epidermal growth factor receptor 2
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029442 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of epidermal growth factor receptor 2 vs. Ensembl Human
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 249.595 bits (636), Expect = 3.113e-67 Identity = 165/487 (33.88%), Postives = 254/487 (52.16%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCVERC---TVTPNDPFQCGSCNFKRLYLDNHNKSCVSECPQ-------THKYKHKDGNLTDIICMTRSQWLSY--------QENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C C G CV +C + PR N+ C C+ C+ + T T P C C Y+D + CV CP T +K+ D +C + PK S + ++ +++ + +++ F I +K++++ L + E + L PN L ++ T+ K +G+GAFG VY+G+W P + ++ + VA+K +R A +EI++EA VMASV + H RL+GICL + LIT + G L Y+R+HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ + ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ IY+H++DVWS+G+T+WE+ T+G +PYD + EI+S L +G RL QP IC++D+Y +M +CW +A+ RP F L+ S + P YL I D Sbjct: 478 CVSCRNVSRGRECVDKCN-LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH---YIDGPH--CVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRL------LQERELVEPLTPSGEAPNQALLRILKETEFK---KIKVLGSGAFGTVYKGLWIPEGEKVK------IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEE---KEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGD 939 HSP 2 Score: 101.293 bits (251), Expect = 8.956e-21 Identity = 89/313 (28.43%), Postives = 131/313 (41.85%), Query Frame = 3 Query: 1044 DVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLG---NVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNW------TGNILK--NNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRC---EDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ-----NCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGC 1889 D + A +K+F + + G+ H +F T P+ + L V+ ITG L+I +L +NL+ IR Q +L ++ ++ LGLR L+ I G + + LCYA+T+NW +G K +N+ + + C + C +GCWGP C +CR CVD+C E EP +++ +N + C +CHP CL CTG P NCI C ++ + CVK C KY C CH C CTG GL GC Sbjct: 302 DSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEP---------REFVENSE---CIQCHPECLPQAMNITCTGRGPDNCI-QCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYG------CTGP----GLEGC 591 HSP 3 Score: 85.8853 bits (211), Expect = 4.591e-16 Identity = 77/251 (30.68%), Postives = 107/251 (42.63%), Query Frame = 2 Query: 158 HNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 +NC V GNL I V Q + DL FL +I EV G + + N+++ I L NL++IRG + ENS YA L V++N Y K K LP N + QK C C CW + +CQK +K + + C + R G+ C QC GC GP+ SDC VC+K+ + C + CPP +Y+ ++ NP K G C CP Sbjct: 56 NNCEVVLGNLEITYV---QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGN----------------MYYENS-YA----LAVLSN---YDANKTGLKELP--------MRNLQGQK-----------CDPSCPNGS---CWGAGEENCQKLTKII-----CAQQCSGRCR-GKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCP 251
BLAST of epidermal growth factor receptor 2 vs. Ensembl Human
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 250.366 bits (638), Expect = 3.314e-67 Identity = 165/487 (33.88%), Postives = 254/487 (52.16%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCVERC---TVTPNDPFQCGSCNFKRLYLDNHNKSCVSECP-------QTHKYKHKDGNLTDIICMTRSQWLSY--------QENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C C G CV +C + PR N+ C C+ C+ + T T P C C Y+D + CV CP T +K+ D +C + PK S + ++ +++ + +++ F I +K++++ L + E + L PN L ++ T+ K +G+GAFG VY+G+W P + ++ + VA+K +R A +EI++EA VMASV + H RL+GICL + LIT + G L Y+R+HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ + ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ IY+H++DVWS+G+T+WE+ T+G +PYD + EI+S L +G RL QP IC++D+Y +M +CW +A+ RP F L+ S + P YL I D Sbjct: 478 CVSCRNVSRGRECVDKCN-LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH---YIDGPH--CVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRL------LQERELVEPLTPSGEAPNQALLRILKETEFK---KIKVLGSGAFGTVYKGLWIPEGEKVK------IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEE---KEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGD 939 HSP 2 Score: 101.293 bits (251), Expect = 9.258e-21 Identity = 89/313 (28.43%), Postives = 131/313 (41.85%), Query Frame = 3 Query: 1044 DVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLG---NVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNW------TGNILK--NNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRC---EDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ-----NCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGC 1889 D + A +K+F + + G+ H +F T P+ + L V+ ITG L+I +L +NL+ IR Q +L ++ ++ LGLR L+ I G + + LCYA+T+NW +G K +N+ + + C + C +GCWGP C +CR CVD+C E EP +++ +N + C +CHP CL CTG P NCI C ++ + CVK C KY C CH C CTG GL GC Sbjct: 302 DSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEP---------REFVENSE---CIQCHPECLPQAMNITCTGRGPDNCI-QCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYG------CTGP----GLEGC 591 HSP 3 Score: 85.8853 bits (211), Expect = 4.579e-16 Identity = 77/251 (30.68%), Postives = 107/251 (42.63%), Query Frame = 2 Query: 158 HNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 +NC V GNL I V Q + DL FL +I EV G + + N+++ I L NL++IRG + ENS YA L V++N Y K K LP N + QK C C CW + +CQK +K + + C + R G+ C QC GC GP+ SDC VC+K+ + C + CPP +Y+ ++ NP K G C CP Sbjct: 56 NNCEVVLGNLEITYV---QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGN----------------MYYENS-YA----LAVLSN---YDANKTGLKELP--------MRNLQGQK-----------CDPSCPNGS---CWGAGEENCQKLTKII-----CAQQCSGRCR-GKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCP 251
BLAST of epidermal growth factor receptor 2 vs. Ensembl Human
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 249.98 bits (637), Expect = 4.696e-67 Identity = 165/487 (33.88%), Postives = 254/487 (52.16%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCVERC---TVTPNDPFQCGSCNFKRLYLDNHNKSCVSECP-------QTHKYKHKDGNLTDIICMTRSQWLSY--------QENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C C G CV +C + PR N+ C C+ C+ + T T P C C Y+D + CV CP T +K+ D +C + PK S + ++ +++ + +++ F I +K++++ L + E + L PN L ++ T+ K +G+GAFG VY+G+W P + ++ + VA+K +R A +EI++EA VMASV + H RL+GICL + LIT + G L Y+R+HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ + ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ IY+H++DVWS+G+T+WE+ T+G +PYD + EI+S L +G RL QP IC++D+Y +M +CW +A+ RP F L+ S + P YL I D Sbjct: 523 CVSCRNVSRGRECVDKCN-LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH---YIDGPH--CVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVVALGIGLFMRRRHIVRKRTLRRL------LQERELVEPLTPSGEAPNQALLRILKETEFK---KIKVLGSGAFGTVYKGLWIPEGEKVK------IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEE---KEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGD 984 HSP 2 Score: 101.293 bits (251), Expect = 8.996e-21 Identity = 89/313 (28.43%), Postives = 131/313 (41.85%), Query Frame = 3 Query: 1044 DVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLG---NVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNW------TGNILK--NNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRC---EDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ-----NCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGC 1889 D + A +K+F + + G+ H +F T P+ + L V+ ITG L+I +L +NL+ IR Q +L ++ ++ LGLR L+ I G + + LCYA+T+NW +G K +N+ + + C + C +GCWGP C +CR CVD+C E EP +++ +N + C +CHP CL CTG P NCI C ++ + CVK C KY C CH C CTG GL GC Sbjct: 347 DSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCNLLEGEP---------REFVENSE---CIQCHPECLPQAMNITCTGRGPDNCI-QCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYG------CTGP----GLEGC 636 HSP 3 Score: 93.5893 bits (231), Expect = 1.790e-18 Identity = 76/258 (29.46%), Postives = 117/258 (45.35%), Query Frame = 2 Query: 158 HNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFP--KLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCH-SDCLRNDFP----YCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 +NC V GNL I V Q + DL FL +I EV G + + N+++ I L NL++IRG ++ E S + D + P L+ I + +V F + +SI+W ++ + N M+ Q H C + D CW + +CQK +K + + C + R G+ C QC GC GP+ SDC VC+K+ + C + CPP +Y+ ++ NP K G C CP Sbjct: 56 NNCEVVLGNLEITYV---QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRG--NMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNV-ESIQWRDIVSSD-----FLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKII-----CAQQCSGRCR-GKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCP 296 HSP 4 Score: 60.8474 bits (146), Expect = 1.825e-8 Identity = 67/279 (24.01%), Postives = 107/279 (38.35%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIG--EFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIM------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNW----TGNILKNNQFD--PIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNC----------------SRKYFSFNKTCIK 1808 ++ + F + E V+G E + +++D + L +Q + G ++I + + L+NL+ IR + S AL ++ T L+ L +R L+ I G ++P LC +++ W + + L N D C K CD C + CWG G C C RC K +D C CH C CTGPR ++C+ CR F++ C C +SF TC+K Sbjct: 50 SLQRMFNNCEVVLGNLEITYVQRNYDLSF-----------LKTIQEVAGYVLIALNTV---ERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQK-CDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRG-----------KSPSD------C--CHNQCAAGCTGPRESDCL-VCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
BLAST of epidermal growth factor receptor 2 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 249.21 bits (635), Expect = 1.135e-66 Identity = 137/376 (36.44%), Postives = 219/376 (58.24%), Query Frame = 3 Query: 2373 WLSYQENPKFISKWSLIILSVIT-VFLISSVYIFFR-YVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 W + P+ ++ LI VI +F++ V + F YV + + KK + + + + EP L T PN +L ++ T+L K +G+GAFG VY+G+W P + ++ + VA+K++ E M+EA +MAS+ H H +RL+G+CL + L+T + G L +Y+ +HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ ++ITDFGLA ++ E ++ E GG++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + S + P YL I D ++ Sbjct: 612 WTGHSTLPQH-ARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEP-----LTPSGTAPNQAQLRILKETELK---RVKVLGSGAFGTVYKGIWVPEGETVK------IPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL---EGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK 968 HSP 2 Score: 108.997 bits (271), Expect = 3.621e-23 Identity = 79/258 (30.62%), Postives = 120/258 (46.51%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEEN--SQYAIFPKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENPKKQKLITYNKYMEH---QCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNF--KLRVGYMCANSCP 904 NC V GNL I ++ + + DL FL S+ EVTG + + N + + L NL++IRG L ++ ++++++ + N Q L I N VY ++KFL +I W+++ NP L + +CH C CW + NHCQ ++ V E+ D CY G C +C GGC+GPK++DC C + + CV CP F+Y+ +L NF K G C CP Sbjct: 29 NCEVVMGNLEITSI---EHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRG-TKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVD---QNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGR----CWGPTENHCQTLTRTVCAEQCDG--RCY-----GPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCP 268 HSP 3 Score: 80.4925 bits (197), Expect = 1.842e-14 Identity = 67/252 (26.59%), Postives = 100/252 (39.68%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTG--------NILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLC------LQNCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTGESS 1868 V+ ITG L I + + + NL I + S + L + + L + L+ I G + D+ LCY T+NWT ++++N+ C+ C S GCWGPG C +CR F C++ C G ++ + + IC C P C L C GP P NC C +FK+ CV+ C KY ++ C CH C + C G +S Sbjct: 369 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDG---------EFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQG------CNGPTS 604 HSP 4 Score: 59.3066 bits (142), Expect = 5.221e-8 Identity = 95/411 (23.11%), Postives = 151/411 (36.74%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFL--QNLKEIRHLLTQSASAALNIM-------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQG-----------CWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPF 2234 A+ K + + E V+G T+ ++ L L +V+ +TG +++ L +L +NL+ IR AL I + L+ LGL+ L I G V + LCYADT++W +I++N P N S S G CWGP + C C RC Y + CH C C+GP+ T+C C F ++ CV C + F +N T + +E++ N G ++C K K F C R +K+++ E I +C+PC + C + C+G +G Q + N+ + +C NGN + T DP+ Sbjct: 22 ALRKYYENCEVVMGNLEITSIEHNRDL---------SFLRSVREVTGYVLV-----ALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQ-DIVRNPW------PSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRC-------------------YGPYVSDCCHRECAGGCSGPKDTDCF-ACMNFNDSGACVTQCPQT-FVYNPTTFQ-----LEHNFNAKYTYG----------AFCVK---KCPHNFVVDSSSCVRACPSSKMEVEE-------NGIKMCKPCTDICPKA------------CDGIGTGSLMSAQTVDSS-NIDKFINCTKINGNLIFLVTGIHGDPY 352 HSP 5 Score: 56.225 bits (134), Expect = 4.703e-7 Identity = 33/84 (39.29%), Postives = 39/84 (46.43%), Query Frame = 3 Query: 1485 CDSKCDSQ-----GCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCI 1721 CD +C+ C GPG C C F+ NCV++C D G S I KY D D C CHP C Q C GP +CI Sbjct: 529 CDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPD--GLQGANSFIFKYAD--PDRECHPCHPNCTQGCNGPTSHDCI 608
BLAST of epidermal growth factor receptor 2 vs. Ensembl Human
Match: ERBB4 (erb-b2 receptor tyrosine kinase 4 [Source:HGNC Symbol;Acc:HGNC:3432]) HSP 1 Score: 249.21 bits (635), Expect = 1.342e-66 Identity = 137/376 (36.44%), Postives = 219/376 (58.24%), Query Frame = 3 Query: 2373 WLSYQENPKFISKWSLIILSVIT-VFLISSVYIFFR-YVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 W + P+ ++ LI VI +F++ V + F YV + + KK + + + + EP L T PN +L ++ T+L K +G+GAFG VY+G+W P + ++ + VA+K++ E M+EA +MAS+ H H +RL+G+CL + L+T + G L +Y+ +HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ ++ITDFGLA ++ E ++ E GG++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + S + P YL I D ++ Sbjct: 638 WTGHSTLPQH-ARTPLIAAGVIGGLFILVIVGLTFAVYVRRKSIKKKRALRRFLETELVEP-----LTPSGTAPNQAQLRILKETELK---RVKVLGSGAFGTVYKGIWVPEGETVK------IPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL---EGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK 994 HSP 2 Score: 108.997 bits (271), Expect = 3.722e-23 Identity = 79/258 (30.62%), Postives = 120/258 (46.51%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEEN--SQYAIFPKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENPKKQKLITYNKYMEH---QCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNF--KLRVGYMCANSCP 904 NC V GNL I ++ + + DL FL S+ EVTG + + N + + L NL++IRG L ++ ++++++ + N Q L I N VY ++KFL +I W+++ NP L + +CH C CW + NHCQ ++ V E+ D CY G C +C GGC+GPK++DC C + + CV CP F+Y+ +L NF K G C CP Sbjct: 55 NCEVVMGNLEITSI---EHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRG-TKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVD---QNKFLCYADTIHWQDIVRNPWPSNLTLVSTNGSSGCGRCHKSCTGR----CWGPTENHCQTLTRTVCAEQCDG--RCY-----GPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCP 294 HSP 3 Score: 80.8777 bits (198), Expect = 1.712e-14 Identity = 67/252 (26.59%), Postives = 100/252 (39.68%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTG--------NILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLC------LQNCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTGESS 1868 V+ ITG L I + + + NL I + S + L + + L + L+ I G + D+ LCY T+NWT ++++N+ C+ C S GCWGPG C +CR F C++ C G ++ + + IC C P C L C GP P NC C +FK+ CV+ C KY ++ C CH C + C G +S Sbjct: 395 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDG---------EFREFENGSICVECDPQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADPDRECHPCHPNCTQG------CNGPTS 630 HSP 4 Score: 59.6918 bits (143), Expect = 4.999e-8 Identity = 95/411 (23.11%), Postives = 151/411 (36.74%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFL--QNLKEIRHLLTQSASAALNIM-------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQG-----------CWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPF 2234 A+ K + + E V+G T+ ++ L L +V+ +TG +++ L +L +NL+ IR AL I + L+ LGL+ L I G V + LCYADT++W +I++N P N S S G CWGP + C C RC Y + CH C C+GP+ T+C C F ++ CV C + F +N T + +E++ N G ++C K K F C R +K+++ E I +C+PC + C + C+G +G Q + N+ + +C NGN + T DP+ Sbjct: 48 ALRKYYENCEVVMGNLEITSIEHNRDL---------SFLRSVREVTGYVLV-----ALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQ-DIVRNPW------PSNLTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRC-------------------YGPYVSDCCHRECAGGCSGPKDTDCF-ACMNFNDSGACVTQCPQT-FVYNPTTFQ-----LEHNFNAKYTYG----------AFCVK---KCPHNFVVDSSSCVRACPSSKMEVEE-------NGIKMCKPCTDICPKA------------CDGIGTGSLMSAQTVDSS-NIDKFINCTKINGNLIFLVTGIHGDPY 378 HSP 5 Score: 56.225 bits (134), Expect = 4.463e-7 Identity = 33/84 (39.29%), Postives = 39/84 (46.43%), Query Frame = 3 Query: 1485 CDSKCDSQ-----GCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCI 1721 CD +C+ C GPG C C F+ NCV++C D G S I KY D D C CHP C Q C GP +CI Sbjct: 555 CDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPD--GLQGANSFIFKYAD--PDRECHPCHPNCTQGCNGPTSHDCI 634
BLAST of epidermal growth factor receptor 2 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 332.413 bits (851), Expect = 2.235e-111 Identity = 276/985 (28.02%), Postives = 439/985 (44.57%), Query Frame = 3 Query: 906 EVDACIYSCNSLHFYRVDN---KCIRCQNSS---VCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIE----HVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH-TDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNI------------LKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRY-------FKENDECVKNCSRKYFSFNK-TCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRH---------YYLNKIDISEVMKRQKSKEIGICQPCLEPCLECS--GNYTIYPTCEKCNGYW----SGDRCVKQCFPIALNLP--RNASCPYCNGNCVERCTVTPNDPFQCGSC-NFKRLYLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND------SCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFV---GDYQDDIEGEPSLKRQSSGFSWSS 3683 E D C+ C+ H Y +C +C++SS +C ++T LKN E H+I E FT + K L V+ ++ + I N +L FL+NL+ I + AL I DLE L L L+ I G + + LCY ++W+ I + N+ + + CD C+ +GCWG C C+ +++V CV++C D GF N +++K C+RC P C + C G +C+ CR+ F ECV +C +F K C KCH TC +N CTG S LG GGC C + ++ +C + + YY++ D V++ C+ C C CS G + C + + S C+ QC + +P N C C+ C + C C NF D CVSECP+ + + + L Y + +II SV+ F + ++I Y K +K I + P+ I + PNM+R+ LIP+++L ++ K +G GAFG V+ G++ P +++ + VA+KV + +++ E++EEA M + H + L++IG C+ + ++T + LG+L +L+ HK L +R + + QIA GM YLE + ++HRDLATRNVL+ ++ITDFGL+ I++ D+ I I G+V I+WLA+E Y+H +DVW+FG+T WEI T+G+ PY + I ++L GNRL+QP CS DLYQ + RCW + RP FE L F + P +L N S + ++ R + + D Q+Y ++ S +++TF GD + ++ S + ++ F + S Sbjct: 272 ENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG---------------HLTNETLKNLEGCEQIDGHLIIEHAFTYEQL-------------KVLETVKIVSEYITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQTSMK----------CERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNG-----CTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETH-------CEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDI--AQCVSECPKNLPFSNP----------ANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLK----IAEMVDMPELTPI--DASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYP-----KRAKNVKIPVAIKVFQTDQS-QTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADS---ITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGS 1173 HSP 2 Score: 91.6633 bits (226), Expect = 2.235e-111 Identity = 77/271 (28.41%), Postives = 116/271 (42.80%), Query Frame = 2 Query: 152 GNHNCTHVEGNLVIQ-------NVWPDQESGDL---GFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYME--------HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 GN T +E N + + V P E L F ++ E+ G + + +I+ I P L+VI G + ++YI D+ + + +LRVI N SV + K ++ I W+EL +P QK+ T N + +CH C ND CW S N CQ+ + V K + C++ N CD C GGC G +C C KY C+E CP I++ +L NP+ + + G C CP Sbjct: 10 GNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF----HDNALYIHKNDKVHE--VVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC--ND--KCWGSGDNDCQRVYRSVCPK--SCSQCFYS--NSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECP 266
BLAST of epidermal growth factor receptor 2 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 332.028 bits (850), Expect = 2.728e-111 Identity = 276/985 (28.02%), Postives = 439/985 (44.57%), Query Frame = 3 Query: 906 EVDACIYSCNSLHFYRVDN---KCIRCQNSS---VCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIE----HVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH-TDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNI------------LKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRY-------FKENDECVKNCSRKYFSFNK-TCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRH---------YYLNKIDISEVMKRQKSKEIGICQPCLEPCLECS--GNYTIYPTCEKCNGYW----SGDRCVKQCFPIALNLP--RNASCPYCNGNCVERCTVTPNDPFQCGSC-NFKRLYLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND------SCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFV---GDYQDDIEGEPSLKRQSSGFSWSS 3683 E D C+ C+ H Y +C +C++SS +C ++T LKN E H+I E FT + K L V+ ++ + I N +L FL+NL+ I + AL I DLE L L L+ I G + + LCY ++W+ I + N+ + + CD C+ +GCWG C C+ +++V CV++C D GF N +++K C+RC P C + C G +C+ CR+ F ECV +C +F K C KCH TC +N CTG S LG GGC C + ++ +C + + YY++ D V++ C+ C C CS G + C + + S C+ QC + +P N C C+ C + C C NF D CVSECP+ + + + L Y + +II SV+ F + ++I Y K +K I + P+ I + PNM+R+ LIP+++L ++ K +G GAFG V+ G++ P +++ + VA+KV + +++ E++EEA M + H + L++IG C+ + ++T + LG+L +L+ HK L +R + + QIA GM YLE + ++HRDLATRNVL+ ++ITDFGL+ I++ D+ I I G+V I+WLA+E Y+H +DVW+FG+T WEI T+G+ PY + I ++L GNRL+QP CS DLYQ + RCW + RP FE L F + P +L N S + ++ R + + D Q+Y ++ S +++TF GD + ++ S + ++ F + S Sbjct: 333 ENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG---------------HLTNETLKNLEGCEQIDGHLIIEHAFTYEQL-------------KVLETVKIVSEYITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQTSMK----------CERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNG-----CTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETH-------CEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDI--AQCVSECPKNLPFSNP----------ANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLK----IAEMVDMPELTPI--DASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYP-----KRAKNVKIPVAIKVFQTDQS-QTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADS---ITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGS 1234 HSP 2 Score: 92.0485 bits (227), Expect = 2.728e-111 Identity = 77/271 (28.41%), Postives = 116/271 (42.80%), Query Frame = 2 Query: 152 GNHNCTHVEGNLVIQ-------NVWPDQESGDL---GFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYME--------HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 GN T +E N + + V P E L F ++ E+ G + + +I+ I P L+VI G + ++YI D+ + + +LRVI N SV + K ++ I W+EL +P QK+ T N + +CH C ND CW S N CQ+ + V K + C++ N CD C GGC G +C C KY C+E CP I++ +L NP+ + + G C CP Sbjct: 71 GNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF----HDNALYIHKNDKVHE--VVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC--ND--KCWGSGDNDCQRVYRSVCPK--SCSQCFYS--NSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECP 327
