DNA mismatch repair protein

Overview
NameDNA mismatch repair protein
Smed IDSMED30029667
Length (bp)754
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DNA mismatch repair protein (SMED30029667) t-SNE clustered cells

Violin plots show distribution of expression levels for DNA mismatch repair protein (SMED30029667) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DNA mismatch repair protein (SMED30029667) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DNA mismatch repair protein (SMED30029667) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30029667

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
prepharyngeal regionSMED30029667h1SMcG0012173 dd_Smed_v6_25712_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Human
Match: MLH3 (mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128])

HSP 1 Score: 63.5438 bits (153), Expect = 2.813e-12
Identity = 29/49 (59.18%), Postives = 36/49 (73.47%), Query Frame = 3 
Query:  519 ILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIA 665
            +L S+AC  AIKF D L+  E  RLI  L+ C LPFQCAHGRPS++P+A
Sbjct:   27 VLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLA 75
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Human
Match: MLH3 (mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128])

HSP 1 Score: 64.3142 bits (155), Expect = 2.846e-11
Identity = 29/49 (59.18%), Postives = 36/49 (73.47%), Query Frame = 3 
Query:  519 ILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIA 665
            +L S+AC  AIKF D L+  E  RLI  L+ C LPFQCAHGRPS++P+A
Sbjct:  380 VLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLA 428
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Human
Match: MLH3 (mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128])

HSP 1 Score: 64.3142 bits (155), Expect = 3.614e-11
Identity = 29/49 (59.18%), Postives = 36/49 (73.47%), Query Frame = 3 
Query:  519 ILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIA 665
            +L S+AC  AIKF D L+  E  RLI  L+ C LPFQCAHGRPS++P+A
Sbjct: 1178 VLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLA 1226
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Human
Match: MLH3 (mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128])

HSP 1 Score: 64.3142 bits (155), Expect = 3.677e-11
Identity = 29/49 (59.18%), Postives = 36/49 (73.47%), Query Frame = 3 
Query:  519 ILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIA 665
            +L S+AC  AIKF D L+  E  RLI  L+ C LPFQCAHGRPS++P+A
Sbjct: 1356 VLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLA 1404
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Human
Match: MLH3 (mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128])

HSP 1 Score: 64.3142 bits (155), Expect = 3.677e-11
Identity = 29/49 (59.18%), Postives = 36/49 (73.47%), Query Frame = 3 
Query:  519 ILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIA 665
            +L S+AC  AIKF D L+  E  RLI  L+ C LPFQCAHGRPS++P+A
Sbjct: 1356 VLASQACHGAIKFNDGLSLQESCRLIEALSSCQLPFQCAHGRPSMLPLA 1404
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Celegans
Match: pms-2 (PMS (Post Meiotic Segregation) family [Source:UniProtKB/TrEMBL;Acc:G5EFG5])

HSP 1 Score: 54.299 bits (129), Expect = 2.587e-8
Identity = 34/97 (35.05%), Postives = 54/97 (55.67%), Query Frame = 3 
Query:  387 CYLTKAPLLLLKNEKLTVPELKVVDIISSILNDPKKDKENIMI-DILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLP 674
             +LT  P LL  N++LT  +L+  +I++ +   P +    + I  I  SKAC  ++  G  L + EM ++I  LAK   P+ C HGRP++  +A LP
Sbjct:  707 TFLTARPELL--NQQLTNSDLE--EILAVVSQYPNQMYRPVRIRKIFASKACRKSVMIGKPLNQREMTQIIRHLAKLDQPWNCPHGRPTIRHLASLP 799
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Zebrafish
Match: mlh3 (mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060810-45])

HSP 1 Score: 56.9954 bits (136), Expect = 7.100e-9
Identity = 28/52 (53.85%), Postives = 40/52 (76.92%), Query Frame = 3 
Query:  516 DILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALL 671
            ++L S+AC  AIKF D+L ++E   L++ L+ C LPFQCAHGRPS++P+A L
Sbjct: 1082 NVLASQACHGAIKFNDVLNKEECCSLVSSLSSCRLPFQCAHGRPSIVPLADL 1133
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Xenopus
Match: mlh3 (mutL homolog 3 [Source:NCBI gene;Acc:100493832])

HSP 1 Score: 65.0846 bits (157), Expect = 1.744e-11
Identity = 27/53 (50.94%), Postives = 41/53 (77.36%), Query Frame = 3 
Query:  507 IMIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIA 665
             ++ +L S+AC  AIKF D L+ D+ + L+  L++CSLPFQCAHGRP+++P+A
Sbjct: 1160 TVLKVLASQACHGAIKFNDQLSLDDCKHLMQCLSRCSLPFQCAHGRPAILPLA 1212
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Mouse
Match: Mlh3 (mutL homolog 3 [Source:MGI Symbol;Acc:MGI:1353455])

