CD180 molecule

Overview
NameCD180 molecule
Smed IDSMED30029571
Length (bp)1827
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of CD180 molecule (SMED30029571) t-SNE clustered cells

Violin plots show distribution of expression levels for CD180 molecule (SMED30029571) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of CD180 molecule (SMED30029571) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for CD180 molecule (SMED30029571) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30029571

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30029571SMESG000070311.1 PL08003A2B10ncbi_smed_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
parenchymal cellSMED30029571SMESG000070311.1 dd_Smed_v4_4108_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30029571SMESG000054195.1 SMESG000021688.1 SMESG000021687.1 SMESG000070311.1 Contig48807newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30029571SMESG000054195.1 SMESG000021688.1 SMESG000021687.1 SMESG000070311.1 Contig48807uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of CD180 molecule vs. Ensembl Human
Match: CD180 (CD180 molecule [Source:HGNC Symbol;Acc:HGNC:6726])

HSP 1 Score: 53.5286 bits (127), Expect = 8.856e-7
Identity = 32/95 (33.68%), Postives = 50/95 (52.63%), Query Frame = 2 
Query:  665 LDISSNKITEVKIPEIIEIRN--LNFSNNQLTTIDPEYXXXXXXXXXXXXSHNPLNCLCSESMSFMKWMHNNSHKLVNKNETNCKTPPNTRVIDV 943
            +D+S N +T   I  +  ++   LN + N +  I P  L  +     I++SHNPL+C CS ++ F+ W   N HKL    ET C  PP+ R + +
Sbjct:  525 VDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCS-NIHFLTWYKENLHKLEGSEETTCANPPSLRGVKL 618
[Close]
BLAST of CD180 molecule vs. UniProt/SwissProt
Match: sp|Q99467|CD180_HUMAN (CD180 antigen OS=Homo sapiens OX=9606 GN=CD180 PE=1 SV=2)

HSP 1 Score: 53.5286 bits (127), Expect = 4.253e-6
Identity = 32/95 (33.68%), Postives = 50/95 (52.63%), Query Frame = 2 
Query:  665 LDISSNKITEVKIPEIIEIRN--LNFSNNQLTTIDPEYXXXXXXXXXXXXSHNPLNCLCSESMSFMKWMHNNSHKLVNKNETNCKTPPNTRVIDV 943
            +D+S N +T   I  +  ++   LN + N +  I P  L  +     I++SHNPL+C CS ++ F+ W   N HKL    ET C  PP+ R + +
Sbjct:  525 VDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCS-NIHFLTWYKENLHKLEGSEETTCANPPSLRGVKL 618
[Close]
BLAST of CD180 molecule vs. Planmine SMEST
Match: SMESG000070311.1 (SMESG000070311.1)

HSP 1 Score: 839.721 bits (2168), Expect = 0.000e+0
