Chloride intracellular channel 4

Overview
NameChloride intracellular channel 4
Smed IDSMED30029485
Length (bp)1016
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Chloride intracellular channel 4 (SMED30029485) t-SNE clustered cells

Violin plots show distribution of expression levels for Chloride intracellular channel 4 (SMED30029485) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Chloride intracellular channel 4 (SMED30029485) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Chloride intracellular channel 4 (SMED30029485) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30029485

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30029485h1SMcG0003403 Contig3691GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30029485h1SMcG0011725 Contig3691GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
pharynxSMED30029485h1SMcG0011725 dd_Smed_v4_3208_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30029485h1SMcG0011725 dd_Smed_v4_3208_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC4 (chloride intracellular channel 4 [Source:HGNC Symbol;Acc:HGNC:13518])

HSP 1 Score: 72.7886 bits (177), Expect = 3.537e-14
Identity = 59/241 (24.48%), Postives = 98/241 (40.66%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P+IELFVK    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P     S   T    +   + E             CP   L +  P+  ++     DI    +  +K          E+ L+  L ++D +L S                 + K L  +E+T  DC L+P+L  V+V  ++  +FDIP  +  + RY+ + Y    F  TC  D+++
Sbjct:   17 PLIELFVKAG-SDGESIGNCPFSQRLFMILWL----KGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVL-----------CPPKYLKL-SPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV 240
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC4 (chloride intracellular channel 4 [Source:HGNC Symbol;Acc:HGNC:13518])

HSP 1 Score: 72.7886 bits (177), Expect = 3.537e-14
Identity = 59/241 (24.48%), Postives = 98/241 (40.66%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P+IELFVK    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P     S   T    +   + E             CP   L +  P+  ++     DI    +  +K          E+ L+  L ++D +L S                 + K L  +E+T  DC L+P+L  V+V  ++  +FDIP  +  + RY+ + Y    F  TC  D+++
Sbjct:   17 PLIELFVKAG-SDGESIGNCPFSQRLFMILWL----KGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVL-----------CPPKYLKL-SPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV 240
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC2 (chloride intracellular channel 2 [Source:HGNC Symbol;Acc:HGNC:2063])

HSP 1 Score: 72.4034 bits (176), Expect = 5.129e-14
Identity = 65/237 (27.43%), Postives = 99/237 (41.77%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKN---EKPLITILTRIDIFLGSK---------------STKLLM-SDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P IELFVK    D E  G+CP  Q  FM  ++    K +   VT V+M  + E    L      P            K+L     +  + LE+ +     P L+ P Y        NL A     +    K  N   EK L+    R+D +L +                S +L +  D++T  DC L+P+L  ++VA ++   FDIP     + RY+ + Y  + F  TC +D++I
Sbjct:   12 PEIELFVKAG-SDGESIGNCPFCQRLFMILWL----KGVKFNVTTVDMTRKPEELKDLAPGTNPPFL-------VYNKELKTDFIKIEEFLEQTLAPPRYPHLS-PKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEI 235
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC1 (chloride intracellular channel 1 [Source:HGNC Symbol;Acc:HGNC:2062])

HSP 1 Score: 72.0182 bits (175), Expect = 5.884e-14
Identity = 64/249 (25.70%), Postives = 102/249 (40.96%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQL--TLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFL----------------GSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEE 736
            P +ELFVK    D    G+CP +Q  FM  ++    K +   VT V+ + + E+  +L    +LP     +   T            T+ +E+ +    CP     L   +PE   A     DI    +  +K  N       EK L+  L  +D +L                G    K L  +E+T  DC L+P+L  V+V  ++   F IP   + + RY+ + Y  + F  TC  D +I   +E+
Sbjct:    6 PQVELFVKAG-SDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTD-----------TNKIEEFLEAVLCPPRYPKLAALNPESNTA---GLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQ 235
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Match: CLIC1 (chloride intracellular channel 1 [Source:HGNC Symbol;Acc:HGNC:2062])

HSP 1 Score: 72.0182 bits (175), Expect = 5.884e-14
Identity = 64/249 (25.70%), Postives = 102/249 (40.96%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQL--TLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFL----------------GSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEE 736
            P +ELFVK    D    G+CP +Q  FM  ++    K +   VT V+ + + E+  +L    +LP     +   T            T+ +E+ +    CP     L   +PE   A     DI    +  +K  N       EK L+  L  +D +L                G    K L  +E+T  DC L+P+L  V+V  ++   F IP   + + RY+ + Y  + F  TC  D +I   +E+
Sbjct:    6 PQVELFVKAG-SDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTD-----------TNKIEEFLEAVLCPPRYPKLAALNPESNTA---GLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQ 235
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Celegans
Match: exc-4 (Chloride intracellular channel exc-4 [Source:UniProtKB/Swiss-Prot;Acc:Q8WQA4])

HSP 1 Score: 89.7373 bits (221), Expect = 2.540e-20
Identity = 71/259 (27.41%), Postives = 121/259 (46.72%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFN-CPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNE------KP----------------LITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLL 772
            P++EL+VK S  D    G+    Q ++M  Y L E  +  + V  VN+    E++ +  +  + P+   E       K+LT      TD+ E    IF+   +  +P+++ + + AE    ++ ++  + L+ K E      +P                +   L+ ID  L  + ++ L+ + +T  DC LMPRL H+R+ G  L  FDIP N  HL  YI   Y    F  +C  D+DII  ++E+++   N+R  L
Sbjct:   17 PLLELYVKASGIDARRIGADLFCQEFWMELYALYEIGVARVEVKTVNV--NSEAFKKNFLGAQPPIMIEEE------KELT-----YTDNREIEGRIFHLAKEFNVPLFEKDPS-AEKRIENLYRNFKLFLRAKVEFDKGKKEPSRVEDLPAQIKVHYNRVCEQLSNIDQLLSERKSRYLLGNSMTEYDCELMPRLHHIRIIGLSLLGFDIPHNFTHLWAYILTAYRTAAFIESCPADQDIIHHYKEQMNLFTNQRETL 261
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Celegans
Match: exl-1 (Chloride intracellular channel exl-1 [Source:UniProtKB/Swiss-Prot;Acc:O45405])

HSP 1 Score: 81.2629 bits (199), Expect = 1.314e-17
Identity = 65/212 (30.66%), Postives = 105/212 (49.53%), Query Frame = 2 
Query:  179 IDLRVTPVNMEMQCESYLQLNVSRRLP-VAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAADILKSLNILLK--TKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLTKDDSKLL 796
             D++ T VN   Q      L   RR+P ++  ESG + +         ET DD    I+ F      L    PE     +AEN   D+ +     +K     +    T L R+D +L  + TK L+SD+VT+ DC+++ RL  +RVA + L +++IP +L H++ Y+K  Y  ++F V+C  D++I+    E   T +    L  KD +KL+
Sbjct:   42 FDVKTTNVNKTSQEFKNTGL---RRMPGISAEESGETQT--------FETEDD----ILDF------LEYLKPERGDDEEAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPR----LSAKDRAKLV 228
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Celegans
Match: exl-1 (Chloride intracellular channel exl-1 [Source:UniProtKB/Swiss-Prot;Acc:O45405])

HSP 1 Score: 81.2629 bits (199), Expect = 1.314e-17
Identity = 65/212 (30.66%), Postives = 105/212 (49.53%), Query Frame = 2 
Query:  179 IDLRVTPVNMEMQCESYLQLNVSRRLP-VAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAADILKSLNILLK--TKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLTKDDSKLL 796
             D++ T VN   Q      L   RR+P ++  ESG + +         ET DD    I+ F      L    PE     +AEN   D+ +     +K     +    T L R+D +L  + TK L+SD+VT+ DC+++ RL  +RVA + L +++IP +L H++ Y+K  Y  ++F V+C  D++I+    E   T +    L  KD +KL+
Sbjct:   42 FDVKTTNVNKTSQEFKNTGL---RRMPGISAEESGETQT--------FETEDD----ILDF------LEYLKPERGDDEEAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPR----LSAKDRAKLV 228
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Fly
Match: Clic (gene:FBgn0030529 transcript:FBtr0346089)

