Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029410 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Human
Match: PTEN (phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588]) HSP 1 Score: 252.292 bits (643), Expect = 3.800e-76 Identity = 149/379 (39.31%), Postives = 210/379 (55.41%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L Y L + ++ + +P+ SG QFV+ QLKV S + + + + V D+K +F K +K KK+ + H W+NTFFI P + + +++ S ++ E + S ++D+D + + L L K+++DKA KD N+ F F + F
Sbjct: 1 MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC-------QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFI---PGPEETSEKVENGSLCDQ------------------EIDSICSIERADNDKEYLV--LTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Human
Match: PTEN (phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588]) HSP 1 Score: 253.832 bits (647), Expect = 8.388e-75 Identity = 148/375 (39.47%), Postives = 209/375 (55.73%), Query Frame = 3
Query: 120 LKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
+KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L Y L + ++ + +P+ SG QFV+ QLKV S + + + + V D+K +F K +K KK+ + H W+NTFFI P + + +++ S ++ E + S ++D+D + + L L K+++DKA KD N+ F F + F
Sbjct: 178 IKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC-------QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFI---PGPEETSEKVENGSLCDQ------------------EIDSICSIERADNDKEYLV--LTLTKNDLDKANKDKANRYFSPNFKVKLYF 520
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Human
Match: PTEN (phosphatase and tensin homolog [Source:HGNC Symbol;Acc:HGNC:9588]) HSP 1 Score: 253.832 bits (647), Expect = 8.388e-75 Identity = 148/375 (39.47%), Postives = 209/375 (55.73%), Query Frame = 3
Query: 120 LKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
+KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L Y L + ++ + +P+ SG QFV+ QLKV S + + + + V D+K +F K +K KK+ + H W+NTFFI P + + +++ S ++ E + S ++D+D + + L L K+++DKA KD N+ F F + F
Sbjct: 178 IKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC-------QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFI---PGPEETSEKVENGSLCDQ------------------EIDSICSIERADNDKEYLV--LTLTKNDLDKANKDKANRYFSPNFKVKLYF 520
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Human
Match: TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:HGNC Symbol;Acc:HGNC:17299]) HSP 1 Score: 177.178 bits (448), Expect = 4.065e-49 Identity = 86/181 (47.51%), Postives = 120/181 (66.30%), Query Frame = 3
Query: 120 LKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNG-----KGVTIPSQIRFIYYF 647
++ LVS+ K RY +DGFDLDL+Y+T RIIAM FP+ + YRN I++VV F KKH NHY++YNLC+ER D + F HN ++ + +DHN P +M+ KE+ +++ D NIVAI CK GKGRTG +VCA L++ E +A + L ++GERRT +GV PSQ R++ YF
Sbjct: 70 MRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHF-HNRVS-RIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYF 248
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Human
Match: TPTE2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:HGNC Symbol;Acc:HGNC:17299]) HSP 1 Score: 176.022 bits (445), Expect = 6.892e-48 Identity = 86/181 (47.51%), Postives = 120/181 (66.30%), Query Frame = 3
Query: 120 LKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNG-----KGVTIPSQIRFIYYF 647
++ LVS+ K RY +DGFDLDL+Y+T RIIAM FP+ + YRN I++VV F KKH NHY++YNLC+ER D + F HN ++ + +DHN P +M+ KE+ +++ D NIVAI CK GKGRTG +VCA L++ E +A + L ++GERRT +GV PSQ R++ YF
Sbjct: 90 MRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHF-HNRVS-RIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYF 268
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Celegans
Match: daf-18 (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 [Source:UniProtKB/Swiss-Prot;Acc:G5EE01]) HSP 1 Score: 145.976 bits (367), Expect = 7.826e-36 Identity = 78/216 (36.11%), Postives = 118/216 (54.63%), Query Frame = 3
Query: 120 LKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHA-NHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVI 764
+ VS + R DLD +YIT RIIA+G+PA E +RN F ++H + +++NL + D F+ N I + DH+PP M C+E +++L++D +++A+ CKAGKGRTGV++CA L+ S IL +Y RT N KGVTIPSQ R+IYY+ +EL Y ++L V ++ P G G +I+ +
Sbjct: 49 FRTAVSSNRCRTEYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYYYDADNFDGNVIC--FDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRERELNYLPLRMQLIGVYVERPPKTWGGGSKIKVEV 262
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Celegans
Match: tns-1 (TeNSin homolog [Source:UniProtKB/TrEMBL;Acc:H2L045]) HSP 1 Score: 55.8398 bits (133), Expect = 1.236e-7 Identity = 65/292 (22.26%), Postives = 119/292 (40.75%), Query Frame = 3
Query: 126 ELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACL---LSQEPDKSATD--ILQFYGER-RTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDR-----EAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLC--HCWLNT 962
+L K+K++ ++G ++ YITSR+I + +++ E + + H H +++N+ RH + +I +P P ++ CK + ++ P NI I CK G R ++V A + D S D +Q + ER +G PS R++ YF L + L L++++L I + IY+R ++K + ++ +S+F DG+ L D+ F+ I+ + C C LNT
Sbjct: 31 QLRLKQKMKDRKEGVQVE--YITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNVSQRRHDISSSLD--AIPFGWP--SETAPSLEKLCTICKNLDQWMLEHPLNIAVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERFLGPDGP----PSYKRYLGYFSSLLSGRISVNSDPLYLHNIILTFF-------EPINVFLKIYERLVPVYQSKTVALNKSSKF---EMDGSLKLR----------GDIFFKCIVAASSPGSSTRCLFTCQLNT 292
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Celegans
Match: tns-1 (TeNSin homolog [Source:UniProtKB/TrEMBL;Acc:H2L045]) HSP 1 Score: 53.5286 bits (127), Expect = 5.359e-7 Identity = 61/276 (22.10%), Postives = 109/276 (39.49%), Query Frame = 3
Query: 174 LDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACL---LSQEPDKSATD--ILQFYGER-RTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDR-----EAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLC--HCWLNT 962
+ + YITSR+I + +++ E + + H H +++N+ RH + +I +P P ++ CK + ++ P NI I CK G R ++V A + D S D +Q + ER +G PS R++ YF L + L L++++L I + IY+R ++K + ++ +S+F DG+ L D+ F+ I+ + C C LNT
Sbjct: 8 VQVEYITSRLIVLSCTSETSERKFVESLLKASQQIQNAHNKHIRVWNVSQRRHDISSSLD--AIPFGWP--SETAPSLEKLCTICKNLDQWMLEHPLNIAVIFCKGGLERCAIVVNAFMRFNAISATDDSVDDRFSMQRFSERFLGPDGP----PSYKRYLGYFSSLLSGRISVNSDPLYLHNIILTFF-------EPINVFLKIYERLVPVYQSKTVALNKSSKF---EMDGSLKLR----------GDIFFKCIVAASSPGSSTRCLFTCQLNT 255
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0089902) HSP 1 Score: 217.624 bits (553), Expect = 2.587e-63 Identity = 134/395 (33.92%), Postives = 194/395 (49.11%), Query Frame = 3
Query: 105 IMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPA-QSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFI--------VSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENYHFNN 1262
+M N ++ +VSKK+IRY + G+DLDL+YI IIAMG+PA EG++RN ++DV + HA HY+IYNLC+ER D KF YPF+DHNPP + C ++ +L D +N+VA+ CKAGKGRTG ++CA L+ KSA + L +Y E+RT + KGVTIPSQ R++ YF + + Y K L + + E + G + V H S A+ D ++L + + F+ VS D+KF+ KS + +CH WLNTFF+ ++S +SD +++ L K EID KD +K F F I+ VFE +F+N
Sbjct: 7 LMSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVA--VYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGM-----------VECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKS---PDKIICHFWLNTFFV------------------------------------------RNYSPCESDGTVNKYIHT--LSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSN 341
