EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G A ++ Y F G + + + RV S S ALGRA S D KA+ +A + Q +DR+ I+ K G +EFK F YP+R +V VLRGL + ++ GQT+A VG SGCGKST +QLLER+YDP +GQVL+DG ++++ ++R+QIG+V QEP LF+ S+A+NI YG NS V E +I AK A +HDF+++LP+ Y T VG +G LS GQKQRI IARA+ P ILLLDEATSALDT+SE VQ ALD A++ TC+VIAHRLSTI++AD I ++ G V+E GTH+EL+ + YY L
Sbjct: 981 GICFAFARCVIFMAYAASFRYGGYLVSHEGLQYMMVFRVISALVTSATALGRASSFTPDYAKAKISAAQLFQLLDRVPKINVSKTEGQSWNDFKGKVEFKGCRFTYPSRPDVQVLRGLVVSVHPGQTLAFVGSSGCGKSTSVQLLERFYDP------DEGQVLIDGRPSDSISVPFLRSQIGIVSQEPVLFDCSIAENIQYGDNSRTVSMEEIIDAAKKAYLHDFVMTLPDKYETQVGAQGSQLSRGQKQRIAIARAIVRNPKILLLDEATSALDTESEKTVQAALDEARQGRTCIVIAHRLSTIQSADIIAVMSQGEVIEKGTHDELMAKKAAYYKL 1312 HSP 2 Score: 145.206 bits (365), Expect = 8.499e-119 Identity = 104/363 (28.65%), Postives = 182/363 (50.14%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTA--------------------------------------NEEEFKLE-----KPSKIQMIKDF-----IRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHF 928
+RNAD+IV ++G+ +E+G H LL+ +G+Y+ ++ Q + ++ T P + A R++ A N + F++E K SK + +D R+++ +R E Y++ G I A+I G++ P +L+++++ F++ PD + + +L ++ G + F Q + + K+GE LT RLR F ++LKQE+ +FD+P N PG LT RLA AS+V+ A G Q+ + + ++ N+ AS I +Y++W+LSL+ F+P I L+G+ Q K+ TG L AG + E ++NIRT+ L+ + HF
Sbjct: 613 IRNADVIVGFEHGRAVERGTHSQLLDKKGVYFTLVTLQNQ----------GKDTDTDKPENTAESRVTEEAELEELRRFSSGSYESVLRRRSLSQLSNSLSVISGKFDFNSDLFEMEESDNNKKSKGKAKEDIKPAPVARILKYNRPEWPYMLLGSIGAAINGSLNPMYALLFSQILGTFSIPD--PDDQRRQINGICILFVVIGVVSFFSQFLQGYSFAKSGELLTRRLRKFGFQAMLKQEIGWFDDPMNSPGALTTRLATNASMVQGATGSQIGMIVNSLTNIGASFIIAYYFSWKLSLVVTCFLPLIGLSGVFQSKMLTGLANEDKTALEAAG-----QVSSEAMSNIRTIAGLAKEKHF 958 HSP 3 Score: 261.536 bits (667), Expect = 4.324e-74 Identity = 154/338 (45.56%), Postives = 219/338 (64.79%), Query Frame = 1
Query: 1030 YVYCVVFFVGAIFLDKGKTDMIS--------LMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE-EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQN 2013
Y++C++F A+ G +I L++VF + LG+A + R AA+ TIDR ID +K+ G+IEF +++F YP+R V +L L++ + AG+T A VG SG GK+T IQL++R+YDP +G V LDGHDI++LN+ W+R+ IG+V+QEP LF ++A+NI YG + V + +I+ AK AN ++FI+SLP+ ++T+VG+ GG +SGGQKQRI IARAL P ILLLD ATSALD +SE VVQEALD+A++ T + IAHRLSTI+NAD IV E+G VE GTH +L++ +G Y+ L +QN
Sbjct: 321 YLWCIIFLCYALAFWFGSKLVIETQELTPGGLVQVFFGVLIGAMNLGQASPCLEAFASGRAAAKSIFDTIDREPEIDCFSDEGHTLDKVKGDIEFHSVNFNYPSRPEVKILDDLNIVVKAGETTAFVGPSGSGKTTTIQLIQRFYDP------SEGMVSLDGHDIRSLNIQWLRSLIGVVEQEPVLFATTIAENIRYG-RAGVTMQEIIEAAKQANAYNFIMSLPQTFDTLVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAVVQEALDKARQGRTTISIAHRLSTIRNADVIVGFEHGRAVERGTHSQLLDKKGVYFTLVTLQN 651
BLAST of Multidrug resistance protein 1 vs. Ensembl Zebrafish
Match: abcb11a (ATP-binding cassette, sub-family B (MDR/TAP), member 11a [Source:ZFIN;Acc:ZDB-GENE-050517-13]) HSP 1 Score: 303.523 bits (776), Expect = 1.091e-118 Identity = 158/338 (46.75%), Postives = 211/338 (62.43%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE-EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G A ++ Y F G + + + RV S S ALGRA S D KA+ +A + Q +DR+ I+ K G +EFK F YP+R +V VLRGL + ++ GQT+A VG SGCGKST +QLLER+YDP +GQVL+DG ++++ ++R+QIG+V QEP LF+ S+A+NI YG NS V E +I AK A +HDF+++LP+ Y T VG +G LS GQKQRI IARA+ P ILLLDEATSALDT+SE VQ ALD A++ TC+VIAHRLSTI++AD I ++ G V+E GTH+EL+ + YY L
Sbjct: 938 GICFAFARCVIFMAYAASFRYGGYLVSHEGLQYMMVFRVISALVTSATALGRASSFTPDYAKAKISAAQLFQLLDRVPKINVSKTEGQSWNDFKGKVEFKGCRFTYPSRPDVQVLRGLVVSVHPGQTLAFVGSSGCGKSTSVQLLERFYDP------DEGQVLIDGRPSDSISVPFLRSQIGIVSQEPVLFDCSIAENIQYGDNSRTVSMEEIIDAAKKAYLHDFVMTLPDKYETQVGAQGSQLSRGQKQRIAIARAIVRNPKILLLDEATSALDTESEKTVQAALDEARQGRTCIVIAHRLSTIQSADIIAVMSQGEVIEKGTHDELMAKKAAYYKL 1269 HSP 2 Score: 144.821 bits (364), Expect = 1.091e-118 Identity = 104/363 (28.65%), Postives = 182/363 (50.14%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTA--------------------------------------NEEEFKLE-----KPSKIQMIKDF-----IRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHF 928
+RNAD+IV ++G+ +E+G H LL+ +G+Y+ ++ Q + ++ T P + A R++ A N + F++E K SK + +D R+++ +R E Y++ G I A+I G++ P +L+++++ F++ PD + + +L ++ G + F Q + + K+GE LT RLR F ++LKQE+ +FD+P N PG LT RLA AS+V+ A G Q+ + + ++ N+ AS I +Y++W+LSL+ F+P I L+G+ Q K+ TG L AG + E ++NIRT+ L+ + HF
Sbjct: 570 IRNADVIVGFEHGRAVERGTHSQLLDKKGVYFTLVTLQNQ----------GKDTDTDKPENTAESRVTEEAELEELRRFSSGSYESVLRRRSLSQLSNSLSVISGKFDFNSDLFEMEESDNNKKSKGKAKEDIKPAPVARILKYNRPEWPYMLLGSIGAAINGSLNPMYALLFSQILGTFSIPD--PDDQRRQINGICILFVVIGVVSFFSQFLQGYSFAKSGELLTRRLRKFGFQAMLKQEIGWFDDPMNSPGALTTRLATNASMVQGATGSQIGMIVNSLTNIGASFIIAYYFSWKLSLVVTCFLPLIGLSGVFQSKMLTGLANEDKTALEAAG-----QVSSEAMSNIRTIAGLAKEKHF 915 HSP 3 Score: 261.536 bits (667), Expect = 3.505e-74 Identity = 154/338 (45.56%), Postives = 219/338 (64.79%), Query Frame = 1
Query: 1030 YVYCVVFFVGAIFLDKGKTDMIS--------LMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE-EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQN 2013
Y++C++F A+ G +I L++VF + LG+A + R AA+ TIDR ID +K+ G+IEF +++F YP+R V +L L++ + AG+T A VG SG GK+T IQL++R+YDP +G V LDGHDI++LN+ W+R+ IG+V+QEP LF ++A+NI YG + V + +I+ AK AN ++FI+SLP+ ++T+VG+ GG +SGGQKQRI IARAL P ILLLD ATSALD +SE VVQEALD+A++ T + IAHRLSTI+NAD IV E+G VE GTH +L++ +G Y+ L +QN
Sbjct: 278 YLWCIIFLCYALAFWFGSKLVIETQELTPGGLVQVFFGVLIGAMNLGQASPCLEAFASGRAAAKSIFDTIDREPEIDCFSDEGHTLDKVKGDIEFHSVNFNYPSRPEVKILDDLNIVVKAGETTAFVGPSGSGKTTTIQLIQRFYDP------SEGMVSLDGHDIRSLNIQWLRSLIGVVEQEPVLFATTIAENIRYG-RAGVTMQEIIEAAKQANAYNFIMSLPQTFDTLVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAVVQEALDKARQGRTTISIAHRLSTIRNADVIVGFEHGRAVERGTHSQLLDKKGVYFTLVTLQN 608
BLAST of Multidrug resistance protein 1 vs. Ensembl Zebrafish
Match: abcb11b (ATP-binding cassette, sub-family B (MDR/TAP), member 11b [Source:ZFIN;Acc:ZDB-GENE-050517-14]) HSP 1 Score: 287.345 bits (734), Expect = 3.499e-104 Identity = 162/340 (47.65%), Postives = 219/340 (64.41%), Query Frame = 1
Query: 988 FLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH-KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
F CV +A SA Y F G + +G + RV S S ALGRA S D KA+ +A + Q +DR+ I + K + G+IEF + F YP+R ++ VL GL++ + GQT+A VG SGCGKST +QLLER+YDP G+VL+DG + +N++++R++IG+V QEP LF+ S+A+NI YG N ++ +I AK A +HDF++SLPE Y+T VG +G LS GQKQRI IARA+ P ILLLDEATSALDT+SE VQEALD+A+E TC+VIAHRLSTI+N+D I ++ G V+E GTH+ L+ L+G YY L
Sbjct: 945 FAQCVVFMANSASYR------FGGYLVYHEG-LHFSFVFRVISAIVTSGTALGRASSYTPDYAKAKISAARFFQLLDRIPKISVYSKDGQKWDNFKGDIEFIDCKFTYPSRPDIQVLNGLNVSVKPGQTLAFVGSSGCGKSTSVQLLERFYDP------NSGRVLIDGRESSQINVAYLRSKIGIVSQEPILFDCSIAENIRYGDNQRELSMNDVISAAKKAQLHDFVMSLPEKYDTNVGSQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKTVQEALDKAREGRTCIVIAHRLSTIQNSDIIAVMSRGYVIEKGTHDYLMGLKGAYYKL 1271 HSP 2 Score: 112.464 bits (280), Expect = 3.499e-104 Identity = 98/365 (26.85%), Postives = 170/365 (46.58%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLL-------------------------------------------NHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFK-----LEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRT--LVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHF 928
++NAD+IV ++G+ +E+G H+ LL N G Y L + ++ + PES + R S T +EF E ++ R+++ + E Y+ G I A++ G V P SL+++++ F++ PD + + + L ++ G + F Q+ + + K+GE LT RLR ++L QE+ +FD+ +N PG LT RLA +AS V+ A G Q+ + + ++ N+ ++ I FY++W+L+L+ L F+P +AL+G Q K+ TG + + TAG + E LNNIRT+ L + +F
Sbjct: 562 IKNADVIVGFEHGRAVERGKHDELLERKGVYFTLVTLQSQGDKALNQKAQQEMEEAECCDSDAERRSLNRAGSYRASLRASIHQRSRSQLSNAVPESSVAIAGELGPRSYSETTVPQEFMGKSGVPEDTAEEVEPAPVARILKYNAPEWPYMFFGSIGAAVNGGVNPVYSLLFSQILATFSM----PDPVEQRREINGICLFFVVVGLVSFFTQMLQGYAFSKSGELLTRRLRRLGFQAMLGQEIGWFDDRKNSPGALTTRLATDASQVQGATGSQIGMIVNSLTNIGVAVIISFYFSWKLTLVILCFLPFLALSGGFQAKMLTGFAKQDKEAMETAG-----QISGEALNNIRTIAGLGKERNF 917 HSP 3 Score: 256.144 bits (653), Expect = 2.283e-72 Identity = 152/343 (44.31%), Postives = 217/343 (63.27%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGA-IFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA-HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K + +G +G ++ Y + F+ G+ + +D + +L++VF ++ LG+A + R AA +TIDR ID + +K+ G++EF N+ F YP+R V +L L+L++ +G+T A VG SG GKST IQL++R+YDP +G + LDGHDI+ LN+ W+R+ IG+V+QEP LF ++A+NI YG V + +I AK AN ++FI+ LP+ + T+VG+ GG +SGGQKQRI IARAL P ILLLD ATSALD +SE VVQEALD+ + T + IAHRLSTIKNAD IV E+G VE G H+EL+ +G Y+ L
Sbjct: 260 KGLIMGFFTGYMWFIIFLCYALAFWYGSSLVVDTQEYSPGTLLQVFFGVLIAALNLGQASPCLEAFAAGRGAATIIFETIDREPEIDCLSEAGYKLDKVKGDLEFHNITFHYPSRPEVKILDQLNLQVKSGETTAFVGPSGAGKSTAIQLIQRFYDP------KEGMLTLDGHDIRGLNIQWLRSLIGIVEQEPVLFATTIAENIRYG-RPGVSNDDIITAAKEANAYNFIMDLPQKFETLVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAVVQEALDKVRMGRTTISIAHRLSTIKNADVIVGFEHGRAVERGKHDELLERKGVYFTL 595
BLAST of Multidrug resistance protein 1 vs. Ensembl Xenopus
Match: gjc2 (gap junction protein gamma 2 [Source:Xenbase;Acc:XB-GENE-968864]) HSP 1 Score: 340.502 bits (872), Expect = 3.566e-122 Identity = 172/346 (49.71%), Postives = 234/346 (67.63%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSD-VDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQNVN 2019
G L+ S +Y+ Y F G + L+ G+T+ L+ VF+ T ++G++LS A D KA+ AA +R AID++ +G PE G++E + + F YP+R +V VL+GL +KI +GQTVA VG SGCGKST +QLL+R+YDP+ QG VL D D K LN+ W+R+QI +V QEP LF+ S+A+NI YG NS V E + + AK ANIH FI LPE YNT VG +G LSGGQKQRI IARAL KP +LLLDEATSALD +SE +VQ+ALD+A++ TC++IAHRLST++NAD IV+++NG ++E G H++L+ RG Y+DL N Q +
Sbjct: 848 GICFALSQSFIYFSYAATFRFGGLMLELGRTNSEELILVFAIVTYGAMSVGQSLSFAPDYSKAKSAASHLFALFEREPAIDSYCQQGQKPE-TFQGSVELRKVSFNYPSRPDVPVLQGLSIKIQSGQTVAFVGSSGCGKSTSVQLLQRFYDPY------QGDVLFDNLDAKCLNIQWLRSQIAIVSQEPVLFDCSIAENIAYGDNSRAVPMEEIQRAAKAANIHSFIEGLPEKYNTKVGGKGTQLSGGQKQRIAIARALVRKPKLLLLDEATSALDNESEKIVQQALDQARQGRTCILIAHRLSTVQNADVIVVMKNGRIIELGNHQQLLAKRGTYFDLVNAQTIT 1186 HSP 2 Score: 120.168 bits (300), Expect = 3.566e-122 Identity = 96/339 (28.32%), Postives = 169/339 (49.85%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIK----DFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLY 988
V AD+IVV++NG + EQG H+ L+ +G+Y ++ Q+ S L + +RLSS + LE+ + + F +++ +++ E Y++ G +AA I G P + +A++ VF+ P+ + + ++ + G I + + ++GE LT R+R ++L+QEM++FD+ +N G LT RLA +AS ++ A G +L + E + + S+ I F Y WEL+LL L P I +TG+++ TG + L AG + E ++NIRTV SL+ + F + Y +SL+ + +Y
Sbjct: 528 VWTADVIVVIENGAVAEQGTHKELMEKKGIYHSLVTAQVH------------NSPFLDQKPSLVKRLSSKISTRSEHLEEEEEKEDESLPKVSFFKILNLNKSEWPYILIGTLAAIINGGAHPAFCIFFAKVSAVFST--NDPERIQREANLYSIIFAVIGVISFLTYFLQGFMFGRSGEVLTMRVRQMAFKAMLRQEMSWFDDKKNSTGALTTRLATDASQIQMATGSRLGLIAENVACMGLSVIIAFVYGWELTLLILAMTPFIIVTGLLETSALTGFANRDKKELQVAG-----KIAAETVDNIRTVISLTRERAFEEMYAESLQKPYRSVRAQVY 847 HSP 3 Score: 306.605 bits (784), Expect = 2.898e-90 Identity = 174/354 (49.15%), Postives = 234/354 (66.10%), Query Frame = 1
Query: 1000 VSGLAVSALY-YVYC---VVFFVGAIFL--DKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN*SYFFN 2037
VS LA+ ++ ++YC + F+ G I + +KG T +L+ FS S+ +G+A S + AR AA K +D+ ID + +G PE + GN+EFKN+ F YP+R NV +L+GL+LKI +GQTVALVG SGCGKST +QLL+R YD +G V +DGHDI++LN+ R IG+V QEP LF ++ +NI YG + D E + K K AN +DFI++LP+ Y+T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ+AL++A T +VIAHRLST+ AD IV+IENG V E GTH+EL+ +G Y+ L V+ S F +
Sbjct: 229 VSQLALGLVFLFIYCSYGLGFWYGTIVILQNKGYTIGDALVIFFSV-ANSSFCIGQASSHFEAFSIARGAAYKIFNVMDQTATIDNYMTEGHRPE-NMKGNVEFKNVSFSYPSRPNVQILKGLNLKIKSGQTVALVGQSGCGKSTTVQLLQRLYDA------QEGTVTVDGHDIRSLNVGHYREFIGVVSQEPVLFGTTIKNNIKYGRENVTDLE-IEKAVKEANAYDFIMALPDKYDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQDALEKASAGRTTIVIAHRLSTVWTADVIVVIENGAVAEQGTHKELMEKKGIYHSLVTAQVHNSPFLD 573
BLAST of Multidrug resistance protein 1 vs. Ensembl Xenopus
Match: mia2 (MIA SH3 domain ER export factor 2 [Source:Xenbase;Acc:XB-GENE-993630]) HSP 1 Score: 327.02 bits (837), Expect = 1.025e-121 Identity = 168/339 (49.56%), Postives = 226/339 (66.67%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G L+ + +Y+ Y F GA + + + VFS ALG+ S A D KA +A ++R+ ID++ +G P+ GN++F+ + F YPTR +++VL+GLD+ + G+T+ALVG SGCGKST + LLER+YDP+ G+VL+DGH ++ LN+ WVR Q+G+V QEP LF+ S+ +NI YG NS +V + AK ANIH FI +L + YNT VG +G +SGGQKQRI IARAL KP ILLLDEATSALDT+SE VVQEALD+A+ TC+VIAHRLSTI+NADKI +I+NG VVE GTH++L+ L+G YY L
Sbjct: 927 GLTYALSQAIMYFAYAGCFRFGAYLVAELLMTPDDVFLVFSAIVFGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPLIDSYSKEGEKPQN-CGGNVQFQGVQFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPF------GGEVLVDGHSVRDLNIQWVRAQMGIVSQEPILFDCSIGENIAYGDNSREVTQAEIETAAKEANIHSFIDTLTDKYNTRVGDKGTQMSGGQKQRIAIARALVRKPKILLLDEATSALDTESEKVVQEALDKARTGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYYTL 1258 HSP 2 Score: 131.724 bits (330), Expect = 1.025e-121 Identity = 107/331 (32.33%), Postives = 177/331 (53.47%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXS-PESKTLT------PTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+RNAD+I NG I+EQG H+ L++ G+Y+ ++ Q+ + E + P S T + + ++++ T N+EE + P + F+++MR+++ E Y + G+I A I GA P ++I++++ VFA M +K LL L G I + + KAGE LT RLR + S+L+QE+ +FD+ +N G LT RLA +AS V+ A G +L++ + I NL ++ I F Y W L+LL L +P IA + ++Q K+ G + L AG +S+ +++ NIRTV SL+ + F Y +L+
Sbjct: 598 IRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNLVTLQVGKPNLELNLSEKIPLSHTSSNLVRRKSSRHTIKKVTETDNKEE---DGPPPVS----FLKVMRLNKTEWPYFVVGIICAMINGATQPAFAIIFSKIIGVFAGP---ASEMRAKSTMYSLLFLALGGISFITFFLQGFTFGKAGEILTKRLRLWSFKSMLRQEIGWFDDTKNSTGALTTRLATDASQVQGATGSRLALLAQNIANLGTAVIISFIYGWRLTLLILAIVPIIAASALVQLKMFAGHAKKDKKELEKAGKISTDAVL-----NIRTVVSLTRERKFEAMYEKNLE 913 HSP 3 Score: 309.301 bits (791), Expect = 8.073e-93 Identity = 165/349 (47.28%), Postives = 228/349 (65.33%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVS-GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K+I K VS G A +Y Y + F+ G + G + S++ VF + A+G+ + AR AA ID ID+ +G+ P+ K+ G+IEFKN+ F YP+R ++ VL+GL+L I +G+TVALVG SGCGKST +QL++R+YDP +G + LDG DI++LN+ ++R IG+V QEP LF+ ++ADNI YG DV E + + K AN ++FI+ LP+ + T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +V+AHRLSTI+NAD I +NGV+VE G H+EL++ G Y++L
Sbjct: 291 KRIGIKKAITANVSIGFAFLMIYAAYALAFWYGTTLIINGGYTIGSVLTVFFAVIIGAFAVGQTSPNVEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPD-KIKGDIEFKNVKFTYPSRTDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDP------EEGVITLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYG-REDVTMEEIERATKEANAYNFIMKLPDKFETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKAREGRTTIVVAHRLSTIRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNL 631 HSP 4 Score: 53.1434 bits (126), Expect = 8.073e-93 Identity = 44/164 (26.83%), Postives = 82/164 (50.00%), Query Frame = 2
Query: 470 GF-ILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK-LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
GF +LLF + ++ + AG+ + R+R+ +VL+QE+ +FD N G L RL + S + G ++++ ++++ IGF W+L+L+ L P + + + K LS + ++ EVL++IRTV + QD +Y +L+
Sbjct: 128 GFGVLLFAYVQISFWTLSAGKQIK-RIRSNFFHAVLRQEIGWFD--VNDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTFVTGFIIGFVKGWKLTLVILAISPVMGFSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQDKEIKRYEKNLE 288
BLAST of Multidrug resistance protein 1 vs. Ensembl Xenopus
Match: mia2 (MIA SH3 domain ER export factor 2 [Source:Xenbase;Acc:XB-GENE-993630]) HSP 1 Score: 327.791 bits (839), Expect = 1.200e-121 Identity = 168/339 (49.56%), Postives = 226/339 (66.67%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G L+ + +Y+ Y F GA + + + VFS ALG+ S A D KA +A ++R+ ID++ +G P+ GN++F+ + F YPTR +++VL+GLD+ + G+T+ALVG SGCGKST + LLER+YDP+ G+VL+DGH ++ LN+ WVR Q+G+V QEP LF+ S+ +NI YG NS +V + AK ANIH FI +L + YNT VG +G +SGGQKQRI IARAL KP ILLLDEATSALDT+SE VVQEALD+A+ TC+VIAHRLSTI+NADKI +I+NG VVE GTH++L+ L+G YY L
Sbjct: 945 GLTYALSQAIMYFAYAGCFRFGAYLVAELLMTPDDVFLVFSAIVFGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPLIDSYSKEGEKPQ-NCGGNVQFQGVQFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPF------GGEVLVDGHSVRDLNIQWVRAQMGIVSQEPILFDCSIGENIAYGDNSREVTQAEIETAAKEANIHSFIDTLTDKYNTRVGDKGTQMSGGQKQRIAIARALVRKPKILLLDEATSALDTESEKVVQEALDKARTGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYYTL 1276 HSP 2 Score: 130.954 bits (328), Expect = 1.200e-121 Identity = 109/339 (32.15%), Postives = 178/339 (52.51%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXS-------PESKTLT------PTDAATRRLSSTANEEEFKLEKPSKIQMIK--DFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+RNAD+I NG I+EQG H+ L++ G+Y+ ++ Q E ++ ++ L P S T + + ++++ T N+EE E K F+++MR+++ E Y + G+I A I GA P ++I++++ VFA M +K LL L G I + + KAGE LT RLR + S+L+QE+ +FD+ +N G LT RLA +AS V+ A G +L++ + I NL ++ I F Y W L+LL L +P IA + ++Q K+ G + L AG +S+ +++ NIRTV SL+ + F Y +L+
