KN motif and ankyrin repeat domain-containing protein 4 isoform X2

Overview


Name	KN motif and ankyrin repeat domain-containing protein 4 isoform X2
Smed ID	SMED30029492
Length (bp)	4723

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 (SMED30029492) t-SNE clustered cells

Violin plots show distribution of expression levels for KN motif and ankyrin repeat domain-containing protein 4 isoform X2 (SMED30029492) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 (SMED30029492) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30029492

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30029492	h1SMcG0001759	dd_Smed_v4_7499_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30029492	h1SMcG0001759	dd_Smed_v4_7499_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30029492	h1SMcG0001759	dd_Smed_v4_7499_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30029492	h1SMcG0001759	dd_Smed_v4_7499_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30029492	h1SMcG0001759	dd_Smed_v4_7499_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
Category 4 cell	SMED30029492	h1SMcG0001759	dd_Smed_v4_7499_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017
dorsal region of the epidermis	SMED30029492	h1SMcG0001759	dd_Smed_v4_7499_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

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Homology

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BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Human
Match: KANK4 (KN motif and ankyrin repeat domains 4 [Source:HGNC Symbol;Acc:HGNC:27263])

HSP 1 Score: 93.9745 bits (232), Expect = 1.738e-19
Identity = 64/248 (25.81%), Postives = 127/248 (51.21%), Query Frame = 3

Query: 3717 WLNTSKLVSMNNIEHMPQ------EMIKPCLMLI--DWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLA--ATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLA-EQNNFSEISALFTQRRSIRRS 4427
            +LN  + +S    +H+P+      ++++  L  I  +W+     K SS  ++ +  + +   + +F+K LV   D  GNT +HY + H  +    ++  TG+ + +  N  G+T +M+   A+ +  +++    + KL  + ++N+Q+ + GQTA+ L   HD ++ +  L +  AD+N++D + ++ LM+A    N+  V+ +LA P     L +K G +AL +A +     EI+ L        RS
Sbjct:  123 FLNACRALS----QHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAV--VWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRS 364

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Human
Match: KANK4 (KN motif and ankyrin repeat domains 4 [Source:HGNC Symbol;Acc:HGNC:27263])

HSP 1 Score: 93.5893 bits (231), Expect = 1.876e-19
Identity = 64/248 (25.81%), Postives = 127/248 (51.21%), Query Frame = 3

Query: 3717 WLNTSKLVSMNNIEHMPQ------EMIKPCLMLI--DWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLA--ATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLA-EQNNFSEISALFTQRRSIRRS 4427
            +LN  + +S    +H+P+      ++++  L  I  +W+     K SS  ++ +  + +   + +F+K LV   D  GNT +HY + H  +    ++  TG+ + +  N  G+T +M+   A+ +  +++    + KL  + ++N+Q+ + GQTA+ L   HD ++ +  L +  AD+N++D + ++ LM+A    N+  V+ +LA P     L +K G +AL +A +     EI+ L        RS
Sbjct:  107 FLNACRALS----QHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAV--VWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRS 348

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Human
Match: KANK4 (KN motif and ankyrin repeat domains 4 [Source:HGNC Symbol;Acc:HGNC:27263])

HSP 1 Score: 93.5893 bits (231), Expect = 2.259e-18
Identity = 64/248 (25.81%), Postives = 127/248 (51.21%), Query Frame = 3

Query: 3717 WLNTSKLVSMNNIEHMPQ------EMIKPCLMLI--DWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLA--ATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLA-EQNNFSEISALFTQRRSIRRS 4427
            +LN  + +S    +H+P+      ++++  L  I  +W+     K SS  ++ +  + +   + +F+K LV   D  GNT +HY + H  +    ++  TG+ + +  N  G+T +M+   A+ +  +++    + KL  + ++N+Q+ + GQTA+ L   HD ++ +  L +  AD+N++D + ++ LM+A    N+  V+ +LA P     L +K G +AL +A +     EI+ L        RS
Sbjct:  751 FLNACRALS----QHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAV--VWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRS 992

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Human
Match: KANK3 (KN motif and ankyrin repeat domains 3 [Source:HGNC Symbol;Acc:HGNC:24796])

HSP 1 Score: 90.8929 bits (224), Expect = 1.439e-17
Identity = 64/240 (26.67%), Postives = 117/240 (48.75%), Query Frame = 3

Query: 3789 LMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHI-RKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEI-SGYSKILSSNSNPISPRTFRKYT 4502
            L+  +W+     + S  + +  +   +       +  +V   D  GNT +HY + H      S++  TG  + N  N  G++ +MLAA   V  E  +  + ++L    D+N ++ + GQTA+ L+  H   + + TL A GAD+N +D++  T LM A+    +  V+ +L  PG    + + +G SAL +A +    E++AL     S  + +  +G  +   S+  P  PR F+K++
Sbjct:  578 LVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQAGVQRHNLSSLQPPPPR-FKKFS 816

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Human
Match: KANK1 (KN motif and ankyrin repeat domains 1 [Source:HGNC Symbol;Acc:HGNC:19309])

HSP 1 Score: 87.8113 bits (216), Expect = 1.470e-17
Identity = 58/204 (28.43%), Postives = 106/204 (51.96%), Query Frame = 3

Query: 3885 NFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNPISPRTFRK 4496
            + +++++   D  GNT +HY + H  +E   ++    + + +  N  G+T +MLAA   V  E     + +L    D+N ++ + GQTA+ L+  H   + +  L A GAD+NI+D E +T LM A+   +++ VK +LA PG    L++ DG++AL +A +    +I+ L     +  +++            +P +PR  RK
Sbjct:  149 DVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQ------------SPGTPRLGRK 340

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BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Celegans
Match: vab-19 (VAB-19 [Source:UniProtKB/TrEMBL;Acc:G5EDN8])

HSP 1 Score: 95.5153 bits (236), Expect = 2.201e-19
Identity = 60/186 (32.26%), Postives = 100/186 (53.76%), Query Frame = 3

Query: 3900 LVIN-RDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKIL 4454
            +V+N  DQ GNT +HY + H  +   S I  +G  D +  N  G+T +MLAA  Q+ D++    + +L    ++N ++ +HGQTA+ L+  H    T   L A GA++N +D + +T LM A    + + VK +LA   V   L + D ++AL +A +N+  EI  +     +  R +ISG +  +
Sbjct:  855 MVVNFCDQNGNTALHYAVSHANFAVVSSILDSGECDLDAPNRAGYTAVMLAALSQLDDDMEKAVVHRLFQMGNVNAKASQHGQTALMLAVSHGKKTTTELLLACGANVNEQDQDGSTALMCAAEHGHKELVKMLLAENLVNASLTDVDNSTALSIALENDHREIGVMIYAYLNYGRLDISGPTSTI 1040

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Fly
Match: Kank (gene:FBgn0027596 transcript:FBtr0303758)

HSP 1 Score: 98.9821 bits (245), Expect = 3.752e-21
Identity = 57/203 (28.08%), Postives = 105/203 (51.72%), Query Frame = 3

Query: 3888 FVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNPISPRTFRK 4496
             +++ V   D  GNT MHY + H  ++  S++  + + D N  N  G+T +ML +  ++        + +L   AD+N+++K+H QTA+ L+  H N + +  L   GADINI+D + +T LM A     +  +K +L+ P     + + DG++A K+A Q    ++  L      + RS++       ++ S+ ISP   ++
Sbjct:  242 LLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVHEQMLRSKLPNRGD--ATRSSLISPPRHKR 442

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Fly
Match: Kank (gene:FBgn0027596 transcript:FBtr0087429)

HSP 1 Score: 96.2857 bits (238), Expect = 1.872e-19
Identity = 53/182 (29.12%), Postives = 96/182 (52.75%), Query Frame = 3

Query: 3888 FVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEI 4433
             +++ V   D  GNT MHY + H  ++  S++  + + D N  N  G+T +ML +  ++        + +L   AD+N+++K+H QTA+ L+  H N + +  L   GADINI+D + +T LM A     +  +K +L+ P     + + DG++A K+A Q    ++  L      + RS++
Sbjct: 1097 LLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVHEQMLRSKL 1278

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Fly
Match: Kank (gene:FBgn0027596 transcript:FBtr0112929)

HSP 1 Score: 95.9005 bits (237), Expect = 2.572e-19
Identity = 53/182 (29.12%), Postives = 96/182 (52.75%), Query Frame = 3

Query: 3888 FVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEI 4433
             +++ V   D  GNT MHY + H  ++  S++  + + D N  N  G+T +ML +  ++        + +L   AD+N+++K+H QTA+ L+  H N + +  L   GADINI+D + +T LM A     +  +K +L+ P     + + DG++A K+A Q    ++  L      + RS++
Sbjct: 1135 LLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVHEQMLRSKL 1316

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Fly
Match: Kank (gene:FBgn0027596 transcript:FBtr0332856)

HSP 1 Score: 95.5153 bits (236), Expect = 2.631e-19
Identity = 53/182 (29.12%), Postives = 96/182 (52.75%), Query Frame = 3

Query: 3888 FVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEI 4433
             +++ V   D  GNT MHY + H  ++  S++  + + D N  N  G+T +ML +  ++        + +L   AD+N+++K+H QTA+ L+  H N + +  L   GADINI+D + +T LM A     +  +K +L+ P     + + DG++A K+A Q    ++  L      + RS++
Sbjct:  835 LLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVHEQMLRSKL 1016

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Fly
Match: Kank (gene:FBgn0027596 transcript:FBtr0303756)

HSP 1 Score: 95.5153 bits (236), Expect = 2.762e-19
Identity = 53/182 (29.12%), Postives = 96/182 (52.75%), Query Frame = 3

Query: 3888 FVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEI 4433
             +++ V   D  GNT MHY + H  ++  S++  + + D N  N  G+T +ML +  ++        + +L   AD+N+++K+H QTA+ L+  H N + +  L   GADINI+D + +T LM A     +  +K +L+ P     + + DG++A K+A Q    ++  L      + RS++
Sbjct:  859 LLEYCVNLSDSNGNTAMHYAVSHGNFDVVSILLDSKVCDVNQMNNAGYTSVMLVSLAKLKQPAHRTVVERLFKMADVNIRAKKHCQTALMLAVSHGNGDMVNMLLDAGADINIQDEDGSTALMCAAEHGRVDVIKHLLSHPECDSLVTDVDGSTAFKIAWQAGHRDVGLLIYVHEQMLRSKL 1040

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Zebrafish
Match: kank1b (KN motif and ankyrin repeat domains 1b [Source:ZFIN;Acc:ZDB-GENE-060526-260])

HSP 1 Score: 98.2117 bits (243), Expect = 3.465e-20
Identity = 65/244 (26.64%), Postives = 122/244 (50.00%), Query Frame = 3

Query: 3681 ENIFQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLI--DWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLA--ATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF 4400
            E +      + + LN SK +S  N EH      + CL  +  +W+     K    Q++    +     + + + ++    DQ GNT +HY + H  +    V+ A G+ + +  N  G+T +MLA  A ++  ++++   +++L  + D+N ++ + GQTA+ L+  H   + +  L A GA++NI+D E ++ LM A    +   VK +LA PG    L + D ++AL +A +    +I+ L 
Sbjct:  392 EKMLSACQTLEIHLNGSKTIS--NREH------RSCLSTVQQEWFCVSSQKRVCPQIVEDFLFACCQVSPDVLCYVANMPDQNGNTALHYSVSHSNFSVVKVLLAAGVCNIDHQNKAGYTPIMLASLAAVETKEDMIV--VQELFSRGDVNAKASQAGQTALMLAVSHGRLDMVQALLAAGAEVNIQDDEGSSALMCAGEHGHADIVKLLLAQPGCDATLTDNDESTALSIALEAGHKDIAMLI 625