Identity = 540/549 (98.36%), Postives = 546/549 (99.45%), Query Frame = 2 
Query:   29 MPLILFGILICLINFYELKDCSINGTTMNCARLNFTDCPTVXXXXXXXXXXXXXXXTFSSVNCKTWSNLQRISVKKNKLKNFVSDNVYKLLENLDLSYNNIKEFSVNEKQLLNIDISHNQISVVKYIEGXXXXXXXXXXXXXXXXXXXXXXRILVRIPSLKVLDFSYNKFXXXXXXXXXXXXXQFLSINFSGNQLXXXXXXXXXXXXXXXXXLDISSNKITEVKIPEIIEIRNLNFSNNQLTTIDPEYXXXXXXXXXXXXSHNPLNCLCSESMSFMKWMHNNSHKLVNKNETNCKTPPNTRVIDVDCWXXXXXXXXXXXXXNHNNRIPLDNKSWAXXXXXXXXXXXXXXVFYYCYWRRRGNYQKLEELRSSIPSFSCDCLPLTFLRPRSETDCLINDTNNDNVQYTFNDSRLNFDKSLNVICSRQDKKWVTDKIMCNLDIQKNLICSKKKNIKYGDYTLVIVNDNHCLKDYNLINNLQMCSKGKISTDIRLLVNKMPNYNDFENASFLTDFIKNKVSNNAYFMFNPDKPSICIANLRIWLNLANIPHNV 1675
            MPLILFGILICLINFYELKDCSINGTTMNCARLNFTDCPTVNENILELILDDNLLETFSSVNCKTWSNLQRISVKKNKLKNFVS NVYKLLENLDLSYNNIKEFSVNEKQLLNIDISHNQISVVKYIEGNQLNYFYVNNNNIDNASLDNIIRILVRIPSLKVLDFSYNKFSSLPSSLM+LNSNQFLSINFSGNQLSKISFNIFSSFKI PFNLDISSNKITEVKIPEIIEIRNLNFSNNQLTTIDPEYLNN+ENLINIDISHNPLNCLCSESMSFM+WMHNNSHKLVNKNETNCKTPPNTRVIDVDCWTSTSTKS ITISTNH+NRIPLDNKSWAIPLGIFISILLL+IVFYYCYWRRRGNYQKLEELRSSIPSFSCDCLPLTFLRPRSETDCLINDTNNDNVQYTFNDSRLNFDKSLNVICSRQDKKWVTDKIMCNLDIQKNLICSKKKNIKYGDYTLVIVNDNHCLKDYNLINNLQMCS+GKISTDIRLLVNKMPNYNDFENASFLTDFIKNKVSNNAYFMFNPDKPSICIANLRIWLNLANIPHNV
Sbjct:    1 MPLILFGILICLINFYELKDCSINGTTMNCARLNFTDCPTVNENILELILDDNLLETFSSVNCKTWSNLQRISVKKNKLKNFVSANVYKLLENLDLSYNNIKEFSVNEKQLLNIDISHNQISVVKYIEGNQLNYFYVNNNNIDNASLDNIIRILVRIPSLKVLDFSYNKFSSLPSSLMSLNSNQFLSINFSGNQLSKISFNIFSSFKINPFNLDISSNKITEVKIPEIIEIRNLNFSNNQLTTIDPEYLNNLENLINIDISHNPLNCLCSESMSFMEWMHNNSHKLVNKNETNCKTPPNTRVIDVDCWTSTSTKSSITISTNHSNRIPLDNKSWAIPLGIFISILLLVIVFYYCYWRRRGNYQKLEELRSSIPSFSCDCLPLTFLRPRSETDCLINDTNNDNVQYTFNDSRLNFDKSLNVICSRQDKKWVTDKIMCNLDIQKNLICSKKKNIKYGDYTLVIVNDNHCLKDYNLINNLQMCSEGKISTDIRLLVNKMPNYNDFENASFLTDFIKNKVSNNAYFMFNPDKPSICIANLRIWLNLANIPHNV 549
[Close]
BLAST of CD180 molecule vs. Planmine SMEST
Match: SMESG000070289.1 (SMESG000070289.1)

HSP 1 Score: 154.066 bits (388), Expect = 3.870e-40
Identity = 165/562 (29.36%), Postives = 274/562 (48.75%), Query Frame = 2 
Query:   41 LFGILICLINFYELKDCS-INGTTMNCARLNFTDCPTVXXXXXXXXXXXXXXXTFSSVNCKTWSNLQRISVKKNKLKNFVSDNVYKLLENLDLSYNNIKEFSVNEKQLLNIDISHNQISVVKYIEGXXXXXXXXXXXXXXXXXXXXXXRILVRIPSLK---VLDFSYNKFXXXXXXXXXXXXXQFLSINFSGNQLXXXXXXXXXXXXXXXXXLDISSNKITEVKIPEIIEIRNLNFSNNQLTTIDPEYXXXXXXXXXXXXSHNPLNCLCSESMSFMKWMHNNSHKLVNKNETNCKTPPNTRVIDVDCWXXXXXXXXXXXXXNHNNR-------------IPLDNKSWAXXXXXXXXXXXXXXVF------YYCYWR-RRGNYQKLEELRSSIPSFSCDCLPLTFLRPRSETDCLINDTNNDNVQYTFNDSRLNFDKSLNVICSRQDKKWVTDKIMCNLDIQKNLICSKKKNIKYGDYTLVIVNDNHCLKDYNLINNLQMCSKGKISTDIRLLVNKMPNYNDFENASFLTDFIKNKVSNNAYFMFNPDKPSICIANLRIWLNL 1654