HSP 1 Score: 60.8474 bits (146), Expect = 3.670e-10
Identity = 29/51 (56.86%), Postives = 37/51 (72.55%), Query Frame = 3 
Query:  519 ILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALL 671
            +L S+AC  AIKF D L+ +E  RLI  L+   LPFQCAHGRPS++P+A L
Sbjct: 1318 VLASQACHGAIKFNDRLSLEESCRLIEALSLSQLPFQCAHGRPSMLPLADL 1368
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Mouse
Match: Mlh3 (mutL homolog 3 [Source:MGI Symbol;Acc:MGI:1353455])

HSP 1 Score: 60.8474 bits (146), Expect = 3.670e-10
Identity = 29/51 (56.86%), Postives = 37/51 (72.55%), Query Frame = 3 
Query:  519 ILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALL 671
            +L S+AC  AIKF D L+ +E  RLI  L+   LPFQCAHGRPS++P+A L
Sbjct: 1318 VLASQACHGAIKFNDRLSLEESCRLIEALSLSQLPFQCAHGRPSMLPLADL 1368
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Mouse
Match: Mlh3 (mutL homolog 3 [Source:MGI Symbol;Acc:MGI:1353455])

HSP 1 Score: 60.8474 bits (146), Expect = 3.749e-10
Identity = 29/51 (56.86%), Postives = 37/51 (72.55%), Query Frame = 3 
Query:  519 ILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALL 671
            +L S+AC  AIKF D L+ +E  RLI  L+   LPFQCAHGRPS++P+A L
Sbjct: 1350 VLASQACHGAIKFNDRLSLEESCRLIEALSLSQLPFQCAHGRPSMLPLADL 1400
[Close]
BLAST of DNA mismatch repair protein vs. UniProt/SwissProt
Match: sp|Q97I20|MUTL_CLOAB (DNA mismatch repair protein MutL OS=Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) OX=272562 GN=mutL PE=3 SV=1)

HSP 1 Score: 52.373 bits (124), Expect = 1.608e-12
Identity = 35/126 (27.78%), Postives = 60/126 (47.62%), Query Frame = 3 
Query:  312 YFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELK--VVDIISSILNDPKKDKENIMIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLPMNK 683
            Y+D    V +  GF++     +  +  + + PL L K      P +K   ++II ++ N    +   +    + + AC +A+K    LT DEM+ LI DL     PF C HGRP+++ + +    K
Sbjct:  499 YYDENKEVFKNAGFVIEYFGDN--TVAIKEVPLFLGK------PLVKDLFLEIIDNLKNMGSGETSEVKYRSIATAACKSAVKAYHELTHDEMKTLIQDLRFAEDPFNCPHGRPTIVRLTVTDFEK 616

HSP 2 Score: 41.2022 bits (95), Expect = 1.608e-12
Identity = 21/52 (40.38%), Postives = 30/52 (57.69%), Query Frame = 1 
Query:  118 IIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLEDLQRKCKTKHCLKQ 273
            +IGQF N +I A+S  +     ++ +DQHAAHE+IL E  +   K K    Q
Sbjct:  436 VIGQFNNTYILAESFEE-----LYIIDQHAAHEKILFEKYREDIKNKGVSSQ 482
[Close]
BLAST of DNA mismatch repair protein vs. UniProt/SwissProt
Match: sp|Q0TRD5|MUTL_CLOP1 (DNA mismatch repair protein MutL OS=Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A) OX=195103 GN=mutL PE=3 SV=1)

HSP 1 Score: 56.225 bits (134), Expect = 6.525e-12
Identity = 37/128 (28.91%), Postives = 63/128 (49.22%), Query Frame = 3 
Query:  312 YFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELKVVDIISSILNDPKKDKENIMIDI----LKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLPMNK 683
            Y+D    + EK GF +       +S  + + P  L K        L   ++I+S++N+ KK      +++    + S +C  A+K  D+L+  EM+ LI DL   + PF C HGRP++I      ++K
Sbjct:  551 YYDENKEIFEKAGFKISDFGD--NSIRIEEVPYFLDK--------LNPTELITSMINNLKKMGTGETVEVKYNKIASMSCRAAVKANDVLSILEMENLIEDLRYINDPFHCPHGRPTIIKFTSYELDK 668

