Selenoprotein W

Overview
NameSelenoprotein W
Smed IDSMED30029518
Length (bp)317
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Selenoprotein W (SMED30029518) t-SNE clustered cells

Violin plots show distribution of expression levels for Selenoprotein W (SMED30029518) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Selenoprotein W (SMED30029518) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Selenoprotein W (SMED30029518) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30029518

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30029518 SmedASXL_004791SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
pharynxSMED30029518 dd_Smed_v4_572_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30029518 dd_Smed_v4_572_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30029518 dd_Smed_v4_572_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30029518 dd_Smed_v4_572_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30029518 dd_Smed_v4_572_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30029518 dd_Smed_v4_572_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30029518 dd_Smed_v4_572_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30029518 dd_Smed_v4_572_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30029518 Contig50126newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30029518 Contig50126uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
neoblastSMED30029518 dd_Smed_v6_572_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752])

HSP 1 Score: 66.2402 bits (160), Expect = 3.993e-15
Identity = 35/77 (45.45%), Postives = 46/77 (59.74%), Query Frame = 1 
Query:   28 VVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            VV+   G++S   +LK K    FP +L I    TP  T +FEV V GK+IHSKK GDG+VD ++K   +  AI  AL
Sbjct:    7 VVYCGAGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 83
[Close]
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752])

HSP 1 Score: 63.5438 bits (153), Expect = 4.101e-14
Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 
Query:   22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
             +V     G++S   +LK K    FP +L I    TP  T +FEV V GK+IHSKK GDG+VD ++K   +  AI  AL
Sbjct:    6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
[Close]
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752])

HSP 1 Score: 63.5438 bits (153), Expect = 4.101e-14
Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 
Query:   22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
             +V     G++S   +LK K    FP +L I    TP  T +FEV V GK+IHSKK GDG+VD ++K   +  AI  AL
Sbjct:    6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
[Close]
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752])

HSP 1 Score: 63.5438 bits (153), Expect = 4.101e-14
Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 
Query:   22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
             +V     G++S   +LK K    FP +L I    TP  T +FEV V GK+IHSKK GDG+VD ++K   +  AI  AL
Sbjct:    6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
[Close]
BLAST of Selenoprotein W vs. Ensembl Human
Match: SELENOW (selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752])

HSP 1 Score: 63.1586 bits (152), Expect = 5.003e-14
Identity = 33/71 (46.48%), Postives = 43/71 (60.56%), Query Frame = 1 
Query:   46 GFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            G++S   +LK K    FP +L I    TP  T +FEV V GK+IHSKK GDG+VD ++K   +  AI  AL
Sbjct:   15 GYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 85
[Close]
BLAST of Selenoprotein W vs. Ensembl Zebrafish
Match: selenow1 (selenoprotein W, 1 [Source:NCBI gene;Acc:352915])

HSP 1 Score: 78.1814 bits (191), Expect = 4.808e-20
Identity = 34/59 (57.63%), Postives = 45/59 (76.27%), Query Frame = 1 
Query:   70 LKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            L+ +FPN+L IT   TP  T W EVEVNGK++HSKKNGDGFVD+ +K++ I  AI +A+
Sbjct:   26 LEDEFPNELEITGEGTPSTTGWLEVEVNGKLVHSKKNGDGFVDSDSKMQKIVTAIEQAM 84
[Close]
BLAST of Selenoprotein W vs. Ensembl Mouse
Match: Selenow (selenoprotein W [Source:MGI Symbol;Acc:MGI:1100878])

HSP 1 Score: 61.6178 bits (148), Expect = 1.455e-13
Identity = 28/66 (42.42%), Postives = 40/66 (60.61%), Query Frame = 1 
Query:   49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            +   + +L+ +FP  L I    TP  T +FEV V GK++HSKK GDG+VD ++K   +  AI  AL
Sbjct:   19 YLQLKEKLEHEFPGCLDICGEGTPQVTGFFEVTVAGKLVHSKKRGDGYVDTESKFRKLVTAIKAAL 84
[Close]
BLAST of Selenoprotein W vs. Ensembl Mouse
Match: Selenov (selenoprotein V [Source:MGI Symbol;Acc:MGI:3608324])