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0089905) HSP 1 Score: 218.394 bits (555), Expect = 1.193e-62 Identity = 134/395 (33.92%), Postives = 194/395 (49.11%), Query Frame = 3
Query: 105 IMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPA-QSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFI--------VSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENYHFNN 1262
+M N ++ +VSKK+IRY + G+DLDL+YI IIAMG+PA EG++RN ++DV + HA HY+IYNLC+ER D KF YPF+DHNPP + C ++ +L D +N+VA+ CKAGKGRTG ++CA L+ KSA + L +Y E+RT + KGVTIPSQ R++ YF + + Y K L + + E + G + V H S A+ D ++L + + F+ VS D+KF+ KS + +CH WLNTFF+ ++S +SD +++ L K EID KD +K F F I+ VFE +F+N
Sbjct: 7 LMSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVA--VYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGM-----------VECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKS---PDKIICHFWLNTFFV------------------------------------------RNYSPCESDGTVNKYIHT--LSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSN 341
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0089901) HSP 1 Score: 218.394 bits (555), Expect = 1.193e-62 Identity = 134/395 (33.92%), Postives = 194/395 (49.11%), Query Frame = 3
Query: 105 IMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPA-QSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFI--------VSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENYHFNN 1262
+M N ++ +VSKK+IRY + G+DLDL+YI IIAMG+PA EG++RN ++DV + HA HY+IYNLC+ER D KF YPF+DHNPP + C ++ +L D +N+VA+ CKAGKGRTG ++CA L+ KSA + L +Y E+RT + KGVTIPSQ R++ YF + + Y K L + + E + G + V H S A+ D ++L + + F+ VS D+KF+ KS + +CH WLNTFF+ ++S +SD +++ L K EID KD +K F F I+ VFE +F+N
Sbjct: 7 LMSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVA--VYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGM-----------VECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKS---PDKIICHFWLNTFFV------------------------------------------RNYSPCESDGTVNKYIHT--LSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSN 341
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0300562) HSP 1 Score: 218.394 bits (555), Expect = 1.478e-62 Identity = 134/395 (33.92%), Postives = 194/395 (49.11%), Query Frame = 3
Query: 105 IMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPA-QSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFI--------VSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENYHFNN 1262
+M N ++ +VSKK+IRY + G+DLDL+YI IIAMG+PA EG++RN ++DV + HA HY+IYNLC+ER D KF YPF+DHNPP + C ++ +L D +N+VA+ CKAGKGRTG ++CA L+ KSA + L +Y E+RT + KGVTIPSQ R++ YF + + Y K L + + E + G + V H S A+ D ++L + + F+ VS D+KF+ KS + +CH WLNTFF+ ++S +SD +++ L K EID KD +K F F I+ VFE +F+N
Sbjct: 7 LMSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVA--VYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGM-----------VECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKS---PDKIICHFWLNTFFV------------------------------------------RNYSPCESDGTVNKYIHT--LSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSN 341
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Fly
Match: Pten (gene:FBgn0026379 transcript:FBtr0301521) HSP 1 Score: 218.394 bits (555), Expect = 1.478e-62 Identity = 134/395 (33.92%), Postives = 194/395 (49.11%), Query Frame = 3
Query: 105 IMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPA-QSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFI--------VSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENYHFNN 1262
+M N ++ +VSKK+IRY + G+DLDL+YI IIAMG+PA EG++RN ++DV + HA HY+IYNLC+ER D KF YPF+DHNPP + C ++ +L D +N+VA+ CKAGKGRTG ++CA L+ KSA + L +Y E+RT + KGVTIPSQ R++ YF + + Y K L + + E + G + V H S A+ D ++L + + F+ VS D+KF+ KS + +CH WLNTFF+ ++S +SD +++ L K EID KD +K F F I+ VFE +F+N
Sbjct: 7 LMSNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVA--VYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSSVPYSKVSLNVCEIRFSESSCVQNLGM-----------VECSISVLHDSATENAKPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKS---PDKIICHFWLNTFFV------------------------------------------RNYSPCESDGTVNKYIHT--LSKSEIDDVHKDSEHKRFSEEFKISIVFEAENFSN 341
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Zebrafish
Match: ptena (phosphatase and tensin homolog A [Source:ZFIN;Acc:ZDB-GENE-030131-3776]) HSP 1 Score: 278.485 bits (711), Expect = 5.853e-86 Identity = 160/388 (41.24%), Postives = 220/388 (56.70%), Query Frame = 3
Query: 102 IIMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKV------GKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
+ M KLKE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R++YY+ + L+ +L Y+ L + +V +P+ SG QFV+Y QLKV HTS R++ + + + V D+K +F K SK KK+ + H W+NTFFI P + D +++ S N V +S+ + R + D + +D + L L K+++DKA KD N+ F F + F
Sbjct: 1 MAMTAKLKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDASKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNKLDYKPVALLFHKMVFQTLPMFSGGTCNPQFVVY-------QLKVKIHTSNPAHTRRE-EKHMIFEFPQPLPVCGDIKVEFFHKQSKMMKKDKMFHFWINTFFI---PGPEEAGDKVENGSVVNDVDSLSCQSQSSPAERDREKERAVAAAALDRERGEQRADGEKDYLILTLTKNDLDKANKDKANRYFSPNFKVKLYF 375
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Zebrafish
Match: ptena (phosphatase and tensin homolog A [Source:ZFIN;Acc:ZDB-GENE-030131-3776]) HSP 1 Score: 271.937 bits (694), Expect = 7.910e-84 Identity = 158/380 (41.58%), Postives = 212/380 (55.79%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M KLKE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R++YY+ + L+ +L Y+ L + +V +P+ SG QFV+Y QLKV HTS R++ + + + V D+K +F K SK KK+ + H W+NTFFI P + D +++ S N V K +D + L L K+++DKA KD N+ F F + F
Sbjct: 1 MTAKLKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDASKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNKLDYKPVALLFHKMVFQTLPMFSGGTCNPQFVVY-------QLKVKIHTSNPAHTRRE-EKHMIFEFPQPLPVCGDIKVEFFHKQSKMMKKDKMFHFWINTFFI---PGPEEAGDKVENGSVVNDVDKQR-------------------------ADGEKDYLILTLTKNDLDKANKDKANRYFSPNFKVKLYF 342
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Zebrafish
Match: ptena (phosphatase and tensin homolog A [Source:ZFIN;Acc:ZDB-GENE-030131-3776]) HSP 1 Score: 271.937 bits (694), Expect = 7.910e-84 Identity = 158/380 (41.58%), Postives = 212/380 (55.79%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M KLKE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R++YY+ + L+ +L Y+ L + +V +P+ SG QFV+Y QLKV HTS R++ + + + V D+K +F K SK KK+ + H W+NTFFI P + D +++ S N V K +D + L L K+++DKA KD N+ F F + F
Sbjct: 1 MTAKLKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDASKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNKLDYKPVALLFHKMVFQTLPMFSGGTCNPQFVVY-------QLKVKIHTSNPAHTRRE-EKHMIFEFPQPLPVCGDIKVEFFHKQSKMMKKDKMFHFWINTFFI---PGPEEAGDKVENGSVVNDVDKQR-------------------------ADGEKDYLILTLTKNDLDKANKDKANRYFSPNFKVKLYF 342
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Zebrafish
Match: ptena (phosphatase and tensin homolog A [Source:ZFIN;Acc:ZDB-GENE-030131-3776]) HSP 1 Score: 268.855 bits (686), Expect = 4.934e-82 Identity = 160/401 (39.90%), Postives = 220/401 (54.86%), Query Frame = 3