HSP 2 Score: 35.4242 bits (80), Expect = 6.525e-12
Identity = 20/60 (33.33%), Postives = 30/60 (50.00%), Query Frame = 1 
Query:   52 YQMIQFPKCSLQVTKNDIYKSHIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLE 231
            Y+  +FPK              +IGQF   +I A+      +  ++ +DQHAAHE+IL E
Sbjct:  478 YREAKFPKL------------RVIGQFNKTYILAE-----YDSTLYLIDQHAAHEKILFE 520
[Close]
BLAST of DNA mismatch repair protein vs. UniProt/SwissProt
Match: sp|Q8XL86|MUTL_CLOPE (DNA mismatch repair protein MutL OS=Clostridium perfringens (strain 13 / Type A) OX=195102 GN=mutL PE=3 SV=1)

HSP 1 Score: 56.225 bits (134), Expect = 6.633e-12
Identity = 37/128 (28.91%), Postives = 63/128 (49.22%), Query Frame = 3 
Query:  312 YFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELKVVDIISSILNDPKKDKENIMIDI----LKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLPMNK 683
            Y+D    + EK GF +       +S  + + P  L K        L   ++I+S++N+ KK      +++    + S +C  A+K  D+L+  EM+ LI DL   + PF C HGRP++I      ++K
Sbjct:  551 YYDENKEIFEKAGFKISDFGD--NSIRIEEVPYFLDK--------LNPTELITSMINNLKKMGTGETVEVKYNKIASMSCRAAVKANDVLSILEMENLIEDLRYINDPFHCPHGRPTIIKFTSYELDK 668

HSP 2 Score: 35.4242 bits (80), Expect = 6.633e-12
Identity = 20/60 (33.33%), Postives = 30/60 (50.00%), Query Frame = 1 
Query:   52 YQMIQFPKCSLQVTKNDIYKSHIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLE 231
            Y+  +FPK              +IGQF   +I A+      +  ++ +DQHAAHE+IL E
Sbjct:  478 YREAKFPKL------------RVIGQFNKTYILAE-----YDSTLYLIDQHAAHEKILFE 520
[Close]
BLAST of DNA mismatch repair protein vs. UniProt/SwissProt
Match: sp|A0Q0M7|MUTL_CLONN (DNA mismatch repair protein MutL OS=Clostridium novyi (strain NT) OX=386415 GN=mutL PE=3 SV=1)

HSP 1 Score: 49.6766 bits (117), Expect = 1.723e-11
Identity = 40/139 (28.78%), Postives = 65/139 (46.76%), Query Frame = 3 
Query:  279 LVTPV----KLRKLEYFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELKVVDIISSILNDPKKDKENIMIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLPMNK 683
            L+TPV          Y+    ++  + GF+      +  S  + +AP+LL    K++  +   ++I   I N    +   I  +++ S AC  AIK    L+ +EM  LI DL     PF C HGRP++I + L  + K
Sbjct:  507 LLTPVIIEMSAEDFAYYSENINIFHESGFVTEVFGDNIIS--IREAPMLL---GKVSTKDF-FLEIFDDIKNMGNGNIAKIKHNMISSLACKAAIKANHTLSYEEMNSLIEDLRYIEEPFNCPHGRPTIIKLTLKEIEK 639

HSP 2 Score: 40.0466 bits (92), Expect = 1.723e-11
Identity = 20/53 (37.74%), Postives = 32/53 (60.38%), Query Frame = 1 
Query:  115 HIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLEDLQRKCKTKHCLKQ 273
            +I+GQF   +I A+S L T     + +DQHAAHE+IL E  + + + +  + Q
Sbjct:  458 NILGQFNKTYILAES-LDT----FYMIDQHAAHEKILFEKFKNQIENRDVISQ 505
[Close]
BLAST of DNA mismatch repair protein vs. UniProt/SwissProt
Match: sp|Q0STR3|MUTL_CLOPS (DNA mismatch repair protein MutL OS=Clostridium perfringens (strain SM101 / Type A) OX=289380 GN=mutL PE=3 SV=1)

HSP 1 Score: 53.9138 bits (128), Expect = 2.899e-11
Identity = 37/128 (28.91%), Postives = 62/128 (48.44%), Query Frame = 3 
Query:  312 YFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELKVVDIISSILNDPKKDKENIMIDI----LKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLPMNK 683
            Y+D    + EK GF +       +S  + + P  L K        L   ++I S++N+ KK      +++    + S +C  A+K  D+L+  EM+ LI DL   + PF C HGRP++I      ++K
Sbjct:  551 YYDENKEIFEKAGFKISDFGD--NSIRIEEVPYFLDK--------LNPTELIISMINNLKKMGTGETVEVKYNKIASMSCRAAVKANDVLSILEMENLIEDLRYINDPFHCPHGRPTIIKFTSYELDK 668

