Thyroid receptor-interacting protein 11
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029318 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 10
Homology
BLAST of Thyroid receptor-interacting protein 11 vs. TrEMBL
Match: A0A2R2MLR4 (thyroid receptor-interacting protein 11 isoform X12 OS=Lingula unguis OX=7574 GN=LOC106159831 PE=4 SV=1) HSP 1 Score: 90.8929 bits (224), Expect = 2.429e-15 Identity = 50/122 (40.98%), Postives = 78/122 (63.93%), Query Frame = 1 Query: 1087 EDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSD----QTDGSAMKC---------IESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWN 1413 EDM +E +++L+ M+R+KE EIEALK KN +L ++Q+ + Q + M + ++ E+E+LSK+LA YQ++REQ+I+AL KH+ES+ YH EIQRL A ++ E K + Sbjct: 1222 EDMTREAIQNLSHMVRNKEMEIEALKQKNETLLMVLQESSPNSPAPQKGATVMAGGGANTNSVQVGLLMQERENLSKQLAAYQQDREQIIAALTQKHQESVAYHTEIQRLTACLSTETQKMD 1343
BLAST of Thyroid receptor-interacting protein 11 vs. TrEMBL
Match: A0A2R2MLR6 (thyroid receptor-interacting protein 11 isoform X11 OS=Lingula unguis OX=7574 GN=LOC106159831 PE=4 SV=1) HSP 1 Score: 90.8929 bits (224), Expect = 2.761e-15 Identity = 50/122 (40.98%), Postives = 78/122 (63.93%), Query Frame = 1 Query: 1087 EDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSD----QTDGSAMKC---------IESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWN 1413 EDM +E +++L+ M+R+KE EIEALK KN +L ++Q+ + Q + M + ++ E+E+LSK+LA YQ++REQ+I+AL KH+ES+ YH EIQRL A ++ E K + Sbjct: 1370 EDMTREAIQNLSHMVRNKEMEIEALKQKNETLLMVLQESSPNSPAPQKGATVMAGGGANTNSVQVGLLMQERENLSKQLAAYQQDREQIIAALTQKHQESVAYHTEIQRLTACLSTETQKMD 1491
BLAST of Thyroid receptor-interacting protein 11 vs. TrEMBL
Match: A0A2R2MLQ9 (thyroid receptor-interacting protein 11 isoform X8 OS=Lingula unguis OX=7574 GN=LOC106159831 PE=4 SV=1) HSP 1 Score: 90.8929 bits (224), Expect = 2.942e-15 Identity = 50/122 (40.98%), Postives = 78/122 (63.93%), Query Frame = 1 Query: 1087 EDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSD----QTDGSAMKC---------IESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWN 1413 EDM +E +++L+ M+R+KE EIEALK KN +L ++Q+ + Q + M + ++ E+E+LSK+LA YQ++REQ+I+AL KH+ES+ YH EIQRL A ++ E K + Sbjct: 1504 EDMTREAIQNLSHMVRNKEMEIEALKQKNETLLMVLQESSPNSPAPQKGATVMAGGGANTNSVQVGLLMQERENLSKQLAAYQQDREQIIAALTQKHQESVAYHTEIQRLTACLSTETQKMD 1625
BLAST of Thyroid receptor-interacting protein 11 vs. TrEMBL
Match: A0A2R2MLR3 (thyroid receptor-interacting protein 11 isoform X7 OS=Lingula unguis OX=7574 GN=LOC106159831 PE=4 SV=1) HSP 1 Score: 90.8929 bits (224), Expect = 2.972e-15 Identity = 50/122 (40.98%), Postives = 78/122 (63.93%), Query Frame = 1 Query: 1087 EDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSD----QTDGSAMKC---------IESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWN 1413 EDM +E +++L+ M+R+KE EIEALK KN +L ++Q+ + Q + M + ++ E+E+LSK+LA YQ++REQ+I+AL KH+ES+ YH EIQRL A ++ E K + Sbjct: 1521 EDMTREAIQNLSHMVRNKEMEIEALKQKNETLLMVLQESSPNSPAPQKGATVMAGGGANTNSVQVGLLMQERENLSKQLAAYQQDREQIIAALTQKHQESVAYHTEIQRLTACLSTETQKMD 1642
BLAST of Thyroid receptor-interacting protein 11 vs. TrEMBL