HSP 1 Score: 52.373 bits (124), Expect = 7.168e-9
Identity = 29/64 (45.31%), Postives = 39/64 (60.94%), Query Frame = 1 
Query:   58 FERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEALK 249
             +R L+ +FPN L          T  FEV V+GK+IHSKK GDGFVD ++ L+ +  AI E +K
Sbjct:  264 LKRTLEHQFPNLLEFEEERATQVTGEFEVFVDGKLIHSKKKGDGFVD-ESGLKKLVGAIDEEIK 326
[Close]
BLAST of Selenoprotein W vs. Ensembl Mouse
Match: Selenov (selenoprotein V [Source:MGI Symbol;Acc:MGI:3608324])

HSP 1 Score: 43.1282 bits (100), Expect = 9.842e-7
Identity = 23/41 (56.10%), Postives = 28/41 (68.29%), Query Frame = 1 
Query:  127 TSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEALK 249
            T  FEV V+GK+IHSKK GDGFVD    L+ +  AI E +K
Sbjct:    5 TGEFEVFVDGKLIHSKKKGDGFVDESG-LKKLVGAIDEEIK 44
[Close]
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|Q568W0|SELW_DANRE (Selenoprotein W OS=Danio rerio OX=7955 GN=selenow PE=3 SV=3)

HSP 1 Score: 78.5666 bits (192), Expect = 2.481e-19
Identity = 34/59 (57.63%), Postives = 45/59 (76.27%), Query Frame = 1 
Query:   70 LKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            L+ +FPN+L IT   TP  T W EVEVNGK++HSKKNGDGFVD+ +K++ I  AI +A+
Sbjct:   26 LEDEFPNELEITGEGTPSTTGWLEVEVNGKLVHSKKNGDGFVDSDSKMQKIMTAIEQAM 84
[Close]
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|D0EYG3|SELW_CHICK (Selenoprotein W OS=Gallus gallus OX=9031 GN=SELENOW PE=2 SV=1)

HSP 1 Score: 68.1662 bits (165), Expect = 2.609e-15
Identity = 31/66 (46.97%), Postives = 40/66 (60.61%), Query Frame = 1 
Query:   49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            +     EL+ +FP  L +    T + T WFEV V  +++HSKKNGDGFVD  AKL+ I  AI  AL
Sbjct:   19 YERLRAELEKRFPGALEMRGQGTQEVTGWFEVTVGSRLVHSKKNGDGFVDTDAKLQRIVAAIQAAL 84
[Close]
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|Q5NVB2|SELW_PONAB (Selenoprotein W OS=Pongo abelii OX=9601 GN=SELENOW PE=3 SV=4)

HSP 1 Score: 63.5438 bits (153), Expect = 1.970e-13
Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 
Query:   22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
             +V     G++S   +LK K    FP +L I    TP  T +FEV V GK+IHSKK GDG+VD ++K   +  AI  AL
Sbjct:    6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
[Close]
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|P63303|SELW_MACMU (Selenoprotein W OS=Macaca mulatta OX=9544 GN=SELENOW PE=1 SV=3)

HSP 1 Score: 63.5438 bits (153), Expect = 1.970e-13
Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 
Query:   22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
             +V     G++S   +LK K    FP +L I    TP  T +FEV V GK+IHSKK GDG+VD ++K   +  AI  AL
Sbjct:    6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
[Close]
BLAST of Selenoprotein W vs. UniProt/SwissProt
Match: sp|P63302|SELW_HUMAN (Selenoprotein W OS=Homo sapiens OX=9606 GN=SELENOW PE=1 SV=3)