Query: 102 IIMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKK-------------ENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKV------GKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
+ M KLKE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R++YY+ + L+ +L Y+ L + +V +P+ SG QFV+Y QLKV HTS R++ + + + V D+K +F K SK KK + + H W+NTFFI P + D +++ S N V +S+ + R + D + +D + L L K+++DKA KD N+ F F + F
Sbjct: 1 MAMTAKLKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDASKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNKLDYKPVALLFHKMVFQTLPMFSGGTCNPQFVVY-------QLKVKIHTSNPAHTRRE-EKHMIFEFPQPLPVCGDIKVEFFHKQSKMMKKVCLTRLDLLHKPLDKMFHFWINTFFI---PGPEEAGDKVENGSVVNDVDSLSCQSQSSPAERDREKERAVAAAALDRERGEQRADGEKDYLILTLTKNDLDKANKDKANRYFSPNFKVKLYF 388
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Zebrafish
Match: ptena (phosphatase and tensin homolog A [Source:ZFIN;Acc:ZDB-GENE-030131-3776]) HSP 1 Score: 268.47 bits (685), Expect = 8.864e-82 Identity = 160/411 (38.93%), Postives = 222/411 (54.01%), Query Frame = 3
Query: 102 IIMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNG-----------------------YEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKV------GKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
+ M KLKE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R++YY+ + L+ +L Y+ L + +V +P+ SG ++ QFV+Y QLKV HTS R++ + + + V D+K +F K SK KK+ + H W+NTFFI P + D +++ S N V +S+ + R + D + +D + L L K+++DKA KD N+ F F + F
Sbjct: 1 MAMTAKLKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDASKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNKLDYKPVALLFHKMVFQTLPMFSGGTCRDSTVKNRSEVNPQGFKKGSWHWDPQFVVY-------QLKVKIHTSNPAHTRRE-EKHMIFEFPQPLPVCGDIKVEFFHKQSKMMKKDKMFHFWINTFFI---PGPEEAGDKVENGSVVNDVDSLSCQSQSSPAERDREKERAVAAAALDRERGEQRADGEKDYLILTLTKNDLDKANKDKANRYFSPNFKVKLYF 398
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Xenopus
Match: pten (phosphatase and tensin homolog [Source:NCBI gene;Acc:100144716]) HSP 1 Score: 254.988 bits (650), Expect = 3.680e-77 Identity = 154/382 (40.31%), Postives = 212/382 (55.50%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLS---DECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF QYPF DHNPP + C+++ +L S+ N+ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L+Y L + + + +P+ SG+ QFV+Y QLKV + + + R L+ + V D+K +F K +K KKE + H W+NTFFI P + + + ++ N VG+ E +S +SD+D + L L K+++DKA KD N+ F F + F
Sbjct: 1 MTAIIKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTNKFSCRVA--QYPFEDHNPPQLELIKPFCEDLDQWL-SENENVAAIHCKAGKGRTGVMICAYLLHRGKFPRAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNNLEYRPVPLLFHKIEFETIPMFSGSTCNPQFVVY-------QLKV----KIFTSTAGPKRIEKLMYFDFPQPLPVCGDIKVEFFHKQNKVMKKEKMFHFWINTFFI---PGPEEYSEKVE---NGTLVGEQ--------------ELDGIYSTERSDNDKE--YLTLTLTKNDLDKANKDKANRLFSPNFKVKLFF 346
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Xenopus
Match: pten (phosphatase and tensin homolog [Source:NCBI gene;Acc:100144716]) HSP 1 Score: 204.142 bits (518), Expect = 1.301e-58 Identity = 135/376 (35.90%), Postives = 190/376 (50.53%), Query Frame = 3
Query: 120 LKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
+KE VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDV YPF DHNPP + C+++ +L S+ N+ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L+Y L + + + +P+ SG+ QFV+Y QLKV TS R + + + V D+K +F K +K KKE + H W+NTFFI P + + + ++ N VG+ E +S +SD+D + L L K+++DKA KD N+ F F + F
Sbjct: 5 IKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDV------------------------------------YPFEDHNPPQLELIKPFCEDLDQWL-SENENVAAIHCKAGKGRTGVMICAYLLHRGKFPRAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNNLEYRPVPLLFHKIEFETIPMFSGSTCNPQFVVY-------QLKVKIFTSTAGPKRIEKLMYFDF--PQPLPVCGDIKVEFFHKQNKVMKKEKMFHFWINTFFI---PGPEEYSEKVE---NGTLVGEQ--------------ELDGIYSTERSDNDKE--YLTLTLTKNDLDKANKDKANRLFSPNFKVKLFF 312
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Xenopus
Match: tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:NCBI gene;Acc:548705]) HSP 1 Score: 176.792 bits (447), Expect = 7.132e-48 Identity = 109/298 (36.58%), Postives = 166/298 (55.70%), Query Frame = 3
Query: 123 KELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRT-----TNGKGVTIPSQIRFIYYFEHF---LRKELKYEKTVLKLNHVVLDEMPIIS-GNGYEIQFVIYIYDREAKQLKVHHTSQ----FYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLC--HCWLNTFFI 971
+ LVS+ K RY +DGFDLDL+YIT RIIAM FP+ + YRN I++V F KH +HY+IYNLC+E+ D + F H + + +DHN P+ M+ ++ ++ DP N++AI CK GKGRTG +VC L+ + +SA + L ++GERRT T +GV PSQ R++ Y+E ++L EK LK+ + + + + NG +++ I I +E V T F++A G S+ + D C ++S D+K +F + K + C + W NT FI
Sbjct: 125 RRLVSENKRRYQKDGFDLDLTYITDRIIAMSFPSSGKQSFYRNPIEEVARFLDSKHQDHYKIYNLCSEKGYDPKYF-HYRVERVF-IDDHNVPVLADMLTFTASVRAWMAEDPQNVIAIHCKGGKGRTGTMVCTYLVDSDQFESAVESLDYFGERRTDTSVSTKFQGVETPSQSRYVAYYEVLKNKFSRQLPPEKQ-LKIRSIRIYSIQGVGRSNGTDLKVQI-IMKKEVVFQCVCETQGNCKLFFDA---GNNSIVISLDGCPVISGDIKIRFESSANIPKGYDDCAFYFWFNTSFI 415
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Xenopus
Match: tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:NCBI gene;Acc:548705]) HSP 1 Score: 177.563 bits (449), Expect = 1.436e-47 Identity = 109/298 (36.58%), Postives = 166/298 (55.70%), Query Frame = 3
Query: 123 KELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRT-----TNGKGVTIPSQIRFIYYFEHF---LRKELKYEKTVLKLNHVVLDEMPIIS-GNGYEIQFVIYIYDREAKQLKVHHTSQ----FYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLC--HCWLNTFFI 971
+ LVS+ K RY +DGFDLDL+YIT RIIAM FP+ + YRN I++V F KH +HY+IYNLC+E+ D + F H + + +DHN P+ M+ ++ ++ DP N++AI CK GKGRTG +VC L+ + +SA + L ++GERRT T +GV PSQ R++ Y+E ++L EK LK+ + + + + NG +++ I I +E V T F++A G S+ + D C ++S D+K +F + K + C + W NT FI
Sbjct: 183 RRLVSENKRRYQKDGFDLDLTYITDRIIAMSFPSSGKQSFYRNPIEEVARFLDSKHQDHYKIYNLCSEKGYDPKYF-HYRVERVF-IDDHNVPVLADMLTFTASVRAWMAEDPQNVIAIHCKGGKGRTGTMVCTYLVDSDQFESAVESLDYFGERRTDTSVSTKFQGVETPSQSRYVAYYEVLKNKFSRQLPPEKQ-LKIRSIRIYSIQGVGRSNGTDLKVQI-IMKKEVVFQCVCETQGNCKLFFDA---GNNSIVISLDGCPVISGDIKIRFESSANIPKGYDDCAFYFWFNTSFI 473
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Xenopus
Match: tpte2 (transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 [Source:NCBI gene;Acc:548705]) HSP 1 Score: 176.407 bits (446), Expect = 1.844e-47 Identity = 109/298 (36.58%), Postives = 166/298 (55.70%), Query Frame = 3
Query: 123 KELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRT-----TNGKGVTIPSQIRFIYYFEHF---LRKELKYEKTVLKLNHVVLDEMPIIS-GNGYEIQFVIYIYDREAKQLKVHHTSQ----FYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLC--HCWLNTFFI 971
+ LVS+ K RY +DGFDLDL+YIT RIIAM FP+ + YRN I++V F KH +HY+IYNLC+E+ D + F H + + +DHN P+ M+ ++ ++ DP N++AI CK GKGRTG +VC L+ + +SA + L ++GERRT T +GV PSQ R++ Y+E ++L EK LK+ + + + + NG +++ I I +E V T F++A G S+ + D C ++S D+K +F + K + C + W NT FI
Sbjct: 146 RRLVSENKRRYQKDGFDLDLTYITDRIIAMSFPSSGKQSFYRNPIEEVARFLDSKHQDHYKIYNLCSEKGYDPKYF-HYRVERVF-IDDHNVPVLADMLTFTASVRAWMAEDPQNVIAIHCKGGKGRTGTMVCTYLVDSDQFESAVESLDYFGERRTDTSVSTKFQGVETPSQSRYVAYYEVLKNKFSRQLPPEKQ-LKIRSIRIYSIQGVGRSNGTDLKVQI-IMKKEVVFQCVCETQGNCKLFFDA---GNNSIVISLDGCPVISGDIKIRFESSANIPKGYDDCAFYFWFNTSFI 436
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Mouse
