cdc45-like protein

Overview


Name	cdc45-like protein (ACT98266.1)
Smed ID	SMED30029329
Length (bp)	721

Neoblast Clusters

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Embryonic Expression

Davies et. al., 2017

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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30029329

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Published Transcript	Transcriptome	Publication
neuron	SMED30029329	Contig40435	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
neuron	SMED30029329	Contig40435	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016
lateral branch	SMED30029329	Contig40435	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
lateral branch	SMED30029329	Contig40435	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016

Note: Hover over icons to view figure legend

Homology

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BLAST of cdc45-like protein vs. Ensembl Human
Match: CDC45 (cell division cycle 45 [Source:HGNC Symbol;Acc:HGNC:1739])

HSP 1 Score: 124.405 bits (311), Expect = 3.933e-32
Identity = 83/246 (33.74%), Postives = 144/246 (58.54%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPA-KRTKFDKKYLENKIRQR---EWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D+++     ED   + ++ D+ RP+NV N YN TQ+K+L  Q+    VP +E+IF D +E E+   ND D   P+ KRT+ +++ +E  +R+R   EW   R +I+  YE++ +HGTS+++V++ L  ++ +   ++LW AIVG T Q++ + IT+  Y     +L  ++++    +N+ E N  +     I    +L L LY+HWS  +++  +  T   F+L+ +    RL+EFL 
Sbjct:   74 LINCGANVDLLDILQPDED--TIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEARRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRH-NHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLA 316

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BLAST of cdc45-like protein vs. Ensembl Human
Match: CDC45 (cell division cycle 45 [Source:HGNC Symbol;Acc:HGNC:1739])

HSP 1 Score: 110.923 bits (276), Expect = 2.943e-27
Identity = 84/278 (30.22%), Postives = 145/278 (52.16%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPA-KRTKFDKKYLENKIRQR---EW--------------------------------RKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D+++     ED   + ++ D+ RP+NV N YN TQ+K+L  Q+    VP +E+IF D +E E+   ND D   P+ KRT+ +++ +E  +R+R   EW                                R  R +I+  YE++ +HGTS+++V++ L  ++ +   ++LW AIVG T Q++ + IT+  Y     +L  ++++    +N+ E N  +     I    +L L LY+HWS  +++  +  T   F+L+ +    RL+EFL 
Sbjct:   74 LINCGANVDLLDILQPDED--TIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEARSGSGSEPVAAALEKSSRLFAGPMSDRTAPRSPRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRH-NHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLA 348

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BLAST of cdc45-like protein vs. Ensembl Human
Match: CDC45 (cell division cycle 45 [Source:HGNC Symbol;Acc:HGNC:1739])

HSP 1 Score: 88.5817 bits (218), Expect = 8.182e-20
Identity = 65/204 (31.86%), Postives = 117/204 (57.35%), Query Frame = 1

Query:  127 QVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPA-KRTKFDKKYLENKIRQR---EWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            Q+K+L  Q+    VP +E+IF D +E E+   ND D   P+ KRT+ +++ +E  +R+R   EW   R +I+  YE++ +HGTS+++V++ L  ++ +   ++LW AIVG T Q++ + IT+  Y     +L  ++++    +N+ E N  +     I    +L L LY+HWS  +++  +  T   F+L+ +    RL+EFL 
Sbjct:   68 QIKLLIKQDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEARRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRH-NHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLA 270

[Close]

BLAST of cdc45-like protein vs. Ensembl Human
Match: CDC45 (cell division cycle 45 [Source:HGNC Symbol;Acc:HGNC:1739])

HSP 1 Score: 87.4261 bits (215), Expect = 3.434e-19
Identity = 65/204 (31.86%), Postives = 117/204 (57.35%), Query Frame = 1

Query:  127 QVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPA-KRTKFDKKYLENKIRQR---EWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            Q+K+L  Q+    VP +E+IF D +E E+   ND D   P+ KRT+ +++ +E  +R+R   EW   R +I+  YE++ +HGTS+++V++ L  ++ +   ++LW AIVG T Q++ + IT+  Y     +L  ++++    +N+ E N  +     I    +L L LY+HWS  +++  +  T   F+L+ +    RL+EFL 
Sbjct:   68 QIKLLIKQDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEARRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRH-NHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLA 270

[Close]

BLAST of cdc45-like protein vs. Ensembl Human
Match: CDC45 (cell division cycle 45 [Source:HGNC Symbol;Acc:HGNC:1739])

HSP 1 Score: 71.2478 bits (173), Expect = 9.141e-14
Identity = 44/145 (30.34%), Postives = 83/145 (57.24%), Query Frame = 1

Query:  292 RQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            ++REW   R +I+  YE++ +HGTS+++V++ L  ++ +   ++LW AIVG T Q++ + IT+  Y     +L  ++++    +N+ E N  +     I    +L L LY+HWS  +++  +  T   F+L+ +    RL+EFL 
Sbjct:    5 QRREWEARRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRH-NHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLA 148

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BLAST of cdc45-like protein vs. Ensembl Celegans
Match: evl-18 (pep chromosome:WBcel235:III:3729493:3735039:-1 gene:WBGene00009372.1 transcript:F34D10.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:evl-18)