Sbjct: 601 IRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNLVTLQTVETSKDTEENLELNLSEKIPLSHTSSNLVRRKSSRHTIKKVTETDNKEEVDEEGKKKEDGPPPVSFLKVMRLNKTEWPYFVVGIICAMINGATQPAFAIIFSKIIGVFAGP---ASEMRAKSTMYSLLFLALGGISFITFFLQGFTFGKAGEILTKRLRLWSFKSMLRQEIGWFDDTKNSTGALTTRLATDASQVQGATGSRLALLAQNIANLGTAVIISFIYGWRLTLLILAIVPIIAASALVQLKMFAGHAKKDKKELEKAGKISTDAVL-----NIRTVVSLTRERKFEAMYEKNLE 931 HSP 3 Score: 310.071 bits (793), Expect = 5.284e-93 Identity = 165/349 (47.28%), Postives = 228/349 (65.33%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVS-GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K+I K VS G A +Y Y + F+ G + G + S++ VF + A+G+ + AR AA ID ID+ +G+ P+ K+ G+IEFKN+ F YP+R ++ VL+GL+L I +G+TVALVG SGCGKST +QL++R+YDP +G + LDG DI++LN+ ++R IG+V QEP LF+ ++ADNI YG DV E + + K AN ++FI+ LP+ + T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +V+AHRLSTI+NAD I +NGV+VE G H+EL++ G Y++L
Sbjct: 294 KRIGIKKAITANVSIGFAFLMIYAAYALAFWYGTTLIINGGYTIGSVLTVFFAVIIGAFAVGQTSPNVEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPD-KIKGDIEFKNVKFTYPSRTDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDP------EEGVITLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYG-REDVTMEEIERATKEANAYNFIMKLPDKFETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKAREGRTTIVVAHRLSTIRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNL 634 HSP 4 Score: 53.5286 bits (127), Expect = 5.284e-93 Identity = 44/164 (26.83%), Postives = 82/164 (50.00%), Query Frame = 2
Query: 470 GF-ILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK-LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
GF +LLF + ++ + AG+ + R+R+ +VL+QE+ +FD N G L RL + S + G ++++ ++++ IGF W+L+L+ L P + + + K LS + ++ EVL++IRTV + QD +Y +L+
Sbjct: 131 GFGVLLFAYVQISFWTLSAGKQIK-RIRSNFFHAVLRQEIGWFD--VNDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTFVTGFIIGFVKGWKLTLVILAISPVMGFSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQDKEIKRYEKNLE 291
BLAST of Multidrug resistance protein 1 vs. Ensembl Xenopus
Match: mia2 (MIA SH3 domain ER export factor 2 [Source:Xenbase;Acc:XB-GENE-993630]) HSP 1 Score: 327.405 bits (838), Expect = 1.466e-121 Identity = 168/339 (49.56%), Postives = 226/339 (66.67%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G L+ + +Y+ Y F GA + + + VFS ALG+ S A D KA +A ++R+ ID++ +G P+ GN++F+ + F YPTR +++VL+GLD+ + G+T+ALVG SGCGKST + LLER+YDP+ G+VL+DGH ++ LN+ WVR Q+G+V QEP LF+ S+ +NI YG NS +V + AK ANIH FI +L + YNT VG +G +SGGQKQRI IARAL KP ILLLDEATSALDT+SE VVQEALD+A+ TC+VIAHRLSTI+NADKI +I+NG VVE GTH++L+ L+G YY L
Sbjct: 929 GLTYALSQAIMYFAYAGCFRFGAYLVAELLMTPDDVFLVFSAIVFGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPLIDSYSKEGEKPQ-NCGGNVQFQGVQFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPF------GGEVLVDGHSVRDLNIQWVRAQMGIVSQEPILFDCSIGENIAYGDNSREVTQAEIETAAKEANIHSFIDTLTDKYNTRVGDKGTQMSGGQKQRIAIARALVRKPKILLLDEATSALDTESEKVVQEALDKARTGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYYTL 1260 HSP 2 Score: 131.339 bits (329), Expect = 1.466e-121 Identity = 107/331 (32.33%), Postives = 175/331 (52.87%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXS-PESKTLT------PTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+RNAD+I NG I+EQG H+ L++ G+Y+ ++ Q+ + E + P S T + + ++++ T N+EE P F+++MR+++ E Y + G+I A I GA P ++I++++ VFA M +K LL L G I + + KAGE LT RLR + S+L+QE+ +FD+ +N G LT RLA +AS V+ A G +L++ + I NL ++ I F Y W L+LL L +P IA + ++Q K+ G + L AG +S+ +++ NIRTV SL+ + F Y +L+
Sbjct: 599 IRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNLVTLQVGKPNLELNLSEKIPLSHTSSNLVRRKSSRHTIKKVTETDNKEEEDGPPPV------SFLKVMRLNKTEWPYFVVGIICAMINGATQPAFAIIFSKIIGVFAGP---ASEMRAKSTMYSLLFLALGGISFITFFLQGFTFGKAGEILTKRLRLWSFKSMLRQEIGWFDDTKNSTGALTTRLATDASQVQGATGSRLALLAQNIANLGTAVIISFIYGWRLTLLILAIVPIIAASALVQLKMFAGHAKKDKKELEKAGKISTDAVL-----NIRTVVSLTRERKFEAMYEKNLE 915 HSP 3 Score: 309.301 bits (791), Expect = 8.073e-93 Identity = 165/349 (47.28%), Postives = 228/349 (65.33%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVS-GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K+I K VS G A +Y Y + F+ G + G + S++ VF + A+G+ + AR AA ID ID+ +G+ P+ K+ G+IEFKN+ F YP+R ++ VL+GL+L I +G+TVALVG SGCGKST +QL++R+YDP +G + LDG DI++LN+ ++R IG+V QEP LF+ ++ADNI YG DV E + + K AN ++FI+ LP+ + T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +V+AHRLSTI+NAD I +NGV+VE G H+EL++ G Y++L
Sbjct: 292 KRIGIKKAITANVSIGFAFLMIYAAYALAFWYGTTLIINGGYTIGSVLTVFFAVIIGAFAVGQTSPNVEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPD-KIKGDIEFKNVKFTYPSRTDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDP------EEGVITLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYG-REDVTMEEIERATKEANAYNFIMKLPDKFETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKAREGRTTIVVAHRLSTIRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNL 632 HSP 4 Score: 53.1434 bits (126), Expect = 8.073e-93 Identity = 44/164 (26.83%), Postives = 82/164 (50.00%), Query Frame = 2
Query: 470 GF-ILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK-LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
GF +LLF + ++ + AG+ + R+R+ +VL+QE+ +FD N G L RL + S + G ++++ ++++ IGF W+L+L+ L P + + + K LS + ++ EVL++IRTV + QD +Y +L+
Sbjct: 129 GFGVLLFAYVQISFWTLSAGKQIK-RIRSNFFHAVLRQEIGWFD--VNDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTFVTGFIIGFVKGWKLTLVILAISPVMGFSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQDKEIKRYEKNLE 289
BLAST of Multidrug resistance protein 1 vs. Ensembl Xenopus
Match: mia2 (MIA SH3 domain ER export factor 2 [Source:Xenbase;Acc:XB-GENE-993630]) HSP 1 Score: 327.405 bits (838), Expect = 1.579e-121 Identity = 168/339 (49.56%), Postives = 226/339 (66.67%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G L+ + +Y+ Y F GA + + + VFS ALG+ S A D KA +A ++R+ ID++ +G P+ GN++F+ + F YPTR +++VL+GLD+ + G+T+ALVG SGCGKST + LLER+YDP+ G+VL+DGH ++ LN+ WVR Q+G+V QEP LF+ S+ +NI YG NS +V + AK ANIH FI +L + YNT VG +G +SGGQKQRI IARAL KP ILLLDEATSALDT+SE VVQEALD+A+ TC+VIAHRLSTI+NADKI +I+NG VVE GTH++L+ L+G YY L
Sbjct: 925 GLTYALSQAIMYFAYAGCFRFGAYLVAELLMTPDDVFLVFSAIVFGAMALGQTSSFAPDYTKAMISAAHIFSLLERVPLIDSYSKEGEKPQ-NCGGNVQFQGVQFNYPTRPDITVLQGLDISVKQGETLALVGSSGCGKSTTVSLLERFYDPF------GGEVLVDGHSVRDLNIQWVRAQMGIVSQEPILFDCSIGENIAYGDNSREVTQAEIETAAKEANIHSFIDTLTDKYNTRVGDKGTQMSGGQKQRIAIARALVRKPKILLLDEATSALDTESEKVVQEALDKARTGRTCIVIAHRLSTIQNADKIAVIQNGKVVEQGTHQQLLQLKGVYYTL 1256 HSP 2 Score: 130.954 bits (328), Expect = 1.579e-121 Identity = 108/337 (32.05%), Postives = 179/337 (53.12%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXS-------PESKTLT------PTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+RNAD+I NG I+EQG H+ L++ G+Y+ ++ Q E ++ ++ L P S T + + ++++ T N+EE + P + F+++MR+++ E Y + G+I A I GA P ++I++++ VFA M +K LL L G I + + KAGE LT RLR + S+L+QE+ +FD+ +N G LT RLA +AS V+ A G +L++ + I NL ++ I F Y W L+LL L +P IA + ++Q K+ G + L AG +S+ +++ NIRTV SL+ + F Y +L+
Sbjct: 590 IRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNLVTLQTVETSKDTEENLELNLSEKIPLSHTSSNLVRRKSSRHTIKKVTETDNKEE---DGPPPVS----FLKVMRLNKTEWPYFVVGIICAMINGATQPAFAIIFSKIIGVFAGP---ASEMRAKSTMYSLLFLALGGISFITFFLQGFTFGKAGEILTKRLRLWSFKSMLRQEIGWFDDTKNSTGALTTRLATDASQVQGATGSRLALLAQNIANLGTAVIISFIYGWRLTLLILAIVPIIAASALVQLKMFAGHAKKDKKELEKAGKISTDAVL-----NIRTVVSLTRERKFEAMYEKNLE 911 HSP 3 Score: 309.301 bits (791), Expect = 6.781e-93 Identity = 165/349 (47.28%), Postives = 228/349 (65.33%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVS-GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K+I K VS G A +Y Y + F+ G + G + S++ VF + A+G+ + AR AA ID ID+ +G+ P+ K+ G+IEFKN+ F YP+R ++ VL+GL+L I +G+TVALVG SGCGKST +QL++R+YDP +G + LDG DI++LN+ ++R IG+V QEP LF+ ++ADNI YG DV E + + K AN ++FI+ LP+ + T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +V+AHRLSTI+NAD I +NGV+VE G H+EL++ G Y++L
Sbjct: 283 KRIGIKKAITANVSIGFAFLMIYAAYALAFWYGTTLIINGGYTIGSVLTVFFAVIIGAFAVGQTSPNVEAFANARGAAYTIFNIIDNQPKIDSFSKEGLKPD-KIKGDIEFKNVKFTYPSRTDIQVLKGLNLNIPSGKTVALVGSSGCGKSTTVQLIQRFYDP------EEGVITLDGQDIRSLNIRYLREIIGVVSQEPILFDTTIADNIRYG-REDVTMEEIERATKEANAYNFIMKLPDKFETLVGERGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKAREGRTTIVVAHRLSTIRNADVIAGFDNGVIVEQGGHKELMDKGGVYFNL 623 HSP 4 Score: 53.5286 bits (127), Expect = 6.781e-93 Identity = 44/164 (26.83%), Postives = 82/164 (50.00%), Query Frame = 2
Query: 470 GF-ILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK-LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
GF +LLF + ++ + AG+ + R+R+ +VL+QE+ +FD N G L RL + S + G ++++ ++++ IGF W+L+L+ L P + + + K LS + ++ EVL++IRTV + QD +Y +L+
Sbjct: 120 GFGVLLFAYVQISFWTLSAGKQIK-RIRSNFFHAVLRQEIGWFD--VNDAGELNTRLTDDVSKINEGIGDKIAMLLQSLTTFVTGFIIGFVKGWKLTLVILAISPVMGFSAAIWAKVLSAFTNKELKAYAKAGAVAEEVLSSIRTVFAFGGQDKEIKRYEKNLE 280
BLAST of Multidrug resistance protein 1 vs. Ensembl Mouse
Match: Abcb4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4 [Source:MGI Symbol;Acc:MGI:97569]) HSP 1 Score: 336.265 bits (861), Expect = 2.164e-122 Identity = 174/343 (50.73%), Postives = 233/343 (67.93%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
G ++ + +Y+ Y F G+ + G ++ VFS + ALG A S A D KA+ +A +R ID++ +G+ P+ K G++ F + F YPTRANV VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP G VLLDG + K LN+ W+R Q+G+V QEP LF+ S+A+NI YG NS V ++ +++ AK ANIH FI +LP+ YNT VG +G LSGGQKQRI IARAL +P +LLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+IENG V E GTH++L+ +G Y+ + N+Q
Sbjct: 935 GITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPD-KFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMA------GSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVNIQ 1270 HSP 2 Score: 124.405 bits (311), Expect = 2.164e-122 Identity = 95/337 (28.19%), Postives = 169/337 (50.15%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSST--ANEEEFKLEKPSKIQMIKD------------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
+RNAD+I ++G I+EQG+H L+ +G+Y+ ++ Q + ++ S D A + N + L+ P + ++ ++ F++++++++ E Y + G + A GA+ P S+I +E+ +F +LV L L G + F + + KAGE LTTRLR+ ++L+Q+M++FD+ +N G L+ RLA +A+ V+ A G +L++ + NL + I F Y W+L+LL L +P IA+ GI++ K+ G + + AG + E + NIRTV SL+ + F Y + L
Sbjct: 591 IRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRLVNMQTAGSQILSEEFEVELSDEKAAGDVAPNGWKARIFRNSTKKSLKSPHQNRLDEETNELDANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVKQQKCNMFSLVFLGL--GVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAG-----KIATEAIENIRTVVSLTQERKFESMYVEKL 920 HSP 3 Score: 300.442 bits (768), Expect = 8.807e-88 Identity = 164/353 (46.46%), Postives = 227/353 (64.31%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVS-GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
KKI K +S G+A +Y Y + F+ G+ + + + + M VF + ++G+A AR AA ID ID+ +G P+ + GN+EF ++HF YP+RAN+ +L+GL+LK+ +GQTVALVG+SGCGKST +QLL+R YDP +G++ +DG DI+ N+ +R IG+V QEP LF+ ++A+NI YG +V + + K K AN +DFI+ LP+ ++T+VG RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VQ ALD+A+E T +VIAHRLSTI+NAD I E+GV+VE G+H EL+ G Y+ L N+Q
Sbjct: 284 KKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-NIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDP------TEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYG-RGNVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRLVNMQ 628
BLAST of Multidrug resistance protein 1 vs. Ensembl Mouse
Match: Abcb5 (ATP-binding cassette, sub-family B (MDR/TAP), member 5 [Source:MGI Symbol;Acc:MGI:1924956]) HSP 1 Score: 307.375 bits (786), Expect = 2.019e-111 Identity = 161/339 (47.49%), Postives = 213/339 (62.83%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSD-VDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
GC ++ + +++ + F GA + G+ + VF+ A+G L A + KA+ A + I++ G P+ GN+EF+ + F YP R V VL+ + L I G+TVA VG SGCGKST +QLL+R+YDP +GQVLLDG D+K LN+ W+R+Q +V QEP LFN S+A+NI YG NS V E + +VA ANIH FI LP YNT+VG RG LSGGQKQR+ IARAL KP ILLLDEATSALD +SE VVQ+ALD+A+ TCLV+AHRLSTI+NAD IV+++NG + E GTH+EL+ Y+ L
Sbjct: 920 GCCYAVSHAFVHFAHAAGFRFGAYLIQAGRMMPEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGASHLFALLKNKPTINSCSQSGEKPD-TCEGNLEFREVSFVYPCRPEVPVLQNMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPM------KGQVLLDGVDVKELNVQWLRSQTAIVSQEPVLFNCSIAENIAYGDNSRMVPLEEIKEVADAANIHSFIEGLPRKYNTLVGLRGVQLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKVVQQALDKARRGKTCLVVAHRLSTIQNADMIVVLQNGSIKEQGTHQELLRNGDTYFKL 1251 HSP 2 Score: 116.701 bits (291), Expect = 2.019e-111 Identity = 95/333 (28.53%), Postives = 171/333 (51.35%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPT---------DAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+R AD+IV MK+G ++E+G H L+ QGLY+ + Q +K +E+ ES+T + D + + T EE + + + + +++ ++S+ E +++ G +A+++ G+V P S+I+ +L +F K + ++ ++ G + L L + +A E L RLR ++L Q+MA++D+ +N G LT LAV+ + ++ AA +L + + + N+S S+ I F Y WE++LL L F P +A+TG++Q G Q L AG + E + NIRTV SL+ + F Y ++L+
Sbjct: 587 IRGADLIVTMKDGMVVEKGTHAELMAKQGLYYSLAMAQDIKKVDEQM-----ESRTCSTAGNASYGSLCDVNSAKAPCTDQLEEAVHHQKTSLPEV-SLLKIFKLSKSEWPFVVLGTLASALNGSVHPVFSIIFGKLVTMFEDKNKAT--LKQDAELYSMMLVVLGIVALVTYLMQGLFYGRAEENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTTLAVDVAQIQGAATSRLGIVTQDVSNMSLSILISFIYGWEMTLLILSFAPVLAVTGMIQTAAMAGFANRDKQALKRAG-----KIATEAVENIRTVVSLTRERAFEQMYEETLQ 906 HSP 3 Score: 282.337 bits (721), Expect = 1.547e-81 Identity = 157/341 (46.04%), Postives = 220/341 (64.52%), Query Frame = 1
Query: 1003 SGLAVSALYY----VYCVVFFVGA--IFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
S L++ A+Y+ Y + F+ G IF + + +++ VF S+ +G + AR AA Q ID+ ID + G VPE + GNIEFKN+ F YP+R + VL+GL+LKI AG+TVALVG SG GKST +QLL+R YDP G + +D +DI+A N+ R QIG+V+QEP LF ++ +NI +G V + M + A+ AN +DFI++ P+ +NT+VG++G +SGGQKQRI IARAL P IL+LDEATSALDT+SE +VQ AL++A + T +V+AHRLSTI+ AD IV +++G+VVE GTH EL+ +G YY L
Sbjct: 288 SKLSLGAVYFFMNGAYGLAFWYGTSLIFGGEPGYTIGTILAVFFSVIHSSYCIGSVAPHLETFTVARGAAFNIFQVIDKKPNIDNFSTAGFVPE-CIEGNIEFKNVSFSYPSRPSAKVLKGLNLKIKAGETVALVGPSGSGKSTTVQLLQRLYDP------EDGCITVDENDIRAQNVRHYREQIGVVRQEPVLFGTTIGNNIKFGREG-VGEKEMEQAAREANAYDFIMAFPKKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDTESESLVQTALEKASKGRTTIVVAHRLSTIRGADLIVTMKDGMVVEKGTHAELMAKQGLYYSL 620
BLAST of Multidrug resistance protein 1 vs. Ensembl Mouse
Match: Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A [Source:MGI Symbol;Acc:MGI:97570]) HSP 1 Score: 335.495 bits (859), Expect = 2.038e-100 Identity = 171/340 (50.29%), Postives = 229/340 (67.35%), Query Frame = 1
Query: 991 LGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G + +Y+ Y F GA + + +++ VFS A+G+ S A D KA +A ++ I++ ID++ +G+ P L GN++F + F YPTR ++ VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP G V LDG +IK LN+ W+R Q+G+V QEP LF+ S+A+NI YG NS V YE +++ AK ANIH FI SLP+ YNT VG +G LSGGQKQRI IARAL +P ILLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+I+NG V E GTH++L+ +G Y+ +
Sbjct: 934 FGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPN-MLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMA------GSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSM 1266 HSP 2 Score: 301.982 bits (772), Expect = 2.327e-88 Identity = 156/333 (46.85%), Postives = 217/333 (65.17%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH-KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G A +Y Y + F+ G + + + ++ VF + ++G+A + AR AA + + ID +ID+ K + + GN+EFKN+HF YP+R V +L+GL+LK+ +GQTVALVG+SGCGKST +QL++R YDP G V +DG DI+ +N+ ++R IG+V QEP LF ++A+NI YG DV + + K K AN +DFI+ LP ++T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +VIAHRLST++NAD I + GV+VE G H+EL+ +G Y+ L
Sbjct: 296 GAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPL------DGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYG-REDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKL 621 HSP 3 Score: 136.346 bits (342), Expect = 1.542e-32 Identity = 110/369 (29.81%), Postives = 184/369 (49.86%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAAT--------RRLSSTA-----NEEEFKLEKPSKIQMIKD-----FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGX-XXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFWAALAA*PCQLCTTSIALCF 1051
VRNAD+I G I+EQGNH+ L+ +G+Y++++ Q + E E + D ++ RR S+ ++++ KL +K + +D F R+++++ E Y + G+ A I G + P S+I++++ VF P+ LL LI G I + + KAGE LT RLR + S+L+Q++++FD+P+N G LT RLA +A+ VK A G +L+V + I NL + I Y W+L+LL L +P IA+ G+++ K+ +GQ L S + E + N RTV SL+ + F Y SL++ + + + + + + S A CF
Sbjct: 588 VRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKL--STKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFT-NGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAACF 953
BLAST of Multidrug resistance protein 1 vs. Ensembl Mouse
Match: Abcb1b (ATP-binding cassette, sub-family B (MDR/TAP), member 1B [Source:MGI Symbol;Acc:MGI:97568]) HSP 1 Score: 335.109 bits (858), Expect = 2.418e-100 Identity = 172/340 (50.59%), Postives = 227/340 (66.76%), Query Frame = 1