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Zebrafish
Match: kank3 (KN motif and ankyrin repeat domains 3 [Source:ZFIN;Acc:ZDB-GENE-081105-185])

HSP 1 Score: 94.7449 bits (234), Expect = 3.726e-20
Identity = 63/231 (27.27%), Postives = 119/231 (51.52%), Query Frame = 3

Query: 3798 IDWWVDMVIKLSSNQLLTTVQYLI--STFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNPISPR 4484
            ++W+     K++  Q L    YL+  S  +   ++ +V   D  GNT +HY + H  +    ++  TG+ + N  N  G+T +MLAA   V +E     ++KL    ++N ++ + GQTA+ L+  H     +  L   GA++NI+D E +T LM A+     + V  +L  PG  + + + DG++AL +A + + ++I+ L     +  +++     K  +++ +P SPR
Sbjct:  114 LEWFRVSSAKMA--QPLRVSNYLMAFSEVSPVLLEHIVNMTDGNGNTALHYSVSHSNFAVVDLLLDTGMCNVNQQNKAGYTAVMLAALSAVKEEDEMAVVQKLFRLGNVNAKASQAGQTALMLAVSHGRQEMVRALLDCGANVNIQDDEGSTALMCASEHGRAEIVSLLLEQPGCDISIVDNDGSNALSIALEASHNDIAVLLYAHMNYSKTQADASPK--ANSRSPSSPR 340

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Zebrafish
Match: kank1a (KN motif and ankyrin repeat domains 1a [Source:ZFIN;Acc:ZDB-GENE-060526-215])

HSP 1 Score: 96.2857 bits (238), Expect = 2.369e-19
Identity = 68/281 (24.20%), Postives = 138/281 (49.11%), Query Frame = 3

Query: 3690 FQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLI--DWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAA--TLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKI-LSSNSNPISPRTFRKYTYN*SR 4517
            +++S +++   N  K   +N+ + +  + ++PC+  +  +W+     K +  +++        + +   ++ +V   D  GNT +HY + H  +     +    + + N  N  G+T +MLAA   ++ P ++    + +L  K D+N ++ + GQT + L+  H   + +  L A GAD+NI+D E +T LM A+   +++ VK +LA PG    L + D ++AL +A +    +I+ L              Y+ +  S   +P +PR  RK + + +R
Sbjct: 1040 YELSEKMLSACNILK-SHLNDPKALSSKDVRPCVNTVQHEWFRVSSQKTAVAEMVEDYLNAFRSISPALLQHIVNMADGNGNTALHYSVSHSNFHIVKKLLEADVCNVNQQNKAGYTPIMLAALAAVEAPKDM--RVVDELFSKGDVNAKASQAGQTGLMLAVSHGRMDMVKALLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCDPTLSDNDESNALSIALEAGHKDIAVLL-------------YAHMNFSKAQSPGTPRLGRKTSPSPTR 1304

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Zebrafish
Match: kank1a (KN motif and ankyrin repeat domains 1a [Source:ZFIN;Acc:ZDB-GENE-060526-215])

HSP 1 Score: 96.2857 bits (238), Expect = 2.614e-19
Identity = 68/281 (24.20%), Postives = 138/281 (49.11%), Query Frame = 3

Query: 3690 FQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLI--DWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAA--TLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKI-LSSNSNPISPRTFRKYTYN*SR 4517
            +++S +++   N  K   +N+ + +  + ++PC+  +  +W+     K +  +++        + +   ++ +V   D  GNT +HY + H  +     +    + + N  N  G+T +MLAA   ++ P ++    + +L  K D+N ++ + GQT + L+  H   + +  L A GAD+NI+D E +T LM A+   +++ VK +LA PG    L + D ++AL +A +    +I+ L              Y+ +  S   +P +PR  RK + + +R
Sbjct: 1032 YELSEKMLSACNILK-SHLNDPKALSSKDVRPCVNTVQHEWFRVSSQKTAVAEMVEDYLNAFRSISPALLQHIVNMADGNGNTALHYSVSHSNFHIVKKLLEADVCNVNQQNKAGYTPIMLAALAAVEAPKDM--RVVDELFSKGDVNAKASQAGQTGLMLAVSHGRMDMVKALLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCDPTLSDNDESNALSIALEAGHKDIAVLL-------------YAHMNFSKAQSPGTPRLGRKTSPSPTR 1296

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Zebrafish
Match: kank3 (KN motif and ankyrin repeat domains 3 [Source:ZFIN;Acc:ZDB-GENE-081105-185])

HSP 1 Score: 95.9005 bits (237), Expect = 2.772e-19
Identity = 63/231 (27.27%), Postives = 119/231 (51.52%), Query Frame = 3

Query: 3798 IDWWVDMVIKLSSNQLLTTVQYLI--STFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNPISPR 4484
            ++W+     K++  Q L    YL+  S  +   ++ +V   D  GNT +HY + H  +    ++  TG+ + N  N  G+T +MLAA   V +E     ++KL    ++N ++ + GQTA+ L+  H     +  L   GA++NI+D E +T LM A+     + V  +L  PG  + + + DG++AL +A + + ++I+ L     +  +++     K  +++ +P SPR
Sbjct:  682 LEWFRVSSAKMA--QPLRVSNYLMAFSEVSPVLLEHIVNMTDGNGNTALHYSVSHSNFAVVDLLLDTGMCNVNQQNKAGYTAVMLAALSAVKEEDEMAVVQKLFRLGNVNAKASQAGQTALMLAVSHGRQEMVRALLDCGANVNIQDDEGSTALMCASEHGRAEIVSLLLEQPGCDISIVDNDGSNALSIALEASHNDIAVLLYAHMNYSKTQADASPK--ANSRSPSSPR 908

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Xenopus
Match: cnnm1 (cyclin and CBS domain divalent metal cation transport mediator 1 [Source:Xenbase;Acc:XB-GENE-989587])

HSP 1 Score: 94.7449 bits (234), Expect = 1.175e-18
Identity = 66/251 (26.29%), Postives = 126/251 (50.20%), Query Frame = 3

Query: 3777 IKPCLMLI--DWWVDMVIKLSSNQ--LLTTVQYLISTF---NKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAA--TLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKI-LSSNSNPISPRTFRKY 4499
            ++ CL  +  +W+     ++SS +  +   V+  I+ F   +   + +++   D  GNT +HY + H  ++   ++    + + N  N  G+T +MLAA   ++ P ++    + +L    D+N ++ + GQTA+ L+  H   + +  L A GAD+NI+D E +T LM A+   +++ VK +LA  G    L++ DG+SAL +A      +I+ +              Y+ +  S   +P +PR  RK+
Sbjct: 1102 VRLCLTTVQNEWF-----RVSSQKSAVAPMVEDYITAFKDLSPAVLSYIINMADGNGNTALHYSVSHSNFDIVKLLLDADVCNVNQQNKAGYTPIMLAALAAVEAPKDM--GVVEELFGSGDVNAKASQAGQTALMLAVSHGRIDMVRALLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQHGCNAALEDNDGSSALSIALDAGHKDIAVIL-------------YAHLNFSKTPSPGTPRLSRKF 1332

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Xenopus
Match: clasp1 (cytoplasmic linker associated protein 1 [Source:Xenbase;Acc:XB-GENE-6049805])

HSP 1 Score: 89.3521 bits (220), Expect = 3.761e-17
Identity = 54/186 (29.03%), Postives = 96/186 (51.61%), Query Frame = 3

Query: 3855 VQYLISTFNKNFVKFL--VIN-RDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFT 4403
            +++ ++ F     + L  +IN  D +GNT +HY +    + +   +  TGL D N  N  GFT +ML A      +     + ++    D+N ++ + GQTA+ L+  H   + +  L A GAD+NI+D + +T LM A    +   V  +LA P   + L + DG++AL +A +   ++I+ L +
Sbjct:  674 IRHHLTVFRAMSPRLLEVIINMADAKGNTAVHYAVSQSNFTAVRQLLDTGLCDVNRQNKAGFTPLMLTALAAFRSDEDIETVTQMLRLGDVNCRASQAGQTALMLAVSHGRLDVVRALLACGADVNIQDHDGSTALMCACEHGHADIVSLLLAVPACDVSLTDNDGSTALSIALEAGQNDIAMLLS 859

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Xenopus
Match: clasp1 (cytoplasmic linker associated protein 1 [Source:Xenbase;Acc:XB-GENE-6049805])

HSP 1 Score: 89.3521 bits (220), Expect = 4.089e-17
Identity = 54/186 (29.03%), Postives = 96/186 (51.61%), Query Frame = 3

Query: 3855 VQYLISTFNKNFVKFL--VIN-RDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFT 4403
            +++ ++ F     + L  +IN  D +GNT +HY +    + +   +  TGL D N  N  GFT +ML A      +     + ++    D+N ++ + GQTA+ L+  H   + +  L A GAD+NI+D + +T LM A    +   V  +LA P   + L + DG++AL +A +   ++I+ L +
Sbjct:  675 IRHHLTVFRAMSPRLLEVIINMADAKGNTAVHYAVSQSNFTAVRQLLDTGLCDVNRQNKAGFTPLMLTALAAFRSDEDIETVTQMLRLGDVNCRASQAGQTALMLAVSHGRLDVVRALLACGADVNIQDHDGSTALMCACEHGHADIVSLLLAVPACDVSLTDNDGSTALSIALEAGQNDIAMLLS 860

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Xenopus
Match: ENSXETT00000039221.1 (KN motif and ankyrin repeat domains 3 [Source:NCBI gene;Acc:100170188])

HSP 1 Score: 86.2705 bits (212), Expect = 3.367e-16
Identity = 49/162 (30.25%), Postives = 87/162 (53.70%), Query Frame = 3

Query: 3915 DQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF 4400
            D  GNT +HY + H  +    ++  TG+ + +  N  G+T +MLAA   V  E   N + +L    ++N ++ + GQTA+ L+  H     +  L A GA++N++D E +T LM A+     + VK +LA     + + + DG++AL +A +   ++I+ L 
Sbjct:  867 DGNGNTALHYSVSHSNFFIVQLLLDTGVCNVDRQNKAGYTAIMLAALAAVEKEDDMNVVSRLFSLGNVNAKASQAGQTALMLAVSHGRQEMVQALLACGANVNLQDDEGSTALMCASEHGRAEIVKLLLAQTDCDVSITDNDGSNALSIALEAGQNDIAMLL 1028

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Xenopus
Match: letmd1 (LETM1 domain containing 1 [Source:Xenbase;Acc:XB-GENE-962658])

HSP 1 Score: 64.6994 bits (156), Expect = 1.817e-11
Identity = 37/107 (34.58%), Postives = 59/107 (55.14%), Query Frame = 3

Query: 4107 KADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRS 4427
            + ++NL + +  QT++ L+  H   + +T L   GAD+N++D +  T LM+A    N+  VK +LA PG   EL +K GN+AL +   +  SEI+         RRS
Sbjct:   23 EGNVNLCATQGRQTSLMLAVSHGRLDMVTVLLNCGADVNLQDEDGETALMMACRLGNMDLVKLLLAQPGCDTELSDKVGNTALSIVLNSAHSEIAEFLQAHTEHRRS 129

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Mouse
Match: Kank3 (KN motif and ankyrin repeat domains 3 [Source:MGI Symbol;Acc:MGI:1098615])

HSP 1 Score: 99.7525 bits (247), Expect = 8.903e-21
Identity = 59/205 (28.78%), Postives = 106/205 (51.71%), Query Frame = 3