BLAST of epidermal growth factor receptor 2 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 331.643 bits (849), Expect = 2.891e-111 Identity = 276/985 (28.02%), Postives = 439/985 (44.57%), Query Frame = 3 Query: 906 EVDACIYSCNSLHFYRVDN---KCIRCQNSS---VCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIE----HVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH-TDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNI------------LKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRY-------FKENDECVKNCSRKYFSFNK-TCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRH---------YYLNKIDISEVMKRQKSKEIGICQPCLEPCLECS--GNYTIYPTCEKCNGYW----SGDRCVKQCFPIALNLP--RNASCPYCNGNCVERCTVTPNDPFQCGSC-NFKRLYLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND------SCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFV---GDYQDDIEGEPSLKRQSSGFSWSS 3683 E D C+ C+ H Y +C +C++SS +C ++T LKN E H+I E FT + K L V+ ++ + I N +L FL+NL+ I + AL I DLE L L L+ I G + + LCY ++W+ I + N+ + + CD C+ +GCWG C C+ +++V CV++C D GF N +++K C+RC P C + C G +C+ CR+ F ECV +C +F K C KCH TC +N CTG S LG GGC C + ++ +C + + YY++ D V++ C+ C C CS G + C + + S C+ QC + +P N C C+ C + C C NF D CVSECP+ + + + L Y + +II SV+ F + ++I Y K +K I + P+ I + PNM+R+ LIP+++L ++ K +G GAFG V+ G++ P +++ + VA+KV + +++ E++EEA M + H + L++IG C+ + ++T + LG+L +L+ HK L +R + + QIA GM YLE + ++HRDLATRNVL+ ++ITDFGL+ I++ D+ I I G+V I+WLA+E Y+H +DVW+FG+T WEI T+G+ PY + I ++L GNRL+QP CS DLYQ + RCW + RP FE L F + P +L N S + ++ R + + D Q+Y ++ S +++TF GD + ++ S + ++ F + S Sbjct: 338 ENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG---------------HLTNETLKNLEGCEQIDGHLIIEHAFTYEQL-------------KVLETVKIVSEYITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQTSMK----------CERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNG-----CTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETH-------CEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDI--AQCVSECPKNLPFSNP----------ANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLK----IAEMVDMPELTPI--DASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYP-----KRAKNVKIPVAIKVFQTDQS-QTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADS---ITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGS 1239 HSP 2 Score: 92.0485 bits (227), Expect = 2.891e-111 Identity = 77/271 (28.41%), Postives = 116/271 (42.80%), Query Frame = 2 Query: 152 GNHNCTHVEGNLVIQ-------NVWPDQESGDL---GFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYME--------HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 GN T +E N + + V P E L F ++ E+ G + + +I+ I P L+VI G + ++YI D+ + + +LRVI N SV + K ++ I W+EL +P QK+ T N + +CH C ND CW S N CQ+ + V K + C++ N CD C GGC G +C C KY C+E CP I++ +L NP+ + + G C CP Sbjct: 76 GNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF----HDNALYIHKNDKVHE--VVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC--ND--KCWGSGDNDCQRVYRSVCPK--SCSQCFYS--NSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECP 332
BLAST of epidermal growth factor receptor 2 vs. Ensembl Celegans
Match: let-23 (Receptor tyrosine-protein kinase let-23 [Source:UniProtKB/Swiss-Prot;Acc:P24348]) HSP 1 Score: 331.643 bits (849), Expect = 2.915e-111 Identity = 276/985 (28.02%), Postives = 439/985 (44.57%), Query Frame = 3 Query: 906 EVDACIYSCNSLHFYRVDN---KCIRCQNSS---VCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIE----HVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH-TDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNI------------LKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRY-------FKENDECVKNCSRKYFSFNK-TCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRH---------YYLNKIDISEVMKRQKSKEIGICQPCLEPCLECS--GNYTIYPTCEKCNGYW----SGDRCVKQCFPIALNLP--RNASCPYCNGNCVERCTVTPNDPFQCGSC-NFKRLYLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND------SCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFV---GDYQDDIEGEPSLKRQSSGFSWSS 3683 E D C+ C+ H Y +C +C++SS +C ++T LKN E H+I E FT + K L V+ ++ + I N +L FL+NL+ I + AL I DLE L L L+ I G + + LCY ++W+ I + N+ + + CD C+ +GCWG C C+ +++V CV++C D GF N +++K C+RC P C + C G +C+ CR+ F ECV +C +F K C KCH TC +N CTG S LG GGC C + ++ +C + + YY++ D V++ C+ C C CS G + C + + S C+ QC + +P N C C+ C + C C NF D CVSECP+ + + + L Y + +II SV+ F + ++I Y K +K I + P+ I + PNM+R+ LIP+++L ++ K +G GAFG V+ G++ P +++ + VA+KV + +++ E++EEA M + H + L++IG C+ + ++T + LG+L +L+ HK L +R + + QIA GM YLE + ++HRDLATRNVL+ ++ITDFGL+ I++ D+ I I G+V I+WLA+E Y+H +DVW+FG+T WEI T+G+ PY + I ++L GNRL+QP CS DLYQ + RCW + RP FE L F + P +L N S + ++ R + + D Q+Y ++ S +++TF GD + ++ S + ++ F + S Sbjct: 345 ENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG---------------HLTNETLKNLEGCEQIDGHLIIEHAFTYEQL-------------KVLETVKIVSEYITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQTSMK----------CERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNG-----CTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETH-------CEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDI--AQCVSECPKNLPFSNP----------ANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLK----IAEMVDMPELTPI--DASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYP-----KRAKNVKIPVAIKVFQTDQS-QTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADS---ITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGS 1246 HSP 2 Score: 92.0485 bits (227), Expect = 2.915e-111 Identity = 77/271 (28.41%), Postives = 116/271 (42.80%), Query Frame = 2 Query: 152 GNHNCTHVEGNLVIQ-------NVWPDQESGDL---GFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYME--------HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 GN T +E N + + V P E L F ++ E+ G + + +I+ I P L+VI G + ++YI D+ + + +LRVI N SV + K ++ I W+EL +P QK+ T N + +CH C ND CW S N CQ+ + V K + C++ N CD C GGC G +C C KY C+E CP I++ +L NP+ + + G C CP Sbjct: 83 GNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF----HDNALYIHKNDKVHE--VVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC--ND--KCWGSGDNDCQRVYRSVCPK--SCSQCFYS--NSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECP 339
BLAST of epidermal growth factor receptor 2 vs. Ensembl Celegans
Match: R151.1 (pep chromosome:WBcel235:III:7218813:7221186:1 gene:WBGene00020106.1 transcript:R151.1c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:R151.1) HSP 1 Score: 187.578 bits (475), Expect = 8.022e-51 Identity = 104/268 (38.81%), Postives = 160/268 (59.70%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANR-NIDIQEIMEEAKVMASVC-HKHCLRLIGICLKYEMPCLITTFVELGSLDKYL---RKHK---STLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTL 3431 IG GAFG V++G+ + N + + VAVK ++AN + + +E + E ++M +V H + + + G C+ ++ C+I +V G L YL RK K S + S+ LS+ QIA GM +LE GIIHRDLA RN+L+ ++++I+DFG++ I +S G +P+RWL+ E + + YS+K+DVW+FG+ LWEI T G PY+ + ++I + L +G RL QP CS D+Y LM CW A DRPSF ++S + Sbjct: 195 IGEGAFGQVFKGILRGPNGQV-------IPVAVKQLKANAIDEEREEFVREIQMMQTVGQHDNIVTMYGYCMDEQLQCMIMEYVPYGDLKHYLQNMRKEKDSDSAIDSKEFLSFTNQIACGMAHLESVGIIHRDLAARNILVGTGKVLKISDFGMSR-------PGVYIKMSKGVIPLRWLSPEAIKDNTYSNKSDVWAFGVLLWEIATLGGFPYNNVADKDILNQLTEGMRLEQPAKCSDDMYILMKSCWNLKAEDRPSFLAILSKI 448
BLAST of epidermal growth factor receptor 2 vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071653) HSP 1 Score: 341.273 bits (874), Expect = 6.500e-97 Identity = 247/858 (28.79%), Postives = 410/858 (47.79%), Query Frame = 3 Query: 1047 VFYMTAAILKNFTDIEHVIGEFHFTAQSFDK--------ALGGITLPMLYKHL---GNVQYITGDLIIDGSNIVLKNLTFLQNLKEIR-HLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTG-------NILKNNQFDPIYPPCNKP---CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRD---EKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYP-TCEKCNGYWSGDRCVKQCFPIALNLPRNASC----PYCNGNCVERCTVTPNDPFQCGSC-NFKRL-------YLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVIT-VFLISSVYIF--FRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVK-VIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 V + A + +F + + G Q+F +G +P+ + L V+ ITG L I+G++ +NL++ +NL+ I L +S AAL I+ + L L +R L++I G + + LCY + W + N C K C +C+ GCWG G+ C C+ F C+ C G+ +N +D+ C+ CHP C + C G +C C + ++ CV C + ++ C +CH TC CTG +G+G C+ C+ I D ++ D CP Y+ + E + +C+ C C C+ NY + C KC Y ++C +C C P CNG CT D C SC NFK Y+++ +C S+CP ++ + C S + K + + ++ +IT L+ ++ I Y+ + QK + +K + DS L+ N+ +L ++ +L +G GAFG VY+GVW P ++++ + VA+K ++++ +E + EA +MASV H + L+L+ +C+ +M LIT + LG L Y+R ++ + S+ LL+W QIA GM+YLE + ++HRDLA RNVL+ +++ITDFGLA ++ + NE +GG++PI+WLALE + N +++ K+DVW+FG+T+WE+ T+G+RP++ + ++I + G +L QPEICS+D+Y + CW+ +A RP+F+ L + + F + P YL IP D R Sbjct: 357 VTVLHAGNIDSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADL--CEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAY-------KFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDG-------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCT-NYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNG-----CTGPGAD--DCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAA-----SPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEP-LRPSNIGANLCKLRIVKDAELR---KGGVLGMGAFGRVYKGVWVPEGENVK------IPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLS---SDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTR 1165 HSP 2 Score: 108.612 bits (270), Expect = 2.826e-23 Identity = 79/257 (30.74%), Postives = 114/257 (44.36%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQN--SLALEKSEVSVYIDLLDEENSQYAI-FPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL---ITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCPG 907 NCT+V+GNL + W E+ DL FL +I EVTG I + + +K ++ P L++IRG+ SL++E+ + ++++ + Y + P LR + N V F + ++I+W E+ N T + +CH C CW +CQK SK CY G C C GGC GP DC CK + + C E CPP Y+ L NP K G C CPG Sbjct: 79 NCTYVDGNLEL--TWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTY----SKMYTLEIPDLRDVLNGQVGFHNNYNLCHM-RTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHG----CWGEGPKNCQKFSKLTCSPQCAGGRCY-----GPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPG 319
BLAST of epidermal growth factor receptor 2 vs. Ensembl Fly
Match: Egfr (gene:FBgn0003731 transcript:FBtr0071654) HSP 1 Score: 340.887 bits (873), Expect = 1.191e-96 Identity = 246/849 (28.98%), Postives = 404/849 (47.59%), Query Frame = 3 Query: 1044 DVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITL-PMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIR-HLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTG-------NILKNNQFDPIYPPCNKP---CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRD---EKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYP-TCEKCNGYWSGDRCVKQCFPIALNLPRNASC----PYCNGNCVERCTVTPNDPFQCGSC-NFKRL-------YLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVIT-VFLISSVYIF--FRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVK-VIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 D F I N ++ F ++ I L P + V+ ITG L I+G++ +NL++ +NL+ I L +S AAL I+ + L L +R L++I G + + LCY + W + N C K C +C+ GCWG G+ C C+ F C+ C G+ +N +D+ C+ CHP C + C G +C C + ++ CV C + ++ C +CH TC CTG +G+G C+ C+ I D ++ D CP Y+ + E + +C+ C C C+ NY + C KC Y ++C +C C P CNG CT D C SC NFK Y+++ +C S+CP ++ + C S + K + + ++ +IT L+ ++ I Y+ + QK + +K + DS L+ N+ +L ++ +L +G GAFG VY+GVW P ++++ + VA+K ++++ +E + EA +MASV H + L+L+ +C+ +M LIT + LG L Y+R ++ + S+ LL+W QIA GM+YLE + ++HRDLA RNVL+ +++ITDFGLA ++ + NE +GG++PI+WLALE + N +++ K+DVW+FG+T+WE+ T+G+RP++ + ++I + G +L QPEICS+D+Y + CW+ +A RP+F+ L + + F + P YL IP D R Sbjct: 415 DSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERLEVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADL--CEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAY-------KFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDG-------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCT-NYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQCHPECNG-----CTGPGAD--DCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAA-----SPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEP-LRPSNIGANLCKLRIVKDAELR---KGGVLGMGAFGRVYKGVWVPEGENVK------IPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLS---SDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTR 1214 HSP 2 Score: 108.612 bits (270), Expect = 2.534e-23 Identity = 79/257 (30.74%), Postives = 114/257 (44.36%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQN--SLALEKSEVSVYIDLLDEENSQYAI-FPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL---ITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCPG 907 NCT+V+GNL + W E+ DL FL +I EVTG I + + +K ++ P L++IRG+ SL++E+ + ++++ + Y + P LR + N V F + ++I+W E+ N T + +CH C CW +CQK SK CY G C C GGC GP DC CK + + C E CPP Y+ L NP K G C CPG Sbjct: 128 NCTYVDGNLEL--TWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTY----SKMYTLEIPDLRDVLNGQVGFHNNYNLCHM-RTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHG----CWGEGPKNCQKFSKLTCSPQCAGGRCY-----GPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEGVCKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPG 368
BLAST of epidermal growth factor receptor 2 vs. Ensembl Fly
Match: Abl (gene:FBgn0000017 transcript:FBtr0330130) HSP 1 Score: 189.889 bits (481), Expect = 3.399e-48 Identity = 98/266 (36.84%), Postives = 154/266 (57.89%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKH-KSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQ 3446 +G G +G VY VWK R VAVK ++ + + +++ +EEA +M + H + ++LIG+C + +IT F+ G+L +LR + TL + LL QIA GM+YLE R IHRDLA RN L+ D +++++ DFGLA +++ + +G + PI+W A E L +S K+DVW+FG+ LWEI TYG PY +D+ ++ L +G R+ +P C ++Y LM +CW +A DRP+F+++ L Q Sbjct: 377 LGGGQYGEVYEAVWK----------RYGNTVAVKTLKED-TMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMR----DDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQ 627
BLAST of epidermal growth factor receptor 2 vs. Ensembl Fly
Match: Abl (gene:FBgn0000017 transcript:FBtr0330135) HSP 1 Score: 189.504 bits (480), Expect = 3.631e-48 Identity = 98/266 (36.84%), Postives = 154/266 (57.89%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKH-KSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQ 3446 +G G +G VY VWK R VAVK ++ + + +++ +EEA +M + H + ++LIG+C + +IT F+ G+L +LR + TL + LL QIA GM+YLE R IHRDLA RN L+ D +++++ DFGLA +++ + +G + PI+W A E L +S K+DVW+FG+ LWEI TYG PY +D+ ++ L +G R+ +P C ++Y LM +CW +A DRP+F+++ L Q Sbjct: 377 LGGGQYGEVYEAVWK----------RYGNTVAVKTLKED-TMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMR----DDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQ 627
BLAST of epidermal growth factor receptor 2 vs. Ensembl Fly
Match: Abl (gene:FBgn0000017 transcript:FBtr0330131) HSP 1 Score: 189.889 bits (481), Expect = 3.634e-48 Identity = 98/266 (36.84%), Postives = 154/266 (57.89%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKH-KSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQ 3446 +G G +G VY VWK R VAVK ++ + + +++ +EEA +M + H + ++LIG+C + +IT F+ G+L +LR + TL + LL QIA GM+YLE R IHRDLA RN L+ D +++++ DFGLA +++ + +G + PI+W A E L +S K+DVW+FG+ LWEI TYG PY +D+ ++ L +G R+ +P C ++Y LM +CW +A DRP+F+++ L Q Sbjct: 395 LGGGQYGEVYEAVWK----------RYGNTVAVKTLKED-TMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMR----DDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQ 645
BLAST of epidermal growth factor receptor 2 vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64]) HSP 1 Score: 242.662 bits (618), Expect = 3.638e-67 Identity = 123/310 (39.68%), Postives = 189/310 (60.97%), Query Frame = 3 Query: 2565 LQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 L T PN +L ++ T+L K +GTGAFG VY+G+W P + ++ + VA+K++ + E M+EA +MAS+ H H +RL+G+CL + L+T + G L Y+ +H+ + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ I+ITDFGLA ++ E N+ E G++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + S + P YL I D ++ Sbjct: 5 LTPSGTAPNQAQLRILKETELK---RVKILGTGAFGTVYKGIWVPEGETVK------IPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTI-QLVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLL---ETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMK 301
BLAST of epidermal growth factor receptor 2 vs. Ensembl Zebrafish
Match: si:ch73-383l1.1 (si:ch73-383l1.1 [Source:ZFIN;Acc:ZDB-GENE-121214-64]) HSP 1 Score: 246.899 bits (629), Expect = 6.466e-66 Identity = 130/358 (36.31%), Postives = 211/358 (58.94%), Query Frame = 3 Query: 2421 IILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 +I + V +++ + F I +K++++ + + + + EP L T PN +L ++ T+L K +GTGAFG VY+G+W P + ++ + VA+K++ + E M+EA +MAS+ H H +RL+G+CL + L+T + G L Y+ +H+ + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ I+ITDFGLA ++ E N+ E G++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + S + P YL I D ++ Sbjct: 646 VIGGMFVVVIVALGFAIFFRRKSIKKKRALR--RFLETELVEP-----LTPSGTAPNQAQLRILKETELK---RVKILGTGAFGTVYKGIWVPEGETVK------IPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLL---ETNEKEYSADEGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMK 983 HSP 2 Score: 105.531 bits (262), Expect = 3.114e-22 Identity = 79/257 (30.74%), Postives = 119/257 (46.30%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAI----FPKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NC V GNL I ++ + + +L FL SI EVTG + + N + L NL++IRG L + S+ I L + + + L I N VY ++KFL +I W+++ +NP+ + L+ + + C C R+ CW + CQ +K V E+ D C+ G C +C GGC GPK++DC C + + CV CP F+Y+ +L NPN K G C CP Sbjct: 54 NCEVVMGNLEITSI---ERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTK---LYEGRYSLAIFLNYRRDGYFGLRQLGLRNLTEILNGGVYVD---QNKFLCHADTIHWQDIIKNPRSELLVVPSNNSGNTCRR-CHRSCNGRCWGPQEDQCQSLTKTVCAEQCDG--RCF-----GPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCP 293 HSP 3 Score: 67.0106 bits (162), Expect = 1.611e-10 Identity = 67/249 (26.91%), Postives = 99/249 (39.76%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH---TDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYP-----PCNKP---CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCE----DEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTG 1859 V+ ITG L I + +L+ NL I S + L + T L+F LR++ G + ++ LC+ T+NWT + Q I C++ CD C GCWGPG + C +C+ F CV C D F ++ ++ D C++ L C GP P +C+ C + K+ CV+ C KY N C CH C + CTG Sbjct: 394 VREITGYLNIQSWPENMTDLSVFSNLVTIGGRTLYSGISLLILKQRWITSLQFQSLREISA--GNVYMTNNSQLCFYSTVNWTSLFRTSTQKAKIKDNRDPRECSQQRMVCDPLCSVSGCWGPGPNQCLSCKYFSRGRTCVRSCNLYNGDVREFANGSTCVEC------DSQCEKAEDKSL-TCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYPETNNECHPCHPNCTQG------CTG 626 HSP 4 Score: 61.6178 bits (148), Expect = 6.867e-9 Identity = 35/85 (41.18%), Postives = 44/85 (51.76%), Query Frame = 3 Query: 1485 CDSKCD-----SQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIG 1724 CDS+C+ S C GPG C C + NCV++C D G S I KY + ++ C CHP C Q CTGPR +CIG Sbjct: 554 CDSQCEKAEDKSLTCHGPGPDHCVKCLHLKDGPNCVEKCPD--GLQGANSFIFKYPETNNE--CHPCHPNCTQGCTGPRIQDCIG 634 HSP 5 Score: 57.7658 bits (138), Expect = 1.256e-7 Identity = 65/264 (24.62%), Postives = 104/264 (39.39%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFL--QNLKEIRHLLTQSASAALNIM-------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCN------KPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIK 1808 + K + + E V+G T+ ++ L L +++ +TG +++ L +L +NL+ IR +L I + L LGLR L I G V + LC+ADT++W +I+KN + + + P N + C C+ + CWGP C + C RC Y N CH C C GP+ T+C C F ++ CV C + F +N T + Sbjct: 47 TLRKFYENCEVVMGNLEITSIERNRNL---------SFLKSIREVTGYVLV-----ALNQFDYLPLENLRIIRGTKLYEGRYSLAIFLNYRRDGYFGLRQLGLRNLTEILNGGVYVDQNKFLCHADTIHWQ-DIIKNPRSELLVVPSNNSGNTCRRCHRSCNGR-CWGPQEDQCQSLTKTVCAEQCDGRC------------FGPYVSNC-------CHRECAGGCFGPKDTDCF-ACTNFNDSGACVTQCPQP-FVYNPTTFQ 273
BLAST of epidermal growth factor receptor 2 vs. Ensembl Zebrafish
Match: egfra (epidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) [Source:ZFIN;Acc:ZDB-GENE-030918-1]) HSP 1 Score: 244.973 bits (624), Expect = 1.240e-65 Identity = 126/299 (42.14%), Postives = 188/299 (62.88%), Query Frame = 3 Query: 2586 PNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 PN L ++ T+ K +G+GAFG V++G+W P ++++ + VA+KV+R A +EIM+EA VMASV H H RL+GICL + LIT + G L Y+R++K + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ + ++ITDFGLA ++ E E GG+VPI+W+ALE++ + Y+H++DVWS+G+T+WE+ T+G +PYD + EI L +G RL QP IC++D+Y +M +CW +A RP F L++ + + P+ YL I D Sbjct: 698 PNQALLRILKETEFK---KIKVLGSGAFGTVHKGLWVPEGENVK------IPVAIKVLREATSPKANKEIMDEAYVMASVEHPHVCRLLGICLTSTVQ-LITQLMPYGCLLDYVRENKDRIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPQHVKITDFGLAKLLNADE---KEYHADGGKVPIKWMALESIQHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFTKMARDPSRYLVIQGD 983 HSP 2 Score: 93.9745 bits (232), Expect = 3.184e-39 Identity = 73/255 (28.63%), Postives = 117/255 (45.88%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLD--EENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYN-KYMEH--QCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPN--FKLRVGYMCANSCP 904 NCT V NL I ++ E DL FL SI EV G + + N++ I L NL++IRG +SL +K ++V ++ + E+ + L I V F H +I+W ++ ++++N Y ++ +C C CW + + CQ+ +K + E C + + G C+E C GC GP+ +DC CK + + C + CP +YD +L PN K G C +CP Sbjct: 54 NCTVVLENLEITHI---TEKYDLSFLKSIQEVGGYVLIAVNTVSKIPLENLRIIRG-HSLYEDKFALAVLVNYNNSIEQGVKELPLTSLTEILKGGVRFNMN-NHLCNVGTIEWADILNMKSLPTIVSHNISYGKNCGKCDPSCFNGS---CWGTGPDKCQRMTKVI-----CAEQCSGRCK-GPRPIDCCNEHCAAGCTGPRPTDCLACKDFQDEGTCKDACPRLMLYDPNTHQLAPNPYGKYSFGATCIKTCP 294 HSP 3 Score: 90.1225 bits (222), Expect = 3.184e-39 Identity = 96/360 (26.67%), Postives = 139/360 (38.61%), Query Frame = 3 Query: 900 VQEVDACIYSCNSLHFYRVDN----KCIRCQN--SSVCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIEHVIGEFHFTAQSF--DKALGGITL-PMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQ--------FDPIYPPC---NKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRC---EDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCL-----QNCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTG 1859 V + AC+ +C S Y VD KC RC+ VC N + +V + A + +F + + G + +F D L P L V+ ITG L+I +++L+ +NL+ IR + + + T + LG+R LR I G + + LCY+ +W + K+ Q D C N C+ C + GCWGPG MC+ C + +CV C EP ++Y N C C P CL Q C GP P C C +K+ CV C + KY C CHE C + CTG Sbjct: 299 VTDHGACVRTC-SPGTYEVDEGGVRKCKRCEGLCPKVC-------NGLGMGPLANVLSINATNIDSFENCTKISGNVAILSTTFRGDPHTNTSGLDPAKLSVLSTVKEITGYLMIQLWPESMQSLSAFENLEVIRGRTKTQGTYSFAVTKTAITHLGMRSLREISDGDVSIVKNKNLCYSSPEHWK-RLFKSKQQSVKMIENMDAAT--CANQNSTCNEMCTADGCWGPGPTMCFGCEHYSRGKHCVASCNLLNGEP---------REYEVNK---TCMECDPECLLMNETQTCNGPGPDKCT-VCANYKDGPHCVHRCPQGVPGEKDTLIWKYADVTHVCQPCHENCTQG------CTG 628