Match: Pten (phosphatase and tensin homolog [Source:MGI Symbol;Acc:MGI:109583]) HSP 1 Score: 252.292 bits (643), Expect = 2.350e-76 Identity = 149/379 (39.31%), Postives = 210/379 (55.41%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L Y L + ++ + +P+ SG QFV+ QLKV S + + + + V D+K +F K +K KK+ + H W+NTFFI P + + +++ S ++ E + S ++D+D + + L L K+++DKA KD N+ F F + F
Sbjct: 1 MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC-------QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFI---PGPEETSEKVENGSLCDQ------------------EIDSICSIERADNDKEYLV--LTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Mouse
Match: Tpte (transmembrane phosphatase with tensin homology [Source:MGI Symbol;Acc:MGI:2446460]) HSP 1 Score: 186.037 bits (471), Expect = 3.827e-50 Identity = 94/228 (41.23%), Postives = 137/228 (60.09%), Query Frame = 3
Query: 123 KELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNG-----KGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIIS--------GNGYEIQFVIY 767
++LVS K RY +DGFDLDL+Y+T RIIAM FP+ E YRN I +VV F KH NHYQ+YNLC+ER D + F + + +DHN P +M+ KE+ +++ DP N+VAI CK GKGRTG +VCACL++ E +A + L F+GERRT +G+ PSQ R++ YFE ++ Y+ T+ +V+ + + S G+ E+Q +++
Sbjct: 340 RKLVSGNKRRYKKDGFDLDLTYVTERIIAMSFPSSGRESFYRNPIKEVVRFLDTKHPNHYQVYNLCSERAYDPKHFHYRV--RRIMIDDHNVPTLEEMLLFSKEVNNWMAQDPENVVAIHCKGGKGRTGTMVCACLIASEIVLNAKESLYFFGERRTDKSNSSKFQGIETPSQNRYVKYFEKL---KINYQLTLPPKKVLVIKRLVVYSIHGVGKGDGSDLEVQIIMW 562
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Mouse
Match: Tpte (transmembrane phosphatase with tensin homology [Source:MGI Symbol;Acc:MGI:2446460]) HSP 1 Score: 185.652 bits (470), Expect = 1.586e-49 Identity = 110/297 (37.04%), Postives = 164/297 (55.22%), Query Frame = 3
Query: 123 KELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNG-----KGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIIS------GNGYEIQFVIYIYDREAKQL-KVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLC--HCWLNTFFI 971
++LVS K RY +DGFDLDL+Y+T RIIAM FP+ E YRN I +VV F KH NHYQ+YNLC+ER D + F + + +DHN P +M+ KE+ +++ DP N+VAI CK GKGRTG +VCACL++ E +A + L F+GERRT +G+ PSQ R++ YFE ++ Y+ T+ +V+ + + S G+G +++ I ++ + F++ D A +N+ C + DD+K +F L K + C W +T FI
Sbjct: 340 RKLVSGNKRRYKKDGFDLDLTYVTERIIAMSFPSSGRESFYRNPIKEVVRFLDTKHPNHYQVYNLCSERAYDPKHFHYRV--RRIMIDDHNVPTLEEMLLFSKEVNNWMAQDPENVVAIHCKGGKGRTGTMVCACLIASEIVLNAKESLYFFGERRTDKSNSSKFQGIETPSQNRYVKYFEKL---KINYQLTLPPKKVLVIKRLVVYSIHGVGKGDGSDLEVQIIMWQETVFSFCNSRNCMIFHDPETDRA-IINVF--HCPALYDDVKVKF-LSPNLPKYYDDCPFFFWFHTSFI 627
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Mouse
Match: Tns1 (tensin 1 [Source:MGI Symbol;Acc:MGI:104552]) HSP 1 Score: 111.309 bits (277), Expect = 1.858e-24 Identity = 62/200 (31.00%), Postives = 103/200 (51.50%), Query Frame = 3
Query: 150 RYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTI--PSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNG 743
R ++D +LDL Y+T RIIA+ FP+ + E +R+++ +V KH +Y ++NL +R D K + +P D + P ++ CK + +L++DP+N+V + K +GR GV++ A L SA L + +R K V I PSQ R+++YF L +K L L+HV++ +P G
Sbjct: 176 RAMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSEQRP-DITKLHAKVLEFGWP--DLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYLHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKG 372
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Mouse
Match: Tns1 (tensin 1 [Source:MGI Symbol;Acc:MGI:104552]) HSP 1 Score: 111.309 bits (277), Expect = 1.937e-24 Identity = 62/200 (31.00%), Postives = 103/200 (51.50%), Query Frame = 3
Query: 150 RYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTI--PSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNG 743
R ++D +LDL Y+T RIIA+ FP+ + E +R+++ +V KH +Y ++NL +R D K + +P D + P ++ CK + +L++DP+N+V + K +GR GV++ A L SA L + +R K V I PSQ R+++YF L +K L L+HV++ +P G
Sbjct: 176 RAMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNLSEQRP-DITKLHAKVLEFGWP--DLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRGRIGVVIAAYLHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHHVIMHGIPNFESKG 372
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. UniProt/SwissProt
Match: sp|Q9PUT6|PTEN_XENLA (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Xenopus laevis OX=8355 GN=pten PE=2 SV=1) HSP 1 Score: 256.144 bits (653), Expect = 6.493e-77 Identity = 155/382 (40.58%), Postives = 213/382 (55.76%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLS---DECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF QYPF DHNPP + C+++ D L S+ N+ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L+Y L + + + +P+ SG+ QFV+Y QLKV + + + R+ L+ + V D+K +F K +K KKE + H W+NTFFI P + + + ++ N VG+ E +S +SD+D + L L K+++DKA KD N+ F F + F
Sbjct: 1 MTAIIKEFVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTNKFSCRVA--QYPFEDHNPPQLELIKPFCEDL-DQLLSENENVAAIHCKAGKGRTGVMICAYLLHRGKFPRAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNSLEYRPVPLLFHKIEFETIPMFSGSTCNPQFVVY-------QLKV----KIFTSTAGPKRAEKLMYFDFPQPLPVCGDIKVEFFHKQNKVMKKEKMFHFWVNTFFI---PGPEEYSEKVE---NGTLVGEQ--------------ELDGIYSTERSDNDKE--YLTLALTKNDLDKANKDKANRLFSPNFKVKLFF 346
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. UniProt/SwissProt
Match: sp|O08586|PTEN_MOUSE (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Mus musculus OX=10090 GN=Pten PE=1 SV=1) HSP 1 Score: 252.292 bits (643), Expect = 1.644e-75 Identity = 149/379 (39.31%), Postives = 210/379 (55.41%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L Y L + ++ + +P+ SG QFV+ QLKV S + + + + V D+K +F K +K KK+ + H W+NTFFI P + + +++ S ++ E + S ++D+D + + L L K+++DKA KD N+ F F + F
Sbjct: 1 MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC-------QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFI---PGPEETSEKVENGSLCDQ------------------EIDSICSIERADNDKEYLV--LTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. UniProt/SwissProt
Match: sp|P60484|PTEN_HUMAN (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens OX=9606 GN=PTEN PE=1 SV=1) HSP 1 Score: 252.292 bits (643), Expect = 1.825e-75 Identity = 149/379 (39.31%), Postives = 210/379 (55.41%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L Y L + ++ + +P+ SG QFV+ QLKV S + + + + V D+K +F K +K KK+ + H W+NTFFI P + + +++ S ++ E + S ++D+D + + L L K+++DKA KD N+ F F + F
Sbjct: 1 MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC-------QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFI---PGPEETSEKVENGSLCDQ------------------EIDSICSIERADNDKEYLV--LTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. UniProt/SwissProt
Match: sp|P60483|PTEN_CANLF (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Canis lupus familiaris OX=9615 GN=PTEN PE=2 SV=1) HSP 1 Score: 252.292 bits (643), Expect = 1.825e-75 Identity = 149/379 (39.31%), Postives = 210/379 (55.41%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ L Y L + ++ + +P+ SG QFV+ QLKV S + + + + V D+K +F K +K KK+ + H W+NTFFI P + + +++ S ++ E + S ++D+D + + L L K+++DKA KD N+ F F + F
Sbjct: 1 MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVC-------QLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFI---PGPEETSEKVENGSLCDQ------------------EIDSICSIERADNDKEYLV--LTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. UniProt/SwissProt