Match: A0A2R2MLN5 (thyroid receptor-interacting protein 11 isoform X6 OS=Lingula unguis OX=7574 GN=LOC106159831 PE=4 SV=1) HSP 1 Score: 90.8929 bits (224), Expect = 3.161e-15 Identity = 50/122 (40.98%), Postives = 78/122 (63.93%), Query Frame = 1 Query: 1087 EDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSD----QTDGSAMKC---------IESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWN 1413 EDM +E +++L+ M+R+KE EIEALK KN +L ++Q+ + Q + M + ++ E+E+LSK+LA YQ++REQ+I+AL KH+ES+ YH EIQRL A ++ E K + Sbjct: 1523 EDMTREAIQNLSHMVRNKEMEIEALKQKNETLLMVLQESSPNSPAPQKGATVMAGGGANTNSVQVGLLMQERENLSKQLAAYQQDREQIIAALTQKHQESVAYHTEIQRLTACLSTETQKMD 1644
BLAST of Thyroid receptor-interacting protein 11 vs. Planmine SMEST
Match: SMESG000037100.1 (SMESG000037100.1) HSP 1 Score: 800.045 bits (2065), Expect = 0.000e+0 Identity = 488/511 (95.50%), Postives = 490/511 (95.89%), Query Frame = 1 Query: 22 NDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSQCQLTIANLDREKSDLLAKNTELDEQLLDFSITVARYEGLETVCDRYQRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---NLTMDSDDILEHVETFNQEKDECIQALESKIISLQNLCEEKDDDIAELTQRERDIVFEYDSLIEVLKAELESVRTALEKHGXXXXXXXXXXXXXXXXXXXKESMITCLNEELTMLSVIDSDDLHAXXXXXXXXXXXXHGSIGTDGFSQTDPVNDPSTESSIIGLERQIGCLLTEKERLEQVLEAQANSLGQYEVKVSKLQSELSRVSNQSGDQSQSSLAMAXXXXXXXXX--------MEDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSDQTDGSAMKCIESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWNXXXXXXXXXXXXXXXDAIRSVPGADQHLVTAPDQHL 1521 NDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSQCQLTIANLDREKSDLLAKNTELDEQLLDFSITVARYEGLETVCDRYQRQLAALSAVSRQQQQQQ +P+A A A NLTMDSDDILEHVETFNQEKDECIQALESKIISLQNLCEEKDDDIAELTQRERDIVFEYDSLIEVLKAELESVRTALEKHGENEQALRRQLQELQETLQQKESMITCLNEELTMLSVIDSDDLHAQQPLPQQQPQSQHGSIGTDGFSQTDPVNDPSTESSIIGLERQIGCLLTEKERLEQVLEAQANSLGQYEVKVSKLQSELSRVSNQSGDQSQSSLAMATGTGTGTGT MEDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSDQTDGSAMKCIESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWNEMDQLRQQQMQQRDEDAIRSVPGADQHLVTAPDQHL Sbjct: 603 NDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSQCQLTIANLDREKSDLLAKNTELDEQLLDFSITVARYEGLETVCDRYQRQLAALSAVSRQQQQQQQQQSPSAPAAAVIATAPAANLTMDSDDILEHVETFNQEKDECIQALESKIISLQNLCEEKDDDIAELTQRERDIVFEYDSLIEVLKAELESVRTALEKHGENEQALRRQLQELQETLQQKESMITCLNEELTMLSVIDSDDLHAQQPLPQQQPQSQHGSIGTDGFSQTDPVNDPSTESSIIGLERQIGCLLTEKERLEQVLEAQANSLGQYEVKVSKLQSELSRVSNQSGDQSQSSLAMATGTGTGTGTGTGTGTGTMEDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSDQTDGSAMKCIESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWNEMDQLRQQQMQQRDEDAIRSVPGADQHLVTAPDQHL 1113
BLAST of Thyroid receptor-interacting protein 11 vs. Planmine SMEST