             F + +  +NF E   CS IN T MNC  LN TDCP V E+I  LIL+DNLL+  ++ NC   + L  + ++ N+++      V      LDLS N++   S++ + L  ID+S N I  VK                          ++++R  S+    + DFS NK   +P   M L+ N  +S+N S N  S I+FN F + K   +  + S N I+ + +     +  L+ S+NQL+++D + + N  NL  +D S NPLNCLC+ES SF+ WM  NS   VN+++T CK P N  +  + C   T+  S +  S++   R             IPL   + ++   + I  + + ++       +  Y R RR  Y +         S  C       L    ET                    ++ + SL +ICS +D KWV  +I+ N+ I+  +I +K +N    D+TL++V    CLKDY  +NN++   + + +++ RLLV K+P++      + LT+++++ + +  YF ++   P  C+ ++++WLNL
Sbjct:    6 FFWMFLWSLNFIE--SCSLINKTAMNCTGLNLTDCPIVGESITILILNDNLLQNMTTSNCIKLNGLDSLFLRHNRVQEIPDFQV----RTLDLSQNDLINVSISYEWLDFIDLSENPIKNVKIFAPFLT-------------------KLILRNASINQNILNDFSDNKIEIIPIEFMTLSINGLVSVNLSRNLFSTINFNNFHNNKYQLYIFNFSFNNISTISLTGQRNVNLLDLSHNQLSSVDGDNMENFRNLQLVDFSFNPLNCLCNESRSFIDWMQRNSRIAVNRDQTRCKIPLNQSIFTIKCEDLTTVTSTVNPSSSTTGRISSTPIKVVTTNSIPLTTTTISVGQKLGIFFVSIFLIVLIGAICFMVYIRCRRQGYSEFGPYNGHCCSSMCRVFNPPQLFGSFET--------------------IDSEGSLLIICSSKDTKWVHKEIIANIPIRYQIIDNKVRNWPVFDFTLIVVTGAACLKDYRFVNNVEKALQLRENSETRLLVKKVPDFYKMLIDNPLTEYLRDMMGDRFYFQYDETDPETCLDSMKLWLNL 522
[Close]
BLAST of CD180 molecule vs. Planmine SMEST
Match: SMESG000070289.1 (SMESG000070289.1)

HSP 1 Score: 153.295 bits (386), Expect = 5.954e-40
Identity = 166/554 (29.96%), Postives = 269/554 (48.56%), Query Frame = 2 
Query:   65 INFYELKDCS-INGTTMNCARLNFTDCPTVXXXXXXXXXXXXXXXTFSSVNCKTWSNLQRISVKKNKLKNFVSDNVYKLLENLDLSYNNIKEFSVNEKQLLNIDISHNQISVVKYIEGXXXXXXXXXXXXXXXXXXXXXXRILVRIPSLK---VLDFSYNKFXXXXXXXXXXXXXQFLSINFSGNQLXXXXXXXXXXXXXXXXXLDISSNKITEVKIPEIIEIRNLNFSNNQLTTIDPEYXXXXXXXXXXXXSHNPLNCLCSESMSFMKWMHNNSHKLVNKNETNCKTPPNTRVIDVDCWXXXXXXXXXXXXXNHNNR-------------IPLD------NKSWAXXXXXXXXXXXXXXVFYYCYWR-RRGNYQKLEELRSSIPSFSCDCLPLTFLRPRSETDCLINDTNNDNVQYTFNDSRLNFDKSLNVICSRQDKKWVTDKIMCNLDIQKNLICSKKKNIKYGDYTLVIVNDNHCLKDYNLINNLQMCSKGKISTDIRLLVNKMPNYNDFENASFLTDFIKNKVSNNAYFMFNPDKPSICIANLRIWLNL 1654