HSP 2 Score: 35.039 bits (79), Expect = 2.899e-11
Identity = 20/60 (33.33%), Postives = 30/60 (50.00%), Query Frame = 1 
Query:   52 YQMIQFPKCSLQVTKNDIYKSHIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLE 231
            Y+  +FPK              +IGQF   +I A+      +  ++ +DQHAAHE+IL E
Sbjct:  478 YREAKFPKL------------KVIGQFNKTYILAE-----YDSTLYLIDQHAAHEKILFE 520
[Close]
BLAST of DNA mismatch repair protein vs. TrEMBL
Match: R9A9B8 (DNA mismatch repair protein MLH3 OS=Wallemia ichthyophaga (strain EXF-994 / CBS 113033) OX=1299270 GN=J056_003240 PE=4 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 1.634e-16
Identity = 44/139 (31.65%), Postives = 78/139 (56.12%), Query Frame = 3 
Query:  279 LVTP---VKLRKLEYFDGIN--SVIEKFGFLLRPCQSSFHSCYLTKAPLL---LLKNEKLTVPELKVVDIISSILNDPKKDKENI---MIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPI 662
            LV+P   V+L  +E +  ++  +++E +G LLRP       C  T   ++   LLK+  L      + DI+   ++   +   +    +++++ SKAC NA KFGD+L+  + Q LI+ L++   P+QCAHGRP++ P+
Sbjct:  101 LVSPSIRVRLTAIEVYTLLSNTAIVEMWGLLLRP-HDEQEVCINTLPNVIHDRLLKDHSL------LRDILRECVDAHNQHTSHTPPTLLNLINSKACRNAFKFGDVLSNTQSQALISALSQTKNPYQCAHGRPTLYPL 232

HSP 2 Score: 47.7506 bits (112), Expect = 1.634e-16
Identity = 25/49 (51.02%), Postives = 34/49 (69.39%), Query Frame = 1 
Query:   85 QVTKNDIYKSHIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLE 231
            ++T+ D+ K+ +IGQ ++KFI A   L T  LLIF  DQHAA ER+ LE
Sbjct:   44 KITRKDLEKTQVIGQVDSKFIVA---LSTNTLLIF--DQHAADERVKLE 87
[Close]
BLAST of DNA mismatch repair protein vs. TrEMBL
Match: A0A4T0IF00 (Uncharacterized protein OS=Wallemia ichthyophaga OX=245174 GN=E3P86_03889 PE=4 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 1.634e-16
Identity = 44/139 (31.65%), Postives = 78/139 (56.12%), Query Frame = 3 
Query:  279 LVTP---VKLRKLEYFDGIN--SVIEKFGFLLRPCQSSFHSCYLTKAPLL---LLKNEKLTVPELKVVDIISSILNDPKKDKENI---MIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPI 662
            LV+P   V+L  +E +  ++  +++E +G LLRP       C  T   ++   LLK+  L      + DI+   ++   +   +    +++++ SKAC NA KFGD+L+  + Q LI+ L++   P+QCAHGRP++ P+
Sbjct:  101 LVSPSIRVRLTAIEVYTLLSNTAIVEMWGLLLRP-HDEQEVCINTLPNVIHDRLLKDHSL------LRDILRECVDAHNQHTSHTPPTLLNLINSKACRNAFKFGDVLSNTQSQALISALSQTKNPYQCAHGRPTLYPL 232

HSP 2 Score: 47.7506 bits (112), Expect = 1.634e-16
Identity = 25/49 (51.02%), Postives = 34/49 (69.39%), Query Frame = 1 
Query:   85 QVTKNDIYKSHIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLE 231
            ++T+ D+ K+ +IGQ ++KFI A   L T  LLIF  DQHAA ER+ LE
Sbjct:   44 KITRKDLEKTQVIGQVDSKFIVA---LSTNTLLIF--DQHAADERVKLE 87
[Close]
BLAST of DNA mismatch repair protein vs. TrEMBL
Match: M4SZP6 (MLH3 (Fragment) OS=Brachionus manjavacas OX=667381 GN=MLH3 PE=4 SV=1)

HSP 1 Score: 75.485 bits (184), Expect = 1.797e-16
Identity = 47/124 (37.90%), Postives = 66/124 (53.23%), Query Frame = 3 
Query:  336 IEKFGFLLRPCQSSFHSCYLTKAPLLLLK--NEKLTVPELKVVDIISSILNDPKKDKENI-------------MIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPI 662
            I K GF +R     +   YL KAP  L+     K ++   KV  +I S L+   K K+N              ++D+  ++AC  AIKFGD L+ D+ + LI  L+ C LPF CAHGRP+V+PI
Sbjct:   81 IRKLGFEIRIDSEKY---YLVKAPRFLVHKIENKESIFLSKVNRVIESELDKSYKQKQNAAKYQLNWSSIPLELMDLFNTEACRGAIKFGDKLSIDKCKELIEKLSSCKLPFSCAHGRPTVVPI 201