Query: 3789 LMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHI-RKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF 4400
            L+  +W+     K S  + +  V   + +     + ++V   D  GNT +HY + H      S++  TG+ D N  N  G++ +MLAA   V  E  +  + ++L    D+N ++ + GQTA+ L+  H + + +  L   GAD+N++D++  T LM A+    +  V+ +LA PG  L + + +G SAL +A +    E++AL 
Sbjct:  374 LVAQEWFRVSSQKRSQAESVAGVLRGVKSLGPELLAYVVNLADGNGNTALHYSVSHGNLAISSLLLDTGVCDVNHQNRAGYSALMLAALTSVGQEEEDMAVAQRLFSMGDVNAKASQTGQTALMLAISHGHQDMVAALLECGADVNVQDADGATALMCASEYGRLDTVQLLLAQPGCDLTILDNEGTSALAIALEAEQDEVAALL 578

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Mouse
Match: Kank3 (KN motif and ankyrin repeat domains 3 [Source:MGI Symbol;Acc:MGI:1098615])

HSP 1 Score: 99.7525 bits (247), Expect = 1.576e-20
Identity = 59/205 (28.78%), Postives = 106/205 (51.71%), Query Frame = 3

Query: 3789 LMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHI-RKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF 4400
            L+  +W+     K S  + +  V   + +     + ++V   D  GNT +HY + H      S++  TG+ D N  N  G++ +MLAA   V  E  +  + ++L    D+N ++ + GQTA+ L+  H + + +  L   GAD+N++D++  T LM A+    +  V+ +LA PG  L + + +G SAL +A +    E++AL 
Sbjct:  562 LVAQEWFRVSSQKRSQAESVAGVLRGVKSLGPELLAYVVNLADGNGNTALHYSVSHGNLAISSLLLDTGVCDVNHQNRAGYSALMLAALTSVGQEEEDMAVAQRLFSMGDVNAKASQTGQTALMLAISHGHQDMVAALLECGADVNVQDADGATALMCASEYGRLDTVQLLLAQPGCDLTILDNEGTSALAIALEAEQDEVAALL 766

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Mouse
Match: Kank4 (KN motif and ankyrin repeat domains 4 [Source:MGI Symbol;Acc:MGI:3043381])

HSP 1 Score: 89.3521 bits (220), Expect = 2.678e-17
Identity = 52/189 (27.51%), Postives = 101/189 (53.44%), Query Frame = 3

Query: 3801 DWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLA--ATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKL 4361
            +W+     KLSS + +      +   +   +K LV   D+ GNT +HY + H  +    ++  TG+ + +  N  G+T +M+   A+ +  +++    + KL  + ++N+Q+ + GQTA+ L   HD ++ +  L +  AD+N++D++ ++ LM+A  + N   V+ +LA P     L +K G +AL L
Sbjct:  798 EWFRVSSRKLSSPEAVAAYLLEVQPHSPYLLKLLVNLADRSGNTALHYSVSHSNFAIVKLLLDTGVCNVDHQNKAGYTAVMITPLASAETKEDMAV--VWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDNDGSSALMLACHQGNADLVRLLLAHPACNSSLTDKAGRTALSL 984

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Mouse
Match: Kank1 (KN motif and ankyrin repeat domains 1 [Source:MGI Symbol;Acc:MGI:2147707])

HSP 1 Score: 89.3521 bits (220), Expect = 3.598e-17
Identity = 59/205 (28.78%), Postives = 106/205 (51.71%), Query Frame = 3

Query: 3885 NFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKI-LSSNSNPISPRTFRK 4496
            + +++++   D  GNT +HY + H  ++   ++    + + +  N  G+T +MLAA   V  E     + +L    D+N ++ + GQTA+ L+  H   + +  L A GAD+NI+D E +T LM A+   +++ VK +LA PG    L++ DG++AL +A +    +I+ L              Y+ +  S   +P +PR  RK
Sbjct: 1157 DVLRYIINMADGNGNTALHYSVSHSNFQIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMQVVEELFSCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLL-------------YAHLNFSKAQSPSTPRLGRK 1348

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Mouse
Match: Kank2 (KN motif and ankyrin repeat domains 2 [Source:MGI Symbol;Acc:MGI:2384568])

HSP 1 Score: 85.5001 bits (210), Expect = 3.927e-16
Identity = 64/231 (27.71%), Postives = 118/231 (51.08%), Query Frame = 3

Query: 3795 LIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFL--VIN-RDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLA--ATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRS--EISGYSKILSSNS 4466
            ++  W+ +  +  ++  L  V+  + TF     + L  V+N  D  GNT +HY + H  +     +  +G+   +  N  G++ +ML   ATL+  D+I    I +L    ++N ++ + GQTA+ L+  H   + +  L A  AD+NI+D + +T LM A    + +    +LA P   + L ++DG++AL +A     SEI+++   R +I+ S   +S Y    SS++
Sbjct:  615 VLQEWLRLACRSDAHPEL--VRRHLVTFRAMSARLLDYVVNIADSNGNTALHYSVSHANFPVVRQLLDSGVCHVDKLNRAGYSPIMLTALATLKTQDDI--ETILQLFRLGNVNAKASQAGQTALMLAVSHGRVDVVRALLACEADVNIQDEDGSTALMCACEHGHKEITGLLLAVPSCDISLTDRDGSTALMVALDAGQSEIASMLYSRMNIKCSFAPMSDYESPASSSA 841

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. UniProt/SwissProt
Match: sp|Q9Z1P7|KANK3_MOUSE (KN motif and ankyrin repeat domain-containing protein 3 OS=Mus musculus OX=10090 GN=Kank3 PE=1 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 1.102e-19
Identity = 59/205 (28.78%), Postives = 106/205 (51.71%), Query Frame = 3

Query: 3789 LMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHI-RKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF 4400
            L+  +W+     K S  + +  V   + +     + ++V   D  GNT +HY + H      S++  TG+ D N  N  G++ +MLAA   V  E  +  + ++L    D+N ++ + GQTA+ L+  H + + +  L   GAD+N++D++  T LM A+    +  V+ +LA PG  L + + +G SAL +A +    E++AL 
Sbjct:  562 LVAQEWFRVSSQKRSQAESVAGVLRGVKSLGPELLAYVVNLADGNGNTALHYSVSHGNLAISSLLLDTGVCDVNHQNRAGYSALMLAALTSVGQEEEDMAVAQRLFSMGDVNAKASQTGQTALMLAISHGHQDMVAALLECGADVNVQDADGATALMCASEYGRLDTVQLLLAQPGCDLTILDNEGTSALAIALEAEQDEVAALL 766

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. UniProt/SwissProt
Match: sp|X1WE18|KANK2_DANRE (KN motif and ankyrin repeat domain-containing protein 2 OS=Danio rerio OX=7955 GN=kank2 PE=3 SV=1)

HSP 1 Score: 95.9005 bits (237), Expect = 2.156e-18
Identity = 52/203 (25.62%), Postives = 102/203 (50.25%), Query Frame = 3

Query: 3792 MLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF 4400
            +L +W      K +   ++       ++ +   ++F++   D  GNT +HY + H  +    ++  TGL + +  N  G+T +ML A      +     + +L    D+N ++ + GQTA+ L+  H   + +  L A GA +N+RD + +T LM A    ++  V+ +L+ PG    L + DG++AL +A + + ++I+ L 
Sbjct:  852 VLQEWLRVSCHKAADTAVVKAHMDAFASISPQLLEFVINMADGNGNTALHYTVSHSNFPVVKLLLDTGLCNADKQNKAGYTAIMLTALAAFSSDSDLQTVLQLLRTGDVNAKASQAGQTALMLAVSHGRGDMVKALLACGAQVNLRDDDGSTALMCACEHGHVDIVRQLLSVPGCDATLTDNDGSTALSIALEASQNDIAVLL 1054

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. UniProt/SwissProt
Match: sp|Q5T7N3|KANK4_HUMAN (KN motif and ankyrin repeat domain-containing protein 4 OS=Homo sapiens OX=9606 GN=KANK4 PE=1 SV=1)

HSP 1 Score: 93.5893 bits (231), Expect = 1.085e-17
Identity = 64/248 (25.81%), Postives = 127/248 (51.21%), Query Frame = 3

Query: 3717 WLNTSKLVSMNNIEHMPQ------EMIKPCLMLI--DWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLA--ATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLA-EQNNFSEISALFTQRRSIRRS 4427
            +LN  + +S    +H+P+      ++++  L  I  +W+     K SS  ++ +  + +   + +F+K LV   D  GNT +HY + H  +    ++  TG+ + +  N  G+T +M+   A+ +  +++    + KL  + ++N+Q+ + GQTA+ L   HD ++ +  L +  AD+N++D + ++ LM+A    N+  V+ +LA P     L +K G +AL +A +     EI+ L        RS
Sbjct:  751 FLNACRALS----QHLPETGTTTDQLLRQSLNTISQEWFRVSSRKSSSPAVVASYLHEVQPHSPHFLKLLVNLADHNGNTALHYSVSHSNFSIVKLLLETGVCNVDHQNKAGYTAVMITPLASAETNEDMAV--VWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDHDGSSALMVACHHGNVDLVRLLLAHPACDSSLTDKAGRTALSIALKSPTHMEIAGLLRAHAEQGRS 992

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. UniProt/SwissProt
Match: sp|Q6NY19|KANK3_HUMAN (KN motif and ankyrin repeat domain-containing protein 3 OS=Homo sapiens OX=9606 GN=KANK3 PE=1 SV=1)

HSP 1 Score: 90.8929 bits (224), Expect = 6.908e-17
Identity = 64/240 (26.67%), Postives = 117/240 (48.75%), Query Frame = 3

Query: 3789 LMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHI-RKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEI-SGYSKILSSNSNPISPRTFRKYT 4502
            L+  +W+     + S  + +  +   +       +  +V   D  GNT +HY + H      S++  TG  + N  N  G++ +MLAA   V  E  +  + ++L    D+N ++ + GQTA+ L+  H   + + TL A GAD+N +D++  T LM A+    +  V+ +L  PG    + + +G SAL +A +    E++AL     S  + +  +G  +   S+  P  PR F+K++
Sbjct:  578 LVAQEWFRVSSQRRSQAEPVARMLEGVRRLGPELLAHVVNLADGNGNTALHYSVSHGNLAIASLLLDTGACEVNRQNRAGYSALMLAALTSVRQEEEDMAVVQRLFCMGDVNAKASQTGQTALMLAISHGRQDMVATLLACGADVNAQDADGATALMCASEYGRLDTVRLLLTQPGCDPAILDNEGTSALAIALEAEQDEVAALLHAHLSSGQPDTQAGVQRHNLSSLQPPPPR-FKKFS 816

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. UniProt/SwissProt
Match: sp|Q6P9J5|KANK4_MOUSE (KN motif and ankyrin repeat domain-containing protein 4 OS=Mus musculus OX=10090 GN=Kank4 PE=1 SV=1)

HSP 1 Score: 89.3521 bits (220), Expect = 1.873e-16
Identity = 52/189 (27.51%), Postives = 101/189 (53.44%), Query Frame = 3

Query: 3801 DWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLA--ATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKL 4361
            +W+     KLSS + +      +   +   +K LV   D+ GNT +HY + H  +    ++  TG+ + +  N  G+T +M+   A+ +  +++    + KL  + ++N+Q+ + GQTA+ L   HD ++ +  L +  AD+N++D++ ++ LM+A  + N   V+ +LA P     L +K G +AL L
Sbjct:  798 EWFRVSSRKLSSPEAVAAYLLEVQPHSPYLLKLLVNLADRSGNTALHYSVSHSNFAIVKLLLDTGVCNVDHQNKAGYTAVMITPLASAETKEDMAV--VWKLLREGNVNIQATQGGQTALMLGVSHDREDMVQALLSCQADVNLQDNDGSSALMLACHQGNADLVRLLLAHPACNSSLTDKAGRTALSL 984

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. TrEMBL
Match: A0A0K8SHE3 (ANK_REP_REGION domain-containing protein OS=Lygus hesperus OX=30085 PE=4 SV=1)

HSP 1 Score: 110.538 bits (275), Expect = 1.785e-22
Identity = 69/228 (30.26%), Postives = 116/228 (50.88%), Query Frame = 3