HSP 1 Score: 111.309 bits (277), Expect = 2.421e-28
Identity = 83/255 (32.55%), Postives = 129/255 (50.59%), Query Frame = 2 
Query:   62 IPVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNE---KPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTG-KNRRSLLTKDDSKLLTIDITD 814
            +P IEL +K S  D    G+C   Q +FM  Y+L E K I L+VT V+M+     + + N     P   +++G +     L N      + +E+ IM        L + D EVA    L  ++   L ++L  K+E     L++ L +I+  L +++T+ L  D +   DC LMPRLQH+RVAG+    F+IP +L  L RY+ HMY    F  +C  D+DII  ++ + S   K    L T   +  + IDI++
Sbjct:   20 VPEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDF-RTNFEATHPPILIDNGLAI----LEN------EKIERHIMKNIPGGYNLFVQDKEVA---TLIENLYVKLKLMLVKKDEAKNNALLSHLRKINDHLSARNTRFLTGDTMCCFDCELMPRLQHIRVAGKYFVDFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDIINHYKLQQSLKMKKHEELETPTFTTYIPIDISE 260
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Fly
Match: Clic (gene:FBgn0030529 transcript:FBtr0073835)

HSP 1 Score: 111.309 bits (277), Expect = 2.421e-28
Identity = 83/255 (32.55%), Postives = 129/255 (50.59%), Query Frame = 2 
Query:   62 IPVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNE---KPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTG-KNRRSLLTKDDSKLLTIDITD 814
            +P IEL +K S  D    G+C   Q +FM  Y+L E K I L+VT V+M+     + + N     P   +++G +     L N      + +E+ IM        L + D EVA    L  ++   L ++L  K+E     L++ L +I+  L +++T+ L  D +   DC LMPRLQH+RVAG+    F+IP +L  L RY+ HMY    F  +C  D+DII  ++ + S   K    L T   +  + IDI++
Sbjct:   20 VPEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDF-RTNFEATHPPILIDNGLAI----LEN------EKIERHIMKNIPGGYNLFVQDKEVA---TLIENLYVKLKLMLVKKDEAKNNALLSHLRKINDHLSARNTRFLTGDTMCCFDCELMPRLQHIRVAGKYFVDFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDIINHYKLQQSLKMKKHEELETPTFTTYIPIDISE 260
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: clic2 (chloride intracellular channel 2 [Source:ZFIN;Acc:ZDB-GENE-040718-299])

HSP 1 Score: 75.485 bits (184), Expect = 2.407e-15
Identity = 62/235 (26.38%), Postives = 102/235 (43.40%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTK-----NEKPLITILTRIDIFLGS------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P IELF+K   +D E+ G+CP  Q  FM  ++    K +   VT V+M  + +    L      P   + +GT      L     +  + LE  +     P L+     P   ++ ++ ADI    +  +K       +EK L+    R+D +L +               K L  + +T  DC L+P+L  ++VA R+  +FDIP     + RY++  Y  + F  TC  D +I
Sbjct:   11 PRIELFIKAG-HDGENVGNCPFCQRLFMVLWL----KGVKFTVTTVDMRKKPDELKDLAPGTNPPFL-LYNGT------LKTDFIKIEEFLETTLAPPRYPHLS-----PRYKESFDVGADIFAKFSAFIKNSPNNAFHEKALLREFKRLDDYLNTPLQDELDQNISVSKRKFLDGNRLTLADCNLLPKLHVIKVAARKYCNFDIPTQFTGVWRYLQSAYEREEFSQTCPADIEI 228
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: clic2 (chloride intracellular channel 2 [Source:ZFIN;Acc:ZDB-GENE-040718-299])

HSP 1 Score: 75.485 bits (184), Expect = 2.407e-15
Identity = 62/235 (26.38%), Postives = 102/235 (43.40%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTK-----NEKPLITILTRIDIFLGS------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P IELF+K   +D E+ G+CP  Q  FM  ++    K +   VT V+M  + +    L      P   + +GT      L     +  + LE  +     P L+     P   ++ ++ ADI    +  +K       +EK L+    R+D +L +               K L  + +T  DC L+P+L  ++VA R+  +FDIP     + RY++  Y  + F  TC  D +I
Sbjct:   11 PRIELFIKAG-HDGENVGNCPFCQRLFMVLWL----KGVKFTVTTVDMRKKPDELKDLAPGTNPPFL-LYNGT------LKTDFIKIEEFLETTLAPPRYPHLS-----PRYKESFDVGADIFAKFSAFIKNSPNNAFHEKALLREFKRLDDYLNTPLQDELDQNISVSKRKFLDGNRLTLADCNLLPKLHVIKVAARKYCNFDIPTQFTGVWRYLQSAYEREEFSQTCPADIEI 228
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: clic2 (chloride intracellular channel 2 [Source:ZFIN;Acc:ZDB-GENE-040718-299])

HSP 1 Score: 75.485 bits (184), Expect = 2.407e-15
Identity = 62/235 (26.38%), Postives = 102/235 (43.40%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTK-----NEKPLITILTRIDIFLGS------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P IELF+K   +D E+ G+CP  Q  FM  ++    K +   VT V+M  + +    L      P   + +GT      L     +  + LE  +     P L+     P   ++ ++ ADI    +  +K       +EK L+    R+D +L +               K L  + +T  DC L+P+L  ++VA R+  +FDIP     + RY++  Y  + F  TC  D +I
Sbjct:   11 PRIELFIKAG-HDGENVGNCPFCQRLFMVLWL----KGVKFTVTTVDMRKKPDELKDLAPGTNPPFL-LYNGT------LKTDFIKIEEFLETTLAPPRYPHLS-----PRYKESFDVGADIFAKFSAFIKNSPNNAFHEKALLREFKRLDDYLNTPLQDELDQNISVSKRKFLDGNRLTLADCNLLPKLHVIKVAARKYCNFDIPTQFTGVWRYLQSAYEREEFSQTCPADIEI 228
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: pnpla7a (patatin-like phospholipase domain containing 7a [Source:ZFIN;Acc:ZDB-GENE-070112-1812])

HSP 1 Score: 70.8626 bits (172), Expect = 9.758e-14
Identity = 68/242 (28.10%), Postives = 103/242 (42.56%), Query Frame = 2 
Query:   71 IELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAAD-ILKSLNILLKTKN-------EKPLITILTRIDIFL--------------GSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDII 721
            IELFVK S  D E  G+CP  Q  FM  ++    K ++  +T V+M+   E    L    + P         T     TN I E  +D            L  P Y P++    K  N A D I    +  +K  N       EK  +  L ++D +L               + +   L  + ++  DC L+P+L  V+V  ++   F+IP  LK L +Y+   Y E VF +TC KD++I+
Sbjct:    7 IELFVKAS-DDGESVGNCPFCQRLFMILWL----KGVNFTLTTVDMKRAPEVLKDLAPGSQPPFLIYNGEVRTD----TNKIEEFLED-----------TLAPPQY-PKLCCRYKESNTAGDDIFHKFSAYIKNPNPGLNDMLEKKFLKSLMKLDQYLLTPLPHELDQNPELSTSTRHYLDGNALSLADCNLLPKLHIVKVVCKKYRGFEIPAELKGLSKYLDKAYKEDVFHLTCPKDKEIL 227
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Match: clic3 (chloride intracellular channel 3 [Source:ZFIN;Acc:ZDB-GENE-010507-2])

HSP 1 Score: 70.8626 bits (172), Expect = 9.758e-14
Identity = 68/242 (28.10%), Postives = 103/242 (42.56%), Query Frame = 2 
Query:   71 IELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAAD-ILKSLNILLKTKN-------EKPLITILTRIDIFL--------------GSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDII 721
            IELFVK S  D E  G+CP  Q  FM  ++    K ++  +T V+M+   E    L    + P         T     TN I E  +D            L  P Y P++    K  N A D I    +  +K  N       EK  +  L ++D +L               + +   L  + ++  DC L+P+L  V+V  ++   F+IP  LK L +Y+   Y E VF +TC KD++I+
Sbjct:    7 IELFVKAS-DDGESVGNCPFCQRLFMILWL----KGVNFTLTTVDMKRAPEVLKDLAPGSQPPFLIYNGEVRTD----TNKIEEFLED-----------TLAPPQY-PKLCCRYKESNTAGDDIFHKFSAYIKNPNPGLNDMLEKKFLKSLMKLDQYLLTPLPHELDQNPELSTSTRHYLDGNALSLADCNLLPKLHIVKVVCKKYRGFEIPAELKGLSKYLDKAYKEDVFHLTCPKDKEIL 227
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: st3gal5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Source:Xenbase;Acc:XB-GENE-955106])