HSP 1 Score: 48.521 bits (114), Expect = 2.076e-6
Identity = 50/225 (22.22%), Postives = 99/225 (44.00%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFD--YVPVFEEIFXXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQRE----WRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNF-ADLLHYYLTQLVAEKNDFERNRFAG-INIKSTDELTLWLYRHWSHKEAVYCS 651
            LINCGA+  +     +      + +++DS RP ++ N Y   Q+ +L    +     +P  E +  +  + E+    D+D  + +   + +K  +  K  +RE    W + R  I+  Y   ++  + + + +  + A +++ + E +W   VG  S     LI+ E Y     D +  ++ + +  KN   + +    ++I    EL L LY HW    A+  S
Sbjct:   77 LINCGATRSLTR---LQIPPASIAFVIDSHRPFHIENVYENGQIHLLANPSEMSELQIPDLESVIREDSDDEEDSDEDEDQEYISYEQRMEK--IRRKAIKREEMQIWERQRRTILWRYYESTWFSSPSCVTLLEMAAEMNRVSAETMWFTAVGLNSAMADKLISIEMYTQICVDRMRPFVHRFMP-KNIVNQGKVDDLLHITFGRELPLALYSHWDLFSAMMVS 295

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BLAST of cdc45-like protein vs. Ensembl Fly
Match: CDC45L (gene:FBgn0026143 transcript:FBtr0070182)

HSP 1 Score: 99.7525 bits (247), Expect = 1.134e-23
Identity = 76/261 (29.12%), Postives = 126/261 (48.28%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIF---------------------XXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFAGINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            L+NCG   D++E    S+D     +I DS RP++V N Y+  QV IL      + +P FE IF                     D G    D +     SR  ++  + +++ L+ + R R+W   R+ IM  Y +FS++G S +L+V+ L   + +   +LLW AIVG T Q +L  I    Y    + +  ++++L  + ND  +N  +   I   ++L L LYRHW   E++  S  +    +L+ +  + RL E L+
Sbjct:   74 LVNCGGCVDIVELLQPSDD--VTFFICDSHRPLDVCNIYSDRQVCILGDASLEENIPAFETIFYDSEGEDEDEDESSDTEQQHDDSGAGESDQEDQAPRSRKLSRLERHEQRILKQRAR-RQWESERDRIMFEYTQFSYYGRSAALMVFELAWKLSKDNMDLLWWAIVGITEQLLLGKIESGAYTLELEQIQSHVSRLTNKTND--QNTMSASKITFENDLHLVLYRHWPVTESMRYSRYSSCQLKLWTLRGEKRLHELLL 329

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BLAST of cdc45-like protein vs. Ensembl Zebrafish
Match: cdc45 (CDC45 cell division cycle 45 homolog (S. cerevisiae) [Source:ZFIN;Acc:ZDB-GENE-040426-2710])

HSP 1 Score: 89.7373 bits (221), Expect = 3.406e-20
Identity = 83/252 (32.94%), Postives = 138/252 (54.76%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXX------XXXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREE----IMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D++E     ED   V +I D+ RP++V N YN +Q+K+L  Q+    VP +++IF D +E E        + +D  +    KR +FD+  LE +I ++  R+  E     I+  YE++ FHGTS +LV++ L  ++ + T ++LW +I+G T Q++ + I    Y      L  ++++    KN+ E N  +   + I    +L L LY+HWS  E++  S  T   F+L+ I    +L+EFL 
Sbjct:   74 LINCGANVDLLETLQPEED--SVFFICDTHRPVDVVNVYNDSQIKLLIKQDDDLGVPSYDDIFRDDEEDEEADGDDSGNESDGSAEPSGKRRRFDEDALERRIERQRARREWEARRREILFDYEQYEFHGTSAALVMFELAWVMSKDTKDMLWWSIIGLTDQWVHDKIPHMKYVTDIATLQRHVSRH-NHKNEDEENSLSIDCMRINFEYDLRLVLYQHWSLYESICNSCYTSCSFKLWSINGQKKLQEFLA 322

[Close]

BLAST of cdc45-like protein vs. Ensembl Xenopus
Match: CDC45 (cell division cycle 45 [Source:NCBI gene;Acc:779545])

HSP 1 Score: 95.9005 bits (237), Expect = 4.206e-22
Identity = 78/245 (31.84%), Postives = 138/245 (56.33%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXX---XXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D++E     E+   + YI D+ RPI+V N YN +Q+K+L  Q+    +P +++IF+D ++ ED   S +  D +    KR +FD+ Y+ N          R EI+  YE++ +HGTS++++++ L  ++ + + ++LW AIVG T Q++ + IT+  Y      L  ++++    +N+ E N  +   + I    +L L LY+HWS  E++  S  T    +L+ +    +L+EFL 
Sbjct:   74 LINCGANIDLLETLQPQEE--AIFYICDTHRPIDVVNIYNDSQIKLLIRQDDDLEIPAYDDIFNDDEDEEDGDDSGNESDGAEPSGKRRRFDEVYVCNVCL---LFLCRREILFDYEQYEYHGTSSAMMMFELAWIMSKDSNDMLWWAIVGLTDQWVQDRITQMKYVTDVGTLQRHVSRH-NHRNEDEENSLSIDCMRIAFEYDLRLSLYQHWSLYESICNSCYTSASLKLWSVQGQKKLQEFLA 312