Match: sp|Q8T9S7|PTEN_DICDI (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Dictyostelium discoideum OX=44689 GN=pteN PE=2 SV=1) HSP 1 Score: 195.667 bits (496), Expect = 4.293e-53 Identity = 97/221 (43.89%), Postives = 141/221 (63.80%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYI 770
M N L+ VSK+K RY ++G+DLDL+YIT I+AMGFP++ EG++RN + DV F + H +H+++YNLC+ER D KF + + + YPF+DHN P F + C+++ ++ D NI I CKAGKGRTG+++C L+ K+ D L+FY RT N KGVTIPSQIR++ YF +R+ +KY + L +VL +P N E+QF I +
Sbjct: 1 MSNLLRVAVSKQKRRYQKNGYDLDLAYITDNIVAMGFPSEKVEGVFRNPMKDVQRFLDQYHKDHFKVYNLCSERVYDHSKF-YGRVGY-YPFDDHNAPQFEMIDAFCRDVDAWMKEDSKNIAVIHCKAGKGRTGLMICCWLMYCGMWKNTEDSLRFYAALRTYNQKGVTIPSQIRYVGYFGRSIRESIKYVPRNVTLKKIVLRPLP-KEINLSEVQFNISV 218
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. TrEMBL
Match: Q6TGR7 (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Danio rerio OX=7955 GN=ptena PE=2 SV=1) HSP 1 Score: 278.485 bits (711), Expect = 1.310e-82 Identity = 160/388 (41.24%), Postives = 220/388 (56.70%), Query Frame = 3
Query: 102 IIMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKV------GKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
+ M KLKE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R++YY+ + L+ +L Y+ L + +V +P+ SG QFV+Y QLKV HTS R++ + + + V D+K +F K SK KK+ + H W+NTFFI P + D +++ S N V +S+ + R + D + +D + L L K+++DKA KD N+ F F + F
Sbjct: 1 MAMTAKLKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDASKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNKLDYKPVALLFHKMVFQTLPMFSGGTCNPQFVVY-------QLKVKIHTSNPAHTRRE-EKHMIFEFPQPLPVCGDIKVEFFHKQSKMMKKDKMFHFWINTFFI---PGPEEAGDKVENGSVVNDVDSLSCQSQSSPAERDREKERAVAAAALDRERGEQRADGEKDYLILTLTKNDLDKANKDKANRYFSPNFKVKLYF 375
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. TrEMBL
Match: A0A3S6CXE8 (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Epinephelus coioides OX=94232 PE=2 SV=1) HSP 1 Score: 277.33 bits (708), Expect = 3.346e-82 Identity = 158/381 (41.47%), Postives = 222/381 (58.27%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQI-QSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M + LKE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ +L+Y+ L + +V + +P+ SG QFV+Y QLKV HTS R++ + + + V D+K +F K +K KK+ + H W+NTFFI + ++G +N++S + + G+ P+ S E + + +SD L L K+++DKA KD N+ F F + F
Sbjct: 1 MASLLKEMVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDAAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNQLEYKPVALLFHKMVFETLPMFSGGTCNPQFVVY-------QLKVKIHTSNPARTRRED-KHMFFEFPQPLPVCGDIKVEFFHKQNKMMKKDKMFHFWVNTFFIPGPEESGDKMENGAVNNADSQQGVPAQGQGQPQ-----SAECRDSCRESGRESDRDRDYLILTLTKNDLDKANKDKANRYFSPNFKVKLYF 366
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. TrEMBL
Match: A0A3Q3K1X2 (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Monopterus albus OX=43700 PE=3 SV=1) HSP 1 Score: 275.789 bits (704), Expect = 7.943e-82 Identity = 161/380 (42.37%), Postives = 219/380 (57.63%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++YY+ + L+ +L+Y+ L + +V + +P+ SG QFV+Y QLKV HTS R++ L + V D+K +F K +K KK+ + H W+NTFFI P + D +++ + +N + G GP +S E + QSD D L L K+++DKA KD N+ F F + F
Sbjct: 1 MAAIIKEMVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDAAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDKWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRRKFHEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNQLEYKPVALLFHKMVFETLPMFSGGTCNPQFVVY-------QLKVKIHTSNPTHTRREDKHMLFEFP-QPLPVCGDIKVEFFHKQNKMMKKDKMFHFWVNTFFI---PGPEESGDKMENGAVNNAESQQGG-PGPDQGQPHSAEVR------QSDRD----YLILTLTKNDLDKANKDKANRYFSPNFKVKLYF 356
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. TrEMBL
Match: A0A2I4AQK2 (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Austrofundulus limnaeus OX=52670 GN=LOC106513467 PE=3 SV=1) HSP 1 Score: 275.404 bits (703), Expect = 1.685e-81 Identity = 158/381 (41.47%), Postives = 225/381 (59.06%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQI-QSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M K+KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R+++Y+ + L+K L Y+ L + +V + +P+ SG QFV+Y QLKV HTS R++ + + + V D+K +F K +K KK+ + H W+NTFFI + + ++G +N S + G G +G + ++++ D + + D D + + L L K+++DKA KD N+ F F + F
Sbjct: 4 MTAKIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDAAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRKKFPEAQEALDFYGEVRTRDKKGVTIPSQRRYVHYYNYLLKKGLDYKPVALLFHKMVFETLPMFSGGTCNPQFVVY-------QLKVKIHTSNPAHTRRED-KHMIFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPDESGEKMENGAVNNVESQQGGAVPG-QGQQQSAESKDGCR------EGDRDKEYLI--LTLTKNDLDKANKDKANRYFSPNFKVKLYF 365
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. TrEMBL
Match: A0A1B6IPR6 (Uncharacterized protein OS=Homalodisca liturata OX=320908 GN=g.22824 PE=4 SV=1) HSP 1 Score: 275.404 bits (703), Expect = 2.157e-81 Identity = 152/383 (39.69%), Postives = 219/383 (57.18%), Query Frame = 3
Query: 99 NIIMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPI-ISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFE 1244
N+ M N LK LVSK++ RY QDGF+LDLSYI +IAMGFPA+ EG+YRNHIDDVV F KH +HY+IYNLC+ER D KF+ N YPF+DHNPP + C ++ +L D N+ A+ CKAGKGRTGV+VC +L +SA + L FYG++RTT+ KGVTIPSQ R++ Y+ +++ L Y + V+ + V L+ +P SG IQ VIY E KV + + K G +++ + IV D+K +F K K +KE + H W NTFF+ + + + + ++ +S + S ++ S + +DS+P + LR+ K ++D A KD NK + S F ++ V E
Sbjct: 7 NMKMTNPLKGLVSKRRKRYTQDGFNLDLSYIQENLIAMGFPAEKLEGVYRNHIDDVVKFLESKHKDHYKIYNLCSERSYDVNKFQQRVAN--YPFDDHNPPRIEVIRPFCDDVHKWLTKDKRNVAAVHCKAGKGRTGVMVCCYMLHSRQFQSANEALSFYGQKRTTDRKGVTIPSQRRYVDYYATLVQENLDYHQVVVSIRDVFLEPVPSQFSGGQGNIQLVIYNKVEEGTN-KVFSSPP--QEVKRGETRISIHLGDNVIVQGDVKLEFFSKPKMMRKEKMFHFWFNTFFVRDQAPVPEPTENGNSDLIPDRSSRSLSYEEQSHHSTFNETKPRGGSLSLDSADSRPLI--LRIGKWDLDDAHKDKTNKLYSSDFKVSLVLE 382
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Cavefish
Match: ENSAMXT00000007968.2 (phosphatase and tensin homolog [Source:NCBI gene;Acc:103025186]) HSP 1 Score: 262.692 bits (670), Expect = 2.402e-80 Identity = 153/398 (38.44%), Postives = 219/398 (55.03%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFI-LKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENY---HFNNQKSPSKMI 1286
M ++++VS+ K RY +DGFDLDL+YI +IAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L N++ AI CKAGKGRTGV++CA LL Q K A + L FYGE RT + KGVTIPSQ R++YY+ + L+ +L Y+ L + ++ + +P+ SG FV+Y QLKV HTS R++ + ++ + V D+K +F ++K KK+ + H W+NTFFI +++ ++G D E S + ++D + L L KH++DKA KD N+ F F + F N++ SPS +
Sbjct: 1 MATIIQKMVSRNKRRYQEDGFDLDLTYIYPNLIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKF--NCRVAQYPFEDHNPPQLELIRPFCEDLDKWLGEHDNHVAAIHCKAGKGRTGVMICAYLLHQGKFKKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNKLDYKPVALLFHKMMFETVPMFSGGNCNPHFVVY-------QLKVKIHTSNPGNTRREDNKCMHFEFPQPLPVCGDIKVEFFNRQNKMLKKDKMFHFWVNTFFIPGPEKLEKVENG-----------------------DLPKELDEIQSLEKGENDKDYLI--LTLTKHDLDKANKDKANRLFSPNFKVKLYFTKTLEETSNSEASPSTSV 364
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Cavefish
Match: ENSAMXT00000043891.1 (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [Source:NCBI gene;Acc:103046962]) HSP 1 Score: 262.307 bits (669), Expect = 1.382e-79 Identity = 137/290 (47.24%), Postives = 183/290 (63.10%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFI 971
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R++YY+ H L+ +L+Y+ L + +V + +P+ SG QFV+Y QLKV HTS R++ + + + V D+K +F K +K KK+ + H W+NTFFI
