MICOS complex subunit MIC10

Overview


Name	MICOS complex subunit MIC10
Smed ID	SMED30029473
Length (bp)	479

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of MICOS complex subunit MIC10 (SMED30029473) t-SNE clustered cells

Violin plots show distribution of expression levels for MICOS complex subunit MIC10 (SMED30029473) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of MICOS complex subunit MIC10 (SMED30029473) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for MICOS complex subunit MIC10 (SMED30029473) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30029473

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
X1 cell	SMED30029473	SMESG000039213.1	SmedASXL_006271	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Human
Match: MICOS10 (mitochondrial contact site and cristae organizing system subunit 10 [Source:HGNC Symbol;Acc:HGNC:32068])

HSP 1 Score: 65.4698 bits (158), Expect = 3.208e-14
Identity = 37/74 (50.00%), Postives = 50/74 (67.57%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQ 280
            + ELG K DRC++D  +K   G G+G+V S+ FFKRR  PL FGS +GLGMA +NC +D + P  L+ GK  K+
Sbjct:    3 ESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDFQAPY-LLHGKYVKE 75

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Human
Match: MICOS10-NBL1 (MICOS10-NBL1 readthrough [Source:HGNC Symbol;Acc:HGNC:48338])

HSP 1 Score: 58.9214 bits (141), Expect = 6.743e-12
Identity = 34/69 (49.28%), Postives = 46/69 (66.67%), Query Frame = 2

Query:   77 KIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQS 283
            K DRC++D  +K   G G+G+V S+ FFKRR  PL FGS +GLGMA +NC +D + P  L+ GK  K+ 
Sbjct:    2 KWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDFQAPY-LLHGKYVKEQ 69

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Human
Match: MICOS10 (mitochondrial contact site and cristae organizing system subunit 10 [Source:HGNC Symbol;Acc:HGNC:32068])

HSP 1 Score: 51.9878 bits (123), Expect = 2.711e-9
Identity = 28/74 (37.84%), Postives = 38/74 (51.35%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQ 280
            + ELG K DRC++D  +K                  R  PL FGS +GLGMA +NC +D + P  L+ GK  K+
Sbjct:    3 ESELGRKWDRCLADAVVKI----------------GRMWPLAFGSGMGLGMAYSNCQHDFQAPY-LLHGKYVKE 59

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Human
Match: MICOS10-NBL1 (MICOS10-NBL1 readthrough [Source:HGNC Symbol;Acc:HGNC:48338])

HSP 1 Score: 50.0618 bits (118), Expect = 1.738e-8
Identity = 23/42 (54.76%), Postives = 29/42 (69.05%), Query Frame = 2

Query:  155 FFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQ 280
            FFKRR  PL FGS +GLGMA +NC +D + P  L+ GK  K+
Sbjct:   27 FFKRRMWPLAFGSGMGLGMAYSNCQHDFQAPY-LLHGKYVKE 67

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Celegans
Match: F54A3.5 (MICOS complex subunit Mic10 [Source:UniProtKB/Swiss-Prot;Acc:Q9N4K0])

HSP 1 Score: 59.6918 bits (143), Expect = 3.031e-12
Identity = 31/66 (46.97%), Postives = 42/66 (63.64%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSL 256
            ++E+G KIDRC +D  +K   G  +G+VASV FFK R  P+ FGS +GLG   +NC +D   P  L
Sbjct:   14 EDEVGQKIDRCFADSLLKVTGGVAIGIVASVAFFKSRSWPIWFGSGVGLGTGWSNCRHDFASPYVL 79

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Fly
Match: CG12479 (gene:FBgn0040871 transcript:FBtr0073869)

HSP 1 Score: 46.595 bits (109), Expect = 2.140e-7
Identity = 23/65 (35.38%), Postives = 39/65 (60.00%), Query Frame = 2

Query:   44 MSAKIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDL 238
            MS   ++ L   I+RC+SD  +K + G  +G V +++FF+RR  P+  G+  G+G+A   C  +L
Sbjct:    1 MSTTPEDRLRENINRCLSDSLVKGVGGLVIGSVVTLLFFRRRIWPVWLGTGFGVGVAYRGCEKEL 65

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Zebrafish
Match: micos10 (mitochondrial contact site and cristae organizing system subunit 10 [Source:ZFIN;Acc:ZDB-GENE-060825-325])