            +NF E   CS IN T MNC  LN TDCP V E+I  LIL+DNLL+  ++ NC   + L  + ++ N+++      V      LDLS N++   S++ + L  ID+S N I  VK                          ++++R  S+    + DFS NK   +P   M L+ N  +S+N S N  S I+FN F + K   +  + S N I+ + +     +  L+ S+NQL+++D + + N  NL  +D S NPLNCLC+ES SF+ WM  NS   VN+++T CK P N  +  + C   T+  S +  S++   R             IPL        +   I       I+L+  + +  Y R RR  Y +         S  C       L    ET                    ++ + SL +ICS +D KWV  +I+ N+ I+  +I +K +N    D+TL++V    CLKDY  +NN++   + + +++ RLLV K+P++      + LT+++++ + +  YF ++   P  C+ ++++WLNL
Sbjct:    6 LNFIE--SCSLINKTAMNCTGLNLTDCPIVGESITILILNDNLLQNMTTSNCIKLNGLDSLFLRHNRVQEIPDFQV----RTLDLSQNDLINVSISYEWLDFIDLSENPIKNVKIFAPFLT-------------------KLILRNASINQNILNDFSDNKIEIIPIEFMTLSINGLVSVNLSRNLFSTINFNNFHNNKYQLYIFNFSFNNISTISLTGQRNVNLLDLSHNQLSSVDGDNMENFRNLQLVDFSFNPLNCLCNESRSFIDWMQRNSRIAVNRDQTRCKIPLNQSIFTIKCEDLTTVTSTVNPSSSTTGRISSTPIKVVTTNSIPLTTTTISVGQKLGIFFVSIFLIVLIGAICFMVYIRCRRQGYSEFGPYNGHCCSSMCRVFNPPQLFGSFET--------------------IDSEGSLLIICSSKDTKWVHKEIIANIPIRYQIIDNKVRNWPVFDFTLIVVTGAACLKDYRFVNNVEKALQLRENSETRLLVKKVPDFYKMLIDNPLTEYLRDMMGDRFYFQYDETDPETCLDSMKLWLNL 514
[Close]
BLAST of CD180 molecule vs. Planmine SMEST
Match: SMESG000070289.1 (SMESG000070289.1)

HSP 1 Score: 147.517 bits (371), Expect = 4.788e-38
Identity = 158/538 (29.37%), Postives = 260/538 (48.33%), Query Frame = 2 
Query:  110 MNCARLNFTDCPTVXXXXXXXXXXXXXXXTFSSVNCKTWSNLQRISVKKNKLKNFVSDNVYKLLENLDLSYNNIKEFSVNEKQLLNIDISHNQISVVKYIEGXXXXXXXXXXXXXXXXXXXXXXRILVRIPSLK---VLDFSYNKFXXXXXXXXXXXXXQFLSINFSGNQLXXXXXXXXXXXXXXXXXLDISSNKITEVKIPEIIEIRNLNFSNNQLTTIDPEYXXXXXXXXXXXXSHNPLNCLCSESMSFMKWMHNNSHKLVNKNETNCKTPPNTRVIDVDCWXXXXXXXXXXXXXNHNNR-------------IPLD------NKSWAXXXXXXXXXXXXXXVFYYCYWR-RRGNYQKLEELRSSIPSFSCDCLPLTFLRPRSETDCLINDTNNDNVQYTFNDSRLNFDKSLNVICSRQDKKWVTDKIMCNLDIQKNLICSKKKNIKYGDYTLVIVNDNHCLKDYNLINNLQMCSKGKISTDIRLLVNKMPNYNDFENASFLTDFIKNKVSNNAYFMFNPDKPSICIANLRIWLNL 1654
            MNC  LN TDCP V E+I  LIL+DNLL+  ++ NC   + L  + ++ N+++      V      LDLS N++   S++ + L  ID+S N I  VK                          ++++R  S+    + DFS NK   +P   M L+ N  +S+N S N  S I+FN F + K   +  + S N I+ + +     +  L+ S+NQL+++D + + N  NL  +D S NPLNCLC+ES SF+ WM  NS   VN+++T CK P N  +  + C   T+  S +  S++   R             IPL        +   I       I+L+  + +  Y R RR  Y +         S  C       L    ET                    ++ + SL +ICS +D KWV  +I+ N+ I+  +I +K +N    D+TL++V    CLKDY  +NN++   + + +++ RLLV K+P++      + LT+++++ + +  YF ++   P  C+ ++++WLNL