HSP 1 Score: 63.5438 bits (153), Expect = 1.970e-13
Identity = 34/79 (43.04%), Postives = 45/79 (56.96%), Query Frame = 1 
Query:   22 NLVVHEDMGFRSFERELKLK----FPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
             +V     G++S   +LK K    FP +L I    TP  T +FEV V GK+IHSKK GDG+VD ++K   +  AI  AL
Sbjct:    6 RVVYCGAUGYKSKYLQLKKKLEDEFPGRLDICGEGTPQATGFFEVMVAGKLIHSKKKGDGYVDTESKFLKLVAAIKAAL 84
[Close]
BLAST of Selenoprotein W vs. TrEMBL
Match: K7GJT9 (Selenoprotein W OS=Pelodiscus sinensis OX=13735 GN=SELENOW PE=4 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 6.862e-18
Identity = 37/66 (56.06%), Postives = 45/66 (68.18%), Query Frame = 1 
Query:   49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            +R  ++EL+ +FP +L IT   TP  T WFEV V GK++HSK NGDGFVDN  KL  I  AI EAL
Sbjct:    1 YRQLKKELEKQFPGKLEITGEGTPQVTGWFEVTVAGKLVHSKMNGDGFVDNSTKLSKIVAAIKEAL 66
[Close]
BLAST of Selenoprotein W vs. TrEMBL
Match: M4QNV7 (Selenoprotein W OS=Cristaria plicata OX=165446 PE=2 SV=1)

HSP 1 Score: 79.7221 bits (195), Expect = 2.203e-17
Identity = 38/67 (56.72%), Postives = 46/67 (68.66%), Query Frame = 1 
Query:   49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEALK 249
            FR  E EL+ KFP +L I+S ATP  T +FEVEV+GK++HSKK GDG+VD  AKL  I   I   LK
Sbjct:   19 FRKLEAELQKKFPGKLEISSEATPTVTGFFEVEVDGKLLHSKKGGDGYVDTDAKLRKIVDGIQAKLK 85
[Close]
BLAST of Selenoprotein W vs. TrEMBL
Match: A0A2G9RI05 (Uncharacterized protein OS=Lithobates catesbeianus OX=8400 GN=AB205_0032390 PE=4 SV=1)

HSP 1 Score: 79.7221 bits (195), Expect = 3.773e-17
Identity = 36/69 (52.17%), Postives = 48/69 (69.57%), Query Frame = 1 
Query:   43 MGFRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEALK 249
            + F+  +REL+ +FP QL     ATP  T W EV+VNGK++HSKKNGDG+VD ++KL  I  A+  ALK
Sbjct:   37 LRFQQLQRELEKRFPGQLEFEGEATPTATGWLEVKVNGKLVHSKKNGDGYVDKESKLLKIVAAVEAALK 105
[Close]
BLAST of Selenoprotein W vs. TrEMBL
Match: Q8H6T4 (Selenoprotein SelW1 OS=Chlamydomonas reinhardtii OX=3055 GN=SelW1 PE=2 SV=2)

HSP 1 Score: 78.9518 bits (193), Expect = 5.123e-17
Identity = 38/67 (56.72%), Postives = 49/67 (73.13%), Query Frame = 1 
Query:   49 FRSFERELKLKFPNQLVITSF-ATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            +RS E  +++KFPN  +  SF ATP  T +FEVEVNG+++HSKKNG G VDN+ K+E IF  I EAL
Sbjct:   20 YRSLENAIRMKFPNADIKFSFEATPQATGFFEVEVNGELVHSKKNGGGHVDNQEKVERIFAKIGEAL 86
[Close]
BLAST of Selenoprotein W vs. TrEMBL
Match: V8NVW9 (Uncharacterized protein (Fragment) OS=Ophiophagus hannah OX=8665 GN=L345_08127 PE=4 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 7.116e-17
Identity = 37/66 (56.06%), Postives = 47/66 (71.21%), Query Frame = 1 
Query:   49 FRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            F+  ++EL+ +FP +L I+   TP  T WFEV V GK++HSKKNGDGFVDN AKL  I +AI  AL
Sbjct:   20 FQKLKKELEKEFPGKLEISGEETPQVTGWFEVMVAGKMVHSKKNGDGFVDNDAKLSKIIKAIRTAL 85
[Close]
BLAST of Selenoprotein W vs. Ensembl Cavefish
Match: selenow1 (selenoprotein W, 1 [Source:NCBI gene;Acc:352915])