HSP 1 Score: 68.9366 bits (167), Expect = 7.594e-13
Identity = 61/244 (25.00%), Postives = 97/244 (39.75%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAA-DILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRD 715
            P IELFVK    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P         T    +   + E+               L  P Y P++A   +  N A  DI    +  +K          EK L   L ++D +L S                   K L  DE T  DC L+P+L  V++  ++  +++IP  +  + RY+K+ Y    F  TC+ D++
Sbjct:   14 PDIELFVKAG-SDGESIGNCPFSQRLFMILWL----KGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGEVKTDVNKIEEFLEES---------------LAPPRY-PKLAAKHRESNTAGIDIFSKFSAYIKNTKQQDNAGLEKGLTKALKKLDTYLNSPLPEEIDANSREEEKVSKRKFLDGDEFTLADCNLLPKLHVVKIVAKKYRNYEIPAEMSGIWRYLKNAYARDEFTNTCAADKE 236
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: clic1 (chloride intracellular channel 1 [Source:NCBI gene;Acc:394484])

HSP 1 Score: 67.3958 bits (163), Expect = 2.210e-12
Identity = 63/251 (25.10%), Postives = 102/251 (40.64%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAA-DILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEE 736
            P +ELFVK +  D +  G+CP +Q  FM  ++    K +   VT V+M+ + +    L    + P         T    +   + ET            CP    P Y P++A   +  N A  D+    +  +K  N       EK L+  L  +DI+L +                 + K L  +E+T  DC L+P+L  V+V       F IP     + RY+++ Y  + F  TC    +I+  + E
Sbjct:    5 PQVELFVKAA-NDGQSIGNCPFSQRLFMVLWL----KGVTFNVTTVDMKKKPDILKDLAPGAQPPFLLFAGEVRTDTNKIEEFLEETL-----------CP----PKY-PKLACRNQESNTAGLDVFARFSAYIKNSNPAPNQSVEKGLLKALKVLDIYLNTPQIDEIDENSAEDEPVSNRKFLDGNELTLADCNLLPKLNIVQVVCEHFRGFKIPAEFTGIHRYLQNAYKREEFASTCPDAAEIVRAYAE 234
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: clic4 (chloride intracellular channel 5 [Source:NCBI gene;Acc:493290])

HSP 1 Score: 65.4698 bits (158), Expect = 1.190e-11
Identity = 57/246 (23.17%), Postives = 100/246 (40.65%), Query Frame = 2 
Query:   68 VIELFVKCSLYDKEDFGSCPINQTWFMAFY---VLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAK---AENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            ++ELFVK    D E  G+CP +Q  FM  +   V+     +DL+  P +++                   +  GT        + +    + +E+ +    CP    P Y    AK   +     DI    +  +K          E+ L+  L ++D +L S                 + K L  +E+T  DC L+P+L  ++V  ++   F+IP ++  + RY+ + Y +  F  TC  DR+I
Sbjct:   17 LVELFVKAG-SDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLQ------------------NLAPGTHPPFITYNHEVKTDVNKIEEFLEEVLCP----PKYRKLAAKHPESNTAGMDIFAKFSAYIKNSRPDNNEALERGLLKTLQKLDDYLNSPLPDEIDENSMDDITQSNRKFLDGEEMTLADCNLLPKLHIIKVVTKKYRGFEIPKSMTGIWRYLSNAYSKDEFTNTCPGDREI 239
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: st3gal5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Source:Xenbase;Acc:XB-GENE-955106])

HSP 1 Score: 62.7734 bits (151), Expect = 2.287e-10
Identity = 57/244 (23.36%), Postives = 96/244 (39.34%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAA-DILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRD 715
            P I +++K    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P         T    +   + E+               L  P Y P++A   +  N A  DI    +  +K          EK L   L ++D +L S                   K L  DE T  DC L+P+L  V++  ++  +++IP  +  + RY+K+ Y    F  TC+ D++
Sbjct:  148 PDIAIYIKAG-SDGESIGNCPFSQRLFMILWL----KGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGEVKTDVNKIEEFLEES---------------LAPPRY-PKLAAKHRESNTAGIDIFSKFSAYIKNTKQQDNAGLEKGLTKALKKLDTYLNSPLPEEIDANSREEEKVSKRKFLDGDEFTLADCNLLPKLHVVKIVAKKYRNYEIPAEMSGIWRYLKNAYARDEFTNTCAADKE 370
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Match: CLIC6 (chloride intracellular channel 6 [Source:NCBI gene;Acc:100486547])

HSP 1 Score: 61.2326 bits (147), Expect = 2.498e-10
Identity = 50/232 (21.55%), Postives = 91/232 (39.22%), Query Frame = 2 
Query:  101 DKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYD---PEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P    +    T    +   + E               +LT+P Y    P+  ++ +   D+    +  +K          EK  +  L ++D FL +                   K L  +E+T  DC L+P+LQ ++V  ++  +F+IP ++  + RY+   +    F  TC  D +I
Sbjct:   16 DGESIGNCPFSQRLFMILWL----KGVVFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEE---------------RLTMPRYPKLAPKHPESSSAGNDVFAKFSAYIKNPRKDLNAALEKGFLRSLRKLDDFLNTPLPDEIDAYSTEDITISDRKFLDGNELTLADCNLLPKLQIIKVVAKKYRNFEIPTDMTGIWRYLNSAFARDEFTNTCPADSEI 228
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic4 (chloride intracellular channel 4 (mitochondrial) [Source:MGI Symbol;Acc:MGI:1352754])

HSP 1 Score: 74.3294 bits (181), Expect = 8.291e-15
Identity = 59/241 (24.48%), Postives = 98/241 (40.66%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P+IELFVK    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P     S   T    +   + E             CP   L +  P+  ++     DI    +  +K          E+ L+  L ++D +L S                 + + L  DE+T  DC L+P+L  V+V  ++  +FDIP  +  + RY+ + Y    F  TC  D+++
Sbjct:   17 PLIELFVKAG-SDGESIGNCPFSQRLFMILWL----KGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVL-----------CPPKYLKL-SPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEV 240
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic5 (chloride intracellular channel 5 [Source:MGI Symbol;Acc:MGI:1917912])

HSP 1 Score: 72.4034 bits (176), Expect = 3.250e-14
Identity = 63/241 (26.14%), Postives = 97/241 (40.25%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P IELFVK  + D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P         T      N I E    LE+ +     P+L     +   A       DI    +  +K          E+ L   L ++D +L S                   K L  DE+T  DC L+P+L  V++  ++  ++DIP  +  L RY+K+ Y    F  TC+ D +I
Sbjct:   14 PEIELFVKAGI-DGESIGNCPFSQRLFMILWL----KGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTD----VNKIEEF---LEETLTPEKYPKLAAKHRESNTA-----GIDIFSKFSAYIKNTKQQNNAALERGLTKALRKLDDYLNSPLPEEIDTNTHGDEKGSQRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEI 237
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic1 (chloride intracellular channel 1 [Source:MGI Symbol;Acc:MGI:2148924])

HSP 1 Score: 71.2478 bits (173), Expect = 6.813e-14
Identity = 64/251 (25.50%), Postives = 105/251 (41.83%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA----KAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFL----------------GSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEE 736
            P +ELFVK    D    G+CP +Q  FM  ++    K +   VT V+ + + E+  +L    +LP     +   T            T+ +E+ +    CP    P Y P++A    ++     DI    +  +K  N       EK L+  L  +D +L                G    K L  +E+T  DC L+P+L  V+V  ++   F IP   + + RY+ + Y  + F  TC  D +I   +E+
Sbjct:    6 PQVELFVKAG-SDGAKIGNCPFSQRLFMVLWL----KGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTD-----------TNKIEEFLEAMLCP----PRY-PKLAALNPESNTSGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGISQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQ 235
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic5 (chloride intracellular channel 5 [Source:MGI Symbol;Acc:MGI:1917912])