Sbjct:    1 MNCTGLNLTDCPIVGESITILILNDNLLQNMTTSNCIKLNGLDSLFLRHNRVQEIPDFQV----RTLDLSQNDLINVSISYEWLDFIDLSENPIKNVKIFAPFLT-------------------KLILRNASINQNILNDFSDNKIEIIPIEFMTLSINGLVSVNLSRNLFSTINFNNFHNNKYQLYIFNFSFNNISTISLTGQRNVNLLDLSHNQLSSVDGDNMENFRNLQLVDFSFNPLNCLCNESRSFIDWMQRNSRIAVNRDQTRCKIPLNQSIFTIKCEDLTTVTSTVNPSSSTTGRISSTPIKVVTTNSIPLTTTTISVGQKLGIFFVSIFLIVLIGAICFMVYIRCRRQGYSEFGPYNGHCCSSMCRVFNPPQLFGSFET--------------------IDSEGSLLIICSSKDTKWVHKEIIANIPIRYQIIDNKVRNWPVFDFTLIVVTGAACLKDYRFVNNVEKALQLRENSETRLLVKKVPDFYKMLIDNPLTEYLRDMMGDRFYFQYDETDPETCLDSMKLWLNL 495
[Close]
BLAST of CD180 molecule vs. Planmine SMEST
Match: SMESG000070256.1 (SMESG000070256.1)

HSP 1 Score: 112.079 bits (279), Expect = 2.840e-26
Identity = 116/309 (37.54%), Postives = 175/309 (56.63%), Query Frame = 2 
Query:   23 RKMPLILFGILICLINFYELKDCSINGTTMNCARLNFTDCPTVXXXXXXXXXXXXXXXTFSSVNCKTWSNLQRISVKKNKLKNFVSDNVYKLLENLDLSYNNIKEFSVNEKQLLNIDISHNQISVVKYIEGXXXXXXXXXXXXXXXXXXXXXXRILVRIPSLKVLDFSYNKFXXXXXXXXXXXXXQFLSINFSGNQLXXXXXXXXXXXXXXXXXLDISSNKITEVKIPEIIEIRNLNFSNNQLTTIDPEYXXXXXXXXXXXXSHNPLNCLCSESMSFMKWMHNNSHKLVNKNETNCKTPPNTRVIDVDC 949
            +   LI+ G+ + LI       C      M+C     TDCP  N+++  LILD+N L    + NCK W+NL  +SV+KNKLKN ++   +K+L  LDLS N +   +++  QL  +++S N +S ++ +    +     +NN +   +  N+I  L + PSL VLD S N+ +SLP  LM  N+N+ L+IN S NQLS ++FN F   KI    ++ S N+I ++ I   +    L+FSNNQL+ ++ E L+   NL  ID S NPL+C C+ES SF+ WM  +   +VN   T CK P   R+ +V C
Sbjct:    2 KSFRLIVLGLCVSLI---AGGPCKTTKNIMDCKGKGLTDCPAANKSVTVLILDENNLTDLRTKNCKNWTNLISLSVRKNKLKNSLTFETFKVLGFLDLSENQLSSLALSGDQLSVVNVSSNFLSGLE-VNLPNVLQLIASNNRMGKLNFGNLILDLHKSPSLTVLDVSRNRINSLPVDLMTFNNNKNLTINLSRNQLSYVNFNYFVDNKIGFN-INFSFNRIADIDIDSKLHFGYLDFSNNQLSKVNGEKLDRFVNLNGIDFSQNPLSCFCNESESFINWMIKHKAIVVNPQNTMCKYPSKIRIFEVKC 305
The following BLAST results are available for this feature:
BLAST of CD180 molecule vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
CD1808.856e-733.68CD180 molecule [Source:HGNC Symbol;Acc:HGNC:6726][more]
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BLAST of CD180 molecule vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 1
Match NameE-valueIdentityDescription
sp|Q99467|CD180_HUMAN4.253e-633.68CD180 antigen OS=Homo sapiens OX=9606 GN=CD180 PE=... [more]
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BLAST of CD180 molecule vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of CD180 molecule vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000070311.10.000e+098.36SMESG000070311.1[more]