HSP 2 Score: 39.2762 bits (90), Expect = 1.797e-16
Identity = 21/46 (45.65%), Postives = 31/46 (67.39%), Query Frame = 1 
Query:  118 IIGQFENKFI--FAKSSLKTRNLL-IFAVDQHAAHERILLEDLQRK 246
            I+GQ + KFI  F+++ ++  + + IF  DQHA HER+ LEDL  K
Sbjct:    1 IMGQIDQKFIVSFSRTQVEGASCVSIFLFDQHACHERVRLEDLLSK 46
[Close]
BLAST of DNA mismatch repair protein vs. TrEMBL
Match: A0A4T0FC43 (MutL_C domain-containing protein OS=Wallemia hederae OX=1540922 GN=E3P99_03982 PE=4 SV=1)

HSP 1 Score: 73.9442 bits (180), Expect = 1.878e-16
Identity = 46/136 (33.82%), Postives = 78/136 (57.35%), Query Frame = 3 
Query:  279 LVTP---VKLRKLEYFDGINS--VIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELKVVDIISSILNDPKKDKENI---MIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPI 662
            LV+P   V+L  LE +  + +  V+E++GFL+R    S     +T  P ++  +++L      + DII   +    +D  +    ++ ++ SKAC NAIKFGD+L+ +E Q L++ L     P+QCAHGRP++ P+
Sbjct:  245 LVSPSIRVQLTALEVYTLLTNPHVVEQWGFLVREHDGSDDVVCITTLPQVI--HDRLLKDLGLLRDIIRECVAAYTQDSSHTPPTLLSLVNSKACRNAIKFGDVLSNEEAQSLLDTLLHTKNPYQCAHGRPTLYPV 378

HSP 2 Score: 40.4318 bits (93), Expect = 1.878e-16
Identity = 22/52 (42.31%), Postives = 35/52 (67.31%), Query Frame = 1 
Query:   79 SLQVTKNDIYKSHIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLED 234
            S ++T++D+ +  +IGQ + KFI A   L ++ +LIF  DQHA  ER+ LE+
Sbjct:  186 SQKITRSDLRQVKVIGQVDKKFIAA---LSSQTMLIF--DQHAVDERVKLEE 232
[Close]
BLAST of DNA mismatch repair protein vs. TrEMBL
Match: A0A4T0HUJ3 (Uncharacterized protein OS=Wallemia ichthyophaga OX=245174 GN=E3P90_04030 PE=4 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 2.102e-16
Identity = 44/139 (31.65%), Postives = 78/139 (56.12%), Query Frame = 3 
Query:  279 LVTP---VKLRKLEYFDGIN--SVIEKFGFLLRPCQSSFHSCYLTKAPLL---LLKNEKLTVPELKVVDIISSILNDPKKDKENI---MIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPI 662
            LV+P   V+L  +E +  ++  +++E +G LLRP       C  T   ++   LLK+  L      + DI+   ++   +   +    +++++ SKAC NA KFGD+L+  + Q LI+ L++   P+QCAHGRP++ P+
Sbjct:   75 LVSPSIRVRLTAIEVYTLLSNTAIVEMWGLLLRP-HDEQEVCINTLPNVIHDRLLKDHSL------LRDILRECVDAHNQHTSHTPPTLLNLINSKACRNAFKFGDVLSNTQSQALISALSQTKNPYQCAHGRPTLYPL 206

HSP 2 Score: 47.3654 bits (111), Expect = 2.102e-16
Identity = 25/49 (51.02%), Postives = 34/49 (69.39%), Query Frame = 1 
Query:   85 QVTKNDIYKSHIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLE 231
            ++T+ D+ K+ +IGQ ++KFI A   L T  LLIF  DQHAA ER+ LE
Sbjct:   18 KITRKDLEKTQVIGQVDSKFIVA---LSTNTLLIF--DQHAADERVKLE 61
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Cavefish
Match: mlh3 (mutL homolog 3 [Source:NCBI gene;Acc:103038515])

HSP 1 Score: 66.6254 bits (161), Expect = 3.634e-12
Identity = 27/52 (51.92%), Postives = 39/52 (75.00%), Query Frame = 3 
Query:  516 DILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALL 671
            ++L S+AC  AIKF D+L+++E   L+  L+ C LPFQCAHGRPS++P+  L
Sbjct: 1089 NVLASQACHGAIKFNDVLSKEECCSLVGSLSSCQLPFQCAHGRPSIVPLVDL 1140
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Sea Lamprey
Match: mlh3 (mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060810-45])