Query: 3807 WVDMVIKLSSNQLLTTVQYLISTFNK---NFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNPISP 4481
            W  +    S+N L   V+Y +  F +     ++ +V   D  GNT MHY + +  ++  S++  + + + N  N  G+T +ML A  +V  E     +R+L   AD+N+++K+HGQTA+ L+  H   +T+  L   GADINI+D + +T LM A     I+ VK +LA P   L + + DG +AL +A +    ++  L   +    R   S Y+ +    S   +P
Sbjct:   48 WFKVSSVASANPL--DVEYYLDCFEEISGTLLEHVVNMSDVSGNTAMHYAVSNGNFDVVSILLDSKVCNINKLNTAGYTCIMLVALTKVKSETDREVVRRLFHMADVNIRAKQHGQTALMLAVSHGRIDTVELLLEAGADINIQDDDGSTALMCAAEHGYIEIVKLLLAQPDCDLSITDYDGTTALAIAMEAGNRDVGVLLYAQEHFSRGS-SPYTSLKHKRSKSTTP 272

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. TrEMBL
Match: A0A226DHA0 (KN motif and ankyrin repeat domain-containing protein 1 OS=Folsomia candida OX=158441 GN=Fcan01_21279 PE=4 SV=1)

HSP 1 Score: 116.316 bits (290), Expect = 3.095e-22
Identity = 62/199 (31.16%), Postives = 105/199 (52.76%), Query Frame = 3

Query: 3876 FNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNP 4472
            ++   ++++V   D  GNT +HY + H  ++  S++  + + DPN  N  G+T +ML A   +  E     +R+L    D+N+++ +HGQTA+ L A H   +TI  L   GADINI+D + +T LM A    ++K VK +LA P     + + DG++A  +A +    +I  L   +    R E +G     S ++ P
Sbjct:  760 YSPQLLRYIVNMPDGNGNTALHYAVSHGNFDVVSILLDSKVCDPNKANKAGYTSIMLVALANISCEAHRQVVRRLFSLGDVNIKAAQHGQTALMLGASHGRFDTIRLLLEAGADINIQDEDGSTALMCAAEHGHMKIVKYLLAHPDCNPHITDNDGSTAFSIAMEGQHKDIGVLLYAQMHFARPEGAGGLAAKSRSTTP 958

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. TrEMBL
Match: A0A2G9TL30 (Ankyrin repeat protein OS=Teladorsagia circumcincta OX=45464 GN=TELCIR_19983 PE=4 SV=1)

HSP 1 Score: 107.842 bits (268), Expect = 4.224e-22
Identity = 60/188 (31.91%), Postives = 100/188 (53.19%), Query Frame = 3

Query: 3867 ISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSE 4430
            I   +   +K +V   DQ GNT +HY + H  +   S +  +G    N+ N  G++ +MLAA   + +E+    +++L +  D+N ++++HGQTA+ LS  H    T   L A GAD+N++D E +T LM A    +   VK +L  PG+   L + D ++AL +A +N   +I  L     +  R+E
Sbjct:   49 IKALSPALLKVIVNITDQNGNTALHYAVSHGNFGVVSSLLDSGECQLNLANRAGYSAVMLAALSSLENEVEKAVVQRLFELGDVNARAQQHGQTALMLSVSHGKKATTDLLLACGADVNLQDEEGSTALMCAAEHGHKDIVKLLLGQPGIDAALTDCDSSTALSIAVENGHRDIGVLIYAHLNYSRAE 236

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. TrEMBL
Match: A0A1B6MJY1 (ANK_REP_REGION domain-containing protein (Fragment) OS=Graphocephala atropunctata OX=36148 GN=g.25556 PE=4 SV=1)

HSP 1 Score: 112.464 bits (280), Expect = 4.960e-22
Identity = 78/278 (28.06%), Postives = 139/278 (50.00%), Query Frame = 3

Query: 3708 VMLWLNTSKLVSMNNIEHMPQEMIKPCLMLIDWWVDMVIKLSSNQLLTTVQYL--ISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF----------TQRRSIRRSEISGYSKILSSNSNPISPRTFRKYTY 4505
             M  LN + L S N   + P +M     ++   W  +    S+N L     YL  +   +   ++++V   D  GNT MHY + H  ++  S++  + + + N  N  G+T +ML +  QV  E     +R+L   AD+N+++K+HGQTA+ L+  H   + +  L   GAD+NI+D + +T LM A   ++I+ VK +LA P   L +++ DG++AL +A +    +I  L           +   S+R       +  L + ++P  PRT + +++
Sbjct:  172 AMKVLNDALLKSPNG--NPPPQMKNAINIIQQEWFKISSTASANPL-DVEDYLDCLEEMSSRLLEYVVNMTDVSGNTAMHYAVSHGNFDVVSILLDSKVCNINQTNAAGYTCIMLVSLAQVRSETHRQVVRRLFQMADVNIRAKQHGQTALMLAVSHGGLDMVDLLLQSGADMNIQDEDGSTALMCAAEHHHIEIVKLLLAQPDCDLSIRDYDGSTALNIAMEAGNRDIGVLLYAQEHFSRGSSPHTSLRHRRAKSTTPTLRTPTSP-QPRTKQDHSF 445

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. TrEMBL
Match: A0A0A9WCW6 (KN motif and ankyrin repeat domain-containing protein 1 OS=Lygus hesperus OX=30085 GN=KANK1_0 PE=4 SV=1)

HSP 1 Score: 110.538 bits (275), Expect = 4.998e-22
Identity = 69/228 (30.26%), Postives = 116/228 (50.88%), Query Frame = 3

Query: 3807 WVDMVIKLSSNQLLTTVQYLISTFNK---NFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNPISP 4481
            W  +    S+N L   V+Y +  F +     ++ +V   D  GNT MHY + +  ++  S++  + + + N  N  G+T +ML A  +V  E     +R+L   AD+N+++K+HGQTA+ L+  H   +T+  L   GADINI+D + +T LM A     I+ VK +LA P   L + + DG +AL +A +    ++  L   +    R   S Y+ +    S   +P
Sbjct:   96 WFKVSSVASANPL--DVEYYLDCFEEISGTLLEHVVNMSDVSGNTAMHYAVSNGNFDVVSILLDSKVCNINKLNTAGYTCIMLVALTKVKSETDREVVRRLFHMADVNIRAKQHGQTALMLAVSHGRIDTVELLLEAGADINIQDDDGSTALMCAAEHGYIEIVKLLLAQPDCDLSITDYDGTTALAIAMEAGNRDVGVLLYAQEHFSRGS-SPYTSLKHKRSKSTTP 320

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Cavefish
Match: ENSAMXT00000041606.1 (KN motif and ankyrin repeat domain-containing protein 4-like [Source:NCBI gene;Acc:103044744])

HSP 1 Score: 102.449 bits (254), Expect = 1.692e-21
Identity = 59/185 (31.89%), Postives = 97/185 (52.43%), Query Frame = 3

Query: 3867 ISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIR 4421
            +S +    + FLV   D  GNT +HY + H  +    ++  TG+ + +  N  G+T MMLA  + V   +    I++L   +D+N ++ + GQTA++L+  H   +T+  L A GA+IN +D    T L+ A  + +   V+ +L  P   + L +K G SAL LA Q + +EI+ L   R   R
Sbjct:  597 VSKYTPAVLPFLVNMVDDNGNTALHYSVSHSNFRIAKILLDTGVCEVDKRNKIGYTAMMLACLVPVDSPVEMKAIQQLMKLSDVNARAGQVGQTALHLAVRHGRVSTVQLLLAQGANINAQDRAGTTALISACDRGHADIVRILLEDPDCDVNLTDKGGRSALSLATQASHTEIADLLRARAGTR 781

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Cavefish
Match: ENSAMXT00000019381.2 (KN motif and ankyrin repeat domain-containing protein 4-like [Source:NCBI gene;Acc:103044744])

HSP 1 Score: 102.449 bits (254), Expect = 2.016e-21
Identity = 59/185 (31.89%), Postives = 97/185 (52.43%), Query Frame = 3

Query: 3867 ISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIR 4421
            +S +    + FLV   D  GNT +HY + H  +    ++  TG+ + +  N  G+T MMLA  + V   +    I++L   +D+N ++ + GQTA++L+  H   +T+  L A GA+IN +D    T L+ A  + +   V+ +L  P   + L +K G SAL LA Q + +EI+ L   R   R
Sbjct:  732 VSKYTPAVLPFLVNMVDDNGNTALHYSVSHSNFRIAKILLDTGVCEVDKRNKIGYTAMMLACLVPVDSPVEMKAIQQLMKLSDVNARAGQVGQTALHLAVRHGRVSTVQLLLAQGANINAQDRAGTTALISACDRGHADIVRILLEDPDCDVNLTDKGGRSALSLATQASHTEIADLLRARAGTR 916

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Cavefish
Match: kank1a (KN motif and ankyrin repeat domains 1 [Source:NCBI gene;Acc:103041518])

HSP 1 Score: 96.6709 bits (239), Expect = 1.322e-19
Identity = 76/291 (26.12%), Postives = 147/291 (50.52%), Query Frame = 3

Query: 3690 FQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLI--DWWVDMVIKLSSNQ--LLTTVQYLISTF---NKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNV-----QGFTVMMLAA--TLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKI-LSSNSNPISPRTFRKYTYN*SR 4517
            +++S +++   N  K   +N+ +    + ++ C+  +  +W+     ++SS +  + T V+  ++ F   +   +K +V   D  GNT +HY + H    +F ++    L+D N+ NV      G+T +MLAA   ++ P ++    + +L  K D+N ++ + GQT + L+  H   + +  L A GAD+NI+D E +T LM A+   +++ VK +LA PG    L + D ++AL +A +    +I+ L              Y+ +  S   +P +PR  RK + + +R
Sbjct:  857 YELSEKMLAACNVVK-AHLNDPKSSSGKEVRMCMNTVQHEWF-----RVSSQKTAVATMVEDYLNAFRNISPALLKHVVNLADGNGNTALHYSVSHS---NFHIVKK--LLDANVCNVNQQNKAGYTPIMLAALAAVEAPKDM--RVVEELFSKGDVNSKASQAGQTGLMLAVSHGRMDMVKALLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCDATLSDNDESTALSIALEAGHKDIAVLL-------------YAHVNFSKAQSPGTPRLGRKTSPSPTR 1121

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Cavefish
Match: kank1a (KN motif and ankyrin repeat domains 1 [Source:NCBI gene;Acc:103041518])

HSP 1 Score: 96.6709 bits (239), Expect = 1.441e-19
Identity = 76/291 (26.12%), Postives = 147/291 (50.52%), Query Frame = 3

Query: 3690 FQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLI--DWWVDMVIKLSSNQ--LLTTVQYLISTF---NKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNV-----QGFTVMMLAA--TLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKI-LSSNSNPISPRTFRKYTYN*SR 4517
            +++S +++   N  K   +N+ +    + ++ C+  +  +W+     ++SS +  + T V+  ++ F   +   +K +V   D  GNT +HY + H    +F ++    L+D N+ NV      G+T +MLAA   ++ P ++    + +L  K D+N ++ + GQT + L+  H   + +  L A GAD+NI+D E +T LM A+   +++ VK +LA PG    L + D ++AL +A +    +I+ L              Y+ +  S   +P +PR  RK + + +R
Sbjct: 1058 YELSEKMLAACNVVK-AHLNDPKSSSGKEVRMCMNTVQHEWF-----RVSSQKTAVATMVEDYLNAFRNISPALLKHVVNLADGNGNTALHYSVSH---SNFHIVKK--LLDANVCNVNQQNKAGYTPIMLAALAAVEAPKDM--RVVEELFSKGDVNSKASQAGQTGLMLAVSHGRMDMVKALLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCDATLSDNDESTALSIALEAGHKDIAVLL-------------YAHVNFSKAQSPGTPRLGRKTSPSPTR 1322