HSP 1 Score: 67.3958 bits (163), Expect = 5.659e-12
Identity = 63/248 (25.40%), Postives = 100/248 (40.32%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFY---VLVENKLIDLRVTPVNMEMQCES----YLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLK-TKN------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P I LFVK  + D E  G+CP +Q  FM  +   V+     +DL+  P ++          +L  N   +  V K+E                  + LE+ +     P+L     +   A       DI    +  +K TK       E+ L   L ++D +L S                   K L  DE+T  DC L+P+L  V++  ++  ++DIP  +  L RY+K+ Y    F  TC+ D +I
Sbjct:  248 PEIFLFVKAGI-DGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIE------------------EFLEETLTPEKYPKLAAKHRESNTA-----GIDIFSKFSAYIKNTKQQNNAALERGLTKALRKLDDYLNSPLPEEIDTNTHGDEKGSQRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEI 471
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Match: Clic6 (chloride intracellular channel 6 [Source:MGI Symbol;Acc:MGI:2146607])

HSP 1 Score: 65.855 bits (159), Expect = 2.043e-11
Identity = 64/239 (26.78%), Postives = 99/239 (41.42%), Query Frame = 2 
Query:   71 IELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLK-TKN------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            I LFVK   YD E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P    +    T      N I E    LE+ ++    P+L      PE   A N   D+    +  +K TK       EK L+  L ++D +L S                   K L  DE+T  DC L+P+L  +++  ++   F+ P  +  + RY+ + Y    F  TC  DR+I
Sbjct:  363 ITLFVKAG-YDGESIGNCPFSQRLFMILWL----KGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTD----VNKIEEF---LEEKLVPPRYPKLG--TQHPESNSAGN---DVFAKFSAFIKNTKKDANEIYEKNLLRALKKLDSYLNSPLPDEIDADSSEDVTVSQRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADREI 584
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|Q8WQA4|EXC4_CAEEL (Chloride intracellular channel exc-4 OS=Caenorhabditis elegans OX=6239 GN=exc-4 PE=1 SV=2)

HSP 1 Score: 89.7373 bits (221), Expect = 3.231e-19
Identity = 71/259 (27.41%), Postives = 121/259 (46.72%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFN-CPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNE------KP----------------LITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLL 772
            P++EL+VK S  D    G+    Q ++M  Y L E  +  + V  VN+    E++ +  +  + P+   E       K+LT      TD+ E    IF+   +  +P+++ + + AE    ++ ++  + L+ K E      +P                +   L+ ID  L  + ++ L+ + +T  DC LMPRL H+R+ G  L  FDIP N  HL  YI   Y    F  +C  D+DII  ++E+++   N+R  L
Sbjct:   17 PLLELYVKASGIDARRIGADLFCQEFWMELYALYEIGVARVEVKTVNV--NSEAFKKNFLGAQPPIMIEEE------KELT-----YTDNREIEGRIFHLAKEFNVPLFEKDPS-AEKRIENLYRNFKLFLRAKVEFDKGKKEPSRVEDLPAQIKVHYNRVCEQLSNIDQLLSERKSRYLLGNSMTEYDCELMPRLHHIRIIGLSLLGFDIPHNFTHLWAYILTAYRTAAFIESCPADQDIIHHYKEQMNLFTNQRETL 261
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|O45405|EXL1_CAEEL (Chloride intracellular channel exl-1 OS=Caenorhabditis elegans OX=6239 GN=exl-1 PE=2 SV=2)

HSP 1 Score: 81.2629 bits (199), Expect = 1.672e-16
Identity = 65/212 (30.66%), Postives = 105/212 (49.53%), Query Frame = 2 
Query:  179 IDLRVTPVNMEMQCESYLQLNVSRRLP-VAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAADILKSLNILLK--TKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLTKDDSKLL 796
             D++ T VN   Q      L   RR+P ++  ESG + +         ET DD    I+ F      L    PE     +AEN   D+ +     +K     +    T L R+D +L  + TK L+SD+VT+ DC+++ RL  +RVA + L +++IP +L H++ Y+K  Y  ++F V+C  D++I+    E   T +    L  KD +KL+
Sbjct:   42 FDVKTTNVNKTSQEFKNTGL---RRMPGISAEESGETQT--------FETEDD----ILDF------LEYLKPERGDDEEAENATCDLFRQFARFVKDVEHRDTAFNTELLRLDKYLSEQETKFLISDDVTHIDCLVLTRLHSIRVAAKMLKNYEIPADLSHVLDYLKAGYATEMFRVSCPSDQEIVLHWTELKDTPR----LSAKDRAKLV 228
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|Q9XSA7|CLIC4_BOVIN (Chloride intracellular channel protein 4 OS=Bos taurus OX=9913 GN=CLIC4 PE=2 SV=3)

HSP 1 Score: 75.0998 bits (183), Expect = 2.694e-14
Identity = 58/244 (23.77%), Postives = 101/244 (41.39%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFY---VLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P+IELFVK    D E  G+CP +Q  FM  +   V+     +DL+  P +++                   +  GT        N +    + +E+ +    CP   L +  P+  ++     DI    +  +K          E+ L+  L ++D +L S                 + K L  +E+T  DC L+P+L  V+V  ++  +FDIP  +  + RY+ + Y    F  TC  D+++
Sbjct:   17 PIIELFVKAG-SDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQ------------------NLAPGTHPPFITFNNEVKTDVNKIEEFLEEVLCPPKYLKL-SPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEV 240
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|Q5R957|CLIC4_PONAB (Chloride intracellular channel protein 4 OS=Pongo abelii OX=9601 GN=CLIC4 PE=2 SV=3)

HSP 1 Score: 74.3294 bits (181), Expect = 5.525e-14
Identity = 58/244 (23.77%), Postives = 101/244 (41.39%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFY---VLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P+IELFVK    D E  G+CP +Q  FM  +   V+     +DL+  P +++                   +  GT        + +    + +E+ +    CP   L +  P+  ++     DI    +  +K          E+ L+  L ++D +L S                 + K L  DE+T  DC L+P+L  V+V  ++  +FDIP  +  + RY+ + Y    F  TC  D+++
Sbjct:   17 PLIELFVKAG-SDGESIGNCPFSQRLFMILWLKGVVFSVSTVDLKRKPADLQ------------------NLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKL-SPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEV 240
[Close]
BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Match: sp|Q9QYB1|CLIC4_MOUSE (Chloride intracellular channel protein 4 OS=Mus musculus OX=10090 GN=Clic4 PE=1 SV=3)

HSP 1 Score: 74.3294 bits (181), Expect = 5.800e-14
Identity = 59/241 (24.48%), Postives = 98/241 (40.66%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P+IELFVK    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P     S   T    +   + E             CP   L +  P+  ++     DI    +  +K          E+ L+  L ++D +L S                 + + L  DE+T  DC L+P+L  V+V  ++  +FDIP  +  + RY+ + Y    F  TC  D+++
Sbjct:   17 PLIELFVKAG-SDGESIGNCPFSQRLFMILWL----KGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVL-----------CPPKYLKL-SPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEV 240
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A1I8GES9 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011978g2 PE=4 SV=1)

HSP 1 Score: 219.935 bits (559), Expect = 2.172e-66
Identity = 109/246 (44.31%), Postives = 154/246 (62.60%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTG--KNRRSLLTKDDSKLL 796
            PV+ELF+K S   KED G CPI+Q WFM FY+L E K ++L VT VN +M  E+Y  L V R LPVA+V  G    G DL+N + +T D++E+L+ I+ CP L LP    +  +AE    D+ K+LN++LKT+N  PL+ +L RID FLGS+  + L+SDE+TY DC LMP+L HV++AG+    FD+P +L +L  Y   MY  + F  +C  DRD+   + +K+       R      DDS++L
Sbjct:   16 PVVELFIKASHICKEDKGPCPISQQWFMVFYILAEKKYLNLFVTTVNPDMPPEAYQALEVGRHLPVARVIKGADPRGSDLSNTVFDTNDEIEQLMDIWKCPCLALPKESADEGEAEKAFYDLYKNLNLMLKTENSTPLLHVLRRIDSFLGSRGCRFLLSDELTYADCQLMPKLHHVKMAGKFYRDFDVPADLNNLQAYYSAMYDCEAFRCSCPADRDLYQLYHDKLPKNLVAQRPQPSLMDDSRVL 261
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A1I8GET5 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013060g1 PE=4 SV=1)