HSP 1 Score: 61.6178 bits (148), Expect = 5.546e-13
Identity = 34/66 (51.52%), Postives = 46/66 (69.70%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSL 256
            ++ELG K DRC++D  IK   G G+G+V SV+FFKRR  P+  G+ +GLGMA +NC NDL+    L
Sbjct:    3 EKELGQKWDRCLADCAIKVGTGLGLGIVFSVVFFKRRTSPIALGTGIGLGMAYSNCQNDLRSHYQL 68

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Mouse
Match: Micos10 (mitochondrial contact site and cristae organizing system subunit 10 [Source:MGI Symbol;Acc:MGI:1913628])

HSP 1 Score: 63.5438 bits (153), Expect = 8.714e-14
Identity = 37/74 (50.00%), Postives = 50/74 (67.57%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQ 280
            + ELG K DRC++D  +K   G G+G+V S+ FFKRR  PL FGS +GLGMA +NC +D + P  L+ GK  K+
Sbjct:    3 ESELGRKWDRCMADTVVKLGTGFGLGIVFSLTFFKRRMWPLAFGSGVGLGMAYSNCQHDFQAPY-LLHGKYVKE 75

[Close]

BLAST of MICOS complex subunit MIC10 vs. UniProt/SwissProt
Match: sp|Q5TGZ0|MIC10_HUMAN (MICOS complex subunit MIC10 OS=Homo sapiens OX=9606 GN=MICOS10 PE=1 SV=1)

HSP 1 Score: 65.4698 bits (158), Expect = 1.540e-13
Identity = 37/74 (50.00%), Postives = 50/74 (67.57%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQ 280
            + ELG K DRC++D  +K   G G+G+V S+ FFKRR  PL FGS +GLGMA +NC +D + P  L+ GK  K+
Sbjct:    3 ESELGRKWDRCLADAVVKIGTGFGLGIVFSLTFFKRRMWPLAFGSGMGLGMAYSNCQHDFQAPY-LLHGKYVKE 75

[Close]

BLAST of MICOS complex subunit MIC10 vs. UniProt/SwissProt
Match: sp|Q7TNS2|MIC10_MOUSE (MICOS complex subunit Mic10 OS=Mus musculus OX=10090 GN=Micos10 PE=1 SV=1)

HSP 1 Score: 63.5438 bits (153), Expect = 6.096e-13
Identity = 37/74 (50.00%), Postives = 50/74 (67.57%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQ 280
            + ELG K DRC++D  +K   G G+G+V S+ FFKRR  PL FGS +GLGMA +NC +D + P  L+ GK  K+
Sbjct:    3 ESELGRKWDRCMADTVVKLGTGFGLGIVFSLTFFKRRMWPLAFGSGVGLGMAYSNCQHDFQAPY-LLHGKYVKE 75

[Close]

BLAST of MICOS complex subunit MIC10 vs. UniProt/SwissProt
Match: sp|B2RYW8|MIC10_RAT (MICOS complex subunit Mic10 OS=Rattus norvegicus OX=10116 GN=Micos10 PE=3 SV=1)

HSP 1 Score: 62.7734 bits (151), Expect = 1.249e-12
Identity = 36/74 (48.65%), Postives = 49/74 (66.22%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQ 280
            + E G K DRC++D  +K   G G+G+V S+ FFKRR  PL FGS +GLGMA +NC +D + P  L+ GK  K+
Sbjct:    3 ESEPGRKWDRCMADALVKLGTGFGLGMVFSLTFFKRRKWPLAFGSGVGLGMAYSNCQHDFQAPY-LLHGKYVKE 75

[Close]

BLAST of MICOS complex subunit MIC10 vs. UniProt/SwissProt
Match: sp|Q9N4K0|MIC10_CAEEL (MICOS complex subunit Mic10 OS=Caenorhabditis elegans OX=6239 GN=F54A3.5 PE=3 SV=2)

HSP 1 Score: 59.6918 bits (143), Expect = 3.856e-11
Identity = 31/66 (46.97%), Postives = 42/66 (63.64%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSL 256
            ++E+G KIDRC +D  +K   G  +G+VASV FFK R  P+ FGS +GLG   +NC +D   P  L
Sbjct:   14 EDEVGQKIDRCFADSLLKVTGGVAIGIVASVAFFKSRSWPIWFGSGVGLGTGWSNCRHDFASPYVL 79