BLAST of epidermal growth factor receptor 2 vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4]) HSP 1 Score: 242.662 bits (618), Expect = 6.307e-65 Identity = 165/518 (31.85%), Postives = 262/518 (50.58%), Query Frame = 3 Query: 2001 RQKSKEIGICQPCLEPCLECSGNYTIYP-TCEKCNGYWSGDRCVKQC---FPIALNLPRNASCPYCNGNCVER----CTVTPNDPFQCGSCNFKRLYLDNHNKSCVSECPQTHK------YKHKDGN----LTDIICMTRSQWLSYQENPKFISKWSLIILSVIT-VFLISSVYIFFR-YVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 R+ SKE IC P C E +G + P C C + G CVK C + + C C+ C + T P C C L+L + +CV +CP + +K+ + N C Q+ + + LI +I +F+I + + Y+ + + KK + + + + EP L PN +L ++ T+L K +G GAFG VY+G+W P + ++ + VA+K++ + E M+EA +MAS+ H H +RL+G+CL + L+T + G L Y+ +H+ + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ I+ITDFGLA ++ E N GG++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + R+I L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + S + P YL I D ++ Sbjct: 289 RECSKEQKICDPL---CSE-AGCWGPGPDQCLSCKYFSRGKTCVKSCNLYYGDVREFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKC----LHLKD-GPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQGCTGPRIQDCVGILDRTPLIAAGLIGGLFVIVIIALGVAVYIRRKSIKKKRALRRFLETELVEP-----LTPSGAAPNQAQLRILKETELK---RVKILGAGAFGMVYKGIWVPEGETVK------IPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNS---DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMK 779 HSP 2 Score: 71.633 bits (174), Expect = 6.545e-12 Identity = 66/251 (26.29%), Postives = 100/251 (39.84%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH---TDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTG--------NILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ------NCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTG 1859 V+ ITG L + + +L NL I S + L + T L+F LR++ G + ++ LC+ T+NWT ++KNN+ K CD C GCWGPG C +C+ F CV C +Y + ++++ + +C C C + C GP P +C+ C + K+ CV+ C KY N C CH C + CTG Sbjct: 190 VREITGFLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITSLQFQSLREISA--GNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNREPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYFSRGKTCVKSCNL---YYGD---VREFANG---SVCVECDSQCEKAGEKGLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQG------CTG 422 HSP 3 Score: 63.929 bits (154), Expect = 1.436e-9 Identity = 34/85 (40.00%), Postives = 44/85 (51.76%), Query Frame = 3 Query: 1485 CDSKCDSQG-----CWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIG 1724 CDS+C+ G C GPG C C + NCV++C D G S I KY + ++ C CHP C Q CTGPR +C+G Sbjct: 350 CDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPD--GLQGANSFIFKYAETNNE--CHPCHPNCTQGCTGPRIQDCVG 430 HSP 4 Score: 58.5362 bits (140), Expect = 6.463e-8 Identity = 26/65 (40.00%), Postives = 34/65 (52.31%), Query Frame = 2 Query: 716 CDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 C +C GGC GPK++DC C + + CV CP F+Y+ +L NPN K G C CP Sbjct: 25 CHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCP 89
BLAST of epidermal growth factor receptor 2 vs. Ensembl Zebrafish
Match: erbb4a (erb-b2 receptor tyrosine kinase 4a [Source:ZFIN;Acc:ZDB-GENE-030918-4]) HSP 1 Score: 242.276 bits (617), Expect = 1.562e-64 Identity = 165/518 (31.85%), Postives = 262/518 (50.58%), Query Frame = 3 Query: 2001 RQKSKEIGICQPCLEPCLECSGNYTIYP-TCEKCNGYWSGDRCVKQC---FPIALNLPRNASCPYCNGNCVER----CTVTPNDPFQCGSCNFKRLYLDNHNKSCVSECPQTHK------YKHKDGN----LTDIICMTRSQWLSYQENPKFISKWSLIILSVIT-VFLISSVYIFFR-YVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 R+ SKE IC P C E +G + P C C + G CVK C + + C C+ C + T P C C L+L + +CV +CP + +K+ + N C Q+ + + LI +I +F+I + + Y+ + + KK + + + + EP L PN +L ++ T+L K +G GAFG VY+G+W P + ++ + VA+K++ + E M+EA +MAS+ H H +RL+G+CL + L+T + G L Y+ +H+ + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ I+ITDFGLA ++ E N GG++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + R+I L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + S + P YL I D ++ Sbjct: 467 RECSKEQKICDPL---CSE-AGCWGPGPDQCLSCKYFSRGKTCVKSCNLYYGDVREFANGSVCVECDSQCEKAGEKGLTCHGPGPDHCVKC----LHLKD-GPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQGCTGPRIQDCVGILDRTPLIAAGLIGGLFVIVIIALGVAVYIRRKSIKKKRALRRFLETELVEP-----LTPSGAAPNQAQLRILKETELK---RVKILGAGAFGMVYKGIWVPEGETVK------IPVAIKILNESTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHQDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDTDEKEYNS---DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTRDIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFSRMARDPQRYLVIQGDDRMK 957 HSP 2 Score: 104.76 bits (260), Expect = 4.440e-22 Identity = 79/257 (30.74%), Postives = 118/257 (45.91%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAI----FPKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NC V GNL I ++ + + +L FL SI EVTG + + N + L NL++IRG L + S+ I L + + + L I N VY ++KFL +I W ++ +NP+ + L+ + + C C R+ CW + CQ +K V E+ D C+ G C +C GGC GPK++DC C + + CV CP F+Y+ +L NPN K G C CP Sbjct: 28 NCEVVMGNLEITSI---ERNRNLSFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTK---LYEGRYSLAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVD---QNKFLCHADTIHWHDIIKNPRSELLVVPSNNSGNTCRR-CHRSCNGRCWGHQEDQCQSLTKTVCAEQCDG--RCF-----GPYVSNCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPNAKYTYGAFCVKKCP 267 HSP 3 Score: 71.2478 bits (173), Expect = 8.074e-12 Identity = 66/251 (26.29%), Postives = 100/251 (39.84%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH---TDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTG--------NILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ------NCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTG 1859 V+ ITG L + + +L NL I S + L + T L+F LR++ G + ++ LC+ T+NWT ++KNN+ K CD C GCWGPG C +C+ F CV C +Y + ++++ + +C C C + C GP P +C+ C + K+ CV+ C KY N C CH C + CTG Sbjct: 368 VREITGFLNVQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITSLQFQSLREISA--GNVYMTNNSQLCFYSTVNWTSLFRTSTQRALIKNNREPRECSKEQKICDPLCSEAGCWGPGPDQCLSCKYFSRGKTCVKSCNL---YYGD---VREFANG---SVCVECDSQCEKAGEKGLTCHGPGPDHCV-KCLHLKDGPNCVEKCPDGLQGANSFIFKYAETNNECHPCHPNCTQG------CTG 600 HSP 4 Score: 63.5438 bits (153), Expect = 1.716e-9 Identity = 34/85 (40.00%), Postives = 44/85 (51.76%), Query Frame = 3 Query: 1485 CDSKCDSQG-----CWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIG 1724 CDS+C+ G C GPG C C + NCV++C D G S I KY + ++ C CHP C Q CTGPR +C+G Sbjct: 528 CDSQCEKAGEKGLTCHGPGPDHCVKCLHLKDGPNCVEKCPD--GLQGANSFIFKYAETNNE--CHPCHPNCTQGCTGPRIQDCVG 608 HSP 5 Score: 56.6102 bits (135), Expect = 2.531e-7 Identity = 91/407 (22.36%), Postives = 151/407 (37.10%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFL--QNLKEIRHLLTQSASAALNIM-------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCN------KPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQ 2237 + K + + E V+G T+ ++ L L +++ +TG +++ L +L +NL+ IR +L I + L LGL+ L I G V + LC+ADT++W +I+KN + + + P N + C C+ + CWG C + C RC Y N CH C C GP+ T+C C F ++ CV C + F +N T + +E++ N G ++C K K F C R NK+++ E + +C PC + C + C+G +G + Q + N+ + +C NGN + T D F Sbjct: 21 TLRKFYENCEVVMGNLEITSIERNRNL---------SFLKSIREVTGYVLV-----ALNQFDYLPLENLRIIRGTKLYEGRYSLAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQNKFLCHADTIHWH-DIIKNPRSELLVVPSNNSGNTCRRCHRSCNGR-CWGHQEDQCQSLTKTVCAEQCDGRC------------FGPYVSNC-------CHRECAGGCFGPKDTDCF-ACTNFNDSGACVTQCPQP-FVYNPTTFQ-----LEHNPNAKYTYG----------AFCVK---KCPHNFVVDHSSCVRACPSNKMEVEE-------NQTKMCIPCTDICPKV------------CDGIGTGSLQMAQTVDSS-NIEKFVNCTKINGNLIFLITGIKGDMFH 352
BLAST of epidermal growth factor receptor 2 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853]) HSP 1 Score: 261.922 bits (668), Expect = 7.225e-71 Identity = 175/530 (33.02%), Postives = 281/530 (53.02%), Query Frame = 3 Query: 2058 CSGNYTIYP---TCEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCV-ERCTVTPN--DPFQCGSCNFKRLYLDNHNKSCVSECPQTHK-------YKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLIS--------------SVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDI-QEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCL---RPMKKDKHR-LLSQISYD 3539 C GN P C +CNG+ G C++ C + PR + C C+ C+ + T+T N + QC C YLD + CV +CP K +K+ D D IC + S+ S I +S + V++++ ++ ++ R ++ +K +++ L + + EP L IPN ++ ++ T+L +G+GAFG VY+G+W P ++++ + VA+KV+R N + +EI++EA VMA V + RL+GICL + L+T + G L Y+R++K + SR LL+W QIA GMTYLE ++HRDLA RNVL+ ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP +C++D+Y +M +CW ++ RP F L+ LS + P+ Y+ I N+ L PM + LL ++ D Sbjct: 481 CDGNKCWGPGPSQCVRCNGFLRGHDCIESCN-VLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAH---YLDGED--CVEQCPSGVKGNSFVPIWKYPD---KDRICQLCNVNCSH-------SYVMFIGISTVQVYMVASIVISILIVITISTAIVLYIRRRKQLKKKHTMRRL--LQDELVEP-----LTPSGAIPNQAQMRILKETELK---KMMILGSGAFGTVYKGIWIPDGENIK------IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLTSTVQ-LVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDE---TEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQASPMTTQFYSALLQEVGMD 974 HSP 2 Score: 89.3521 bits (220), Expect = 3.137e-17 Identity = 69/261 (26.44%), Postives = 115/261 (44.06%), Query Frame = 3 Query: 1056 MTAAILKNFTDIEHVIGEFHFTAQSF-------DKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKP---------CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGI-CQRCHPLCL-QN----CTGPRPTNCIGGCRYFKENDECVKNC 1769 + A+I+ +F + G F ++SF + L +L + ++ ITG + I+ LK+L +NL+ I + Q+ + +L + + + LGLR L + G + +P LC+ ++ W L N I NKP C S+CD CWGPG C C GF ++C++ C + + Y + +G C CHP CL QN C G C+ C ++ + ++CV+ C Sbjct: 323 VNASIIHHFQGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVF----KTLEEITGYIYIESWPEELKSLNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWAS--LFRNPRQTILKTINKPQEAYQEGQNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIESC----------NVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCM-ECAHYLDGEDCVEQC 566 HSP 3 Score: 67.0106 bits (162), Expect = 2.458e-10 Identity = 70/266 (26.32%), Postives = 109/266 (40.98%), Query Frame = 2 Query: 158 HNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSV---YFKTKVKHKFLPQSIKWEELFENPKKQKLITYNK------------YMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGN--TKLNPNFKLRVGYMCANSCP 904 +C ++GNL I + +E D+ FL I EV G + + +N + + L NL++IRG L E+ ++V L + + S A K VI N+ + T + L Q + L + P I++ + +C C FP +S+ + S C + K ++ C C EQC GC GPKNSDC C + + C +CPP Y+ + N + G C SCP Sbjct: 30 RDCQVIQGNLEITYL---KEDNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRG-TQLYQERYALAV---LSNSDPSGTAEILKGGVIMENNTQLCFQDTVLWADILSQILSRIMLLQIPPPYFQISHTGRNFMCFASGAGLAIRCECFVSC---SFPLPVTSTICN----SGCQRCKGNHSTHC-------------CHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCP 268 HSP 4 Score: 55.0694 bits (131), Expect = 1.032e-6 Identity = 66/249 (26.51%), Postives = 105/249 (42.17%), Query Frame = 2 Query: 158 HNCTHVEGNLVI--QNVWPDQE-------SGDLGFLSSIIEVTGMIFMKN--NSIKDI-ILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNK----YMEHQ-CHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQC------------TGGCNGPKNSDCAVCKKYVNGNHCVEYCP 817 CT + G+LV ++ PD + L ++ E+TG I++++ +K + + NL+VI G+ L+ S+ +L + + L +++ V + FL +S W LF NP++ L T NK Y E Q C S C N CW + C + + ++ D IE C + +G E QC T CNG + C C Y++G CVE CP Sbjct: 332 QGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFKTLEEITGYIYIESWPEELKSLNVFENLRVIHGR---MLQNGAYSL---VLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFL-ESAPWASLFRNPRQTILKTINKPQEAYQEGQNCFSRCDGNK---CWGPGPSQCVRCNGFLRGH-DCIESC--NVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAHYLDGEDCVEQCP 567
BLAST of epidermal growth factor receptor 2 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853]) HSP 1 Score: 260.381 bits (664), Expect = 8.216e-71 Identity = 236/832 (28.37%), Postives = 369/832 (44.35%), Query Frame = 3 Query: 1215 IDGSNIVLKNL---TFLQNLKEIRHLLTQSASAALNIMHTD--LEFLGLRKLRR------IFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRC---------HPLCLQNCTGPRPTNCIGGCRYFKEND-------------------------------ECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYP---TCEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCV-ERCTVTPN--DPFQCGSCNFKRLYLDNHNKSCVSECPQTHK-------YKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITV-----------FLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDI-QEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNI 3470 + G ++ NL L+NL+ IR AL ++ GLR+LR + G + ++ LC+ DT+ W +IL+ N MC+ A+ RCE + + S T + CQRC H C CTGP+ ++C+ C +F N CV +C KYF N I T E L G + L + S + PR L I+ + Q+ Q C C GN P C +CNG+ G C++ C + PR + C C+ C+ + T+T N + QC C YLD + CV +CP K +K+ D D IC + S+ FI S ++ V V + +++ ++ R ++ +K +++ L + + EP L IPN ++ ++ T+L +G+GAFG VY+G+W P ++++ + VA+KV+R N + +EI++EA VMA V + RL+GICL + L+T + G L Y+R++K + SR LL+W QIA GMTYLE ++HRDLA RNVL+ ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP +C++D+Y +M +CW ++ RP F L+ LS + P+ Y+ I Sbjct: 59 VQGYVLIAHNLLSYVPLENLRIIRGTQLYQERYALAVLSNSDPSGTAGLRELRMKNLTEILKGGVIMENNTQLCFQDTVLWA-DILRRN---------------------------FMCFASGAGLAI-----RCE----CFVSCSFPLPVTSTICNSGCQRCKGNHSTHCCHEQCAAGCTGPKNSDCLA-CLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCPCKYFLLN--IIGHKATFQEVSSGLVLIEGNPDLCFLESAPWASLFRN-------------PRQTILKTINKPQEACDQEG------QNCFS---RCDGNKCWGPGPSQCVRCNGFLRGHDCIESC-NVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAH---YLDGED--CVEQCPSGVKGNSFVPIWKYPD---KDRICQLCNVNCSH-SYVMFIG-ISTVLYQVYMVASIVISILIVITISTAIVLYIRRRKQLKKKHTMRRL--LQDELVEP-----LTPSGAIPNQAQMRILKETELK---KMMILGSGAFGTVYKGIWIPDGENIK------IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLTSTVQ-LVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDE---TEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVI 797 HSP 2 Score: 68.1662 bits (165), Expect = 1.020e-10 Identity = 70/255 (27.45%), Postives = 107/255 (41.96%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSAN---HCQKQSKCVKEKVDNIEWCYFKMRN--GEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIY--DRGNTKLNPNFKLRVGYMCANSCP 904 +C ++GNL I + +E D+ FL I EV G + + +N + + L NL++IRG L E+ ++V L + + S A +LR+ K L + +K + EN T + + +D LR +F C++S A C+ C C + G C EQC GC GPKNSDC C + + C +CPP Y + + N + G C SCP Sbjct: 31 DCQVIQGNLEITYL---KEDNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRG-TQLYQERYALAV---LSNSDPSGTAGLRELRM--------------KNLTEILKGGVIMENN------TQLCFQDTVLWADILRRNF-MCFASGAGLAIRCECFVSCSFPLPVTSTICNSGCQRCKGNHSTHCCHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCP 257
BLAST of epidermal growth factor receptor 2 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853]) HSP 1 Score: 261.536 bits (667), Expect = 8.803e-71 Identity = 175/519 (33.72%), Postives = 280/519 (53.95%), Query Frame = 3 Query: 2058 CSGNYTIYP---TCEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCV-ERCTVTPN--DPFQCGSCNFKRLYLDNHNKSCVSECPQTHK-------YKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLI---SSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDI-QEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCL---RPMKKDKHR-LLSQISYD 3539 C GN P C +CNG+ G C++ C + PR + C C+ C+ + T+T N + QC C YLD + CV +CP K +K+ D D IC + S+ N W L + + + +I +++ ++ R ++ +K +++ L + + EP L IPN ++ ++ T+L +G+GAFG VY+G+W P ++++ + VA+KV+R N + +EI++EA VMA V + RL+GICL + L+T + G L Y+R++K + SR LL+W QIA GMTYLE ++HRDLA RNVL+ ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP +C++D+Y +M +CW ++ RP F L+ LS + P+ Y+ I N+ L PM + LL ++ D Sbjct: 507 CDGNKCWGPGPSQCVRCNGFLRGHDCIESCN-VLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAH---YLDGED--CVEQCPSGVKGNSFVPIWKYPD---KDRICQLCNVNCSHSCNQLDERVWRLTSIVISILIVITISTAIVLYIRRRKQLKKKHTMRRL--LQDELVEP-----LTPSGAIPNQAQMRILKETELK---KMMILGSGAFGTVYKGIWIPDGENIK------IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLTSTVQ-LVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDE---TEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQASPMTTQFYSALLQEVGMD 996 HSP 2 Score: 89.3521 bits (220), Expect = 3.770e-17 Identity = 74/291 (25.43%), Postives = 123/291 (42.27%), Query Frame = 3 Query: 1056 MTAAILKNFTDIEHVIGEFHFTAQSF-------DKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKP----------CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGI-CQRCHPLCL-QN----CTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETC 1823 + A+I+ +F + G F ++SF + L +L + ++ ITG + I+ LK+L +NL+ I + Q+ + +L + + + LGLR L + G + +P LC+ ++ W L N I NKP C S+CD CWGPG C C GF ++C++ C + + Y + +G C CHP CL QN C G C+ C ++ + ++CV+ C KY ++ C C+ C Sbjct: 348 VNASIIHHFQGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFK----TLEEITGYIYIESWPEELKSLNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWAS--LFRNPRQTILKTINKPQEACDQEGQNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIESC----------NVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCM-ECAHYLDGEDCVEQCPSGVKGNSFVPIWKYPDKDRICQLCNVNC 621 HSP 3 Score: 75.485 bits (184), Expect = 6.105e-13 Identity = 69/268 (25.75%), Postives = 108/268 (40.30%), Query Frame = 2 Query: 158 HNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRV-----IANNSVYFKTKVKHKFLPQSIKWEELFENPKKQK-LITYNKYMEHQCHSDCLRNDFP-----YCWSSSANHCQK------QSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGN--TKLNPNFKLRVGYMCANSCP 904 +C ++GNL I + +E D+ FL I EV G + + +N + + L NL++IRG L E+ ++V L + + S A +LR+ I V + + F ++ W ++ Q+ + C C P +CW +CQ S C + K ++ C C EQC GC GPKNSDC C + + C +CPP Y+ + N + G C SCP Sbjct: 49 RDCQVIQGNLEITYL---KEDNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRG-TQLYQERYALAV---LSNSDPSGTAGLRELRMKNLTEILKGGVIMENNTQLCF-QDTVLWADILSQSNSQRNEVVLGSSNRPTCSPGC--GSLPSGKSGFCWGEGQEYCQILTSTICNSGCQRCKGNHSTHC-------------CHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCP 293 HSP 4 Score: 53.1434 bits (126), Expect = 3.647e-6 Identity = 64/250 (25.60%), Postives = 103/250 (41.20%), Query Frame = 2 Query: 158 HNCTHVEGNLVI--QNVWPDQE-------SGDLGFLSSIIEVTGMIFMKN--NSIKDI-ILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYME------HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQC------------TGGCNGPKNSDCAVCKKYVNGNHCVEYCP 817 CT + G+LV ++ PD + L ++ E+TG I++++ +K + + NL+VI G+ L+ S+ +L + + L +++ V + FL +S W LF NP++ L T NK E C S C N CW + C + + ++ D IE C + +G E QC T CNG + C C Y++G CVE CP Sbjct: 357 QGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFKTLEEITGYIYIESWPEELKSLNVFENLRVIHGR---MLQNGAYSL---VLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFL-ESAPWASLFRNPRQTILKTINKPQEACDQEGQNCFSRCDGNK---CWGPGPSQCVRCNGFLRGH-DCIESC--NVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAHYLDGEDCVEQCP 593
BLAST of epidermal growth factor receptor 2 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853]) HSP 1 Score: 261.536 bits (667), Expect = 1.077e-70 Identity = 175/519 (33.72%), Postives = 280/519 (53.95%), Query Frame = 3 Query: 2058 CSGNYTIYP---TCEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCV-ERCTVTPN--DPFQCGSCNFKRLYLDNHNKSCVSECPQTHK-------YKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLI---SSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDI-QEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCL---RPMKKDKHR-LLSQISYD 3539 C GN P C +CNG+ G C++ C + PR + C C+ C+ + T+T N + QC C YLD + CV +CP K +K+ D D IC + S+ N W L + + + +I +++ ++ R ++ +K +++ L + + EP L IPN ++ ++ T+L +G+GAFG VY+G+W P ++++ + VA+KV+R N + +EI++EA VMA V + RL+GICL + L+T + G L Y+R++K + SR LL+W QIA GMTYLE ++HRDLA RNVL+ ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP +C++D+Y +M +CW ++ RP F L+ LS + P+ Y+ I N+ L PM + LL ++ D Sbjct: 514 CDGNKCWGPGPSQCVRCNGFLRGHDCIESCN-VLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAH---YLDGED--CVEQCPSGVKGNSFVPIWKYPD---KDRICQLCNVNCSHSCNQLDERVWRLTSIVISILIVITISTAIVLYIRRRKQLKKKHTMRRL--LQDELVEP-----LTPSGAIPNQAQMRILKETELK---KMMILGSGAFGTVYKGIWIPDGENIK------IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLTSTVQ-LVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDE---TEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQASPMTTQFYSALLQEVGMD 1003 HSP 2 Score: 89.3521 bits (220), Expect = 3.717e-17 Identity = 69/262 (26.34%), Postives = 115/262 (43.89%), Query Frame = 3 Query: 1056 MTAAILKNFTDIEHVIGEFHFTAQSF-------DKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKP----------CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGI-CQRCHPLCL-QN----CTGPRPTNCIGGCRYFKENDECVKNC 1769 + A+I+ +F + G F ++SF + L +L + ++ ITG + I+ LK+L +NL+ I + Q+ + +L + + + LGLR L + G + +P LC+ ++ W L N I NKP C S+CD CWGPG C C GF ++C++ C + + Y + +G C CHP CL QN C G C+ C ++ + ++CV+ C Sbjct: 355 VNASIIHHFQGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFK----TLEEITGYIYIESWPEELKSLNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWAS--LFRNPRQTILKTINKPQEACDQEGQNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIESC----------NVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCM-ECAHYLDGEDCVEQC 599 HSP 3 Score: 75.0998 bits (183), Expect = 7.887e-13 Identity = 69/268 (25.75%), Postives = 108/268 (40.30%), Query Frame = 2 Query: 158 HNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRV-----IANNSVYFKTKVKHKFLPQSIKWEELFENPKKQK-LITYNKYMEHQCHSDCLRNDFP-----YCWSSSANHCQK------QSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGN--TKLNPNFKLRVGYMCANSCP 904 +C ++GNL I + +E D+ FL I EV G + + +N + + L NL++IRG L E+ ++V L + + S A +LR+ I V + + F ++ W ++ Q+ + C C P +CW +CQ S C + K ++ C C EQC GC GPKNSDC C + + C +CPP Y+ + N + G C SCP Sbjct: 56 RDCQVIQGNLEITYL---KEDNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRG-TQLYQERYALAV---LSNSDPSGTAGLRELRMKNLTEILKGGVIMENNTQLCF-QDTVLWADILSQSNSQRNEVVLGSSNRPTCSPGC--GSLPSGKSGFCWGEGQEYCQILTSTICNSGCQRCKGNHSTHC-------------CHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCP 300 HSP 4 Score: 53.1434 bits (126), Expect = 4.251e-6 Identity = 64/250 (25.60%), Postives = 103/250 (41.20%), Query Frame = 2 Query: 158 HNCTHVEGNLVI--QNVWPDQE-------SGDLGFLSSIIEVTGMIFMKN--NSIKDI-ILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYME------HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQC------------TGGCNGPKNSDCAVCKKYVNGNHCVEYCP 817 CT + G+LV ++ PD + L ++ E+TG I++++ +K + + NL+VI G+ L+ S+ +L + + L +++ V + FL +S W LF NP++ L T NK E C S C N CW + C + + ++ D IE C + +G E QC T CNG + C C Y++G CVE CP Sbjct: 364 QGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFKTLEEITGYIYIESWPEELKSLNVFENLRVIHGR---MLQNGAYSL---VLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFL-ESAPWASLFRNPRQTILKTINKPQEACDQEGQNCFSRCDGNK---CWGPGPSQCVRCNGFLRGH-DCIESC--NVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAHYLDGEDCVEQCP 600
BLAST of epidermal growth factor receptor 2 vs. Ensembl Xenopus