HSP 1 Score: 74.3294 bits (181), Expect = 7.570e-19
Identity = 33/68 (48.53%), Postives = 47/68 (69.12%), Query Frame = 1 
Query:   43 MGFRSFERELKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            MG+   +  L+ +FP  L I+  +TP  + WFEVEVNGK++HSKKNGDGFVD+  K+  I  AI +++
Sbjct:    1 MGYTKLKTLLEDEFPGDLEISGESTPRTSGWFEVEVNGKLVHSKKNGDGFVDSDQKMAKIVSAIEKSI 68
[Close]
BLAST of Selenoprotein W vs. Ensembl Cavefish
Match: selenow1 (selenoprotein W, 1 [Source:NCBI gene;Acc:352915])

HSP 1 Score: 70.8626 bits (172), Expect = 2.177e-17
Identity = 34/71 (47.89%), Postives = 47/71 (66.20%), Query Frame = 1 
Query:   46 GFRSFERELKL----KFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            G+R    +LK     +FP  L I+  +TP  + WFEVEVNGK++HSKKNGDGFVD+  K+  I  AI +++
Sbjct:    3 GYRPKYTKLKTLLEDEFPGDLEISGESTPRTSGWFEVEVNGKLVHSKKNGDGFVDSDQKMAKIVSAIEKSI 73
[Close]
BLAST of Selenoprotein W vs. Ensembl Cavefish
Match: selenow1 (selenoprotein W, 1 [Source:NCBI gene;Acc:352915])

HSP 1 Score: 69.707 bits (169), Expect = 6.043e-17
Identity = 31/59 (52.54%), Postives = 43/59 (72.88%), Query Frame = 1 
Query:   70 LKLKFPNQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            L+ +FP  L I+  +TP  + WFEVEVNGK++HSKKNGDGFVD+  K+  I  AI +++
Sbjct:   14 LEDEFPGDLEISGESTPRTSGWFEVEVNGKLVHSKKNGDGFVDSDQKMAKIVSAIEKSI 72
[Close]
BLAST of Selenoprotein W vs. Ensembl Nematostella
Match: EDO35675 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SKT9])