[Close]

BLAST of MICOS complex subunit MIC10 vs. TrEMBL
Match: Q5BSC7 (MICOS complex subunit MIC10 OS=Schistosoma japonicum OX=6182 GN=EWB00_004079 PE=2 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 1.046e-17
Identity = 45/73 (61.64%), Postives = 54/73 (73.97%), Query Frame = 2

Query:   53 KIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKI 271
            K ++ LG K+DRCISD  IKT  G   G++ SV+F KRRP PLIFG+  GLGM I+NCNND KQPL LVS +I
Sbjct:    6 KSEDILGFKLDRCISDTLIKTGAGLFGGIIFSVVFAKRRPWPLIFGTGFGLGMGISNCNNDFKQPLPLVSHRI 78

[Close]

BLAST of MICOS complex subunit MIC10 vs. TrEMBL
Match: A0A183BGC3 (MICOS complex subunit MIC10 OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS18258 PE=3 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 1.313e-17
Identity = 45/80 (56.25%), Postives = 60/80 (75.00%), Query Frame = 2

Query:   47 SAKIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQSI 286
            SAK ++ LG+++DRCISD  IKT  GA +G++ SV+  K +P P++FG+ LGLGM+IANCNND KQPL LVS +I   S 
Sbjct:    4 SAKSEDILGLRLDRCISDTLIKTGSGAFMGIIFSVLLAKSKPWPVVFGTGLGLGMSIANCNNDFKQPLPLVSHRIKVSSF 83

[Close]

BLAST of MICOS complex subunit MIC10 vs. TrEMBL
Match: C1LK15 (MICOS complex subunit MIC10 OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 80.8777 bits (198), Expect = 5.364e-17
Identity = 44/70 (62.86%), Postives = 52/70 (74.29%), Query Frame = 2

Query:   53 KIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVS 262
            K ++ LG K+DRCISD  IKT  G   G++ SV+F KRRP PLIFG+  GLGM I+NCNND KQPL LVS
Sbjct:    6 KSEDILGFKLDRCISDTLIKTGAGLFGGIIFSVVFAKRRPWPLIFGTGFGLGMGISNCNNDFKQPLPLVS 75

[Close]

BLAST of MICOS complex subunit MIC10 vs. TrEMBL
Match: A0A146MHV0 (MICOS complex subunit MIC10 OS=Schistosoma mansoni OX=6183 GN=c797_g1_i1 PE=3 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 8.806e-17
Identity = 44/73 (60.27%), Postives = 53/73 (72.60%), Query Frame = 2

Query:   53 KIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKI 271
            K ++ LG K+DRCISD  IKT  G   G++ SV+  KRRP PLIFG+  GLGM I+NCNND KQPL LVS +I
Sbjct:    6 KSEDILGFKLDRCISDTLIKTGAGLFGGIIFSVVLAKRRPWPLIFGTGFGLGMGISNCNNDFKQPLPLVSHRI 78

[Close]

BLAST of MICOS complex subunit MIC10 vs. TrEMBL
Match: A0A146MGH5 (MICOS complex subunit MIC10 OS=Schistosoma mansoni OX=6183 GN=c797_g1_i2 PE=3 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 9.370e-17
Identity = 44/73 (60.27%), Postives = 53/73 (72.60%), Query Frame = 2

Query:   53 KIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKI 271
            K ++ LG K+DRCISD  IKT  G   G++ SV+  KRRP PLIFG+  GLGM I+NCNND KQPL LVS +I
Sbjct:    6 KSEDILGFKLDRCISDTLIKTGAGLFGGIIFSVVLAKRRPWPLIFGTGFGLGMGISNCNNDFKQPLPLVSHRI 78

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Cavefish
Match: ENSAMXT00000030462.1 (pep primary_assembly:Astyanax_mexicanus-2.0:22:18042672:18051540:1 gene:ENSAMXG00000040088.1 transcript:ENSAMXT00000030462.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 68.9366 bits (167), Expect = 7.413e-16
Identity = 35/65 (53.85%), Postives = 47/65 (72.31%), Query Frame = 2

Query:   62 EELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSL 256
            E+ G K DRC+SD  +KT++G GVG + SV+FFKRR  P+ FG+ +GLGMA +NC +D K P  L
Sbjct:    2 EDSGRKWDRCVSDSAVKTVLGLGVGALFSVLFFKRRSWPIAFGAGMGLGMAYSNCQHDFKSPYLL 66

