Secreted peptide prohormone-15
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029602 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Secreted peptide prohormone-15 vs. TrEMBL
Match: E3CTI8 (Secreted peptide prohormone-15 OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 188.348 bits (477), Expect = 2.721e-59 Identity = 95/104 (91.35%), Postives = 101/104 (97.12%), Query Frame = 2 Query: 2 FRFSKMTHVTLLITVGLFHVISGYPQTYELNQSDRGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YERVE 313 FRFSKMTHVTLLITVGLFHVISGYPQTYELNQSDRGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGK+FDPIQFGKRFDPI FG+ ++ ++ Sbjct: 3 FRFSKMTHVTLLITVGLFHVISGYPQTYELNQSDRGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQ 106
BLAST of Secreted peptide prohormone-15 vs. TrEMBL
Match: A0A193PE80 (Neuropeptide-23 (Fragment) OS=Dugesia japonica OX=6161 GN=DjNp23 PE=2 SV=1) HSP 1 Score: 103.605 bits (257), Expect = 1.987e-26 Identity = 51/70 (72.86%), Postives = 63/70 (90.00%), Query Frame = 2 Query: 104 RGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YERVE 313 + + PI+F KRFDPIQFGK+FDPI FGKRFDPIQFGK+FDPI FGK+FDPIQFGK+FDPIMFG+ ++ ++ Sbjct: 3 KKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQ 72 HSP 2 Score: 99.7525 bits (247), Expect = 6.852e-25 Identity = 52/65 (80.00%), Postives = 57/65 (87.69%), Query Frame = 2 Query: 110 YYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YE 304 + PI F K+FDPI FGKRFDPIQFGK+FDPI FGKRFDPIQFGKKFDPI FGKRFDPI FG+ +E Sbjct: 14 FDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFE 78 HSP 3 Score: 95.5153 bits (236), Expect = 3.098e-23 Identity = 49/62 (79.03%), Postives = 55/62 (88.71%), Query Frame = 2 Query: 125 FDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YERV 310 F K+FDPI FGKRFDPIQFGK+FDPI FGKRFDPIQFGKKFDPI FGKRFDPI FG+ ++ + Sbjct: 1 FGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPI 62 HSP 4 Score: 93.2041 bits (230), Expect = 2.259e-22 Identity = 47/68 (69.12%), Postives = 58/68 (85.29%), Query Frame = 2 Query: 77 QTYELNQSDRGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDP 280 + ++ Q + + PI+F KRFDPIQFGK+FDPI FGKRFDPIQFGK+FDPI FGK+FDPIQFGK+F+P Sbjct: 12 KRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFEP 79 HSP 5 Score: 84.3445 bits (207), Expect = 6.761e-19 Identity = 41/54 (75.93%), Postives = 50/54 (92.59%), Query Frame = 2 Query: 152 FGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YERVE 313 FGK+FDPI FGKRFDPIQFGK+FDPI FGK+FDPIQFGK+FDPIMFG+ ++ ++ Sbjct: 1 FGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQ 54
BLAST of Secreted peptide prohormone-15 vs. TrEMBL
Match: A0A193PE85 (Neuropeptide-51 (Fragment) OS=Dugesia japonica OX=6161 GN=DjNp51 PE=2 SV=1) HSP 1 Score: 101.293 bits (251), Expect = 5.018e-25 Identity = 52/81 (64.20%), Postives = 66/81 (81.48%), Query Frame = 2 Query: 71 YPQTYELNQSDRGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YERVE 313 + + ++ Q + + PI+F KRFDPIQFGK+FDPI FGKRFDPIQFGK+FDPI FGK+FDPIQFGK+FDPI FG+ + +E Sbjct: 29 FEKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIQFGKRFYPIE 109 HSP 2 Score: 97.8265 bits (242), Expect = 9.605e-24 Identity = 50/73 (68.49%), Postives = 62/73 (84.93%), Query Frame = 2 Query: 77 QTYELNQSDRGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR 295 + ++ Q + + PI+F KRFDPIQFGK+FDPI