Query: 991 LGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSD-VDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G + +Y+ Y F GA + + ++M VFS A G S A D KA+ +A ++ I++ ID++ +G+ P L GN++F + F YPTR N+ VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP G V LDG +IK LN+ W+R +G+V QEP LF+ S+A+NI YG NS V +E +++ AK ANIH FI SLP+ YNT VG +G LSGGQKQRI IARAL +P ILLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+IENG V E GTH++L+ +G Y+ +
Sbjct: 936 FGITFSFTQAMMYFSYAACFRFGAYLVAQQLMTFENVMLVFSAVVFGAMAAGNTSSFAPDYAKAKVSASHIIRIIEKTPEIDSYSTEGLKPT-LLEGNVKFNGVQFNYPTRPNIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMA------GSVFLDGKEIKQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRAVSHEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSM 1268 HSP 2 Score: 305.834 bits (782), Expect = 9.399e-90 Identity = 158/334 (47.31%), Postives = 221/334 (66.17%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G+A +Y Y + F+ G + + + ++ VF + T ++G + AR AA + + ID +ID+ KG P+ + GN+EFKN+HF YP+R+ V +L+GL+LK+ +GQTVALVG+SGCGKST +QL++R YDP +G V +DG DI+ +N+ ++R IG+V QEP LF ++A+NI YG DV + + K K AN +DFI+ LP ++T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +VIAHRLST++NAD I + GV+VE G H+EL+ +G Y+ L
Sbjct: 299 GIAYLLVYASYALAFWYGTSLVLSNEYSIGEVLTVFFSILLGTFSIGHLAPNIEAFANARGAAFEIFKIIDNEPSIDSFSTKGYKPD-SIMGNLEFKNVHFNYPSRSEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPL------EGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYG-REDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKL 624 HSP 3 Score: 123.635 bits (309), Expect = 1.525e-28 Identity = 104/370 (28.11%), Postives = 181/370 (48.92%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXX-------------XXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEE---FKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRT---LVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGX-XXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFWAALAA*PCQLCTTSIALCF 1051
VRNAD+I G I+EQGNH+ L+ +G+Y++++ Q + + + S ESK+ + R + ++E K + ++ F R++ ++ E YL+ GV+ A I G + P +++++ + VF+ D +K + L L+ G I + + KAGE LT R+R + S+L+Q++++FD+ +N G LT RLA +AS VK A G +L+V + + NL + + Y W+L+LL ++ IP I L GI++ KL +GQ L S + E + N RT+ SL+ + F Y SL++ + + + + + + S A CF
Sbjct: 591 VRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTRGNEIEPGNNAYGSQSDTDASELTSEESKSPLIRRSIYRSVHRKQDQERRLSMKEAVDEDVPLVS-FWRILNLNLSEWPYLLVGVLCAVINGCIQPVFAIVFSRIVGVFSRD----DDHETKRQNCNLFSLFFLVMGLISFVTYFFQGFTFGKAGEILTKRVRYMVFKSMLRQDISWFDDHKNSTGSLTTRLASDASSVKGAMGARLAVVTQNVANLGTGVILSLVYGWQLTLLLVVIIPLIVLGGIIEMKLLSGQALKDKKQLEISGKIATEAIENFRTIVSLTREQKFETMYAQSLQVPYRNAMKKAHVFGITFSFTQAMMYFSYAACF 955 HSP 4 Score: 52.373 bits (124), Expect = 2.176e-6 Identity = 31/106 (29.25%), Postives = 52/106 (49.06%), Query Frame = 2
Query: 506 WCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLST 823
WCL AG + ++R +++ QE+ +FD G L RL + S + G ++ +F ++I A IGF W+L+L+ L P I L+ + K+ T
Sbjct: 135 WCLA-AGRQIH-KIRQKFFHAIMNQEIGWFDVHD--VGELNTRLTDDVSKINDGIGDKIGMFFQSITTFLAGFIIGFISGWKLTLVILAVSPLIGLSSALWAKVLT 236
BLAST of Multidrug resistance protein 1 vs. Ensembl Mouse
Match: Abcb11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11 [Source:MGI Symbol;Acc:MGI:1351619]) HSP 1 Score: 306.99 bits (785), Expect = 4.677e-90 Identity = 153/303 (50.50%), Postives = 205/303 (67.66%), Query Frame = 1
Query: 1099 LMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE-EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+ RV S MS A+GR S KA+ +A + Q +DR ID + G + + G I+F + F YP+R ++ VL GL + ++ GQT+A VG SGCGKST IQLLER+YDP QG V++DGHD K +N+ ++R+ IG+V QEP LF+ S+ DNI YG N+ ++ E I AK A +HDF++SLPE Y T VG +G LS G+KQRI IARA+ P ILLLDEATSALDT+SE VQ ALD+A+E TC+VIAHRLSTI+N+D I ++ GVV+E GTH++L++ +G YY L
Sbjct: 1017 VFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDP------DQGTVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKLMDQKGAYYKL 1313 HSP 2 Score: 263.462 bits (672), Expect = 9.877e-75 Identity = 148/343 (43.15%), Postives = 221/343 (64.43%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGA-IFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKG-VVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K + +G +G +++ Y + F+ G+ + LD+G+ +L+++F C ++ +G A S + AA QTIDR +D G +++ G IEF N+ F YP+R V +L L + I G+T A VG SG GKST +QL++R+YDP +G V LDGHDI++LN+ W+R+QIG+V+QEP LF+ ++A+NI G + E +++ AK AN ++FI++LP+ ++T+VG+ GG +SGGQKQR+ IARAL KP ILLLD ATSALD +SE VQ AL++ Q T + +AHRLST+++AD I+ E+G VE GTHEEL+ +G Y+ L
Sbjct: 318 KGMVMGFFTGYMWCLIFFCYALAFWYGSRLVLDEGEYTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIFQTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGAGKSTALQLIQRFYDPC------EGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLG-REEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGVYFML 653 HSP 3 Score: 127.102 bits (318), Expect = 1.367e-29 Identity = 104/349 (29.80%), Postives = 181/349 (51.86%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFK--LEKPSKIQM----------IKDFI----------------------RLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHF 928
VR+AD+I+ ++G +E+G HE LL +G+Y+ ++ Q +E K+ + + K T D R S + ++ + + + SK Q+ I D R+++ + E Y++ G + A+I GAV P SL+++++ F+L + S+ ++ L +I G + LF Q + + K+GE LT RLR F ++L+Q++ +FD+ +N PGVLT RLA +AS V+ A G Q+ + + + N+ ++ I F +NW+LSL+ +F P +AL+G +Q K+ TG + L AG + E L+NIRTV + ++ F
Sbjct: 620 VRSADVIIGFEHGTAVERGTHEELLERKGVYFMLVTLQSQEDNTHKETGI--KGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKSQLSHLSHEPPLAIGDHKSSYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAINGAVTPIYSLLFSQILKTFSL--VDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAG-----QITNEALSNIRTVAGIGVEGRF 959
BLAST of Multidrug resistance protein 1 vs. UniProt/SwissProt
Match: sp|P21448|MDR1_CRIGR (ATP-dependent translocase ABCB1 OS=Cricetulus griseus OX=10029 GN=ABCB1 PE=1 SV=2) HSP 1 Score: 326.635 bits (836), Expect = 3.499e-122 Identity = 166/339 (48.97%), Postives = 226/339 (66.67%), Query Frame = 1
Query: 991 LGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHK-GVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMI-KVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G + +Y+ Y F GA + + +++ VFS A+G+ S A D KA+ +A + I+++ +ID++ G + L GN++F + F YPTR ++ VL+GL+L++ GQT+ALVG SGCGKST++QLLER+YDP G V LDG ++ LN+ W+R +G+V QEP LF+ S+A+NI YG NS V + I + AK ANIH FI SLP+ YNT VG +G LSGGQKQRI IARAL +P ILLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+I+NG V E GTH++L+ +G Y+ +
Sbjct: 935 FGITFSFTQAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIMIIEKVPSIDSYSTGGLKPNTLEGNVKFNEVVFNYPTRPDIPVLQGLNLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMA------GTVFLDGKEVNQLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIERAAKEANIHQFIESLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSM 1267 HSP 2 Score: 135.961 bits (341), Expect = 3.499e-122 Identity = 106/338 (31.36%), Postives = 176/338 (52.07%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTA-------------NEEEFKLEKPSKIQMIKD-----FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGX-XXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKL 958
VRNADII G I+EQGNHE L+ +G+Y++++ Q + E E+ + D +++ +S+ ++++ KL +K + +D F R+++++ E Y + G+ A + GA+ P S+I++++ VF + T + LL LI G I + + KAGE LT RLR + S+L+Q++++FD P+N G LT RLA +A VK A G +L+V + I NL + I Y W+L+LL L +P IA+ G+++ K+ +GQ L S + E + N RTV SL+ + F + Y SL++
Sbjct: 589 VRNADIIAGFDGGVIVEQGNHEELMREKGIYFKLVMTQTAGNEIELGNEVGESKNEIDNLDMSSKDSASSLIRRRSTRRSIRGPHDQDRKL--STKEALDEDVPPISFWRILKLNSSEWPYFVVGIFCAIVNGALQPAFSIIFSKVVGVFT-RNTDDETKRHDSNLFSLLFLILGVISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDNPKNTTGALTTRLANDAGQVKGATGARLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFENMYAQSLQI 923 HSP 3 Score: 303.523 bits (776), Expect = 4.837e-88 Identity = 158/334 (47.31%), Postives = 219/334 (65.57%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G A +Y Y + F+ G + + + ++ VF + ++G+A + AR AA + ID +ID+ G P+ + GN+EFKN+HF YP+R +V +L+GL+LK+ +GQTVALVG+SGCGKST +QLL+R YDP +G V +DG DI+ +N+ ++R IG+V QEP LF ++A+NI YG +V + + K K AN +DFI+ LP ++T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +VIAHRLST++NAD I + GV+VE G HEEL+ +G Y+ L
Sbjct: 297 GAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFAVLIGAFSIGQASPNIEAFANARGAAYEIFNIIDNKPSIDSFSKNGYKPD-NIKGNLEFKNIHFSYPSRKDVQILKGLNLKVQSGQTVALVGNSGCGKSTTVQLLQRLYDP------TEGVVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADIIAGFDGGVIVEQGNHEELMREKGIYFKL 622
BLAST of Multidrug resistance protein 1 vs. UniProt/SwissProt
Match: sp|P21440|MDR3_MOUSE (Phosphatidylcholine translocator ABCB4 OS=Mus musculus OX=10090 GN=Abcb4 PE=1 SV=2) HSP 1 Score: 336.265 bits (861), Expect = 1.313e-121 Identity = 174/343 (50.73%), Postives = 233/343 (67.93%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
G ++ + +Y+ Y F G+ + G ++ VFS + ALG A S A D KA+ +A +R ID++ +G+ P+ K G++ F + F YPTRANV VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP G VLLDG + K LN+ W+R Q+G+V QEP LF+ S+A+NI YG NS V ++ +++ AK ANIH FI +LP+ YNT VG +G LSGGQKQRI IARAL +P +LLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+IENG V E GTH++L+ +G Y+ + N+Q
Sbjct: 935 GITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSGEGLWPD-KFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMA------GSVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVPHDEIVRAAKEANIHPFIETLPQKYNTRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIENGKVKEHGTHQQLLAQKGIYFSMVNIQ 1270 HSP 2 Score: 124.405 bits (311), Expect = 1.313e-121 Identity = 95/337 (28.19%), Postives = 169/337 (50.15%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSST--ANEEEFKLEKPSKIQMIKD------------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
+RNAD+I ++G I+EQG+H L+ +G+Y+ ++ Q + ++ S D A + N + L+ P + ++ ++ F++++++++ E Y + G + A GA+ P S+I +E+ +F +LV L L G + F + + KAGE LTTRLR+ ++L+Q+M++FD+ +N G L+ RLA +A+ V+ A G +L++ + NL + I F Y W+L+LL L +P IA+ GI++ K+ G + + AG + E + NIRTV SL+ + F Y + L
Sbjct: 591 IRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRLVNMQTAGSQILSEEFEVELSDEKAAGDVAPNGWKARIFRNSTKKSLKSPHQNRLDEETNELDANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGALQPAFSIILSEMIAIFGPGDDAVKQQKCNMFSLVFLGL--GVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAG-----KIATEAIENIRTVVSLTQERKFESMYVEKL 920 HSP 3 Score: 300.442 bits (768), Expect = 6.160e-87 Identity = 164/353 (46.46%), Postives = 227/353 (64.31%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVS-GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
KKI K +S G+A +Y Y + F+ G+ + + + + M VF + ++G+A AR AA ID ID+ +G P+ + GN+EF ++HF YP+RAN+ +L+GL+LK+ +GQTVALVG+SGCGKST +QLL+R YDP +G++ +DG DI+ N+ +R IG+V QEP LF+ ++A+NI YG +V + + K K AN +DFI+ LP+ ++T+VG RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VQ ALD+A+E T +VIAHRLSTI+NAD I E+GV+VE G+H EL+ G Y+ L N+Q
Sbjct: 284 KKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPD-NIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDP------TEGKISIDGQDIRNFNVRCLREIIGVVSQEPVLFSTTIAENIRYG-RGNVTMDEIEKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTIRNADVIAGFEDGVIVEQGSHSELMKKEGIYFRLVNMQ 628
BLAST of Multidrug resistance protein 1 vs. UniProt/SwissProt
Match: sp|P21439|MDR3_HUMAN (Phosphatidylcholine translocator ABCB4 OS=Homo sapiens OX=9606 GN=ABCB4 PE=1 SV=2) HSP 1 Score: 327.791 bits (839), Expect = 8.741e-121 Identity = 172/340 (50.59%), Postives = 224/340 (65.88%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQ-GQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G ++ + +Y+ Y F GA + G ++ VFS ALG A S A D KA+ +A +R ID++ +G+ P+ K GNI F + F YPTRANV VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP + G LLDG + K LN+ W+R Q+G+V QEP LF+ S+A+NI YG NS V + ++ AK ANIH FI +LP Y T VG +G LSGGQKQRI IARAL +P ILLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+ +NG V E GTH++L+ +G Y+ +
Sbjct: 938 GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPD-KFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1276 HSP 2 Score: 129.798 bits (325), Expect = 8.741e-121 Identity = 100/340 (29.41%), Postives = 179/340 (52.65%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLT---PTDAATR--RLSSTANEEEFKLEKPSKIQMIKD----------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLV--LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
VRNAD+I ++G I+EQG+H L+ +G+Y++++ Q + + ++ + K T P +R R S+ N + ++ + S + + D F++++++++ E Y + G + A G + P S+I++E+ +F D + + + + L+ L G I F + + KAGE LT RLR+ ++L+Q+M++FD+ +N G L+ RLA +A+ V+ A G +L++ + I NL + I F Y W+L+LL L +P IA++GI++ KL G + L AG + E + NIRTV SL+ + F Y + L
Sbjct: 594 VRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKS-LDVETDGLEANVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPG----DDAVKQQKCNIFSLIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAG-----KIATEAIENIRTVVSLTQERKFESMYVEKL 923 HSP 3 Score: 299.671 bits (766), Expect = 9.824e-87 Identity = 157/338 (46.45%), Postives = 222/338 (65.68%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
G+A +Y Y + F+ G+ + + + + M VF + ++G+A AR AA ID ID+ +G P+ + GN+EF ++HF YP+RANV +L+GL+LK+ +GQTVALVG SGCGKST +QL++R YDP +G + +DG DI+ N++++R IG+V QEP LF+ ++A+NI YG +V + + K K AN ++FI+ LP+ ++T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VQ ALD+A+E T +VIAHRLST++NAD I E+GV+VE G+H EL+ G Y+ L N+Q
Sbjct: 302 GIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDS-IKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDP------DEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQ 631
BLAST of Multidrug resistance protein 1 vs. UniProt/SwissProt
Match: sp|Q08201|MDR3_RAT (Phosphatidylcholine translocator ABCB4 OS=Rattus norvegicus OX=10116 GN=Abcb4 PE=1 SV=1) HSP 1 Score: 330.487 bits (846), Expect = 1.579e-119 Identity = 172/343 (50.15%), Postives = 230/343 (67.06%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
G ++ + +Y+ Y F G+ + G ++ VFS + ALG A S A D KA+ +A +R ID++ +G+ P+ K G++ F + F YPTRANV VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP G VLLDG + K LN+ W+R Q+G+V QEP LF+ S+A NI YG NS V + +++ AK ANIH FI +LP+ Y T VG +G LSGGQKQRI IARAL +P +LLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+I+NG V E GTH++L+ +G Y+ + N+Q
Sbjct: 937 GITFSISQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQPLIDSYSREGMWPD-KFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMA------GTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQKGIYFSMVNIQ 1272 HSP 2 Score: 123.25 bits (308), Expect = 1.579e-119 Identity = 101/346 (29.19%), Postives = 169/346 (48.84%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXX------------XXXXXXXSPES-----------KTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
VRNAD+I ++G I+EQG+H L+ +G+Y+ ++ Q + E+ ++P K+L + A RL NE + + S F++++R+++ E Y + G + A GA+ P S+I +E+ +F +LV L L G F + + KAGE LTTRLR+ ++L+Q+M++FD+ +N G L+ RLA +A+ V+ A G +L++ + NL + I F Y W+L+LL L +P IA+ GI++ K+ G + + AG + E + NIRTV SL+ + F Y + L
Sbjct: 591 VRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLVNMQTSGSQILSEEFEVELSDEKAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDVETNELDANVPPVS-------FLKVLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGPGDDTVKQQKCNMFSLVFLGL--GVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKMLAGNAKRDKKEMEAAG-----KIATEAIENIRTVVSLTQERKFESMYVEKL 922 HSP 3 Score: 300.442 bits (768), Expect = 5.501e-87 Identity = 164/353 (46.46%), Postives = 226/353 (64.02%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVS-GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
KKI K +S G+A +Y Y + F+ G+ + + + + M VF + ++G+A AR AA ID ID+ +G P+ + GN+EF ++HF YP+RAN+ +L+GL+LK+ +GQTVALVG+SGCGKST +QLL+R YDP +G + +DG DI+ N+ +R IG+V QEP LF+ ++A+NI YG +V + + K K AN +DFI+ LP+ ++T+VG RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VQ ALD+A+E T +VIAHRLST++NAD I E+GV+VE G+H ELI G Y+ L N+Q
Sbjct: 284 KKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHKPDS-IKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDP------TEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYG-RGNVTMDEIKKAVKEANAYDFIMKLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLVNMQ 628
BLAST of Multidrug resistance protein 1 vs. UniProt/SwissProt
Match: sp|P23174|MDR3_CRIGR (Phosphatidylcholine translocator ABCB4 OS=Cricetulus griseus OX=10029 GN=ABCB4 PE=2 SV=1) HSP 1 Score: 328.561 bits (841), Expect = 8.056e-119 Identity = 170/343 (49.56%), Postives = 229/343 (66.76%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