HSP 1 Score: 68.9366 bits (167), Expect = 3.008e-17
Identity = 29/53 (54.72%), Postives = 44/53 (83.02%), Query Frame = 1 
Query:   88 NQLVITSFATPDQTSWFEVEVNGKVIHSKKNGDGFVDNKAKLENIFQAISEAL 246
            N++ +TS+ATP+ T +FEV VN +++HSKKNGDG+VD++ KL  IF +I++AL
Sbjct:   13 NEVEVTSYATPNVTGYFEVSVNDQLVHSKKNGDGYVDSEKKLAKIFDSITKAL 65
The following BLAST results are available for this feature:
BLAST of Selenoprotein W vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SELENOW3.993e-1545.45selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752... [more]
SELENOW4.101e-1443.04selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752... [more]
SELENOW4.101e-1443.04selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752... [more]
SELENOW4.101e-1443.04selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752... [more]
SELENOW5.003e-1446.48selenoprotein W [Source:HGNC Symbol;Acc:HGNC:10752... [more]
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BLAST of Selenoprotein W vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Selenoprotein W vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Selenoprotein W vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
selenow14.808e-2057.63selenoprotein W, 1 [Source:NCBI gene;Acc:352915][more]
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BLAST of Selenoprotein W vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Selenoprotein W vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Selenow1.455e-1342.42selenoprotein W [Source:MGI Symbol;Acc:MGI:1100878... [more]
Selenov7.168e-945.31selenoprotein V [Source:MGI Symbol;Acc:MGI:3608324... [more]
Selenov9.842e-756.10selenoprotein V [Source:MGI Symbol;Acc:MGI:3608324... [more]
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BLAST of Selenoprotein W vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q568W0|SELW_DANRE2.481e-1957.63Selenoprotein W OS=Danio rerio OX=7955 GN=selenow ... [more]
sp|D0EYG3|SELW_CHICK2.609e-1546.97Selenoprotein W OS=Gallus gallus OX=9031 GN=SELENO... [more]
sp|Q5NVB2|SELW_PONAB1.970e-1343.04Selenoprotein W OS=Pongo abelii OX=9601 GN=SELENOW... [more]
sp|P63303|SELW_MACMU1.970e-1343.04Selenoprotein W OS=Macaca mulatta OX=9544 GN=SELEN... [more]
sp|P63302|SELW_HUMAN1.970e-1343.04Selenoprotein W OS=Homo sapiens OX=9606 GN=SELENOW... [more]
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BLAST of Selenoprotein W vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
K7GJT96.862e-1856.06Selenoprotein W OS=Pelodiscus sinensis OX=13735 GN... [more]
M4QNV72.203e-1756.72Selenoprotein W OS=Cristaria plicata OX=165446 PE=... [more]
A0A2G9RI053.773e-1752.17Uncharacterized protein OS=Lithobates catesbeianus... [more]
Q8H6T45.123e-1756.72Selenoprotein SelW1 OS=Chlamydomonas reinhardtii O... [more]
V8NVW97.116e-1756.06Uncharacterized protein (Fragment) OS=Ophiophagus ... [more]
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BLAST of Selenoprotein W vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
selenow17.570e-1948.53selenoprotein W, 1 [Source:NCBI gene;Acc:352915][more]
selenow12.177e-1747.89selenoprotein W, 1 [Source:NCBI gene;Acc:352915][more]
selenow16.043e-1752.54selenoprotein W, 1 [Source:NCBI gene;Acc:352915][more]
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BLAST of Selenoprotein W vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Selenoprotein W vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Selenoprotein W vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO356753.008e-1754.72Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Selenoprotein W vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Selenoprotein W vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 0
Match NameE-valueIdentityDescription
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30029518 ID=SMED30029518|Name=Selenoprotein W|organism=Schmidtea mediterranea sexual|type=transcript|length=317bp
ATGTTTTCTATTATTTTCAATAATTTAGTGGTGCATGAGGATATGGGATT
CCGGAGTTTCGAAAGAGAACTGAAACTTAAATTTCCCAATCAACTAGTTA
TAACTTCATTTGCCACGCCTGACCAAACTTCGTGGTTTGAAGTAGAAGTT
AATGGTAAAGTTATCCATTCTAAAAAGAATGGTGACGGTTTTGTCGACAA
CAAGGCCAAGCTAGAAAATATATTTCAAGCAATAAGCGAAGCTTTAAAAT
AGTTCATGTTTCTTAAATGCTAATCTTATGATGGTTATTGGAAAAATTAT
TCTTCAATAATCTGAAG
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
Vocabulary: molecular function
TermDefinition
GO:0016209antioxidant activity
Vocabulary: biological process
TermDefinition
GO:0098869cellular oxidant detoxification
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000429neoblast
PLANA:0002032epidermal cell
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR036249Thioredoxin-like_sf
IPR012336Thioredoxin-like_fold
IPR011893Selenoprotein_Rdx-typ
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR036249Thioredoxin-like superfamilyGENE3DG3DSA:3.40.30.10coord: 2..83
e-value: 7.3E-21
score: 76.1
IPR036249Thioredoxin-like superfamilySUPERFAMILYSSF52833Thioredoxin-likecoord: 19..78
IPR011893Selenoprotein, Rdx-typePFAMPF10262Rdxcoord: 17..72
e-value: 1.5E-7
score: 31.5
IPR011893Selenoprotein, Rdx-typeTIGRFAMTIGR02174TIGR02174coord: 17..74
e-value: 9.2E-13
score: 46.3
NoneNo IPR availablePANTHERPTHR15124SELENOPROTEIN Wcoord: 16..83
NoneNo IPR availablePANTHERPTHR15124:SF18SELENOPROTEIN Wcoord: 16..83