HSP 1 Score: 73.9442 bits (180), Expect = 2.473e-15
Identity = 32/54 (59.26%), Postives = 42/54 (77.78%), Query Frame = 3 
Query:  510 MIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALL 671
            +I +L S+AC  A+KFGD L+ DE   L+ DLAKC LPFQCAHGRP+++P+A L
Sbjct: 1151 IIRVLNSQACHGAVKFGDKLSWDECASLMRDLAKCQLPFQCAHGRPAMMPLANL 1204
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Sea Lamprey
Match: mlh3 (mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060810-45])

HSP 1 Score: 73.9442 bits (180), Expect = 2.872e-15
Identity = 32/54 (59.26%), Postives = 42/54 (77.78%), Query Frame = 3 
Query:  510 MIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALL 671
            +I +L S+AC  A+KFGD L+ DE   L+ DLAKC LPFQCAHGRP+++P+A L
Sbjct: 1315 IIRVLNSQACHGAVKFGDKLSWDECASLMRDLAKCQLPFQCAHGRPAMMPLANL 1368
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Sea Lamprey
Match: mlh3 (mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-060810-45])

HSP 1 Score: 73.9442 bits (180), Expect = 2.876e-15
Identity = 32/54 (59.26%), Postives = 42/54 (77.78%), Query Frame = 3 
Query:  510 MIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALL 671
            +I +L S+AC  A+KFGD L+ DE   L+ DLAKC LPFQCAHGRP+++P+A L
Sbjct: 1328 IIRVLNSQACHGAVKFGDKLSWDECASLMRDLAKCQLPFQCAHGRPAMMPLANL 1381
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Yeast
Match: MLH3 (Protein involved in DNA mismatch repair and meiotic recombination; involved in crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability [Source:SGD;Acc:S000006085])

HSP 1 Score: 65.0846 bits (157), Expect = 1.459e-12
Identity = 30/56 (53.57%), Postives = 40/56 (71.43%), Query Frame = 3 
Query:  504 NIMIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALL 671
             +  +IL SKAC +A+ FGD LT  E   LI+ L++C  PF+CAHGRPS++PIA L
Sbjct:  659 TVFHEILNSKACRSAVMFGDELTRQECIILISKLSRCHNPFECAHGRPSMVPIAEL 714
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Yeast
Match: PMS1 (ATP-binding protein required for mismatch repair; required for both mitosis and meiosis; functions as a heterodimer with Mlh1p; binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL [Source:SGD;Acc:S000005026])

HSP 1 Score: 44.669 bits (104), Expect = 3.009e-11
Identity = 39/141 (27.66%), Postives = 74/141 (52.48%), Query Frame = 3 
Query:  258 TLFKTMSLV--TPVKLRKLEYFDGINS--VIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPEL-KVVDIISSILNDPKKDKENIMIDILKS----KACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSV 653
            T+FK+  L+   PV+L  ++    +++  V EK GF L+  +      + ++  LL L   K T+ +L    ++I  I  D    ++NI    ++S    +AC ++I  G  L +  M R++++L++   P+ C HGRP++
Sbjct:  718 TVFKSQKLIIPQPVELSVIDELVVLDNLPVFEKNGFKLKIDE---EEEFGSRVKLLSLPTSKQTLFDLGDFNELIHLIKEDGGLRRDNIRCSKIRSMFAMRACRSSIMIGKPLNKKTMTRVVHNLSELDKPWNCPHGRPTM 855

HSP 2 Score: 38.5058 bits (88), Expect = 3.009e-11
Identity = 22/54 (40.74%), Postives = 30/54 (55.56%), Query Frame = 1 
Query:   79 SLQVTKNDIYKSHIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLEDLQ 240
            +L V+KND  K  ++GQF   FI     +  +  L F VDQHA+ E+   E LQ
Sbjct:  663 TLTVSKNDFKKMEVVGQFNLGFIIVTRKVDNKYDL-FIVDQHASDEKYNFETLQ 715
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Nematostella
Match: EDO46830 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RP05])

HSP 1 Score: 69.707 bits (169), Expect = 3.033e-14
Identity = 32/65 (49.23%), Postives = 44/65 (67.69%), Query Frame = 3 
Query:  504 NIMIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIP---IALLPMNKDN 689
              ++ +L S+AC  AIKFG+ L   E ++LI DLA C+LPFQCAHGRPS +P   +  LP  +D+
Sbjct:  168 KTILRVLSSQACHGAIKFGEPLAVAECEQLIQDLASCNLPFQCAHGRPSTVPLIDLKRLPNKQDD 232
[Close]
BLAST of DNA mismatch repair protein vs. Ensembl Medaka
Match: mlh3 (mutL homolog 3 [Source:NCBI gene;Acc:101166595])