G ++ + +Y+ Y F GA + G ++ VFS ALG A S A D KA+ +A +R ID++ +G+ P+ K G++ F + F YPTRAN+ VL+GL L++ GQT+ALVG SGCGKST++QLLER+YDP G VLLDG + K LN+ W+R Q+G+V QEP LF+ S+A+NI YG NS V + +++ AK ANIH FI +LP+ Y T VG +G LSGGQKQR+ I RAL +P +LLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NAD IV+I+NG V E GTH++L+ +G Y+ + N+Q
Sbjct: 940 GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFSLFERQPLIDSYSGEGLWPD-KFEGSVTFNEVVFNYPTRANMPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMA------GTVLLDGQEAKKLNIQWLRAQLGIVSQEPVLFDCSIAENIAYGDNSRVVSQDEIVRAAKAANIHPFIETLPQKYKTRVGDKGTQLSGGQKQRLAIRRALIRQPRVLLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVNIQ 1275 HSP 2 Score: 122.865 bits (307), Expect = 8.056e-119 Identity = 100/346 (28.90%), Postives = 177/346 (51.16%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXX------------XXXXXXXSPES-----------KTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVF-----ALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQ-RLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
VRNAD+I ++G I+EQG+H L+ +G+Y++++ Q + E+ ++P K+L + A RL A+E + + S F++++++++ E Y + G + A + GA+ P S+I +E+ +F A+K +L +LV L L G + F + + KAGE LTTRLR+ ++L+Q+M++FD+ +N G L+ RLA + + V+ A G +L++ + NL + I F Y W+L+LL L +P IA++GI++ K+ G + ++ + E + NIRTV SL+ + F Y + L
Sbjct: 594 VRNADVIAGFEDGVIVEQGSHSELMQKEGVYFKLVNMQTSGSQILSQEFEVELSEEKAADGMTPNGWKSHIFRNSTKKSLKSSRAHHHRLDVDADELDANVPPVS-------FLKVLKLNKTEWPYFVVGTVCAIVNGALQPAISIILSEMIAIFGPGDDAVKQQKCNLF-----SLVFLGL--GVLSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDYKNSTGALSTRLATDRAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVSGIVEMKMLAGNAKRDKKALEAAGKIATEAIENIRTVVSLTQERKFESMYVEKL 925 HSP 3 Score: 298.901 bits (764), Expect = 1.850e-86 Identity = 161/353 (45.61%), Postives = 228/353 (64.59%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVS-GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQ 2010
KKI K +S G+A +Y Y + F+ G+ + + + + M VF + ++G+A AR AA ID ID+ +G P+ + GN++F ++HF YP+RAN+ +L+GL+LK+ +GQTVALVG+SGCGK+T +QLL+R YDP +G + +DG DI+ N+ ++R IG+V QEP LF+ ++A+NI YG +V E + K K AN ++FI+ LP+ ++T+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VQ ALD+A+E T +VIAHRLST++NAD I E+GV+VE G+H EL+ G Y+ L N+Q
Sbjct: 287 KKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDS-IKGNLDFSDVHFSYPSRANIKILKGLNLKVQSGQTVALVGNSGCGKTTTLQLLQRLYDP------TEGTISIDGQDIRNFNVRYLREIIGVVSQEPVLFSTTIAENIRYG-RGNVTMEEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMQKEGVYFKLVNMQ 631
BLAST of Multidrug resistance protein 1 vs. TrEMBL
Match: U3JZD0 (ATP binding cassette subfamily B member 4 OS=Ficedula albicollis OX=59894 GN=ABCB4 PE=4 SV=1) HSP 1 Score: 347.821 bits (891), Expect = 5.821e-127 Identity = 180/352 (51.14%), Postives = 238/352 (67.61%), Query Frame = 1
Query: 970 IKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQN 2013
+K +F C + L+ + +++ Y F GA + G + + VFS ALG+ S A D KA+ +A +R+ +ID++ +G PE GNI K++ F YP R V +L+GL+LK+ GQT+ALVG SGCGKST++QLLER+YDP +G++L DG + KALN+ W+R QIG+V QEP LF+ ++A+NI YG NS V +E ++ AK ANIH FI SLP YNT VG +G LSGGQKQRI IARAL KP ILLLDEATSALDT+SE +VQEALD+A+E TC+VIAHRLSTI+NADKI +++NG VVE GTH++L+ +G YY L NVQN
Sbjct: 941 VKKAHIFGFCFA-LSQAMMFFTYAGCFRFGAYLVVNGHMEYKDVFLVFSAVVFGAMALGQTSSFAPDYAKAKISAAHLFLLFERVPSIDSYSEEGDKPE-TFDGNITIKDVVFNYPNRPEVKILQGLNLKVEKGQTLALVGSSGCGKSTVVQLLERFYDPL------EGEMLFDGKNAKALNIQWLRAQIGIVSQEPILFDFTIAENIAYGDNSRQVPFEEIVSAAKEANIHSFIDSLPNKYNTRVGDKGTQLSGGQKQRITIARALVRKPQILLLDEATSALDTESEKIVQEALDKAREGRTCIVIAHRLSTIQNADKIAVVQNGTVVEQGTHQQLLAEKGIYYSLVNVQN 1284 HSP 2 Score: 138.658 bits (348), Expect = 5.821e-127 Identity = 111/352 (31.53%), Postives = 179/352 (50.85%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFK---------------LEKPSKIQMIKD--------------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
VRNAD+I V + G I EQGNH LL +G+Y++++ Q E + P S+ R + ++ +E EFK ++KP D F+++M++++ E Y +AG++ A I GA+ P ++I++E+ +F+ T D++ + LL L+ G I F + + KAGE LT RLR ++L+Q+M +FD P+N G LT RLA +AS VK A G++L++ + I NL + I Y W+L+LL L +P IA+ G+++ K+ G Q L +AG + + + NIRTV SL+ + F Y + L
Sbjct: 600 VRNADLIAVFEGGVIKEQGNHAQLLERKGIYYKLVSMQAIEAEV-------PSSENYENV----RSVKNSESEPEFKEPLTRGLRRRSTRRSMKKPGGQSDSPDEEKASPAEELPPASFMKIMKLNKTEWPYFVAGLLCAIINGALQPAFAIIFSEIIGIFSE--TDKDILRKQSNLYSLLFLVLGIISFFTFFFQGFTFGKAGEILTMRLRFMAFKAMLRQDMGWFDNPKNSTGALTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAVVPIIAVAGMIEMKMLAGHAKKDKQELESAG-----KIATQAIENIRTVASLTRERKFESMYGEYL 933 HSP 3 Score: 305.449 bits (781), Expect = 3.044e-86 Identity = 159/334 (47.60%), Postives = 213/334 (63.77%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHK--GVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G A +Y Y + F+ G + + ++ VF + ++G+ + AR AA ID ID++ G P+ + GN+EF N++F YP+R +V +L+GL+LKIN+GQTVALVG SGCGKST +QL++R+YDP +G V +DG DIK LN+ ++R IG+V QEP LF ++A+NI YG DV E + K K AN +DFI+ LP + TVVG RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +V+AHRLST++NAD I + E GV+ E G H +L+ +G YY L
Sbjct: 308 GAAFLLIYASYALAFWYGTTLILNDDYTIGKVLTVFFSVLIGAFSIGQTAPSIEAFASARGAAYTVFNIIDTEPQIDSYSEAGYKPDH-IKGNLEFTNVYFNYPSRPDVEILKGLNLKINSGQTVALVGGSGCGKSTTVQLIQRFYDP------KEGTVTIDGQDIKTLNVRYLREVIGVVNQEPVLFATTIAENIRYG-REDVTMEEIEKATKEANAYDFIMKLPNKFETVVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKAREGRTTVVVAHRLSTVRNADLIAVFEGGVIKEQGNHAQLLERKGIYYKL 633
BLAST of Multidrug resistance protein 1 vs. TrEMBL
Match: A0A4E0RLC9 (Multidrug resistance protein 1 OS=Fasciola hepatica OX=6192 GN=D915_007290 PE=4 SV=1) HSP 1 Score: 344.739 bits (883), Expect = 1.371e-126 Identity = 167/342 (48.83%), Postives = 243/342 (71.05%), Query Frame = 1
Query: 985 VFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQ-VLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLN 2004
+ + L + + + F +GA ++ +M+++ RVF+ MS +LGR S+ +T++AR+A++ L+T+DR +I G+VP E GN+EFK+++F YPTR +SVL+ +N+G+TVALVG SGCGKSTL+QL++R+YDP ++G + DGH+I+ L +WVR QIG+V QEP+LF++S+ DNI YG NS +V + +++ A+ AN+H+FI +LPEGY+T VGQ+G HLSGGQKQR+ IARAL KP +LLLDEATSALD +SE VVQEALD A + TCL++AHRLST++NAD IV++ENG +E+G E L+N +G +Y L+
Sbjct: 906 ILFAVLFSLTQAGPMFCFAAAFTLGAFLVEHKYIEMLAVFRVFAVLNMSAQSLGRTASIGPETQRAREASKIILKTLDRTPSIRTDDGLVPREPFRGNVEFKHVYFSYPTRKTISVLKKFSHAVNSGETVALVGESGCGKSTLLQLVQRFYDP---DDFGSDSGIFFDGHNIRQLAPAWVRRQIGIVSQEPNLFDMSIRDNIAYGDNSREVTMDEIMEAARQANVHEFITTLPEGYDTSVGQKGSHLSGGQKQRVAIARALLRKPILLLLDEATSALDVESERVVQEALDSAMGSRTCLMVAHRLSTVENADLIVVLENGRKIEAGAPEALLNAKGAFYTLH 1244 HSP 2 Score: 140.584 bits (353), Expect = 1.371e-126 Identity = 113/348 (32.47%), Postives = 185/348 (53.16%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXX-------SPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIKD----------------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSN 976
VRNAD+I+V+ G I E+G H+ L+ GLY ML Q + K + + S ++ ++ A L+ N EF P I+ + + R+++++R E GY+I G +A+ I GAV P +L+Y++++ +F P+ M S+ L + G + G L + + +GE LT R+R + ++++QE+ +FD +N PG LTA LA EAS +KS +G QL IEA ++ SL I F Y+W+L+LL L F P L+G++Q K G+ S S+ L E +++ RTV +L+L+D+F ++ F+ L ++ K SN
Sbjct: 557 VRNADLIMVLDKGVIREKGTHDELVERNGLYAAMLHIQKQTDKNQLGEAEPVDDIGLSKKTNLRNGSNGAMWTLADDDNSVEFSHASPQLIRRVSEASINLGKKIFTFKRSPIFRILKMNRTELGYIIGGCVASLIAGAVQPSFALLYSQMFQIFTYA-NDPEKMRSQVSIFAALMVFLGCLRFLGMLGQGFFFGVSGERLTRRVRGMLFQAIMRQEIGWFDRTENQPGTLTAVLATEASKMKSLSGSQLGFIIEAFALVTMSLVIAFIYSWQLTLLMLAFYPMFILSGMLQIKRIAGEG-SKETDGPSTQLAQEAISSDRTVFTLNLEDYFQNR-FEDLLMNKKLSN 901 HSP 3 Score: 280.796 bits (717), Expect = 1.198e-77 Identity = 154/334 (46.11%), Postives = 212/334 (63.47%), Query Frame = 1
Query: 991 LGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHY 1992
LG V G L+ ++F+ G + +++ VF + + LG AL Q A +A + IDR+ ID + TGNI FK++ F YPTR ++ VL+ +L++ +GQTVALVG SG GKST++ +L+R+YDP G+++++G +I+ L+L R Q+G V+QEP LF +V DNI G D E +I+ AKMAN HDFIL LPEGY TV+ +RG LSGGQKQRI IARAL KP +LLLDEATSALDT+SE VVQEALD+A T +V+AHRL+T++NAD I++++ GV+ E GTH+EL+ G Y
Sbjct: 261 LGGVVGAIGLTLFSSAALIFWYGIELIITENYSGGTVVTVFINVVIGSIFLGNALPNMQYFLIAMASATEVYGLIDRVPPIDKDRSGKRIPDFTGNIIFKDVDFAYPTRPDIVVLKKFNLELKSGQTVALVGPSGSGKSTIVHMLQRFYDPI------GGEIIVEGENIRDLDLKAFRAQLGCVQQEPILFEGTVEDNIRLG-KLDATNEEIIEAAKMANAHDFILHLPEGYKTVLAERGAGLSGGQKQRIAIARALIRKPKLLLLDEATSALDTRSERVVQEALDQASAGRTVVVVAHRLTTVRNADLIMVLDKGVIREKGTHDELVERNGLY 587
BLAST of Multidrug resistance protein 1 vs. TrEMBL
Match: G1N7X9 (Uncharacterized protein OS=Meleagris gallopavo OX=9103 PE=4 SV=2) HSP 1 Score: 341.273 bits (874), Expect = 2.781e-126 Identity = 179/352 (50.85%), Postives = 233/352 (66.19%), Query Frame = 1
Query: 970 IKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQN 2013
+K +F C S L+ + +++ Y F GA + G + S+ VFS ALG+ S A D KA+ +A DR+ +ID++ G P GN K++ F YP R V +L+GL+LK+ GQT+ALVG SGCGKST++QLLER+YDP G++ D D K LN+ W+R+ IG+V QEP LF+ ++A+NI YG N+ +V +E +I AK ANIH FI SLPE YNT VG +G LSGGQKQRI IARAL KP ILLLDEATSALDT+SE VVQEALD+A+E TC+VIAHRLSTI+NADKI +I+NG V E GTH++L+ +G YY L NVQ+
Sbjct: 820 VKKAHIFGFCFS-LSQAMMFFTYAGCFRFGAYLVVNGHMEYKSVFLVFSAVVFGAMALGQTSSFAPDYAKAKISAAHLFVLFDRVPSIDSYCEDGEKPV-TFGGNTRIKDVKFNYPNRPEVKILQGLNLKVEKGQTLALVGSSGCGKSTVVQLLERFYDPL------SGEIEFDDKDAKTLNIQWLRSHIGIVSQEPILFDFTIAENIAYGDNTREVSHEEIISAAKAANIHSFIDSLPEKYNTRVGDKGAQLSGGQKQRIAIARALVRKPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADKIAVIQNGKVTEQGTHQQLLAEKGFYYSLVNVQS 1163 HSP 2 Score: 142.51 bits (358), Expect = 2.781e-126 Identity = 112/354 (31.64%), Postives = 179/354 (50.56%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFK--LEKPSKIQMIK----------------------DFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQ------RLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKS 973
VRNAD+I V NG I EQGNH L+ +G+Y++++ Q E + P S+ + R S + +E K L + S + +K F+++M+++R E Y +AG + A I GA+ P ++I++E+ +F+ + ++ K LL L+ G I F + + KAGE LT RLR ++L+Q+MA+FD+P+N G LT RLA +AS VK A G++L++ + I NL + I Y W+L+LL L +P IA+ G+++ K+ G L AG + E + NIRTV SL+ + F Y + L + + S
Sbjct: 480 VRNADLIAVFDNGVITEQGNHSQLIEKKGIYYKLVNMQAIETE-------DPSSEKDENAVSVKRSGSQSNLDESLKRGLRRGSTRRSMKRPGEPNDTDGKGSSSAEELPPVSFLKVMKLNRKEWPYFVAGTLCAVINGALQPAFAVIFSEIIGIFSEED--EKVLREKSNLYSLLFLVLGIISFFTFFVQGFAFGKAGEILTMRLRFMAFKAMLRQDMAWFDDPKNSTGALTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAVVPIIAVAGMIEMKMLAGHAKKDKIELEAAG-----KIATEAVENIRTVASLTREKRFELMYGEHLHVPYRNS 819 HSP 3 Score: 306.22 bits (783), Expect = 5.974e-87 Identity = 159/340 (46.76%), Postives = 221/340 (65.00%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHK--GVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQNV 2016
G A +Y Y + F+ G + + +++ VF + ++G+ + AR AA ID ID++ G P+ + GN+EF+N+ F YP+R +V +L+GL+LKIN GQTVALVG SGCGKST +QL++R+YDP +G + +DG D+K+LN+ ++R IG+V QEP LF ++A+NI YG DV E + K K AN +DFI+ LP+ + TVVG+RG +SGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +V+AHRLST++NAD I + +NGV+ E G H +LI +G YY L N+Q +
Sbjct: 188 GAAFLLIYASYALAFWYGTTLILNDDYTIGNVLTVFFSVLIGAFSIGQTTPSIEAFANARGAAYAIFNIIDNEPQIDSYSDAGHKPDH-IKGNLEFQNVFFNYPSRPDVEILKGLNLKINCGQTVALVGGSGCGKSTTVQLIQRFYDP------KEGTITIDGQDLKSLNVRYLREIIGVVNQEPVLFATTIAENIRYG-REDVTMEEIEKATKEANAYDFIMKLPKKFETVVGERGAQMSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKAREGRTTVVVAHRLSTVRNADLIAVFDNGVITEQGNHSQLIEKKGIYYKLVNMQAI 519
BLAST of Multidrug resistance protein 1 vs. TrEMBL
Match: W6SB20 (Multidrug resistance protein 1 (Fragment) OS=Corvus corone OX=30422 GN=ABCB1 PE=2 SV=1) HSP 1 Score: 345.125 bits (884), Expect = 5.505e-126 Identity = 179/352 (50.85%), Postives = 238/352 (67.61%), Query Frame = 1
Query: 970 IKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQN 2013
+K +F C + L+ + +++ Y F GA + + S+ VFS ALG+ S A D KA+ +A + +R+ +ID++ +G PE GNI K++ F YP R V +L+GL+LK+ GQT+ALVG SGCGKST++QLLER+YDP G++L DG + KALN+ W+R QIG+V QEP LF+ ++A+NI YG NS V +E ++ AK ANIH FI SLP YNT VG +G LSGGQKQRI IARAL KP ILLLDEATSALDT+SE +VQEALD+A+E TC+VIAHRLSTI+NADKI +++NG VVE GTH++L+ +G YY L NVQ+
Sbjct: 580 VKKAHIFGFCFA-LSQAMMFFTYAGCFRFGAYLVVNDHMESTSVFLVFSAVVFGAMALGQTSSFAPDYAKAKISAAHLFRLFERVPSIDSYSEEGDKPE-TFEGNITIKDVAFNYPNRPEVKILQGLNLKVEKGQTLALVGSSGCGKSTVVQLLERFYDPL------DGEMLFDGKNAKALNIQWLRAQIGIVSQEPILFDFTIAENIAYGDNSRQVSFEEIVSAAKEANIHSFIDSLPNKYNTRVGDKGTQLSGGQKQRIAIARALVRKPHILLLDEATSALDTESEKIVQEALDKAREGRTCIVIAHRLSTIQNADKIAVVQNGKVVEQGTHQQLLAEKGIYYSLVNVQS 923 HSP 2 Score: 137.887 bits (346), Expect = 5.505e-126 Identity = 113/341 (33.14%), Postives = 175/341 (51.32%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXX-----------XXXXXXXXXXXSPE---SKTLTPTDAATRRLSSTANEEEF--KLEKPSKIQMIK--DFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
VRNAD+I V ++G I EQGNH LL +G+Y +++ Q + K+ PE S T +TRR E+ EK S + ++ F+++M++++ E Y +AG + A I G + P +I++E+ +F+ T D++ K LL L+ G I F + + KAGE LT RLR ++L+Q+M +FD P+N G LT RLA +AS VK A G++L++ + I NL + I Y W+L+LL L +P IA+ G+++ K+ G Q L AG + E + NIRTV SL+ + F Y + L
Sbjct: 239 VRNADLIAVFESGVITEQGNHAKLLERKGIYHKLVNMQAIEAEVPPSEDDENAHSAKNSGSEPEFEESLTTGLRRRSTRRSMKKPGEQNNGPDEEKTSPDEELRPASFLKIMKLNKNEWPYFVAGTLCAIINGGLQPAFXVIFSEIIGIFSE--TDKDILREKSNLYSLLFLVIGIISFFTFFFQGFTFGKAGEILTMRLRFMAFKAMLRQDMGWFDNPKNSTGALTTRLANDASQVKGATGVRLALIAQNIANLGTGIIISLVYGWQLTLLLLAVVPIIAVAGMIEMKMLAGHAKKDKQELEAAG-----KIATEAIENIRTVVSLTRERKFESMYGEHL 572 HSP 3 Score: 298.13 bits (762), Expect = 1.728e-85 Identity = 150/282 (53.19%), Postives = 199/282 (70.57%), Query Frame = 1
Query: 1180 ARKAARKTLQTIDRLTAIDAHK--GVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQNV 2016
AR AA ID ID++ G P+ + GN+EF+N+HF YP+R +V +L+GL+LK+N GQTVALVG SGCGKST +QL++R+YDP +G + +DG DIK LN+ ++R IG+V QEP LF ++A+NI YG DV E + K K AN +DFI+ LP+ + TVVG+RG LSGGQKQRI IARAL P ILLLDEATSALDT+SE VVQ ALD+A+E T +V+AHRLST++NAD I + E+GV+ E G H +L+ +G Y+ L N+Q +
Sbjct: 5 ARGAAYAVFNIIDNEPQIDSYSETGYKPDH-IKGNLEFQNVHFSYPSRPDVQILKGLNLKVNCGQTVALVGGSGCGKSTTVQLIQRFYDP------KEGTITIDGQDIKTLNVRYLREIIGVVNQEPVLFATTIAENIRYG-REDVTMEEIEKATKEANAYDFIMKLPKKFETVVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESESVVQAALDKAREGRTTIVVAHRLSTVRNADLIAVFESGVITEQGNHAKLLERKGIYHKLVNMQAI 278
BLAST of Multidrug resistance protein 1 vs. TrEMBL
Match: A0A504YDC3 (Multidrug resistance protein 1 OS=Fasciola gigantica OX=46835 GN=FGIG_06363 PE=4 SV=1) HSP 1 Score: 340.502 bits (872), Expect = 6.658e-126 Identity = 166/342 (48.54%), Postives = 242/342 (70.76%), Query Frame = 1
Query: 985 VFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQ-VLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLN 2004
+ + L + + + F +GA ++ +M+++ RVF+ MS +LGR S+ +T++AR+A++ L+T+DR +I G+VP E GN+EFK+++F YPTR +SVL+ +N+G+TVALVG SGCGKSTL+QL++R+YDP ++G + DGH+I+ L +WVR QIG+V QEP+LF++S+ DNI YG NS +V + +++ A+ ANIH+FI +LPEGY+T VGQ+G LSGGQKQR+ IARAL KP +LLLDEATSALD +SE VVQ+ALD A + TCL++AHRLST++NAD IV++ENG +E+G E L+N +G +Y L+
Sbjct: 906 ILFAVLFSLTQAGPMFCFAAAFTLGAFLVEHKYIEMLAVFRVFAVLNMSAQSLGRTASIGPETQRAREASKIILETMDRTPSIRTDDGLVPREPFRGNVEFKHVYFNYPTRKTISVLKKFSHAVNSGETVALVGESGCGKSTLLQLVQRFYDP---DDFGSDSGIFFDGHNIRQLAPAWVRRQIGVVSQEPNLFDMSIRDNIAYGDNSREVTMDEIMEAARQANIHEFITTLPEGYDTSVGQKGSRLSGGQKQRVAIARALLRKPILLLLDEATSALDVESEQVVQKALDSAMGSRTCLMVAHRLSTVENADLIVVLENGRKIEAGAPEALLNAKGAFYTLH 1244 HSP 2 Score: 142.124 bits (357), Expect = 6.658e-126 Identity = 113/348 (32.47%), Postives = 186/348 (53.45%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTP-------TDAATRRLSSTANEEEFKLEKPSKIQMIKD----------------FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSN 976
VRNAD+I+V+ G I E+G H+ L+ GLY ML Q + K + + + L+ ++ A L+ N EF P I+ + + R+++++R E GY+I G +A+ I GAV P +L+Y++++ +F P+ M S+ +L + G + G L + + +GE LT R+R + ++++QE+ +FD +N PG LTA LA EAS +KS +G QL IEA ++ SL I F Y+W+L+LL L F P L+G++Q K G+ S S+ L E +++ RTV +L+L+D+F ++ F+ L ++ K SN
Sbjct: 557 VRNADLIMVLDKGVIREKGTHDELVEQNGLYAAMLHIQKQTDKNQLGEAGPVDDAGLSKKTNLRNGSNGAMWTLADDDNSVEFSHTSPQLIRRMSEASINFGKKIFTFKRSPIFRILKMNRTELGYIIGGCVASLIAGAVQPSFALLYSQMFQIFTYA-NDPEKMRSQVSIFAVLMVFLGCLRFLGMLGQGFFFGVSGERLTRRVRGMLFQAIMRQEIGWFDRTENQPGTLTAVLATEASKMKSLSGSQLGFIIEAFALVTMSLVIAFIYSWQLTLLMLAFYPMFILSGMLQIKRIAGEE-SKETDGPSTQLAQEAISSDRTVFTLNLEDYFQNR-FEDLLMNKKLSN 901 HSP 3 Score: 282.337 bits (721), Expect = 3.242e-78 Identity = 155/334 (46.41%), Postives = 213/334 (63.77%), Query Frame = 1
Query: 991 LGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHY 1992
LG V G L+ ++F+ G + +++ VF + + LG AL Q A +A + IDR+ ID + TGNI FK++ F YPTR+++ VL+ +L++ +GQTVALVG SG GKST+I +L+R+YDP G+++++G +I+ L+L R Q+G V+QEP LF +V DNI G D E +I+ AKMAN HDFIL LPEGY TV+ +RG LSGGQKQRI IARAL KP +LLLDEATSALDT+SE VVQEALD+A T +V+AHRL+T++NAD I++++ GV+ E GTH+EL+ G Y
Sbjct: 261 LGGVVGAIGLTLFSSAALIFWYGIELIITENYSGGTVVTVFINVIIGSIFLGNALPNMQYFLIAMASATEVYSLIDRVPPIDKDQSGKGIPDFTGNIIFKDVDFAYPTRSDIVVLKKFNLELKSGQTVALVGPSGSGKSTIIHMLQRFYDPI------GGEIIVEGENIRDLDLKAFRAQLGCVQQEPVLFEGTVEDNIRLG-KLDATNEEIIEAAKMANAHDFILHLPEGYKTVLAERGAGLSGGQKQRIAIARALIRKPKLLLLDEATSALDTRSERVVQEALDQASTGRTVVVVAHRLTTVRNADLIMVLDKGVIREKGTHDELVEQNGLY 587