HSP 1 Score: 218.779 bits (556), Expect = 6.266e-66
Identity = 109/246 (44.31%), Postives = 154/246 (62.60%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTG--KNRRSLLTKDDSKLL 796
            PV+ELF+K S   KED G CPI+Q WFM FY+L E K ++L VT VN +M  E+Y  L V R LPVA+V  G    G DL+N + +T D++E+L+ I+ CP L LP    +  +AE    D+ K+LN++LKT+N  PL+ +L RID FLGS+  + L+SDE+TY DC LMP+L HV++AG+    FD+P +L +L  Y   MY  + F  +C  DRD+   + +K+       R      DDS++L
Sbjct:   16 PVVELFIKASHICKEDKGPCPISQQWFMVFYILAEKKYLNLFVTTVNPDMPPEAYQALEVGRHLPVARVIKGADPRGSDLSNTVFDTNDEIEQLMDIWKCPCLALPKESADEGEAEKAFYDLYKNLNLMLKTENSTPLLHVLRRIDSFLGSRGCRFLLSDELTYADCQLMPKLHHVKMAGKFYRDFDVPADLNNLQAYYSAMYDCEAFRCSCPADRDLYQLYYDKLPKNLVAQRPQPSLMDDSRVL 261
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A1I8G169 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig011978g1 PE=4 SV=1)

HSP 1 Score: 218.394 bits (555), Expect = 7.862e-66
Identity = 109/246 (44.31%), Postives = 154/246 (62.60%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTG--KNRRSLLTKDDSKLL 796
            PV+ELF+K S   KED G CPI+Q WFM FY+L E K ++L VT VN +M  E+Y  L V R LPVA+V  G    G DL+N + +T D++E+L+ I+ CP L LP    +  +AE    D+ K+LN++LKT+N  PL+ +L RID FLGS+  + L+SDE+TY DC LMP+L HV++AG+    FD+P +L +L  Y   MY  + F  +C  DRD+   + +K+       R      DDS++L
Sbjct:   16 PVVELFIKASHICKEDKGPCPISQQWFMVFYILAEKKYLNLFVTTVNPDMPPEAYQALEVGRHLPVARVIKGADPRGSDLSNTVFDTNDEIEQLMDIWKCPCLALPKESADEGEAEKAFYDLYKNLNLMLKTENSTPLLHVLRRIDSFLGSRGCRYLLSDELTYADCQLMPKLHHVKMAGKFYRDFDVPADLNNLQAYYSAMYDCEAFRCSCPADRDLYQLYYDKLPKNLVAQRPQPSLMDDSRVL 261
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A267GVZ3 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig002946g1 PE=4 SV=1)

HSP 1 Score: 200.675 bits (509), Expect = 6.732e-59
Identity = 110/243 (45.27%), Postives = 146/243 (60.08%), Query Frame = 2 
Query:   62 IPVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTS----TSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLE-KVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLT 775
            IP IELF+K S   +E+ G CPI+Q W +AFY+L E KL +L +T VN ++  +SYL LNVSRRLPVA V  G      TS        A+T D++E+L+  F CP L LP    + A AE    D+ K+ +++LKT N  PLI  L +ID FLG +  + L+SDE+TY DC LMP+L HVR+AG     F IP  L+HL  Y+  MY     F  +C  DRDI+  + +KV      RSLL+
Sbjct:   19 IPSIELFIKASQIAREEKGPCPISQQWILAFYILAEKKLTELYLTTVNPDVPPDSYLALNVSRRLPVANVTKGPDPRLKTSNAADAPDPADTNDEIEQLMDAFRCPNLALPKDSRDEANAEKAICDLYKNFSLMLKTDNRAPLINSLRKIDNFLGLRPCRYLLSDELTYADCQLMPKLHHVRLAGEFYRGFTIPEELRHLQDYLVGMYTACDAFRTSCPADRDILHLYYDKVP-----RSLLS 256
[Close]
BLAST of Chloride intracellular channel 4 vs. TrEMBL
Match: A0A1I8G6K1 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig003947g1 PE=4 SV=1)

HSP 1 Score: 200.675 bits (509), Expect = 7.260e-59
Identity = 110/243 (45.27%), Postives = 146/243 (60.08%), Query Frame = 2 
Query:   62 IPVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTS----TSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLE-KVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLT 775
            IP IELF+K S   +E+ G CPI+Q W +AFY+L E KL +L +T VN ++  +SYL LNVSRRLPVA V  G      TS        A+T D++E+L+  F CP L LP    + A AE    D+ K+ +++LKT N  PLI  L +ID FLG +  + L+SDE+TY DC LMP+L HVR+AG     F IP  L+HL  Y+  MY     F  +C  DRDI+  + +KV      RSLL+
Sbjct:   19 IPSIELFIKASQIAREEKGPCPISQQWILAFYILAEKKLTELYLTTVNPDVPPDSYLALNVSRRLPVANVTKGPDPRLKTSNAADAPDPADTNDEIEQLMDAFRCPNLALPKDSRDEANAEKAICDLYKNFSLMLKTDNRAPLINSLRKIDNFLGLRPCRYLLSDELTYADCQLMPKLHHVRLAGEFYRGFTIPEELRHLQDYLVGMYTACDAFRTSCPADRDILHLYYDKVP-----RSLLS 256
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: clic2 (chloride intracellular channel 2 [Source:NCBI gene;Acc:103028266])

HSP 1 Score: 69.3218 bits (168), Expect = 2.985e-13
Identity = 65/255 (25.49%), Postives = 112/255 (43.92%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTK-----NEKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRS 766
            P IELF+K   +D E+ G+CP  Q+ FM  ++    K +   VT V+M  + E    L      P          +G   T+ I +  + LE  +     P L+     P   ++ ++ ADI    +  +K        E+ L+    R+DI+L +                 S K L  + +T  DC L+P+L  ++VA ++  +FDIP +   + RY+++    + F  TC  + +I    E+   +  N+RS
Sbjct:   11 PTIELFIKAG-HDGENVGNCPFCQSLFMVLWL----KGVKFTVTTVDMRKKPEELKDLAPGTNPPFLLY------NGVLKTDFI-KIEEFLETTLAPPRYPHLS-----PLNKESFDVGADIFAKFSAFIKNSPNNSIQEQALLREFKRLDIYLSTPLPEEIDHNSRENITVSSRKYLDGNRLTLADCNLLPKLHVIKVAAKKYCNFDIPAHFSAVHRYLQNANAREEFIQTCPANIEI----EKAYLSVANKRS 244
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: clic4 (chloride intracellular channel 4 [Source:NCBI gene;Acc:103041029])

HSP 1 Score: 67.781 bits (164), Expect = 9.764e-13
Identity = 62/243 (25.51%), Postives = 100/243 (41.15%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLT-LPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS-----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            PVIELFVK    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P         T      N I E  +D      + + P+ + L    PE   A     DI    +  +K          E+ L+  L ++D +L S                  + K L  D++T  DC L+P+L  V+V  ++   F+IP ++  +  Y+ + Y  + F  TC  D++I
Sbjct:   15 PVIELFVKAG-SDGESIGNCPFSQRLFMILWL----KGVVFNVTTVDLKRKPADLQNLAPGTHPPFITFNGEVKTD----VNKIEEFLED------VLSPPKYSKLGARHPESNTA---GMDIFAKFSAYIKNSRPDTNEGLERGLLKTLQKLDEYLRSPLPDEIDHNSMDDDIKVSARKFLDGDDMTLADCNLLPKLHIVKVVAKKYRGFEIPKDMLGIWGYLNNAYTREEFTNTCPSDKEI 239
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: clic5a (chloride intracellular channel 5 [Source:NCBI gene;Acc:103041670])

HSP 1 Score: 67.3958 bits (163), Expect = 1.184e-12
Identity = 62/241 (25.73%), Postives = 100/241 (41.49%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P IELFVK    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P         T      N I E    LE+++     P+L+    +   A       DI    +  +K          E  L+  L ++D +L +                 + K L S+E+T  DC L+P+L  V+V  ++  +FDIP     + RY+++ Y    F  TC+ D++I
Sbjct:    7 PDIELFVKAG-SDGESIGNCPFSQRLFMILWL----KGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGEVQTD----VNKIEEY---LEEMLAPPKYPKLSAKNRESNTA-----GNDIFSKFSAYVKNTQPEANASLENGLLKALRKLDNYLNTPLPEEIDADSMEEEKCSTRKYLDSNELTLADCNLLPKLHVVKVVSKKYRNFDIPSEYTGVRRYLQNAYARDEFINTCAADKEI 230
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: clic3 (chloride intracellular channel protein 4-like [Source:NCBI gene;Acc:103028884])