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Cavefish
Match: kank1a (KN motif and ankyrin repeat domains 1 [Source:NCBI gene;Acc:103041518])

HSP 1 Score: 96.6709 bits (239), Expect = 1.527e-19
Identity = 76/291 (26.12%), Postives = 147/291 (50.52%), Query Frame = 3

Query: 3690 FQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLI--DWWVDMVIKLSSNQ--LLTTVQYLISTF---NKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNV-----QGFTVMMLAA--TLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKI-LSSNSNPISPRTFRKYTYN*SR 4517
            +++S +++   N  K   +N+ +    + ++ C+  +  +W+     ++SS +  + T V+  ++ F   +   +K +V   D  GNT +HY + H    +F ++    L+D N+ NV      G+T +MLAA   ++ P ++    + +L  K D+N ++ + GQT + L+  H   + +  L A GAD+NI+D E +T LM A+   +++ VK +LA PG    L + D ++AL +A +    +I+ L              Y+ +  S   +P +PR  RK + + +R
Sbjct: 1054 YELSEKMLAACNVVK-AHLNDPKSSSGKEVRMCMNTVQHEWF-----RVSSQKTAVATMVEDYLNAFRNISPALLKHVVNLADGNGNTALHYSVSH---SNFHIVKK--LLDANVCNVNQQNKAGYTPIMLAALAAVEAPKDM--RVVEELFSKGDVNSKASQAGQTGLMLAVSHGRMDMVKALLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCDATLSDNDESTALSIALEAGHKDIAVLL-------------YAHVNFSKAQSPGTPRLGRKTSPSPTR 1318

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003964.1 (pep scaffold:Pmarinus_7.0:GL481009:348:11102:1 gene:ENSPMAG00000003629.1 transcript:ENSPMAT00000003964.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 90.8929 bits (224), Expect = 1.155e-18
Identity = 48/162 (29.63%), Postives = 88/162 (54.32%), Query Frame = 3

Query: 3915 DQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF 4400
            D  GNT +HY + H  +    ++  TG  + +  N  G+T +MLA+   +  E     ++KL    D+N ++ + GQTA+ L+  H   + +  L A GAD+N++D + +T LM A+   ++  V+ +LA  G    + + DG++AL +A +   ++I+ L 
Sbjct:  508 DGNGNTALHYSVSHSNFAIVQMLLGTGECNVDAQNKAGYTAIMLASLAAINSERDMAVVQKLLSLGDVNARASQAGQTALMLAVSHGRKDMVRALLACGADVNVQDDDGSTALMCASEHGHVDIVRLLLAQAGCNAAIADNDGSTALSIALEAGHNDIAVLL 669

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004707.1 (pep scaffold:Pmarinus_7.0:GL480522:11184:13485:1 gene:ENSPMAG00000004287.1 transcript:ENSPMAT00000004707.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 45.8246 bits (107), Expect = 6.598e-6
Identity = 29/110 (26.36%), Postives = 53/110 (48.18%), Query Frame = 3

Query: 4110 ADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISG 4439
            A +   +  + QT  +++A   + + +  L  +GA++N +D    TPL  A    + + V  ++AC G  +E+ N  G + L+LA    FS  +A      + RR +  G
Sbjct:   13 ASVTTVTSRYAQTPAHIAAFGGHQHCLLWLLRVGANVNQQDYLGETPLHKAARSGSEECVHLLVAC-GAQVEVPNHSGITPLELAISQGFSRPAAFLANELARRRGDAGG 121

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Nematostella
Match: EDO36063 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SJL9])

HSP 1 Score: 90.5077 bits (223), Expect = 6.516e-20
Identity = 48/162 (29.63%), Postives = 87/162 (53.70%), Query Frame = 3

Query: 3915 DQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF 4400
            D +GN  +HY + ++ W+  +V+  TG VD N+ N  G++ +MLAA      +   N  R+L    D+N +  E GQT + L+      + +  L    AD+N +D+E +T +M A+   +    + +LA P     +++ +G+SA+ +A + NF +I+ L 
Sbjct:   78 DAEGNNALHYAVTYRNWKVVNVLLNTGCVDVNLVNKAGYSSVMLAAVTGCQKDQYRNVARRLFQMGDVNKRYDETGQTPLMLAVSRGRLDMVDLLLETDADVNAQDNEGSTAIMCASEHGHTNIARRLLAQPHCDSSIEDNEGSSAMSIAMERNFKDIAVLI 239

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Nematostella
Match: EDO37330 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SG44])

HSP 1 Score: 50.447 bits (119), Expect = 7.157e-6
Identity = 32/96 (33.33%), Postives = 56/96 (58.33%), Query Frame = 3

Query: 4080 NNHIRKLADK-ADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLA 4364
            +N ++ L D+ AD+N Q+ E G TA+ +++   +   +  L   GAD N+++ E+ TPL  AT++     V+ +L   G  + +KN  G SAL++A
Sbjct:  705 DNEVKALIDEGADVNFQN-ELGHTALMVASREGHLKVVDELMVGGADPNLQEKEKRTPLQYATLRGKKLVVQTLLQY-GADITIKNTVGESALEIA 798

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Medaka
Match: ENSORLT00000046848.1 (KN motif and ankyrin repeat domain-containing protein 4 [Source:NCBI gene;Acc:105356192])

HSP 1 Score: 108.227 bits (269), Expect = 2.732e-23
Identity = 69/228 (30.26%), Postives = 114/228 (50.00%), Query Frame = 3

Query: 3744 MNNIEHMPQEMIKPCLMLIDWWVDMVIKLSSNQL-LTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILN-NHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIR 4421
            M N+++  ++M K  + L   W     + +S    +      +     + + FLV   D  GNT +HY + H  +   S++  TG+ D N+ N  G+T +MLA +L  PD       +RKL +  +LN++S + GQTA++L+  H  D  +  L + GAD NI+D++  T LM A  K +    + +L      L L +K G +AL +A Q + S+ +AL       R
Sbjct:  597 MGNMDNPSEDMRKALVTLFQHWFTTAAEEASEACNVAACVRGVKKETPSLLAFLVNLPDDNGNTVLHYSVSHCNYSIVSLLLDTGVADVNVQNKAGYTAVMLA-SLTAPDGPDGMETVRKLMELGNLNVRSSQTGQTALHLAVRHGRDIMVRLLLSCGADTNIQDNQGTTALMFAAEKGHTHVARLLLERSQSDLTLTDKRGRTALSIALQGSHSDTAALLQAHAKAR 823

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Medaka
Match: kank1a (KN motif and ankyrin repeat domains 1 [Source:NCBI gene;Acc:101162911])

HSP 1 Score: 100.523 bits (249), Expect = 1.024e-20
Identity = 61/214 (28.50%), Postives = 111/214 (51.87%), Query Frame = 3

Query: 3888 FVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLA--ATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKI-LSSNSNPISPRTFRKYTYN*SRN 4520
             ++++V   D  GNT +HY + H  ++    +    + + N  N  G+T +MLA  A ++ P ++  + + +L  K D+N ++ + GQT + L+  H   + +  L A GAD+N++D E +T LM A+   +++ VK +LA PG    L + DG+SAL +A +    +I+ L              Y+ +  S   +P +PR  RK + + +R 
Sbjct: 1008 VLRYIVNMADGNGNTALHYSVSHSNFQVVKTLLDADVCNVNQQNKAGYTPIMLAALAAVETPKDM--SVVEELFGKGDVNARASQAGQTGLMLAVSHGRMDMVRALLAHGADVNVQDDEGSTALMCASEHGHVEIVKLLLAQPGCDATLSDGDGSSALSIALEAGHKDIAVLL-------------YAHVNFSKAQSPGTPRLSRKASPSPTRR 1206

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Medaka
Match: kank1b (KN motif and ankyrin repeat domain-containing protein 1-like [Source:NCBI gene;Acc:101174279])

HSP 1 Score: 98.2117 bits (243), Expect = 5.334e-20
Identity = 58/177 (32.77%), Postives = 93/177 (52.54%), Query Frame = 3

Query: 3915 DQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAA--TLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISG 4439
            D  GNT +HY + H  +E    +   G+ + N+ N  G+T +MLAA   ++ PD +    + KL    ++N ++ + GQTA+ L+  H   + + TL A GAD+NIRD E +T LM A+       VK +LA P     L + D ++AL +A +   S+I+ L     +  R   +G
Sbjct: 1053 DGSGNTALHYSLSHSNFEVVKKLLDAGVCNVNLQNAAGYTPIMLAALSAVENPDHM--RVVEKLFAAGNVNAKASQAGQTALMLAVSHGRRDMVETLLAQGADVNIRDDEGSTALMCASEHGYADIVKLLLAQPECDATLTDSDESTALSIALEAGHSDIAVLLYAHTTFSRQTGAG 1227

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Medaka
Match: kank3 (KN motif and ankyrin repeat domains 3 [Source:NCBI gene;Acc:101163478])

HSP 1 Score: 97.0561 bits (240), Expect = 1.109e-19
Identity = 72/262 (27.48%), Postives = 126/262 (48.09%), Query Frame = 3

Query: 3771 EMIKPCLMLIDWWVDMVIKLSSNQLLT---TVQ-------------------YLI--STFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISA-LFTQRRSIRRSEISGYSKILSSNSNPISP 4481
            +M + CL+L +   D V  L S ++L+   TVQ                   YL+  S  +   ++ +V   D  GNT +HY + H  +    ++  TG+   +  N  G+T +MLAA   V +E     +RKL  + ++N ++ + GQTA+ L+  H     +  L   GAD+N++D E +T LM A+     + VK +L  PG  + + + DG++AL +A +   ++ +  L+      +   ++G  K  S   +P SP
Sbjct:  714 KMREACLILKNHLNDDVKTLKSKEVLSSTHTVQLEWFRISSAKTAQPSRVSDYLMAFSEVSSALLEHVVNMTDGNGNTALHYSVSHSNFHVVRLLLDTGVCCVDKQNKAGYTAIMLAALSTVKEEEDMAVVRKLFSQGNVNAKASQAGQTALMLAVSHGRQEMVRALLECGADVNVQDDEGSTALMCASEHGRAEIVKLLLEQPGCDISIVDNDGSNALSIALEAAHNDTAVLLYAHMNYAKAPSVAGSPK--SQARSPTSP 973

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Medaka
Match: kank2 (KN motif and ankyrin repeat domains 2 [Source:NCBI gene;Acc:101159267])

HSP 1 Score: 90.5077 bits (223), Expect = 1.032e-17
Identity = 51/203 (25.12%), Postives = 101/203 (49.75%), Query Frame = 3

Query: 3792 MLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALF 4400
            +L +W      K +   ++       ++ +   ++F++   D  GNT +HY + H  +    ++  T L + +  N  G+T +ML A      +     + +L    D+N ++ + GQTA+ L+  H   + +  L + GA +NIRD + +T LM A    ++  V+ +L+ PG    L + DG++AL +A + + ++I+ L 
Sbjct:  788 VLQEWLRVSCHKAADTSVVKAYMDTFASLSPQLLEFVINMADGNGNTALHYTVSHSNFPVVKLLLDT-LCNADKQNKAGYTAIMLTALAAFHSDSDLQTVLQLLRTGDVNAKASQAGQTALMLAVSHGRGDMVRALLSCGAQVNIRDDDGSTALMCACEHGHVDIVRQLLSVPGCDATLTDNDGSTALSIALEASQNDIAVLL 989

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Planmine SMEST
Match: SMESG000059500.1 (SMESG000059500.1)

HSP 1 Score: 2748 bits (7122), Expect = 0.000e+0
Identity = 1483/1484 (99.93%), Postives = 1484/1484 (100.00%), Query Frame = 3