BLAST of Multidrug resistance protein 1 vs. Ensembl Cavefish
Match: abcb4 (multidrug resistance protein 1 [Source:NCBI gene;Acc:103043081]) HSP 1 Score: 336.265 bits (861), Expect = 1.048e-119 Identity = 172/350 (49.14%), Postives = 230/350 (65.71%), Query Frame = 1
Query: 961 WKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
++ K K G + + +Y+ Y F GA +++ D + V S A+G A S + KA+ +A L I+R+ AID + +G PE+ GN+ F ++HF+YP+R +V VL+GL L++ GQ++ALVG SGCGKST IQLLER+YDP QG V+LD D K LN+ W+R+QIG+V QEP LF+ S+A+NI YG NS V E + + AK ANIH FI LP+ Y T G +G LSGGQKQRI IARA+ P +LLLDEATSALDT+SE +VQEALD+A+E TC+V+AHRLSTI+NAD I + +NGVVVE GTH++L+N +G YY L
Sbjct: 688 YQNAKKKAHIFGLTFSFSQAMIYFAYAGCFRFGAWLIEQKMMDFEGVYLVISAVMYGAMAVGEANSFTPNYAKAKISASHVLMLINRVPAIDNESEEGEKPED-FEGNVRFHDVHFKYPSRPDVPVLQGLRLRVKKGQSLALVGSSGCGKSTTIQLLERFYDPM------QGAVMLDDKDAKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRQVTQEEIERAAKAANIHSFIQELPQKYLTQAGDKGTQLSGGQKQRIAIARAILRNPKLLLLDEATSALDTESEKIVQEALDKAREGRTCIVVAHRLSTIQNADVIAVFQNGVVVEQGTHQQLLNQQGVYYTL 1030 HSP 2 Score: 115.161 bits (287), Expect = 1.048e-119 Identity = 91/327 (27.83%), Postives = 169/327 (51.68%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLY--------WXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSS--TANEEEFKLEKPSKIQMIKD--FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHF 928
+RNAD+I +NGKI+E G H+ L+ +G+Y + E ++ E SP ++T ++ S + +E+ + ++P + + + D F ++ +++ E Y++ GV A I G + P ++I++++ +VFA D++ + L+ + G + + + K+GE LT RLR ++L+Q+ ++D+P+N G LT RLA + + V+ A G++++ + + NL S+ I F Y W+L+LL L +P +A+ G +Q K+ G + L AG + E + NIRTV SL+ + F
Sbjct: 357 IRNADVIAGFQNGKIVELGTHDELMGMKGVYQSLVTMQTFNKSEDADDSAEDIGLNEKSPSVSSMTEQTLFRQKSKSFIGSEKEQKEEKEPVQEEKVPDVSFFTVLGLNKTEWPYMVLGVFCAIINGGMQPAFAIIFSKIISVFA--NLDEDIVRERTNFFSLMFAVIGAVSFVALFLQGYSFGKSGEILTMRLRYRAFRAMLRQDPGWYDDPKNSVGALTTRLATDTAQVQGATGVRMATLAQNVANLGTSIIISFVYGWQLTLLILSIVPIMAVAGAIQMKMLGGHAVKDKKELELAG-----KVATEAIENIRTVVSLTRESKF 676 HSP 3 Score: 302.368 bits (773), Expect = 9.615e-90 Identity = 156/343 (45.48%), Postives = 219/343 (63.85%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K + + G +Y Y + F+ G+ + + + +L+ VF + +G+ Q AR AA K ID +ID+ +G P+ + GNIEF+N+HF YP+R +V VL G++LKI +GQT+ALVG SGCGKST +QLL+R+YDP +G V +D HDI+++N+ +R IG+V QEP LF S+A+NI YG DV E + + + AN +DFI+ LP+ + T+VG RG +SGGQKQRI IARAL P ILLLDEATSALDT+SE +VQ ALD+ + T +++AHRLSTI+NAD I +NG +VE GTH+EL+ ++G Y L
Sbjct: 56 KAIMVNISVGFVYFMIYMSYALAFWYGSTLIIAKEYQVGNLLTVFFAVIIGAFGIGQTSPNIQAFASARGAAHKVFSIIDHKPSIDSFSEEGYKPD-VVKGNIEFRNIHFNYPSRQDVKVLNGMNLKIRSGQTIALVGSSGCGKSTTVQLLQRFYDPQ------EGTVTIDDHDIRSMNVRCLRELIGVVSQEPVLFATSIAENIRYG-REDVTQEEIEQATREANAYDFIMKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAIVQAALDKVRLGRTTIIVAHRLSTIRNADVIAGFQNGKIVELGTHDELMGMKGVYQSL 390
BLAST of Multidrug resistance protein 1 vs. Ensembl Cavefish
Match: abcb5 (ATP-binding cassette, sub-family B (MDR/TAP), member 5 [Source:ZFIN;Acc:ZDB-GENE-030131-6414]) HSP 1 Score: 323.939 bits (829), Expect = 1.427e-117 Identity = 173/350 (49.43%), Postives = 226/350 (64.57%), Query Frame = 1
Query: 961 WKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+K K G LA + Y V VF GA + T ++ VFS + ++G++ S A D KA+ AA + L +++ ID + G P G+IEF LHF YPTR N+ +L+GL++ + GQT+ALVG SGCGKST IQLLER+Y+P GQV DG D + LNL+W+R+Q+GLV QEP LF+ ++ +NI YG NS V E + + AK ANIH+FIL+LPE YNT VG +G LSGGQKQRI IARAL P +LLLDEATSALDT+SE +VQ+ALD A++ TC+VIAHRL+T++NAD I +I+NG VVE G H EL+ G YY L
Sbjct: 812 YKSALCKAPIYGITFALAQAIPYLVNAAVFRFGAWLIAHCHTQYENVFLVFSVIIFAAMSIGQSSSFAPDFAKAKVAAGRILSLLEKTPEIDIYSEAGDKPM-NFKGDIEFHELHFSYPTRPNIKILQGLNVSVRQGQTLALVGGSGCGKSTSIQLLERFYNP------AGGQVFADGMDTRMLNLAWLRSQLGLVSQEPILFDCTITENIQYGDNSRVVSQEEVEEAAKNANIHEFILNLPERYNTRVGDKGTQLSGGQKQRIAIARALVRNPKVLLLDEATSALDTESEKIVQKALDDARQGRTCIVIAHRLTTVQNADIIAVIQNGQVVEQGMHSELMAKHGAYYAL 1154 HSP 2 Score: 120.553 bits (301), Expect = 1.427e-117 Identity = 101/325 (31.08%), Postives = 177/325 (54.46%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTG-------IMQGKLSTGQR-LSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
+R AD+I K G+++EQG H LLN +G+Y+ ++ Q+K K+ S + K+ ++ + S + +++ + + P F R++ +++ E Y++ G +A+ + GAV+PC +++A++ VFA T P++ K LL L+ G + + + K+GE LT RLR+ ++L+Q++++FD+ N GVLT +LA +ASLVK G ++ + ++ L S+ I F ++W+L+LL L +P LTG MQG S Q L T+G + E + N +TV +L+ +D F K+ DSL
Sbjct: 499 IRTADVIAGFKEGEVVEQGTHRELLNKKGVYYSLVMQQVKIKQLSNYTT-SIQGKSGKKKNSKKDKKSKSKKDKKNEEKVPEI-----PFGRILALNKPEWPYVMVGTLASLVGGAVYPCVGILFAKIIGVFAE--TDPEVKRQKTMMFSLLFLLVGAVAFITYFFQGYMFGKSGEILTMRLRSQAFKAILRQDISWFDDHNNAVGVLTTKLATDASLVKGVTGSRIGLATSSVCALGISVIIAFCFSWQLTLLILACVPF--LTGANFIQMRAMQGHASKDQSALETSG-----KISTETVENFKTVVALTKEDVFFRKFNDSL 808 HSP 3 Score: 285.804 bits (730), Expect = 5.736e-86 Identity = 158/341 (46.33%), Postives = 215/341 (63.05%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGA-IFLDKGKTDMIS-LMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNV 2016
G+ ++ Y + F+ G + +D+ + I ++ VF + +LG+ + KAR AA TID ID+ +G P+ + G+IEFKN+HF YP+R +V +L+G+ LK+ G+T+ALVG SGCGKST IQLL+R+YDP G+V LDG DI++LN+ W+R +G+V QEP LF ++A+NI YG D + + + + AN ++FI LP+G NT+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDTQSE Q A+ T +VIAHRLSTI+ AD I + G VVE GTH EL+N +G YY L +Q V
Sbjct: 207 GITQFFIFGTYALAFWYGTKLSVDEPENYSIGKVITVFFSVMIGAFSLGQGAPNLESVAKARGAAYSIYNTIDMPRPIDSSSKEGHKPDS-VRGDIEFKNIHFSYPSRKDVKILQGMSLKVPHGKTIALVGASGCGKSTTIQLLQRFYDP------DAGEVTLDGRDIRSLNVRWLRENMGIVSQEPVLFGTTIAENIRYGREDATD-QDIDRAVREANAYEFISKLPDGLNTMVGERGAQLSGGQKQRIAIARALVKNPKILLLDEATSALDTQSE--SQGNFPNARAGRTTIVIAHRLSTIRTADVIAGFKEGEVVEQGTHRELLNKKGVYYSLVMQQV 537 HSP 4 Score: 53.1434 bits (126), Expect = 5.736e-86 Identity = 50/187 (26.74%), Postives = 86/187 (45.99%), Query Frame = 2
Query: 404 KFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKL---STGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
+ TF L ++ R I +LL G L+ A T R+R +VL Q+MA+FD + G L RL + + + G ++ +F++ A + IGF Y W+L+L+ + P +A + + K+ TG+ LS + + + V IRTV + + Q +KY +L+
Sbjct: 8 RLTFSFLPLNSQRNSYYFVGIGAGVLLLGTFQVMLFLLTATRQ-TKRIREKYFHAVLHQQMAWFDT--HPIGELNTRLTDDINTINDGLGDKICIFVQFFCRFLAGIIIGFIYGWKLTLVIMSVSPLLAGSAAVWSKILATLTGKELSAYAKAGAVAEEILVA--IRTVVAFNGQQKALEKYEKNLE 189
BLAST of Multidrug resistance protein 1 vs. Ensembl Cavefish
Match: abcb4 (multidrug resistance protein 1 [Source:NCBI gene;Acc:103043081]) HSP 1 Score: 335.495 bits (859), Expect = 1.879e-116 Identity = 172/350 (49.14%), Postives = 230/350 (65.71%), Query Frame = 1
Query: 961 WKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
++ K K G + + +Y+ Y F GA +++ D + V S A+G A S + KA+ +A L I+R+ AID + +G PE+ GN+ F ++HF+YP+R +V VL+GL L++ GQ++ALVG SGCGKST IQLLER+YDP QG V+LD D K LN+ W+R+QIG+V QEP LF+ S+A+NI YG NS V E + + AK ANIH FI LP+ Y T G +G LSGGQKQRI IARA+ P +LLLDEATSALDT+SE +VQEALD+A+E TC+V+AHRLSTI+NAD I + +NGVVVE GTH++L+N +G YY L
Sbjct: 656 YQNAKKKAHIFGLTFSFSQAMIYFAYAGCFRFGAWLIEQKMMDFEGVYLVISAVMYGAMAVGEANSFTPNYAKAKISASHVLMLINRVPAIDNESEEGEKPED-FEGNVRFHDVHFKYPSRPDVPVLQGLRLRVKKGQSLALVGSSGCGKSTTIQLLERFYDPM------QGAVMLDDKDAKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYGDNSRQVTQEEIERAAKAANIHSFIQELPQKYLTQAGDKGTQLSGGQKQRIAIARAILRNPKLLLLDEATSALDTESEKIVQEALDKAREGRTCIVVAHRLSTIQNADVIAVFQNGVVVEQGTHQQLLNQQGVYYTL 998 HSP 2 Score: 104.76 bits (260), Expect = 1.879e-116 Identity = 83/315 (26.35%), Postives = 146/315 (46.35%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHF 928
+RNAD+I +NGKI+E G H+ L+ +G+Y S +E K+ S F ++ +++ E Y++ GV A I G + P ++I++++ +V + + L+ + G + + + K+GE LT RLR ++L+Q+ ++D+P+N G LT RLA + + V+ A G++++ + + NL S+ I F Y W+L+LL L +P +A+ G +Q K+ G + L AG + E + NIRTV SL+ + F
Sbjct: 385 IRNADVIAGFQNGKIVELGTHDELMGMKGVY------------------------------------QSLVTMQEEKVPDVS-------FFTVLGLNKTEWPYMVLGVFCAIINGGMQPAFAIIFSKIISV-------GQVQTERTNFFSLMFAVIGAVSFVALFLQGYSFGKSGEILTMRLRYRAFRAMLRQDPGWYDDPKNSVGALTTRLATDTAQVQGATGVRMATLAQNVANLGTSIIISFVYGWQLTLLILSIVPIMAVAGAIQMKMLGGHAVKDKKELELAG-----KVATEAIENIRTVVSLTRESKF 644 HSP 3 Score: 301.982 bits (772), Expect = 9.875e-90 Identity = 156/343 (45.48%), Postives = 219/343 (63.85%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K + + G +Y Y + F+ G+ + + + +L+ VF + +G+ Q AR AA K ID +ID+ +G P+ + GNIEF+N+HF YP+R +V VL G++LKI +GQT+ALVG SGCGKST +QLL+R+YDP +G V +D HDI+++N+ +R IG+V QEP LF S+A+NI YG DV E + + + AN +DFI+ LP+ + T+VG RG +SGGQKQRI IARAL P ILLLDEATSALDT+SE +VQ ALD+ + T +++AHRLSTI+NAD I +NG +VE GTH+EL+ ++G Y L
Sbjct: 84 KAIMVNISVGFVYFMIYMSYALAFWYGSTLIIAKEYQVGNLLTVFFAVIIGAFGIGQTSPNIQAFASARGAAHKVFSIIDHKPSIDSFSEEGYKPD-VVKGNIEFRNIHFNYPSRQDVKVLNGMNLKIRSGQTIALVGSSGCGKSTTVQLLQRFYDPQ------EGTVTIDDHDIRSMNVRCLRELIGVVSQEPVLFATSIAENIRYG-REDVTQEEIEQATREANAYDFIMKLPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAIVQAALDKVRLGRTTIIVAHRLSTIRNADVIAGFQNGKIVELGTHDELMGMKGVYQSL 418
BLAST of Multidrug resistance protein 1 vs. Ensembl Cavefish
Match: abcb5 (ATP-binding cassette, sub-family B (MDR/TAP), member 5 [Source:ZFIN;Acc:ZDB-GENE-030131-6414]) HSP 1 Score: 325.094 bits (832), Expect = 2.776e-115 Identity = 166/338 (49.11%), Postives = 224/338 (66.27%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEE-KLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G LA + Y+V VF G+ + T ++ VFS + ++G++ S A D KA+ AA + L +++ ID + + G+IEF+++HF YPTR N+ +L+GL++ + GQT+ALVG SGCGKST IQLLER+Y+P GQV DG D + LNL+W+R+Q+GLV QEP LF+ ++ +NI YG NS V E +++ A ANIH+FI LPE YNT VG +G LSGGQKQRI IARAL KP +LLLDEATSALDT+SE +VQ+ALD A++ TC+VIAHRL+T++NAD I +I+NG VVE G H EL+ G YY L
Sbjct: 930 GITFALAQAIPYFVNAAVFRFGSWLIAHCHTQFENVFLVFSVIVFAAMSIGQSSSFAPDFAKAKAAAGRILALLEKTPEIDIYSEAGDKPINFKGDIEFRDVHFFYPTRPNIKILQGLNVSVTQGQTLALVGGSGCGKSTSIQLLERFYNP------AGGQVFADGMDTRGLNLAWLRSQLGLVSQEPILFDCTITENIQYGDNSRVVSQEEVVEAAISANIHNFISDLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRKPKVLLLDEATSALDTESEKIVQKALDEARKGRTCIVIAHRLTTVQNADIIAVIQNGQVVEQGMHSELMAKHGAYYAL 1261 HSP 2 Score: 111.694 bits (278), Expect = 2.776e-115 Identity = 94/353 (26.63%), Postives = 173/353 (49.01%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLS------STAN---------------------------EEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLV--LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQ-RLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
+R AD+I K+G+++EQG H L++ +G+Y ++ Q + + + S+ + D + S +TAN + K EK + F R++ +++ E YL+ G +A+ + G V+P ++++A++ VF+ PD + + + L+ LL L+ G + + + K+GE LT RLR+ ++L+Q++++FD+ N GVLT +LA +ASLVK AAG +L + I L ++ + F+++W+L+L+ L P + +Q + G + S + E + N +TV SL+ +D F K+ DSL
Sbjct: 567 IRTADVIAGFKDGEVVEQGTHGELMSKKGVYHSLVMQQTAGRSADDEAADENVSEGESLDDLSDAEHSDDLMDVTTANGGFARSSLRRSISLRSKRSRSSSKSKSKRTNKAEKEEESVPDVPFSRILALNKSEWPYLLVGTLASFVGGGVYPAVAILFAKIIGVFSE----PDPEVKRQKALMFSLLFLLVGAVAFLTFFFQGYMFGKSGEILTMRLRSQAFKAILRQDISWFDDHNNAVGVLTTKLATDASLVKGAAGSRLGLATNTICALVIAMIVAFFHSWQLTLMILACTPILTGANFIQMRAMAGHTSKDQSALEMSGRISTETVENFKTVVSLTKEDVFFRKFNDSL 915 HSP 3 Score: 295.434 bits (755), Expect = 7.828e-88 Identity = 158/340 (46.47%), Postives = 217/340 (63.82%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFL--DKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQN 2013
GL ++ Y + F+ G D + ++ VF + +LG+ + KAR AA TID ID+ +G P+ + G+IEF+N+HF YP+R +V +L+G+ LK+ G+T+ALVG SGCGKST IQLL+R+YDP G+V LDG DI++LN+ W+R +G+V QEP LF ++A+NI YG D + + + + AN ++FI LP+G NT+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDTQSE +VQ ALD+A+ T +VIAHRLSTI+ AD I ++G VVE GTH EL++ +G Y+ L +Q
Sbjct: 273 GLTQFFIFGAYALAFWYGTKLTVDDPVNYSIGKVIIVFFSVMIGAFSLGQGAPNLESVAKARGAAYSIYNTIDMPRPIDSSSEEGYKPDS-VRGDIEFRNVHFSYPSRKDVKILQGMSLKVPHGKTIALVGASGCGKSTTIQLLQRFYDPEA------GEVTLDGRDIRSLNVRWLRENMGIVSQEPVLFGTTIAENIRYGREDATD-QDIDRAVREANAYEFISKLPDGLNTMVGERGAQLSGGQKQRIAIARALVKNPKILLLDEATSALDTQSEAIVQAALDKARAGRTTIVIAHRLSTIRTADVIAGFKDGEVVEQGTHGELMSKKGVYHSLVMQQ 604 HSP 4 Score: 49.6766 bits (117), Expect = 7.828e-88 Identity = 39/140 (27.86%), Postives = 68/140 (48.57%), Query Frame = 2
Query: 536 TTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK-LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
T R+R +VL Q MA+FD + G L RL + + + G ++ +F++ A IGF Y W+L+L+ + P +A + + K L+T + + ++ E+L IRTV + + Q +KY +L
Sbjct: 117 TKRIREKYFHAVLHQPMAWFD--THPIGELNTRLTDDINTINDGLGDKICIFVQFFCTFLAGFIIGFIYGWKLTLVIMSVSPLLAASAAVWSKILATLTSKELSAYAKAGAVAEEILVAIRTVVAFNGQQKAAEKYEKNL 254
BLAST of Multidrug resistance protein 1 vs. Ensembl Cavefish
Match: abcb5 (ATP-binding cassette, sub-family B (MDR/TAP), member 5 [Source:ZFIN;Acc:ZDB-GENE-030131-6414]) HSP 1 Score: 321.627 bits (823), Expect = 6.819e-113 Identity = 170/350 (48.57%), Postives = 228/350 (65.14%), Query Frame = 1
Query: 961 WKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHK--GVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+K K G LA ++ Y+V F GA + + VFS +ST +G+ S D KA+ AA + + +++ ID + GV P G+IEF ++HF YPT+ +V +L+GL++ + GQT+ALVG SGCGKST IQLLER+Y+P GQV DG D + LNL+W+R+Q+GLV QEP LF+ ++ +NI YG NS V E +++ AK ANIH+FIL+LPE YNT VG +G LSGGQKQRI IARAL P +LLLDEATSALDT+SE +VQ+ALD A++ TC+VIAHRL+T++NAD I +I+NG VVE G H EL+ +G YY L
Sbjct: 897 YKSALWKAPLYGMSFALAQASSYFVRAAFFRFGAWLIAHCYAQYEDIYLVFSVLVLSTMNVGQTSSANLDFAKAKAAAGRIIALLEKKPEIDIYSDAGVKPT-NFRGDIEFHDVHFSYPTQPDVRILQGLNVSVRQGQTLALVGGSGCGKSTSIQLLERFYNP------AGGQVFADGMDTRGLNLAWLRSQLGLVSQEPILFDCTITENIQYGDNSRVVSQEEVVEAAKKANIHEFILNLPERYNTRVGDKGTQLSGGQKQRIAIARALVRNPKVLLLDEATSALDTESEKIVQKALDEARKGRTCIVIAHRLTTVQNADIIAVIQNGQVVEQGMHSELMAKQGAYYAL 1239 HSP 2 Score: 107.071 bits (266), Expect = 6.819e-113 Identity = 71/208 (34.13%), Postives = 116/208 (55.77%), Query Frame = 2
Query: 353 FPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGI-------MQGKLSTGQR-LSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
+PC +++A++ VFA P++ K LL + G + + + L K+GE+LT RLR+ ++L+Q++++FD+ N GVLT +LA +ASLVK AAG +LS+ + +L S+ + ++W+L+LL L +P LTG M+G S QR L T+G + E + N RTV +L+ ++ F K+ DSL
Sbjct: 695 YPCVGILFAKIIGVFAE--LDPEVKRQKSMMFSLLFFLVGTMAFLTYFFQGYMLGKSGESLTMRLRSQAFKAILRQDISWFDDYDNAVGVLTTKLATDASLVKGAAGSRLSLATSSFCSLGVSVIVALCFSWQLTLLILACVPF--LTGAMFIQTRSMKGHASKDQRALETSG-----KISTETVENFRTVVALTKEEVFMQKFSDSL 893 HSP 3 Score: 302.753 bits (774), Expect = 8.190e-89 Identity = 161/342 (47.08%), Postives = 221/342 (64.62%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGA-IFLDKGKTDMIS-LMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN 2019
G+ L+ + + F+ G + +D+ + I ++ VF + +LG+ + KAR AA TID ID+ KG P+ ++G+IEFK +HF YP+R +V +L+G+ LK+ G+T+ALVG SGCGKST IQLL+R+YDP G+V LDG DI+ LN+ W+R +G+V QEP LF ++A+NI YG D + + + + AN ++FI LP+G NT+VG+RG LSGGQKQRI IARAL P ILLLDEATSALDTQSE +VQ ALD+A+ T +VIAHRLSTI+ AD I ++G VVE GTH EL+N +G YY L +Q +
Sbjct: 254 GITQFLLFSTFALAFWYGTKLSVDEPENYSIGKVLTVFFSVMIGALSLGQGAPNLESIAKARGAAYSIYSTIDMPRPIDSSSIKGYKPDS-VSGDIEFKKIHFSYPSRKDVKILQGMSLKVPHGKTIALVGASGCGKSTTIQLLQRFYDP------DAGEVTLDGRDIRCLNVRWLRENMGIVSQEPVLFGTTIAENIRYGREDATD-QDIDRAVREANAYEFISKLPDGLNTMVGERGAQLSGGQKQRIAIARALVKNPKILLLDEATSALDTQSEAIVQAALDKARAGRTTIVIAHRLSTIRTADVIAGFKDGEVVEQGTHRELMNKKGVYYSLVMQQTS 587
BLAST of Multidrug resistance protein 1 vs. Ensembl Sea Lamprey
Match: ABCB1 (ATP binding cassette subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:40]) HSP 1 Score: 334.339 bits (856), Expect = 4.844e-102 Identity = 171/348 (49.14%), Postives = 227/348 (65.23%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE-EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSD-VDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K K K F G G + +Y F GA + G+ + ++ VFS A+G+ S A D KA+ +A + AID++ + E GN+EF+++ F YP R NV VL+GL LK+ GQT+ALVG SGCGKST +QLLER+YD G VL+DG D+++L++ W+R Q+G+V QEP LF+ S+A+NI YG NS V + ++ A+ ANIH FI SLPE YNT VG +G LSGGQKQRI IARAL +P ILLLDEATSALDT+SE +VQEALDRA+E TC+VIAHRLST++ ADKI +I+NG V+E GTH++L+ +G Y+ L
Sbjct: 712 KTAKKKSQFYGLTYGFSQGVVYLAQAAAFRFGAFLVTAGRMEFENVFLVFSAIVFGAMAVGQTSSFAPDYAKAKTSANHLFYLFQLIPAIDSYSDEGEKLEDCEGNVEFQSVGFNYPMRPNVEVLKGLSLKVENGQTLALVGSSGCGKSTSVQLLERFYDTL------SGNVLIDGKDVRSLHIQWLRAQMGIVSQEPVLFDCSMAENIAYGDNSRIVPQDEIVAAARAANIHTFIDSLPEKYNTKVGDKGTQLSGGQKQRIAIARALVRQPKILLLDEATSALDTESEKIVQEALDRAREGRTCIVIAHRLSTVQTADKIAVIQNGQVIEQGTHQQLLAKKGAYHLL 1053 HSP 2 Score: 267.314 bits (682), Expect = 1.328e-77 Identity = 150/340 (44.12%), Postives = 208/340 (61.18%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGA-IFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDR---LTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRAN----VSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G + +Y Y + F+ G+ + L+ + ++M VF + +G+A + AR AA + IDR + + H + K + FR T N VL+G++L++ +GQTVALVG SGCGKST IQLL+R+YDP QG +++DG D++ LNL +R IG+V QEP LF ++A+NI +G + V E + + A+ AN +DFI +PE +NT+VG RG LSGGQKQRI IARAL P +LLLDEATSALD +SE +VQEALD+A+E T +VIAHRLSTI+NAD I + GV+VE GTH+EL+ G Y+ L