HSP 1 Score: 66.2402 bits (160), Expect = 3.011e-12
Identity = 65/244 (26.64%), Postives = 97/244 (39.75%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAAD-ILKSLNILLKTKN-------EKPLITILTRIDIFL--------------GSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDII 721
            P +ELF+K S  D E  G+CP  Q  FM  ++    K ++  +T V+M+   E    L    + P         T    +   + ET               L  P Y P++    K  N A D I    +  +K  N       EK  +  L ++D +L                 S + L  D +T  DC L+P+L  V+V  R+   F IP  L  L RY++  Y +  F  TC  D +I+
Sbjct:    5 PKVELFIKAS-DDGEGVGNCPFCQRLFMILWL----KGVNFTLTTVDMKRAPEVLKDLAPGSQPPFLIYNGEVRTDTNKIEEFLEET---------------LAPPQY-PKLCCRYKESNRAGDDIFHKFSAYIKNPNPGLNDMLEKKFLRSLMKLDQYLLTPLPCELDKNPDASQSSRQYLDGDSLTLADCNLLPKLHIVKVVCRKYRDFVIPEALVGLTRYLEKAYQQDEFRYTCPNDAEIL 227
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Match: clic5b (chloride intracellular channel 5b [Source:ZFIN;Acc:ZDB-GENE-040426-2542])

HSP 1 Score: 64.6994 bits (156), Expect = 1.273e-11
Identity = 62/241 (25.73%), Postives = 101/241 (41.91%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFY---VLVENKLIDLRVTPVNMEMQCES----YLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P IELFVK    D E  G+CP +Q  FM  +   V+     +DL+  P ++          +L  N   +  + K    T +S +    L A+  +     I IF   + +        A  +N   D  + L        EK L   L ++D +L S                 S K L  +E+T  DC L+P+L  V+V  ++  +++IP ++  + RY+   Y  + F  TC+ D +I
Sbjct:   13 PDIELFVKAG-SDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGEVKTDINK----TRSSWRRYPKLAAKHRESNTAGIDIF--AKFS--------AYIKNTRPDANRGL--------EKSLTKALWKLDEYLNSPLPDEIDANSMEEEKSSSRKFLDGNELTLADCNLLPKLHIVKVVAKKYRNYNIPSDMTAVWRYLNSAYAREEFTNTCAADIEI 230
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Sea Lamprey
Match: clic2 (chloride intracellular channel 2 [Source:ZFIN;Acc:ZDB-GENE-040718-299])

HSP 1 Score: 68.1662 bits (165), Expect = 1.437e-13
Identity = 62/245 (25.31%), Postives = 94/245 (38.37%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNE----------KPLITILTRIDIFLGSK-----------STKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEE 736
            P IELFVK    D E  G+CP+ Q  FM  ++    K +   VT V+M  +      L    + P         T    +   + ET            CP    P    +   +    AD+    +  +K  +           K L+  L R+D +L                K L  +++T  DC L+P+L  V+V  +    FDIP  L  +  Y+K+ Y +  F  TC  DR+I   + E
Sbjct:   15 PSIELFVKAG-SDGETIGNCPLCQRIFMVLWL----KGVTFNVTTVDMTKKPAILRSLAPGSQPPFLTFNGDVRTDFIKIEEFLEETL-----------CPP-RYPSLGVKYQSSYKAGADVFSRFSAYIKNSSATDNGSDNYLMKNLLKALKRLDDYLKEPLPYEENSSDVTERKFLDGNQLTLADCDLLPKLHIVKVVCKRYRGFDIPEQLMGIWHYLKNAYAQDEFMRTCPADREIELAYAE 242
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Sea Lamprey
Match: clic6 (chloride intracellular channel 6 [Source:ZFIN;Acc:ZDB-GENE-121214-172])

HSP 1 Score: 60.8474 bits (146), Expect = 4.530e-11
Identity = 57/242 (23.55%), Postives = 93/242 (38.43%), Query Frame = 2 
Query:   71 IELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAK--AENLAA-DILKSLNILLKTKN-------EKPLITILTRIDIFL----------------GSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            +EL V+    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P         T    +   + E               QL+ P Y    A+    NLA  D+    +  +K          EK L+    ++D +L                G    K L  DE+T  DC L+P+L  V++  ++   F+IP  +  + +Y++  Y    F  TC  DR+I
Sbjct:    8 LELRVRAG-SDGESIGNCPFSQRLFMILWL----KGVVFNVTTVDIKRKPPELQNLAPGTHPPFLTFNGEVKTDVNKIEEFLEE---------------QLSPPNYVRLAARHRESNLAGNDVFAKFSAYIKNAKKEANDNLEKALLKAFKKLDDYLLSPLPEEIDDCSMGDDGISPRKFLDGDELTLADCNLLPKLHIVKIVAKKYRDFEIPAEMTGVWKYLRGAYARDEFTNTCPADREI 229
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Nematostella
Match: EDO38693 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC76])

HSP 1 Score: 48.9062 bits (115), Expect = 7.616e-7
Identity = 33/88 (37.50%), Postives = 47/88 (53.41%), Query Frame = 2 
Query:  458 TKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDII 721
            TK E  L   L  +D  L S+ T+ + SD +T+ D  L+P L  +RVAG +   F IP  LK++  YI+     +VF+ T   D  II
Sbjct:  124 TKAEDTLKLHLEILDKLLASRKTRFVESDSLTFVDSYLLPILLVIRVAGAK-KGFQIPATLKNVRLYIEEGDKSQVFQETRPTDSSII 210
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: ENSORLT00000013178.2 (chloride intracellular channel protein 4 [Source:NCBI gene;Acc:101172747])

HSP 1 Score: 76.6406 bits (187), Expect = 8.034e-16
Identity = 70/245 (28.57%), Postives = 111/245 (45.31%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAA-DILKSLNILLKTKN-------EKPLITILTRIDIFL-------------GSKSTKLLM-SDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHE 733
            P IELFVK SL D E  G+CP  Q  FM  ++    K  +  +T V+M+   E    L    + P         T     TN I E    LE+ +     P+L          K  NLA  DI +  +  +K  N       EK  ++ L +++++L              ++S++L +  +  T  DC L+P+L  V+V  ++  +FDIP  LK L RY+ + Y +  F  TC +D +I+  ++
Sbjct:   20 PNIELFVKASL-DAESVGNCPFCQRLFMILWL----KRAEFVLTTVDMKRAPEVLKALAPGSQPPFLIFNGEVKTD----TNKIEEF---LEEKLAPPRYPKLCC------TYKESNLAGEDIFRKFSAYIKNPNPGLNIMLEKQFLSTLVKLNMYLETPLPHELERNPDANESSRLYLDGNAFTLADCNLLPKLNIVKVVCKKYRNFDIPTELKGLTRYLDNAYKQDEFRHTCPQDEEILLAYK 246
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: ENSORLT00000037696.1 (chloride intracellular channel protein 4 [Source:NCBI gene;Acc:101172747])

HSP 1 Score: 76.6406 bits (187), Expect = 8.322e-16
Identity = 70/245 (28.57%), Postives = 111/245 (45.31%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAA-DILKSLNILLKTKN-------EKPLITILTRIDIFL-------------GSKSTKLLM-SDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHE 733
            P IELFVK SL D E  G+CP  Q  FM  ++    K  +  +T V+M+   E    L    + P         T     TN I E    LE+ +     P+L          K  NLA  DI +  +  +K  N       EK  ++ L +++++L              ++S++L +  +  T  DC L+P+L  V+V  ++  +FDIP  LK L RY+ + Y +  F  TC +D +I+  ++
Sbjct:    5 PNIELFVKASL-DAESVGNCPFCQRLFMILWL----KRAEFVLTTVDMKRAPEVLKALAPGSQPPFLIFNGEVKTD----TNKIEEF---LEEKLAPPRYPKLCC------TYKESNLAGEDIFRKFSAYIKNPNPGLNIMLEKQFLSTLVKLNMYLETPLPHELERNPDANESSRLYLDGNAFTLADCNLLPKLNIVKVVCKKYRNFDIPTELKGLTRYLDNAYKQDEFRHTCPQDEEILLAYK 231
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: clic4 (chloride intracellular channel 4 [Source:NCBI gene;Acc:101159958])