FGKRFDPIQFGK+FDPIQFGK+F PI+F +RFDPIMFG+ Sbjct: 49 KRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIQFGKRFYPIEFSRRFDPIMFGK 121 HSP 3 Score: 95.5153 bits (236), Expect = 9.045e-23 Identity = 51/65 (78.46%), Postives = 56/65 (86.15%), Query Frame = 2 Query: 116 PILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YERV 310 PI F K+FDPI FGKRFDPIQFGK+FDPI FGKRFDPIQFGKKFDPIQFGKRF PI F R ++ + Sbjct: 53 PIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIQFGKRFYPIEFSRRFDPI 117 HSP 4 Score: 88.9669 bits (219), Expect = 3.502e-20 Identity = 47/78 (60.26%), Postives = 60/78 (76.92%), Query Frame = 2 Query: 77 QTYELNQSDRGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YERV 310 + ++ +Q + P +F +FD +F KRFDPIQFGK+FDPI FGKRFDPIQFGKKFDPI FGKRFDPI FG+ ++ + Sbjct: 4 KRFDPSQFRMKFDPKMFGDKFDSYRFEKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPI 81 HSP 5 Score: 81.6481 bits (200), Expect = 2.408e-17 Identity = 42/66 (63.64%), Postives = 53/66 (80.30%), Query Frame = 2 Query: 116 PILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YERVE 313 P F +FDP FG +FD +F KRFDPIQFGK+FDPI FGK+FDPIQFGK+FDPIMFG+ ++ ++ Sbjct: 8 PSQFRMKFDPKMFGDKFDSYRFEKRFDPIQFGKKFDPIMFGKRFDPIQFGKKFDPIMFGKRFDPIQ 73
BLAST of Secreted peptide prohormone-15 vs. TrEMBL
Match: A0A1I8IE52 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 77.7962 bits (190), Expect = 5.001e-14 Identity = 42/89 (47.19%), Postives = 57/89 (64.04%), Query Frame = 2 Query: 86 ELNQSDRGYY-PILFDKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKK---FDPIQFGKR---FDPIMFGR 295 E+N R Y+ PI + K+ FDPI +G + FDPI +GK+ FDPI +GK+ FDPI +GKK FDPI +GK+ FDPI +G+ Sbjct: 2203 EVNAEKRAYFDPINYGKKRAYFDPINYGNKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGK 2291 HSP 2 Score: 75.8702 bits (185), Expect = 2.729e-13 Identity = 41/83 (49.40%), Postives = 55/83 (66.27%), Query Frame = 2 Query: 104 RGYY-PILFDKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKK---FDPIQFGKR---FDPIMFGR 295 R Y+ PI + K+ FDPI +GK+ FDPI +GK+ FDPI +GK+ FDPI +GKK FDPI +GK+ FDPI +G+ Sbjct: 2233 RAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGK 2315 HSP 3 Score: 75.8702 bits (185), Expect = 2.729e-13 Identity = 41/83 (49.40%), Postives = 55/83 (66.27%), Query Frame = 2 Query: 104 RGYY-PILFDKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKK---FDPIQFGKR---FDPIMFGR 295 R Y+ PI + K+ FDPI +GK+ FDPI +GK+ FDPI +GK+ FDPI +GKK FDPI +GK+ FDPI +G+ Sbjct: 2257 RAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGK 2339 HSP 4 Score: 75.8702 bits (185), Expect = 2.729e-13 Identity = 41/83 (49.40%), Postives = 55/83 (66.27%), Query Frame = 2 Query: 104 RGYY-PILFDKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKK---FDPIQFGKR---FDPIMFGR 295 R Y+ PI + K+ FDPI +GK+ FDPI +GK+ FDPI +GK+ FDPI +GKK FDPI +GK+ FDPI +G+ Sbjct: 2281 RAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGK 2363 HSP 5 Score: 75.8702 bits (185), Expect = 2.729e-13 Identity = 41/83 (49.40%), Postives = 55/83 (66.27%), Query Frame = 2 Query: 104 RGYY-PILFDKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKK---FDPIQFGKR---FDPIMFGR 295 R Y+ PI + K+ FDPI +GK+ FDPI +GK+ FDPI +GK+ FDPI +GKK FDPI +GK+ FDPI +G+ Sbjct: 2305 RAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGK 2387 HSP 6 Score: 61.2326 bits (147), Expect = 3.582e-8 Identity = 36/76 (47.37%), Postives = 47/76 (61.84%), Query Frame = 2 Query: 104 RGYY-PILFDKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKR---FDPIQFGKKFDPIQF-GKRFDPIMF 289 R Y+ PI + K+ FDPI +GK+ FDPI +GK+ FDPI +GK+ FDPI +GKK Q G FDPI + Sbjct: 2329 RAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYFDPINYGKKRAYYQSRGGYFDPINY 2404