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BLAST of cdc45-like protein vs. Ensembl Xenopus
Match: CDC45 (cell division cycle 45 [Source:NCBI gene;Acc:779545])

HSP 1 Score: 93.9745 bits (232), Expect = 1.843e-21
Identity = 77/245 (31.43%), Postives = 138/245 (56.33%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXX---XXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D++E     E+   + YI D+ RPI+V N YN +Q+K+L  Q+    +P +++IF+D ++ ED   S +  D +    KR +FD+ Y  + +        R EI+  YE++ +HGTS++++++ L  ++ + + ++LW AIVG T Q++ + IT+  Y      L  ++++    +N+ E N  +   + I    +L L LY+HWS  E++  S  T    +L+ +    +L+EFL 
Sbjct:   74 LINCGANIDLLETLQPQEE--AIFYICDTHRPIDVVNIYNDSQIKLLIRQDDDLEIPAYDDIFNDDEDEEDGDDSGNESDGAEPSGKRRRFDEVYAFSCL----LFLCRREILFDYEQYEYHGTSSAMMMFELAWIMSKDSNDMLWWAIVGLTDQWVQDRITQMKYVTDVGTLQRHVSRH-NHRNEDEENSLSIDCMRIAFEYDLRLSLYQHWSLYESICNSCYTSASLKLWSVQGQKKLQEFLA 311

[Close]

BLAST of cdc45-like protein vs. Ensembl Xenopus
Match: CDC45 (cell division cycle 45 [Source:NCBI gene;Acc:779545])

HSP 1 Score: 88.9669 bits (219), Expect = 1.078e-19
Identity = 79/249 (31.73%), Postives = 142/249 (57.03%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXX---XXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREE----IMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D++E     E+   + YI D+ RPI+V N YN +Q+K+L  Q+    +P +++IF+D ++ ED   S +  D +    KR +FD+  +E +I +R  R+  E     I+  YE++ +HGTS++++++ L  ++ + + ++LW AIVG T Q++ + IT+  Y      L  ++++    +N+ E N  +   + I    +L L LY+HWS  E++  S  T    +L+ +    +L+EFL 
Sbjct:   74 LINCGANIDLLETLQPQEE--AIFYICDTHRPIDVVNIYNDSQIKLLIRQDDDLEIPAYDDIFNDDEDEEDGDDSGNESDGAEPSGKRRRFDEAAVERRIERRRQRREWEARRREILFDYEQYEYHGTSSAMMMFELAWIMSKDSNDMLWWAIVGLTDQWVQDRITQMKYVTDVGTLQRHVSRH-NHRNEDEENSLSIDCMRIAFEYDLRLSLYQHWSLYESICNSCYTSASLKLWSVQGQKKLQEFLA 319

[Close]

BLAST of cdc45-like protein vs. Ensembl Xenopus
Match: CDC45 (cell division cycle 45 [Source:NCBI gene;Acc:779545])

HSP 1 Score: 74.3294 bits (181), Expect = 1.045e-14
Identity = 68/245 (27.76%), Postives = 127/245 (51.84%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVF---EEIFXXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D++E     E+   + YI D+ RPI+V N YN +Q+K+L  Q+    +P +       +D ++ +DS +  D +    KR +FD+ Y+ N          R EI+  YE++ +HGTS++++++ L  ++ + + ++L   +    +   L ++ R  Y      L  ++++    +N+ E N  +   + I    +L L LY+HWS  E++  S  T    +L+ +    +L+EFL 
Sbjct:   74 LINCGANIDLLETLQPQEE--AIFYICDTHRPIDVVNIYNDSQIKLLIRQDDDLEIPAYDDIFNDDEDEEDGDDSGNESDGAEPSGKRRRFDEVYVCNVCL---LFLCRREILFDYEQYEYHGTSSAMMMFELAWIMSKDSNDML--CVFLYLNYITLTILPRMKYVTDVGTLQRHVSR-HNHRNEDEENSLSIDCMRIAFEYDLRLSLYQHWSLYESICNSCYTSASLKLWSVQGQKKLQEFLA 310

[Close]

BLAST of cdc45-like protein vs. Ensembl Xenopus
Match: CDC45 (cell division cycle 45 [Source:NCBI gene;Acc:779545])

HSP 1 Score: 70.4774 bits (171), Expect = 1.792e-13
Identity = 66/245 (26.94%), Postives = 125/245 (51.02%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVF---EEIFXXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D++E     E+   + YI D+ RPI+V N YN +Q+K+L  Q+    +P +       +D ++ +DS +  D +    KR +FD+ +             R EI+  YE++ +HGTS++++++ L  ++ + + ++L   +    +   L ++ R  Y      L  ++++    +N+ E N  +   + I    +L L LY+HWS  E++  S  T    +L+ +    +L+EFL 
Sbjct:   74 LINCGANIDLLETLQPQEE--AIFYICDTHRPIDVVNIYNDSQIKLLIRQDDDLEIPAYDDIFNDDEDEEDGDDSGNESDGAEPSGKRRRFDEAF------SCLLFLCRREILFDYEQYEYHGTSSAMMMFELAWIMSKDSNDML--CVFLYLNYITLTILPRMKYVTDVGTLQRHVSRH-NHRNEDEENSLSIDCMRIAFEYDLRLSLYQHWSLYESICNSCYTSASLKLWSVQGQKKLQEFLA 307

[Close]