Sbjct: 1 MAAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHRNHYKIYNLCAERHYDAAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRQKFMEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSHLLKNQLEYKPVALLFHKMVFETLPMFSGGTCNPQFVVY-------QLKVKIHTSNPSHTRRED-KHMFFEFPQPLPVCGDIKVEFFHKQNKMMKKDKMFHFWVNTFFI 280
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Cavefish
Match: ENSAMXT00000055423.1 (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [Source:NCBI gene;Acc:103046962]) HSP 1 Score: 252.292 bits (643), Expect = 1.404e-75 Identity = 137/313 (43.77%), Postives = 185/313 (59.11%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNG-----------------------YEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFI 971
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R++YY+ H L+ +L+Y+ L + +V + +P+ SG ++ QFV+Y QLKV HTS R++ + + + V D+K +F K +K KK+ + H W+NTFFI
Sbjct: 1 MAAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHRNHYKIYNLCAERHYDAAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRQKFMEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSHLLKNQLEYKPVALLFHKMVFETLPMFSGGTCRDSTVKNRSEANPQGFKKGNWHWDPQFVVY-------QLKVKIHTSNPSHTRRED-KHMFFEFPQPLPVCGDIKVEFFHKQNKMMKKDKMFHFWVNTFFI 303
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Cavefish
Match: ENSAMXT00000038725.1 (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [Source:NCBI gene;Acc:103046962]) HSP 1 Score: 189.889 bits (481), Expect = 1.561e-53 Identity = 125/380 (32.89%), Postives = 189/380 (49.74%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE+VS+ K RY +DGFDLDL+YI IIAM ++ H+ A + ++Y +YPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL ++ A + L FYGE RT + KGVTIPSQ R++YY+ H L+ +L+Y+ L + +V + +P+ SG QFV+Y QLKV HTS R++ + + + V D+K +F K +K KK+ + H W+NTFFI P + + ++ S N + ++ + G D+D + L L K+++DKA KD N+ F F + F
Sbjct: 1 MAAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAM---------VHLQHV--------HTPAQNTRVY------------------QEEYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVAAIHCKAGKGRTGVMICAYLLHRQKFMEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSHLLKNQLEYKPVALLFHKMVFETLPMFSGGTCNPQFVVY-------QLKVKIHTSNPSHTRRED-KHMFFEFPQPLPVCGDIKVEFFHKQNKMMKKDKMFHFWVNTFFI---PGPEESPEKWENGSVVNDIDSNSSQTG------------------APDADRDYLI--LTLTKNDLDKANKDKANRYFSPNFKVKLYF 314
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Cavefish
Match: ENSAMXT00000047718.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02001063.1:308295:333196:1 gene:ENSAMXG00000032162.1 transcript:ENSAMXT00000047718.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 118.242 bits (295), Expect = 1.228e-28 Identity = 67/234 (28.63%), Postives = 122/234 (52.14%), Query Frame = 3
Query: 156 VQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGK--GVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFV-------------IYIYDREAKQLKVHHTS 812
+++G++LDL+Y+T RIIA+ FP E Y +++ DV KHA++Y + NL +RH D + +++ +P + H PP+ ++ CK ++++L++DP ++V I C+ GKGR GV++C+ + + SA L + R+ + K + PSQ R+++ L +K + L L+ ++L +P +G F+ +Y Y Q+K H S
Sbjct: 8 MEEGYELDLTYVTERIIAVSFPQSCSEETYLHNLKDVTRMLKSKHADNYLVINLSEKRH-DLTRMNPKTLDTGWP-DLHAPPL-DKICTICKAMENWLNADPLHVVVIHCRGGKGRIGVVICSFVHFTDISASADQALDRFAMRKFYDDKVSALMTPSQKRYVWILNSLLSGSMKMNASPLFLHCIILHGIPNFDNSGVCRPFIKVYQAMQAVYYSGVYKYSVIGLQVKCFHKS 238
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Sea Lamprey
Match: TNS1 (tensin 1 [Source:HGNC Symbol;Acc:HGNC:11973]) HSP 1 Score: 109.383 bits (272), Expect = 9.441e-25 Identity = 65/199 (32.66%), Postives = 105/199 (52.76%), Query Frame = 3
Query: 156 VQDGFDLDLSYITSRIIAMGFPAQSWEGI-YRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGK--GVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNG 743
++ G DL+L+YIT RII++ P + Y + DV H KHAN Y + NL RH D +KF + + +P + H PP+ + CK + +L++DP ++V I CK K RTGV+V + + SA+ L Y ++ + K ++ PSQ R++ YF L +K L L+H+V+ +P + +G
Sbjct: 7 MEGGRDLELTYITERIISLCAPTGGDSHVAYHQQMRDVARMLHSKHANGYLVINLSERRH-DIEKFNVHVRDFGWP-DLHAPPL-DVLCSICKAMDSWLNADPAHVVVIHCKGNKCRTGVVVASYMYYNGICASASQALDRYAMKKFYDDKVAKLSQPSQRRYVSYFSELLSGRVKVNNLPLFLHHIVIHGLPNLEDDG 202
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010484.1 (pep scaffold:Pmarinus_7.0:GL477590:9709:49115:-1 gene:ENSPMAG00000009496.1 transcript:ENSPMAT00000010484.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 94.3597 bits (233), Expect = 1.671e-20 Identity = 62/233 (26.61%), Postives = 105/233 (45.06%), Query Frame = 3
Query: 168 FDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERR--TTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEM---PIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEAR---KDGA 842
F+ DL+YIT RIIA P E +++ + D+ KHA+ Y I NL R+ + + N + + + P + CK I +L+S P ++ + C G GV++ A + SA L + +R +T PSQ R++YYF L +K + L+H++L P + +G + + +Y + L +++TS Y R +DGA
Sbjct: 7 FEFDLTYITERIIATTLPPGIAEHAHQSSLRDIAGMLTSKHADKYLIINLSGRRN---EMLQLNPQVLDFGWPSRHAPHLDTLCSICKAIDSWLNSHPLHVAVLHCAGNSGSAGVVIAAFMHYSAICASADQALDRFAMKRFYVEKFASLTQPSQQRYVYYFNGLLSGSIKMNSAPVYLSHILLHGAWGPPTTAFSGCGGRVFLRVY----QGLHLYYTSPVYTVRAEVRDGA 232
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010485.1 (pep scaffold:Pmarinus_7.0:GL477590:24098:49109:-1 gene:ENSPMAG00000009496.1 transcript:ENSPMAT00000010485.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 91.6633 bits (226), Expect = 3.037e-20 Identity = 61/230 (26.52%), Postives = 103/230 (44.78%), Query Frame = 3
Query: 168 FDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERR--TTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEAR---KDGA 842
F+ DL+YIT RIIA P E +++ + D+ KHA+ Y I NL R+ + + N + + + P + CK I +L+S P ++ + C G GV++ A + SA L + +R +T PSQ R++YYF L +K + L+H++L + + V ++ R + L +++TS Y R +DGA
Sbjct: 5 FEFDLTYITERIIATTLPPGIAEHAHQSSLRDIAGMLTSKHADKYLIINLSGRRN---EMLQLNPQVLDFGWPSRHAPHLDTLCSICKAIDSWLNSHPLHVAVLHCAGNSGSAGVVIAAFMHYSAICASADQALDRFAMKRFYVEKFASLTQPSQQRYVYYFNGLLSGSIKMNSAPVYLSHILLHGA-WGPPPRLDTRSVKRVFLRVYQGLHLYYTSPVYTVRAEVRDGA 230
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009584.1 (pep scaffold:Pmarinus_7.0:GL480473:6650:34123:1 gene:ENSPMAG00000008668.1 transcript:ENSPMAT00000009584.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 93.9745 bits (232), Expect = 3.954e-20 Identity = 49/144 (34.03%), Postives = 76/144 (52.78%), Query Frame = 3
Query: 171 DLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNG 602
DLD+SYIT+R+ M +PA+ E ++NHI+DV + +H +HY ++NLC +R +F HN ++ +Y F P + CK++ +L DP NI + C G+ + V VC+ L +A L Y RR G
Sbjct: 6 DLDISYITTRVAVMSYPAEGVESAFKNHIEDVRAYLDSRHPDHYAVFNLC-QRGYRPARF-HNRVS-EYAFPTRRAPNLGCLYTFCKDLLVWLKQDPKNICVVHCLDGRAVSAVAVCSFLCFCRLFSTAEAALYMYSLRRCPPG 146
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005736.1 (pep scaffold:Pmarinus_7.0:GL478791:38400:53446:1 gene:ENSPMAG00000005201.1 transcript:ENSPMAT00000005736.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 90.8929 bits (224), Expect = 5.488e-20 Identity = 61/198 (30.81%), Postives = 94/198 (47.47%), Query Frame = 3
Query: 156 VQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGK--GVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNG 743