Match: gnb5 (guanine nucleotide binding protein (G protein), beta 5 [Source:Xenbase;Acc:XB-GENE-977853]) HSP 1 Score: 261.536 bits (667), Expect = 1.545e-70 Identity = 173/526 (32.89%), Postives = 280/526 (53.23%), Query Frame = 3 Query: 2058 CSGNYTIYP---TCEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCV-ERCTVTPN--DPFQCGSCNFKRLYLDNHNKSCVSECPQ---------THKYKHKDG--NLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLI------SSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDI-QEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCL---RPMKKDKHR-LLSQISYD 3539 C GN P C +CNG+ G C++ C + PR + C C+ C+ + T+T N + QC C YLD + CV +CP KY KD L ++ C L + P + +++ I + ++ +++ ++ R ++ +K +++ L + + EP L IPN ++ ++ T+L +G+GAFG VY+G+W P ++++ + VA+KV+R N + +EI++EA VMA V + RL+GICL + L+T + G L Y+R++K + SR LL+W QIA GMTYLE ++HRDLA RNVL+ ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP +C++D+Y +M +CW ++ RP F L+ LS + P+ Y+ I N+ L PM + LL ++ D Sbjct: 515 CDGNKCWGPGPSQCVRCNGFLRGHDCIESCN-VLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAH---YLDGED--CVEQCPSGVKGNSFVPIWKYPDKDRICQLCNVNCSHSCNQLDERGCPILPDNSQVYMVASIVISILIVITISTAIVLYIRRRKQLKKKHTMRRL--LQDELVEP-----LTPSGAIPNQAQMRILKETELK---KMMILGSGAFGTVYKGIWIPDGENIK------IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVCRLLGICLTSTVQ-LVTQLMPYGCLLDYVRENKDRIASRDLLNWCVQIAKGMTYLEDVRLVHRDLAARNVLVKSPSHVKITDFGLARLLDVDE---TEYHADGGKVPIKWMALESILHRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPVCTIDVYMIMVKCWMIDSEFRPKFRDLVGELSRMARDPSRYVVIENEEFLAQASPMTTQFYSALLQEVGMD 1014 HSP 2 Score: 89.3521 bits (220), Expect = 3.503e-17 Identity = 69/262 (26.34%), Postives = 115/262 (43.89%), Query Frame = 3 Query: 1056 MTAAILKNFTDIEHVIGEFHFTAQSF-------DKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKP----------CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGI-CQRCHPLCL-QN----CTGPRPTNCIGGCRYFKENDECVKNC 1769 + A+I+ +F + G F ++SF + L +L + ++ ITG + I+ LK+L +NL+ I + Q+ + +L + + + LGLR L + G + +P LC+ ++ W L N I NKP C S+CD CWGPG C C GF ++C++ C + + Y + +G C CHP CL QN C G C+ C ++ + ++CV+ C Sbjct: 356 VNASIIHHFQGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFK----TLEEITGYIYIESWPEELKSLNVFENLRVIHGRMLQNGAYSLVLRNLSISHLGLRSLTEVSSGLVLIEGNPDLCFLESAPWAS--LFRNPRQTILKTINKPQEACDQEGQNCFSRCDGNKCWGPGPSQCVRCNGFLRGHDCIESC----------NVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCM-ECAHYLDGEDCVEQC 600 HSP 3 Score: 73.559 bits (179), Expect = 2.253e-12 Identity = 69/270 (25.56%), Postives = 110/270 (40.74%), Query Frame = 2 Query: 158 HNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRV-----IANNSVYFKTKVKHKFLPQSIKWEELFENPKKQK---LITYNKYMEHQCHSDCLRNDFP-----YCWSSSANHCQK------QSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGN--TKLNPNFKLRVGYMCANSCP 904 +C ++GNL I + +E D+ FL I EV G + + +N + + L NL++IRG L E+ ++V L + + S A +LR+ I V + + F ++ W ++ Q+ ++ + C C P +CW +CQ S C + K ++ C C EQC GC GPKNSDC C + + C +CPP Y+ + N + G C SCP Sbjct: 55 RDCQVIQGNLEITYL---KEDNDVSFLKDIKEVQGYVLIAHNLLSYVPLENLRIIRG-TQLYQERYALAV---LSNSDPSGTAGLRELRMKNLTEILKGGVIMENNTQLCF-QDTVLWADILSQSNSQRNEVVLGSSNRQCPTCSPGC--GSLPSGKSGFCWGEGQEYCQILTSTICNSGCQRCKGNHSTHC-------------CHEQCAAGCTGPKNSDCLACLHFNHNGVCGLHCPPLRTYNPETYESVHNEGGRYTFGASCVTSCP 301 HSP 4 Score: 52.7582 bits (125), Expect = 5.199e-6 Identity = 64/250 (25.60%), Postives = 103/250 (41.20%), Query Frame = 2 Query: 158 HNCTHVEGNLVI--QNVWPDQE-------SGDLGFLSSIIEVTGMIFMKN--NSIKDI-ILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYME------HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQC------------TGGCNGPKNSDCAVCKKYVNGNHCVEYCP 817 CT + G+LV ++ PD + L ++ E+TG I++++ +K + + NL+VI G+ L+ S+ + L + + L +++ V + FL +S W LF NP++ L T NK E C S C D CW + C + + ++ D IE C + +G E QC T CNG + C C Y++G CVE CP Sbjct: 365 QGCTKIFGSLVFLSESFKPDPNKPNSVLNAQSLEVFKTLEEITGYIYIESWPEELKSLNVFENLRVIHGR---MLQNGAYSLVLRNL---SISHLGLRSLTEVSSGLVLIEGNPDLCFL-ESAPWASLFRNPRQTILKTINKPQEACDQEGQNCFSRC---DGNKCWGPGPSQCVRCNGFLRGH-DCIESC--NVLDGYPREHVNGSQCVPCHPQCLPQNGTLTCNGTEAHQCMECAHYLDGEDCVEQCP 601
BLAST of epidermal growth factor receptor 2 vs. Ensembl Mouse
Match: Egfr (epidermal growth factor receptor [Source:MGI Symbol;Acc:MGI:95294]) HSP 1 Score: 259.996 bits (663), Expect = 2.040e-70 Identity = 167/489 (34.15%), Postives = 256/489 (52.35%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCVERC---TVTPNDPFQCGSCNFKRLYLDNHNKSCVSECP-------QTHKYKHKDGNLTDIICMTRSQW----------LSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C C G CV++C I PR N+ C C+ C+ + T T P C C Y+D + CV CP T +K+ D N +C + + PK S + I+ ++ + +++ F I +K++++ L + E + L PN L ++ T+ K +G+GAFG VY+G+W P + ++ + VA+K +R A +EI++EA VMASV + H RL+GICL + LIT + G L Y+R+HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ + ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ IY+H++DVWS+G+T+WE+ T+G +PYD + +I+S L +G RL QP IC++D+Y +M +CW +A+ RP F L+ S + P YL I D Sbjct: 523 CVSCQNVSRGRECVEKCN-ILEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAH---YIDGPH--CVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYGCAGPGLQGCEVWPSGPKIPSIATGIVGGLLFIVVVALGIGLFMRRRHIVRKRTLRRL------LQERELVEPLTPSGEAPNQAHLRILKETEFK---KIKVLGSGAFGTVYKGLWIPEGEKVK------IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPYGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEE---KEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASDISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELILEFSKMARDPQRYLVIQGD 986 HSP 2 Score: 102.449 bits (254), Expect = 2.902e-21 Identity = 88/313 (28.12%), Postives = 129/313 (41.21%), Query Frame = 3 Query: 1044 DVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHL---GNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNW--------TGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRC---EDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ-----NCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGC 1889 D + A +K+F + G+ H +F T P+ + L V+ ITG L+I +L +NL+ IR Q +L ++ ++ LGLR L+ I G + + LCYA+T+NW + NN+ + N C+ C S+GCWGP C +C+ CV++C E EP +++ +N + C +CHP CL CTG P NCI C ++ + CVK C KY N C CH C C G GL GC Sbjct: 347 DTLSINATNIKHFKYCTAISGDLHILPVAFKGDSFTRTPPLDPRELEILKTVKEITGFLLIQAWPDNWTDLHAFENLEIIRGRTKQHGQFSLAVVGLNITSLGLRSLKEISDGDVIISGNRNLCYANTINWKKLFGTPNQKTKIMNNRAEKDCKAVNHVCNPLCSSEGCWGPEPRDCVSCQNVSRGRECVEKCNILEGEP---------REFVENSE---CIQCHPECLPQAMNITCTGRGPDNCI-QCAHYIDGPHCVKTCPAGIMGENNTLVWKYADANNVCHLCHANCTYG------CAGP----GLQGC 636 HSP 3 Score: 94.7449 bits (234), Expect = 5.877e-19 Identity = 80/266 (30.08%), Postives = 121/266 (45.49%), Query Frame = 2 Query: 158 HNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRG----QNSLALEKSEVSVY------IDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCH-SDCLRNDFP----YCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 +NC V GNL I V Q + DL FL +I EV G + + N+++ I L NL++IRG +N+ AL + +S Y + L N Q + +R +NN + +I+W ++ +N + N M+ Q H S C + D CW +CQK +K + + C + R G C QC GC GP+ SDC VC+K+ + C + CPP +Y+ ++ NP K G C CP Sbjct: 56 NNCEVVLGNLEITYV---QRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNALYENTYAL--AILSNYGTNRTGLRELPMRNLQEILIGAVR-FSNNPILCNM--------DTIQWRDIVQN-----VFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICA-----QQCSHRCR-GRSPSDCCHNQCAAGCTGPRESDCLVCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCP 296 HSP 4 Score: 57.3806 bits (137), Expect = 1.396e-7 Identity = 60/238 (25.21%), Postives = 89/238 (37.39%), Query Frame = 3 Query: 1179 LGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIM------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNI----LKNNQFDPIYPPCNKP-CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNC----------------SRKYFSFNKTCIK 1808 L +Q + G ++I + + L+NL+ IR + AL I+ T L L +R L+ I G ++P LC DT+ W + + N D P + P CD C + CWG G C C RC + +D C CH C CTGPR ++C+ C+ F++ C C +SF TC+K Sbjct: 79 LKTIQEVAGYVLIALNTV---ERIPLENLQIIRGNALYENTYALAILSNYGTNRTGLRELPMRNLQEILIGAVRFSNNPILCNMDTIQWRDIVQNVFMSNMSMDLQSHPSSCPKCDPSCPNGSCWGGGEENCQKLTKIICAQQCSHRCRG-----------RSPSD------C--CHNQCAAGCTGPRESDCL-VCQKFQDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVK 293
BLAST of epidermal growth factor receptor 2 vs. Ensembl Mouse
Match: Erbb2 (erb-b2 receptor tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:95410]) HSP 1 Score: 251.136 bits (640), Expect = 1.939e-67 Identity = 165/488 (33.81%), Postives = 259/488 (53.07%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNC-----VERCTVTPNDPFQCGSCNFKRLYLDNHNKSCVSECPQ----------THKYKHKDG--NLTDIICMTRSQWLSYQENP--KFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDI-QEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C C+ + G CV++C + LPR C C+ C E C + D QC +C Y D+ SCV+ CP KY ++G I C L + P + S + II +V+ V L + + + K ++K KY + + E + L +PN ++ ++ T+L K +G+GAFG VY+G+W P ++++ + VA+KV+R N + +EI++EA VMA V + RL+GICL + L+T + G L ++R+H+ L S+ LL+W QIA GM+YLE ++HRDLA RNVL+ ++ITDFGLA ++ E E GG+VPI+W+ALE++L ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP IC++D+Y +M +CW ++ RP F L+S S + P ++ I N+ Sbjct: 529 CVNCSQFLRGQECVEECR-VWKGLPREYVRGKHCLPCHPECQPQNSSETCYGSEAD--QCEACAH---YKDS--SSCVARCPSGVKPDLSYMPIWKYPDEEGICQPCPINCTHSCVDLDERGCPAEQRASPVTFIIATVVGVLLFLIIVVVIGILIKRRRQKIRKY--TMRRLLQETELVEPLTPSGAVPNQAQMRILKETELR---KLKVLGSGAFGTVYKGIWIPDGENVK------IPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQ-LVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDE---TEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVSEFSRMARDPQRFVVIQNE 993 HSP 2 Score: 87.8113 bits (216), Expect = 7.009e-17 Identity = 68/257 (26.46%), Postives = 106/257 (41.25%), Query Frame = 3 Query: 1056 MTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLG---NVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKP----------CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCL-----QNCTGPRPTNCIGGCRYFKENDECVKNC 1769 +T+ ++ F + + G F +SFD P+ +HL ++ ITG L I ++L+ QNL+ IR + + +L + + LGLR LR + G +H + LC+ +T+ W + L N + N+P C+S C CWGPG C NC F CV+ C G ++Y C CHP C + C G C C ++K++ CV C Sbjct: 357 ITSDNIQEFAGCKKIFGSLAFLPESFDGNPSSGVAPLKPEHLQVFETLEEITGYLYISAWPESFQDLSVFQNLRVIRGRILHDGAYSLTLQGLGIHSLGLRSLRELGSGLALIHRNTHLCFVNTVPW--DQLFRNPHQALLHSGNRPEEACGLEGLVCNSLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVWKGL------PREYVRGKH---CLPCHPECQPQNSSETCYGSEADQC-EACAHYKDSSSCVARC 601 HSP 3 Score: 72.4034 bits (176), Expect = 4.525e-12 Identity = 67/269 (24.91%), Postives = 105/269 (39.03%), Query Frame = 2 Query: 158 HNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPK-----LRVIANNSV--YFKTKVKHKFLPQ-----SIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQK------QSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIY--DRGNTKLNPNFKLRVGYMCANSCP 904 C V+GNL + + + L FL I EV G + + +N +K + L L+++RG L +K ++V +D D ++ P LR + S+ K V + PQ + W+++ + + + C +CW S CQ S C + K G + C EQC GC GPK+SDC C + + C +CP Y D + LNP + G C +CP Sbjct: 51 QGCQVVQGNLELTYL---PANASLSFLQDIQEVQGYMLIAHNRVKHVPLQRLRIVRG-TQLFEDKYALAV-LDNRDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCARCK-------------GRLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALITYNTDTFESMLNPEGRYTFGASCVTTCP 301 HSP 4 Score: 55.4546 bits (132), Expect = 5.679e-7 Identity = 48/171 (28.07%), Postives = 64/171 (37.43%), Query Frame = 3 Query: 1275 RHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNK-----PCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNC 1769 R L +AA L L LR L I G + +P LCY D + W + KNNQ P+ N+ PC C CWG C G C RC+ + TD CH C CTGP+ ++C+ C +F + C +C Sbjct: 120 RDPLDNVTTAAPGRTPEGLRELQLRSLTEILKGGVLIRGNPQLCYQDMVLWKDVLRKNNQLAPVDMDTNRSRACPPCAPTCKDNHCWGESPEDCQILTGTICTSGCA-RCKG-----------RLPTDC--------CHEQCAAGCTGPKHSDCL-ACLHFNHSGICELHC 269
BLAST of epidermal growth factor receptor 2 vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771]) HSP 1 Score: 249.21 bits (635), Expect = 1.042e-66 Identity = 136/376 (36.17%), Postives = 214/376 (56.91%), Query Frame = 3 Query: 2373 WLSYQENPKFISKWSLIILSVIT--VFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 W + P+ ++ LI VI L+ F YV + + KK + + + + EP L T PN +L ++ T+L K +G+GAFG VY+G+W P + ++ + VA+K++ E M+EA +MAS+ H H +RL+G+CL + L+T + G L Y+ +HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ ++ITDFGLA ++ E ++ E GG++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + S + P YL I D ++ Sbjct: 638 WTGHSTLPQH-ARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETELVEP-----LTPSGTAPNQAQLRILKETELK---RVKVLGSGAFGTVYKGIWVPEGETVK------IPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL---EGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK 994 HSP 2 Score: 110.153 bits (274), Expect = 1.296e-23 Identity = 81/258 (31.40%), Postives = 122/258 (47.29%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEEN--SQYAIFPKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENP--KKQKLITYNKYME-HQCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNF--KLRVGYMCANSCP 904 NC V GNL I ++ + + DL FL SI EVTG + + N + + L NL++IRG L ++ ++++++ + N Q L I N VY ++KFL +I W+++ NP L++ N +CH C CW + NHCQ ++ V E+ D CY G C +C GGC+GPK++DC C + + CV CP F+Y+ +L NF K G C CP Sbjct: 55 NCEVVMGNLEITSI---EHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVD---QNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGRCHKSCTGR----CWGPTENHCQTLTRTVCAEQCDG--RCY-----GPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCP 294 HSP 3 Score: 75.8702 bits (185), Expect = 3.470e-13 Identity = 65/252 (25.79%), Postives = 99/252 (39.29%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTG--------NILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLC------LQNCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTGESS 1868 V+ ITG L I + + + NL I + S + L + + L + L+ I G + D+ LCY T+NWT ++++N+ C+ C + GCWGPG C +CR F C++ C G ++ + + IC C C L C GP P NC C +FK+ CV+ C KY ++ C CH C + C G +S Sbjct: 395 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDG---------EFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQG------CNGPTS 630 HSP 4 Score: 59.6918 bits (143), Expect = 3.049e-8 Identity = 94/411 (22.87%), Postives = 151/411 (36.74%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFL--QNLKEIRHLLTQSASAALNIM-------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQG-----------CWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPF 2234 A+ K + + E V+G T+ ++ L L +++ +TG +++ L +L +NL+ IR AL I + L+ LGL+ L I G V + LCYADT++W +I++N P N S S G CWGP + C C RC Y + CH C C+GP+ T+C C F ++ CV C + F +N T + +E++ N G ++C K K F C R +K+++ E I +C+PC + C + C+G +G Q + N+ + +C NGN + T DP+ Sbjct: 48 ALRKYYENCEVVMGNLEITSIEHNRDL---------SFLRSIREVTGYVLV-----ALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQ-DIVRNPW------PSNMTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRC-------------------YGPYVSDCCHRECAGGCSGPKDTDCF-ACMNFNDSGACVTQCPQT-FVYNPTTFQ-----LEHNFNAKYTYG----------AFCVK---KCPHNFVVDSSSCVRACPSSKMEVEE-------NGIKMCKPCTDICPKA------------CDGIGTGSLMSAQTVDSS-NIDKFINCTKINGNLIFLVTGIHGDPY 378 HSP 5 Score: 58.151 bits (139), Expect = 8.061e-8 Identity = 34/84 (40.48%), Postives = 40/84 (47.62%), Query Frame = 3 Query: 1485 CDSKCDSQ-----GCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCI 1721 CDS+C+ C GPG C C F+ NCV++C D G S I KY D D C CHP C Q C GP +CI Sbjct: 555 CDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPD--GLQGANSFIFKYADQ--DRECHPCHPNCTQGCNGPTSHDCI 634
BLAST of epidermal growth factor receptor 2 vs. Ensembl Mouse
Match: Erbb4 (erb-b2 receptor tyrosine kinase 4 [Source:MGI Symbol;Acc:MGI:104771]) HSP 1 Score: 248.825 bits (634), Expect = 1.241e-66 Identity = 136/376 (36.17%), Postives = 214/376 (56.91%), Query Frame = 3 Query: 2373 WLSYQENPKFISKWSLIILSVIT--VFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 W + P+ ++ LI VI L+ F YV + + KK + + + + EP L T PN +L ++ T+L K +G+GAFG VY+G+W P + ++ + VA+K++ E M+EA +MAS+ H H +RL+G+CL + L+T + G L Y+ +HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ ++ITDFGLA ++ E ++ E GG++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + S + P YL I D ++ Sbjct: 638 WTGHSTLPQH-ARTPLIAAGVIGGLFILVIMALTFAVYVRRKSIKKKRALRRFLETELVEP-----LTPSGTAPNQAQLRILKETELK---RVKVLGSGAFGTVYKGIWVPEGETVK------IPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLL---EGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFSRMARDPQRYLVIQGDDRMK 994 HSP 2 Score: 109.768 bits (273), Expect = 1.646e-23 Identity = 81/258 (31.40%), Postives = 122/258 (47.29%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEEN--SQYAIFPKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENP--KKQKLITYNKYME-HQCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNF--KLRVGYMCANSCP 904 NC V GNL I ++ + + DL FL SI EVTG + + N + + L NL++IRG L ++ ++++++ + N Q L I N VY ++KFL +I W+++ NP L++ N +CH C CW + NHCQ ++ V E+ D CY G C +C GGC+GPK++DC C + + CV CP F+Y+ +L NF K G C CP Sbjct: 55 NCEVVMGNLEITSI---EHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRG-TKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVD---QNKFLCYADTIHWQDIVRNPWPSNMTLVSTNGSSGCGRCHKSCTGR----CWGPTENHCQTLTRTVCAEQCDG--RCY-----GPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCP 294 HSP 3 Score: 75.8702 bits (185), Expect = 3.575e-13 Identity = 65/252 (25.79%), Postives = 99/252 (39.29%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTG--------NILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLC------LQNCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTGESS 1868 V+ ITG L I + + + NL I + S + L + + L + L+ I G + D+ LCY T+NWT ++++N+ C+ C + GCWGPG C +CR F C++ C G ++ + + IC C C L C GP P NC C +FK+ CV+ C KY ++ C CH C + C G +S Sbjct: 395 VREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRRAENCTAEGMVCNHLCSNDGCWGPGPDQCLSCRRFSRGKICIESCNLYDG---------EFREFENGSICVECDSQCEKMEDGLLTCHGPGPDNCT-KCSHFKDGPNCVEKCPDGLQGANSFIFKYADQDRECHPCHPNCTQG------CNGPTS 630 HSP 4 Score: 59.6918 bits (143), Expect = 3.067e-8 Identity = 94/411 (22.87%), Postives = 151/411 (36.74%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFL--QNLKEIRHLLTQSASAALNIM-------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQG-----------CWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPF 2234 A+ K + + E V+G T+ ++ L L +++ +TG +++ L +L +NL+ IR AL I + L+ LGL+ L I G V + LCYADT++W +I++N P N S S G CWGP + C C RC Y + CH C C+GP+ T+C C F ++ CV C + F +N T + +E++ N G ++C K K F C R +K+++ E I +C+PC + C + C+G +G Q + N+ + +C NGN + T DP+ Sbjct: 48 ALRKYYENCEVVMGNLEITSIEHNRDL---------SFLRSIREVTGYVLV-----ALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQ-DIVRNPW------PSNMTLVSTNGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRC-------------------YGPYVSDCCHRECAGGCSGPKDTDCF-ACMNFNDSGACVTQCPQT-FVYNPTTFQ-----LEHNFNAKYTYG----------AFCVK---KCPHNFVVDSSSCVRACPSSKMEVEE-------NGIKMCKPCTDICPKA------------CDGIGTGSLMSAQTVDSS-NIDKFINCTKINGNLIFLVTGIHGDPY 378 HSP 5 Score: 58.151 bits (139), Expect = 9.126e-8 Identity = 34/84 (40.48%), Postives = 40/84 (47.62%), Query Frame = 3 Query: 1485 CDSKCDSQ-----GCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCI 1721 CDS+C+ C GPG C C F+ NCV++C D G S I KY D D C CHP C Q C GP +CI Sbjct: 555 CDSQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPD--GLQGANSFIFKYADQ--DRECHPCHPNCTQGCNGPTSHDCI 634
BLAST of epidermal growth factor receptor 2 vs. Ensembl Mouse
Match: Erbb3 (erb-b2 receptor tyrosine kinase 3 [Source:MGI Symbol;Acc:MGI:95411]) HSP 1 Score: 221.09 bits (562), Expect = 6.948e-58 Identity = 125/369 (33.88%), Postives = 212/369 (57.45%), Query Frame = 3 Query: 2400 FISKWSLII---LSVITVFLI-SSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLL--LIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVI--RANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDS 3482 +SK L+I + + +FLI ++++R N++ +YL+ S ++ N++L + T+L K +G+G FG V++G+W P + ++ + V +KVI ++ R Q + + + S+ H H +RL+G+C + L+T ++ LGSL ++R+H+ TL + LL+WG QIA GM YLE ++HRDLA RNV+L +Q+ DFG+A ++ D+K +++ S + PI+W+ALE++ G Y+H++DVWS+G+T+WE+ T+G PY L + EI L +G RLAQP+IC++D+Y +M +CW + N RP+F+ L + + + P YL I S Sbjct: 636 LMSKPHLVIAVTVGLTVIFLILGGSFLYWRGRRIQNKRAMRRYLERGES----------IEPLDPSEKANKVLARIFKETELR---KLKVLGSGVFGTVHKGIWIPEGESIK------IPVCIKVIEDKSGRQ-SFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQ-LVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLL--PPDDK-QLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRAS 980 HSP 2 Score: 97.4413 bits (241), Expect = 8.002e-20 Identity = 72/253 (28.46%), Postives = 114/253 (45.06%), Query Frame = 2 Query: 164 CTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAI----FPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 C V GNL I + DL FL I EVTG + + N + LPNL+V+RG + + ++++ L NS +A+ F +L I VY + K + +I W ++ P + ++ N CH C CW CQ +K + N C+ G C ++C GGC+GP+++DC C+ + + CV CP +Y++ +L NP+ K + G +C SCP Sbjct: 56 CEVVMGNLEIVLT---GHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQ---VYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHM-DTIDWRDIVRVPDAEIVVKNNGGNCPPCHEVCKGR----CWGPGPEDCQILTKTICAPQCNGR-CF-----GPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCP 291 HSP 3 Score: 79.337 bits (194), Expect = 2.762e-14 Identity = 72/262 (27.48%), Postives = 104/262 (39.69%), Query Frame = 3 Query: 1185 NVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIM-HTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKP----------CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRC---EDEPGFYTNTSAIKKYTDNYDDGICQRCHPLC-----LQNCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPL--CTGESSIL 1874 V+ ITG L I + N + NL I + +L IM + ++ LG R L+ I G+ + + LCY +LNWT +L+ + + N+P CD C S GCWGPG C +CR + CV C + EP + + + C CHP C C G C C +F++ CV +C KY C CHE C + K L C G++ +L Sbjct: 389 TVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWT-RLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVH------------EAHCFSCHPECQPMEGTSTCNGSGSDAC-ARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVL 636 HSP 4 Score: 53.5286 bits (127), Expect = 2.150e-6 Identity = 52/205 (25.37%), Postives = 79/205 (38.54%), Query Frame = 3 Query: 1179 LGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNW--------TGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNC 1769 L N++ + G + DG + L + N H L Q L F L ++ + G + + LC+ DT++W ++KNN + PPC++ C +C WGPG C C RC F N + Q CH C C+GP+ T+C CR+F ++ CV C Sbjct: 99 LPNLRVVRGTQVYDGKFAIFVMLNYNTNSS---HALRQ------------LRFTQLTEI--LLGGVYIEKNDKLCHMDTIDWRDIVRVPDAEIVVKNNGGN--CPPCHEVCKGRC-----WGPGPEDCQILTKTICAPQCNGRC-----FGPNPN--------------QCCHDECAGGCSGPQDTDCF-ACRHFNDSGACVPRC 259
BLAST of epidermal growth factor receptor 2 vs. UniProt/SwissProt