BLAST of cdc45-like protein vs. Ensembl Mouse
Match: Cdc45 (cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073])

HSP 1 Score: 120.553 bits (301), Expect = 6.119e-31
Identity = 83/246 (33.74%), Postives = 144/246 (58.54%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPA-KRTKFDKKYLENKIRQR---EWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D+++     ED   + ++ D+ RP+NV N YN TQ+K+L  QE    VP +++IF D  E ED   +D D   P+ KRT+ +++ +E   ++R   EW   R++I+  YE++ ++GTS+++V++ L  ++ +   ++LW AIVG T Q++ + IT+  Y     +L  ++++    +N+ E N  +     I    +L L LY+HWS  E++Y +  T   F+L+ +    RL+EFL 
Sbjct:   74 LINCGANVDLLDILQPDED--SIFFVCDTHRPVNVVNVYNDTQIKLLIKQEDDLEVPAYDDIFRDEAEDEDLSDSDGDGSEPSEKRTRLEEEIVERNRKRRQRREWEARRKDILFDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLWWAIVGLTDQWVHDKITQMKYVTDVGILQRHVSRH-NHRNEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLA 316

[Close]

BLAST of cdc45-like protein vs. Ensembl Mouse
Match: Cdc45 (cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073])

HSP 1 Score: 83.5741 bits (205), Expect = 5.757e-18
Identity = 65/204 (31.86%), Postives = 117/204 (57.35%), Query Frame = 1

Query:  127 QVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPA-KRTKFDKKYLENKIRQR---EWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            Q+K+L  QE    VP +++IF D  E ED   +D D   P+ KRT+ +++ +E   ++R   EW   R++I+  YE++ ++GTS+++V++ L  ++ +   ++LW AIVG T Q++ + IT+  Y     +L  ++++    +N+ E N  +     I    +L L LY+HWS  E++Y +  T   F+L+ +    RL+EFL 
Sbjct:   68 QIKLLIKQEDDLEVPAYDDIFRDEAEDEDLSDSDGDGSEPSEKRTRLEEEIVERNRKRRQRREWEARRKDILFDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLWWAIVGLTDQWVHDKITQMKYVTDVGILQRHVSRH-NHRNEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLA 270

[Close]

BLAST of cdc45-like protein vs. Ensembl Mouse
Match: Cdc45 (cell division cycle 45 [Source:MGI Symbol;Acc:MGI:1338073])

HSP 1 Score: 56.225 bits (134), Expect = 1.082e-9
Identity = 27/63 (42.86%), Postives = 41/63 (65.08%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIF 189
            LINCGA+ D+++     ED   + ++ D+ RP+NV N YN TQ+K+L  QE    VP +++IF
Sbjct:   74 LINCGANVDLLDILQPDED--SIFFVCDTHRPVNVVNVYNDTQIKLLIKQEDDLEVPAYDDIF 134

[Close]

BLAST of cdc45-like protein vs. UniProt/SwissProt
Match: sp|O75419|CDC45_HUMAN (Cell division control protein 45 homolog OS=Homo sapiens OX=9606 GN=CDC45 PE=1 SV=1)

HSP 1 Score: 124.405 bits (311), Expect = 1.889e-31
Identity = 83/246 (33.74%), Postives = 144/246 (58.54%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPA-KRTKFDKKYLENKIRQR---EWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D+++     ED   + ++ D+ RP+NV N YN TQ+K+L  Q+    VP +E+IF D +E E+   ND D   P+ KRT+ +++ +E  +R+R   EW   R +I+  YE++ +HGTS+++V++ L  ++ +   ++LW AIVG T Q++ + IT+  Y     +L  ++++    +N+ E N  +     I    +L L LY+HWS  +++  +  T   F+L+ +    RL+EFL 
Sbjct:   74 LINCGANVDLLDILQPDED--TIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEARRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRH-NHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLA 316

[Close]

BLAST of cdc45-like protein vs. UniProt/SwissProt
Match: sp|Q9Z1X9|CDC45_MOUSE (Cell division control protein 45 homolog OS=Mus musculus OX=10090 GN=Cdc45 PE=1 SV=2)

HSP 1 Score: 120.553 bits (301), Expect = 4.280e-30
Identity = 83/246 (33.74%), Postives = 144/246 (58.54%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPA-KRTKFDKKYLENKIRQR---EWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D+++     ED   + ++ D+ RP+NV N YN TQ+K+L  QE    VP +++IF D  E ED   +D D   P+ KRT+ +++ +E   ++R   EW   R++I+  YE++ ++GTS+++V++ L  ++ +   ++LW AIVG T Q++ + IT+  Y     +L  ++++    +N+ E N  +     I    +L L LY+HWS  E++Y +  T   F+L+ +    RL+EFL 
Sbjct:   74 LINCGANVDLLDILQPDED--SIFFVCDTHRPVNVVNVYNDTQIKLLIKQEDDLEVPAYDDIFRDEAEDEDLSDSDGDGSEPSEKRTRLEEEIVERNRKRRQRREWEARRKDILFDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLWWAIVGLTDQWVHDKITQMKYVTDVGILQRHVSRH-NHRNEAEENMLSVDCTRISFEYDLCLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLA 316

[Close]