++ G +LDL+YIT RIIA+ +P + Y I NL RH D +K + +P + H PP+ + CK + +L++DP ++V I CK KGRTGV+V + + SA L Y ++ + K V+ PSQ R++ YF L + K L L+H+V+ +P NG
Sbjct: 7 MEPGQELDLTYITERIIAVSYPPGGSQLTY--------------------ILNLSERRH-DIEKLNPQVKDFGWP-DLHAPPL-DILCSLCKAMDSWLNADPQHVVVIHCKGNKGRTGVVVASYMYYNSICASAHQALDRYAMKKFYDDKVAAVSQPSQKRYVTYFSELLSGKTKVNNMPLFLHHIVVQGLPNFEANG 181
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Yeast
Match: TEP1 (PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1 [Source:SGD;Acc:S000005072]) HSP 1 Score: 76.6406 bits (187), Expect = 3.626e-15 Identity = 61/219 (27.85%), Postives = 95/219 (43.38%), Query Frame = 3
Query: 165 GFDLDLSYITSRIIAMGFPAQSW-EGIYRNHIDDVVNFFHKKHA-NHYQIYNLCNERHIDE----------QKFE------------------------------------HNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLS--QEPDKSATDI-LQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKE 668
G LD+SYI +I +P ++ + +YRN +DD++ F H +++I+N E+ + KFE +N I + + DH PP F + E I++YL N + + C+ GKGR+G+I A L+ Q P A I +Q + TN GVTIPSQ+R++ Y E F+ E
Sbjct: 39 GLRLDISYILVNLIVCSYPVNTYPKLLYRNSLDDLILFLTVYHGKGNFRIFNFRGEKEDSDYKDNDLIGIAAKFESKDFEIQELRSTLINDGKIPISPIDLETRTLVEEETNNVICERIGWLDHFPPPFELLEEIVDGIENYLSVSKNRVAVLHCRMGKGRSGMITVAYLMKYLQCPLGEARLIFMQARFKYGMTN--GVTIPSQLRYLRYHEFFITHE 255
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Nematostella
Match: EDO32901 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STQ6]) HSP 1 Score: 235.728 bits (600), Expect = 1.931e-71 Identity = 137/374 (36.63%), Postives = 198/374 (52.94%), Query Frame = 3
Query: 120 LKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
K+LVSKKK R+ +DGFDLDL+YI I+AMGFP++ EG+YRNH+D+V F +KH + Y++YNLC+ER D +F HN + YPF+DHN P F + C ++ ++L + N+ I CKAGKGRTGV++CA LL K + +++YG RT N KGVTIPSQ R++ Y+ + LR L Y T++ L + +P + G ++I+ Y ++K+ HTS+ E+ K G S+ L + + D+K +F K FG+KE + W NTFFI G T E +SD + F + K +DKA KD K F F ++ VF
Sbjct: 4 FKQLVSKKKRRFQEDGFDLDLTYIKPNIVAMGFPSEKLEGVYRNHMDEVYRFLEQKHKDSYKVYNLCSERQYDPMRF-HNRVA-TYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGKGRTGVMICAYLLHNGHFKDTKEAMEYYGNARTRNAKGVTIPSQRRYVEYYGYLLRNCLTYVPTMVLLRGFEIITIPNMQGGNCCPFYIIWQY-----KVKI-HTSKLIESSKKGDTSIKLELSQPLPICGDIKVEFFHKDTFGRKERMFQFWFNTFFI---------------------------STGANMTDSREGEPTIHTFKESRNSDVRWFA----IPKQFVDKAHKDNKCKVFSPDFKVSNVF 338
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Nematostella
Match: EDO47071 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RN45]) HSP 1 Score: 167.548 bits (423), Expect = 5.018e-46 Identity = 80/186 (43.01%), Postives = 119/186 (63.98%), Query Frame = 3
Query: 123 KELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRT--TNGK---GVTIPSQIRFIYYFEHFLRK 665
+ ++S+ K RY QDGFDLDL+Y+T R+IAM FP+ +YRN I +V F KH++HY++YNLC+ER D F HN + + +DHN P +Q++ C ++++LD DP+N++A+ CK GKGRTG +CA L++ + A L+++G RRT + GK GV PSQ R++ Y E K
Sbjct: 29 RRMISQNKRRYQQDGFDLDLTYVTERVIAMSFPSSGKHKMYRNPISEVARFLDTKHSDHYKVYNLCSERSYDPSIF-HNQVE-RILIDDHNVPRLSQLLYFCHNVREWLDKDPSNVIAVHCKGGKGRTGTAICAWLIASGQFEQAQHSLEYFGVRRTDYSVGKTYQGVQTPSQGRYVGYLEQIFTK 212
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Nematostella
Match: EDO45782 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRM0]) HSP 1 Score: 144.436 bits (363), Expect = 2.562e-38 Identity = 82/238 (34.45%), Postives = 129/238 (54.20%), Query Frame = 3
Query: 138 KKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGK--GVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGAR 845
+ ++R+V FDLDL+YIT RIIAM FP E YRN++ DV +KH + Y ++NL +ER D K H ++ +P DH P ++ K I +L +DP ++V + CK GKGRTGV++ A + + S L ++ +R + K GVT PSQ R+++YF +L ++K + L+HV++ +P G F + +YD LK+ +TS + +D R
Sbjct: 5 RGRVRHVDHEFDLDLTYITERIIAMSFPGTGLESTYRNNLRDVAKMLQRKHQDKYMVFNL-SERRYDISKLNHQVLDFGWP--DHLAPPLERLCSIIKSIDSWLKTDPQHVVVVHCKGGKGRTGVVISAYMHFSKMCSSPEAALDWFAIKRFYDDKLGGVTQPSQRRYVHYFSDYLEGKIKLSSEPMFLHHVIVHGIPNFDSKGGCKPF-LRVYD----GLKLVYTSGVFLVTQDMER 234
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Nematostella
Match: EDO43926 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RX98]) HSP 1 Score: 103.605 bits (257), Expect = 7.932e-23 Identity = 65/191 (34.03%), Postives = 100/191 (52.36%), Query Frame = 3
Query: 171 DLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCA----CLLSQEPDKSATDILQFYGERRTTNGKGVTI-PSQIRFIYYFEHFL-RKELKYEKTVLKLNHVVLDEMP 725
DLDLSYITSRII M FPA+ E Y+N+IDDV F KH Y + N+ + R+ K ++ +P N PP+ +I C++I +L D + ++ I C G+ +GV+V A C L + P+ +A + RR G+ V + PSQ R++ Y + +K +K L + V L+ +P
Sbjct: 404 DLDLSYITSRIIVMSFPAEGIESTYKNNIDDVREFLEAKHYEQYFVVNV-SPRNYRADKLSTRVLHQCWPVN-RLPPL-ESIISLCRKIFVWLKKDSSRVIVIHCMDGRVASGVLVSAFFVFCKLFKNPNGAA----DMFSIRRCGIGQKVALTPSQERYLLYIAELINNPSMKPQKNSLYIKSVTLNPVP 587
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Nematostella
Match: EDO29614 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T353]) HSP 1 Score: 48.9062 bits (115), Expect = 1.161e-7 Identity = 24/60 (40.00%), Postives = 35/60 (58.33%), Query Frame = 3
Query: 318 CNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGK 497
C+ER D +F HN + YPF+DHN P F + C ++ ++L + N+ I CKAGK
Sbjct: 12 CSERQYDPMRF-HNRVA-TYPFDDHNAPPFELIKPFCDDVDEWLKASNLNVAIIHCKAGK 69
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Medaka
Match: ENSORLT00000040384.1 (phosphatase and tensin homolog [Source:NCBI gene;Acc:101171856]) HSP 1 Score: 266.159 bits (679), Expect = 1.521e-81 Identity = 151/379 (39.84%), Postives = 217/379 (57.26%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++ Y+ + L+ +L+Y+ L + +V + +P+ SG QFV+Y ++K+H ++ + R+D + + + V D+K +F K +K KK+ + H W+NTFFI P + D +++ S ++ + + GP + E + D D L L K+++DKA KD N+ F F + F
Sbjct: 1 MAAIIKEMVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDAAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLEAQEALDFYGEVRTRDKKGVTIPSQRRYVCYYSYLLKNQLEYKPVALLFHKMVFETLPMFSGGTCNPQFVVY-----QLKVKIHTSNPLHTRRED--KHMYFEFPQPLPVCGDIKVEFFHKQNKMMKKDKMFHFWVNTFFI---PGPEESGDRMENGSVNDAESQPS---GPGQGQPQNAECRDGCREGDRDRD----YLILTLNKNDLDKANKDKANRYFSPNFKVKLYF 360
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Medaka
Match: PTEN (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Source:NCBI gene;Acc:101173689]) HSP 1 Score: 257.299 bits (656), Expect = 3.291e-78 Identity = 159/392 (40.56%), Postives = 221/392 (56.38%), Query Frame = 3
Query: 105 IMPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPII-------SGNGYEI----QFVIYIYDREAKQLKVH-HTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
+ N +KE+VS+ K R+ +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L + +++ AI CKAGKGRTGV++CA LL + + A + L FYGE RT + KGVTIPSQ R++ Y+ + L+ L+Y+ L + ++ + +P+ SG+G + QFV+Y QLKV HTS R++ + L + V D+K +F K +K KKE + H W+NTFFI P+ S++ G P NSD S + + D++ + FL L L K+E+DKA KD NK F F + F
Sbjct: 1 MAANLIKEIVSRNKRRFQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTTKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSENEHHVAAIHCKAGKGRTGVMICAYLLHRGKFREAQEALDFYGEVRTRDKKGVTIPSQRRYVVYYNYLLKNRLQYKPVALLFHKMMFETVPMFTVGTCSESGSGPPLHAHPQFVVY-------QLKVKIHTSNPAHTRRED-KLLLFEFPQPLPVCGDIKVEFFHKQNKVMKKEKMFHFWINTFFIP-GPEEASYK-------------LENGSAAP-----NSDVSDRTYQNP-GDANDKDFLV-LTLTKNELDKANKDKANKNFSPNFKVRLFF 361
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Medaka