HSP 1 Score: 64.6994 bits (156), Expect = 5.519e-15
Identity = 43/149 (28.86%), Postives = 71/149 (47.65%), Query Frame = 3 
Query:  276 SLVTPVKL----RKLEYFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELKV--VDIISSILNDPKKDKENIMID--------------ILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPI 662
            ++V P+++     +L       S +   G  +   ++   S ++ K PL  L+ E     ELK     II +I+ +  +++  +++               +L S AC  A+KF D L  DE   L+  L+ C LPFQCAHGRPS+ P+
Sbjct:  946 TIVPPLEISVTEEELRLLSSCRSQLRSLGLEVTFSETQRPSIFVGKVPLCFLEKE---TNELKRGRPSIIKTIVEEYLQEQIELLLSTGRVKRTLPITVLKVLASLACHGAVKFNDTLNRDECHSLVASLSSCQLPFQCAHGRPSIAPL 1091

HSP 2 Score: 34.2686 bits (77), Expect = 5.519e-15
Identity = 21/61 (34.43%), Postives = 32/61 (52.46%), Query Frame = 1 
Query:   85 QVTKNDIYKSHIIGQFENKFI----------FAKSSLKTRNLLIFAVDQHAAHERILLEDL 237
            +++K  I+   ++ Q + KF+           A       NLL+  VDQHAAHER+ LE+L
Sbjct:  866 RLSKAMIHSMKVVDQVDKKFLACLINTREEELASDGDTEGNLLVL-VDQHAAHERVRLENL 925
[Close]
BLAST of DNA mismatch repair protein vs. Planmine SMEST
Match: SMESG000007016.1 (SMESG000007016.1)

HSP 1 Score: 281.952 bits (720), Expect = 9.404e-115
Identity = 140/144 (97.22%), Postives = 140/144 (97.22%), Query Frame = 3 
Query:  264 FKTMSLVTPVKLRKLEYFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELKVVDIISSILNDPKKDKENIMIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLPMNKDNIV 695
             K   LVTPVKLRKLEYFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELKVVDIISSILNDPKKDKENIMIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLPMNKDNIV
Sbjct:   70 LKQCHLVTPVKLRKLEYFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLKNEKLTVPELKVVDIISSILNDPKKDKENIMIDILKSKACCNAIKFGDILTEDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLPMNKDNIV 213