Query:   57 MLKSEDKRTNNKKMSQPRQNSNSYMTREYSVRSQITNEMLANDNKYLNNEPESQWGINLINNSETLPTRFINRNLPTSLNRASNLNSMTTSSINYQMNEPDLQWKNNNNRFESRLMTDLPSPMSGVHNLASATMSPNINDNRDQFSIYGSFKKHISEKRDSSMKYDSTQVIETREINYKNLPVKQSTASYTSSEFEVPVNSALTSSGFFTPQTRSQQYTLQDILNSDATDSIKNQIVEDVPIKAETQNQNQNFSSLPEIVVETPKNEIASKDQEIKKLNKTIDKLNNKMKTLLQSNEEMKTHLKNLLNERKNLIKQXXXXXXXXXXXXXXVQRAKPNIATNVIPSQQKSTVIKQELIKENYLEKSKISLQDLPQHILNKYRQEIIDCERDKIELEKRTLINTLNIQYQQQLQSLRHEQDIRKTQMKHVSIQSYKTKKFNQTVSEVNLSRSTPPPKSIGTVFQPATFSKQSQNDIKDETNKKLAKDLDIHFTNYIRRRQIKTTEWQNTILQQLTESLDKNNSEQFMNIIEEILFKSSKNILTSVQPTVSSKLSQNEAIEDGNKSLSREVSKSLNEYIRSIKMKLSDWQKIMLERFLKSLEMNDVDNLSSVIEEILLKQMKSVETLSQPATVSRLSQNDSSEDSNSKLANEAFTLFXXXXXXXXXXXXKWQESIVERLMNSLKTNNSQMLSTVMEELLFKPSRTIGINSVPDNMNKNSQTQQKNYSNLSHEVNIVEEKPKFERLSKSVSAKPTTFQKGIQPDEKFFFETGTMTDHLFFRSQGVNTLTDYSKNLNSPYSETDSFVTRTSSRNESKKEIKSHTVIQSSSSNXXXXXXXXXXXXXXXIEPQNKNITEEWNQTFLVKELKGSNQNVSTTLDNIKSEVKEETIIKAQNKTQETASKPRXXXXXXXXXXXXKVQVMTAHVDKNQNIKDDTQTTVECWETISKIKDGKLIEKKECYRDKYVSSNPDEIRKHLXXXXXXXXXXXFEDKNDSGKSVETXXXXXXXXXXXXXXXXTLSNYGNSRLNTKTSSSSFNVPVIKGFEETEISKFRNYTNLGVSRKEVSSIVEQLSNSQLKENHSISERIEQSSTSKXXXXXXXXXXXXXXXXXDKSNYEPANQRKIDILSRSSKPKVLPKPITIQNSESLRSSQGINVNLKTFSPTIESSEMYFDETENSTVIGSDNSAFYSISELXXXXXXXXXXXXXEVLLPENIFQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNPISPRTFRKYTYN 4508
            MLKSEDKRTNNKKMSQPRQNSNSYMTREYSVRSQITNEMLANDNKYLNNEPESQWGINLINNSETLPTRFINRNLPTSLNRASNLNSMTTSSINYQMNEPDLQWKNNNNRFESRLMTDLPSPMSGVHNLASATMSPNINDNRDQFSIYGSFKKHISEKRDSSMKYDSTQVIETREINYKNLPVKQSTASYTSSEFEVPVNSALTSSGFFTPQTRSQQYTLQDILNSDATDSIKNQIVEDVPIKAETQNQNQNFSSLPEIVVETPKNEIASKDQEIKKLNKTIDKLNNKMKTLLQSNEEMKTHLKNLLNERKNLIKQIENSEFEEIIEEEEVQRAKPNIATNVIPSQQKSTVIKQELIKENYLEKSKISLQDLPQHILNKYRQEIIDCERDKIELEKRTLINTLNIQYQQQLQSLRHEQDIRKTQMKHVSIQSYKTKKFNQTVSEVNLSRSTPPPKSIGTVFQPATFSKQSQNDIKDETNKKLAKDLDIHFTNYIRRRQIKTTEWQNTILQQLTESLDKNNSEQFMNIIEEILFKSSKNILTSVQPTVSSKLSQNEAIEDGNKSLSREVSKSLNEYIRSIKMKLSDWQKIMLERFLKSLEMNDVDNLSSVIEEILLKQMKSVETLSQPATVSRLSQNDSSEDSNSKLANEAFTLFTTTMRSSRVTTTKWQESIVERLMNSLKTNNSQMLSTVMEELLFKPSRTIGINSVPDNMNKNSQTQQKNYSNLSHEVNIVEEKPKFERLSKSVSAKPTTFQKGIQPDEKFFFETGTMTDHLFFRSQGVNTLTDYSKNLNSPYSETDSFVTRTSSRNESKKEIKSHTVIQSSSSNLLKQHQKLQEKLEIKIEPQNKNITEEWNQTFLVKELKGSNQNVSTTLDNIKSEVKEETIIKAQNKTQETASKPRELIEEWEQNIEEKVQVMTAHVDKNQNIKDDTQTTVECWETISKIKDGKLIEKKECYRDKYVSSNPDEIRKHLESHEHNHSHSNFEDKNDSGKSVETHKHFHQNEEHNEHQKNTLSNYGNSRLNTKTSSSSFNVPVIKGFEETEISKFRNYTNLGVSRKEVSSIVEQLSNSQLKENHSISERIEQSSTSKSFNSPISFTSFSSISTNDKSNYEPANQRKIDILSRSSKPKVLPKPITIQNSESLRSSQGINVNLKTFSPTIESSEMYFDETENSTVIGSDNSAFYSISELPKPKKDDQKYDYQEVLLPENIFQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYL+ALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNPISPRTFRKYTYN
Sbjct:    1 MLKSEDKRTNNKKMSQPRQNSNSYMTREYSVRSQITNEMLANDNKYLNNEPESQWGINLINNSETLPTRFINRNLPTSLNRASNLNSMTTSSINYQMNEPDLQWKNNNNRFESRLMTDLPSPMSGVHNLASATMSPNINDNRDQFSIYGSFKKHISEKRDSSMKYDSTQVIETREINYKNLPVKQSTASYTSSEFEVPVNSALTSSGFFTPQTRSQQYTLQDILNSDATDSIKNQIVEDVPIKAETQNQNQNFSSLPEIVVETPKNEIASKDQEIKKLNKTIDKLNNKMKTLLQSNEEMKTHLKNLLNERKNLIKQIENSEFEEIIEEEEVQRAKPNIATNVIPSQQKSTVIKQELIKENYLEKSKISLQDLPQHILNKYRQEIIDCERDKIELEKRTLINTLNIQYQQQLQSLRHEQDIRKTQMKHVSIQSYKTKKFNQTVSEVNLSRSTPPPKSIGTVFQPATFSKQSQNDIKDETNKKLAKDLDIHFTNYIRRRQIKTTEWQNTILQQLTESLDKNNSEQFMNIIEEILFKSSKNILTSVQPTVSSKLSQNEAIEDGNKSLSREVSKSLNEYIRSIKMKLSDWQKIMLERFLKSLEMNDVDNLSSVIEEILLKQMKSVETLSQPATVSRLSQNDSSEDSNSKLANEAFTLFTTTMRSSRVTTTKWQESIVERLMNSLKTNNSQMLSTVMEELLFKPSRTIGINSVPDNMNKNSQTQQKNYSNLSHEVNIVEEKPKFERLSKSVSAKPTTFQKGIQPDEKFFFETGTMTDHLFFRSQGVNTLTDYSKNLNSPYSETDSFVTRTSSRNESKKEIKSHTVIQSSSSNLLKQHQKLQEKLEIKIEPQNKNITEEWNQTFLVKELKGSNQNVSTTLDNIKSEVKEETIIKAQNKTQETASKPRELIEEWEQNIEEKVQVMTAHVDKNQNIKDDTQTTVECWETISKIKDGKLIEKKECYRDKYVSSNPDEIRKHLESHEHNHSHSNFEDKNDSGKSVETHKHFHQNEEHNEHQKNTLSNYGNSRLNTKTSSSSFNVPVIKGFEETEISKFRNYTNLGVSRKEVSSIVEQLSNSQLKENHSISERIEQSSTSKSFNSPISFTSFSSISTNDKSNYEPANQRKIDILSRSSKPKVLPKPITIQNSESLRSSQGINVNLKTFSPTIESSEMYFDETENSTVIGSDNSAFYSISELPKPKKDDQKYDYQEVLLPENIFQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLAALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRRSEISGYSKILSSNSNPISPRTFRKYTYN 1484

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Planmine SMEST
Match: SMESG000043522.1 (SMESG000043522.1)

HSP 1 Score: 93.2041 bits (230), Expect = 1.234e-18
Identity = 64/251 (25.50%), Postives = 124/251 (49.40%), Query Frame = 3

Query: 3675 LPENIFQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQS-KEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQRRSIRR 4424
             PE I +    V +W+N S            +++ +   ++ ++W ++    SS+ +    ++  S+FN    + ++   D  GNTC+HY +    W    ++  T  V+ N  N  G+TV+ML A  +  DE     ++ L D ++++ QS  +  QTA+ ++A       +  L   G+ +NI D + +T LM A    +++ VK +L  P    EL++  G++A+K+A  N+  +I+ L   R ++ +
Sbjct:  761 FPEKIQEACELVAVWMNDSTTTC-------SKDLNESLAIIRNFWFEVTSDNSSDIMFYIKKF--SSFNPTLQERIINMTDSNGNTCLHYAVSEGRWSIVRLLLQTQQVNVNKTNNAGYTVLMLVAVSESIDE---ESLKMLIDASEIDKQSLNDTQQTALMIAASQGKTKLVQLLLEKGSSVNITDGDGSTALMCACDNGHLEVVKLLLTRPETDTELEDNTGSNAMKIALDNSHKDIALLIFARNNLHK 999

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Planmine SMEST
Match: SMESG000017281.1 (SMESG000017281.1)

HSP 1 Score: 55.0694 bits (131), Expect = 5.553e-7
Identity = 59/224 (26.34%), Postives = 106/224 (47.32%), Query Frame = 3

Query: 3762 MPQEMIKPCLMLIDWWVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINR-------DQQGNTCMHYIIGHQFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNS----ALKLAEQNNFSEISALF 4400
            +P+  IK C +LI+   D  +   +N  +T +    S+ +    + L  +R       D   +T +H  +      S  ++   G  D N  N + F    LAA LQ   +IL   +++   K  +    KE    AI+L AL+++++ +  L A  ADINIR++   T L IA ++ ++  VK IL      + L++ DG++    A+K+ +   F ++  +F
Sbjct:  497 VPKNQIKICDLLINKGAD--VNAQNNNKITPIMLAASSGSVEITRLLATSRNADLSIGDSDNDTALHLAVRKSRVNSVEILLDAG-ADINALNKKLFNGFHLAA-LQGHAKILELFLKREGVK--IVDSQKEDKFAAIHLVALNNHEDCLRVLLAYKADINIRNNILQTALHIAVLQKHLNCVK-ILVENYAEINLRDSDGDTPLHIAMKVKQIEAFKKMGRMF 713

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Planmine SMEST
Match: SMESG000030607.1 (SMESG000030607.1)

HSP 1 Score: 52.7582 bits (125), Expect = 2.926e-6
Identity = 33/95 (34.74%), Postives = 53/95 (55.79%), Query Frame = 3

Query: 4071 EILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSAL 4355
            EI+   I+   D+ D+NL+  + G  A++ +AL D+   I  L   GADIN R+    TPL IA  K +++ +KA+L     L   ++ DG++ L
Sbjct:  582 EIVQALIKYGGDQLDINLKDPD-GDAAVHHAALGDHKIIIQILKNAGADINSRNRRNQTPLHIAVNKGHLEVLKALLELKSALQTNQDYDGDTPL 675

