Selenoprotein W
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029518 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 12
Homology
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752]) HSP 1 Score: 66.2402 bits (160), Expect = 3.993e-15 Identity = 35/77 (45.45%), Postives = 46/77 (59.74%), Query Frame = 1 Query: 28 VVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 VV+ G++S +LK K FP +L I TP T +FEV V GK+IHSKK GDG+VD ++K + AI AL Sbjct: 7 VVYCGAGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 83
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752]) HSP 1 Score: 63.5438 bits (153), Expect = 4.101e-14 Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 Query: 22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 +V G++S +LK K FP +L I TP T +FEV V GK+IHSKK GDG+VD ++K + AI AL Sbjct: 6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752]) HSP 1 Score: 63.5438 bits (153), Expect = 4.101e-14 Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 Query: 22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 +V G++S +LK K FP +L I TP T +FEV V GK+IHSKK GDG+VD ++K + AI AL Sbjct: 6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752]) HSP 1 Score: 63.5438 bits (153), Expect = 4.101e-14 Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 Query: 22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 +V G++S +LK K FP +L I TP T +FEV V GK+IHSKK GDG+VD ++K + AI AL Sbjct: 6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752]) HSP 1 Score: 63.1586 bits (152), Expect = 5.003e-14 Identity = 33/71 (46.48%), Postives = 43/71 (60.56%), Query Frame = 1 Query: 46 GFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 G++S +LK K FP +L I TP T +FEV V GK+IHSKK GDG+VD ++K + AI AL Sbjct: 15 GYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 85
BLAST of Selenoprotein W vs. Ensembl Zebrafish
Match: selenow1 (selenoprotein W, 1 [Source:NCBI gene;Acc:352915]) HSP 1 Score: 78.1814 bits (191), Expect = 4.808e-20 Identity = 34/59 (57.63%), Postives = 45/59 (76.27%), Query Frame = 1 Query: 70 LKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 L+ +FPN+L IT TP T W EVEVNGK++HSKKNGDGFVD+ +K++ I AI +A+ Sbjct: 26 LEDEFPNELEITGEGTPSTTGWLEVEVNGKLVHSKKNGDGFVDSDSKMQKIVTAIEQAM 84
BLAST of Selenoprotein W vs. Ensembl Mouse
Match: Selenow (selenoprotein W [Source:MGI Symbol;Acc:MGI:1100878]) HSP 1 Score: 61.6178 bits (148), Expect = 1.455e-13 Identity = 28/66 (42.42%), Postives = 40/66 (60.61%), Query Frame = 1 Query: 49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 + + +L+ +FP L I TP T +FEV V GK++HSKK GDG+VD ++K + AI AL Sbjct: 19 YLQLKEKLEHEFPGCLDICGEGTPQVTGFFEVTVAGKLVHSKKRGDGYVDTESKFRKLVTAIKAAL 84
BLAST of Selenoprotein W vs. Ensembl Mouse
Match: Selenov (selenoprotein V [Source:MGI Symbol;Acc:MGI:3608324]) HSP 1 Score: 52.373 bits (124), Expect = 7.168e-9 Identity = 29/64 (45.31%), Postives = 39/64 (60.94%), Query Frame = 1 Query: 58 FERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEALK 249 +R L+ +FPN L T FEV V+GK+IHSKK GDGFVD ++ L+ + AI E +K Sbjct: 264 LKRTLEHQFPNLLEFEEERATQVTGEFEVFVDGKLIHSKKKGDGFVD-ESGLKKLVGAIDEEIK 326
BLAST of Selenoprotein W vs. Ensembl Mouse
Match: Selenov (selenoprotein V [Source:MGI Symbol;Acc:MGI:3608324]) HSP 1 Score: 43.1282 bits (100), Expect = 9.842e-7 Identity = 23/41 (56.10%), Postives = 28/41 (68.29%), Query Frame = 1 Query: 127 TSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEALK 249 T FEV V+GK+IHSKK GDGFVD L+ + AI E +K Sbjct: 5 TGEFEVFVDGKLIHSKKKGDGFVDESG-LKKLVGAIDEEIK 44