Match: sp|P24348|LET23_CAEEL (Receptor tyrosine-protein kinase let-23 OS=Caenorhabditis elegans OX=6239 GN=let-23 PE=1 SV=3) HSP 1 Score: 332.028 bits (850), Expect = 2.869e-110 Identity = 276/985 (28.02%), Postives = 439/985 (44.57%), Query Frame = 3 Query: 906 EVDACIYSCNSLHFYRVDN---KCIRCQNSS---VCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIE----HVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH-TDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNI------------LKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRY-------FKENDECVKNCSRKYFSFNK-TCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRH---------YYLNKIDISEVMKRQKSKEIGICQPCLEPCLECS--GNYTIYPTCEKCNGYW----SGDRCVKQCFPIALNLP--RNASCPYCNGNCVERCTVTPNDPFQCGSC-NFKRLYLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND------SCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFV---GDYQDDIEGEPSLKRQSSGFSWSS 3683 E D C+ C+ H Y +C +C++SS +C ++T LKN E H+I E FT + K L V+ ++ + I N +L FL+NL+ I + AL I DLE L L L+ I G + + LCY ++W+ I + N+ + + CD C+ +GCWG C C+ +++V CV++C D GF N +++K C+RC P C + C G +C+ CR+ F ECV +C +F K C KCH TC +N CTG S LG GGC C + ++ +C + + YY++ D V++ C+ C C CS G + C + + S C+ QC + +P N C C+ C + C C NF D CVSECP+ + + + L Y + +II SV+ F + ++I Y K +K I + P+ I + PNM+R+ LIP+++L ++ K +G GAFG V+ G++ P +++ + VA+KV + +++ E++EEA M + H + L++IG C+ + ++T + LG+L +L+ HK L +R + + QIA GM YLE + ++HRDLATRNVL+ ++ITDFGL+ I++ D+ I I G+V I+WLA+E Y+H +DVW+FG+T WEI T+G+ PY + I ++L GNRL+QP CS DLYQ + RCW + RP FE L F + P +L N S + ++ R + + D Q+Y ++ S +++TF GD + ++ S + ++ F + S Sbjct: 333 ENDVCVRHCSDGHHYDATKDVRECEKCRSSSCPKICTVDG---------------HLTNETLKNLEGCEQIDGHLIIEHAFTYEQL-------------KVLETVKIVSEYITIVQQNFY--DLKFLKNLQIIEGRKLHNVRWALAIYQCDDLEELSLNSLKLIKTGAVLIMKNHRLCYVSKIDWSSIITSKGKDNKPSLAIAENRDSKLCETEQRVCDKNCNKRGCWGKEPEDCLECKTWKSVGTCVEKC-DTKGFLRNQTSMK----------CERCSPEC-ETCNGLGELDCLT-CRHKTLYNSDFGNRMECVHDCPVSHFPTQKNVCEKCHPTCYDNG-----CTGPDSNLGYGGCKQCKYAVKYENDTIFCLQSSGMNNVCVENDLPNYYISTYDTEGVIETH-------CEKCSISCKTCSSAGRNVVQNKCVCKHVEYQPNPSERICMDQCPVNSFMVPDTNNTVCKKCHHECDQNYHCANGQSTGCQKCKNFTVFKGDI--AQCVSECPKNLPFSNP----------ANGECLDYDIASRQRKTRMVIIGSVLFGFAVMFLFILLVYWRCQRIGKKLK----IAEMVDMPELTPI--DASVRPNMSRICLIPSSELQTKLDKK-LGAGAFGTVFAGIYYP-----KRAKNVKIPVAIKVFQTDQS-QTDEMLEEATNMFRLRHDNLLKIIGFCMHDDGLKIVTIYRPLGNLQNFLKLHKENLGAREQVLYCYQIASGMQYLEKQRVVHRDLATRNVLVKKFNHVEITDFGLSKILKHDADS---ITIKSGKVAIKWLAIEIFSKHCYTHASDVWAFGVTCWEIITFGQSPYQGMSTDSIHNFLKDGNRLSQPPNCSQDLYQELLRCWMADPKSRPGFEILYERFKEFCKVPQLFLENSNKISESDLSAEERFQTERIREMFDGNIDPQMYFDQGSLPSMPSSPTSMATFTIPHGDLMNRMQSVNSSRYKTEPFDYGS 1234 HSP 2 Score: 92.0485 bits (227), Expect = 2.869e-110 Identity = 77/271 (28.41%), Postives = 116/271 (42.80%), Query Frame = 2 Query: 152 GNHNCTHVEGNLVIQ-------NVWPDQESGDL---GFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYME--------HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 GN T +E N + + V P E L F ++ E+ G + + +I+ I P L+VI G + ++YI D+ + + +LRVI N SV + K ++ I W+EL +P QK+ T N + +CH C ND CW S N CQ+ + V K + C++ N CD C GGC G +C C KY C+E CP I++ +L NP+ + + G C CP Sbjct: 71 GNLEITWIEANEIKKWRESTNSTVDPKNEDSPLKSINFFDNLEEIRGSLIIYRANIQKISFPRLRVIYGDEVF----HDNALYIHKNDKVHE--VVMRELRVIRNGSVTIQDNPKMCYIGDKIDWKELLYDPDVQKVETTNSHQHCYQNGKSMAKCHESC--ND--KCWGSGDNDCQRVYRSVCPK--SCSQCFYS--NSTSSYECCDSACLGGCTGHGPKNCIACSKYELDGICIETCPSRKIFNHKTGRLVFNPDGRYQNGNHCVKECP 327
BLAST of epidermal growth factor receptor 2 vs. UniProt/SwissProt
Match: sp|P0CY46|EGFR_APIME (Epidermal growth factor receptor OS=Apis mellifera OX=7460 GN=Egfr PE=2 SV=1) HSP 1 Score: 380.948 bits (977), Expect = 3.481e-110 Identity = 251/827 (30.35%), Postives = 409/827 (49.46%), Query Frame = 3 Query: 1074 KNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWT--------GNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCY--KDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKS------CVSECPQTHKYKHKDGNL-TDIICMTRSQWLSYQE-NPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYS-NIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDI-QEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 ++F +HV F F + ++K P + ++ ITG L I G + KNL++ +NL+ I A+L ++ T L GL L++I+ G + ++ LCYA ++NWT ++L NN+ + CD +C +GCWGPG C +C+ F +C+ C PG Y D+ C+ CH C +C GP +C C++ ++ CV C ++ N C CH C+ C G + +G GC C K I C K+ CP YY + E + +C+ C C +C+G C++C Y G++C +C P N C C C R P P QC C ++Y+D C C T +Y HK N ++ C + L E P ++ ++ L+ + +++++ ++F V ++ +VK A+ + +EP L+ PN+ +L +I ++ +G GAFG VY+GVW P ++++ + VA+KV+ + +E ++EA +MASV H + L+L+ +C+ +M L+T + LG L ++R+ K + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ ++ITDFGLA ++ + N+ + +GG++PI+WLALE + + +++HK+DVW+FG+T+WE+ TYG RPY+ + R + L +G RL QP IC++D+Y +M +CW +A RPSF+ L + + P YL I D +R Sbjct: 213 QSFQGFQHVYRNFSF-GKRYEK-----MHPDKLEVFSTLKEITGFLNIQGDHKDFKNLSYFRNLEVIGGRTLTEYFASLYVVKTSLVSFGLSSLKKIYSGSIAILENKNLCYAQSINWTRIKKSSEHESLLSNNRNESECIKDGLVCDEQCSDEGCWGPGPAQCLSCKNFILGNDCLQDCT-APGIY-----------QADEKTCKVCHEECDGSCIGPNTDHC-KKCKHARDGPFCVPECPASKYNDNGVCKSCHGNCVGG------CEGPENNIGPNGCHSCDKAILNDHVPEGCLQKKESCPDGYYYEWVSPLEQGPLKPLASKAVCRKCHSRCKKCTGYGFHEHVCQECTKYKRGEQCEDEC-PADYFADANKLCIPCFSEC--RGCFGPG-PNQCYKCRNYKIYIDEDTDGNTTSFNCTETC--TPEYPHKIFNPDSEPYCSLETAGLIENELQPAILAGVAVFALAFL---VVAAIIMYFWRVRAKAKENTVKMTMALTGLDDNEP-----LRPTGVKPNLAKLRIIKEEEMR---KGGILGYGAFGNVYKGVWVPEGENVK------IPVAIKVLHDGTGANTSKEFLDEAYIMASVEHPNLLQLLAVCMTSQM-MLVTQLMPLGCLLDFVRRFKDKIGSKALLNWCTQIARGMAYLEERRLVHRDLAARNVLVQTPNCVKITDFGLAKLL---DINEEQYKAAGGKMPIKWLALECIQHRVFTHKSDVWAFGVTIWEVLTYGGRPYENVPARNVPELLEKGERLPQPAICTIDVYMIMIKCWMLDAESRPSFKELAEDFAKMSRDPGRYLAIKGDKYMR 987 HSP 2 Score: 64.6994 bits (156), Expect = 5.751e-9 Identity = 42/143 (29.37%), Postives = 58/143 (40.56%), Query Frame = 2 Query: 482 QSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNT--KLNPNFKLRVGYMCANSCP 904 ++I WEE+ P YN + + C ++ CW +CQK SK + C+ G C C GGC GPK SDC CK + + C + CPP Y+ + NP+ K G C CP Sbjct: 11 RTINWEEIITGPSAMYSYVYNFTSPERACTPCDKSCEQGCWGEGPENCQKYSK-----TNCSPQCWQGRCFGPNPRECCHLFCAGGCTGPKQSDCIACKNFFDDGVCTQECPPMQKYNPTTYSWEPNPDGKYAYGATCVRRCP 148
BLAST of epidermal growth factor receptor 2 vs. UniProt/SwissProt
Match: sp|P04412|EGFR_DROME (Epidermal growth factor receptor OS=Drosophila melanogaster OX=7227 GN=Egfr PE=1 SV=3) HSP 1 Score: 338.576 bits (867), Expect = 8.011e-95 Identity = 245/849 (28.86%), Postives = 403/849 (47.47%), Query Frame = 3 Query: 1044 DVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITL-PMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIR-HLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTG-------NILKNNQFDPIYPPCNKP---CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRD---EKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYP-TCEKCNGYWSGDRCVKQCFPIALNLPRNASC----PYCNGNCVERCTVTPNDPFQCGSC-NFKRL-------YLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVIT-VFLISSVYIF--FRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVK-VIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 D F I N ++ F ++ I L P + V+ ITG L I+G++ +NL++ +NL+ I L +S AAL I+ + L L +R L++I G + + LCY + W + N C K C +C+ GCWG G+ C C+ F C+ C G+ +N +D+ C+ CHP C + C G +C C + ++ CV C + ++ C +CH TC CTG +G+G C+ C+ I D ++ D CP Y+ + E + +C+ C C C+ NY + C KC Y ++C +C C P CNG CT D C SC NFK Y+++ +C S+CP ++ + C S + K + + ++ +IT L+ ++ I Y+ + QK + +K + DS L+ N+ +L ++ +L +G GAFG VY+GVW P ++++ + VA+K ++++ +E + EA +MAS H + L+L+ +C+ +M LIT + LG L Y+R ++ + S+ LL+W QIA GM+YLE + ++HRDLA RNVL+ +++ITDFGLA ++ + NE +GG++PI+WLALE + N +++ K+DVW+FG+T+WE+ T+G+RP++ + ++I + G +L QPEICS+D+Y + CW+ +A RP+F+ L + + F + P YL IP D R Sbjct: 415 DSFRNCTVIDGNIRILDQTFSGFQDVYANYTMGPRYIPLDPERREVFSTVKEITGYLNIEGTHPQFRNLSYFRNLETIHGRQLMESMFAALAIVKSSLYSLEMRNLKQISSGSVVIQHNRDLCYVSNIRWPAIQKEPEQKVWVNENLRADL--CEKNGTICSDQCNEDGCWGAGTDQCLTCKNFNFNGTCIADC----GYISNAY-------KFDNRTCKICHPEC-RTCNGAGADHC-QECVHVRDGQHCVSECPKNKYNDRGVCRECHATCDG-------CTGPKDTIGIGACTTCNLAIINNDATVKRCLLKDDKCPDGYFWEYVHPQEQGSLKPLAGRAVCRKCHPLCELCT-NYGYHEQVCSKCTHYKRREQCETECPADHYTDEEQRECFQRHPECNG-----CTGPGAD--DCKSCRNFKLFDANETGPYVNSTMFNCTSKCPLEMRHVNYQYTAIGPYCAA-----SPPRSSKITANLDVNMIFIITGAVLVPTICILCVVTYICRQKQKAKKETVKMTMALSGCEDSEP-LRPSNIGANLCKLRIVKDAELR---KGGVLGMGAFGRVYKGVWVPEGENVK------IPVAIKELLKSTGAESSEEFLREAYIMASEEHVNLLKLLAVCMSSQM-MLITQLMPLGCLLDYVRNNRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKITDFGLAKLLS---SDSNEYKAAGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHENIPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQLTTVFAEFARDPGRYLAIPGDKFTR 1214 HSP 2 Score: 104.76 bits (260), Expect = 3.988e-21 Identity = 78/257 (30.35%), Postives = 113/257 (43.97%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQN--SLALEKSEVSVYIDLLDEENSQYAI-FPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL---ITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCPG 907 NCT+V+GNL + W E+ DL FL +I EVTG I + + +K ++ P L++IRG+ SL++E+ + ++++ + Y + P LR + N V F + ++I+W E+ N T + +CH C CW +CQK SK CY G C C GGC GP DC CK + + E CPP Y+ L NP K G C CPG Sbjct: 128 NCTYVDGNLKL--TWLPNENLDLSFLDNIREVTGYILISHVDVKKVVFPKLQIIRGRTLFSLSVEEEKYALFVTY----SKMYTLEIPDLRDVLNGQVGFHNNYNLCHM-RTIQWSEIVSNGTDAYYNYDFTAPERECPKCHESCTHG----CWGEGPKNCQKFSKLTCSPQCAGGRCY-----GPKPRECCHLFCAGGCTGPTQKDCIACKNFFDEAVSKEECPPMRKYNPTTYVLETNPEGKYAYGATCVKECPG 368
BLAST of epidermal growth factor receptor 2 vs. UniProt/SwissProt
Match: sp|P11273|ERBB_AVIEU (Tyrosine-protein kinase transforming protein erbB OS=Avian erythroblastosis virus (strain ts167) OX=103898 GN=V-ERBB PE=3 SV=1) HSP 1 Score: 248.825 bits (634), Expect = 5.329e-70 Identity = 141/353 (39.94%), Postives = 213/353 (60.34%), Query Frame = 3 Query: 2424 ILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 +L ++ V L +Y+ R+ I +K++++ L + E + L PN L ++ T+ K +G GAFG VY+G+W P + ++ ++ VA+K +R A +EI++EA VMASV + H RL+GICL + LIT + G L Y+R+HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ + ++ITDFGLA Q D K E GG+VPI+W+ALE++L+ IY+H++DVWS+G+T+WE+ T+G +PYD + EI+S L +G RL QP IC++D+Y +M +CW +A+ RP F L++ S + P YL I D Sbjct: 74 LLCLVVVGLGIGLYLRRRH---IVRKRTLRRL------LQERELVEPLTPSGEAPNQAHLRILKETEFK---KVKVLGFGAFGTVYKGLWIP------EGEKVTIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEERHMVHRDLAARNVLVKTPQHVKITDFGLAK--QLGADEK-EYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCWMSDADSRPKFRELIAEFSKMARDPPRYLVIQGD 404
BLAST of epidermal growth factor receptor 2 vs. UniProt/SwissProt
Match: sp|P00535|ERBB_AVIER (Tyrosine-protein kinase transforming protein erbB OS=Avian erythroblastosis virus (strain ES4) OX=79685 GN=V-ERBB PE=3 SV=1) HSP 1 Score: 250.366 bits (638), Expect = 7.795e-70 Identity = 138/353 (39.09%), Postives = 213/353 (60.34%), Query Frame = 3 Query: 2424 ILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 +L ++ V L +Y+ R+ I +K++++ L + E + L PN L ++ T+ K +G+GAFG +Y+G+W P + ++ + VA+K +R A +EI++EA VMASV + H RL+GICL + LIT + G L Y+R+HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ + ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ IY+H++DVWS+G+T+WE+ T+G +PYD + EI+S L +G RL QP IC++D+Y +M +CW +A+ RP F L++ S + P YL I D Sbjct: 74 LLCLVVVGLGIGLYLRRRH---IVRKRTLRRL------LQERELVEPLTPSGEAPNQAHLRILKETEFK---KVKVLGSGAFGTIYKGLWIPEGEKVK------IPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ-LITQLMPYGCLLDYIREHKDNIGSQYLLNWCVQIAKGMNYLEERRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGADE---KEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSVLEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIAEFSKMARDPPRYLVIQGD 404
BLAST of epidermal growth factor receptor 2 vs. TrEMBL
Match: A0A1B1ACY2 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 1998.79 bits (5177), Expect = 0.000e+0 Identity = 982/985 (99.70%), Postives = 983/985 (99.80%), Query Frame = 3 Query: 900 VQEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKS--CVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFVGDYQDDIEGEPSLKRQSSGFSWSSKQTRSSQEIDKRLFYFRQHSAVSEDLEENDNFCRSDEQEESDSEYLEPKKIENFK 3848 +QEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAKKEFNINKIINEENEDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKS CVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFVGDYQDDIEGEPSLKRQSSGFSWSSKQTRSSQEIDKRLFYFRQHSAVSEDLEENDNFCRSDEQEESDSEYLEPKKIENFK Sbjct: 312 LQEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAKKEFNINKIINEENEDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKSFQCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFVGDYQDDIEGEPSLKRQSSGFSWSSKQTRSSQEIDKRLFYFRQHSAVSEDLEENDNFCRSDEQEESDSEYLEPKKIENFK 1296 HSP 2 Score: 583.563 bits (1503), Expect = 0.000e+0 Identity = 294/308 (95.45%), Postives = 294/308 (95.45%), Query Frame = 2 Query: 23 MGFVCNXXXXXXXXESSLAIRQFDEEYPGVTICESSMTSG--------------ELGGNHNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGYMCANSCP 904 MGFVCNIIVVIILLESSLAIRQFDEEYPGVTICESSMTSG ELGGNHNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGYMCANSCP Sbjct: 1 MGFVCNIIVVIILLESSLAIRQFDEEYPGVTICESSMTSGFQYFMPHSLMFLKGELGGNHNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGYMCANSCP 308
BLAST of epidermal growth factor receptor 2 vs. TrEMBL
Match: F6KBQ4 (Epidermal growth factor receptor 2 (Fragment) OS=Schmidtea mediterranea OX=79327 GN=egfr-2 PE=2 SV=1) HSP 1 Score: 1548.49 bits (4008), Expect = 0.000e+0 Identity = 750/757 (99.08%), Postives = 751/757 (99.21%), Query Frame = 3 Query: 1584 CEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKS--CVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFVGDYQDDIEGEPSLKRQSSGFSWSSKQTRSSQEIDKRLFYFRQHSAVSEDLEENDNFCRSDEQEESDSEYLEPKKIENFK 3848 CEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYL+KIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKS CVSECPQTHKY HKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLI TFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNV LNDLEIIQITDFGLAHIVQC EDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFVGDYQDDIEGEPSLKRQSSGFSWSSKQTRSSQEIDKRLFYFRQHSAVSEDLEENDNFCRSDEQEESDSEYLEPKKIENFK Sbjct: 1 CEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLDKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKSFQCVSECPQTHKYXHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLIXTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVXLNDLEIIQITDFGLAHIVQCPEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFVGDYQDDIEGEPSLKRQSSGFSWSSKQTRSSQEIDKRLFYFRQHSAVSEDLEENDNFCRSDEQEESDSEYLEPKKIENFK 757
BLAST of epidermal growth factor receptor 2 vs. TrEMBL
Match: A0A1B1ACX9 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 642.499 bits (1656), Expect = 0.000e+0 Identity = 367/922 (39.80%), Postives = 532/922 (57.70%), Query Frame = 3 Query: 885 CARIRVQEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAXXXXXXXXXXXXXXXDVFY--------MTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIR-HLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNK------TCIKCHETCMENDK---NQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQC---FPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDN-HNK-SCVSECPQTHKY-KHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSV---ITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKT-IPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRL----LSQISYDFQVYP 3554 C + + C+Y C+ ++ N+CI C N + K+ N D FY + L T+ ++G+ SF+K G+T+PMLY HL NV+ I G + + NLTFL NL+EIR + + + ++A+NI +EFLGL+KL++++GK + + G CY D + W I +N+ + CNK CD C Q CWGPG+ MCY+C ++A +CV +C D PG++ + + K CQ CHPLC QNCTGP P NC G CRY E + CVKNCS +F TC CH +C + CTG S+ILG GGCS C KLI + ++ C+K CP+ +Y + I+ + + C+PC C CSG+ C +C GY+ ++CVK+C + + L CP C+ C C + ND C C +L++D+ NK SCV+ CP + +++DG D IC+ + ++ ++ K IILS VF+I ++FR+ + NQ + + +KA+YSN EPD + + ++ T PNM R+ +IP +DL+F+ ++KP+G+GAFG VYRG WK +D + +L+V +KVI + E +EEAK+MASV H+HCL LIG+CL E PCL++T+ + GSLDKYL+++ + S ++L W +QIADGM YL RGIIHRDLA RNVL+ND + IQITDFGLA +V T+D+ IVI G+VPIRWLA+ETLL+ YS TDVW++G+TLWEIFTY +RPY+EL EI S+L QGNRL QPEI ++++Y +M +CW ++ + RPSF L+ST F Q P +L +P++ + KD+ + L+QIS D P Sbjct: 310 CPASLLDQNKICVYECDFDAHQKIGNRCIECPNGN--CNSSTAGYKLCNIATIDKFYPKNNRKYSLNKQTLMQLTNCTLILGDLDIDDISFNK--NGVTVPMLYHHLKNVREIIGLFSLVTFQTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFLGLKKLKKVYGKISIGGTNGTCYLDRIPWE-EISPDNR---VKFSCNKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIK-------CQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLA-NDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDG---DFICLKFEETINSKQR-----KTIFIILSGCFGFLVFIIGFCVLYFRW--RANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQD---NKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDS---IVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRP 1198 HSP 2 Score: 137.502 bits (345), Expect = 0.000e+0 Identity = 100/310 (32.26%), Postives = 148/310 (47.74%), Query Frame = 2 Query: 89 FDEEYPGVTICESSMTSGE--------------LGGNHNCTHVEGNLVIQNV--WPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQN--------SLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL----ITYNKYMEHQCHSDC---LRND---FPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLR--VGYMCANSCPGS 910 F+ +YP IC S G LG CTH+ GNL I ++ + + DL FL SIIE++G + + NN +K I L NLKVIRG ++ SE +++ +D N LR I + +V ++L +++ W ++ ++P QKL +CH++C R D +C+ S N CQKQ+KCVK K +++WC F + GEI C +C GGC+G + DC VC K V + CV C P + G ++ KLR VG +C + CP S Sbjct: 21 FNPDYPNFRICVVSEAHGSFKTPAEAYTYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRN--------LRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTREDGVRSQFCFGPSKNECQKQTKCVKNK--DLKWCKF-TKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFG---MDSKDKLRYTVGGLCTSQCPAS 313
BLAST of epidermal growth factor receptor 2 vs. TrEMBL
Match: A0A1B1ACY5 (Receptor protein-tyrosine kinase OS=Schmidtea mediterranea OX=79327 PE=2 SV=1) HSP 1 Score: 548.895 bits (1413), Expect = 0.000e+0 Identity = 339/897 (37.79%), Postives = 485/897 (54.07%), Query Frame = 3 Query: 885 CARIRVQEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAXXXXXXXXXXXXXXXDV---FYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH------TDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCN---KPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYT--NTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYF---SFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNAS-----------CPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWK-PSNKD--LEKSDRD-SLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C + + E C++ C+ +F N CI+C ++C N + D FY+ A L + + ++G T SF K IT+ MLY++L +Q + G N LKNLTFL+NL R S L H T+LEFLGL+ L+ I G F + LCY +N N L N + Y P N K C C +GCWGPG+ +CY CR + A CV C + GFY N+S + C RCHP CL C GP P CI GC+ +EN CV +CS+ ++ + +K C+ CH C E N +CTG SS+ G+GGC+ C +++ R C Y D ++ + C PC E C +C G CE C G W + C +C PR+ S C C+ +C + C + F C C K++YLD C CP + + DI+C++ + + E K ++++++ + +I V I K ++ LKA YSN+ EP+S+ K PNM RL+++ DLIF +KP+G GAFG VY+G WK P N++ L+K+ D L VA+KVI+ N +I+ +M+EAK+MASV H HCLR IG+CL YE PCLI+ +V+ GSLDK+L ++K+ + S +LSW EQIADGM YL R IIHRDLA RNVL++ LE +QITDFGL+ +++ T+D EI+I G+VPIRWLA+ETL +G YSH+TDVW++G+TLWEIFT+G+ PY++ +I ++++G RL+QP+ICS+D+Y +M CW E+ N RP F+ LM T + + + P YL+I D Sbjct: 313 CPAMMLPENTGCVHKCSEGYFKNKSNHCIKCY-GNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKH--NITVEMLYENLNKLQELEGGFSYFKDN-HLKNLTFLRNLLRFRAAYLHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCY---MNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQK-------CLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSE--YNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGF-TCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRC-------PRDESYGTKIIDSISYCKTCHSSC-KGCYGS--TIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHITVGVVVTMLILVIIVIVTIVVYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKP-PNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKD--KEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAYGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGD 1179 HSP 2 Score: 147.902 bits (372), Expect = 0.000e+0 Identity = 99/297 (33.33%), Postives = 149/297 (50.17%), Query Frame = 2 Query: 89 FDEEYPGVTIC-------ESSMTSGE------LGGNHNCTHVEGNLVIQNVWP-DQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLA---LEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL----ITYNKYMEHQCHSDC-LRNDFP--YCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGYMCANSCPG 907 F+EEYPG IC ES +S E + + NCTH++G++ I + + + +L F SI E+ G + ++ N ++ I NL++IRG NS+ ++K + + + F LR I ++V F + K K+LP SIKW ELF +PK Q L +T + + +C C L +F +CW SAN CQ+Q+ C + C + NGE ++G C++QC GGCNG S C CK +N CVE C + G T N F+ G+ C+ CP Sbjct: 23 FEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYI--NGE-EQGCCNDQCLGGCNGGGASKCTACKNMLNEKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPA 315
BLAST of epidermal growth factor receptor 2 vs. TrEMBL
Match: F6KBQ3 (Receptor protein-tyrosine kinase (Fragment) OS=Schmidtea mediterranea OX=79327 GN=egfr-3 PE=2 SV=1) HSP 1 Score: 535.798 bits (1379), Expect = 4.510e-168 Identity = 293/701 (41.80%), Postives = 419/701 (59.77%), Query Frame = 3 Query: 1521 PGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNK------TCIKCHETCMENDK---NQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQC---FPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDN-HNK-SCVSECPQTHKY-KHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSV---ITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKT-IPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRL----LSQISYDFQVYP 3554 PG+ MCY+C ++A +CV +C + PG++ + + K CQ CHPLC QNCTGP P NC G CRY + + C KNCS +F TC CH +C + CTG S+ILG GGCS C KLI + ++ C+K CP+ +Y + I+ + + C+PC C CSG+ C +C GY+ ++CVK+C + + L CP C+ C C + ND C C +L++D+ NK SCV+ CP + +++DG D IC+ + + ++ K IILS VF+I ++FR+ + NQ + + +KA+YSN EPD + + ++ T PNM R+ +IP +DL+F+ ++KP+G+GAFG VYRG WK +D + +L+V +KVI + E +EEAK+MASV H+HCL LIG+CL E PCL++T+ + GSLDKYL+++ + S ++L W +QIADGM YL RGIIHRDLA RNVL+ND + IQITDFGLA +V T+D+ IVI G+VPIRWLA+ETLL+ YS TDVW++G+TLWEIFTY +RPY+EL EI S L QGNRL QPEI ++++Y +M +CW ++ + RPSF L+ST F Q P +L +P++ + KD+ + L+QIS D P Sbjct: 1 PGNEMCYSCAYYKAGNSCVKQCSNSPGYFASQTEFKTIK-------CQTCHPLCXQNCTGPTPKNCGGQCRYAIKKNTCEKNCSIDFFPVANNVNAPITCQLCHSSCFVBKTLVGTNXACTGPSNILGTGGCSKCEKLIKTNNNQYLCHKGSCPKGFYQSVINQNISHLHKNIVHQSSCEPCHSMCRTCSGSTNEKRMCHQCKGYFLDNKCVKECDNMKNVTIKLEIGDECPQCHKECRNGCLLA-NDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDG---DFICLKFEETFNSKQR-----KTIFIILSGCFGFLVFIIGFCVLYFRW--RANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQD---NKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDS---IVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSLLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRP 677
BLAST of epidermal growth factor receptor 2 vs. Ensembl Cavefish