[Close]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Planmine SMEST
Match: SMESG000030607.1 (SMESG000030607.1)

HSP 1 Score: 52.373 bits (124), Expect = 3.265e-6
Identity = 34/95 (35.79%), Postives = 54/95 (56.84%), Query Frame = 3

Query: 4071 EILNNHIRKLADKADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLMIATIKNNIKAVKAILACPGVLLELKNKDGNSAL 4355
            EI+   I+   D+ D+NL+  + G  A++ +AL D+   I  L   GADIN R+    TPL IA  K +++ +KA+L     L  L++ DG++ L
Sbjct:  582 EIVQALIKYGGDQLDINLKDPD-GDAAVHHAALGDHKIIIQILKNAGADINSRNRRNQTPLHIAVNKGHLEVLKALLELK-CLASLQDYDGDTPL 674

The following BLAST results are available for this feature:

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Human
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Celegans
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Fly
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Zebrafish
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Xenopus
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Mouse
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. UniProt/SwissProt
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. TrEMBL
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Cavefish
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Sea Lamprey
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Yeast
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Nematostella
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Medaka
BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Planmine SMEST

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
KANK4	1.738e-19	25.81	KN motif and ankyrin repeat domains 4 [Source:HGNC...	[more]
KANK4	1.876e-19	25.81	KN motif and ankyrin repeat domains 4 [Source:HGNC...	[more]
KANK4	2.259e-18	25.81	KN motif and ankyrin repeat domains 4 [Source:HGNC...	[more]
KANK3	1.439e-17	26.67	KN motif and ankyrin repeat domains 3 [Source:HGNC...	[more]
KANK1	1.470e-17	28.43	KN motif and ankyrin repeat domains 1 [Source:HGNC...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
vab-19	2.201e-19	32.26	VAB-19 [Source:UniProtKB/TrEMBL;Acc:G5EDN8]	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Kank	3.752e-21	28.08	gene:FBgn0027596 transcript:FBtr0303758	[more]
Kank	1.872e-19	29.12	gene:FBgn0027596 transcript:FBtr0087429	[more]
Kank	2.572e-19	29.12	gene:FBgn0027596 transcript:FBtr0112929	[more]
Kank	2.631e-19	29.12	gene:FBgn0027596 transcript:FBtr0332856	[more]
Kank	2.762e-19	29.12	gene:FBgn0027596 transcript:FBtr0303756	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
kank1b	3.465e-20	26.64	KN motif and ankyrin repeat domains 1b [Source:ZFI...	[more]
kank3	3.726e-20	27.27	KN motif and ankyrin repeat domains 3 [Source:ZFIN...	[more]
kank1a	2.369e-19	24.20	KN motif and ankyrin repeat domains 1a [Source:ZFI...	[more]
kank1a	2.614e-19	24.20	KN motif and ankyrin repeat domains 1a [Source:ZFI...	[more]
kank3	2.772e-19	27.27	KN motif and ankyrin repeat domains 3 [Source:ZFIN...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cnnm1	1.175e-18	26.29	cyclin and CBS domain divalent metal cation transp...	[more]
clasp1	3.761e-17	29.03	cytoplasmic linker associated protein 1 [Source:Xe...	[more]
clasp1	4.089e-17	29.03	cytoplasmic linker associated protein 1 [Source:Xe...	[more]
ENSXETT00000039221.1	3.367e-16	30.25	KN motif and ankyrin repeat domains 3 [Source:NCBI...	[more]
letmd1	1.817e-11	34.58	LETM1 domain containing 1 [Source:Xenbase;Acc:XB-G...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Kank3	8.903e-21	28.78	KN motif and ankyrin repeat domains 3 [Source:MGI ...	[more]
Kank3	1.576e-20	28.78	KN motif and ankyrin repeat domains 3 [Source:MGI ...	[more]
Kank4	2.678e-17	27.51	KN motif and ankyrin repeat domains 4 [Source:MGI ...	[more]
Kank1	3.598e-17	28.78	KN motif and ankyrin repeat domains 1 [Source:MGI ...	[more]
Kank2	3.927e-16	27.71	KN motif and ankyrin repeat domains 2 [Source:MGI ...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9Z1P7\|KANK3_MOUSE	1.102e-19	28.78	KN motif and ankyrin repeat domain-containing prot...	[more]
sp\|X1WE18\|KANK2_DANRE	2.156e-18	25.62	KN motif and ankyrin repeat domain-containing prot...	[more]
sp\|Q5T7N3\|KANK4_HUMAN	1.085e-17	25.81	KN motif and ankyrin repeat domain-containing prot...	[more]
sp\|Q6NY19\|KANK3_HUMAN	6.908e-17	26.67	KN motif and ankyrin repeat domain-containing prot...	[more]
sp\|Q6P9J5\|KANK4_MOUSE	1.873e-16	27.51	KN motif and ankyrin repeat domain-containing prot...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A0K8SHE3	1.785e-22	30.26	ANK_REP_REGION domain-containing protein OS=Lygus ...	[more]
A0A226DHA0	3.095e-22	31.16	KN motif and ankyrin repeat domain-containing prot...	[more]
A0A2G9TL30	4.224e-22	31.91	Ankyrin repeat protein OS=Teladorsagia circumcinct...	[more]
A0A1B6MJY1	4.960e-22	28.06	ANK_REP_REGION domain-containing protein (Fragment...	[more]
A0A0A9WCW6	4.998e-22	30.26	KN motif and ankyrin repeat domain-containing prot...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000041606.1	1.692e-21	31.89	KN motif and ankyrin repeat domain-containing prot...	[more]
ENSAMXT00000019381.2	2.016e-21	31.89	KN motif and ankyrin repeat domain-containing prot...	[more]
kank1a	1.322e-19	26.12	KN motif and ankyrin repeat domains 1 [Source:NCBI...	[more]
kank1a	1.441e-19	26.12	KN motif and ankyrin repeat domains 1 [Source:NCBI...	[more]
kank1a	1.527e-19	26.12	KN motif and ankyrin repeat domains 1 [Source:NCBI...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000003964.1	1.155e-18	29.63	pep scaffold:Pmarinus_7.0:GL481009:348:11102:1 gen...	[more]
ENSPMAT00000004707.1	6.598e-6	26.36	pep scaffold:Pmarinus_7.0:GL480522:11184:13485:1 g...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO36063	6.516e-20	29.63	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37330	7.157e-6	33.33	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSORLT00000046848.1	2.732e-23	30.26	KN motif and ankyrin repeat domain-containing prot...	[more]
kank1a	1.024e-20	28.50	KN motif and ankyrin repeat domains 1 [Source:NCBI...	[more]
kank1b	5.334e-20	32.77	KN motif and ankyrin repeat domain-containing prot...	[more]
kank3	1.109e-19	27.48	KN motif and ankyrin repeat domains 3 [Source:NCBI...	[more]
kank2	1.032e-17	25.12	KN motif and ankyrin repeat domains 2 [Source:NCBI...	[more]