Sbjct: 86 GFTMFIVYASYSLAFWYGSRLVLEDTSYTIGNVMIVFFAVIIGAFGIGQAAPFLEAISVARGAAYTIFEIIDRTIHMYPFNTHNSSLRNRK-------RCTWFREHTLVNSIAFCQVLKGVNLQVKSGQTVALVGSSGCGKSTTIQLLQRFYDPQ------QGTIMVDGRDVRTLNLRSLRQLIGVVSQEPVLFATTIAENIRFG-HEKVTMEDIERAARNANAYDFISQMPERFNTLVGDRGAQLSGGQKQRIAIARALIRNPKLLLLDEATSALDGESEAIVQEALDKAREGRTTIVIAHRLSTIRNADIIAGFDGGVIVELGTHDELMKRNGVYHTL 411 HSP 3 Score: 122.865 bits (307), Expect = 3.554e-29 Identity = 104/354 (29.38%), Postives = 177/354 (50.00%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPT--DAATRRLSSTANEEEFKLEKPS--------KIQMIK----DFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRT--LVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQR------LSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFWA 997
+RNADII G I+E G H+ L+ G+Y ++ Q +K++ E + +PT A R LS ++ +E L K +I +K F +++ +++ E Y+ G + A + GA+ P ++I++ + VFA DL+ + ++ LL L+ G + + + ++GE LT +LR+ + ++L+Q+M +FD+P+N G LT RLA +AS V+ A G +L+ + I N+ ++ I F Y WEL+LL L +P + G ++ + TGQ L AG + E + NIRTV SL+ + Y DSL+ K + F+
Sbjct: 378 IRNADIIAGFDGGVIVELGTHDELMKRNGVYHTLVSMQTFHQKDDNGIEDIKAKRLDSPTGDKAFFRSLSQQSHAKESDLAKEDGEDNKETEQILEVKIPKVSFWKVLALNKKEWPYITLGTLCAGVNGALQPAFAVIFSRIIGVFAE----TDLVKREEQSNLYSLLFLVLGIVSFVTFFLQGFLFGRSGELLTMKLRSMGLRAMLRQDMMWFDDPKNSTGALTTRLATDASQVQGATGARLATIAQNIANMGTAIVISFVYGWELTLLILAIVPFVGAAGFLEMQALTGQANRDKKLLEEAG-----KIATEAVENIRTVASLTRERTLEKIYQDSLEGPAKTAKKKSQFYG 722
BLAST of Multidrug resistance protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001786.1 (pep scaffold:Pmarinus_7.0:GL477870:201625:214977:-1 gene:ENSPMAG00000001622.1 transcript:ENSPMAT00000001786.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 318.546 bits (815), Expect = 8.499e-102 Identity = 156/349 (44.70%), Postives = 230/349 (65.90%), Query Frame = 1
Query: 961 WKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH-KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSD-VDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
++ IK + G L + Y VF +G + +G+ + +VF A+G+A+++A + +A+ +A + L + R AID++ +G + + G ++ +HFRYPTR + VLRG+ L++ GQT+ALVG SG GKST++QLL R+YD GQ+LL+G +++ LNL W+R Q+G+V QEP LF S+A+NI YG S V + ++ A+ AN+HDF+ SLP+ Y+TVVG+RG LSGGQKQR+ IARAL P +LLLDEATSALD +SE VVQ+AL++AQ+ TC+VIAHRLST++ AD I ++++G + E G+HEEL++ RG YY L
Sbjct: 136 YRVIKRRGYLFSVTFGFTQGILCFAYAAVFRLGGFLVAQGELTFQDVYKVFGAIIFGALAVGQAMAMAPNYGRAKVSAARILALLRREMAIDSYSEGGIQPDAFDGELQLSGVHFRYPTRPHAEVLRGVSLRVAPGQTLALVGPSGSGKSTIMQLLLRFYDS------SAGQLLLNGVEVRQLNLGWLRRQLGVVSQEPVLFGCSIAENIAYGDVSRAVSRDEVVAAARAANLHDFVESLPQAYDTVVGERGAQLSGGQKQRVAIARALLRDPRVLLLDEATSALDAESEKVVQDALEKAQQGRTCIVIAHRLSTVRAADVIAVLQDGDICELGSHEELLSARGLYYRL 478 HSP 2 Score: 59.3066 bits (142), Expect = 1.474e-9 Identity = 37/118 (31.36%), Postives = 64/118 (54.24%), Query Frame = 2
Query: 578 QEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTA-GXXXXXXXXXXXXNNIRTVNSLSLQDHF 928
QE+ +F +N G LTA+L+ +A+ V+ A G + + ++ + L+ L I W+L+LL L F+P + G++Q L + + +S + E + NIRTV SL L++ F
Sbjct: 7 QEIRWFYNHKNNTGALTAQLSTDAAQVQGATGRRAGMLVQNVSGLATGLLIALLVGWKLALLMLAFMPFMVGAGLVQSVLQGSEATTIKRAYEQASKISTEAVQNIRTVASLCLEEKF 124
BLAST of Multidrug resistance protein 1 vs. Ensembl Sea Lamprey
Match: abcb11b (ATP-binding cassette, sub-family B (MDR/TAP), member 11b [Source:ZFIN;Acc:ZDB-GENE-050517-14]) HSP 1 Score: 317.775 bits (813), Expect = 1.197e-94 Identity = 161/340 (47.35%), Postives = 220/340 (64.71%), Query Frame = 1
Query: 991 LGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAH--KGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSN-SDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G + S +++ Y F G + + RVFS S ALGRA S A D KA+ +A + + DR AID+ KGV + G++ F N F YP+R + VL GL + + GQT+ALVG SGCGKST +QLLER+YDP GQVL+DG D + +N+ ++R++IG+V QEP LF+ S+ADNI YG+N ++ ++ +I +K A +HDF++ LPE Y T VG +G LS G+KQR+ IARA+ P ILLLDEATSALDT+SE VQ ALD+A++ TC+VIAHRLSTI+NAD+I +I G+V+E GTH EL++ +G YY L
Sbjct: 967 FGATFSFSQSVIFFTYAASFRYGGFLVAHDGLKFPLVFRVFSALVFSGTALGRASSYAPDYAKAKISAARLFKLFDRTPAIDSSPDKGV-SWDGFRGDVTFTNCTFTYPSRPDTQVLNGLSVSVQPGQTLALVGTSGCGKSTSVQLLERFYDP------DGGQVLIDGRDSRTVNVGFLRSKIGIVSQEPVLFDCSIADNIRYGANFRELTWDEVINASKAAQLHDFVMGLPEKYETNVGDKGAQLSRGEKQRVAIARAIIRDPRILLLDEATSALDTESEQTVQSALDQARQGRTCIVIAHRLSTIQNADQIAVISQGLVIEKGTHNELMDAQGAYYKL 1299 HSP 2 Score: 251.521 bits (641), Expect = 1.563e-71 Identity = 152/344 (44.19%), Postives = 219/344 (63.66%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGA-IFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K + LG G ++ Y + F+ G+ + L++ + +L++VF + LG+A + R AA IDR ID + G + + K+ G+IEF N+ F YPTR +++ L +LK+NAG+T A VG SG GKST +QL++R+YDP +G+V LDGHDI++LNL W+R+ IG+V+QEP LF ++A+NI YG + +V + + A+ AN ++FI+ LP ++T+VG+ GG +SGGQKQRI IARAL P ILLLD+ATSALD +SE VVQ ALD+ ++ T + IAHRLSTI +AD IV E G VE G+HE L+ +G Y+ L
Sbjct: 321 KGMILGFFQGYMWFIIFLCYALAFWYGSNLVLEEEEYSPGTLLQVFFGVLVGAINLGQASPCLEAFASGRGAATHVFNIIDREPIIDCMSDDGNILQ-KVKGDIEFHNVKFSYPTRLDLTALHSFNLKVNAGETTAFVGPSGAGKSTAMQLIQRFYDP------QEGKVTLDGHDIRSLNLRWMRSLIGVVEQEPILFATTIAENIRYGRD-NVTVSEVEQAARRANAYNFIMELPHKFDTMVGEGGGQMSGGQKQRIAIARALVRNPRILLLDQATSALDNESEAVVQSALDKVRKGCTTISIAHRLSTIHSADVIVGFELGCAVERGSHEALMARQGVYFTL 656 HSP 3 Score: 62.003 bits (149), Expect = 3.994e-10 Identity = 62/265 (23.40%), Postives = 120/265 (45.28%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAA-------------------TRRLSSTANEEEFKLEKPSKIQMI----------KDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLV----LLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIE 697
+ +AD+IV + G +E+G+HE L+ QG+Y+ ++ Q + + E + P + +R STA E + K+ + R+++ + E Y++ G + A+I G + P +++++E+ F L + R ++ LL ++ G + + + K+GE LT RLR +++L+Q++ +FD+ +N PG LT RLA +AS V+ G+++ E
Sbjct: 623 IHSADVIVGFELGCAVERGSHEALMARQGVYFTLVTLQSQSDHMLGSKG-DDEDRIEEPIEKVRSFSRGSYQNSLRASLRNRSRSRKSTAKTEPSASKPGVKVNKVTDEEEEDEEHAPVTRILKYNAPEWPYMVFGAVGAAINGGIQPVFAILFSEILGTFTLPTE------EEQRNMINLTCLLFVLIGIVSFVTYFLQGYMFSKSGELLTRRLRRCGFTAMLRQDVGWFDDLKNSPGALTTRLATDASQVQ---GVKICYVFE 877
BLAST of Multidrug resistance protein 1 vs. Ensembl Sea Lamprey
Match: abcb10 (ATP-binding cassette, sub-family B (MDR/TAP), member 10 [Source:ZFIN;Acc:ZDB-GENE-040525-2]) HSP 1 Score: 252.677 bits (644), Expect = 2.286e-75 Identity = 140/281 (49.82%), Postives = 184/281 (65.48%), Query Frame = 1
Query: 1138 ALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKG-VVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSD--VDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEEL 1971
++G S + K + Q +DR I +G VVP + L G IEF+ +HF YPTR V R LDL + AGQ A+VG SGCGKSTL+ LL R YDP +GQVL+DG D++ +N SW+R+QIG V QEP LF+ S+A+NI YG+ + + + A+ AN + FI P G++TVVG++G LSGGQKQRI IARA+ P ILLLDEATSALD++SE +VQEALDR T LVIAHRLSTI+ AD+I ++E G V ++GT+ +L
Sbjct: 304 SIGGLSSFYSELMKGLGTGSRIWQLLDRQPTIPLGEGQVVPLQALRGEIEFRGVHFAYPTRETAPVFRSLDLAVPAGQVTAVVGPSGCGKSTLLSLLLRLYDPQ------KGQVLIDGQDVREVNPSWLRSQIGTVSQEPILFSCSIAENIAYGAANPEAASKADIARAAQAANAYGFIEGFPSGFDTVVGEKGVLLSGGQKQRIAIARAILKNPNILLLDEATSALDSESESLVQEALDRLMTGRTVLVIAHRLSTIQGADRIAVLERGRVAQAGTYAQL 578 HSP 2 Score: 50.0618 bits (118), Expect = 1.654e-6 Identity = 35/148 (23.65%), Postives = 76/148 (51.35%), Query Frame = 2
Query: 500 KAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK-LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKY 940
+ + + +G+ + RLR + ++++QE+ +FD + G L RL+ + +L+ A LS + ++ ++ + + FY + +L+ L +P IAL ++ G+ L + + ++ + E + NIRTV S + ++ KY
Sbjct: 92 RVYLMQVSGQRIVQRLRDSLFRAIMRQELGFFDRTRT--GELVNRLSADTALMGRAVTENLSDGLRSVAQVTVGIGMMFYVSPKLATFVLGVVPPIALIAVVYGRYLRRITKRTQDSLAEATQVAEERIGNIRTVRSFAKEELEMQKY 237
BLAST of Multidrug resistance protein 1 vs. Ensembl Sea Lamprey
Match: abcb8 (ATP-binding cassette, sub-family B (MDR/TAP), member 8 [Source:NCBI gene;Acc:548340]) HSP 1 Score: 245.743 bits (626), Expect = 1.210e-72 Identity = 124/253 (49.01%), Postives = 164/253 (64.82%), Query Frame = 1
Query: 1246 GVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQ-IGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G++P G++ F N+ F YPTR VL +L + QT+A+VG SG GKST+ LLER+YDP G + LDG D++ L+ SW+R + IG + QEP LF ++ +NI +G D E + A++AN DFI S P+GYNTVVG+RG LSGGQKQR+ IARAL +P +L+LDEATSALD ++E VQEAL+RA T LVIAHRLST+ A+ I ++ G V E GTH EL+ G Y +L
Sbjct: 371 GIIPHHSCLGHVRFNNVTFSYPTRPGQVVLHNFNLNLPPSQTIAIVGLSGGGKSTVAALLERFYDP------ASGSITLDGKDLRTLDPSWLRGRVIGFINQEPVLFGTTIIENIRFGKPGATDDE-VYAAARLANADDFIRSFPDGYNTVVGERGATLSGGQKQRVAIARALIKQPAVLVLDEATSALDAEAEGAVQEALERAAHGRTVLVIAHRLSTVAGANLICVVAGGTVQEMGTHAELLKKGGLYAEL 616
BLAST of Multidrug resistance protein 1 vs. Ensembl Yeast
Match: MDL2 (Mitochondrial inner membrane half-type ABC transporter; required for respiratory growth at high temperature; localizes to vacuole membrane in response to H2O2; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis [Source:SGD;Acc:S000006191]) HSP 1 Score: 201.445 bits (511), Expect = 9.604e-56 Identity = 114/266 (42.86%), Postives = 156/266 (58.65%), Query Frame = 1
Query: 1189 AARKTLQTIDRLTAIDAHKG--VVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDR--AQENTTCLVIAHRLSTIKNADKIVII-ENGVVVESGTHEEL 1971
AA + + DR +I G P+ G IEFK++ F YPTR +V + + L+ KI G +V +VG SG GKST+ LL RYY+P G + +D DI LN +R IG+V+QEP L + ++ DNI YG E + VAK H+FI P Y+TV+G G LSGGQKQRI IARAL KP IL+LDEATSALD +SE + + ++ T + IAHRLSTI+ ++ ++++ +G VVE G +EL
Sbjct: 417 AASRLFELTDRKPSISPTVGHKYKPDR---GVIEFKDVSFSYPTRPSVQIFKNLNFKIAPGSSVCIVGPSGRGKSTIALLLLRYYNPTT------GTITIDNQDISKLNCKSLRRHIGIVQQEPVLMSGTIRDNITYGLTYTPTKEEIRSVAKQCFCHNFITKFPNTYDTVIGPHGTLLSGGQKQRIAIARALIKKPTILILDEATSALDVESEGAINYTFGQLMKSKSMTIVSIAHRLSTIRRSENVIVLGHDGSVVEMGKFKEL 673
BLAST of Multidrug resistance protein 1 vs. Ensembl Yeast
Match: MDL1 (Mitochondrial inner membrane half-type ABC transporter; mediates export of peptides generated upon proteolysis of mitochondrial proteins; plays a role in the regulation of cellular resistance to oxidative stress [Source:SGD;Acc:S000004178]) HSP 1 Score: 192.2 bits (487), Expect = 7.789e-53 Identity = 125/321 (38.94%), Postives = 172/321 (53.58%), Query Frame = 1
Query: 1078 GKTDMISLMRV--------------FSCFTMSTAALGRAL----SLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVA-KMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENT-TCLVIAHRLSTIKNADKIVII-ENGVVVESGTHEELI 1974
G T M+SL+ V S F M G +L S + K AA + + DR I G P I FKN+ F YPTR + + L++ I G+ V VG SG GKST+ LL RYYD G + DI+ NL R IG V+QEP LFN ++ DNI+Y ++ + + I+ A AN F+ + P+G T+VG RG LSGGQKQRI +ARA P +L+LDEATSALD+QSE +V + L R E T + IAHRLSTIK++ +++++ ++G VVE+G+ +LI
Sbjct: 347 GNTAMLSLLLVGTSMIQSGSMTVGELSSFMMYAVYTGSSLFGLSSFYSELMKGAGAAARVFELNDRKPLIRPTIGKDPVSLAQKPIVFKNVSFTYPTRPKHQIFKDLNITIKPGEHVCAVGPSGSGKSTIASLLLRYYD------VNSGSIEFGDEDIRNFNLRKYRRLIGYVQQEPLLFNGTILDNILYCIPPEIAEQDDRIRRAIGKANCTKFLANFPDGLQTMVGARGAQLSGGQKQRIALARAFLLDPAVLILDEATSALDSQSEEIVAKNLQRRVERGFTTISIAHRLSTIKHSTRVIVLGKHGSVVETGSFRDLI 661
BLAST of Multidrug resistance protein 1 vs. Ensembl Yeast
Match: ATM1 (Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; human homolog ABCB7 can complement yeast null mutant [Source:SGD;Acc:S000004916]) HSP 1 Score: 181.8 bits (460), Expect = 2.584e-49 Identity = 103/260 (39.62%), Postives = 156/260 (60.00%), Query Frame = 1
Query: 1234 DAHKGVVPEEKLTGNIEFKNLHFRY-PTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQEN-----TTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYY 1995
+A + ++ E + +I F+N+ F Y P R +L+ I AG A+VG SG GKST+++L+ R+YDP G++L++G DIK ++ +R IG+V Q+ LFN ++ +N+ +G D E +I V + A + I LP+G++T+VG+RG +SGG+KQR+ IAR L I+ DEATSALDT +E Q L ++N T + IAHRL TI +ADKI++++NG V E G H EL+ + G Y
Sbjct: 421 NAERPLMLPENVPYDITFENVTFGYHPDR---KILKNASFTIPAGWKTAIVGSSGSGKSTILKLVFRFYDP------ESGRILINGRDIKEYDIDALRKVIGVVPQDTPLFNDTIWENVKFGRIDATD-EEVITVVEKAQLAPLIKKLPQGFDTIVGERGLMISGGEKQRLAIARVLLKNARIMFFDEATSALDTHTE---QALLRTIRDNFTSGSRTSVYIAHRLRTIADADKIIVLDNGRVREEGKHLELLAMPGSLY 667
BLAST of Multidrug resistance protein 1 vs. Ensembl Yeast
Match: STE6 (Plasma membrane ATP-binding cassette (ABC) transporter; required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells; human homolog ABCB1 mediates multidrug resistance in many chemotherapy-resistant tumors by effluxing toxic compounds from the cell [Source:SGD;Acc:S000001692]) HSP 1 Score: 178.333 bits (451), Expect = 3.999e-47 Identity = 111/324 (34.26%), Postives = 176/324 (54.32%), Query Frame = 1
Query: 1048 FFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTI------DRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV--------DYEHMIKVA-KMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELI 1974
F+ G+ + KGK ++ ++ F M + L L +K A K + + + L AH+ P + T ++ F N+ F YP+R + +VL+ + L +AGQ +VG SG GKSTL LL R+YD + G + ++GH+I+ ++ + I +V+Q +LFN ++ NI+ GS V + H+IK A +MA + FIL LP+G T++G G LSGGQ+QR+ IARA PIL LDEA SALD ++ +A+ ++ T +++ H LS I++ D + +++ G VVESGT EL+
Sbjct: 276 FWFGSAMIKKGKLNINDVITCFHSCIMLGSTLNNTLHQIVVLQKGGVAMEKIMTLLKDGSKRNPLNKTVAHQ--FPLDYATSDLTFANVSFSYPSRPSEAVLKNVSLNFSAGQFTFIVGKSGSGKSTLSNLLLRFYDGY------NGSISINGHNIQTIDQKLLIENITVVEQRCTLFNDTLRKNILLGSTDSVRNADCSTNENRHLIKDACQMALLDRFILDLPDGLETLIGTGGVTLSGGQQQRVAIARAFIRDTPILFLDEAVSALDIVHRNLLMKAIRHWRKGKTTIILTHELSQIESDDYLYLMKEGEVVESGTQSELL 591 HSP 2 Score: 169.474 bits (428), Expect = 3.007e-44 Identity = 88/241 (36.51%), Postives = 140/241 (58.09%), Query Frame = 1
Query: 1279 IEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+ +NL F YP+ V + ++ + GQT+ ++G SG GKSTL+ LL + Y+ V G++ +DG D+ NL+ +R +I +V+Q+P LFN ++ DN+ YG ++ M K IHDF++S P+G +T + LSGGQ QR+CIARAL K IL+LDE TSALD+ S ++ E + + +VI H +++ + I ++++G VVE G + L N RG + +
Sbjct: 1052 VSIQNLTFAYPSAPTAFVYKNMNFDMFCGQTLGIIGESGTGKSTLVLLLTKLYNCEV------GKIKIDGTDVNDWNLTSLRKEISVVEQKPLLFNGTIRDNLTYGLQDEILEIEMYDALKYVGIHDFVISSPQGLDTRIDTT--LLSGGQAQRLCIARALLRKSKILILDECTSALDSVSSSIINEIVKKGPPALLTMVITHSEQMMRSCNSIAVLKDGKVVERGNFDTLYNNRGELFQI 1284
BLAST of Multidrug resistance protein 1 vs. Ensembl Yeast
Match: YKR104W (Putative transporter of the MRP subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds; MRP stands for multidrug resistance-associated protein [Source:SGD;Acc:S000001812]) HSP 1 Score: 130.183 bits (326), Expect = 5.406e-34 Identity = 85/259 (32.82%), Postives = 136/259 (52.51%), Query Frame = 1
Query: 1270 TGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNI-IYGSNSDVD-YEHMIKVAKMANIHDFILSLPE---------------GYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYY 1995
TG++E KNL RY ++ L + K+ AG V +VG +G GKS++I + R D + G + +D DIK + L +RN I + Q+P+LF+ +V N+ + SDV Y + KV + + L + NTVV G +LS GQ+Q +C+AR++ I+L+DEAT+++D S+ +Q+ + +NTT L IAHRL ++ + DKI+++E G V E LI+ R +
Sbjct: 30 TGDVELKNLSLRYSPHSS-KALDNVSFKVKAGTKVGIVGRTGAGKSSIIAAIYRLSD------WENGTITIDNKDIKHIPLERLRNSISCIPQDPTLFDGTVRSNLDPFDRYSDVQIYGVLSKVGLIEECDELCLIFEQEQPNFSSHKLRNRFIDLNTVVKSGGSNLSQGQRQLLCLARSMLGARNIMLIDEATASIDYISDAKIQKTIRETMKNTTILTIAHRLRSVIDYDKILVMEMGRVKEYDHPYTLISDRNTIF 281
BLAST of Multidrug resistance protein 1 vs. Ensembl Nematostella
Match: EDO49737 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RFK3]) HSP 1 Score: 325.479 bits (833), Expect = 4.386e-114 Identity = 168/339 (49.56%), Postives = 226/339 (66.67%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G GL + ++ F GA + +G+ DM +M+V C ++ G+ SL+ D +KAR AA K + +DR AID+ G+ P + G ++ +++ F+YPTR NV VLRGL L++N GQT+ALVG SGCGKST + LLER+YDP G++ +D +++ LNL W+R++IG+V QEP LF S+A NI YG NS +V + AK ANIH+FI LP+GY+T VG +G +SGGQKQRI IARAL PPILLLDEATSALDT+SE VVQ+ALD A E T ++IAHRLST+KNAD I +I++G V E GTH+EL+ + G Y L
Sbjct: 776 GASYGLTEAIMFLCNAACFRFGAYLIVQGEMDMPRVMKVVMCIVIAGLVAGQISSLSPDYQKARTAAGKIFKLLDRTPAIDSASENGLQPA-AVRGTVQVRSVRFKYPTRPNVKVLRGLSLEVNQGQTLALVGPSGCGKSTTVSLLERFYDPE------DGEMAIDNANVRQLNLKWLRSKIGIVSQEPVLFGYSIAQNIAYGDNSREVSMAEIETAAKAANIHNFICGLPKGYDTEVGDKGTLISGGQKQRIAIARALIRNPPILLLDEATSALDTESEKVVQDALDAASEGRTVIMIAHRLSTVKNADVICVIDHGRVAEQGTHQELMAMNGIYTGL 1107 HSP 2 Score: 105.531 bits (262), Expect = 4.386e-114 Identity = 94/322 (29.19%), Postives = 152/322 (47.20%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFK-LEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDG 964
+RNA +I +++G ++E+G+H L+ TD R+L + + K LE+ ++ +R++R++ + ++ GVI+A I G + +L+ E+ NVF L T D M + L+ L+ G F Q+ + + +GEALT ++R S+L+QEMA+FD+P + G LT LA AS VK AAG +L + + AS FY W+LSL+ FIP I L G + K TG + S + +E N+RT+ +L + F + Y S +DG