HSP 2 Score: 150.599 bits (379), Expect = 9.404e-115
Identity = 72/74 (97.30%), Postives = 73/74 (98.65%), Query Frame = 1 
Query:   58 MIQFPKCSLQVTKNDIYKSHIIGQFENKFIFAKSSLKTRNLLIFAVDQHAAHERILLEDLQRKCKTKHCLKQCH 279
            MIQFPKCSLQVTKNDIYKSHIIGQFENKFIFAKSSLKT NLLIFA+DQHAAHERILLEDLQRKCKTKHCLKQCH
Sbjct:    1 MIQFPKCSLQVTKNDIYKSHIIGQFENKFIFAKSSLKTGNLLIFAIDQHAAHERILLEDLQRKCKTKHCLKQCH 74
The following BLAST results are available for this feature:
BLAST of DNA mismatch repair protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MLH32.813e-1259.18mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128][more]
MLH32.846e-1159.18mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128][more]
MLH33.614e-1159.18mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128][more]
MLH33.677e-1159.18mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128][more]
MLH33.677e-1159.18mutL homolog 3 [Source:HGNC Symbol;Acc:HGNC:7128][more]
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
pms-22.587e-835.05PMS (Post Meiotic Segregation) family [Source:Uni... [more]
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mlh37.100e-953.85mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE... [more]
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mlh31.744e-1150.94mutL homolog 3 [Source:NCBI gene;Acc:100493832][more]
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Mlh33.670e-1056.86mutL homolog 3 [Source:MGI Symbol;Acc:MGI:1353455][more]
Mlh33.670e-1056.86mutL homolog 3 [Source:MGI Symbol;Acc:MGI:1353455][more]
Mlh33.749e-1056.86mutL homolog 3 [Source:MGI Symbol;Acc:MGI:1353455][more]
back to top
BLAST of DNA mismatch repair protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q97I20|MUTL_CLOAB1.608e-1227.78DNA mismatch repair protein MutL OS=Clostridium ac... [more]
sp|Q0TRD5|MUTL_CLOP16.525e-1228.91DNA mismatch repair protein MutL OS=Clostridium pe... [more]
sp|Q8XL86|MUTL_CLOPE6.633e-1228.91DNA mismatch repair protein MutL OS=Clostridium pe... [more]
sp|A0Q0M7|MUTL_CLONN1.723e-1128.78DNA mismatch repair protein MutL OS=Clostridium no... [more]
sp|Q0STR3|MUTL_CLOPS2.899e-1128.91DNA mismatch repair protein MutL OS=Clostridium pe... [more]
back to top
BLAST of DNA mismatch repair protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
R9A9B81.634e-1631.65DNA mismatch repair protein MLH3 OS=Wallemia ichth... [more]
A0A4T0IF001.634e-1631.65Uncharacterized protein OS=Wallemia ichthyophaga O... [more]
M4SZP61.797e-1637.90MLH3 (Fragment) OS=Brachionus manjavacas OX=667381... [more]
A0A4T0FC431.878e-1633.82MutL_C domain-containing protein OS=Wallemia heder... [more]
A0A4T0HUJ32.102e-1631.65Uncharacterized protein OS=Wallemia ichthyophaga O... [more]
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mlh33.634e-1251.92mutL homolog 3 [Source:NCBI gene;Acc:103038515][more]
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
mlh32.473e-1559.26mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE... [more]
mlh32.872e-1559.26mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE... [more]
mlh32.876e-1559.26mutL homolog 3 (E. coli) [Source:ZFIN;Acc:ZDB-GENE... [more]
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
MLH31.459e-1253.57Protein involved in DNA mismatch repair and meioti... [more]
PMS13.009e-1127.66ATP-binding protein required for mismatch repair; ... [more]
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO468303.033e-1449.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of DNA mismatch repair protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mlh35.519e-1528.86mutL homolog 3 [Source:NCBI gene;Acc:101166595][more]
back to top
BLAST of DNA mismatch repair protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000007016.19.404e-11597.22SMESG000007016.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30029667 ID=SMED30029667|Name=DNA mismatch repair protein|organism=Schmidtea mediterranea sexual|type=transcript|length=754bp
TCTAATTAATTAAAAAGAAGCGTTGTTTATCACAAGTGATGATTAGTTGA
TTATCAAATGATTCAATTTCCAAAATGTTCATTACAAGTAACCAAGAACG
ATATTTATAAATCGCACATTATTGGTCAATTTGAAAACAAATTTATTTTT
GCCAAGTCATCGTTGAAAACGAGAAATTTATTAATATTTGCTGTTGATCA
GCATGCAGCCCATGAAAGAATACTTCTTGAAGATTTGCAAAGGAAGTGTA
AAACTAAACATTGTTTAAAACAATGTCATTAGTAACACCTGTCAAACTTC
GTAAATTGGAATATTTTGATGGGATCAATTCAGTCATAGAAAAATTTGGA
TTTTTATTACGACCGTGCCAATCTTCTTTTCATTCGTGTTATCTTACCAA
GGCACCTTTGTTGCTATTGAAAAATGAAAAATTGACAGTTCCTGAATTAA
AAGTGGTAGACATAATCTCTTCCATTTTAAACGATCCAAAGAAAGATAAA
GAAAACATTATGATTGACATTTTGAAATCAAAGGCATGTTGCAATGCAAT
AAAATTTGGGGACATTTTAACCGAAGATGAAATGCAAAGATTAATAAATG
ATCTTGCTAAATGTTCGTTGCCTTTCCAATGTGCTCACGGAAGACCTTCA
GTTATTCCAATAGCGTTATTACCCATGAATAAAGACAATATTGTGTGACG
ATAATTACTGTAATTTGTTATTGTTTCAAGATTATAAAATAAAAATGAAA
AAAA
back to top

protein sequence of SMED30029667-orf-1

>SMED30029667-orf-1 ID=SMED30029667-orf-1|Name=SMED30029667-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=142bp
MSLVTPVKLRKLEYFDGINSVIEKFGFLLRPCQSSFHSCYLTKAPLLLLK
NEKLTVPELKVVDIISSILNDPKKDKENIMIDILKSKACCNAIKFGDILT
EDEMQRLINDLAKCSLPFQCAHGRPSVIPIALLPMNKDNIV*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0016887ATPase activity
GO:0005524ATP binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000419prepharyngeal region
Vocabulary: INTERPRO
TermDefinition
IPR042120MutL_C_dimsub
IPR037198MutL_C_sf
IPR014790MutL_C
Vocabulary: biological process
TermDefinition
GO:0006298mismatch repair
GO:0007131reciprocal meiotic recombination
Vocabulary: cellular component
TermDefinition
GO:0032300mismatch repair complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR014790MutL, C-terminal, dimerisationPFAMPF08676MutL_Ccoord: 20..71
e-value: 2.8E-8
score: 33.6
IPR042120MutL, C-terminal domain, dimerisation subdomainGENE3DG3DSA:2.30.42.20coord: 11..74
e-value: 4.8E-10
score: 41.1
IPR037198MutL, C-terminal domain superfamilySUPERFAMILYSSF118116DNA mismatch repair protein MutLcoord: 20..66