Match: ENSAMXT00000002946.2 (pep primary_assembly:Astyanax_mexicanus-2.0:12:28119056:28308465:-1 gene:ENSAMXG00000002862.2 transcript:ENSAMXT00000002946.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 255.373 bits (651), Expect = 5.522e-69 Identity = 163/493 (33.06%), Postives = 249/493 (50.51%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERC------------TVTPNDPFQCGSCNFKRLYLDNHNKSCVSECPQTHK------YKHKDGN----LTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYI--FFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 C C Y G CV+ C NL R + NG+ C T P QC C L+L + +CV +CP + +K+ + N C Q+ + + LI VI ++ + F YV + + KK + + + + EP L T PN +L ++ T+L K +GTGAFG VY+G+W P + ++ + VA+K++ E M+EA +MAS+ H H +RL+G+CL + L+T + G L Y+ +HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ I+ITDFGLA ++ E N GG++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + + P YL I D C++ Sbjct: 474 CLSCRFYSRGRTCVRSC-----NLYRGDIREFANGSVCMECDSQCEKAGDKTMTCHGPGPDQCTKC----LHLKD-GPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQGCTGPRIQDCIGMLDRTPLIAAGVIGGMFVAVIVALGFAIYVRRKSIKKKRALRRFLETELVEP-----LTPSGTAPNQAQLRILKETELK---RVKILGTGAFGTVYKGIWVPEGESVK------IPVAIKILNETTGPKANVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVRSPNHIKITDFGLARLLDADEKEYN---ADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELAAEFCRMARDPQRYLVIQGDDCMK 938 HSP 2 Score: 100.523 bits (249), Expect = 8.503e-21 Identity = 77/255 (30.20%), Postives = 115/255 (45.10%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIF--PKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NC V GNL I ++ + + +L FL SI EVTG + + N + L NL++IRG +Y +YA+ L I N VY ++KFL +I W+++ +NP+ + L+ + C C R+ CW + CQ +K V E+ D C+ G C +C GGC+GPK++DC C + + CV CP F+Y+ +L NP K G C CP Sbjct: 29 NCEVVMGNLEITSI---ERNRNLNFLKSIREVTGYVLVALNQFDYLPLENLRIIRG----------TKLY-------EGRYALLGLKNLTEILNGGVYVD---QNKFLCHADTIHWQDILKNPRAELLVVPSNNSGSTCRR-CHRSCNGRCWGHQEDQCQTLTKTVCAEQCDG--RCF-----GPYVSDCCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTTFQLEHNPKAKYTYGAFCVKKCP 252 HSP 3 Score: 71.633 bits (174), Expect = 5.393e-12 Identity = 69/252 (27.38%), Postives = 98/252 (38.89%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTG--------NILKNNQFDPIYPPCNKP---CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLC------LQNCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTG 1859 V+ ITG L I + +L NL I S + L + + L + L+ I G + ++ LCY +T+NWTG ++K+N+ DP C + CD C GCWGPG C +CR + CV C G I+++ + +C C C C GP P C C + K+ CV+ C KY N C CH C + CTG Sbjct: 349 VKEITGFLNIQSWPENMTDLGVFSNLATIGGRSLYSGISLLILKQRWITALQFQSLKEISAGNVYITNNSQLCYYNTVNWTGLFRTGGQRALIKSNK-DPRE--CTQERMVCDKLCSEDGCWGPGPDQCLSCRFYSRGRTCVRSCNLYRG------DIREFANG---SVCMECDSQCEKAGDKTMTCHGPGPDQCT-KCLHLKDGPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQG------CTG 581 HSP 4 Score: 66.2402 bits (160), Expect = 2.271e-10 Identity = 36/85 (42.35%), Postives = 46/85 (54.12%), Query Frame = 3 Query: 1485 CDSKCDSQG-----CWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIG 1724 CDS+C+ G C GPG C C + NCV++C D G TS I KY ++ ++ C CHP C Q CTGPR +CIG Sbjct: 509 CDSQCEKAGDKTMTCHGPGPDQCTKCLHLKDGPNCVEKCPD--GLQGATSFIFKYAESNNE--CHPCHPNCTQGCTGPRIQDCIG 589 HSP 5 Score: 54.299 bits (129), Expect = 1.070e-6 Identity = 63/238 (26.47%), Postives = 94/238 (39.50%), Query Frame = 3 Query: 1167 LYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALN------------IMHTDL-----EFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCN------KPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIK 1808 L K N + + G+L I S +NL FL++++E+ T ALN I T L LGL+ L I G V + LC+ADT++W +ILKN + + + P N + C C+ + CWG C C RC + + CH C C+GP+ T+C C F ++ CV C + F +N T + Sbjct: 23 LRKFYENCEVVMGNLEIT-SIERNRNLNFLKSIREV----TGYVLVALNQFDYLPLENLRIIRGTKLYEGRYALLGLKNLTEILNGGVYVDQNKFLCHADTIHWQ-DILKNPRAELLVVPSNNSGSTCRRCHRSCNGR-CWGHQEDQCQTLTKTVCAEQCDGRC-------------------FGPYVSDCCHRECAGGCSGPKDTDCF-ACTNFNDSGACVTQCPQP-FVYNPTTFQ 232
BLAST of epidermal growth factor receptor 2 vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629]) HSP 1 Score: 254.603 bits (649), Expect = 6.837e-69 Identity = 135/355 (38.03%), Postives = 211/355 (59.44%), Query Frame = 3 Query: 2427 LSVITVFLISSVYIFFRY---VNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 +SVI ++ + F V + +++ +K + + + E + L PN + L ++ T+ K +G+GAFG VY+G+W P +D++ + VA+KV+R A +EI++EA VMASV H H RL+GICL + L++ + G L Y++++K + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ + ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ Y+H++DVWS+G+T+WE+ T+G +PYD + EI L +G RL QP IC++D+Y +M +CW +A RP F L++ S + PT YL I D Sbjct: 587 MSVIAAGVVGGILAFVILSLGVAVLVRRRHIKRKRTLRRLLQERELVEPLTPSGEAPNQSLLRILKETEFK---KIKVLGSGAFGTVYKGLWVPEGEDVK------IPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTSTVQ-LVSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADE---KEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVIQGD 928 HSP 2 Score: 84.7297 bits (208), Expect = 4.690e-16 Identity = 66/249 (26.51%), Postives = 99/249 (39.76%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQF-------DPIY-PPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ-----NCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTG 1859 V+ ITG L++ + +L+ +NL+ IR + +L I + LGLR LR I G + + LCY +W +Q DP N+ CD C +GCWGPG MC++C+ + +CV C G + + C C P C C+ P P C+ C +F++ CV C + KY + C CH+ C + CTG Sbjct: 340 VKEITGSLLVQYWPKNMPSLSPFENLEVIRGRTKHQGTVSLGIGKLPITHLGLRALREISDGDVSISANAKLCYNSPEHWKRLFRSEDQVARPMQNADPATCAALNQTCDEMCTPEGCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECEV---------NMTCLECDPECRPLNGSLTCSKPGPDGCV-ECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQG------CTG 572 HSP 3 Score: 77.0258 bits (188), Expect = 1.199e-13 Identity = 66/250 (26.40%), Postives = 96/250 (38.40%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NCT + NL I DL FL SI EV G + + N I L NL++IRG ++Y L L V++N + N K + + CHSDC CW+ +CQ +K + E C + + G C+ C GC GP+ +DC C+ + + N C + CPP +Y+ +L NP+ K G C +CP Sbjct: 46 NCTVILENLEITYT---SHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLRIIRGH----------TLYDGL------------ALAVLSN-----------------------YNNSKGLRELPLISLTGKMCHSDCYNGS---CWAPGRANCQTFTK-----LTCAEQCSGRCK-GPKPSDCCNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGKYNFGATCVKNCP 238
BLAST of epidermal growth factor receptor 2 vs. Ensembl Cavefish
Match: egfra (epidermal growth factor receptor-like [Source:NCBI gene;Acc:103031629]) HSP 1 Score: 254.988 bits (650), Expect = 8.094e-69 Identity = 135/355 (38.03%), Postives = 211/355 (59.44%), Query Frame = 3 Query: 2427 LSVITVFLISSVYIFFRY---VNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 +SVI ++ + F V + +++ +K + + + E + L PN + L ++ T+ K +G+GAFG VY+G+W P +D++ + VA+KV+R A +EI++EA VMASV H H RL+GICL + L++ + G L Y++++K + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ + ++ITDFGLA ++ E E GG+VPI+W+ALE++L+ Y+H++DVWS+G+T+WE+ T+G +PYD + EI L +G RL QP IC++D+Y +M +CW +A RP F L++ S + PT YL I D Sbjct: 647 MSVIAAGVVGGILAFVILSLGVAVLVRRRHIKRKRTLRRLLQERELVEPLTPSGEAPNQSLLRILKETEFK---KIKVLGSGAFGTVYKGLWVPEGEDVK------IPVAIKVLREATSPKANKEILDEAYVMASVEHPHVCRLLGICLTSTVQ-LVSQLMPYGCLLDYVKENKDNIGSQHLLNWCVQIAKGMNYLEDRHLVHRDLAARNVLVKTPQHVKITDFGLAKLLSADE---KEYHADGGKVPIKWMALESILHRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGVLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIAEFSKMARDPTRYLVIQGD 988 HSP 2 Score: 88.9669 bits (219), Expect = 2.463e-17 Identity = 72/260 (27.69%), Postives = 108/260 (41.54%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSV--YFKTKVKHKFLP-----QSIKWEELFENPKKQKLITYNKYMEH---QCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NCT + NL I DL FL SI EV G + + N I L NL++IRG ++Y L S Y LR + S+ K VK P ++I+W ++ + + + + CHSDC CW+ +CQ +K + E C + + G C+ C GC GP+ +DC C+ + + N C + CPP +Y+ +L NP+ K G C +CP Sbjct: 61 NCTVILENLEITYT---SHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLRIIRGH----------TLYDGLALAVLSNYNNSKGLRELPLISLTEILKGGVKFAHNPYLCNVETIQWADIMSSKDSSQFVKFESTTSKDCKMCHSDCYNGS---CWAPGRANCQTFTK-----LTCAEQCSGRCK-GPKPSDCCNMHCASGCTGPRPTDCLACRDFQDDNTCKDACPPLMLYNPNTHQLAPNPDGKYNFGATCVKNCP 298 HSP 3 Score: 85.1149 bits (209), Expect = 4.106e-16 Identity = 66/249 (26.51%), Postives = 99/249 (39.76%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQF-------DPIY-PPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ-----NCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTG 1859 V+ ITG L++ + +L+ +NL+ IR + +L I + LGLR LR I G + + LCY +W +Q DP N+ CD C +GCWGPG MC++C+ + +CV C G + + C C P C C+ P P C+ C +F++ CV C + KY + C CH+ C + CTG Sbjct: 400 VKEITGSLLVQYWPKNMPSLSPFENLEVIRGRTKHQGTVSLGIGKLPITHLGLRALREISDGDVSISANAKLCYNSPEHWKRLFRSEDQVARPMQNADPATCAALNQTCDEMCTPEGCWGPGPTMCFSCKHYSRKKSCVAFCNLLEGEHRECEV---------NMTCLECDPECRPLNGSLTCSKPGPDGCV-ECAHFRDGPHCVARCPQGIPGEKDTLVWKYPDSMRVCQLCHQNCTQG------CTG 632 HSP 4 Score: 52.7582 bits (125), Expect = 2.680e-6 Identity = 62/245 (25.31%), Postives = 94/245 (38.37%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKH----LGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNN------QFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNC 1769 IL+N +I + E + + +GG L L K L N++ I G + DG + L L+ N K +R L S + L G + +P LC +T+ W +I+ + +F+ K C S C + CW PG C C RC+ K +D C C+ C CTGPRPT+C+ CR F++++ C C Sbjct: 64 VILENL-EITYTSHEHDLSFLKSIEEVGGYVLIGLNKAPRIPLDNLRIIRGHTLYDG--LALAVLSNYNNSKGLRELPLISLTEILK------------------GGVKFAHNPYLCNVETIQW-ADIMSSKDSSQFVKFESTTSKDCKMCHSDCYNGSCWAPGRANCQTFTKLTCAEQCSGRCKG-----------PKPSD------C--CNMHCASGCTGPRPTDCL-ACRDFQDDNTCKDAC 266
BLAST of epidermal growth factor receptor 2 vs. Ensembl Cavefish
Match: ENSAMXT00000013634.2 (receptor tyrosine-protein kinase erbB-4 [Source:NCBI gene;Acc:103038099]) HSP 1 Score: 251.136 bits (640), Expect = 1.308e-67 Identity = 164/488 (33.61%), Postives = 256/488 (52.46%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPRNAS-CPYCNGNCVERC--TVTPNDPF--QCGSCNFKRLYLDNHNKSCVSECPQTHK------YKHKDGN----LTDIICMTRSQWLSYQENPKFISKWSLIILSVI----TVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 C C Y G CVK C + N S C C+G C + TVT + P QC C L+L + +CV +CP + +K+ + N C Q+ + + LI+ I V +I+ + F I +K+ ++ + + + + EP L T PN +L ++ T+L K +GTGAFG VY+G+W P + ++ + VAVK++ E M+EA +MAS+ H H +RL+G+CL + L+T + G L Y+ +HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ I+ITDFGLA ++ + N+ E GG++ I+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + EI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L++ + P YL I D C++ Sbjct: 494 CLSCKFYSRGKTCVKSCNLYNVREFANGSVCVECDGQCEKTGDRTVTCHGPGPDQCTKC----LHLKD-GPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQGCTGPRIQDCIGLLDRTPLIVAGTIGGLFVVVIIALGFAIFARRKSIKKKRCLR--RFLETELVEP-----LTPSGTAPNQAQLRILKETELK---RVKILGTGAFGTVYKGIWVPEGESVK------IPVAVKILSETTGPKASVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLL---DTNEKEYNADGGKMAIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPPCEIPEILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELVAEFCRMARDPQRYLVIQGDDCMK 956 HSP 2 Score: 102.449 bits (254), Expect = 2.070e-21 Identity = 77/257 (29.96%), Postives = 119/257 (46.30%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAI----FPKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NC V GNL I ++ + + +L FL SI EVTG + + N + L NL++IRG L + ++ I L + + + L I N VY ++KFL +I W+++ NP+ + L+ + + C C R+ CW + CQ +K V E+ D C+ G C +C GGC+GPK++DC C + + CV CP F+Y+ + +L NP K G C CP Sbjct: 29 NCEVVMGNLEITSI---ERNRNLNFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTK---LYEGRYALAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVD---QNKFLCHADTIHWQDIVYNPRAELLVVPSNNSGNSCRR-CHRSCNGRCWGHQEDQCQSLTKMVCAEQCDG--RCF-----GPYVSDCCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPKAKYTYGAFCVKKCP 268 HSP 3 Score: 65.855 bits (159), Expect = 3.518e-10 Identity = 63/249 (25.30%), Postives = 94/249 (37.75%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTG--------NILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ------NCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTG 1859 V+ ITG L I + N NL I S + L + + L + L+ I G + ++ LCY +T+NWTG ++K+N+ CD C +GCWG G C +C+ + CV C N ++++ + +C C C + C GP P C C + K+ CV+ C KY N C CH C + CTG Sbjct: 369 VREITGFLNIQSWPENMTNFGVFSNLATIGGRSLYSGISLLILKLRWIISLQFQSLQEISAGNVYITNNSQLCYYNTVNWTGLFRTRGQRAVIKSNKDLRECSQLQMVCDKLCSEEGCWGSGPDQCLSCKFYSRGKTCVKSC--------NLYNVREFANG---SVCVECDGQCEKTGDRTVTCHGPGPDQCT-KCLHLKDGPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQG------CTG 599 HSP 4 Score: 64.6994 bits (156), Expect = 6.416e-10 Identity = 35/85 (41.18%), Postives = 45/85 (52.94%), Query Frame = 3 Query: 1485 CDSKCDSQG-----CWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIG 1724 CD +C+ G C GPG C C + NCV++C D G TS I KY ++ ++ C CHP C Q CTGPR +CIG Sbjct: 527 CDGQCEKTGDRTVTCHGPGPDQCTKCLHLKDGPNCVEKCPD--GLQGATSFIFKYAESNNE--CHPCHPNCTQGCTGPRIQDCIG 607 HSP 5 Score: 56.225 bits (134), Expect = 2.930e-7 Identity = 85/395 (21.52%), Postives = 149/395 (37.72%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFL--QNLKEIRHLLTQSASAALNIM-------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCN------KPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCV 2201 + K + + E V+G T+ ++ L L +++ +TG +++ L +L +NL+ IR AL I + L LGL+ L I G V + LC+ADT++W +I+ N + + + P N + C C+ + CWG C + C RC + + CH C C+GP+ T+C C F ++ CV C + F +N T + +E++ G ++C K K F + C R NK+++ E ++ +C PC + C + C+G +G + Q + N+ + +C NGN + Sbjct: 22 TLRKFYENCEVVMGNLEITSIERNRNL---------NFLKSIREVTGYVLV-----ALNQFDYLPLENLRIIRGTKLYEGRYALAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQNKFLCHADTIHWQ-DIVYNPRAELLVVPSNNSGNSCRRCHRSCNGR-CWGHQEDQCQSLTKMVCAEQCDGRC-------------------FGPYVSDCCHRECAGGCSGPKDTDCF-ACTNFNDSGACVTQCPQP-FVYNPTSFQ-----LEHNPKAKYTYG----------AFCVK---KCPHNFVVDQSSCVRACPSNKMEVEE-------NQVKMCIPCTDICPKV------------CDGIGTGSLQMAQTVDSS-NIHKFVNCTKINGNLI 341
BLAST of epidermal growth factor receptor 2 vs. Ensembl Cavefish
Match: ENSAMXT00000030092.1 (receptor tyrosine-protein kinase erbB-4 [Source:NCBI gene;Acc:103038099]) HSP 1 Score: 250.366 bits (638), Expect = 4.396e-67 Identity = 163/490 (33.27%), Postives = 258/490 (52.65%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPRNAS---CPYCNGNCVERC--TVTPNDPF--QCGSCNFKRLYLDNHNKSCVSECPQTHK------YKHKDGN----LTDIICMTRSQWLSYQENPKFISKWSLIILSVI----TVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 C C Y G CVK C + ++ A+ C C+G C + TVT + P QC C L+L + +CV +CP + +K+ + N C Q+ + + LI+ I V +I+ + F I +K+ ++ + + + + EP L T PN +L ++ T+L K +GTGAFG VY+G+W P + ++ + VAVK++ E M+EA +MAS+ H H +RL+G+CL + L+T + G L Y+ +HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ I+ITDFGLA ++ + N+ E GG++ I+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + EI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L++ + P YL I D C++ Sbjct: 536 CLSCKFYSRGKTCVKSCNLYSGDVREFANGSVCVECDGQCEKTGDRTVTCHGPGPDQCTKC----LHLKD-GPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQGCTGPRIQDCIGLLDRTPLIVAGTIGGLFVVVIIALGFAIFARRKSIKKKRCLR--RFLETELVEP-----LTPSGTAPNQAQLRILKETELK---RVKILGTGAFGTVYKGIWVPEGESVK------IPVAVKILSETTGPKASVEFMDEALIMASMEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLL---DTNEKEYNADGGKMAIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPPCEIPEILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPRFKELVAEFCRMARDPQRYLVIQGDDCMK 1000 HSP 2 Score: 102.064 bits (253), Expect = 3.023e-21 Identity = 77/257 (29.96%), Postives = 119/257 (46.30%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAI----FPKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NC V GNL I ++ + + +L FL SI EVTG + + N + L NL++IRG L + ++ I L + + + L I N VY ++KFL +I W+++ NP+ + L+ + + C C R+ CW + CQ +K V E+ D C+ G C +C GGC+GPK++DC C + + CV CP F+Y+ + +L NP K G C CP Sbjct: 71 NCEVVMGNLEITSI---ERNRNLNFLKSIREVTGYVLVALNQFDYLPLENLRIIRGTK---LYEGRYALAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVD---QNKFLCHADTIHWQDIVYNPRAELLVVPSNNSGNSCRR-CHRSCNGRCWGHQEDQCQSLTKMVCAEQCDG--RCF-----GPYVSDCCHRECAGGCSGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPKAKYTYGAFCVKKCP 310 HSP 3 Score: 65.4698 bits (158), Expect = 4.726e-10 Identity = 35/85 (41.18%), Postives = 45/85 (52.94%), Query Frame = 3 Query: 1485 CDSKCDSQG-----CWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIG 1724 CD +C+ G C GPG C C + NCV++C D G TS I KY ++ ++ C CHP C Q CTGPR +CIG Sbjct: 571 CDGQCEKTGDRTVTCHGPGPDQCTKCLHLKDGPNCVEKCPD--GLQGATSFIFKYAESNNE--CHPCHPNCTQGCTGPRIQDCIG 651 HSP 4 Score: 64.3142 bits (155), Expect = 8.683e-10 Identity = 63/249 (25.30%), Postives = 95/249 (38.15%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTG--------NILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ------NCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMENDKNQPLCTG 1859 V+ ITG L I + N NL I S + L + + L + L+ I G + ++ LCY +T+NWTG ++K+N+ CD C +GCWG G C +C+ + CV C Y+ ++++ + +C C C + C GP P C C + K+ CV+ C KY N C CH C + CTG Sbjct: 411 VREITGFLNIQSWPENMTNFGVFSNLATIGGRSLYSGISLLILKLRWIISLQFQSLQEISAGNVYITNNSQLCYYNTVNWTGLFRTRGQRAVIKSNKDLRECSQLQMVCDKLCSEEGCWGSGPDQCLSCKFYSRGKTCVKSCN----LYSGD--VREFANG---SVCVECDGQCEKTGDRTVTCHGPGPDQCT-KCLHLKDGPNCVEKCPDGLQGATSFIFKYAESNNECHPCHPNCTQG------CTG 643 HSP 5 Score: 55.4546 bits (132), Expect = 4.503e-7 Identity = 85/395 (21.52%), Postives = 149/395 (37.72%), Query Frame = 3 Query: 1065 AILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFL--QNLKEIRHLLTQSASAALNIM-------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCN------KPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCV 2201 + K + + E V+G T+ ++ L L +++ +TG +++ L +L +NL+ IR AL I + L LGL+ L I G V + LC+ADT++W +I+ N + + + P N + C C+ + CWG C + C RC + + CH C C+GP+ T+C C F ++ CV C + F +N T + +E++ G ++C K K F + C R NK+++ E ++ +C PC + C + C+G +G + Q + N+ + +C NGN + Sbjct: 64 TLRKFYENCEVVMGNLEITSIERNRNL---------NFLKSIREVTGYVLV-----ALNQFDYLPLENLRIIRGTKLYEGRYALAIFLNYRRDGYFGLRQLGLKNLTEILNGGVYVDQNKFLCHADTIHWQ-DIVYNPRAELLVVPSNNSGNSCRRCHRSCNGR-CWGHQEDQCQSLTKMVCAEQCDGRC-------------------FGPYVSDCCHRECAGGCSGPKDTDCF-ACTNFNDSGACVTQCPQP-FVYNPTSFQ-----LEHNPKAKYTYG----------AFCVK---KCPHNFVVDQSSCVRACPSNKMEVEE-------NQVKMCIPCTDICPKV------------CDGIGTGSLQMAQTVDSS-NIHKFVNCTKINGNLI 383
BLAST of epidermal growth factor receptor 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003172.1 (pep scaffold:Pmarinus_7.0:GL476855:1052:76454:1 gene:ENSPMAG00000002842.1 transcript:ENSPMAT00000003172.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 253.062 bits (645), Expect = 3.235e-70 Identity = 169/523 (32.31%), Postives = 270/523 (51.63%), Query Frame = 3 Query: 1983 ISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYP----TCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR-PMKKDKHRLLSQIS 3533 I+E R+ ++ +C PC CL + + T + +C +C Y G CV C P+ G E + P+ C C+ +C C K G L D + L +P + + + + L++ V + R I +K++++ + I + EP L PN +L ++ T+L K +G+GAFG V++G+W P +D++ + VA+KV+R A +EI++EA +MASV H H +RL+GICL + L+T + LG L +Y R+HK + S+ LL+W QIA GM YLE + ++HRDLA RNVL+ + ++ITDFGLA ++ + N+ E GG++PI+WLALE++ ++H++DVWS+G+T+WE+ T+G +PY+ + R+I L +G RL QP IC++D+Y +M +CW +A RP F+ L S + P YL I D + P D H L S ++ Sbjct: 400 ITEGPYREHMQD-AVCAPCDPECLPVNDSVTCFGPGSNSCVRCAHYKDGPHCVSAC-PVGAQ-----------GENDEIISKYPDKNNTCQPCH----------PNCSHGC--------KGGGLLDCHLIGP---LFRTGSPVLAVMAVGGLFACVMLLLLAVVCVRRR---NIARKRAMR--RYIEKELVEP-----LTPSGAAPNQAQLRILKETELR---KGKMLGSGAFGTVHKGIWTPEGEDVK------IPVAIKVLREATSPKANKEILDEAYIMASVSHPHLVRLLGICLTPSVQ-LVTQLMPLGCLLEYTREHKEHIGSQLLLNWAVQIAKGMMYLEEQRLVHRDLAARNVLVRTPQHVKITDFGLARLL---DINEIEYHADGGKMPIKWLALESIQYRTFTHQSDVWSYGVTIWELMTFGGKPYEGIPARDIPELLEKGERLPQPPICTIDVYMIMVKCWMIDAESRPRFKELAVEFSKMARDPQRYLVIQGDDRMTLPSPSDSHFLQSLLA 865 HSP 2 Score: 94.7449 bits (234), Expect = 7.257e-20 Identity = 75/284 (26.41%), Postives = 114/284 (40.14%), Query Frame = 3 Query: 1185 NVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHT---DLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKP----------CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ-----NCTGPRPTNCIGGCRYFKENDECVKNCS-----------RKYFSFNKTCIKCHETCMENDKNQPLC----------TGES--SILGLGGCSYCSKLI 1910 +++ ITG L+I + + +NL IR + QS +++ ++ LGL L+ + G + ++ LCY +T+ W + Q ++ NKP CD C GCWGPG C +CR FR +CV+ C G Y ++ D +C C P CL C GP +C+ C ++K+ CV C KY N TC CH C K L TG +++ +GG C L+ Sbjct: 253 SIKEITGHLMIQAWPENMTDFAVFENLTTIRGRVLQSVGRTFSLLVARIPNITALGLASLQEVSAGNVYLKNNERLCYYNTIKWPAVFVSEQQTSYVHD--NKPEADCNADGAVCDLLCSEHGCWGPGPDQCISCRFFRRARSCVESCYITEG---------PYREHMQDAVCAPCDPECLPVNDSVTCFGPGSNSCV-RCAHYKDGPHCVSACPVGAQGENDEIISKYPDKNNTCQPCHPNCSHGCKGGGLLDCHLIGPLFRTGSPVLAVMAVGGLFACVMLL 524 HSP 3 Score: 66.6254 bits (161), Expect = 3.345e-11 Identity = 45/166 (27.11%), Postives = 71/166 (42.77%), Query Frame = 2 Query: 419 LRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSK--CVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 L I + VY K KH ++ W ++ + + N CH C + +CW + +CQK +K C ++ C + +G C QC GC+GP+++ C CK + + CV +CPP IY+ NP+ K G +C CP Sbjct: 1 LSEILHGGVYIKEN-KHLCYHNTVDWWDIVKEGSIVNIDMDNSTTCTSCHKGCHK----HCWGNGMKYCQKCTKLTCARQ-------CDGRC-HGPTPSECCHSQCAAGCDGPRDTHCFACKNFNDSGSCVSHCPPPTIYNPVTFAQGENPDVKYSYGAICVKECP 153 HSP 4 Score: 53.1434 bits (126), Expect = 4.351e-7 Identity = 55/245 (22.45%), Postives = 94/245 (38.37%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVW---------PDQESGDLGFLSSIIEVTGMIFMK---NNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDF----PYCWSSSANHCQKQSKCVKEKVDNIEWCY-----FKMRNGEIDEGFCDEQC-----TGGCNGPKNSDCAVCKKYVNGNHCVEYCP 817 NCT + GN+ P + L SI E+TG + ++ N + NL IRG+ L+ + + + N L+ ++ +VY K + + +IKW +F + ++ + NK E C++D D CW + C + + +E CY ++ + CD +C + C GP ++ C C Y +G HCV CP Sbjct: 217 NCTKINGNIAFLTTGIKGDDYMKIPPLDPDKLNVFRSIKEITGHLMIQAWPENMTDFAVFENLTTIRGR---VLQSVGRTFSLLVARIPNITALGLASLQEVSAGNVYLKNNERLCYY-NTIKWPAVFVSEQQTSYVHDNK-PEADCNADGAVCDLLCSEHGCWGPGPDQC-ISCRFFRRARSCVESCYITEGPYREHMQDAVCAPCDPECLPVNDSVTCFGPGSNSCVRCAHYKDGPHCVSACP 455
BLAST of epidermal growth factor receptor 2 vs. Ensembl Sea Lamprey