Sbjct: 482 IRNATVIAAIQDGVVVEKGSHNELM---------------------------------ATDGLYRQLITLQGKHNHKVLEEEAEP---GSALRVLRMNSDQWPVMVVGVISALINGLLPMSFALLLGEILNVFTLVNT--DEMKKEATFWALMFLVMGGASFFTQIFQNYMFAISGEALTVKIRRLSFKSLLRQEMAFFDDPFHTTGALTTALATHASDVKGAAGSRLGTLALGLSTVVASAIYAFYNGWKLSLVVCAFIPFIVLAGALHMKAFTGDHGGKDDYIESGKIAVEAFENVRTIATLGREHTFFEHY--SRSIDG 763 HSP 3 Score: 312.383 bits (799), Expect = 2.173e-93 Identity = 165/328 (50.30%), Postives = 217/328 (66.16%), Query Frame = 1
Query: 1024 LYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
++ Y + F+ GA+ + + L+ VF + LG+A + AR AA + IDR ID+ +G+ P + G+I+F ++HF+YP+R +V VL+GL L I +GQTVALVG SGCGKSTLI+L++R+YDP +G V +DG DI++LNL W+R IG+V QEP LF +VA+NI YG E + K KMAN HDFI +LP+GYNTVVG+RG +SGGQKQRI IARAL P +L+LDEATSALDT+SE +VQ ALD+A E T LVIAHRLSTI+NA I I++GVVVE G+H EL+ G Y L
Sbjct: 196 MFGSYSLAFWYGAVLVADKAINSGDLLVVFFSVMVGATQLGQAGPNIEAIATARGAAYELYSIIDRQPPIDSSSEEGLKPA-SVKGDIDFTDIHFQYPSRPDVKVLKGLHLTIRSGQTVALVGESGCGKSTLIKLVQRFYDP------AEGTVCMDGIDIRSLNLKWLRQHIGVVSQEPILFATTVAENIRYGREGITQAE-IEKATKMANAHDFIRNLPQGYNTVVGERGAQMSGGQKQRIAIARALVKNPTLLILDEATSALDTESEKIVQAALDKASEGRTTLVIAHRLSTIRNATVIAAIQDGVVVEKGSHNELMATDGLYRQL 515
BLAST of Multidrug resistance protein 1 vs. Ensembl Nematostella
Match: EDO48846 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RHG7]) HSP 1 Score: 318.161 bits (814), Expect = 1.648e-109 Identity = 161/341 (47.21%), Postives = 222/341 (65.10%), Query Frame = 1
Query: 988 FLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA--HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G G+ + +Y+ + F GA + + + M +M+V C ++ G + + D KA+ A + + +DR+ ID+ +G+ P + G ++ ++L FRYP R +V VLRGL L++ GQT+ALVG SGCGKST + LLER+YDP +G+V +D D++ LN+ W+R++IG+V QEP LF S+A NI YG NS +V + + A+ ANIHDFI LP+GY T VG +G LSGGQKQRI IARAL PPILLLDEATSALDT+SE VVQ+ALD A E T ++IAHRLST+KNAD I +I++G V E GTH+EL+ + G Y L
Sbjct: 505 LFGAGYGVTEAIMYFCFAACFRYGAHLMVEKEMTMEEVMKVVMCIMIAGMVAGELFAFSPDYLKAKVAGARIFKLVDRIPVIDSASDEGLTPS-TVQGTLQMRSLRFRYPARPDVKVLRGLSLEVKQGQTLALVGPSGCGKSTTVSLLERFYDPE------EGKVAVDNRDVRQLNIKWLRSKIGIVSQEPVLFGYSIAQNIAYGDNSREVSMKEIETAARAANIHDFISGLPKGYETEVGDKGTLLSGGQKQRIAIARALVKNPPILLLDEATSALDTESEKVVQDALDAASEGRTVIMIAHRLSTVKNADVICVIDHGRVAEHGTHQELMAMNGIYTGL 838 HSP 2 Score: 97.4413 bits (241), Expect = 1.648e-109 Identity = 94/335 (28.06%), Postives = 160/335 (47.76%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPE---SKTLTPTDA-----------ATRRLSSTANEEEFKLEKPSKIQMIK----DFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSL 952
VRNAD+I + NG ++E G+H L+ G+Y +++ Q E++ ++ E + S ++ D A++R+SS EK KI + F+R+++++ E ++ G ++A G + +L E+ VF + D + L+ L G I F QL + + +GEALT RLR + ++L+QE+A+FD+P + G LT LA S VK AAG +L I + AS W+L+L L F+P +A+ ++ K TG + S + +E N+RT+ L + F ++Y +L
Sbjct: 159 VRNADMIAAIHNGVVVETGSHAELMATDGVYRQLVTLQAFEEEGDEAAEDVDDFVRSMSINSDDTPSHLDRRVSLRASQRISSALRRTTSHGEKVKKIVEEEVEPAPFLRILKLNSPEWVFIAIGALSAMANGFLPLGFALCLGEILTVFTITDQ-KDKAKEEATFWALMFLAMGGISFFTQLFQNYMFALSGEALTVRLRRMSLKALLRQEIAFFDDPMHSTGALTTALATHTSDVKGAAGSRLGTIATGISTVIASAIYASINGWKLTLAVLAFVPFLAIGRALEIKGYTGDTGGQNDYIESGKVAVEAFENVRTIAILGREKTFFERYAQTL 492 HSP 3 Score: 232.261 bits (591), Expect = 8.890e-66 Identity = 116/199 (58.29%), Postives = 146/199 (73.37%), Query Frame = 1
Query: 1405 STLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
ST+I+L++R+YDP G V LDG DI++LNL W+R +IG+V QEP+LF ++A+NI YG + V + + AKMAN HDFI LP+GY TVVG++G LSGGQKQR+ IARAL P IL+LDEATSALDT+SE VVQ ALD+A+E T LVIAHRLST++NAD I I NGVVVE+G+H EL+ G Y L
Sbjct: 1 STVIKLIQRFYDPE------NGSVCLDGTDIRSLNLHWLRQRIGVVSQEPALFATTIAENIRYGQDG-VTQAEIEQAAKMANAHDFITKLPKGYETVVGEQGSQLSGGQKQRVAIARALVRNPRILILDEATSALDTESERVVQAALDKAREGRTTLVIAHRLSTVRNADMIAAIHNGVVVETGSHAELMATDGVYRQL 192
BLAST of Multidrug resistance protein 1 vs. Ensembl Nematostella
Match: EDO39130 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAY5]) HSP 1 Score: 252.292 bits (643), Expect = 3.728e-74 Identity = 134/294 (45.58%), Postives = 188/294 (63.95%), Query Frame = 1
Query: 1111 FSCFTMSTAALGRAL----SLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE-EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGS-NSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELI 1974
+ F + T +G ++ S + K A+ + Q DR A+ G+ P + L I+FKN++F YP+R N + L L + AG A+VG SG GKSTL LL R YDP G V + GHD+K+L+L W+R +G V Q+P LF+ S+A+NI YG+ +S+V + + A+ AN +FI S P GY+T+VG+RG LSGGQ+QRI IARA+ P ILLLDEATSALD++SE +VQEAL+R + T + IAHRLSTIKNAD IV+++ G +VESG++ +L+
Sbjct: 392 LTSFMLYTGFVGVSIAGLSSFYSELMKGIGASSRVWQLSDRKPAMSFTGGLQPSIDVLARGIQFKNVNFTYPSRPNARIFADLSLDMRAGSVTAVVGPSGSGKSTLGALLLRLYDPE------SGSVFVGGHDVKSLSLDWLRGAVGAVHQDPILFSCSIAENIAYGAASSEVSMDAIKDAARQANAANFIESFPNGYDTIVGERGQMLSGGQRQRIAIARAILKNPKILLLDEATSALDSESEHLVQEALERLMKGRTVITIAHRLSTIKNADNIVVLDGGSIVESGSYSQLM 679
BLAST of Multidrug resistance protein 1 vs. Ensembl Nematostella
Match: EDO41930 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S348]) HSP 1 Score: 249.595 bits (636), Expect = 3.655e-72 Identity = 145/362 (40.06%), Postives = 211/362 (58.29%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTA-ALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVV-PEEKLTGNIEFKNLHFRYPTRANVSVLR------------------GLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN 2019
G SG+ ++ +V + G +++G+ + + ++ F+ +T++ A A SL D +A A+ + + +DR+ I GV+ P K I F ++ F YP+R + VL+ L KIN G+TVALVG SG GKST+I L+ER+YDP G + + DI L+L+W R +I LV QEP LF ++A NI YG D E + + A+ AN HDFI + +GY T VG+RG LSGGQKQR+ IARAL P ILLLDEATSALD +SE V+EA+DRA N T LVIAHRLST+++A+ +++++ G +VE G H+ L+ G Y L ++ ++
Sbjct: 446 GAFSGVVMAVGQAAIVLVLWYGGKLVNEGEMN-VGILTAFALYTVNVAMAFAFLSSLYGDFMQAVGASFRMFELMDRVPKIKMEGGVILPSFK--EPIVFDDVRFSYPSREDTEVLKIEEAARQANAHDFITTFEALSFKINPGETVALVGPSGGGKSTVISLIERFYDPMT------GNIRIGDTDISLLDLAWYRKKIALVSQEPVLFATTIASNIAYGR--DASQEEIEEAARQANAHDFITTFEDGYKTQVGERGVKLSGGQKQRVAIARALLMDPEILLLDEATSALDAESEHFVKEAIDRAMVNRTVLVIAHRLSTVRSANLVLVMDKGKIVERGNHDSLLAKGGVYRKLVLRQLS 796 HSP 2 Score: 56.9954 bits (136), Expect = 1.879e-8 Identity = 31/113 (27.43%), Postives = 61/113 (53.98%), Query Frame = 2
Query: 494 LTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQR 832
+ +AW AG+ L R+R + ++++KQE+A+FD N G L RL+ + ++++A + +S+ + IV + SL F + +L+ + + IP + + G+ G R
Sbjct: 280 MIRAWLFTLAGQRLVARIRRELFNAIIKQEVAFFD--TNRTGELINRLSSDTQVIQNAVTVNVSMLLRYIVQIIGSLVFMFTLSAKLTGVLISVIPIVGVGAQKYGQFVQGLR 390
BLAST of Multidrug resistance protein 1 vs. Ensembl Nematostella
Match: EDO45926 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRD5]) HSP 1 Score: 228.024 bits (580), Expect = 2.978e-66 Identity = 127/273 (46.52%), Postives = 171/273 (62.64%), Query Frame = 1
Query: 1177 KARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIK-VAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHY 1992
+A AA K + IDR AI + V+P G IEFK++ F YPTR ++ VL + + GQ VALVG SG GKST I LLE Y+P G+VL+D +K L+ ++ N++ LV QEP LF S+ NI YG D ++ V+++AN H F+ +P+GY+T G++G LSGGQKQRI IARAL P ILLLDEATSALD +SE +VQ+A+ + + T L+IAHRLSTI+ AD I++I+ G V E GT+ LI G +
Sbjct: 296 EAVGAAEKVFKLIDREPAILNNGKVIPL-SCEGAIEFKDVSFSYPTRPDIPVLDNVSFMVEPGQVVALVGPSGGGKSTCINLLEHLYEPT------GGEVLIDAVPVKDLDHYYLHNKVSLVGQEPVLFARSIKKNIAYGVEDLADNPETVEHVSRLANAHSFVSGMPKGYDTETGEKGLQLSGGQKQRIAIARALIRNPKILLLDEATSALDAESEHLVQDAIYKNLQGHTVLIIAHRLSTIEKADLIIVIDKGQVAEIGTYSHLIAKDGLF 561
BLAST of Multidrug resistance protein 1 vs. Ensembl Medaka
Match: abcb4 (ATP binding cassette subfamily B member 1 [Source:NCBI gene;Acc:101171435]) HSP 1 Score: 312.768 bits (800), Expect = 3.374e-114 Identity = 164/339 (48.38%), Postives = 228/339 (67.26%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G + S +Y+ Y F GA + +G+ D+ + V S A+G A S A + KA+ +A + I+++ ID +++G P+ K GN+ FK++ F YP+R +V +L+GL+LK+ G+T+ALVG SGCGKST IQLLER+YD +G+V+LD DIK LN+ W+R+QIG+V QEP LF+ ++A+NI YG NS V E + AK ANIH FI LP+ YNT G +G LSGGQKQRI IARA+ P +LLLDEATSALDT+SE VVQ+ALD+A + TC+++AHRLSTI+NAD+I + + GVVVE GTH++L+ +G Y+ L
Sbjct: 945 GFTFSFSQSMIYFAYAGCFRFGAWLIVQGRMDVEGVFLVISAVLFGAMAVGEANSFAPNYAKAKMSAAHLMMLINKVPDIDNLSNEGETPD-KFNGNVIFKDVRFNYPSRPDVPILKGLNLKVKKGETLALVGSSGCGKSTTIQLLERFYDT------KEGKVVLDDVDIKQLNIHWLRSQIGIVSQEPVLFDCTLAENIAYGDNSRTVTMEEIEAAAKAANIHKFIEELPQRYNTQAGDKGTQLSGGQKQRIAIARAILRNPQVLLLDEATSALDTESEKVVQDALDQASKGRTCIIVAHRLSTIRNADRIAVFQGGVVVEQGTHQQLLAKKGVYHML 1276 HSP 2 Score: 120.553 bits (301), Expect = 3.374e-114 Identity = 102/357 (28.57%), Postives = 178/357 (49.86%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXX-----XXXXXXXSPESKTLTPTDAATRRLS--STANEEEFKLEKPSKIQMIK-------------DFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRT--LVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLY 988
+RNAD+I +NGK++E G H L+ QG+Y ++ Q +K E + E SP +K L+ + ++ + S+ N + K EK S + F R++ +++ E ++ G A I G + P +++++++ VFA PD + + R+ L+ + G + + +C K+GE LT +LR ++L+Q++ +FD+ +N G LT RLA +A+ V+ A G +L+ + NL + + F Y WEL+LL L +P IA+ G + ++ TG + L AG + E + NIRTV SL+ + F Y ++LK+ K S +
Sbjct: 595 IRNADVIAGFQNGKVVEVGTHSELMEKQGVYRMLVTMQTFQKADDGEEESEADEKSPLAKQLSDSTLFRKKSTRGSSVNSDTRKDEKKSFKKGKDKDKTNEDEDVPEVSFFRVLMLNKSEWPFIFLGTFCAIINGGIQPVFAVLFSKIIAVFAE----PDQEVVRERSQFFSLMFVTIGCVSFVTMFLQGFCFGKSGEVLTLKLRLGAFKAMLRQDLGWFDDSKNSVGALTTRLATDAAQVQGATGARLATVAQNFANLGTGIILAFIYGWELTLLVLAVVPIIAVAGAVGMQMLTGHAAEDKKELEKAG-----KIATEAIENIRTVASLTREAKFESLYQENLKVPYKNSQKKAH 942 HSP 3 Score: 297.745 bits (761), Expect = 4.549e-89 Identity = 153/331 (46.22%), Postives = 212/331 (64.05%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHK--GVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHY 1992
G +Y+ Y + F+ G+ + G+ + S++ VF + +G+ Q AR AA K ID+ ID++ G P+ + G+IEF N+HF YP+R +V +L + L + +GQT+ALVG SGCGKST IQLL+R+YDP +G V +DGHDI++LN+ ++R IG+V QEP LF ++++NI YG DV + + AK AN +DFI++LP + T+VG RG +SGGQKQRI IARAL P ILLLDEATSALD +SE +VQ ALD+ + T L++AHRLSTI+NAD I +NG VVE GTH EL+ +G Y
Sbjct: 303 GFTFLMIYFSYALAFWYGSTLILSGEYTIGSVLTVFFVVIIGVFTMGQTSPNIQTFASARGAAHKVYNIIDKEPIIDSYSEDGFKPD-FIKGDIEFSNIHFTYPSRPDVKILENMSLSVKSGQTMALVGSSGCGKSTTIQLLQRFYDPV------EGNVSIDGHDIRSLNVRYLREMIGVVSQEPILFATTISENIRYG-RPDVTQPEIEQAAKEANAYDFIMNLPNKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQSALDKVRLGRTTLIVAHRLSTIRNADVIAGFQNGKVVEVGTHSELMEKQGVY 625 HSP 4 Score: 51.6026 bits (122), Expect = 4.549e-89 Identity = 40/170 (23.53%), Postives = 86/170 (50.59%), Query Frame = 2
Query: 449 VLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK-LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
V ++ +L+ L + + AG + R+RT +++Q++ +FD N G L RL + ++ G ++ + I+++ + + IGF W+L+L+ L P + ++G + K L++ + + ++ EVL++IRTV + S Q+ ++Y +L+
Sbjct: 119 VYYSIMGAVVLVAAYLQVSLWTIAAGRQVK-RIRTLFFHKIMQQDIGWFD--INETGELNTRLTDDVYKIQEGIGDKVGMLIQSVSSFITAFVIGFTKGWKLTLVILAVSPALGISGALFSKVLTSFTSKEQSAYAKAGAVAEEVLSSIRTVFAFSGQNKEIERYHKNLQ 285
BLAST of Multidrug resistance protein 1 vs. Ensembl Medaka
Match: abcb11b (bile salt export pump [Source:NCBI gene;Acc:101163554]) HSP 1 Score: 296.59 bits (758), Expect = 2.931e-109 Identity = 163/333 (48.95%), Postives = 220/333 (66.07%), Query Frame = 1
Query: 1030 YVYCVVFFVGAI------FLDKGKTDMISLM-RVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPE-EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+ CVVF + +L K + SL+ RV S S ALGRA S D KA+ +A + Q +DR+ I + + GNIEF + F YPTR ++ VL GL + + GQT+A VG SGCGKST +QLLER+YDP G+VL+DGHD K +N+ ++R++IG+V QEP LF+ S+A+NI YG NS ++ + +I AK A +HDF+ +LPE YNT VG +G LS GQKQRI IARA+ P ILLLDEATSALDT+SE VQEALD+A+E TC+VIAHRLSTI+N+D I ++ G+++E G+H++L+ L+G YY L
Sbjct: 1029 FAQCVVFMTNSASYRFGGYLVKQEGLHFSLVFRVISAIVTSGTALGRASSYTPDYAKAKISAARFFQLLDRIPTISVYSDKGDKWNNFQGNIEFIDCKFTYPTRPDIQVLNGLTVSVKPGQTLAFVGSSGCGKSTSVQLLERFYDP------DHGKVLIDGHDSKHVNVPYLRSKIGIVSQEPILFDCSIAENIKYGDNSREISMDEVILAAKKAQLHDFVTALPEQYNTNVGSQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKTVQEALDKAREGRTCIVIAHRLSTIQNSDIIAVMSRGILIEQGSHDQLMGLKGAYYKL 1355 HSP 2 Score: 120.168 bits (300), Expect = 2.931e-109 Identity = 97/361 (26.87%), Postives = 173/361 (47.92%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQ----------------------------------------GLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIKD--FIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKY 940
++NAD+IV ++G+ +E+G H LL + G Y L + ++ + L PES D R S + +E+ K + + ++ R+++ + E Y++ G + A+I G V P SL+++++ F+++ P + + + + G + F Q+ + + K+GE LT RLR ++L QE+ +FD+ +N PG LT RLA +AS V+ A G Q+ + + ++ N+ ++ + FY++W+L+LL L F+P +AL+G Q K+ TG Q + TAG + E LNNIRT+ L + +F + Y
Sbjct: 652 IKNADVIVGFEHGRAVERGKHNELLERKGVYFTLVTLQSQGDKALNEKAQQMADSEKQEPERLNLSRAGSYRASLRASLHQRSRSQLSNLIPESSINVAGDLGLRTYSVSPSEKYDKATPEEEEEQVEPAPVARILKYNAPEWPYMLFGSLGAAINGGVNPVYSLLFSQILATFSVQD--PAAQRREIDGICVFFAMVGVVSFFTQMLQGYAFSKSGELLTRRLRRIGFHAMLGQEIGWFDDHRNSPGALTTRLATDASQVQGATGSQIGMIVNSLTNIGVAVLMSFYFSWKLTLLILCFLPFLALSGGFQAKMLTGFAKQDKQAMETAG-----RISGEALNNIRTIAGLGKEKNFVEMY 1005 HSP 3 Score: 258.455 bits (659), Expect = 3.793e-73 Identity = 153/343 (44.61%), Postives = 217/343 (63.27%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGA-IFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA-HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K + +G +G ++ Y + F+ G+ + +D + +L++VF ++ +LG+A + R AA +TIDR ID + E++ G+IEF N+ F YP+R V +L L +++ +G+T A VG SG GKST IQL++R+YDP +G V LDGHDI+ LN+ W+R+ IG+V+QEP LF ++A+NI YG V + +I AK AN ++FI+ LP+ ++T+VG+ GG +SGGQKQRI IARAL P ILLLD ATSALD +SE VVQEALD+ + T + IAHRLSTIKNAD IV E+G VE G H EL+ +G Y+ L
Sbjct: 350 KGLIMGFFTGYMWLIIFLCYALAFWYGSTLVVDTAEYTPGTLLQVFFGVLVAAMSLGQASPCLEAFAAGRGAATIIFETIDREPQIDCLSESGYKLERVKGDIEFHNVTFHYPSRPEVKILDQLSVQVKSGETTAFVGPSGAGKSTAIQLIQRFYDPL------EGMVTLDGHDIRGLNIQWLRSLIGIVEQEPVLFATTIAENIRYG-RPGVSMDDIINAAKEANAYNFIMDLPQKFDTLVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMATSALDNESEAVVQEALDKVRMGRTTISIAHRLSTIKNADVIVGFEHGRAVERGKHNELLERKGVYFTL 685
BLAST of Multidrug resistance protein 1 vs. Ensembl Medaka
Match: ABCB4 (multidrug resistance protein 1-like [Source:NCBI gene;Acc:105357817]) HSP 1 Score: 310.457 bits (794), Expect = 5.709e-101 Identity = 164/339 (48.38%), Postives = 228/339 (67.26%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAID--AHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNS-DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G + S +Y+ Y F GA + +G+ D+ + V S A+G A S A + KA+ +A + I+++ ID +++G P+ K GN+ FK++ F YP+R +V +L+GL+LK+ G+T+ALVG SGCGKST IQLLER+YD +G+V+LD DIK LN+ W+R+QIG+V QEP LF+ ++A+NI YG NS V E + AK ANIH FI LP+ YNT G +G LSGGQKQRI IARA+ P +LLLDEATSALDT+SE VVQ+ALD+A + TC+++AHRLSTI+NAD+I + + GVVVE GTH++L+ +G Y+ L
Sbjct: 166 GFTFSFSQSMIYFAYAGCFRFGAWLIVQGRMDVEGVFLVISAVLFGAMAVGEANSFAPNYAKAKMSAAHLMMLINKVPDIDNLSNEGETPD-KFNGNVIFKDVRFNYPSRPDVPILKGLNLKVKKGETLALVGSSGCGKSTTIQLLERFYDT------KEGKVVLDDVDIKQLNIHWLRSQIGIVSQEPVLFDCTLAENIAYGDNSRTVTMEEIEAAAKAANIHKFIEELPQRYNTQAGDKGTQLSGGQKQRIAIARAILRNPQVLLLDEATSALDTESEKVVQDALDQASKGRTCIIVAHRLSTIRNADRIAVFQGGVVVEQGTHQQLLAKKGVYHML 497 HSP 2 Score: 78.5666 bits (192), Expect = 5.709e-101 Identity = 48/143 (33.57%), Postives = 76/143 (53.15%), Query Frame = 2
Query: 578 QEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG------QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLY 988
Q++ +FD+ +N G LT RLA +A+ V+ A G +L+ + NL + + F Y WEL+LL L +P IA+ G + ++ TG + L AG + E + NIRTV SL+ + F Y ++LK+ K S +
Sbjct: 26 QDLGWFDDSKNSVGALTTRLATDAAQVQGATGARLATVAQNFANLGTGIILAFIYGWELTLLVLAVVPIIAVAGAVGMQMLTGHAAEDKKELEKAG-----KIATEAIENIRTVASLTREAKFESLYQENLKVPYKNSQKKAH 163
BLAST of Multidrug resistance protein 1 vs. Ensembl Medaka
Match: abcb4 (ATP binding cassette subfamily B member 1 [Source:NCBI gene;Acc:101171435]) HSP 1 Score: 298.13 bits (762), Expect = 1.507e-91 Identity = 153/331 (46.22%), Postives = 212/331 (64.05%), Query Frame = 1
Query: 1006 GLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHK--GVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHY 1992
G +Y+ Y + F+ G+ + G+ + S++ VF + +G+ Q AR AA K ID+ ID++ G P+ + G+IEF N+HF YP+R +V +L + L + +GQT+ALVG SGCGKST IQLL+R+YDP +G V +DGHDI++LN+ ++R IG+V QEP LF ++++NI YG DV + + AK AN +DFI++LP + T+VG RG +SGGQKQRI IARAL P ILLLDEATSALD +SE +VQ ALD+ + T L++AHRLSTI+NAD I +NG VVE GTH EL+ +G Y
Sbjct: 280 GFTFLMIYFSYALAFWYGSTLILSGEYTIGSVLTVFFVVIIGVFTMGQTSPNIQTFASARGAAHKVYNIIDKEPIIDSYSEDGFKPD-FIKGDIEFSNIHFTYPSRPDVKILENMSLSVKSGQTMALVGSSGCGKSTTIQLLQRFYDPV------EGNVSIDGHDIRSLNVRYLREMIGVVSQEPILFATTISENIRYG-RPDVTQPEIEQAAKEANAYDFIMNLPNKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAESETIVQSALDKVRLGRTTLIVAHRLSTIRNADVIAGFQNGKVVEVGTHSELMEKQGVY 602 HSP 2 Score: 51.2174 bits (121), Expect = 3.270e-6 Identity = 40/170 (23.53%), Postives = 86/170 (50.59%), Query Frame = 2
Query: 449 VLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGK-LSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLK 955