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Cavefish
Match: micos10 (MICOS complex subunit MIC10 [Source:NCBI gene;Acc:103047888])

HSP 1 Score: 65.855 bits (159), Expect = 1.141e-14
Identity = 37/74 (50.00%), Postives = 50/74 (67.57%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQ 280
            ++ELG K DRC++D  IK   G G+G+V SV+FFKRR  P+ FG+  GLGMA +NC NDL+ P  + S    +Q
Sbjct:    3 EKELGQKWDRCLADAAIKVGAGLGLGIVFSVVFFKRRTFPIAFGTGTGLGMAYSNCQNDLRSPYLVHSNATKEQ 76

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Medaka
Match: ENSORLT00000035437.1 (pep primary_assembly:ASM223467v1:7:1586357:1587485:1 gene:ENSORLG00000024698.1 transcript:ENSORLT00000035437.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 66.6254 bits (161), Expect = 6.190e-15
Identity = 41/83 (49.40%), Postives = 52/83 (62.65%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQSILELAQTT 307
            + ELG K+DRC++DG IK   G G+G+V SV+FFKR   P+ FGS  GLGMA ANC NDL+    L     H+   + LA  T
Sbjct:    3 ERELGRKLDRCLADGVIKLGTGLGLGIVFSVLFFKRHAWPISFGSGAGLGMAYANCQNDLRWHYLL-----HRNPKVALADET 80

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Medaka
Match: ENSORLT00000027538.1 (mitochondrial contact site and cristae organizing system subunit 10 [Source:NCBI gene;Acc:101167281])

HSP 1 Score: 65.0846 bits (157), Expect = 1.274e-13
Identity = 37/78 (47.44%), Postives = 52/78 (66.67%), Query Frame = 2

Query:   53 KIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQSI 286
            K+ +E G K DRC++D  +KT+ G GVGVV SV+F KRR  P+ FGS LGLGM  +NC +D + P      +IH +++
Sbjct:   77 KMADEYGRKWDRCLADTAVKTVTGLGVGVVFSVLFLKRRTWPVSFGSGLGLGMGYSNCQHDFRLPY-----RIHGRTV 149

[Close]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Medaka
Match: ENSORLT00000029141.1 (pep primary_assembly:ASM223467v1:7:1586357:1587485:1 gene:ENSORLG00000024698.1 transcript:ENSORLT00000029141.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 51.6026 bits (122), Expect = 2.630e-9
Identity = 31/83 (37.35%), Postives = 39/83 (46.99%), Query Frame = 2

Query:   59 DEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQSILELAQTT 307
            + ELG K+DRC++DG IK                     P+ FGS  GLGMA ANC NDL+    L     H+   + LA  T
Sbjct:    3 ERELGRKLDRCLADGVIKL----------------GHAWPISFGSGAGLGMAYANCQNDLRWHYLL-----HRNPKVALADET 64

[Close]

BLAST of MICOS complex subunit MIC10 vs. Planmine SMEST
Match: SMESG000039213.1 (SMESG000039213.1)

HSP 1 Score: 233.032 bits (593), Expect = 9.010e-80
Identity = 141/141 (100.00%), Postives = 141/141 (100.00%), Query Frame = 2

Query:   44 MSAKIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQSILELAQTTGSQITKTSNVTDINTMKGDGASRTXXXXXXXXXXXXXDPASFSVKGCKKRTKN 466
            MSAKIDEELGMKIDRCISDGFIKTIVGAGVGVVASVMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQSILELAQTTGSQITKTSNVTDINTMKGDGASRTEKSNEKSNEKNSEDPASFSVKGCKKRTKN
Sbjct:    1 MSAKIDEELGMKIDRCISDGFIKTIVGAGVGVVASVMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHKQSILELAQTTGSQITKTSNVTDINTMKGDGASRTEKSNEKSNEKNSEDPASFSVKGCKKRTKN 141

[Close]

BLAST of MICOS complex subunit MIC10 vs. Planmine SMEST
Match: SMESG000009106.1 (SMESG000009106.1)

HSP 1 Score: 75.8702 bits (185), Expect = 1.119e-18
Identity = 37/76 (48.68%), Postives = 54/76 (71.05%), Query Frame = 2