SMESG000070289.13.870e-4029.36SMESG000070289.1[more]
SMESG000070289.15.954e-4029.96SMESG000070289.1[more]
SMESG000070289.14.788e-3829.37SMESG000070289.1[more]
SMESG000070256.12.840e-2637.54SMESG000070256.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30029571 ID=SMED30029571|Name=CD180 molecule|organism=Schmidtea mediterranea sexual|type=transcript|length=1827bp
ATCTATATAAATCTTATATGAAAGGAAGATGCCATTAATTTTATTTGGAA
TATTAATATGTTTAATTAATTTTTATGAATTGAAAGACTGCTCAATTAAT
GGCACAACTATGAATTGTGCTAGACTTAATTTCACAGATTGTCCAACTGT
TAATGAAAATATTTTAGAGCTTATTCTCGATGATAATTTGTTGGAAACGT
TTTCTAGTGTCAATTGTAAAACTTGGAGTAACTTGCAAAGGATAAGTGTT
AAGAAAAATAAACTTAAAAATTTTGTGAGTGATAATGTTTATAAACTGCT
AGAAAACTTGGATTTGAGTTATAATAATATCAAGGAATTTAGTGTAAATG
AAAAACAATTACTAAATATTGATATTTCACATAATCAGATTTCTGTTGTA
AAATATATCGAAGGAAATCAATTAAATTATTTCTATGTTAACAATAATAA
TATTGACAATGCTTCGTTGGATAATATAATTAGAATTCTGGTTAGAATTC
CTTCTCTAAAGGTTTTGGATTTTAGTTACAATAAATTTTCCAGTTTACCA
AGTTCTCTCATGAATTTAAATTCAAATCAATTTCTATCGATAAATTTCTC
TGGAAATCAATTATCTAAAATATCTTTCAATATTTTCTCATCATTTAAGA
TAATTCCATTTAATTTGGATATTTCATCTAATAAAATCACCGAGGTGAAA
ATTCCAGAGATTATTGAAATAAGAAATTTGAACTTTTCTAACAACCAGCT
GACCACAATTGATCCCGAATATCTGAATAACATAGAAAATCTGATAAATA
TTGATATTTCTCACAATCCTCTCAATTGTTTGTGCAGCGAATCGATGTCA
TTCATGAAATGGATGCACAATAACAGTCATAAATTGGTGAATAAAAATGA
AACGAATTGTAAAACTCCACCGAATACACGAGTAATCGATGTCGATTGCT
GGACGTCAACGTCAACGAAATCACCAATCACAATATCGACCAATCACAAC
AATCGCATCCCATTGGATAATAAATCATGGGCAATTCCTCTCGGGATTTT
CATTTCCATTCTTTTATTAATAATTGTATTTTATTATTGTTATTGGCGGA
GAAGAGGGAACTATCAGAAACTGGAAGAATTACGGAGCTCCATCCCGTCA
TTTAGCTGTGATTGCTTACCTTTGACATTCCTCCGGCCGAGATCCGAGAC
TGATTGCCTGATCAATGATACGAATAATGACAATGTCCAATATACCTTCA
ATGACAGTCGTTTGAATTTTGATAAATCATTGAATGTGATCTGTTCAAGA
CAAGACAAGAAATGGGTAACTGATAAAATCATGTGTAATCTAGATATTCA
AAAGAATTTAATTTGTTCAAAAAAGAAAAATATAAAATATGGAGATTATA
CATTAGTCATTGTAAATGACAACCATTGCCTCAAAGACTATAATCTTATT
AATAATCTACAAATGTGCTCGAAAGGGAAAATTTCCACGGATATTCGACT
TTTAGTCAACAAAATGCCTAATTATAACGACTTCGAGAACGCGTCCTTTC
TGACAGATTTCATCAAAAACAAGGTATCAAACAACGCCTATTTCATGTTC
AATCCGGACAAACCTTCCATTTGTATAGCTAATTTGAGAATTTGGTTAAA
TTTGGCAAATATCCCCCACAACGTGTGACATCCTGAAATAGACCTTTTAT
GACCACTCCGTTGCAATTTTTTACAGTAAATGCCATTTTGTTTGTGGCAT
GAATATTTGAAAAATTTGAAGGCACTATTTTTGAATTTAACAAATTTTAA
TAAATTGGAAATATTTTTATTTATTTG