Match: EGFR (epidermal growth factor receptor [Source:HGNC Symbol;Acc:HGNC:3236]) HSP 1 Score: 198.364 bits (503), Expect = 5.105e-52 Identity = 141/492 (28.66%), Postives = 239/492 (48.58%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPI---ALNLPRNASCPYCNGNCV---ERCTVTPNDPFQCGSCNFKRLYLDNHNKSCVSECPQ---------THKYKHKDG-------NLTDIICMTRSQWLSYQENPKFISKWSLIILSVIT-----VFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDI-QEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C C + G CV+ C + A C C+ C+ T P C C R CV CP+ +KY +DG N T R + Y N ++K +I V++ L+ +++I+ R+ N + ++ KY++ + +P L PN +L ++ T+L K +G+GAFG VY+G+W P + ++ + VAVKV+R + + ++I++EA +MASV H H +RL+GIC+ L+T + G L +Y+R+H+ + S+ +L+W QIA + ++ ++ DL L+ L A++ Q +D K+ +PI+W+ALE++ ++H++DVWS+G+T+WE+ T+G +PYD + R+I L +G RL QP +C++D+Y +M +CW +A RP F L + S + P+ YL I D Sbjct: 493 CLSCKFHKRGKTCVESCSVLDGDEREFVSGALCIACHAECMLINGSLTCHGPGPDNCTRCRNYR-----EGPHCVGFCPEGVPGESGELIYKYPDEDGVCHPCHYNCTQGEIGERHKGAPYWAN---VNKVPVIAAGVVSGLFAVFLLLLALFIYKRHQNALRKRTLRKYVENERPQLVQP-----LTPSGAQPNQAQLRILKETELK---KGKVLGSGAFGTVYKGIWVPEGESVK------IAVAVKVLRDSASSKANKDILDEAYLMASVDHPHLVRLLGICMSSTTQ-LVTQLMPHGCLLEYVREHRGRVGSQLILNWCVQIAKNASEIQALQMVCDDLVR---LVMSLRTPPRITLASANLFQSIDDAKH---WHDRDMPIKWMALESIQYRKFTHQSDVWSYGVTVWELMTFGGKPYDGISARDIPGLLEKGERLPQPPVCTIDVYMIMVKCWMIDAESRPRFSELATDFSKMARDPSRYLVIQGD 955 HSP 2 Score: 68.1662 bits (165), Expect = 1.062e-11 Identity = 62/246 (25.20%), Postives = 103/246 (41.87%), Query Frame = 3 Query: 1185 NVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDS--PGLCYADTLNWTGNILKNNQFDPIYP-PCNKP------CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCE----DEPGFYTNTSAIKKYTDNYDDGICQRCHPLCL-----QNCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMEND 1835 ++Q +TG L+++ + + L FL +L + Q + ++H L F+ +R + F+V + P C+ TL G+ L + + + + C++P CD+ C ++GCWGPG C +C+ + CV+ C DE F + +C CH C+ C GP P NC CR ++E CV C KY + C CH C + + Sbjct: 370 SLQQLTGSLLLNHYPVRWQVLPFLLHLDLSKPSRKQFWRLHVLLVHKSLLFMLMRYCTYV-KSFQVTATVHPIFCFVSTL--FGSSLYSTKSNGRHCCACDRPGKEGYVCDALCSAEGCWGPGPMQCLSCKFHKRGKTCVESCSVLDGDEREFVSG-------------ALCIACHAECMLINGSLTCHGPGPDNCT-RCRNYREGPHCVGFCPEGVPGESGELIYKYPDEDGVCHPCHYNCTQGE 598 HSP 3 Score: 60.8474 bits (146), Expect = 1.782e-9 Identity = 56/215 (26.05%), Postives = 90/215 (41.86%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRV-----IANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL--------ITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDC 766 NC V GNL I + + DL FL +I EV+G + + N + + L NL+V+RG L ++ ++V ++ D + +LR+ I VY + K LP W+++ K+ + CH C +N +CW S +CQ + + K + CY G C + C GC GP+ +DC Sbjct: 27 NCEVVMGNLEITYI---RNGSDLSFLRTIREVSGYVLIALNEVDHVPLENLRVVRG-TRLYDQRYALTVLLNYNDSVPEERLGLKELRLTRLTEILRGGVYVR---KEPGLPS---WDDIRNRNSKENFFLPVVACDFSSVSLSGQPCHPSC-KN---FCWGSGPQYCQTFTSTICAKQCDGR-CY-----GLDPNQCCHKHCASGCTGPRETDC 221
BLAST of epidermal growth factor receptor 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005822.1 (pep scaffold:Pmarinus_7.0:GL476959:64997:68848:-1 gene:ENSPMAG00000005273.1 transcript:ENSPMAT00000005822.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 170.629 bits (431), Expect = 1.440e-48 Identity = 81/185 (43.78%), Postives = 117/185 (63.24%), Query Frame = 3 Query: 2988 GMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR-PMKKDKHRLLSQISYD 3539 GM YLE R ++HRDLA RNVL+ ++ITDFGLA ++ N+ E GG++PI+WLALE++ I++H++DVWS+G+TLWE+ T+G +PYD + R+I L +G RL QP IC++D+Y +M +CW +A RP F L + S + PT YL I D ++ P D L S + D Sbjct: 1 GMNYLEDRRLVHRDLAARNVLVKAPNHVKITDFGLAKLLDL---NETEYHSEGGKLPIKWLALESIQQRIFTHQSDVWSYGVTLWELMTFGGKPYDGVPARDIPELLEKGERLTQPPICTIDVYMIMVKCWMIDAESRPKFRELAAEFSKMARDPTRYLVIQGDERMKLPSPTDSRFLQSLMEED 182
BLAST of epidermal growth factor receptor 2 vs. Ensembl Sea Lamprey
Match: frk (fyn-related Src family tyrosine kinase [Source:ZFIN;Acc:ZDB-GENE-110411-7]) HSP 1 Score: 179.104 bits (453), Expect = 1.545e-48 Identity = 100/275 (36.36%), Postives = 153/275 (55.64%), Query Frame = 3 Query: 2646 KPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKH-KSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLN 3467 K +G G FG V++G+W +S VAVK ++ + +E + EA++M + H + ++L +C + E +IT + GSL YLR L + L+ QIA GM YLE + IHRDLA RN+L+ + ++ ++ DFGLA I++ +++ E +G +VPI+W A E + +S K+DVWSFGI L+E+ TYG PY E+ E+ L +G R+ QP+ C Y +M CW + +RP+FETL L F P Y + Sbjct: 193 KRLGAGMFGEVWQGLWN-----------NSTLVAVKTLKPG-AMKKEEFIGEAQIMKQLRHANLIQLYAVCSQEEPIYIITELMRHGSLLDYLRGPLGKQLKAPELVDMARQIAAGMAYLESQNYIHRDLAARNILVGEGKVCKVADFGLARIIKVRYEDEYE-GKAGAKVPIKWTAPEAVNFHRFSVKSDVWSFGILLYELITYGRMPYPEMGNMEVLKQLDRGYRMPQPDNCPPLFYSIMLECWNKKEEERPTFETLQWRLDYFDSDPNNYTD 454
BLAST of epidermal growth factor receptor 2 vs. Ensembl Sea Lamprey
Match: fgfr2 (fibroblast growth factor receptor 2 [Source:NCBI gene;Acc:352940]) HSP 1 Score: 179.874 bits (455), Expect = 1.729e-47 Identity = 101/280 (36.07%), Postives = 160/280 (57.14%), Query Frame = 3 Query: 2646 KPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANR-NIDIQEIMEEAKVMASVC-HKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHK----------------STLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTL 3431 KP+G G FG V + D EK +R SL VAVK+++ + + D+ +++ E ++M ++ HK+ + L+G C + +I F G+L ++LR + L + L+S+ Q+A GM YL + IHRDLA RNVL+ D +++I DFGLA V + K S G++P++W+A E L + +Y+H++DVWSFG+ LWEIFT G PY + V E+ L +G+R+ +P +CS +LY +M CW + RP+F+ L+ L Sbjct: 280 KPLGEGCFGQVVMA--EALGIDKEKPNR-SLRVAVKMLKEDATDKDLYDLVSEMEMMKNIGKHKNIINLLGACTQGGPLYVIVEFAAKGNLREFLRARRPPGTEYTFEGAAAAQGEQLSIKELVSFTYQVARGMEYLASKKCIHRDLAARNVLVTDDNVMKIADFGLARDVNYIDYYKK---TSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDRPALCSTELYMMMKDCWAAVPSHRPTFKQLVEDL 553
BLAST of epidermal growth factor receptor 2 vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072]) HSP 1 Score: 97.8265 bits (242), Expect = 6.561e-21 Identity = 68/258 (26.36%), Postives = 127/258 (49.22%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLK-YEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLM 3422 IG G++G VY+ + K +++ VA+K + + ++ +IM E ++ ++ H + ++ G K YE+ L+ + GSL + + + + L ++ Q G+ YL G+IHRD+ N+LL+ +++ DFG++ IV N + + ++G + W+A E L N S +D+WS G T+ E+ T PY L I Y ++ + P S L + +C+ +N RP+ + L+ Sbjct: 31 IGRGSYGVVYKAINKHTDQV----------VAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLE-YCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIV-----NSSALTLAGT---LNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNP-PYHNLTDANIY-YAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLL 267
BLAST of epidermal growth factor receptor 2 vs. Ensembl Yeast
Match: SKM1 (Member of the PAK family of serine/threonine protein kinases; similar to Ste20p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth; SKM1 has a paralog, CLA4, that arose from the whole genome duplication [Source:SGD;Acc:S000005473]) HSP 1 Score: 86.6557 bits (213), Expect = 1.071e-17 Identity = 85/300 (28.33%), Postives = 128/300 (42.67%), Query Frame = 3 Query: 2604 LLIPTTDLIFNINTKP-------IGTGAFGAVY--RGVWKPSNKD--LEKSDRDSL---DVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLI-GICLKYEMPCLITTFVELGSLDKYLR--------KHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGN---RLAQPEICSVDLYQLMCRCWYENANDRPSFETLMS 3425 +++ + ++N +P G GA GAVY + + P D KS + VA+K IR + Q IM E VM ++ + + + E +I ++E G L L +H S L + ++ G+ +L + IIHRD+ + N+LLN +++ITDFG V+ TE + G W+A E + Y K DVWS GI L E+ GE PY D + YLI N +L PE S Q + C N R S L++ Sbjct: 343 IIMKMKTVAIDVNPRPYFQLVEKAGQGASGAVYLSKRIKLPQENDPRFLKSHCHRVVGERVAIKQIRLSEQPKKQLIMNELLVMNDSRQENIVNFLEAYIIDDEELWVIMEYMEGGCLTDILDAVARSNTGEHSSPLNENQMAYIVKETCQGLKFLHNKKIIHRDIKSDNILLNSQGLVKITDFGFC--VELTEKRSKRATMVGTPY---WMAPEIVNQKGYDEKVDVWSLGIMLIEMIE-GEPPYLNEDPLKAL-YLIANNGSPKLRHPESVSKQTKQFLDACLQVNVESRASVRKLLT 635
BLAST of epidermal growth factor receptor 2 vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999]) HSP 1 Score: 81.6481 bits (200), Expect = 5.392e-16 Identity = 77/268 (28.73%), Postives = 121/268 (45.15%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLI-GICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGE------QIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPY-DELDVREITSYLIQGN---RLAQPEICSVDLYQLMCRCWYENANDRPSFETLM 3422 IG GA G VY +N + VA+K + + + I+ E VM H + + I LK ++ +I ++E GSL + T C +L+ G+ + G+ +L +G++HRD+ + N+LL+ I++TDFG Q E N + G W+A E + Y K D+WS GI + E+ GE PY +E +R + YLI N +L +PE S L + + C DR S L+ Sbjct: 626 IGQGASGGVYTAYEIGTN----------VSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGDL-WVIMEYMEGGSLTDVV-----THC---ILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGFC--AQINELNLKRTTMVGTPY---WMAPEVVSRKEYGPKVDIWSLGIMIIEMI-EGEPPYLNETPLRAL--YLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELL 866
BLAST of epidermal growth factor receptor 2 vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242]) HSP 1 Score: 79.337 bits (194), Expect = 2.695e-15 Identity = 76/277 (27.44%), Postives = 127/277 (45.85%), Query Frame = 3 Query: 2655 GTGAFGAVYRG--VWKPSNKDLEKSDRDSLD-------VAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPC-LITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIA-------DGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPY-DELDVREITSYLIQGN---RLAQPEICSVDLYQLMCRCWYENANDRPSFETLM 3422 G GA G+VY P+ ++ + + +D VA+K + ++ + I+ E VM HK+ + + L+ + ++ F+E GSL + + S + L+ QIA G+ +L + IIHRD+ + NVLL+ ++ITDFG + T+ + G W+A E + Y K DVWS GI E+ GE PY +E ++ + YLI N +L PE S+++ + + C + R S E L+ Sbjct: 553 GQGASGSVYLAERTHIPTESNMIELINNDIDEPHVGDKVAIKQMVLSKQPRKELIVNEILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLT-EPQIAYIVRETCQGLKFLHDKHIIHRDIKSDNVLLDTRARVKITDFGFC--ARLTDKRSKRATMVGTPY---WMAPEVVKQREYDEKIDVWSLGIMTIEMLE-GEPPYLNEDPLKAL--YLIATNGTPKLKHPESLSLEIKRFLSVCLCVDVRYRASTEELL 820
BLAST of epidermal growth factor receptor 2 vs. Ensembl Yeast
Match: BCK1 (MAPKKK acting in the protein kinase C signaling pathway; the kinase C signaling pathway controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p; MAPKKK is an acronym for mitogen-activated protein (MAP) kinase kinase kinase [Source:SGD;Acc:S000003631]) HSP 1 Score: 76.6406 bits (187), Expect = 2.006e-14 Identity = 68/271 (25.09%), Postives = 123/271 (45.39%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSN-----KDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETL-LNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEIC--SVDLYQLMCR-----CWYENANDRPSFETLMS 3425 IG G+FGAVY + + K +E S + A+ ++ + E + + H + ++ +G K + L +V GS+ +R + + Q+ G+ YL +GI+HRD+ N+LL+ I +I+DFG++ + N +++ + G + W+A E + YS K D+WS G + E+F G+RP+ L+V + + G + P I ++ L + R C+ N RP+ L+S Sbjct: 1181 IGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQNEAILST-------VEALRSEVSTLKDLDHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMY-GRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSN-SDMTMRGT---VFWMAPEMVDTKQGYSAKVDIWSLGCIVLEMFA-GKRPWSNLEV--VAAMFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEINPEKRPTANELLS 1436
BLAST of epidermal growth factor receptor 2 vs. Ensembl Nematostella
Match: EDO47195 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN18]) HSP 1 Score: 184.111 bits (466), Expect = 7.829e-52 Identity = 102/273 (37.36%), Postives = 154/273 (56.41%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKST-LCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLN 3467 +G G +G VY G WK NK VAVK +R ++++E ++EA VM + H++ ++L+G+C + +IT F+ G+L YLR K L + TL+ Q+ M+YLE IHRDLA RN L+ D ++++ DFGL+ +V +ED G + PI+W A E L + +S K+DVW+FGI LWE+ TYG PY +D+ ++ L G R+ PE C ++Y LM CW + N RPSF+ + L+ FP+ +N Sbjct: 20 LGGGQYGEVYEGTWKKYNKT----------VAVKTLR-EETMEVEEFLKEASVMKGIKHQNLVQLLGVCTREPPFYIITEFMMNGNLLDYLRSPKGKDLDAVTLMYMATQVGSAMSYLESMNFIHRDLAARNCLVGDNNLVKVADFGLSRLV--SEDIYT--AHQGAKFPIKWTAPEALAHNTFSIKSDVWAFGILLWELATYGMSPYPGIDLSQVYDKLDGGYRMPCPEGCPPEVYSLMQTCWCWDPNSRPSFKEIHEKLNTM--FPSSNVN 275
BLAST of epidermal growth factor receptor 2 vs. Ensembl Nematostella
Match: EDO47094 (Predicted protein; Vascular endothelial growth factor receptor-like protein [Source:UniProtKB/TrEMBL;Acc:A7RN88]) HSP 1 Score: 168.703 bits (426), Expect = 2.114e-46 Identity = 101/282 (35.82%), Postives = 151/282 (53.55%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPS---NKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASV-CHKHCLRLIGICLKYEMPCL--ITTFVELGSLDKYLRK---------------HKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTL 3431 +G+GAFG VY G + + S R ++ VA+K ++ Q +++ E K++ V HK+ + L+G C K L I F G L YL+K H L+S Q+A GM +L R IHRDLA RNVL+ D ++++ DFGLA V N+ + + G VPI+W+A+E+L + IYS K+DVWS+G+ LWEIFT G PY +L ++ YL+ G R+ +P C+ ++Y +M CW + DRP+F L+ L Sbjct: 22 LGSGAFGQVYLGETEGGIDYRRPSAISMRGNIKVAIKTLKGGATESEQKDLLSELKILIHVGSHKNIVNLLGACTKGPQRDLWIILEFCANGDLLSYLKKKRDIYDPAWCAPSEDHDVQFTQMELVSAAYQVARGMEFLASRRCIHRDLAARNVLIADDYVLKVADFGLARDVY---KNEEYVKHTPGLVPIKWIAIESLTDKIYSQKSDVWSYGVLLWEIFTLGGNPYPDLHPSDVFEYLLDGKRMEKPVDCAQEIYNIMTDCWVLSPEDRPTFTELVKKL 300
BLAST of epidermal growth factor receptor 2 vs. Ensembl Nematostella
Match: EDO47097 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN91]) HSP 1 Score: 167.548 bits (423), Expect = 5.627e-46 Identity = 94/280 (33.57%), Postives = 154/280 (55.00%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANR-NIDIQEIMEEAKVMASVC-HKHCLRLIGICLKYEMPCLITTFVEL---GSLDKYLRKHK---------------STLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTL 3431 +GTGAFG V+ + + S++ VA K ++ N + + ++++ E K++ + HK+ + L+G C K C + +E G+L +LRK + T L+ Q++ M +L R +HRDLA RNVL+ + +++I DFGLA + E + + + G +P++W+A+E L++ +Y+H +DVWSFG+ LWEIFT G PY L E+ YL++G R+AQPE C ++Y LM RCW + RP+F L+ T+ Sbjct: 22 VGTGAFGQVFLA------EAVGISNKQVTRVACKGLKENATDSEYRDLLSELKILMHIGEHKNIVNLLGACTKGR-ECDLLVIIEYCPHGNLLNFLRKRRDVFEATWSPPTEKPDETFTLTDLVITSFQVSRAMQFLASRRCVHRDLAARNVLVGENYVMKIADFGLARDIYKEE---HYVKTTAGLLPVKWMAIEALVDQVYTHSSDVWSFGVLLWEIFTLGGSPYPGLPANEVYQYLMEGQRMAQPEDCPQEMYDLMLRCWQHDPAQRPTFTQLLETI 291
BLAST of epidermal growth factor receptor 2 vs. Ensembl Nematostella
Match: EDO33736 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRD7]) HSP 1 Score: 167.548 bits (423), Expect = 6.140e-45 Identity = 91/259 (35.14%), Postives = 141/259 (54.44%), Query Frame = 3 Query: 2652 IGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLA-HIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLM 3422 IG G F VYRGV +K EK VAVK+++ + + + ++ EA +M H + + L G+ + +IT F+E GSLD +L+ + L + L+ G +A GM YL IHRDLA RN+L++D +++DFGL+ + E+ ++E GG++P+RW A E + +S +DVWS+GI LWEI ++GERPY D ++ + G RL P C ++ LM CW + RP F ++ Sbjct: 33 IGGGEFADVYRGVLTNEDKTQEK-------VAVKILKPGSSHKNREDFCVEASIMGQFDHPNVIALKGVITRTRPMMIITEFLENGSLDNFLKSNDGRLTTLQLVGIGRGVAAGMAYLSEMNFIHRDLAARNILVSDNLAAKVSDFGLSRELDDSPENEQSEYQTQGGKIPVRWTAPEAIRYRKFSSASDVWSYGILLWEIMSFGERPYWTWDNFQVMDRVEGGYRLPAPMKCPKVIHNLMLDCWDKEKTSRPKFADIV 284
BLAST of epidermal growth factor receptor 2 vs. Ensembl Nematostella
Match: EDO31298 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYB5]) HSP 1 Score: 163.696 bits (413), Expect = 6.784e-45 Identity = 95/256 (37.11%), Postives = 142/256 (55.47%), Query Frame = 3 Query: 2646 KPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANR-NIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSF 3410 K +G G FG+V +G +K N + + VAVK ++++ N EI+ EA+VM + H + +R+IG+C M L+ G L+KYL+K+K + +L Q+A+GM YLE +HRDLA RNVL+ + ++I+DFG++ + D + G+ P++W A E + +S K+DVWS+GITLWE +YG RPY L + I + G RL P +YQLM CW +DRPSF Sbjct: 30 KELGHGNFGSVLKGTYKMPNGE-------RIPVAVKSLKSDDINNPKSEILHEARVMMELDHPYIVRIIGMCQGPSM-MLVMELAGEGPLNKYLKKNKG-MPLLNILVLMLQVAEGMQYLESLQFVHRDLAARNVLVVNDSFVKISDFGMSRAMGAGSDYYK--AGTAGRWPLKWYAPECIYFRKFSSKSDVWSYGITLWEATSYGARPYQSLSGQAILEKIESGYRLPAPAKLPSCVYQLMKDCWQWEQDDRPSF 274
BLAST of epidermal growth factor receptor 2 vs. Ensembl Medaka
Match: egfra (epidermal growth factor receptor [Source:NCBI gene;Acc:101159776]) HSP 1 Score: 259.225 bits (661), Expect = 5.106e-71 Identity = 170/480 (35.42%), Postives = 254/480 (52.92%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCVE-RCTVTPNDPFQCGSC-NFK-RLYLDNHNKSCVSECPQ-------THKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLIS-SVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C C Y G RCV C I PR N +C C+ C T T + P C C NF+ LY CVS CPQ T +K+ D +C Q + + ++ ++TV + SV++ R I +K++++ L + E + L PN L ++ ++ K +G+GAFG VY+G+W P +D++ + VA+KV+R A +EI++EA VMASV + H RL+GICL + LIT + G L Y+++ K + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ ++ITDFGLA ++ E E GG+VPI+W+ALE++L Y+H++DVWS+G+T+WE+ T+G +PYD + EI L +G+RL QP IC++D+Y +M +CW +A RP F L+ + + P+ YL I D Sbjct: 440 CFACRDYSRGGRCVDSCN-ILEGEPREAVMNKTCVECDPECQRMNGTATCSGPGNCAKCANFQDGLY-------CVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCT----QGSTGLSMIAAGVVGGLLTVLVTGLSVFVLLRR-RYIKRKRTMRRL------LQERELVEPLTPSGQAPNQALLRILKESEFK---KIKVLGSGAFGTVYKGLWVPEGEDVK------IPVAIKVLREATSPKANKEILDEAYVMASVENPHVCRLLGICLTSTVQ-LITQLMPYGCLLDYVKEKKDNIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPNHVKITDFGLAKLLNADE---KEYHADGGKVPIKWMALESILTRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGDRLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIGEFTKMARDPSRYLVIQGD 887 HSP 2 Score: 87.4261 bits (215), Expect = 4.456e-31 Identity = 95/336 (28.27%), Postives = 131/336 (38.99%), Query Frame = 3 Query: 900 VQEVDACIYSCNSLHFYRVDN----KCIRCQNSSVCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITL-PMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRC---EDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ-----NCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMEN 1832 V + AC+ +C S + Y VD KC +C C K + + KN T I I H T+ DK + P V+ ITG L I + +L+ +NL+ IR T+ S ++ I D+ +LGLR L+ I G + + LCY + +W G Q N CD KC + GCWGPG MC+ CR + CVD C E EP A+ T C C P C + C+G P NC C F++ CV C + KY C CH+ C + Sbjct: 232 VTDHGACVRTC-SGNTYEVDEGGIRKCAKCNGP--CPKVCNGLGTGNLTHTLSINATNIDSFKNCTKINGNIAFIH-TSIYGDKFTKTPKMDPAKLDVFKTVKEITGYLWIQTWPKNMSSLSPFENLEIIRGR-TKQGSRSVAITQLDISYLGLRSLKEISDGDVVIIKNHNLCYTNRSHWKGLFKSKTQT-----LMNSTCDRKCAADGCWGPGPDMCFACRDYSRGGRCVDSCNILEGEP-----REAVMNKT-------CVECDPECQRMNGTATCSG--PGNC-AKCANFQDGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQG 542 HSP 3 Score: 68.9366 bits (167), Expect = 4.456e-31 Identity = 66/250 (26.40%), Postives = 97/250 (38.80%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NCT V NL I + + DL FL SI EV G + + N+ I L NL++IRG S+Y ++A L V+ N+ + + K +CHS C CW+ +CQ +K ++ + C + + G C+E C GC GP+ +DC C+ + + C + CP YD L NPN K G C +CP Sbjct: 34 NCTVVLENLEITYM---DNNHDLSFLKSIEEVGGYVLIALNTATRIPLENLRIIRGH----------SLY-------EGEFA----LSVLVNS-----------------------DKGTGTTELLLTKLTGKKCHSSCFNGS---CWAPGPQYCQTLTK-----LNCAQQCSKRCK-GPSPSDCCNEHCAAGCTGPRPTDCLACRDFRDDGVCKDSCPGLMRYDPNLHLLVPNPNGKYSFGATCVKNCP 227
BLAST of epidermal growth factor receptor 2 vs. Ensembl Medaka
Match: ENSORLT00000004471.2 (melanoma receptor tyrosine-protein kinase [Source:NCBI gene;Acc:101169984]) HSP 1 Score: 259.61 bits (662), Expect = 2.111e-70 Identity = 139/360 (38.61%), Postives = 217/360 (60.28%), Query Frame = 3 Query: 2415 SLIILSVITVFLISSVYIFFRYV----NKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 S + + V++ L++ + + F V +I +K++++ L + E + L PN L ++ T+ + +G+GAFG V++G+W P +++ + VA+KV+R A QE+++EA VMASV H H RL+GICL + L+T + G L Y+R+HK +C++ LL+W QIA GM YLE R ++HRDLA RNVLL + I+ITDFGLA ++ T D K E GG+VPI+W+ALE++L Y+H++DVWS+G+T+WE+ T+G +PYD + EI + L +G RL QP IC++D+Y +M +CW + + RP F+ L+ S + P+ YL I D Sbjct: 664 SSLAVGVVSGLLVAVIVLLFVLVYVRRQRIKKKRTLRRL------LQEKELVEPLTPSGQAPNQALLRILKETEFK---KVRVLGSGAFGTVFKGLWVPEGENVR------IPVAIKVLREATSPKANQEVLDEAYVMASVDHPHVCRLLGICLTSSVQ-LVTQLMPYGCLLDYVRQHKDRICAQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHIKITDFGLAKLL--TADEK-EYHADGGKVPIKWMALESILQWTYTHQSDVWSYGVTVWELMTFGSKPYDGIAASEIATVLERGERLPQPPICTIDVYMIMVKCWMIDPSSRPKFKELIMEFSQMARDPSRYLVIRGD 1004 HSP 2 Score: 115.546 bits (288), Expect = 1.818e-25 Identity = 90/310 (29.03%), Postives = 134/310 (43.23%), Query Frame = 3 Query: 1044 DVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLG---NVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTD-LEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPC------NKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCL-----QNCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCS 1892 + + ++ +++F + + G+ F SF PM K L V+ ITG L+I + +L+ +NL+ IR + ++ D L +LGLR L+ + G + D+ LCY+ +NW+ Q PP N+ CD +C S+GCWGPG++MC +C+ F +CV+RC G +G C CHP CL Q C GP P C C +FK+ CV+ C KY N C CH+ C + C+G GL GCS Sbjct: 369 NTIAVNSSNIESFRNCTKINGDIVFLKSSFSGDQHYNIPPMDPKKLEYFRTVKEITGHLLIQTWPENMTSLSVFENLEIIRGRSLFVNKYSFVVVGADNLHWLGLRSLKELSAGNVRLKDNKLLCYSKAMNWSYLFRDKTQIVDQTPPVDVCEGQNQTCDQQCSSKGCWGPGTNMCLSCQYFNRKQHCVERCNLLQGEPREVEV---------EGSCVECHPECLVMTGTQTCHGPGPDQC-SQCAHFKDGSHCVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQG------CSGP----GLSGCS 658 HSP 3 Score: 89.3521 bits (220), Expect = 2.015e-17 Identity = 76/263 (28.90%), Postives = 119/263 (45.25%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQN-----SLALEKSEVSVYIDLLDEENS--QYAIFPKLRVIANNSVYFKTKVKHKFL---PQSIKWEELFENPKK-QKLITYNKYME--HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NC+ V NL I +Q DL FL SI EV G + + N + + L NL++IRGQN +L + + S I S + +L I N V KV + L + I+W ++ + + L+ ++ Y +C C+ + CW++ +HCQK +K V E C +G C++ C GC GP +DC CK + + C + CPP +Y+ + ++ NPN K G C +CP Sbjct: 72 NCSVVLENLEITYTLENQ---DLSFLQSIQEVGGYVLIAMNDVATVPLVNLRLIRGQNLYDKFALLVMSNYHSNNITGAPRYTSGLRQLQLSRLTEILNGGV----KVTNNPLLCNMEKIQWWDIVDKARNFSVLLKFDDYKRDCERCDPGCVNDS---CWAAGPDHCQKFTKLVCA-----EQCGPGRCSGPKPLDCCNQHCAAGCTGPLATDCLACKNFNDDGICKDSCPPLNLYNHKSQQVVENPNAKYSFGATCVKACP 319
BLAST of epidermal growth factor receptor 2 vs. Ensembl Medaka
Match: ENSORLT00000004469.2 (melanoma receptor tyrosine-protein kinase [Source:NCBI gene;Acc:101169984]) HSP 1 Score: 259.225 bits (661), Expect = 2.125e-70 Identity = 139/360 (38.61%), Postives = 217/360 (60.28%), Query Frame = 3 Query: 2415 SLIILSVITVFLISSVYIFFRYV----NKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 S + + V++ L++ + + F V +I +K++++ L + E + L PN L ++ T+ + +G+GAFG V++G+W P +++ + VA+KV+R A QE+++EA VMASV H H RL+GICL + L+T + G L Y+R+HK +C++ LL+W QIA GM YLE R ++HRDLA RNVLL + I+ITDFGLA ++ T D K E GG+VPI+W+ALE++L Y+H++DVWS+G+T+WE+ T+G +PYD + EI + L +G RL QP IC++D+Y +M +CW + + RP F+ L+ S + P+ YL I D Sbjct: 654 SSLAVGVVSGLLVAVIVLLFVLVYVRRQRIKKKRTLRRL------LQEKELVEPLTPSGQAPNQALLRILKETEFK---KVRVLGSGAFGTVFKGLWVPEGENVR------IPVAIKVLREATSPKANQEVLDEAYVMASVDHPHVCRLLGICLTSSVQ-LVTQLMPYGCLLDYVRQHKDRICAQWLLNWCVQIAKGMNYLEERHLVHRDLAARNVLLKNPNHIKITDFGLAKLL--TADEK-EYHADGGKVPIKWMALESILQWTYTHQSDVWSYGVTVWELMTFGSKPYDGIAASEIATVLERGERLPQPPICTIDVYMIMVKCWMIDPSSRPKFKELIMEFSQMARDPSRYLVIRGD 994 HSP 2 Score: 118.242 bits (295), Expect = 2.719e-26 Identity = 90/304 (29.61%), Postives = 136/304 (44.74%), Query Frame = 3 Query: 1044 DVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLG---NVQYITGDLIIDGSNIVLKNLTFLQNLKEIR-HLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCL-----QNCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCS 1892 + + ++ +++F + + G+ F SF PM K L V+ ITG L+I + +L+ +NL+ IR L + + + + +L +LGLR L+ + G + D+ LCY+ +NW+ Q PP N+ CD +C S+GCWGPG++MC +C+ F +CV+RC G +G C CHP CL Q C GP P C C +FK+ CV+ C KY N C CH+ C + C+G GL GCS Sbjct: 366 NTIAVNSSNIESFRNCTKINGDIVFLKSSFSGDQHYNIPPMDPKKLEYFRTVKEITGHLLIQTWPENMTSLSVFENLEIIRGRSLFVNKYSFVVVGADNLHWLGLRSLKELSAGNVRLKDNKLLCYSKAMNWSYLFRDKTQIVDQTPP-NQTCDQQCSSKGCWGPGTNMCLSCQYFNRKQHCVERCNLLQGEPREVEV---------EGSCVECHPECLVMTGTQTCHGPGPDQC-SQCAHFKDGSHCVRMCPHGVLDDENMLIWKYADQNGQCQLCHQNCSQG------CSGP----GLSGCS 648 HSP 3 Score: 89.3521 bits (220), Expect = 2.158e-17 Identity = 76/263 (28.90%), Postives = 119/263 (45.25%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQN-----SLALEKSEVSVYIDLLDEENS--QYAIFPKLRVIANNSVYFKTKVKHKFL---PQSIKWEELFENPKK-QKLITYNKYME--HQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NC+ V NL I +Q DL FL SI EV G + + N + + L NL++IRGQN +L + + S I S + +L I N V KV + L + I+W ++ + + L+ ++ Y +C C+ + CW++ +HCQK +K V E C +G C++ C GC GP +DC CK + + C + CPP +Y+ + ++ NPN K G C +CP Sbjct: 69 NCSVVLENLEITYTLENQ---DLSFLQSIQEVGGYVLIAMNDVATVPLVNLRLIRGQNLYDKFALLVMSNYHSNNITGAPRYTSGLRQLQLSRLTEILNGGV----KVTNNPLLCNMEKIQWWDIVDKARNFSVLLKFDDYKRDCERCDPGCVNDS---CWAAGPDHCQKFTKLVCA-----EQCGPGRCSGPKPLDCCNQHCAAGCTGPLATDCLACKNFNDDGICKDSCPPLNLYNHKSQQVVENPNAKYSFGATCVKACP 316