HSP 1 Score: 71.633 bits (174), Expect = 4.372e-14
Identity = 64/243 (26.34%), Postives = 98/243 (40.33%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQ--LTLPIYDPEVAKAENLAADILKSLNILLKTKN-------EKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDI 718
            P+IELFVK    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P         T      N I E  +D+        CP   + L    PE   A     DI    +  +K          E+ L+  L ++D +L +                   K L  DE+T  DC L+P+L  V+V  R+   FDIP  +  + +Y+ + Y  + F  TC  D++I
Sbjct:   16 PIIELFVKAG-SDGESIGNCPFSQRLFMILWL----KGVVFNVTTVDLKRKPADLQNLAPGTHPPFITFNGEVKTD----VNKIEEFLEDVL-------CPPKFIKLGARHPESNTA---GMDIFAKFSAFIKNSKPDANEALERGLLKTLQKLDEYLRTPLPDEIDHNSIEDVKVSGRKFLDGDEMTLADCNLLPKLHIVKVVARKYRGFDIPKEMTAIWKYLNNAYTREEFINTCPSDKEI 239
[Close]
BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: clic5b (chloride intracellular channel protein 5 [Source:NCBI gene;Acc:101162647])

HSP 1 Score: 70.4774 bits (171), Expect = 1.261e-13
Identity = 64/249 (25.70%), Postives = 104/249 (41.77%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVA---KAENLAA-DILKSLNILLKTKN-------EKPLITILTRIDIFLGS--------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEE 736
            P IELFVK    D E  G+CP +Q  FM  ++    K +   VT V+++ +      L      P    +    T            T+ +E+ +    CP    P Y P++A   +  N A  DI    +  +K          EK L   L ++D +L S               S   L  +E+T  DC L+P+L  V+V  ++  ++DIP ++K + RY+   Y    F  TC+   +I   +++
Sbjct:    8 PDIELFVKAG-SDGESVGNCPFSQRLFMILWL----KGVVFNVTTVDLKRKPTDLHNLAPGTHPPFLTFDGEVRTD-----------TNKIEEFLEATLCP----PKY-PKLAARHRESNTAGNDIFAKFSAFIKNTKPEANDALEKGLTKALKKLDDYLNSPLPGEADANDSEEGSSRSFLDGNELTLADCNLLPKLHIVKVVAKKYRNYDIPADMKGVWRYLNKAYARDEFTNTCADTTEIETAYKD 235
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BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Match: clic2 (chloride intracellular channel 2 [Source:NCBI gene;Acc:101162375])

HSP 1 Score: 68.9366 bits (167), Expect = 3.996e-13
Identity = 64/254 (25.20%), Postives = 108/254 (42.52%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTK-----NEKPLITILTRIDIFLGS----------------KSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRR 763
            P+IELFVK   +D E+ G+CP  Q  FM  ++    K +   VT V+M  +      L      P   + +GT      L     +  + LE+ +     P L+     P+  ++ ++ ADI    +  +K        +K L+    R+D +L S                 + K L  + +T  DC L+P+L  + VA ++   FDIP +   + RY+++    + F  TC  D +I   +    S   NR+
Sbjct:   11 PIIELFVKAG-HDGENVGNCPFCQRLFMVLWL----KGVKFTVTTVDMRKKPAELKDLAPGTNPPFL-LYNGT------LKTDFIKIEEFLEQTLAPPRYPHLS-----PQNKESFDVGADIFAKFSAFIKNSPNNAVQKKNLLKEFKRLDDYLNSPLPEEIDHHSTETISTSNRKFLDGNRLTLADCNLLPKLHVIMVASKKYCDFDIPAHFTGVWRYLQNASEREEFVQTCPADIEIEKAY---FSVANNRK 244
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BLAST of Chloride intracellular channel 4 vs. Planmine SMEST
Match: SMESG000070758.1 (SMESG000070758.1)

HSP 1 Score: 523.857 bits (1348), Expect = 0.000e+0
Identity = 256/256 (100.00%), Postives = 256/256 (100.00%), Query Frame = 2 
Query:   59 MIPVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLTKDDSKLLTIDITDPDIQ 826
            MIPVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLTKDDSKLLTIDITDPDIQ
Sbjct:    1 MIPVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLTKDDSKLLTIDITDPDIQ 256
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BLAST of Chloride intracellular channel 4 vs. Planmine SMEST
Match: SMESG000054543.1 (SMESG000054543.1)

HSP 1 Score: 200.29 bits (508), Expect = 1.385e-62
Identity = 102/241 (42.32%), Postives = 152/241 (63.07%), Query Frame = 2 
Query:   62 IPVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKV-ESGTSTSGKDLTNLIAETTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLTKD 781
            +P+IELFVK S  D  D G CPI+Q WFMA+Y LVEN+LI+LRVTPV+++   + YL+LNV R LPVA V E     +G+D+ +LIA+  D++E L+  F CP L L       A A  +  D+ ++ N  L+T N   ++  L  ++ F+ ++S K L  D+V++ DC++MP+LQH+R+A  E  +F IP   K L +Y++ MY  K F ++C  DRDII  + EK +  + + S L +D
Sbjct:    8 LPIIELFVKSSPVDPADKGPCPISQKWFMAYYTLVENQLINLRVTPVDIKNPPQEYLKLNVGRHLPVALVIEGKHPMTGEDMADLIADNDDEIENLMDKFKCPGLEL------GATAFKVTEDLFRNFNSYLQTNNSTNMLANLASLNDFIENRSNKYLQGDQVSFVDCVVMPKLQHLRIACAEFKNFQIPTEFKGLWKYLETMYETKAFMISCPCDRDIIIHYSEK-TNPRPKSSFLLRD 241
[Close]
BLAST of Chloride intracellular channel 4 vs. Planmine SMEST
Match: SMESG000007126.1 (SMESG000007126.1)