BLAST of cdc45-like protein vs. UniProt/SwissProt
Match: sp|Q9YHZ6|CDC45_XENLA (Cell division control protein 45 homolog OS=Xenopus laevis OX=8355 GN=cdc45 PE=1 SV=2)

HSP 1 Score: 98.9821 bits (245), Expect = 1.631e-22
Identity = 80/247 (32.39%), Postives = 141/247 (57.09%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHP-AKRTKFDKKYLENKIRQREWRKTREE----IMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D++E     E+   + YI D+ RPI+V N YN +QVK+L  Q+    +P +++IF+D +E  +   N+ D   P  KR +FD+  +E +I +R  R+  E     I+  YE++ +HGTS++++++ L  ++ + + ++LW AIVG T Q++ + IT+  Y      L  ++++    +N+ E N  +   + I    +L L LY+HWS  E++  S  T    +L+ +    +L+EFL 
Sbjct:   74 LINCGANIDLLETLQPQEE--AIFYICDTHRPIDVVNIYNDSQVKLLIRQDDDLEIPAYDDIFNDDEEDGEDSGNESDGAEPSGKRRRFDEAAVERRIERRRQRREWEARRREIIFDYEQYEYHGTSSAMMMFELAWIMSKDSNDMLWWAIVGLTDQWVQDRITQMKYVTDVGTLQRHVSRH-NHRNEDEENSLSIDCMRIAFEYDLRLSLYQHWSLYESICNSCYTSATLKLWSLQGQKKLQEFLA 317

[Close]

BLAST of cdc45-like protein vs. TrEMBL
Match: D2DJS9 (Cdc45-like protein (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 457.218 bits (1175), Expect = 4.272e-162
Identity = 240/240 (100.00%), Postives = 240/240 (100.00%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFAGINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKICDLRLREFLVY 720
            LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFDDGDELEDSDSNDDDSRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFAGINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKICDLRLREFLVY
Sbjct:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFDDGDELEDSDSNDDDSRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFAGINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKICDLRLREFLVY 240

[Close]

BLAST of cdc45-like protein vs. TrEMBL
Match: A0A0X3PAZ2 (Cell division control protein 45 homolog (Fragment) OS=Schistocephalus solidus OX=70667 GN=CDC45 PE=4 SV=1)

HSP 1 Score: 157.918 bits (398), Expect = 3.813e-43
Identity = 93/241 (38.59%), Postives = 142/241 (58.92%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA-GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLY-KICDLRLREFLV 717
            LINCGA+FDV+E  +  E+   + ++ DS RPINVNNFYN  QV ++T  E  D VP FE++F+D       + + +D +   + T    +  E +I +R W + R+EI+  YE FS+H T++++V++ L   + Q   +LLW AIVGQTSQ +LN I R+ Y +  D L   +++L               ++I   +ELTLWLYRHWS K+A+  + +T   F+L+ +    RL+EFL 
Sbjct:   75 LINCGANFDVVEVLEPPEN--CLFFVCDSHRPINVNNFYNQRQVHLITLNENLDDVPKFEDVFNDDLTDHSDEESGEDDQGGRQSTTV--RAAEKRINRRRWERKRQEILIEYESFSYHSTASAVVLFDLAWKLSQDNQQLLWCAIVGQTSQLMLNRINRDHYIDQIDYLQSQVSRLSHLGQALTEGLAKHAVSIDFEEELTLWLYRHWSLKDALETTMLTATRFKLFTEGGQKRLQEFLA 311

[Close]

BLAST of cdc45-like protein vs. TrEMBL
Match: A0A4S2LGK5 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_007429 PE=4 SV=1)

HSP 1 Score: 157.918 bits (398), Expect = 3.722e-41
Identity = 94/247 (38.06%), Postives = 142/247 (57.49%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKN------DFERNRFAGINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLY-KICDLRLREFLVY 720
            L+NCGA+FDV+E   +  D   + YI DS RPI++NNFYN  Q+K++   E    VP FE++F      E+S  + +      KR +   + +E +I +R+W + R++I+  YE FS+H  S+++V++ L   + Q T  LLW AIVGQTSQ + NLI RE Y +  D L  ++++L    N             A + I   DEL LWLY+HWS KE +  S VT   F+L+ +    +++EFLV+
Sbjct:   75 LLNCGANFDVLEV--LGPDTTTIFYICDSHRPIHINNFYNQRQIKLICLNEDTSDVPKFEDVFQQFSTDEESAGDSE--EEEGKRRRAGAEAIEKRIERRKWARRRQDILLDYESFSYHTVSSAVVLFDLTWRLSQETNCLLWYAIVGQTSQLLTNLINREHYVDQLDYLQSHVSRLGHAGNRANTASSVTEEGKAKVEIVLEDELALWLYKHWSLKETLETSMVTASKFKLFTEGGQKKMQEFLVH 317

[Close]

BLAST of cdc45-like protein vs. TrEMBL
Match: A0A183TCT2 (Uncharacterized protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS14280 PE=4 SV=1)