Query:   50 AKIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKIHK 277
             K ++ELG+K+DRC SD  +K   G  +G+V S + FKR+PG ++F + +G+GMA+ANCNND K P S+V  +I K
Sbjct:    4 VKTEDELGVKVDRCFSDAVVKIAGGVSIGIVGSFLLFKRKPGIILFSTGIGIGMALANCNNDFKMPCSVVHNQIIK 79

[Close]

BLAST of MICOS complex subunit MIC10 vs. Planmine SMEST
Match: SMESG000009106.1 (SMESG000009106.1)

HSP 1 Score: 75.0998 bits (183), Expect = 1.870e-18
Identity = 36/74 (48.65%), Postives = 53/74 (71.62%), Query Frame = 2

Query:   50 AKIDEELGMKIDRCISDGFIKTIXXXXXXXXXXXMFFKRRPGPLIFGSALGLGMAIANCNNDLKQPLSLVSGKI 271
             K ++ELG+K+DRC SD  +K   G  +G+V S + FKR+PG ++F + +G+GMA+ANCNND K P S+V  +I
Sbjct:    4 VKTEDELGVKVDRCFSDAVVKIAGGVSIGIVGSFLLFKRKPGIILFSTGIGIGMALANCNNDFKMPCSVVHNQI 77

The following BLAST results are available for this feature:

BLAST of MICOS complex subunit MIC10 vs. Ensembl Human
BLAST of MICOS complex subunit MIC10 vs. Ensembl Celegans
BLAST of MICOS complex subunit MIC10 vs. Ensembl Fly
BLAST of MICOS complex subunit MIC10 vs. Ensembl Zebrafish
BLAST of MICOS complex subunit MIC10 vs. Ensembl Xenopus
BLAST of MICOS complex subunit MIC10 vs. Ensembl Mouse
BLAST of MICOS complex subunit MIC10 vs. UniProt/SwissProt
BLAST of MICOS complex subunit MIC10 vs. TrEMBL
BLAST of MICOS complex subunit MIC10 vs. Ensembl Cavefish
BLAST of MICOS complex subunit MIC10 vs. Ensembl Sea Lamprey
BLAST of MICOS complex subunit MIC10 vs. Ensembl Yeast
BLAST of MICOS complex subunit MIC10 vs. Ensembl Nematostella
BLAST of MICOS complex subunit MIC10 vs. Ensembl Medaka
BLAST of MICOS complex subunit MIC10 vs. Planmine SMEST

BLAST of MICOS complex subunit MIC10 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
MICOS10	3.208e-14	50.00	mitochondrial contact site and cristae organizing ...	[more]
MICOS10-NBL1	6.743e-12	49.28	MICOS10-NBL1 readthrough [Source:HGNC Symbol;Acc:H...	[more]
MICOS10	2.711e-9	37.84	mitochondrial contact site and cristae organizing ...	[more]
MICOS10-NBL1	1.738e-8	54.76	MICOS10-NBL1 readthrough [Source:HGNC Symbol;Acc:H...	[more]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
F54A3.5	3.031e-12	46.97	MICOS complex subunit Mic10 [Source:UniProtKB/Swi...	[more]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
CG12479	2.140e-7	35.38	gene:FBgn0040871 transcript:FBtr0073869	[more]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
micos10	5.546e-13	51.52	mitochondrial contact site and cristae organizing ...	[more]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of MICOS complex subunit MIC10 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1


Match Name	E-value	Identity	Description
Micos10	8.714e-14	50.00	mitochondrial contact site and cristae organizing ...	[more]

BLAST of MICOS complex subunit MIC10 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 4


Match Name	E-value	Identity	Description
sp\|Q5TGZ0\|MIC10_HUMAN	1.540e-13	50.00	MICOS complex subunit MIC10 OS=Homo sapiens OX=960...	[more]
sp\|Q7TNS2\|MIC10_MOUSE	6.096e-13	50.00	MICOS complex subunit Mic10 OS=Mus musculus OX=100...	[more]
sp\|B2RYW8\|MIC10_RAT	1.249e-12	48.65	MICOS complex subunit Mic10 OS=Rattus norvegicus O...	[more]
sp\|Q9N4K0\|MIC10_CAEEL	3.856e-11	46.97	MICOS complex subunit Mic10 OS=Caenorhabditis eleg...	[more]