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protein sequence of SMED30029571-orf-1

>SMED30029571-orf-1 ID=SMED30029571-orf-1|Name=SMED30029571-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=550bp
MPLILFGILICLINFYELKDCSINGTTMNCARLNFTDCPTVNENILELIL
DDNLLETFSSVNCKTWSNLQRISVKKNKLKNFVSDNVYKLLENLDLSYNN
IKEFSVNEKQLLNIDISHNQISVVKYIEGNQLNYFYVNNNNIDNASLDNI
IRILVRIPSLKVLDFSYNKFSSLPSSLMNLNSNQFLSINFSGNQLSKISF
NIFSSFKIIPFNLDISSNKITEVKIPEIIEIRNLNFSNNQLTTIDPEYLN
NIENLINIDISHNPLNCLCSESMSFMKWMHNNSHKLVNKNETNCKTPPNT
RVIDVDCWTSTSTKSPITISTNHNNRIPLDNKSWAIPLGIFISILLLIIV
FYYCYWRRRGNYQKLEELRSSIPSFSCDCLPLTFLRPRSETDCLINDTNN
DNVQYTFNDSRLNFDKSLNVICSRQDKKWVTDKIMCNLDIQKNLICSKKK
NIKYGDYTLVIVNDNHCLKDYNLINNLQMCSKGKISTDIRLLVNKMPNYN
DFENASFLTDFIKNKVSNNAYFMFNPDKPSICIANLRIWLNLANIPHNV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0002322B cell proliferation involved in immune response
GO:0031666positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0071222cellular response to lipopolysaccharide
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR032675LRR_dom_sf
IPR001611Leu-rich_rpt
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR032675Leucine-rich repeat domain superfamilyGENE3DG3DSA:3.80.10.10coord: 212..328
e-value: 2.1E-14
score: 55.4
coord: 21..92
e-value: 2.4E-5
score: 26.1
IPR032675Leucine-rich repeat domain superfamilyGENE3DG3DSA:3.80.10.10coord: 93..203
e-value: 2.4E-11
score: 45.1
NoneNo IPR availablePANTHERPTHR45712:SF22coord: 21..224
NoneNo IPR availablePANTHERPTHR45712FAMILY NOT NAMEDcoord: 112..331
NoneNo IPR availablePANTHERPTHR45712FAMILY NOT NAMEDcoord: 21..224
NoneNo IPR availablePANTHERPTHR45712:SF22coord: 112..331
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..21
score: 0.631
NoneNo IPR availableSUPERFAMILYSSF52058L domain-likecoord: 113..312
NoneNo IPR availableSUPERFAMILYSSF52058L domain-likecoord: 40..126
NoneNo IPR availableTMHMMTMhelixcoord: 337..359
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 93..114
score: 7.573
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 233..254
score: 6.541
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 187..208
score: 4.747
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 47..68
score: 5.132
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 162..184
score: 7.173
IPR001611Leucine-rich repeatPROSITEPS51450LRRcoord: 257..278
score: 5.494