V ++ +L+ L + + AG + R+RT +++Q++ +FD N G L RL + ++ G ++ + I+++ + + IGF W+L+L+ L P + ++G + K L++ + + ++ EVL++IRTV + S Q+ ++Y +L+
Sbjct: 96 VYYSIMGAVVLVAAYLQVSLWTIAAGRQVK-RIRTLFFHKIMQQDIGWFD--INETGELNTRLTDDVYKIQEGIGDKVGMLIQSVSSFITAFVIGFTKGWKLTLVILAVSPALGISGALFSKVLTSFTSKEQSAYAKAGAVAEEVLSSIRTVFAFSGQNKEIERYHKNLQ 262
BLAST of Multidrug resistance protein 1 vs. Ensembl Medaka
Match: abcb11a (ATP binding cassette subfamily B member 11 [Source:NCBI gene;Acc:101157171]) HSP 1 Score: 303.523 bits (776), Expect = 6.736e-89 Identity = 164/348 (47.13%), Postives = 225/348 (64.66%), Query Frame = 1
Query: 961 WKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSD-VDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
+K K + G GL ++ Y F G + + + RV S +S ALGRA S D KA+ AA + + +DR+ I +H E G +EF N F YPTR + VL+GL + + GQT+ALVG SGCGKST +QLLER+YDP +G+VL+DG ++++ ++R+QIG+V QEP LF+ S+A+NI YG NS ++ E +++ AK AN+HDF+++LP+ Y+T VG +G LS GQKQRI IARA+ P ILLLDEATSALDT+SE +VQ ALD A++ TC+VIAHRLSTI+NAD I ++ +GVV+E GTH+EL+ RG YY L
Sbjct: 958 YKSAKKRANIYGLCFGLTQCVIFMAYAASFRFGGYLVRAEGLQYMLVFRVISAVVISGTALGRASSFTPDYAKAKTAAAQFFKLLDRVPKI-SHTDGEKWENFKGEVEFLNCKFTYPTRPDTQVLKGLVVSVKPGQTLALVGSSGCGKSTGVQLLERFYDP------DEGKVLIDGRPSYSVSVPFLRSQIGIVSQEPVLFDCSIAENIQYGDNSHRINMEEIVEAAKTANLHDFVMTLPDKYDTQVGAQGSQLSRGQKQRIAIARAIIRNPKILLLDEATSALDTESEQIVQSALDEARKGRTCIVIAHRLSTIQNADIIAVMSHGVVIEQGTHDELMAKRGAYYKL 1298 HSP 2 Score: 254.603 bits (649), Expect = 2.728e-75 Identity = 148/344 (43.02%), Postives = 218/344 (63.37%), Query Frame = 1
Query: 991 LGCVSGLAVSALYYVYCVVFFVGA-IFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDA-HKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL-NVQN 2013
+G G ++ Y + F+ G+ + +D + +L++VF ++ LG+A + R AA+ +TIDR ID + +K+ G+IEF N+ F YP+R ++ +L L+L I AG+T A VG SG GK++ +QL++R+YDP +G V LDGHD+++LN+ W+R+ IG+V+QEP LF ++A+NI YG V E +I+ + AN + FI+ LP+ ++T+VG+ GG +SGGQKQRI IARAL KP ILLLD ATSALD +SE VQEAL++ T + +AHRLSTI++AD IV E+G VE GTH EL+ +G Y+ L +QN
Sbjct: 305 IGVFQGYLWCIIFLCYALAFWYGSKLVIDSKELSPGNLIQVFFGVLIAATNLGQAAPCLEAFASGRAAAKTVFETIDREPEIDCLSEDGYKLDKIKGDIEFHNVTFYYPSRPDIKILDDLNLHIKAGETTAFVGPSGSGKTSAVQLIQRFYDP------KEGMVTLDGHDLRSLNIQWLRSLIGIVEQEPVLFATTIAENIRYG-RPGVTMEDIIQATREANAYHFIMDLPQKFDTLVGEGGGQMSGGQKQRIAIARALVRKPRILLLDMATSALDNESEATVQEALNKVHTERTTISVAHRLSTIRSADVIVGFEHGRAVEKGTHRELLERKGVYFTLVTLQN 641 HSP 3 Score: 48.9062 bits (115), Expect = 2.728e-75 Identity = 40/145 (27.59%), Postives = 73/145 (50.34%), Query Frame = 2
Query: 515 VKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIAL-TGIMQGKLS--TGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKY 940
V A T R+R V++ E+ +FD N G L R++ + + + +A Q+S+FIE I +GF W+L+L+ + P I + G+M ++ TG+ L + ++ EVL++IRTV + ++ ++Y
Sbjct: 147 VSAAARQTQRIRKTYFRRVMQMEIGWFD--CNSVGELNTRISDDINKISNAIADQVSIFIERISTFIFGFMVGFIGGWKLTLVVVAVSPLIGMGAGLMAMAVARLTGRELKA--YAKAGAVADEVLSSIRTVAAFGGEEKEAERY 287 HSP 4 Score: 131.724 bits (330), Expect = 3.635e-31 Identity = 76/211 (36.02%), Postives = 121/211 (57.35%), Query Frame = 2
Query: 371 IYAELYNVFALKFTFPDLMISKGRT--LVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTG-QRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGK--KSNPNLY 988
IYA L++ F+ PDL + + + LL + I F Q + + K+GE LT RLR ++LKQE+ +FD+P+N PG LT RLA +AS+V+ A G Q+ + I ++ ++ AS I FY++W+L+L+ L F+P I L+G+ Q K+ TG + ++ + E L NIRTV L+ + F + + + L+L K K N+Y
Sbjct: 758 IYAVLFSQILGTFSIPDLDEQRRQINGICLLFCVVAVISFFSQFIQGFSFAKSGELLTRRLRKVGFQAMLKQEIGWFDDPENSPGALTTRLATDASMVQGATGSQIGMIINSLTSIGASFIIAFYFSWKLTLVILGFLPLIGLSGVFQAKMLTGFAKEDKKAMEAAGRVSSEALGNIRTVAGLTKERSFVESFEEKLELPYKSAKKRANIY 968
BLAST of Multidrug resistance protein 1 vs. Planmine SMEST
Match: SMESG000027392.1 (SMESG000027392.1) HSP 1 Score: 731.865 bits (1888), Expect = 0.000e+0 Identity = 352/352 (100.00%), Postives = 352/352 (100.00%), Query Frame = 1
Query: 964 KKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN 2019
KKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN
Sbjct: 907 KKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN 1258 HSP 2 Score: 561.607 bits (1446), Expect = 0.000e+0 Identity = 324/336 (96.43%), Postives = 326/336 (97.02%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFWAALAA 1009
VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWEMLEHQMKEKKEEKDQELSPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLIAGVIAASIVGAVFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCL KAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGSVSSSSLVLEVLNNIRTVNSLSLQDHFGDKYFDSLKLDGKK L F ++
Sbjct: 586 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWEMLEHQMKEKKEEKDQELSPESKTLTPTDAATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLIAGVIAASIVGAVFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLGKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGSVSSSSLVLEVLNNIRTVNSLSLQDHFGDKYFDSLKLDGKKIKSKLVFLGCVSG 921 HSP 3 Score: 271.552 bits (693), Expect = 6.987e-78 Identity = 139/339 (41.00%), Postives = 218/339 (64.31%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHK-GVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDR--AQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G SG+ ++ V +V+++G +F+ +G D +++++F + + ALG A+ + ++ A+ AA Q IDR+ I K GV+PE G+IEFKN+ F YPTR V +L+ + + G+TVA +G SG GKST+I LL+R+YDP G++ G D+K ++L+W R+ IG+V+QEP LF+ S+ +NI G ++ E ++K + +N ++FI+ + +NT +G RG SGGQKQRI IA AL P +LLLDEATSALD SE +VQ+ LD+ A+ T +++AHRL T++NAD IV+++NG ++E G HE L+N +G Y+++
Sbjct: 289 GLGSGVIGFTIFTVGSLVYYMGLLFIYEGSYDPGTVIQIFLTIVIGSIALGNAVPMLENFITAKAAAYPLFQVIDRVPQISHKKHGVIPES-FYGDIEFKNVDFEYPTRPGVPILQNFNFTLPYGKTVAFIGPSGSGKSTIIHLLQRFYDPLA------GEISFSGTDLKDIDLTWYRSHIGVVQQEPPLFSGSIQENIQLGKMDAIN-EEIVKSTQDSNAYEFIMKTKQKFNTPLGDRGAGFSGGQKQRIAIAMALVRNPQLLLLDEATSALDNISEKLVQKTLDKTIAEGKRTVVMVAHRLQTVRNADIIVVMKNGKIIEQGNHETLLNHQGLYWEM 619 HSP 4 Score: 50.0618 bits (118), Expect = 6.590e-6 Identity = 42/155 (27.10%), Postives = 73/155 (47.10%), Query Frame = 2
Query: 353 FPCASLIYAELYNVFA----LKFTFPDLM---ISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALT 796
FP LI+ ++ N+ L TF + M + K L I GFI + L A + + RLR+ +++L+QE+ +FD+ Q G L +L + ++S +L+ FI+ I + + + F W+LS + + IP +A T
Sbjct: 76 FPLNVLIFRDVVNLLVSPRDLTMTFSERMRPSVIKFAILSSCTFISGFIQMV-----TISLTAARQ--SRRLRSNYFNALLRQEICWFDKQQT--GQLVTKLTDDVESIESGISDKLAAFIQQISSFVGCIILAFTTGWKLSFIGSMSIPIMATT 221
BLAST of Multidrug resistance protein 1 vs. Planmine SMEST
Match: SMESG000027396.1 (SMESG000027396.1) HSP 1 Score: 513.072 bits (1320), Expect = 0.000e+0 Identity = 241/349 (69.05%), Postives = 293/349 (83.95%), Query Frame = 1
Query: 973 KSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN 2019
K ++ G ++G++VS+LYY YCVVF+VGAI +D+G MI LMRVFSCFTMS +ALGRAL+ + DT+KAR AARKTL TIDR++ I+ + G++PE+KLTG IEFK+++FRYPTR NVSVLR L+L IN G++VALVGHSGCGKSTL+QLLERYYDP S + G G+VLLD DIK LNLSWVR+QIG+VKQEPSLFN+S+ DNI YGS + + E +I KMANIHDFI LPE YNT+VGQRGGHLSGGQKQRICIARALYNKP ILLLDEATSALDT+SEI+VQEALD+AQ ++T LVIAHRLSTIKN+DKI +IE G V+E G HE L+ L+G+YY LN+++VN
Sbjct: 423 KYQIFLYGLMNGISVSSLYYAYCVVFYVGAILIDQGSCTMIRLMRVFSCFTMSASALGRALAQSTDTDKARIAARKTLSTIDRVSKINVNSGIIPEKKLTGKIEFKDIYFRYPTRLNVSVLRVLNLTINPGESVALVGHSGCGKSTLLQLLERYYDPIPSSSRGLGKVLLDDQDIKGLNLSWVRSQIGMVKQEPSLFNLSILDNITYGSKNPISMEEVIIATKMANIHDFIEDLPEKYNTLVGQRGGHLSGGQKQRICIARALYNKPAILLLDEATSALDTESEILVQEALDKAQASSTNLVIAHRLSTIKNSDKIAVIEYGKVIELGNHERLMELKGNYYGLNMEHVN 771 HSP 2 Score: 284.648 bits (727), Expect = 0.000e+0 Identity = 183/332 (55.12%), Postives = 234/332 (70.48%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTDAAT--RRLS-STANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKGRTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLY 988
VRNADIIVVMKNGKI+EQGNH +LL GLYWEML Q +K+E E L T+ A R+ S + A EE K K Q +KDF L+RI+ E YLI G+I++ IVG FPCASLIY++++ VF+ K + M+S+G LHL+P L Q+ K L KAGE LT +LR+ MM+S+L+QEMA+FDEP+NLPG+LTARLA+EASLVK AAGIQLS+++EA N+ A+L IGF ++W+LSLLF IFIP I LTGI+QG+L+TGQR + G VSSS+L++EVLNNIRTVNSL LQ+ F +K ++SLK KK LY
Sbjct: 105 VRNADIIVVMKNGKIVEQGNHSSLLAQHGLYWEMLGTQKVPEKDE-----EEEFVPLIKTELAESLRKFSLNQAIVEEIK--KSETGQFLKDFSHLLRINGSEKYYLIFGMISSIIVGITFPCASLIYSQMFQVFSYKLSDNARMLSEGFLFAGLHLLPAATLFVMQIIKNIFLGKAGEILTMKLRSKMMASMLQQEMAWFDEPKNLPGILTARLAMEASLVKGAAGIQLSIYMEAFSNIVAALIIGFIFSWQLSLLFFIFIPFITLTGIIQGRLATGQRATGGGEVSSSALIMEVLNNIRTVNSLGLQNFFQEKLYNSLKSTTKKYQIFLY 429 HSP 3 Score: 125.946 bits (315), Expect = 9.254e-30 Identity = 62/134 (46.27%), Postives = 91/134 (67.91%), Query Frame = 1
Query: 1606 DVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDR--AQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
D + ++K + +N +DFI++ E ++T +G RG SGGQKQRI IA AL P +LLLDEATSALD +SE +VQ+ LD A+ T +++AHRL T++NAD IV+++NG +VE G H L+ G Y+++
Sbjct: 5 DATEDEIVKSTQDSNAYDFIMATKETFDTKLGDRGTGFSGGQKQRIAIATALIRDPQMLLLDEATSALDNKSEKLVQKTLDTTIAEGKRTIVMVAHRLQTVRNADIIVVMKNGKIVEQGNHSSLLAQHGLYWEM 138
BLAST of Multidrug resistance protein 1 vs. Planmine SMEST
Match: SMESG000027393.1 (SMESG000027393.1) HSP 1 Score: 513.072 bits (1320), Expect = 8.520e-177 Identity = 252/391 (64.45%), Postives = 308/391 (78.77%), Query Frame = 1
Query: 847 IRFVEFVGLGSFKQYQNCQFFKSARSFWRQIFR*P*TGWKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN 2019
IR V +GL +F Q + F+KS + + K ++ G +SG++VSALYY YCVVF+VGAI +D+G MI LMRVFSCFTMS +ALGRAL+ + DT+KAR AARKTL TIDR++ I+ + G++PE+KLTG IEFK+++FRYPTR NVSVLR L+L IN G++VALVGHSGCGKSTL+QLLERYYDP S + G G+VLLD DIK LNLSWVR+QIG+VKQEPSLFN+S+ DNI YGS + + E +I KMANIHDFI LPE YNT+VGQRGGHLSGGQKQRICIARALYNKP ILLLDEATSALDT+SEI+VQEALD+AQ ++T LVIAHRLSTIKN+DKI +IE G V+E G HE L+ L+G+YY LN+++ N
Sbjct: 112 IRTVNSLGLQNFFQEK---FYKSLKVSTK-------------KYEIFLYGYISGISVSALYYAYCVVFYVGAILIDQGSCTMIRLMRVFSCFTMSASALGRALAQSTDTDKARIAARKTLSTIDRVSKINVNSGIIPEKKLTGKIEFKDIYFRYPTRLNVSVLRVLNLTINPGESVALVGHSGCGKSTLLQLLERYYDPIPSSSRGLGKVLLDDQDIKGLNLSWVRSQIGMVKQEPSLFNLSILDNITYGSKNTIIMEEVIIATKMANIHDFIEDLPEKYNTLVGQRGGHLSGGQKQRICIARALYNKPAILLLDEATSALDTESEILVQEALDKAQASSTNLVIAHRLSTIKNSDKIAVIEYGKVIELGNHERLMELKGNYYGLNMEDFN 486 HSP 2 Score: 176.792 bits (447), Expect = 5.083e-48 Identity = 94/146 (64.38%), Postives = 122/146 (83.56%), Query Frame = 2
Query: 557 MMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFW 994
MM+S+L+QEMA+FDEP+NLPG+LTARLA+EASLVK AAGIQLS+++EA N+ A+L IGF ++W+LSLLF IFIP I LTGI+QG+L+TGQR + G VSSS+L++EVLNNIRTVNSL LQ+ F +K++ SLK+ KK LY +
Sbjct: 1 MMASMLQQEMAWFDEPENLPGILTARLAMEASLVKGAAGIQLSIYMEAFSNVVAALIIGFIFSWQLSLLFFIFIPFITLTGIIQGRLATGQRATGGGEVSSSALIMEVLNNIRTVNSLGLQNFFQEKFYKSLKVSTKKYEIFLYGY 146
BLAST of Multidrug resistance protein 1 vs. Planmine SMEST
Match: SMESG000027393.1 (SMESG000027393.1) HSP 1 Score: 512.686 bits (1319), Expect = 1.104e-176 Identity = 252/391 (64.45%), Postives = 308/391 (78.77%), Query Frame = 1
Query: 847 IRFVEFVGLGSFKQYQNCQFFKSARSFWRQIFR*P*TGWKKIKSKLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEEKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDLNVQNVN 2019
IR V +GL +F Q + F+KS + + K ++ G +SG++VSALYY YCVVF+VGAI +D+G MI LMRVFSCFTMS +ALGRAL+ + DT+KAR AARKTL TIDR++ I+ + G++PE+KLTG IEFK+++FRYPTR NVSVLR L+L IN G++VALVGHSGCGKSTL+QLLERYYDP S + G G+VLLD DIK LNLSWVR+QIG+VKQEPSLFN+S+ DNI YGS + + E +I KMANIHDFI LPE YNT+VGQRGGHLSGGQKQRICIARALYNKP ILLLDEATSALDT+SEI+VQEALD+AQ ++T LVIAHRLSTIKN+DKI +IE G V+E G HE L+ L+G+YY LN+++ N
Sbjct: 111 IRTVNSLGLQNFFQEK---FYKSLKVSTK-------------KYEIFLYGYISGISVSALYYAYCVVFYVGAILIDQGSCTMIRLMRVFSCFTMSASALGRALAQSTDTDKARIAARKTLSTIDRVSKINVNSGIIPEKKLTGKIEFKDIYFRYPTRLNVSVLRVLNLTINPGESVALVGHSGCGKSTLLQLLERYYDPIPSSSRGLGKVLLDDQDIKGLNLSWVRSQIGMVKQEPSLFNLSILDNITYGSKNTIIMEEVIIATKMANIHDFIEDLPEKYNTLVGQRGGHLSGGQKQRICIARALYNKPAILLLDEATSALDTESEILVQEALDKAQASSTNLVIAHRLSTIKNSDKIAVIEYGKVIELGNHERLMELKGNYYGLNMEDFN 485 HSP 2 Score: 174.481 bits (441), Expect = 3.212e-47 Identity = 93/145 (64.14%), Postives = 121/145 (83.45%), Query Frame = 2
Query: 560 MSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXXXXXXXXXNNIRTVNSLSLQDHFGDKYFDSLKLDGKKSNPNLYFW 994
M+S+L+QEMA+FDEP+NLPG+LTARLA+EASLVK AAGIQLS+++EA N+ A+L IGF ++W+LSLLF IFIP I LTGI+QG+L+TGQR + G VSSS+L++EVLNNIRTVNSL LQ+ F +K++ SLK+ KK LY +
Sbjct: 1 MASMLQQEMAWFDEPENLPGILTARLAMEASLVKGAAGIQLSIYMEAFSNVVAALIIGFIFSWQLSLLFFIFIPFITLTGIIQGRLATGQRATGGGEVSSSALIMEVLNNIRTVNSLGLQNFFQEKFYKSLKVSTKKYEIFLYGY 145
BLAST of Multidrug resistance protein 1 vs. Planmine SMEST
Match: SMESG000004996.1 (SMESG000004996.1) HSP 1 Score: 291.582 bits (745), Expect = 3.435e-105 Identity = 149/340 (43.82%), Postives = 221/340 (65.00%), Query Frame = 1
Query: 994 GCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHK--GVVPE-EKLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDV-DYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
G + GL +A++ Y F + L + M ++ F LG+++++A + K + AA + +DR+ I++ GVV + E ++G+I+ +N+ F YP R N+ +L + IN+ QT+ALVG SGCGKST+I LL+R+YD G +L+D + IK +N+ +R +V QEP+LF+ S+ +NI YG ++ + + +I AK +NIHDFI++LP+ Y T VG++G + SGGQKQRI IARAL P ILLLDEATSALDT+SE +VQ+ALD+AQE TC+VIAHRLSTI+NADKI++ ++G + ESGTH EL++ G Y +
Sbjct: 978 GFLYGLTQAAIFCAYAATFMLAGYLLLYNMSKMTNVFISFGALIFGAMNLGKSMAMAPNFGKGKIAAAHMFELLDRVPPINSFSTDGVVLDVENMSGDIKIENVKFSYPLRPNIIILNDVSFNINSNQTIALVGPSGCGKSTIIGLLQRFYDTL------NGNILIDNNKIKDINIQNLRQLFSIVSQEPTLFSYSIRENIAYGDSAKIFTDDQIIAAAKASNIHDFIVNLPDQYETKVGEKGSNFSGGQKQRIAIARALLRNPRILLLDEATSALDTESEKIVQDALDKAQEGRTCVVIAHRLSTIQNADKILVFKDGKIAESGTHFELLSKNGIYSQM 1311 HSP 2 Score: 111.309 bits (277), Expect = 3.435e-105 Identity = 99/334 (29.64%), Postives = 170/334 (50.90%), Query Frame = 2
Query: 2 VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWXXXXXXXXXXXXXXXXXXSPESKTLTPTD------AATRRLSSTANEEEFKLEKPSKIQMIKDFIRLMRISRMEGGYLXXXXXXXXXXXXXFPCASLIYAELYNVFALKFTFPDLMISKG--RTLVLLHLIPGFILLFGQLTKAWCLVKAGEALTTRLRTFMMSSVLKQEMAYFDEPQNLPGVLTARLAVEASLVKSAAGIQLSVFIEAIVNLSASLFIGFYYNWELSLLFLIFIPCIALTGIMQGKLSTGQRLSTAGXXXXX-XXXXXXXNNIRTVNSLSLQDHFGDKYFDSL-KLDGKKS 973
VRNA +I +K+GK+ EQG H L+ GLY + ++++ + + + D + T+RLS EE + K + F ++M ++ E Y+ G ++A GAV P S+++ L A P++ RT V+ + + + +GE LT R R+ ++LKQ++A+FDEP N G LT RL+ EA+ ++ +G L I AI ++ A++ I F + W++SL+ L F+P I + GI+Q ++ G S G++ S + +E + NIRTV++L+ + F Y +++ KLDG+ S
Sbjct: 647 VRNAHVIFGIKDGKVQEQGTHAELMALNGLY-----KDLVDRQKIDHGQKGEKEEIYVNVDEEIIKESPTKRLSVAKIEEVIEENKEIVKKSSAGFFKVMGLNAPEKCYIFLGCVSAIFNGAVQPSFSILFGFLLPAMA----NPNIEQQSADIRTYVIALAGIAVVAFVSSVLQNVGFGNSGEQLTKRCRSITFEAMLKQDIAWFDEPSNNIGALTTRLSDEATQIRGVSGESLGAVITAICSMGAAVAISFGFCWQISLVVLAFVPIIFVGGILQIRIMQGFSNSDKGALEESGKIAVECIENIRTVSNLTREHTFIQHYKEAIKKLDGEVS 971 HSP 3 Score: 285.419 bits (729), Expect = 1.342e-82 Identity = 161/348 (46.26%), Postives = 215/348 (61.78%), Query Frame = 1
Query: 979 KLVFLGCVSGLAVSALYYVYCVVFFVGAIFLDKGKTDMISLMRV--FSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAHKGVVPEE-----KLTGNIEFKNLHFRYPTRANVSVLRGLDLKINAGQTVALVGHSGCGKSTLIQLLERYYDPWVSKNYGQGQVLLDGHDIKALNLSWVRNQIGLVKQEPSLFNISVADNIIYGSNSDVDYEHMIKVAKMANIHDFILSLPEGYNTVVGQRGGHLSGGQKQRICIARALYNKPPILLLDEATSALDTQSEIVVQEALDRAQENTTCLVIAHRLSTIKNADKIVIIENGVVVESGTHEELINLRGHYYDL 2001
K + G + GL + ++ Y + F+ GA + +G ++ M + FSC M+T +G+A +AR AA + + IDR+ ID + EE G I FK + F YPTR + +L GL L I GQTVALVG SGCGKS+LIQL++R+YD +G+VL+D +IK LN+ W+R QIG+V QEP LF S+ +NI YG DV E + + MAN FI +LP +T+VG RG LSGGQKQRI IARAL P ILLLDEATSALD++SE +VQ+ALD+ E T +++AHRLST++NA I I++G V E GTH EL+ L G Y DL
Sbjct: 345 KSILTGTLLGLVMGLMFGSYALGFWYGASLIREGNGFLVGDMLIVFFSCL-MATTGIGQATPHMGSFNEARSAAAEIFEIIDRVPEIDK----MNEEGDKLNDFQGKITFKYVKFTYPTRTDCPILTGLSLSIQPGQTVALVGASGCGKSSLIQLMQRFYDS------NEGEVLIDDTNIKDLNVMWLREQIGVVSQEPVLFGCSIKENIRYG-RMDVTDEEIDQALVMANAKTFINALPNKLDTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDSESEKIVQDALDKVVEGRTTIIVAHRLSTVRNAHVIFGIKDGKVQEQGTHAELMALNGLYKDL 680 The following BLAST results are available for this feature:
BLAST of Multidrug resistance protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Multidrug resistance protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029674 ID=SMED30029674|Name=Multidrug resistance protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=2045bpback to top protein sequence of SMED30029674-orf-1 >SMED30029674-orf-1 ID=SMED30029674-orf-1|Name=SMED30029674-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=337bp VRNADIIVVMKNGKIIEQGNHETLLNHQGLYWEMLEHQMKEKKEEKDQELback to top protein sequence of SMED30029674-orf-2 >SMED30029674-orf-2 ID=SMED30029674-orf-2|Name=SMED30029674-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=311bp MISLMRVFSCFTMSTAALGRALSLAQDTEKARKAARKTLQTIDRLTAIDAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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