HSP 1 Score: 157.147 bits (396), Expect = 8.282e-41
Identity = 93/241 (38.59%), Postives = 142/241 (58.92%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA-GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLY-KICDLRLREFLV 717
            LINCGA+FDV+E  +  E+   + ++ DS RPINVNNFYN  QV ++T  E  D VP FE++F+D       + + +D +   + T    +  E +I +R W + R+EI+  YE FS+H T++++V++ L   + Q   +LLW AIVGQTSQ +LN I R+ Y +  D L   +++L               ++I   +ELTLWLYRHWS K+A+  + +T   F+L+ +    RL+EFL 
Sbjct:   57 LINCGANFDVVEVLEPPEN--CLFFVCDSHRPINVNNFYNQRQVHLITLNENLDDVPKFEDVFNDDLTDHSDEESGEDDQGGRQSTTV--RAAEKRINRRRWERKRQEILIEYESFSYHSTASAVVLFDLAWKLSQDNQQLLWCAIVGQTSQLMLNRINRDHYIDQIDYLQSQVSRLSHLGQALTEGLAKHAVSIDFEEELTLWLYRHWSLKDALETTMLTATRFKLFTEGGQKRLQEFLA 293

[Close]

BLAST of cdc45-like protein vs. TrEMBL
Match: A0A0X3P7H8 (Cell division control protein 45 homolog (Fragment) OS=Schistocephalus solidus OX=70667 GN=CDC45 PE=4 SV=1)

HSP 1 Score: 150.984 bits (380), Expect = 2.683e-40
Identity = 94/259 (36.29%), Postives = 138/259 (53.28%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPAKRTKFDK------------------KYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA-GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLY-KICDLRLREFLV 717
            LINCGA+FDV+E  +  E+   + ++ DS RPINVNNFYN  QV ++T  E  D VP FE++F+D        S            K D                   +  E +I +R W + R+EI+  YE FS+H T++++V++ L   + Q   +LLW AIVGQTSQ +LN I R+ Y +  D L   +++L               ++I   +ELTLWLYRHWS K+A+  + +T   F+L+ +    RL+EFL 
Sbjct:   75 LINCGANFDVVEVLEPPEN--CLFFVCDSHRPINVNNFYNQRQVHLITLNENLDDVPKFEDVFNDDLVSFLHISGSSYPSPSIISVKTDHSDEESGEDDQGGRQSTTVRAAEKRINRRRWERKRQEILIEYESFSYHSTASAVVLFDLAWKLSQDNQQLLWCAIVGQTSQLMLNRINRDHYIDQIDYLQSQVSRLSHLGQALTEGLAKHAVSIDFEEELTLWLYRHWSLKDALETTMLTATRFKLFTEGGQKRLQEFLA 331

[Close]

BLAST of cdc45-like protein vs. Ensembl Cavefish
Match: cdc45 (CDC45 cell division cycle 45 homolog (S. cerevisiae) [Source:ZFIN;Acc:ZDB-GENE-040426-2710])

HSP 1 Score: 60.8474 bits (146), Expect = 2.252e-10
Identity = 36/123 (29.27%), Postives = 68/123 (55.28%), Query Frame = 1

Query:  127 QVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHP--AKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETY 489
            Q+K+L  Q+    VP +++IF D ++ ++     D              ++ +E +  +REW   R EI+  YE++ +HGTS S+V++ L  ++ + T ++LW +I+G T Q++ + IT   Y
Sbjct:   68 QIKLLIKQDDDLGVPSYDDIFRDDEDEDEDGDGGDSGNESDGGSEPSGKRRRIERQRAKREWEARRREILFDYEQYEYHGTSASMVMFELAWVMTKDTKDMLWWSIIGLTDQWVHDKITHMKY 190

[Close]

BLAST of cdc45-like protein vs. Ensembl Nematostella
Match: EDO50060 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RF94])

HSP 1 Score: 99.7525 bits (247), Expect = 4.409e-24
Identity = 80/249 (32.13%), Postives = 130/249 (52.21%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPAKRTKFDKKYLE---NKIRQREWRKT----REEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQ--LVAEKNDFERNRFAGINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            L+NCG + +++E  +  ED     YI DS RP++++N YN  QVKIL  + +   VP F++I+   +     + +D+ S    KR K +   +     KI  +  R      R+EI+  Y  F+F+GTS S+++Y L   + +   +LLW A VG T Q+I   I  E Y + A+ LH ++ +    A++N    N    + I    EL L LYRHWS  ++++ S  T   F+++ +    +L EFL 
Sbjct:   74 LVNCGGNINLLETLEPDED--VTFYIADSHRPLDLDNIYNQDQVKILMKEGETLEVPDFDDIYAQSEVQLMGNESDEGSEPSNKRRKTEDGIIAIIGMKIMIKNNRDILSHCRQEILYRYHEFAFYGTSCSVLMYELAWKMSKDCNDLLWWAAVGLTDQYINERIDSEKYVSDAESLHEHVMRHNHGADENGVSIN---CMKITFDYELRLALYRHWSLFDSIWHSHYTACRFRVWTMKGKQKLHEFLA 317

[Close]

BLAST of cdc45-like protein vs. Ensembl Medaka
Match: cdc45 (cell division cycle 45 [Source:NCBI gene;Acc:101173790])