BLAST of MICOS complex subunit MIC10 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
Q5BSC7	1.046e-17	61.64	MICOS complex subunit MIC10 OS=Schistosoma japonic...	[more]
A0A183BGC3	1.313e-17	56.25	MICOS complex subunit MIC10 OS=Echinostoma caproni...	[more]
C1LK15	5.364e-17	62.86	MICOS complex subunit MIC10 OS=Schistosoma japonic...	[more]
A0A146MHV0	8.806e-17	60.27	MICOS complex subunit MIC10 OS=Schistosoma mansoni...	[more]
A0A146MGH5	9.370e-17	60.27	MICOS complex subunit MIC10 OS=Schistosoma mansoni...	[more]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSAMXT00000030462.1	7.413e-16	53.85	pep primary_assembly:Astyanax_mexicanus-2.0:22:180...	[more]
micos10	1.141e-14	50.00	MICOS complex subunit MIC10 [Source:NCBI gene;Acc:...	[more]

BLAST of MICOS complex subunit MIC10 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of MICOS complex subunit MIC10 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of MICOS complex subunit MIC10 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of MICOS complex subunit MIC10 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ENSORLT00000035437.1	6.190e-15	49.40	pep primary_assembly:ASM223467v1:7:1586357:1587485...	[more]
ENSORLT00000027538.1	1.274e-13	47.44	mitochondrial contact site and cristae organizing ...	[more]
ENSORLT00000029141.1	2.630e-9	37.35	pep primary_assembly:ASM223467v1:7:1586357:1587485...	[more]

BLAST of MICOS complex subunit MIC10 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000039213.1	9.010e-80	100.00	SMESG000039213.1	[more]
SMESG000009106.1	1.119e-18	48.68	SMESG000009106.1	[more]
SMESG000009106.1	1.870e-18	48.65	SMESG000009106.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30029473 ID=SMED30029473|Name=MICOS complex subunit MIC10|organism=Schmidtea mediterranea sexual|type=transcript|length=479bp
ATTTTGGATTTTAATTAATTTTAAATTAAGTGAAGGATAATTGATGTCAG
CGAAAATAGACGAAGAACTCGGAATGAAAATCGATCGGTGTATATCAGAT
GGATTTATTAAAACGATTGTCGGAGCTGGAGTTGGAGTCGTAGCGTCAGT
TATGTTTTTTAAAAGAAGACCAGGACCTCTAATTTTTGGATCAGCTTTAG
GATTAGGAATGGCAATTGCAAATTGCAATAATGATCTTAAGCAACCGCTA
TCCCTTGTTTCAGGCAAAATACATAAACAATCTATTTTGGAACTAGCTCA
AACAACTGGAAGCCAAATAACTAAAACATCTAATGTAACTGATATCAATA
CAATGAAGGGTGACGGAGCTAGTCGAACTGAAAAAAGTAATGAAAAAAGT
AATGAAAAAAATAGTGAAGATCCAGCTAGTTTCAGTGTAAAAGGATGTAA
AAAGAGAACAAAAAATTAACGAATTTGGC

protein sequence of SMED30029473-orf-1

>SMED30029473-orf-1 ID=SMED30029473-orf-1|Name=SMED30029473-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=142bp
MSAKIDEELGMKIDRCISDGFIKTIVGAGVGVVASVMFFKRRPGPLIFGS
ALGLGMAIANCNNDLKQPLSLVSGKIHKQSILELAQTTGSQITKTSNVTD
INTMKGDGASRTEKSNEKSNEKNSEDPASFSVKGCKKRTKN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002109	X1 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR007512	Mic10

Vocabulary: **cellular component**
Term	Definition
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0061617	MICOS complex

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR007512	MICOS complex subunit Mic10	PFAM	PF04418	DUF543	coord: 6..64 e-value: 7.3E-14 score: 51.5
IPR007512	MICOS complex subunit Mic10	PANTHER	PTHR21304	UNCHARACTERIZED	coord: 6..78
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 93..141
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 93..109
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 110..124
None	No IPR available	PANTHER	PTHR21304:SF5	MICOS COMPLEX SUBUNIT MIC10	coord: 6..78
None	No IPR available	TMHMM	TMhelix		coord: 20..39

Main menu

MICOS complex subunit MIC10

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Owlery

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