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|Q568W0|SELW_DANRE (Selenoprotein W OS=Danio rerio OX=7955 GN=selenow PE=3 SV=3) HSP 1 Score: 78.5666 bits (192), Expect = 2.481e-19 Identity = 34/59 (57.63%), Postives = 45/59 (76.27%), Query Frame = 1 Query: 70 LKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 L+ +FPN+L IT TP T W EVEVNGK++HSKKNGDGFVD+ +K++ I AI +A+ Sbjct: 26 LEDEFPNELEITGEGTPSTTGWLEVEVNGKLVHSKKNGDGFVDSDSKMQKIMTAIEQAM 84
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|D0EYG3|SELW_CHICK (Selenoprotein W OS=Gallus gallus OX=9031 GN=SELENOW PE=2 SV=1) HSP 1 Score: 68.1662 bits (165), Expect = 2.609e-15 Identity = 31/66 (46.97%), Postives = 40/66 (60.61%), Query Frame = 1 Query: 49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 + EL+ +FP L + T + T WFEV V +++HSKKNGDGFVD AKL+ I AI AL Sbjct: 19 YERLRAELEKRFPGALEMRGQGTQEVTGWFEVTVGSRLVHSKKNGDGFVDTDAKLQRIVAAIQAAL 84
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|Q5NVB2|SELW_PONAB (Selenoprotein W OS=Pongo abelii OX=9601 GN=SELENOW PE=3 SV=4) HSP 1 Score: 63.5438 bits (153), Expect = 1.970e-13 Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 Query: 22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 +V G++S +LK K FP +L I TP T +FEV V GK+IHSKK GDG+VD ++K + AI AL Sbjct: 6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|P63303|SELW_MACMU (Selenoprotein W OS=Macaca mulatta OX=9544 GN=SELENOW PE=1 SV=3) HSP 1 Score: 63.5438 bits (153), Expect = 1.970e-13 Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 Query: 22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 +V G++S +LK K FP +L I TP T +FEV V GK+IHSKK GDG+VD ++K + AI AL Sbjct: 6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|P63302|SELW_HUMAN (Selenoprotein W OS=Homo sapiens OX=9606 GN=SELENOW PE=1 SV=3) HSP 1 Score: 63.5438 bits (153), Expect = 1.970e-13 Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 Query: 22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 +V G++S +LK K FP +L I TP T +FEV V GK+IHSKK GDG+VD ++K + AI AL Sbjct: 6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
BLAST of Selenoprotein W vs. TrEMBL
Match: K7GJT9 (Selenoprotein W OS=Pelodiscus sinensis OX=13735 GN=SELENOW PE=4 SV=1) HSP 1 Score: 80.4925 bits (197), Expect = 6.862e-18 Identity = 37/66 (56.06%), Postives = 45/66 (68.18%), Query Frame = 1 Query: 49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 +R ++EL+ +FP +L IT TP T WFEV V GK++HSK NGDGFVDN KL I AI EAL Sbjct: 1 YRQLKKELEKQFPGKLEITGEGTPQVTGWFEVTVAGKLVHSKMNGDGFVDNSTKLSKIVAAIKEAL 66
BLAST of Selenoprotein W vs. TrEMBL
Match: M4QNV7 (Selenoprotein W OS=Cristaria plicata OX=165446 PE=2 SV=1) HSP 1 Score: 79.7221 bits (195), Expect = 2.203e-17 Identity = 38/67 (56.72%), Postives = 46/67 (68.66%), Query Frame = 1 Query: 49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEALK 249 FR E EL+ KFP +L I+S ATP T +FEVEV+GK++HSKK GDG+VD AKL I I LK Sbjct: 19 FRKLEAELQKKFPGKLEISSEATPTVTGFFEVEVDGKLLHSKKGGDGYVDTDAKLRKIVDGIQAKLK 85
BLAST of Selenoprotein W vs. TrEMBL
Match: A0A2G9RI05 (Uncharacterized protein OS=Lithobates catesbeianus OX=8400 GN=AB205_0032390 PE=4 SV=1) HSP 1 Score: 79.7221 bits (195), Expect = 3.773e-17 Identity = 36/69 (52.17%), Postives = 48/69 (69.57%), Query Frame = 1 Query: 43 MGFRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEALK 249 + F+ +REL+ +FP QL ATP T W EV+VNGK++HSKKNGDG+VD ++KL I A+ ALK Sbjct: 37 LRFQQLQRELEKRFPGQLEFEGEATPTATGWLEVKVNGKLVHSKKNGDGYVDKESKLLKIVAAVEAALK 105
BLAST of Selenoprotein W vs. TrEMBL
Match: Q8H6T4 (Selenoprotein SelW1 OS=Chlamydomonas reinhardtii OX=3055 GN=SelW1 PE=2 SV=2) HSP 1 Score: 78.9518 bits (193), Expect = 5.123e-17 Identity = 38/67 (56.72%), Postives = 49/67 (73.13%), Query Frame = 1 Query: 49 FRSFERELKLKFPNQLVITSF-ATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 +RS E +++KFPN + SF ATP T +FEVEVNG+++HSKKNG G VDN+ K+E IF I EAL Sbjct: 20 YRSLENAIRMKFPNADIKFSFEATPQATGFFEVEVNGELVHSKKNGGGHVDNQEKVERIFAKIGEAL 86