HSP 1 Score: 113.62 bits (283), Expect = 1.528e-28
Identity = 82/249 (32.93%), Postives = 145/249 (58.23%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIF---XXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQRE----WRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFA--GINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKI-CDLRLREFLV 717
            LINCGA+ D++E   +  DD  + +I D+ RP++V N YN TQ+K+L  Q+    VP ++EIF   D+ +E +  + +D+ S    KR +FD+  +E +I ++     W   R+EI+  YE++ +HGTS +++V+ L  ++ + T ++LW AIVG T Q++ + IT   Y      +  ++++  + +N+ E N  +   + I    +L L LY+HWS  E++  S  T  HF+L+ +    +L+E+L 
Sbjct:   74 LINCGANVDLLEM--LQPDDDSIFFICDTHRPVDVVNVYNDTQIKLLIKQDDDLAVPSYDEIFRDEDEENEDDSGNESDEGSEPSGKRRRFDEGAVERRIERQRVRREWEARRKEILFDYEQYEYHGTSAAMMVFELAWVLTKDTKDMLWWAIVGLTDQWVHDKITHMKYVTDVATMQRHVSRH-SHRNEDEENSLSIDCMRISFEYDLRLTLYQHWSLYESICNSCYTCCHFKLWTLNGQKKLQEYLA 319

[Close]

BLAST of cdc45-like protein vs. Planmine SMEST
Match: SMESG000045786.1 (SMESG000045786.1)

HSP 1 Score: 311.612 bits (797), Expect = 1.368e-103
Identity = 153/240 (63.75%), Postives = 191/240 (79.58%), Query Frame = 1

Query:    1 LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQEQFDYVPVFEEIFXXXXXXXXXXXXXXXXRHPAKRTKFDKKYLENKIRQREWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQTSQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFAGINIKSTDELTLWLYRHWSHKEAVYCSPVTLIHFQLYKICDLRLREFLVY 720
            LINCG+ FDVIE+ +I E D+RVIYILDSQRPI+VNNFYN +QVKILT QEQF YVP F ++F D  E ++S+S+DD  +  AKRTK D  YLE KIR+REW+  R EIMD YER++FHGTS+SL++Y LC LI+Q + ELLW AI+G TSQ +LN I RE+YCN  DLL  YL +LV+E+ + ++N  + IN++STDEL LWLYRHWS K+AVYC+PVTL +FQLY+I D RLREFLVY
Sbjct:   74 LINCGSQFDVIEFLNIKESDNRVIYILDSQRPIHVNNFYNASQVKILTLQEQFGYVPEFHDVFADEVESDESESDDDSYQS-AKRTKLDAAYLEEKIRRREWKSKRAEIMDIYERYAFHGTSSSLIIYSLCTLIYQESLELLWCAIIGHTSQLLLNFINRESYCNMLDLLQSYLCKLVSERKESKKNNLSEINLQSTDELALWLYRHWSLKQAVYCTPVTLTNFQLYRISDKRLREFLVY 312

The following BLAST results are available for this feature:

BLAST of cdc45-like protein vs. Ensembl Human
BLAST of cdc45-like protein vs. Ensembl Celegans
BLAST of cdc45-like protein vs. Ensembl Fly
BLAST of cdc45-like protein vs. Ensembl Zebrafish
BLAST of cdc45-like protein vs. Ensembl Xenopus
BLAST of cdc45-like protein vs. Ensembl Mouse
BLAST of cdc45-like protein vs. UniProt/SwissProt
BLAST of cdc45-like protein vs. TrEMBL
BLAST of cdc45-like protein vs. Ensembl Cavefish
BLAST of cdc45-like protein vs. Ensembl Sea Lamprey
BLAST of cdc45-like protein vs. Ensembl Yeast
BLAST of cdc45-like protein vs. Ensembl Nematostella
BLAST of cdc45-like protein vs. Ensembl Medaka
BLAST of cdc45-like protein vs. Planmine SMEST

BLAST of cdc45-like protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CDC45	3.933e-32	33.74	cell division cycle 45 [Source:HGNC Symbol;Acc:HGN...	[more]
CDC45	2.943e-27	30.22	cell division cycle 45 [Source:HGNC Symbol;Acc:HGN...	[more]
CDC45	8.182e-20	31.86	cell division cycle 45 [Source:HGNC Symbol;Acc:HGN...	[more]
CDC45	3.434e-19	31.86	cell division cycle 45 [Source:HGNC Symbol;Acc:HGN...	[more]
CDC45	9.141e-14	30.34	cell division cycle 45 [Source:HGNC Symbol;Acc:HGN...	[more]

BLAST of cdc45-like protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
evl-18	2.076e-6	22.22	pep chromosome:WBcel235:III:3729493:3735039:-1 gen...	[more]

BLAST of cdc45-like protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1


Match Name	E-value	Identity	Description
CDC45L	1.134e-23	29.12	gene:FBgn0026143 transcript:FBtr0070182	[more]

BLAST of cdc45-like protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
cdc45	3.406e-20	32.94	CDC45 cell division cycle 45 homolog (S. cerevisia...	[more]

BLAST of cdc45-like protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CDC45	4.206e-22	31.84	cell division cycle 45 [Source:NCBI gene;Acc:77954...	[more]
CDC45	1.843e-21	31.43	cell division cycle 45 [Source:NCBI gene;Acc:77954...	[more]
CDC45	1.078e-19	31.73	cell division cycle 45 [Source:NCBI gene;Acc:77954...	[more]
CDC45	1.045e-14	27.76	cell division cycle 45 [Source:NCBI gene;Acc:77954...	[more]
CDC45	1.792e-13	26.94	cell division cycle 45 [Source:NCBI gene;Acc:77954...	[more]