HSP 1 Score: 134.42 bits (337), Expect = 3.559e-37
Identity = 82/235 (34.89%), Postives = 128/235 (54.47%), Query Frame = 2 
Query:   65 PVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNMEMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAE--------TTDDLEKLIMIFNCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIFLGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRYIKHMYLEKVFEVTCSKDRDIIAQHEEKVS 745
            P++EL+VK S  + +D GSCPI QTWFM  Y LV+   IDL+VTPVN++  C SY QL + R+LPV K+      SGK+L +  +E        + ++L +L+  +    L       ++ +AE    D+ +   I L T N       L ++D +    ++K L+ D ++  DC LMP+LQH+R+    L   D+  NL H+  YI  MY  + F  +C  DR+II  + + ++
Sbjct:    4 PLLELYVKTSSCE-DDIGSCPICQTWFMILYQLVDENFIDLQVTPVNVDNPCNSYKQLGMGRKLPVVKI-----ISGKELIDCQSEIVRKNFIFSGNELYELLKSWKSKLLNEN--SIKIHEAEFSFLDLYRDFKIFLTTNNFNKFHYYLKKLDDYFTICNSKFLVGDFISICDCELMPKLQHIRITCILLKEIDVFENLDHIKTYINKMYSVEAFIQSCPSDRNIILHYRDTLN 230
The following BLAST results are available for this feature:
BLAST of Chloride intracellular channel 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CLIC43.537e-1424.48chloride intracellular channel 4 [Source:HGNC Symb... [more]
CLIC43.537e-1424.48chloride intracellular channel 4 [Source:HGNC Symb... [more]
CLIC25.129e-1427.43chloride intracellular channel 2 [Source:HGNC Symb... [more]
CLIC15.884e-1425.70chloride intracellular channel 1 [Source:HGNC Symb... [more]
CLIC15.884e-1425.70chloride intracellular channel 1 [Source:HGNC Symb... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
exc-42.540e-2027.41Chloride intracellular channel exc-4 [Source:UniP... [more]
exl-11.314e-1730.66Chloride intracellular channel exl-1 [Source:UniP... [more]
exl-11.314e-1730.66Chloride intracellular channel exl-1 [Source:UniP... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Clic2.421e-2832.55gene:FBgn0030529 transcript:FBtr0346089[more]
Clic2.421e-2832.55gene:FBgn0030529 transcript:FBtr0073835[more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
clic22.407e-1526.38chloride intracellular channel 2 [Source:ZFIN;Acc:... [more]
clic22.407e-1526.38chloride intracellular channel 2 [Source:ZFIN;Acc:... [more]
clic22.407e-1526.38chloride intracellular channel 2 [Source:ZFIN;Acc:... [more]
pnpla7a9.758e-1428.10patatin-like phospholipase domain containing 7a [S... [more]
clic39.758e-1428.10chloride intracellular channel 3 [Source:ZFIN;Acc:... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
st3gal57.594e-1325.00ST3 beta-galactoside alpha-2,3-sialyltransferase 5... [more]
clic12.210e-1225.10chloride intracellular channel 1 [Source:NCBI gene... [more]
clic41.190e-1123.17chloride intracellular channel 5 [Source:NCBI gene... [more]
st3gal52.287e-1023.36ST3 beta-galactoside alpha-2,3-sialyltransferase 5... [more]
CLIC62.498e-1021.55chloride intracellular channel 6 [Source:NCBI gene... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Clic48.291e-1524.48chloride intracellular channel 4 (mitochondrial) [... [more]
Clic53.250e-1426.14chloride intracellular channel 5 [Source:MGI Symbo... [more]
Clic16.813e-1425.50chloride intracellular channel 1 [Source:MGI Symbo... [more]
Clic55.659e-1225.40chloride intracellular channel 5 [Source:MGI Symbo... [more]
Clic62.043e-1126.78chloride intracellular channel 6 [Source:MGI Symbo... [more]
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BLAST of Chloride intracellular channel 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8WQA4|EXC4_CAEEL3.231e-1927.41Chloride intracellular channel exc-4 OS=Caenorhabd... [more]
sp|O45405|EXL1_CAEEL1.672e-1630.66Chloride intracellular channel exl-1 OS=Caenorhabd... [more]
sp|Q9XSA7|CLIC4_BOVIN2.694e-1423.77Chloride intracellular channel protein 4 OS=Bos ta... [more]
sp|Q5R957|CLIC4_PONAB5.525e-1423.77Chloride intracellular channel protein 4 OS=Pongo ... [more]
sp|Q9QYB1|CLIC4_MOUSE5.800e-1424.48Chloride intracellular channel protein 4 OS=Mus mu... [more]
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BLAST of Chloride intracellular channel 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8GES92.172e-6644.31Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8GET56.266e-6644.31Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8G1697.862e-6644.31Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A267GVZ36.732e-5945.27Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8G6K17.260e-5945.27Uncharacterized protein OS=Macrostomum lignano OX=... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
clic22.985e-1325.49chloride intracellular channel 2 [Source:NCBI gene... [more]
clic49.764e-1325.51chloride intracellular channel 4 [Source:NCBI gene... [more]
clic5a1.184e-1225.73chloride intracellular channel 5 [Source:NCBI gene... [more]
clic33.011e-1226.64chloride intracellular channel protein 4-like [Sou... [more]
clic5b1.273e-1125.73chloride intracellular channel 5b [Source:ZFIN;Acc... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2
Match NameE-valueIdentityDescription
clic21.437e-1325.31chloride intracellular channel 2 [Source:ZFIN;Acc:... [more]
clic64.530e-1123.55chloride intracellular channel 6 [Source:ZFIN;Acc:... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Chloride intracellular channel 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO386937.616e-737.50Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Chloride intracellular channel 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSORLT00000013178.28.034e-1628.57chloride intracellular channel protein 4 [Source:N... [more]
ENSORLT00000037696.18.322e-1628.57chloride intracellular channel protein 4 [Source:N... [more]
clic44.372e-1426.34chloride intracellular channel 4 [Source:NCBI gene... [more]
clic5b1.261e-1325.70chloride intracellular channel protein 5 [Source:N... [more]
clic23.996e-1325.20chloride intracellular channel 2 [Source:NCBI gene... [more]
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BLAST of Chloride intracellular channel 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000070758.10.000e+0100.00SMESG000070758.1[more]
SMESG000054543.11.385e-6242.32SMESG000054543.1[more]
SMESG000007126.13.559e-3734.89SMESG000007126.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30029485 ID=SMED30029485|Name=Chloride intracellular channel 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1016bp
TATAATCAAAAAAAGTTGAATTAATTTTCATAATTATAGTTTTACATCAT
TTTAAAAAATGATTCCAGTTATAGAGCTTTTCGTTAAGTGTTCTTTGTAT
GATAAAGAGGATTTCGGATCATGTCCAATAAATCAAACATGGTTTATGGC
ATTTTATGTGTTAGTGGAAAACAAATTAATCGACCTTCGAGTAACCCCGG
TCAACATGGAAATGCAATGTGAAAGCTATTTGCAATTAAATGTCAGCCGG
AGACTGCCAGTAGCCAAAGTTGAAAGTGGAACATCAACCTCTGGAAAGGA
TTTAACCAACTTAATCGCCGAAACAACTGACGACTTGGAGAAATTAATTA
TGATTTTCAACTGTCCTCAGCTCACATTGCCGATCTACGATCCGGAAGTT
GCTAAAGCAGAAAATCTCGCAGCCGACATTTTAAAATCACTGAATATTTT
ATTGAAAACTAAAAACGAAAAACCTTTAATAACCATTTTAACTAGAATCG
ACATATTTTTAGGTTCGAAATCCACAAAGTTATTAATGAGCGATGAAGTG
ACATATGGAGATTGTATTTTGATGCCGAGATTACAACACGTTCGAGTTGC
AGGACGTGAGCTTGCGTCGTTTGATATTCCATTTAATCTGAAACATCTTA
TTCGATATATCAAACATATGTACTTAGAAAAGGTTTTCGAAGTCACCTGT
TCGAAGGATCGAGATATTATTGCTCAGCACGAAGAGAAAGTTTCCACTGG
GAAAAACCGACGCAGTTTATTGACGAAAGACGATTCTAAACTGTTGACAA
TTGATATAACTGATCCAGATATTCAATAAAGTTTTCAATACCGTTGATCA
ACTCATTATTTGACAGAATTCATTTTCTTATCATGTGGAACTATATTCAG
CAACTTCTAGAACTGTATGACTATCATGGACGACTTACCATCTGATATTT
ATTGTCGTTTTTTAACTAGTAAAATTGTATTTAAGTATAATTCTAAAATA
ACTATTTTCAACAGAT
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protein sequence of SMED30029485-orf-1

>SMED30029485-orf-1 ID=SMED30029485-orf-1|Name=SMED30029485-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=257bp
MIPVIELFVKCSLYDKEDFGSCPINQTWFMAFYVLVENKLIDLRVTPVNM
EMQCESYLQLNVSRRLPVAKVESGTSTSGKDLTNLIAETTDDLEKLIMIF
NCPQLTLPIYDPEVAKAENLAADILKSLNILLKTKNEKPLITILTRIDIF
LGSKSTKLLMSDEVTYGDCILMPRLQHVRVAGRELASFDIPFNLKHLIRY
IKHMYLEKVFEVTCSKDRDIIAQHEEKVSTGKNRRSLLTKDDSKLLTIDI
TDPDIQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
Vocabulary: INTERPRO
TermDefinition
IPR036249Thioredoxin-like_sf
IPR036282Glutathione-S-Trfase_C_sf
IPR010987Glutathione-S-Trfase_C-like
IPR012336Thioredoxin-like_fold
Vocabulary: molecular function
TermDefinition
GO:0004602glutathione peroxidase activity
GO:0005244voltage-gated ion channel activity
GO:0005254chloride channel activity
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
GO:0005634nucleus
GO:0005737cytoplasm
GO:0016020membrane
GO:0016021integral component of membrane
GO:0034707chloride channel complex
Vocabulary: biological process
TermDefinition
GO:0006810transport
GO:0006811ion transport
GO:0006821chloride transport
GO:0007165signal transduction
GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0034765regulation of ion transmembrane transport
GO:0060315negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0098869cellular oxidant detoxification
GO:1902476chloride transmembrane transport
GO:0051099positive regulation of binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:1.20.1050.10coord: 103..255
e-value: 9.3E-30
score: 105.6
NoneNo IPR availablePANTHERPTHR43920FAMILY NOT NAMEDcoord: 3..236
NoneNo IPR availablePANTHERPTHR43920:SF5CHLORIDE INTRACELLULAR CHANNEL, ISOFORM Acoord: 3..236
IPR036249Thioredoxin-like superfamilyGENE3DG3DSA:3.40.30.10coord: 1..93
e-value: 4.9E-17
score: 64.0
IPR036282Glutathione S-transferase, C-terminal domain superfamilySUPERFAMILYSSF47616GST C-terminal domain-likecoord: 135..225