BLAST of Secreted peptide prohormone-15 vs. TrEMBL
Match: A0A267F9R7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig003729g1 PE=4 SV=1) HSP 1 Score: 68.1662 bits (165), Expect = 3.688e-12 Identity = 33/69 (47.83%), Postives = 48/69 (69.57%), Query Frame = 2 Query: 98 SDRGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YE 304 S + + P+L KRFDP+ KRFDP+ KRFDP+ KRFDP+ K++DP+ F KR+DP++F + Y+ Sbjct: 48 STKRFDPLLSMKRFDPLLSMKRFDPLLSMKRFDPLLSMKRFDPLLSMKRYDPLLFRKRYDPLLFRKRYD 116 HSP 2 Score: 67.781 bits (164), Expect = 5.673e-12 Identity = 31/58 (53.45%), Postives = 43/58 (74.14%), Query Frame = 2 Query: 116 PILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMF 289 P+L KRFDP+ KRFDP+ KRFDP+ KR+DP+ F K++DP+ F KR+DP++F Sbjct: 63 PLLSMKRFDPLLSMKRFDPLLSMKRFDPLLSMKRYDPLLFRKRYDPLLFRKRYDPLLF 120 HSP 3 Score: 66.6254 bits (161), Expect = 1.494e-11 Identity = 32/63 (50.79%), Postives = 44/63 (69.84%), Query Frame = 2 Query: 116 PILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YE 304 P+L KRFDP+ KRFDP+ KRFDP+ KRFDP+ K+FDP+ KR+DP++F + Y+ Sbjct: 45 PLLSTKRFDPLLSMKRFDPLLSMKRFDPLLSMKRFDPLLSMKRFDPLLSMKRYDPLLFRKRYD 107 HSP 4 Score: 60.4622 bits (145), Expect = 3.965e-9 Identity = 29/58 (50.00%), Postives = 40/58 (68.97%), Query Frame = 2 Query: 131 KRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR*YE 304 K+FDP+ KRFDP+ KRFDP+ KRFDP+ K+FDP+ KRFDP++ + Y+ Sbjct: 41 KKFDPLLSTKRFDPLLSMKRFDPLLSMKRFDPLLSMKRFDPLLSMKRFDPLLSMKRYD 98
BLAST of Secreted peptide prohormone-15 vs. Ensembl Nematostella
Match: EDO30076 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T1T8]) HSP 1 Score: 48.9062 bits (115), Expect = 1.338e-8 Identity = 19/73 (26.03%), Postives = 34/73 (46.58%), Query Frame = 2 Query: 77 QTYELNQSDRGYYPILFDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPIMFGR 295 Q + Q+ + P+ + Q G+ P+Q G+ P+Q G+ P+Q G+ P+Q G P+ G+ Sbjct: 35 QPIQTAQAGQAIQPMQAGQPIQTAQAGQAIQPMQAGQAIQPMQSGQAIQPMQSGQAIQPMQSGHPIQPMQAGQ 107 HSP 2 Score: 46.2098 bits (108), Expect = 1.528e-7 Identity = 16/53 (30.19%), Postives = 27/53 (50.94%), Query Frame = 2 Query: 125 FDKRFDPIQFGKRFDPIQFGKRFDPIQFGKRFDPIQFGKKFDPIQFGKRFDPI 283 + P+Q G+ P+Q G+ P+Q G+ P+Q G P+Q G+ P+ Sbjct: 60 AGQAIQPMQAGQAIQPMQSGQAIQPMQSGQAIQPMQSGHPIQPMQAGQAIQPM 112 The following BLAST results are available for this feature:
BLAST of Secreted peptide prohormone-15 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Secreted peptide prohormone-15 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Secreted peptide prohormone-15 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Secreted peptide prohormone-15 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 0
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029602 ID=SMED30029602|Name=Secreted peptide prohormone-15|organism=Schmidtea mediterranea sexual|type=transcript|length=384bpback to top Aliases
The feature 'Secreted peptide prohormone-15' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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