BLAST of Selenoprotein W vs. TrEMBL
Match: V8NVW9 (Uncharacterized protein (Fragment) OS=Ophiophagus hannah OX=8665 GN=L345_08127 PE=4 SV=1) HSP 1 Score: 78.5666 bits (192), Expect = 7.116e-17 Identity = 37/66 (56.06%), Postives = 47/66 (71.21%), Query Frame = 1 Query: 49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 F+ ++EL+ +FP +L I+ TP T WFEV V GK++HSKKNGDGFVDN AKL I +AI AL Sbjct: 20 FQKLKKELEKEFPGKLEISGEETPQVTGWFEVMVAGKMVHSKKNGDGFVDNDAKLSKIIKAIRTAL 85
BLAST of Selenoprotein W vs. Ensembl Cavefish
Match: selenow1 (selenoprotein W, 1 [Source:NCBI gene;Acc:352915]) HSP 1 Score: 74.3294 bits (181), Expect = 7.570e-19 Identity = 33/68 (48.53%), Postives = 47/68 (69.12%), Query Frame = 1 Query: 43 MGFRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 MG+ + L+ +FP L I+ +TP + WFEVEVNGK++HSKKNGDGFVD+ K+ I AI +++ Sbjct: 1 MGYTKLKTLLEDEFPGDLEISGESTPRTSGWFEVEVNGKLVHSKKNGDGFVDSDQKMAKIVSAIEKSI 68
BLAST of Selenoprotein W vs. Ensembl Cavefish
Match: selenow1 (selenoprotein W, 1 [Source:NCBI gene;Acc:352915]) HSP 1 Score: 70.8626 bits (172), Expect = 2.177e-17 Identity = 34/71 (47.89%), Postives = 47/71 (66.20%), Query Frame = 1 Query: 46 GFRSFERELKL----KFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 G+R +LK +FP L I+ +TP + WFEVEVNGK++HSKKNGDGFVD+ K+ I AI +++ Sbjct: 3 GYRPKYTKLKTLLEDEFPGDLEISGESTPRTSGWFEVEVNGKLVHSKKNGDGFVDSDQKMAKIVSAIEKSI 73
BLAST of Selenoprotein W vs. Ensembl Cavefish
Match: selenow1 (selenoprotein W, 1 [Source:NCBI gene;Acc:352915]) HSP 1 Score: 69.707 bits (169), Expect = 6.043e-17 Identity = 31/59 (52.54%), Postives = 43/59 (72.88%), Query Frame = 1 Query: 70 LKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 L+ +FP L I+ +TP + WFEVEVNGK++HSKKNGDGFVD+ K+ I AI +++ Sbjct: 14 LEDEFPGDLEISGESTPRTSGWFEVEVNGKLVHSKKNGDGFVDSDQKMAKIVSAIEKSI 72
BLAST of Selenoprotein W vs. Ensembl Nematostella
Match: EDO35675 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKT9]) HSP 1 Score: 68.9366 bits (167), Expect = 3.008e-17 Identity = 29/53 (54.72%), Postives = 44/53 (83.02%), Query Frame = 1 Query: 88 NQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246 N++ +TS+ATP+ T +FEV VN +++HSKKNGDG+VD++ KL IF +I++AL Sbjct: 13 NEVEVTSYATPNVTGYFEVSVNDQLVHSKKNGDGYVDSEKKLAKIFDSITKAL 65 The following BLAST results are available for this feature:
BLAST of Selenoprotein W vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Selenoprotein W vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Selenoprotein W vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Selenoprotein W vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of Selenoprotein W vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Selenoprotein W vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 3
BLAST of Selenoprotein W vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Selenoprotein W vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Selenoprotein W vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 3
BLAST of Selenoprotein W vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Selenoprotein W vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Selenoprotein W vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Selenoprotein W vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Selenoprotein W vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 0
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029518 ID=SMED30029518|Name=Selenoprotein W|organism=Schmidtea mediterranea sexual|type=transcript|length=317bpback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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