BLAST of epidermal growth factor receptor 2 vs. Ensembl Medaka
Match: egfra (epidermal growth factor receptor [Source:NCBI gene;Acc:101159776]) HSP 1 Score: 255.758 bits (652), Expect = 3.091e-69 Identity = 168/484 (34.71%), Postives = 251/484 (51.86%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQCFPIALNLPR----NASCPYCNGNCVE---RCTVTPNDPFQCGSC-NFK-RLYLDNHNKSCVSECPQ-------THKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLIS---SVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIR-ANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C C Y G RCV C I PR N +C C+ C T + + P C C NF+ LY CVS CPQ T +K+ D +C K S LS+I ++ +V + V + +++ +K + + + E + L PN L ++ ++ K +G+GAFG VY+G+W P +D++ + VA+KV+R A +EI++EA VMASV + H RL+GICL + LIT + G L Y+++ K + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ ++ITDFGLA ++ E E GG+VPI+W+ALE++L Y+H++DVWS+G+T+WE+ T+G +PYD + EI L +G+RL QP IC++D+Y +M +CW +A RP F L+ + + P+ YL I D Sbjct: 515 CFACRDYSRGGRCVDSCN-ILEGEPREAVMNKTCVECDPECQRMNGTATCSASGPGNCAKCANFQDGLY-------CVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQGCTGPGLKGCHIKSSTGLSMIAAGVVGGLLTVLVTGLSVFVLLRRRYIKRKRTMRRLLQERELVEPLTPSGQAPNQALLRILKESEFK---KIKVLGSGAFGTVYKGLWVPEGEDVK------IPVAIKVLREATSPKANKEILDEAYVMASVENPHVCRLLGICLTSTVQ-LITQLMPYGCLLDYVKEKKDNIGSQHLLNWCVQIAKGMNYLEERHLVHRDLAARNVLVKTPNHVKITDFGLAKLLNADE---KEYHADGGKVPIKWMALESILTRTYTHQSDVWSYGVTVWELMTFGTKPYDGIPASEIAGILEKGDRLPQPPICTIDVYMIMVKCWMIDAESRPRFRELIGEFTKMARDPSRYLVIQGD 977 HSP 2 Score: 88.5817 bits (218), Expect = 1.366e-36 Identity = 102/363 (28.10%), Postives = 139/363 (38.29%), Query Frame = 3 Query: 900 VQEVDACIYSCNSLHFYRVDN----KCIRCQNSSVCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITL-PMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPI-----YPPC---NKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRC---EDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ-----NCTGPRPTNCIGGCRYFKENDECVKNCSR-----------KYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGC 1889 V + AC+ +C S + Y VD KC +C C K + + KN T I I H T+ DK + P V+ ITG L I + +L+ +NL+ IR T+ S ++ I D+ +LGLR L+ I G + + LCY + +W G Q + C N CD KC + GCWGPG MC+ CR + CVD C E EP A+ T C C P C + C+ P NC C F++ CV C + KY C CH+ C + CTG GL GC Sbjct: 294 VTDHGACVRTC-SGNTYEVDEGGIRKCAKCNGP--CPKVCNGLGTGNLTHTLSINATNIDSFKNCTKINGNIAFIH-TSIYGDKFTKTPKMDPAKLDVFKTVKEITGYLWIQTWPKNMSSLSPFENLEIIRGR-TKQGSRSVAITQLDISYLGLRSLKEISDGDVVIIKNHNLCYTNRSHWKGLFKSKTQSANVDENASATACALMNSTCDRKCAADGCWGPGPDMCFACRDYSRGGRCVDSCNILEGEP-----REAVMNKT-------CVECDPECQRMNGTATCSASGPGNC-AKCANFQDGLYCVSRCPQGVPGEDDTLVWKYADERNVCQLCHKNCTQG------CTGP----GLKGC 628 HSP 3 Score: 86.2705 bits (212), Expect = 1.366e-36 Identity = 73/253 (28.85%), Postives = 112/253 (44.27%), Query Frame = 2 Query: 161 NCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL---ITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 NCT V NL I + + DL FL SI EV G + + N+ I L NL++IRG SL + +SV ++ + + KL I + F ++I+W ++ KK K+ + N + +CHS C CW+ +CQ +K ++ + C + + G C+E C GC GP+ +DC C+ + + C + CP YD L NPN K G C +CP Sbjct: 52 NCTVVLENLEITYM---DNNHDLSFLKSIEEVGGYVLIALNTATRIPLENLRIIRGH-SLYEGEFALSVLVNSDKGTGTTELLLTKLTEILAGGIKFGNNQLCNV--ETIQWFDIVNPDKKPKMELPMASNNPLCKKCHSSCFNGS---CWAPGPQYCQTLTK-----LNCAQQCSKRCK-GPSPSDCCNEHCAAGCTGPRPTDCLACRDFRDDGVCKDSCPGLMRYDPNLHLLVPNPNGKYSFGATCVKNCP 289
BLAST of epidermal growth factor receptor 2 vs. Ensembl Medaka
Match: erbb4a (receptor tyrosine-protein kinase erbB-4 [Source:NCBI gene;Acc:101165379]) HSP 1 Score: 246.514 bits (628), Expect = 6.089e-66 Identity = 165/491 (33.60%), Postives = 250/491 (50.92%), Query Frame = 3 Query: 2088 CEKCNGYWSGDRCVKQC--FPIALNLPRNAS-CPYCNGNCVE----RCTVTPNDPFQCGSC-NFKRLYLDNHNKSCVSECPQTHK------YKHKDGNLT----DIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIY----SNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQ-EIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLR 3491 C C + G CV+ C F + N S C C+ C + T P QC C NFK D N CV +CP + +K+ N + C Q+ + + LI +I I + I V ++KS+K +A+ + + EP L T PN +L ++ T+L K +G+GAFG VY+G+W P + ++ + VA+K++ E M+EA +MASV H H +RL+G+CL + L+T + G L Y+ +HK + S+ LL+W QIA GM YLE R ++HRDLA RNVL+ I+ITDFGLA ++ E N GG++PI+W+ALE + ++H++DVWS+G+T+WE+ T+G +PYD + REI L +G RL QP IC++D+Y +M +CW +A+ RP F+ L + + P YL I D ++ Sbjct: 463 CLSCRYFKRGRTCVESCNLFNGEVREFANGSVCLECDSQCEKMDGNSLTCLGQGPDQCVKCLNFK----DGPN--CVEKCPDGLQGANSFIFKYAKANNECHPCHVNCTQGCIGPRIQDCVGMMDRTPLIAAGIIGGLFI--IVIVALTVAIYARRKSIKKKRALRRFLETELVEP-----LTPSGTAPNQAQLRILKETELK---RVKILGSGAFGTVYKGIWVPEGETVK------IPVAIKILNEATGPKANVEFMDEALIMASVEHPHLVRLLGVCLSPTIQ-LVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVLVKSPNHIKITDFGLARLLDADEKEYNA---DGGKMPIKWMALECIHYRKFTHQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKELAAEFCRMARDPQRYLVIQGDDRMK 927 HSP 2 Score: 99.7525 bits (247), Expect = 1.533e-20 Identity = 75/251 (29.88%), Postives = 116/251 (46.22%), Query Frame = 2 Query: 179 GNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAI----FPKLRVIANNSVYFKTKVKHKFL--PQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCV-KEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKL--NPNFKLRVGYMCANSCP 904 GNL I ++ + +L FL SI EVTG + + N + + L NL++IRG L + ++ I L + Y + L I N VY ++KFL +I W+++ +NP+ + L+ + + C C R+ CW + CQ +K V E+ D C+ G C +C GGC GPK++DC C + + CV CP F+Y+ + +L NP K G C CP Sbjct: 2 GNLEITSI---DRNRNLSFLKSIREVTGYVLVALNQFEYLPLENLRIIRGT---TLYEGRYALAIFLNYRRDGNYGLKQLGLRSLTEILNGGVYVD---QNKFLCHADTIHWQDVIKNPQAELLVVPSNNSNNGCRR-CHRSCNGRCWGHQEDQCQTLTKTVCAEQCDG--RCF-----GPYVSDCCHRECAGGCFGPKDTDCFACTNFNDSGACVTQCPQPFVYNPTSFQLEHNPRAKYTYGAFCVRECP 235 HSP 3 Score: 69.707 bits (169), Expect = 2.129e-11 Identity = 64/244 (26.23%), Postives = 97/244 (39.75%), Query Frame = 3 Query: 1188 VQYITGDLIIDGSNIVLKNLTFLQNLKEI--RHLLTQSASAALNIMHTDLEFLGLRKLRRI-FGKFEVHDSPGLCYADTLNWTG-------NILKNNQFDPIYPPCNKP---CDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQ------NCTGPRPTNCIGGCRYFKENDECVKNCSR----------KYFSFNKTCIKCHETCMEN 1832 V+ ITG L I + +L+ NL I R L + S + L + + + L I G + ++ LC+ +T+NWT +L N +P+ C + CD C GCWGPG C +CR F+ CV+ C G ++++ + +C C C + C G P C+ C FK+ CV+ C KY N C CH C + Sbjct: 336 VKEITGFLNIQSWPENMTDLSVFSNLVTIGGRSLYSGSGISLLILKQRRISSFQFQSLNEISAGNVYIFNNSRLCFYNTINWTSLFRTPSQKVLIRNNREPME--CLQQQMICDRMCSEDGCWGPGPDQCLSCRYFKRGRTCVESCNLFNG------EVREFANG---SVCLECDSQCEKMDGNSLTCLGQGPDQCV-KCLNFKDGPNCVEKCPDGLQGANSFIFKYAKANNECHPCHVNCTQG 567 HSP 4 Score: 56.9954 bits (136), Expect = 1.412e-7 Identity = 77/330 (23.33%), Postives = 121/330 (36.67%), Query Frame = 3 Query: 1254 LQNLKEIRHLLTQSASAALNIM-------HTDLEFLGLRKLRRIF-GKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCN------KPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCV 2201 L+NL+ IR AL I + L+ LGLR L I G V + LC+ADT++W +++KN Q + + P N + C C+ + CWG C C RC + + CH C C GP+ T+C C F ++ CV C + F +N T + +E++ G ++C + + F C R NK+++ E I +C PC + C + C+G +G Q A N+ + +C NGN + Sbjct: 40 LENLRIIRGTTLYEGRYALAIFLNYRRDGNYGLKQLGLRSLTEILNGGVYVDQNKFLCHADTIHWQ-DVIKNPQAELLVVPSNNSNNGCRRCHRSCNGR-CWGHQEDQCQTLTKTVCAEQCDGRC-------------------FGPYVSDCCHRECAGGCFGPKDTDCF-ACTNFNDSGACVTQCPQP-FVYNPTSFQ-----LEHNPRAKYTYG----------AFC---VRECPHNFVVDHSSCVRACPSNKMEVEE-------NRIKMCIPCTDICPKV------------CDGIGTGSLQTAQTVD-ASNIDKFVNCTKINGNLI 308 HSP 5 Score: 54.299 bits (129), Expect = 1.091e-6 Identity = 32/85 (37.65%), Postives = 41/85 (48.24%), Query Frame = 3 Query: 1485 CDSKCD-----SQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIG 1724 CDS+C+ S C G G C C F+ NCV++C D G S I KY ++ C CH C Q C GPR +C+G Sbjct: 498 CDSQCEKMDGNSLTCLGQGPDQCVKCLNFKDGPNCVEKCPD--GLQGANSFIFKYAKANNE--CHPCHVNCTQGCIGPRIQDCVG 578
BLAST of epidermal growth factor receptor 2 vs. Planmine SMEST
Match: SMESG000004200.1 (SMESG000004200.1) HSP 1 Score: 936.791 bits (2420), Expect = 0.000e+0 Identity = 465/471 (98.73%), Postives = 468/471 (99.36%), Query Frame = 3 Query: 900 VQEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAXXXXXXXXXXXXXXXDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKS--CVSECP 2306 +QEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAKKEFNINKIINEENEDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYL+KIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNC+ERCTVTPNDPFQCGSCNFKRLYL NHNKS CVSECP Sbjct: 298 LQEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAKKEFNINKIINEENEDVFYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLDKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASCPYCNGNCIERCTVTPNDPFQCGSCNFKRLYLHNHNKSFQCVSECP 768 HSP 2 Score: 587.03 bits (1512), Expect = 0.000e+0 Identity = 292/294 (99.32%), Postives = 294/294 (100.00%), Query Frame = 2 Query: 23 MGFVCNXXXXXXXXESSLAIRQFDEEYPGVTICESSMTSGELGGNHNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGYMCANSCP 904 MGFVCNIIVVIILLESSLAIRQFDEEYPGVTICESSMTSGELGGNHNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLA+EKSEVSVYIDLLDEENSQYAIFPKLRVI+NNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGYMCANSCP Sbjct: 1 MGFVCNIIVVIILLESSLAIRQFDEEYPGVTICESSMTSGELGGNHNCTHVEGNLVIQNVWPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLAIEKSEVSVYIDLLDEENSQYAIFPKLRVISNNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCLRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGYMCANSCP 294
BLAST of epidermal growth factor receptor 2 vs. Planmine SMEST
Match: SMESG000004201.1 (SMESG000004201.1) HSP 1 Score: 735.717 bits (1898), Expect = 0.000e+0 Identity = 352/352 (100.00%), Postives = 352/352 (100.00%), Query Frame = 3 Query: 2793 MEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFVGDYQDDIEGEPSLKRQSSGFSWSSKQTRSSQEIDKRLFYFRQHSAVSEDLEENDNFCRSDEQEESDSEYLEPKKIENFK 3848 MEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFVGDYQDDIEGEPSLKRQSSGFSWSSKQTRSSQEIDKRLFYFRQHSAVSEDLEENDNFCRSDEQEESDSEYLEPKKIENFK Sbjct: 1 MEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRLLSQISYDFQVYPKLNNIYKQHSLDGTISTFVGDYQDDIEGEPSLKRQSSGFSWSSKQTRSSQEIDKRLFYFRQHSAVSEDLEENDNFCRSDEQEESDSEYLEPKKIENFK 352
BLAST of epidermal growth factor receptor 2 vs. Planmine SMEST
Match: SMESG000016935.1 (SMESG000016935.1) HSP 1 Score: 643.269 bits (1658), Expect = 0.000e+0 Identity = 368/922 (39.91%), Postives = 532/922 (57.70%), Query Frame = 3 Query: 885 CARIRVQEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAXXXXXXXXXXXXXXXDVFY--------MTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIR-HLLTQSASAALNIMHTDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCNKPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYFSFNK------TCIKCHETCMENDK---NQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQC---FPIALNLPRNASCPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDN-HNK-SCVSECPQTHKY-KHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSV---ITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKT-IPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWKPSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPNDSCLRPMKKDKHRL----LSQISYDFQVYP 3554 C + + C+Y C+ ++ N+CI C N + K+ N D FY + L T+ ++G+ SF+K G+T+PMLY HL NV+ I G + + NLTFL NL+EIR + + + ++A+NI +EFLGL+KL++++GK + + G CY D + W I +N+ + CNK CD C Q CWGPG+ MCY+C ++A +CV +C D PG++ + + K CQ CHPLC QNCTGP P NC G CRY E + CVKNCS +F TC CH +C + CTG S+ILG GGCS C KLI + ++ C+K CP+ +Y + I+ + +K C+PC C CSG C +C GY+ ++CVK+C + + L CP C+ C C + ND C C +L++D+ NK SCV+ CP + +++DG D IC+ + ++ ++ K IILS VF+I ++FR+ + NQ + + +KA+YSN EPD + + ++ T PNM R+ +IP +DL+F+ ++KP+G+GAFG VYRG WK +D + +L+V +KVI + E +EEAK+MASV H+HCL LIG+CL E PCL++T+ + GSLDKYL+++ + S ++L W +QIADGM YL RGIIHRDLA RNVL+ND + IQITDFGLA +V T+D+ IVI G+VPIRWLA+ETLL+ YS TDVW++G+TLWEIFTY +RPY+EL EI S+L QGNRL QPEI ++++Y +M +CW ++ + RPSF L+ST F Q P +L +P++ + KD+ + L+QIS D P Sbjct: 310 CPASLLDQNKICVYECDFDAHQKIGNRCIECPNGN--CNSSTAGYKLCNLATIDKFYPKNNRKYSLNKQTLMQLTNCTLILGDLDIDDISFNK--NGVTVPMLYHHLKNVREIIGLFSLVTFRTKISNLTFLSNLEEIRLSVKSHTVASAMNIHGKYIEFLGLKKLKKVYGKISIGGTNGTCYLDRIPWE-EISPDNR---VKFSCNKTCDPLCTGQ-CWGPGNEMCYSCAYYKAGNSCVKQCSDSPGYFASQTEFKTIK-------CQTCHPLCRQNCTGPTPKNCGGQCRYAIEENTCVKNCSIDFFPVANNVNAPITCQLCHSSCFVDKTLVGTNHACTGPSNILGTGGCSKCEKLIKTSNNQYLCHKGSCPKGFYQSVINQNISHLHKKIVHQSSCEPCHSMCRTCSGPTNEKRMCHQCKGYFLDNKCVKECDNMKNVTMKLEIGDECPQCHKECRNGCLLA-NDSTACTRCLNHKLFVDDDKNKFSCVTRCPHDRNFTEYQDG---DFICLKFEETINSKQR-----KTIFIILSGCFGFLVFIIGFCVLYFRW--RANQTRILAEIKALYSNFKEPDMKNMKEDYITRPPNMRRMQMIPISDLVFDTSSKPLGSGAFGKVYRGYWKVPRQD---NKYINLEVVIKVIHNSSKGSTDEFLEEAKIMASVSHRHCLPLIGVCLSLEKPCLVSTYAQHGSLDKYLQQNSKKISSHSMLKWAKQIADGMAYLNKRGIIHRDLAARNVLVNDDDNIQITDFGLARLVDETDDS---IVIKSGKVPIRWLAIETLLSATYSPATDVWAYGVTLWEIFTYAKRPYEELATGEIKSFLQQGNRLCQPEISTLEVYMVMIKCWLDDPHMRPSFMELVSTFEQFIQSPKRFLYMPHEYVNQQYPKDEDQREMIQLNQISIDSDFRP 1198 HSP 2 Score: 137.117 bits (344), Expect = 0.000e+0 Identity = 100/312 (32.05%), Postives = 149/312 (47.76%), Query Frame = 2 Query: 89 FDEEYPGVTICESSMTSGE--------------LGGNHNCTHVEGNLVIQNV--WPDQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQN--------SLALEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL----ITYNKYMEHQCHSDC--------LRNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLR--VGYMCANSCPGS 910 F+ +YP IC S G LG CTH+ GNL I ++ + + DL FL SIIE++G + + NN +K I L NLKVIRG ++ SE +++ +D N LR I + +V ++L +++ W ++ ++P QKL +CH++C +R+ F C+ S N CQKQ+KCVK K +++WC F + GEI C +C GGC+G + DC VC K V + CV C P + G ++ KLR VG +C + CP S Sbjct: 21 FNPDYPNFRICVVSEAHGSFKTPAEAYKYLKYTLGLGQRCTHIYGNLPISDLSRFKNGSDPDLSFLESIIEISGSLSIINNDVKRIPLTNLKVIRGVTLRNEPDALNIIHNHSENGTFLEEIDLRN--------LRAIMSKNVIISQNPGLEYLEKNLDWSQILDDPTTQKLKVSEFVRPSNGTAKCHTECEYWTGEDGVRSQF--CFGPSKNECQKQTKCVKNK--DLKWCKF-TKTGEIP---CSHECAGGCDGRTSKDCTVCNKLVKDSDCVSSCAPRPNHIFG---MDSKDKLRYTVGGLCTSQCPAS 313
BLAST of epidermal growth factor receptor 2 vs. Planmine SMEST
Match: SMESG000005947.1 (SMESG000005947.1) HSP 1 Score: 548.895 bits (1413), Expect = 0.000e+0 Identity = 339/897 (37.79%), Postives = 485/897 (54.07%), Query Frame = 3 Query: 885 CARIRVQEVDACIYSCNSLHFYRVDNKCIRCQNSSVCAXXXXXXXXXXXXXXXDV---FYMTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGDLIIDGSNIVLKNLTFLQNLKEIRHLLTQSASAALNIMH------TDLEFLGLRKLRRIFGKFEVHDSPGLCYADTLNWTGNILKNNQFDPIYPPCN---KPCDSKCDSQGCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYT--NTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYF---SFNKTCIKCHETCMENDKNQPLCTGESSILGLGGCSYCSKLIHKRDEKFYCYKDPCPRHYYLNKIDISEVMKRQKSKEIGICQPCLEPCLECSGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNAS-----------CPYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNKSCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKWSLIILSVITVFLISSVYIFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWK-PSNKD--LEKSDRD-SLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPND 3479 C + + E C++ C+ +F N CI+C ++C N + D FY+ A L + + ++G T SF K IT+ MLY++L +Q + G N LKNLTFL+NL R S L H T+LEFLGL+ L+ I G F + LCY +N N L N + Y P N K C C +GCWGPG+ +CY CR + A CV C + GFY N+S + C RCHP CL C GP P CI GC+ +EN CV +CS+ ++ + +K C+ CH C E N +CTG SS+ G+GGC+ C +++ R C Y D ++ + C PC E C +C G CE C G W + C +C P++ S C C+ +C + C + F C C K++YLD C CP + + DI+C++ + + E K ++++++ + +I V I K ++ LKA YSN+ EP+S+ K PNM RL+++ DLIF +KP+G GAFG VY+G WK P N++ L+K+ D L VA+KVI+ N +I+ +M+EAK+MASV H HCLR IG+CL YE PCLI+ +V+ GSLDK+L ++K+ + S +LSW EQIADGM YL R IIHRDLA RNVL++ LE +QITDFGL+ +++ T+D EI+I G+VPIRWLA+ETL +G YSH+TDVW+FG+TLWEIFT+G+ PY++ +I ++++G RL+QP+ICS+D+Y +M CW E+ N RP F+ LM T + + + P YL+I D Sbjct: 313 CPAMMLPENTGCVHKCSEGYFKNKSNHCIKCY-GNMCTNDHLPCNLFKIAGHTDGANDFYLRAQDLVQLKNCKKILGYIVLTEDSFVKH--NITVEMLYENLNKLQELEGGFSYFKDN-HLKNLTFLRNLLRFRAAYLHSDIPNLPSYHKFAISETELEFLGLKSLKEINGPFRFFKNQKLCY---MNIPVNELFKNVKNFYYIPSNCTDKICHKDCSEKGCWGPGNKLCYECRKYDAAGTCVSDCSQKKGFYNPINSSLLSNQK-------CLRCHPECLNTCVGPNPNQCIKGCKNKRENGTCVASCSKNFYPPLNDSKACLPCHPNCSE--YNSTICTGPSSVPGIGGCNKCERILLSRKADIVSCVKTCHEGTYAFPNDRPDISRFYPVTGF-TCLPCPELCSKCKGKSPKNDECEVCKGVWHKNTCRLRC-------PKDESYGTKIIDSISYCKTCHSSC-KGCYGS--TIFNCTRCKNKKIYLDKKKFYCNDTCPPLKSVEEIEKGSGDIVCLSLWESKAKLEETKRTHITVGVVVTMLILVIIVIVTIVVYLKRKAIAERIETELKARYSNLTEPNSKDEDLLSKP-PNMGRLMIVSKEDLIFEDESKPLGFGAFGYVYKGKWKIPKNEETLLKKASGDFYLPVAIKVIKNMGNEEIESVMQEAKMMASVSHMHCLRFIGVCLSYEKPCLISAYVKEGSLDKFLIRNKNKITSLIMLSWSEQIADGMLYLTKRNIIHRDLAARNVLVSRLECVQITDFGLSKMLESTKD--KEIIIKTGKVPIRWLAIETLTDGKYSHETDVWAFGVTLWEIFTFGKVPYEDQATHDIFDFVLKGGRLSQPDICSLDVYIIMVNCWLESPNLRPDFQNLMQTFTDYCKNPGRYLSIQGD 1179 HSP 2 Score: 148.288 bits (373), Expect = 0.000e+0 Identity = 99/297 (33.33%), Postives = 149/297 (50.17%), Query Frame = 2 Query: 89 FDEEYPGVTIC-------ESSMTSGE------LGGNHNCTHVEGNLVIQNVWP-DQESGDLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSLA---LEKSEVSVYIDLLDEENSQYAIFPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKL----ITYNKYMEHQCHSDC-LRNDFP--YCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGYMCANSCPG 907 F+EEYPG IC ES +S E + + NCTH++G++ I + + + +L F SI E+ G + ++ N ++ I NL++IRG NS+ ++K + + + F LR I ++V F + K K+LP SIKW ELF +PK Q L +T + + +C C L +F +CW SAN CQ+Q+ C + C + NGE ++G C++QC GGCNG S C CK +N CVE C + G T N F+ G+ C+ CP Sbjct: 23 FEEEYPGTIICQNDNVQIESLHSSVEKLKILSIIRSKNCTHIQGSIYILGITKLESKERELNF-DSIEEIDGHLIIEGNDLEKITFKNLRIIRGANSIKRNLIDKGHTDFSLVVSGNAHLVDLDFRSLRSINAHNVIFDSNPKMKYLPHSIKWNELFTDPKAQILFSPTVTKDLILRDKCSDQCKLWANFTQVFCWGPSANQCQQQTLCGSKYSSECTTCRYI--NGE-EQGCCNDQCLGGCNGGGASKCTACKNMLNKKKCVELCRGPYSGGIGGTITNKEFRYHAGFFCSKQCPA 315
BLAST of epidermal growth factor receptor 2 vs. Planmine SMEST
Match: SMESG000070834.1 (SMESG000070834.1) HSP 1 Score: 476.863 bits (1226), Expect = 1.139e-145 Identity = 306/823 (37.18%), Postives = 441/823 (53.58%), Query Frame = 3 Query: 1173 KHLGNVQYITGDLIIDGSNIVLK--NLTFLQNLKEIRHLLTQSASAALNIMHTDLEFLGLRKLRRIFGK------------FEVHDSPGLCYADTLNWTGNILKNNQFDP-IYPPCNKPCDSKCDSQ-GCWGPGSHMCYNCRGFRAVYNCVDRCEDEPGFYTNTSAIKKYTDNYDDGICQRCHPLCLQNCTGPRPTNCIGGCRYFKENDECVKNCSRKYF--SFNKTCIKCHETCMENDKNQ-PLCTGESSILGLGGCSYCSKLIHKRDEKF-YCYKDPCPRHYY-LNKIDISEV----MKRQKSKEIGICQPCLEPCLEC--------SGNYTIYPTCEKCNGYWSGDRCVKQCFPIALNLPRNASC----------PYCNGNCVERCTVTPNDPFQCGSCNFKRLYLDNHNK---SCVSECPQTHKYKHKDGNLTDIICMTRSQWLSYQENPKFISKW--SLIILSVITVFLISSVY-IFFRYVNKINQKKSVKYLKAIYSNIHEPDSRIILQNKKTIPNMNRLLLIPTTDLIFNINTKPIGTGAFGAVYRGVWK------PSNKDLEKSDRDSLDVAVKVIRANRNIDIQEIMEEAKVMASVCHKHCLRLIGICLKYEMPCLITTFVELGSLDKYLRKHKSTLCSRTLLSWGEQIADGMTYLEIRGIIHRDLATRNVLLNDLEIIQITDFGLAHIVQCTEDNKNEIVISGGQVPIRWLALETLLNGIYSHKTDVWSFGITLWEIFTYGERPYDELDVREITSYLIQGNRLAQPEICSVDLYQLMCRCWYENANDRPSFETLMSTLSCFHQFPTCYLNIPN 3476 K L N++ I+G + ID + K +L+FL NL+ I L+ S +L I++T++ +LGL+ L+ I K F++ + DTLN I N DP + C +CDSQ GCWGPG + C +C R C + C +PG+ TN + K +C +CH C + C+G R CIGGC++ EN CV+ CSR +F KTC CH+ C + P+CTG S+ G GGC+ C +I +RD + CY++ Y+ LN + + + + I I +PC + C +C S + T + C +C GYW D+CV C + L + + P CNG C N+ C CN +L +N N SCV CP YK GN + IC+ F+S W +L+IL+V+ +F+I +++ I ++ + N K+ LKA +SN E DS+ + PNMN LL+I + +L F + + +G G FG+VY G WK N + +DV +KV+ N + D E M+E ++MASV HKHCLRLIG+ K LI++++ LGS++KYL K+K +L + LL W EQIA+GM YLE IIHRDLATRNVL+ +QITDFGL+ I+ NK+E+ I GG VP+RWLA+ETL +GIYSHKTDVW++ +TLWEIFT+ PY+ L EI +I+G RL QP+ICS+D+Y LM +CW + +RP+FE L + + YL+ PN Sbjct: 420 KFLENLRNISGSVYIDLKDAPFKLDSLSFLSNLQAIESLVP-IISTSLTIINTNISYLGLKSLKTIKNKAIFFKNNTKLCYFDIKKFKNIVKTDTLNDVTIISDNGMADPKLCEQRGNVCSVQCDSQLGCWGPGPNHCISCANVRLGTICAENCLVQPGYLTNPDSTSK--------VCLKCHDECAKTCSGLRSDQCIGGCKHAMENSMCVRECSRTHFLNKITKTCEPCHKDCHSRSITRLPVCTGPSNTPGPGGCNKCQSMILRRDYQVERCYQNTSLNGYFSLNHPNTNSSPHSNFIEKFTDLIVILEPCHDLCSQCTIGTDQRISLSKTDWKGCTQCKGYWFDDKCVSICPKVRTFLKADETNSSLGKCHPCHPQCNG-----CYGVDNN--HCIHCNNFKL-PENENLTLFSCVESCPSN--YKETSGNSNENICVFV-----------FLSGWELALVILAVVFIFVIITLFTIITKFCHARNGKRKRDKLKAYFSNAKESDSQT-----PSPPNMNHLLVISSDNLEFIMGGEILGKGTFGSVYAGKWKLDNGCFDDNSSMNSCKDSKVDVVIKVL--NHSCDQNEFMDEVRIMASVRHKHCLRLIGVSYKGSEKLLISSYMPLGSMEKYLEKNKKSLTGKILLKWAEQIANGMLYLENNHIIHRDLATRNVLIYKENHVQITDFGLSKIIN---PNKDEMQIFGGMVPVRWLAIETLRDGIYSHKTDVWAYAVTLWEIFTFATVPYEFLKAHEIRDEIIKGTRLRQPDICSLDIYILMLKCWSVDPEERPNFEYLWTEFKNYSNNSETYLSYPN 1202 HSP 2 Score: 122.094 bits (305), Expect = 1.551e-27 Identity = 93/294 (31.63%), Postives = 137/294 (46.60%), Query Frame = 2 Query: 98 EYPGVTICESSM--TSGELGGNHN---------CTHVEGNLVIQNVWPDQESG--DLGFLSSIIEVTGMIFMKNNSIKDIILPNLKVIRGQNSL-------ALEKS-EVSVYIDLLDEENSQYAI-FPKLRVIANNSVYFKTKVKHKFLPQSIKWEELFENPKKQKLITYNKYMEHQCHSDCL-RNDFPYCWSSSANHCQKQSKCVKEKVDNIEWCYFKMRNGEIDEGFCDEQCTGGCNGPKNSDCAVCKKYVNGNHCVEYCPPEFIYDRGNTKLNPNFKLRVGY--MCANSCP 904 EYP + C SSM G N+N CTHV GN+ I NV + DL FLS I E+TG + ++N++I + L NL+VIRG + L AL+ S EVS+ D+ + + I LR I + ++Y ++ +++W EL E+P +Q + +C C+ + +CW + CQ SKC K N C+ DE C+ QC GGC +S C C+ ++ N C CPP+ I +R PN R + +C N CP Sbjct: 37 EYPEIKYCFSSMDLLDGSQSSNYNTLKQDLGNNCTHVYGNIFINNVKSESNGSEPDLEFLSGIKEITGSLKIRNSNISSVPLRNLRVIRGDSRLYTHDSMGALQNSFEVSIDQDISVSNSIKTVIDLRSLRSIVSGNIYISSQFCSSL--ANVEWNELLEDPTRQSVTGKCTPQPTKCSKKCMQKGKSGFCWGPLTSQCQIFSKCRKRMCAN--RCFLSETG---DEECCNSQCLGGCTSSDSSSCIACQGVLDNNVCQPECPPKKIINRETGIPEPNKYFRPLFVNICLNKCP 323 The following BLAST results are available for this feature:
BLAST of epidermal growth factor receptor 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of epidermal growth factor receptor 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029442 ID=SMED30029442|Name=epidermal growth factor receptor 2|organism=Schmidtea mediterranea sexual|type=transcript|length=3956bpback to top protein sequence of SMED30029442-orf-1 >SMED30029442-orf-1 ID=SMED30029442-orf-1|Name=SMED30029442-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=104bp MSFDTEYIYCRLDRNEDYCSCICKHQLPGHEFAHIYPTLNLKFGFNFVFPback to top protein sequence of SMED30029442-orf-2 >SMED30029442-orf-2 ID=SMED30029442-orf-2|Name=SMED30029442-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=304bp INEVRLLMGFVCNIIVVIILLESSLAIRQFDEEYPGVTICESSMTSGELGback to top protein sequence of SMED30029442-orf-3 >SMED30029442-orf-3 ID=SMED30029442-orf-3|Name=SMED30029442-orf-3|organism=Schmidtea mediterranea sexual|type=polypeptide|length=933bp MTAAILKNFTDIEHVIGEFHFTAQSFDKALGGITLPMLYKHLGNVQYITGback to top Aliases
The feature 'epidermal growth factor receptor 2' has the following synonyms
Annotated Terms
The following terms have been associated with this transcript:
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