BLAST of KN motif and ankyrin repeat domain-containing protein 4 isoform X2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000059500.1	0.000e+0	99.93	SMESG000059500.1	[more]
SMESG000043522.1	1.234e-18	25.50	SMESG000043522.1	[more]
SMESG000017281.1	5.553e-7	26.34	SMESG000017281.1	[more]
SMESG000030607.1	2.926e-6	34.74	SMESG000030607.1	[more]
SMESG000030607.1	3.265e-6	35.79	SMESG000030607.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30029492 ID=SMED30029492|Name=KN motif and ankyrin repeat domain-containing protein 4 isoform X2|organism=Schmidtea mediterranea sexual|type=transcript|length=4723bp
AGCAAAGTACAAGTATTTAAAAATATATAAATTATCTATTTATAATTGTA
TTTTTTATGTTAAAGAGTGAAGATAAAAGAACGAATAATAAGAAAATGAG
CCAACCGAGACAAAATTCCAATTCGTACATGACGAGAGAGTATTCAGTGA
GATCTCAAATCACCAATGAAATGCTAGCCAATGATAACAAATATCTAAAC
AATGAACCAGAATCACAATGGGGAATTAATCTTATAAATAACTCAGAAAC
TTTACCAACGAGATTCATCAATCGGAATCTGCCAACTTCACTTAATCGTG
CTTCAAATTTAAACAGCATGACAACTTCATCGATAAATTACCAAATGAAC
GAGCCTGATTTACAATGGAAAAACAATAATAATCGATTTGAATCAAGATT
AATGACTGATCTGCCAAGCCCGATGTCTGGAGTTCATAATTTGGCTTCGG
CAACTATGTCTCCCAATATTAACGATAACAGAGATCAGTTTTCTATCTAC
GGGTCTTTCAAAAAACACATTAGTGAAAAAAGAGACAGCTCAATGAAATA
TGATTCAACGCAAGTGATTGAAACTCGTGAAATCAATTATAAAAATTTGC
CAGTTAAACAATCGACAGCTAGTTATACATCTTCAGAGTTTGAAGTTCCA
GTAAATTCTGCATTGACTTCTTCAGGATTTTTCACTCCCCAGACTCGCAG
TCAACAATATACGTTGCAAGACATTCTCAATTCCGATGCCACCGATTCCA
TTAAAAATCAAATAGTTGAAGATGTTCCCATTAAAGCCGAAACTCAAAAT
CAAAATCAAAATTTCTCTAGCTTACCGGAAATTGTAGTTGAAACCCCTAA
AAACGAAATCGCTTCCAAAGATCAAGAAATAAAAAAACTGAATAAAACAA
TTGACAAACTGAACAACAAAATGAAAACTCTCCTGCAAAGCAATGAAGAA
ATGAAAACTCACTTAAAGAATCTTTTAAACGAAAGAAAAAACCTCATTAA
ACAAATCGAGAATTCAGAATTCGAGGAAATAATTGAAGAAGAAGAAGTTC
AAAGAGCTAAGCCTAACATTGCCACGAATGTGATTCCAAGCCAACAAAAA
TCCACTGTAATAAAACAAGAATTGATCAAAGAGAATTATCTAGAAAAAAG
TAAAATAAGTTTACAGGATTTGCCGCAACATATCTTAAATAAATACAGAC
AAGAGATCATAGATTGCGAAAGAGACAAAATCGAACTTGAAAAAAGAACA
TTAATTAATACACTAAATATTCAATATCAACAGCAACTGCAATCTTTGAG
ACACGAGCAAGACATTCGCAAAACCCAAATGAAACATGTCTCAATACAAA
GTTACAAAACAAAGAAATTCAACCAAACTGTGTCTGAAGTGAATTTGTCT
CGATCAACTCCTCCTCCCAAATCAATTGGAACCGTTTTCCAACCAGCAAC
ATTTTCGAAACAATCGCAAAATGACATTAAGGATGAAACGAATAAAAAAT
TAGCCAAAGATCTTGACATTCATTTTACAAATTACATTAGAAGACGACAA
ATTAAAACAACGGAATGGCAAAATACAATTCTGCAACAATTGACAGAATC
TTTGGACAAAAATAACTCAGAGCAATTTATGAATATCATTGAGGAAATTC
TTTTTAAATCATCGAAGAATATTTTAACCTCTGTCCAGCCAACTGTCAGT
AGTAAACTATCGCAAAATGAGGCGATAGAGGACGGAAATAAATCTCTTTC
TAGAGAAGTATCAAAATCATTGAACGAATACATAAGAAGTATTAAAATGA
AATTGTCTGATTGGCAGAAAATTATGTTGGAAAGATTTTTAAAATCTTTG
GAAATGAATGACGTAGACAATCTTTCATCGGTGATCGAGGAAATACTGTT
GAAACAAATGAAATCTGTCGAAACACTCTCTCAACCGGCTACGGTTAGTC
GATTGAGTCAAAATGACTCTAGTGAAGATTCGAATTCAAAGTTGGCAAAC
GAAGCCTTTACTTTATTCACTACGACCATGAGGAGTTCAAGAGTCACCAC
AACAAAATGGCAAGAGTCAATTGTAGAACGATTGATGAATTCCTTGAAAA
CCAATAATTCCCAAATGCTTTCAACGGTGATGGAAGAATTACTTTTTAAA
CCTTCGAGAACTATTGGCATTAACAGTGTACCCGATAACATGAATAAAAA
TAGCCAAACTCAACAAAAGAATTATAGCAATCTTTCTCATGAAGTTAACA
TTGTCGAAGAGAAACCGAAGTTTGAAAGATTATCGAAATCAGTTTCAGCA
AAACCAACAACCTTTCAAAAAGGAATTCAACCCGATGAGAAGTTTTTCTT
TGAAACTGGAACAATGACTGATCATTTGTTTTTTCGGAGTCAAGGAGTTA
ATACTTTGACTGATTATTCGAAAAATTTAAACTCACCATATTCGGAAACC
GATTCTTTCGTTACTAGGACCTCAAGTCGTAATGAATCAAAGAAAGAAAT
CAAGTCTCATACTGTTATCCAATCATCATCAAGCAACTTATTAAAACAAC
ATCAAAAATTACAGGAAAAGTTAGAAATTAAAATTGAACCTCAAAATAAA
AATATTACAGAAGAATGGAACCAGACTTTCTTGGTTAAAGAGCTTAAAGG
ATCAAATCAAAATGTTAGTACGACACTCGACAATATTAAATCAGAAGTAA
AAGAAGAAACAATTATTAAAGCACAAAATAAAACTCAGGAAACTGCTTCG
AAACCCCGAGAATTAATTGAAGAATGGGAGCAAAATATTGAAGAAAAGGT
CCAAGTCATGACTGCACATGTTGATAAAAACCAAAACATAAAAGATGATA
CACAGACGACTGTTGAATGCTGGGAGACAATCTCGAAAATAAAAGACGGA
AAATTAATCGAAAAAAAAGAATGCTACCGAGACAAATATGTCAGTTCGAA
CCCAGATGAAATTCGCAAACATCTTGAATCCCATGAACATAATCATAGCC
ATTCTAATTTCGAAGACAAAAATGATTCCGGAAAATCTGTTGAAACCCAT
AAACACTTTCATCAAAATGAAGAACACAATGAACACCAAAAAAACACTTT
GAGCAACTACGGAAATTCTAGACTCAATACAAAAACTTCTTCGAGTTCGT
TCAATGTTCCAGTAATAAAAGGTTTTGAAGAAACTGAAATTTCCAAATTC
AGAAACTACACAAATCTCGGTGTCAGCCGCAAAGAAGTTTCATCAATTGT
AGAACAACTCTCAAATTCCCAATTGAAAGAAAATCATTCAATATCGGAAA
GAATCGAACAAAGTTCCACATCGAAATCATTCAATTCTCCAATATCTTTC
ACGTCTTTCTCATCGATTTCTACCAACGATAAATCCAATTACGAACCGGC
AAACCAAAGGAAAATCGATATTTTATCGAGAAGTTCCAAGCCGAAAGTTT
TACCGAAACCGATCACAATTCAAAATTCCGAATCATTGCGATCATCACAA
GGAATCAATGTCAATCTCAAAACGTTTTCACCAACCATCGAATCTTCGGA
AATGTATTTTGATGAAACCGAGAACTCAACGGTCATTGGATCAGACAACA
GCGCTTTCTATTCGATATCAGAGCTACCGAAACCGAAGAAAGACGACCAA
AAATATGATTATCAAGAAGTTCTGCTGCCAGAAAACATATTCCAAATGTC
TAGCCAAGTGATGCTGTGGTTAAATACGAGCAAACTTGTTTCTATGAATA
ATATTGAGCATATGCCCCAAGAAATGATTAAGCCGTGCTTAATGCTAATT
GACTGGTGGGTAGACATGGTGATCAAGCTCTCCTCTAACCAACTTCTAAC
AACCGTCCAGTACCTCATTTCAACATTCAATAAGAATTTCGTCAAGTTTC
TTGTCATTAACAGAGATCAACAGGGAAATACTTGCATGCATTACATAATT
GGACATCAATTTTGGGAATCGTTTTCTGTGATTTATGCCACCGGTCTTGT
CGACCCAAACATATACAACGTCCAGGGTTTTACAGTAATGATGTTAGCAG
CAACTCTTCAAGTACCTGATGAAATACTAAATAACCACATTCGGAAACTA
GCGGATAAAGCCGATCTTAACCTTCAGTCAAAGGAACATGGACAGACTGC
CATCTACCTATCAGCTCTTCATGATAATGATAACACCATTACCACTTTGT
ATGCACTGGGAGCAGATATTAATATTAGGGATAGTGAGGAAAATACTCCT
TTAATGATTGCTACAATTAAGAACAACATTAAAGCTGTAAAAGCCATTTT
GGCTTGTCCCGGTGTATTGCTGGAATTAAAAAATAAAGATGGAAATTCAG
CTTTGAAACTCGCGGAACAGAATAATTTTTCAGAAATTAGTGCATTATTT
ACACAAAGAAGATCAATTCGACGTTCTGAAATATCAGGTTATTCAAAAAT
ACTAAGCTCAAACTCTAATCCTATATCCCCAAGAACCTTCAGAAAATATA
CCTACAATTAATCAAGAAATTATTAATTATCACATTTATGCTCATTTATA
GTTGTGATCAATAAATAAGTGCTTTTAATAAATATTTGCACGCTTTGCTG
TGAGTGCTGAATTTGAAATTGACATTTTGCTCATTCCAATTATTGTATTC
ATTGTTTTGTTATTTGATTTTTATACCTATAATGTTTTTTTATGTATTAT
TTATTATTGTGTTGATCGGTTAC

protein sequence of SMED30029492-orf-1

>SMED30029492-orf-1 ID=SMED30029492-orf-1|Name=SMED30029492-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1485bp
MLKSEDKRTNNKKMSQPRQNSNSYMTREYSVRSQITNEMLANDNKYLNNE
PESQWGINLINNSETLPTRFINRNLPTSLNRASNLNSMTTSSINYQMNEP
DLQWKNNNNRFESRLMTDLPSPMSGVHNLASATMSPNINDNRDQFSIYGS
FKKHISEKRDSSMKYDSTQVIETREINYKNLPVKQSTASYTSSEFEVPVN
SALTSSGFFTPQTRSQQYTLQDILNSDATDSIKNQIVEDVPIKAETQNQN
QNFSSLPEIVVETPKNEIASKDQEIKKLNKTIDKLNNKMKTLLQSNEEMK
THLKNLLNERKNLIKQIENSEFEEIIEEEEVQRAKPNIATNVIPSQQKST
VIKQELIKENYLEKSKISLQDLPQHILNKYRQEIIDCERDKIELEKRTLI
NTLNIQYQQQLQSLRHEQDIRKTQMKHVSIQSYKTKKFNQTVSEVNLSRS
TPPPKSIGTVFQPATFSKQSQNDIKDETNKKLAKDLDIHFTNYIRRRQIK
TTEWQNTILQQLTESLDKNNSEQFMNIIEEILFKSSKNILTSVQPTVSSK
LSQNEAIEDGNKSLSREVSKSLNEYIRSIKMKLSDWQKIMLERFLKSLEM
NDVDNLSSVIEEILLKQMKSVETLSQPATVSRLSQNDSSEDSNSKLANEA
FTLFTTTMRSSRVTTTKWQESIVERLMNSLKTNNSQMLSTVMEELLFKPS
RTIGINSVPDNMNKNSQTQQKNYSNLSHEVNIVEEKPKFERLSKSVSAKP
TTFQKGIQPDEKFFFETGTMTDHLFFRSQGVNTLTDYSKNLNSPYSETDS
FVTRTSSRNESKKEIKSHTVIQSSSSNLLKQHQKLQEKLEIKIEPQNKNI
TEEWNQTFLVKELKGSNQNVSTTLDNIKSEVKEETIIKAQNKTQETASKP
RELIEEWEQNIEEKVQVMTAHVDKNQNIKDDTQTTVECWETISKIKDGKL
IEKKECYRDKYVSSNPDEIRKHLESHEHNHSHSNFEDKNDSGKSVETHKH
FHQNEEHNEHQKNTLSNYGNSRLNTKTSSSSFNVPVIKGFEETEISKFRN
YTNLGVSRKEVSSIVEQLSNSQLKENHSISERIEQSSTSKSFNSPISFTS
FSSISTNDKSNYEPANQRKIDILSRSSKPKVLPKPITIQNSESLRSSQGI
NVNLKTFSPTIESSEMYFDETENSTVIGSDNSAFYSISELPKPKKDDQKY
DYQEVLLPENIFQMSSQVMLWLNTSKLVSMNNIEHMPQEMIKPCLMLIDW
WVDMVIKLSSNQLLTTVQYLISTFNKNFVKFLVINRDQQGNTCMHYIIGH
QFWESFSVIYATGLVDPNIYNVQGFTVMMLAATLQVPDEILNNHIRKLAD
KADLNLQSKEHGQTAIYLSALHDNDNTITTLYALGADINIRDSEENTPLM
IATIKNNIKAVKAILACPGVLLELKNKDGNSALKLAEQNNFSEISALFTQ
RRSIRRSEISGYSKILSSNSNPISPRTFRKYTYN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000018	Category 4 cell
PLANA:0000034	epidermis
PLANA:0000054	dorsal region of the epidermis
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR036770	Ankyrin_rpt-contain_sf
IPR002110	Ankyrin_rpt
IPR020683	Ankyrin_rpt-contain_dom
IPR018264	Ribosomal_L33_CS

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0003735	structural constituent of ribosome
GO:0008013	beta-catenin binding

Vocabulary: **biological process**
Term	Definition
GO:0006412	translation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010977	negative regulation of neuron projection development
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030336	negative regulation of cell migration
GO:0030837	negative regulation of actin filament polymerization
GO:0035024	negative regulation of Rho protein signal transduction
GO:0035413	positive regulation of catenin import into nucleus
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0090303	positive regulation of wound healing
GO:1900025	negative regulation of substrate adhesion-dependent cell spreading
GO:1900028	negative regulation of ruffle assembly
GO:2000114	regulation of establishment of cell polarity
GO:2000393	negative regulation of lamellipodium morphogenesis

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular
GO:0005840	ribosome
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0042995	cell projection

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 377..397
None	No IPR available	COILS	Coil	Coil	coord: 268..323
None	No IPR available	PFAM	PF13637	Ank_4	coord: 1364..1414 e-value: 1.0E-5 score: 25.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 976..1012
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 976..1014
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..26
None	No IPR available	PANTHER	PTHR24168	FAMILY NOT NAMED	coord: 1272..1460
IPR002110	Ankyrin repeat	SMART	SM00248	ANK_2a	coord: 1289..1319 e-value: 1800.0 score: 3.1 coord: 1361..1390 e-value: 0.082 score: 22.0 coord: 1394..1423 e-value: 41.0 score: 13.1
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 1361..1393 score: 11.434
IPR036770	Ankyrin repeat-containing domain superfamily	GENE3D	G3DSA:1.25.40.20		coord: 1248..1453 e-value: 6.5E-34 score: 119.5
IPR036770	Ankyrin repeat-containing domain superfamily	SUPERFAMILY	SSF48403	Ankyrin repeat	coord: 1263..1449
IPR020683	Ankyrin repeat-containing domain	PROSITE	PS50297	ANK_REP_REGION	coord: 1289..1451 score: 20.473

Main menu

KN motif and ankyrin repeat domain-containing protein 4 isoform X2

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Owlery

blazegraph-runner