BLAST of cdc45-like protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Cdc45	6.119e-31	33.74	cell division cycle 45 [Source:MGI Symbol;Acc:MGI:...	[more]
Cdc45	5.757e-18	31.86	cell division cycle 45 [Source:MGI Symbol;Acc:MGI:...	[more]
Cdc45	1.082e-9	42.86	cell division cycle 45 [Source:MGI Symbol;Acc:MGI:...	[more]

BLAST of cdc45-like protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3


Match Name	E-value	Identity	Description
sp\|O75419\|CDC45_HUMAN	1.889e-31	33.74	Cell division control protein 45 homolog OS=Homo s...	[more]
sp\|Q9Z1X9\|CDC45_MOUSE	4.280e-30	33.74	Cell division control protein 45 homolog OS=Mus mu...	[more]
sp\|Q9YHZ6\|CDC45_XENLA	1.631e-22	32.39	Cell division control protein 45 homolog OS=Xenopu...	[more]

BLAST of cdc45-like protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
D2DJS9	4.272e-162	100.00	Cdc45-like protein (Fragment) OS=Schmidtea mediter...	[more]
A0A0X3PAZ2	3.813e-43	38.59	Cell division control protein 45 homolog (Fragment...	[more]
A0A4S2LGK5	3.722e-41	38.06	Uncharacterized protein OS=Opisthorchis felineus O...	[more]
A0A183TCT2	8.282e-41	38.59	Uncharacterized protein OS=Schistocephalus solidus...	[more]
A0A0X3P7H8	2.683e-40	36.29	Cell division control protein 45 homolog (Fragment...	[more]

BLAST of cdc45-like protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
cdc45	2.252e-10	29.27	CDC45 cell division cycle 45 homolog (S. cerevisia...	[more]

BLAST of cdc45-like protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of cdc45-like protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of cdc45-like protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO50060	4.409e-24	32.13	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of cdc45-like protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
cdc45	1.528e-28	32.93	cell division cycle 45 [Source:NCBI gene;Acc:10117...	[more]

BLAST of cdc45-like protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000045786.1	1.368e-103	63.75	SMESG000045786.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30029329
GenBank	ACT98266.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30029329 ID=SMED30029329|Name=cdc45-like protein|organism=Schmidtea mediterranea sexual|type=transcript|length=721bp
CTGATAAATTGTGGAGCATCATTTGACGTGATAGAATATTTTGACATCAG
TGAAGATGACCACAGGGTGATTTATATTCTCGACAGCCAAAGACCTATTA
ATGTTAATAATTTCTACAATTTCACTCAAGTAAAAATTTTGACTTTCCAA
GAACAGTTTGATTATGTTCCAGTCTTTGAAGAAATCTTTGATGATGGTGA
CGAATTAGAAGATTCAGATTCTAATGATGATGACTCCCGACATCCAGCTA
AGCGAACTAAGTTTGATAAAAAATATTTAGAAAACAAAATTCGTCAAAGA
GAATGGAGAAAAACACGTGAAGAAATAATGGATTGTTATGAAAGATTTTC
ATTTCACGGAACATCAACAAGCTTAGTCGTGTACCACTTGTGTGCTTTGA
TCCATCAAACTACCTTTGAGCTGCTTTGGAGTGCAATTGTCGGTCAAACA
AGCCAATTTATATTAAACCTTATTACTCGAGAGACTTACTGCAATTTTGC
CGATCTGCTTCATTACTACCTGACTCAGCTGGTTGCTGAAAAAAATGATT
TCGAACGAAATAGATTTGCAGGAATTAATATAAAATCCACAGACGAATTA
ACACTTTGGCTATACCGACATTGGTCTCATAAAGAAGCTGTATATTGCAG
TCCTGTAACTCTCATTCATTTCCAACTATATAAAATTTGTGACCTTAGGC
TCAGAGAGTTCCTTGTTTACA

protein sequence of SMED30029329-orf-1

>SMED30029329-orf-1 ID=SMED30029329-orf-1|Name=SMED30029329-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=240bp
LINCGASFDVIEYFDISEDDHRVIYILDSQRPINVNNFYNFTQVKILTFQ
EQFDYVPVFEEIFDDGDELEDSDSNDDDSRHPAKRTKFDKKYLENKIRQR
EWRKTREEIMDCYERFSFHGTSTSLVVYHLCALIHQTTFELLWSAIVGQT
SQFILNLITRETYCNFADLLHYYLTQLVAEKNDFERNRFAGINIKSTDEL
TLWLYRHWSHKEAVYCSPVTLIHFQLYKICDLRLREFLVY

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000461	lateral branch

Vocabulary: **INTERPRO**
Term	Definition
IPR003874	CDC45

Vocabulary: **biological process**
Term	Definition
GO:0006270	DNA replication initiation
GO:0051301	cell division

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR003874	CDC45 family	PFAM	PF02724	CDC45	coord: 70..227 e-value: 2.2E-25 score: 89.1
IPR003874	CDC45 family	PANTHER	PTHR10507	CDC45-RELATED PROTEIN	coord: 1..238
None	No IPR available	PANTHER	PTHR10507:SF0	CELL DIVISION CONTROL PROTEIN 45 HOMOLOG	coord: 1..238

Main menu

cdc45-like protein

Zeng et. al., 2018

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Owlery

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