Match: ENSORLT00000007833.2 (phosphatase and tensin homolog [Source:NCBI gene;Acc:101171856]) HSP 1 Score: 256.529 bits (654), Expect = 1.328e-77 Identity = 151/400 (37.75%), Postives = 219/400 (54.75%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNG---------------------YEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
M +KE+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDVV F KH NHY+IYNLC ERH D KF N QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++ Y+ + L+ +L+Y+ L + +V + +P+ SG ++ QFV+Y ++K+H ++ + R+D + + + V D+K +F K +K KK+ + H W+NTFFI P + D +++ S ++ + + GP + E + D D L L K+++DKA KD N+ F F + F
Sbjct: 1 MAAIIKEMVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDAAKF--NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLEAQEALDFYGEVRTRDKKGVTIPSQRRYVCYYSYLLKNQLEYKPVALLFHKMVFETLPMFSGGTCRDVKNRSEPTPQGFKKGNWHWDPQFVVY-----QLKVKIHTSNPLHTRRED--KHMYFEFPQPLPVCGDIKVEFFHKQNKMMKKDKMFHFWVNTFFI---PGPEESGDRMENGSVNDAESQPS---GPGQGQPQNAECRDGCREGDRDRD----YLILTLNKNDLDKANKDKANRYFSPNFKVKLYF 381
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Medaka
Match: ENSORLT00000007829.2 (phosphatase and tensin homolog [Source:NCBI gene;Acc:101171856]) HSP 1 Score: 206.838 bits (525), Expect = 4.587e-59 Identity = 133/397 (33.50%), Postives = 204/397 (51.39%), Query Frame = 3
Query: 129 LVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVV----NFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNG---------------------YEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILK-SKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVF 1241
+VS+ K RY +DGFDLDL+YI IIAMGFPA+ EG+YRN+IDDV+ + Y Y + + H S+ QYPF DHNPP + C+++ +L D N++ AI CKAGKGRTGV++CA LL + A + L FYGE RT + KGVTIPSQ R++ Y+ + L+ +L+Y+ L + +V + +P+ SG ++ QFV+Y ++K+H ++ + R+D + + + V D+K +F K +K KK+ + H W+NTFFI P + D +++ S ++ + + GP + E + D D L L K+++DKA KD N+ F F + F
Sbjct: 1 MVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVLFKSLMITPLLFVSTYYYYYFISFTTLRGLACRHASVA-QYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLEAQEALDFYGEVRTRDKKGVTIPSQRRYVCYYSYLLKNQLEYKPVALLFHKMVFETLPMFSGGTCRDVKNRSEPTPQGFKKGNWHWDPQFVVY-----QLKVKIHTSNPLHTRRED--KHMYFEFPQPLPVCGDIKVEFFHKQNKMMKKDKMFHFWVNTFFI---PGPEESGDRMENGSVNDAESQPS---GPGQGQPQNAECRDGCREGDRDRD----YLILTLNKNDLDKANKDKANRYFSPNFKVKLYF 379
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Medaka
Match: tpte (phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 [Source:NCBI gene;Acc:101172265]) HSP 1 Score: 166.007 bits (419), Expect = 5.196e-44 Identity = 75/181 (41.44%), Postives = 115/181 (63.54%), Query Frame = 3
Query: 123 KELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGK-----GVTIPSQIRFIYYFE 650
+ ++S+ K RY +DGFDLDL+Y+T R+IAM FP+ + YRN I +V F KH HY+++NLC+E+ D Q F H + + +DHN P M++ +++++ +DP N++AI CK GKGRTG +VC L+ + +SA D L+++GERRT + GV PSQ R++ Y+E
Sbjct: 143 RRMISENKRRYQKDGFDLDLTYVTDRVIAMSFPSSGKQAFYRNPIKEVARFLDTKHEGHYKVFNLCSEKGYDPQHF-HYRVERVF-IDDHNVPALEDMLKFTASVREWMSADPQNVIAIHCKGGKGRTGTMVCTWLIDSDQFESAQDSLEYFGERRTDKTRSSKFQGVETPSQSRYVGYYE 321
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Planmine SMEST
Match: SMESG000043909.1 (SMESG000043909.1) HSP 1 Score: 927.932 bits (2397), Expect = 0.000e+0 Identity = 442/442 (100.00%), Postives = 442/442 (100.00%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENYHFNNQKSPSKMIRMMKPVGSGELTRVNTESGKHNAAKQNLSSDARLGDDGQTGRAHYSPCY 1433
MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENYHFNNQKSPSKMIRMMKPVGSGELTRVNTESGKHNAAKQNLSSDARLGDDGQTGRAHYSPCY
Sbjct: 1 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENYHFNNQKSPSKMIRMMKPVGSGELTRVNTESGKHNAAKQNLSSDARLGDDGQTGRAHYSPCY 442
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Planmine SMEST
Match: SMESG000072902.1 (SMESG000072902.1) HSP 1 Score: 327.405 bits (838), Expect = 4.106e-105 Identity = 175/395 (44.30%), Postives = 245/395 (62.03%), Query Frame = 3
Query: 108 MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRKELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYDREAKQLKVHHTSQFYEARKDGARSLNLLSDECFIVSDDLKFQFILKSKFGKKENLCHCWLNTFFIVHKPQIQSFQDGIKHNSNSNKVGKSAGRKGPRFTSDNSDESKTDFSHAQSDSDSQPFLYKLRLQKHEIDKACKDLNNKTFPSTFAITFVFENYHFNNQKSPSKMIRM 1292
M + ++ +VSKKK RY + GF+LDLSY+TSRIIAMGFPA+ +E +YRN IDDV FF H Y+IYNLC ER+ + KF ++PF+DHN P+FT ++ C +I +LDS P+N+VAI CKAGKGRTGVIVC L+ E +K AT LQ YG+ RT NGKGVTIPSQIR+I+Y++HF++ +LKY L L + + +P I GN E+++ IY R Q K++ + + ++D R + + + + DDLKFQF K+ G + LC CWLNTFFIV++P IQ D + SNS V K P SDE+K + + ++ +Y +RL K EID+A KD + FP F+ITF+F + N + + +I +
Sbjct: 1 MNSTIRTIVSKKKRRYKKQGFNLDLSYVTSRIIAMGFPAEKFEALYRNDIDDVSKFFEVNHCGKYKIYNLCRERNFNASKFSGEI--ARFPFDDHNAPIFTDLVACVNDIAQFLDSCPDNVVAINCKAGKGRTGVIVCCTLIHCENNKDATTALQDYGKSRTLNGKGVTIPSQIRYIFYYDHFVKNKLKYASIPLWLRKINFEMVPNI-GNA-EVEYAIY---RVNSQNKIYSSKTYKTTKQD--RQITFVESISYPLEDDLKFQFFYKTLMGGTKILCQCWLNTFFIVNQPLIQCL-DPVPRKSNSKNVFNRLPSKPP------SDEAKCPIARPEKPHEN---IYTIRLTKKEIDEANKDSTFRIFPENFSITFMFSDCPLNTDNNGNSLISI 376
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Planmine SMEST
Match: SMESG000060206.1 (SMESG000060206.1) HSP 1 Score: 149.058 bits (375), Expect = 4.589e-38 Identity = 75/181 (41.44%), Postives = 109/181 (60.22%), Query Frame = 3
Query: 123 KELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGVIVCACLLSQEPDKSATDILQFYGERRT--TNGK---GVTIPSQIRFIYYFE 650
+ + S+ K R+ G+DLDL Y+T R+IAM FP+ + +YRN I DV FF+ K+ ++Y+IYNLC ER D + F N +Y DHN P +++E K +++L NI+A+ CK GKGRTG ++C L+ +A LQ++G+RRT GK GV PSQ R++ YFE
Sbjct: 154 RHVTSENKRRFQSGGYDLDLCYVTDRVIAMSFPSSGFTALYRNSITDVAKFFNSKYGSNYKIYNLCEERAYDTKIF--NDQVERYMVKDHNVPRLEEILEFAKSSREWLTKSDQNIIAVHCKGGKGRTGTMICVHLIDSGVFDNAELCLQYFGQRRTDLLQGKKFQGVETPSQNRYVGYFE 332
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Planmine SMEST
Match: SMESG000081891.1 (SMESG000081891.1) HSP 1 Score: 81.6481 bits (200), Expect = 1.417e-15 Identity = 61/215 (28.37%), Postives = 108/215 (50.23%), Query Frame = 3
Query: 171 DLDLSYITSRIIAMGFPAQSW-EGIYRNHIDDVVNFFHKKHANHYQIYNLCNERHIDEQKFEHNSINHQYPFNDHNPPMFTQMIECCKEIQDYLDSDPNNIVAIQCKAGKGRTGV----IVCACLLSQEPDKSATDILQFYGERRTTNGKGVTIPSQIRFIYYFEHFLRK--------ELKYEKTVLKLNHVVLDEMPIISGNGYEIQFVIYIYD 776
DL+++Y+TSRII M P +S + + R+ I+DV F +H N Y IYNL + R I ++F + Q F+ P F ++ C +L +D N++ IQC G+ +G+ ++C C L + +A +I++F RR G SQ+R+I Y + E+ + K ++KL + L+ +PI + ++ + I++
Sbjct: 459 DLNITYVTSRIIMMPTPGESGIDALTRDKIEDVQTFLDFRHPNQYYIYNL-SLRSIKTERFNDRVM--QLGFDSMKPMSFNNLVSVCIHQLSWLLADAKNVIVIQCTDGRIGSGLNVAALLCFCRLV-DTSSAAVNIVKF---RR---GDCQFTSSQLRYIDYICRLMHNISNQSIGPEIPH-KFIVKLTGIELEPVPIFNRAKTGVRPYVEIFN 662 The following BLAST results are available for this feature:
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 3
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029410 ID=SMED30029410|Name=Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN|organism=Schmidtea mediterranea sexual|type=transcript|length=2173bpback to top protein sequence of SMED30029410-orf-1 >SMED30029410-orf-1 ID=SMED30029410-orf-1|Name=SMED30029410-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=468bp MPNKLKELVSKKKIRYVQDGFDLDLSYITSRIIAMGFPAQSWEGIYRNHIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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