Match: SMESG000037100.1 (SMESG000037100.1) HSP 1 Score: 800.045 bits (2065), Expect = 0.000e+0 Identity = 488/511 (95.50%), Postives = 490/511 (95.89%), Query Frame = 1 Query: 22 NDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSQCQLTIANLDREKSDLLAKNTELDEQLLDFSITVARYEGLETVCDRYQRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---NLTMDSDDILEHVETFNQEKDECIQALESKIISLQNLCEEKDDDIAELTQRERDIVFEYDSLIEVLKAELESVRTALEKHGXXXXXXXXXXXXXXXXXXXKESMITCLNEELTMLSVIDSDDLHAXXXXXXXXXXXXHGSIGTDGFSQTDPVNDPSTESSIIGLERQIGCLLTEKERLEQVLEAQANSLGQYEVKVSKLQSELSRVSNQSGDQSQSSLAMAXXXXXXXXX--------MEDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSDQTDGSAMKCIESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWNXXXXXXXXXXXXXXXDAIRSVPGADQHLVTAPDQHL 1521 NDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSQCQLTIANLDREKSDLLAKNTELDEQLLDFSITVARYEGLETVCDRYQRQLAALSAVSRQQQQQQ +P+A A A NLTMDSDDILEHVETFNQEKDECIQALESKIISLQNLCEEKDDDIAELTQRERDIVFEYDSLIEVLKAELESVRTALEKHGENEQALRRQLQELQETLQQKESMITCLNEELTMLSVIDSDDLHAQQPLPQQQPQSQHGSIGTDGFSQTDPVNDPSTESSIIGLERQIGCLLTEKERLEQVLEAQANSLGQYEVKVSKLQSELSRVSNQSGDQSQSSLAMATGTGTGTGT MEDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSDQTDGSAMKCIESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWNEMDQLRQQQMQQRDEDAIRSVPGADQHLVTAPDQHL Sbjct: 604 NDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSQCQLTIANLDREKSDLLAKNTELDEQLLDFSITVARYEGLETVCDRYQRQLAALSAVSRQQQQQQQQQSPSAPAAAVIATAPAANLTMDSDDILEHVETFNQEKDECIQALESKIISLQNLCEEKDDDIAELTQRERDIVFEYDSLIEVLKAELESVRTALEKHGENEQALRRQLQELQETLQQKESMITCLNEELTMLSVIDSDDLHAQQPLPQQQPQSQHGSIGTDGFSQTDPVNDPSTESSIIGLERQIGCLLTEKERLEQVLEAQANSLGQYEVKVSKLQSELSRVSNQSGDQSQSSLAMATGTGTGTGTGTGTGTGTMEDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSDQTDGSAMKCIESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWNEMDQLRQQQMQQRDEDAIRSVPGADQHLVTAPDQHL 1114
BLAST of Thyroid receptor-interacting protein 11 vs. Planmine SMEST
Match: SMESG000037100.1 (SMESG000037100.1) HSP 1 Score: 798.89 bits (2062), Expect = 0.000e+0 Identity = 488/511 (95.50%), Postives = 490/511 (95.89%), Query Frame = 1 Query: 22 NDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSQCQLTIANLDREKSDLLAKNTELDEQLLDFSITVARYEGLETVCDRYQRXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX---NLTMDSDDILEHVETFNQEKDECIQALESKIISLQNLCEEKDDDIAELTQRERDIVFEYDSLIEVLKAELESVRTALEKHGXXXXXXXXXXXXXXXXXXXKESMITCLNEELTMLSVIDSDDLHAXXXXXXXXXXXXHGSIGTDGFSQTDPVNDPSTESSIIGLERQIGCLLTEKERLEQVLEAQANSLGQYEVKVSKLQSELSRVSNQSGDQSQSSLAMAXXXXXXXXX--------MEDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSDQTDGSAMKCIESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWNXXXXXXXXXXXXXXXDAIRSVPGADQHLVTAPDQHL 1521 NDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSQCQLTIANLDREKSDLLAKNTELDEQLLDFSITVARYEGLETVCDRYQRQLAALSAVSRQQQQQQ +P+A A A NLTMDSDDILEHVETFNQEKDECIQALESKIISLQNLCEEKDDDIAELTQRERDIVFEYDSLIEVLKAELESVRTALEKHGENEQALRRQLQELQETLQQKESMITCLNEELTMLSVIDSDDLHAQQPLPQQQPQSQHGSIGTDGFSQTDPVNDPSTESSIIGLERQIGCLLTEKERLEQVLEAQANSLGQYEVKVSKLQSELSRVSNQSGDQSQSSLAMATGTGTGTGT MEDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSDQTDGSAMKCIESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWNEMDQLRQQQMQQRDEDAIRSVPGADQHLVTAPDQHL Sbjct: 609 NDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSQCQLTIANLDREKSDLLAKNTELDEQLLDFSITVARYEGLETVCDRYQRQLAALSAVSRQQQQQQQQQSPSAPAAAVIATAPAANLTMDSDDILEHVETFNQEKDECIQALESKIISLQNLCEEKDDDIAELTQRERDIVFEYDSLIEVLKAELESVRTALEKHGENEQALRRQLQELQETLQQKESMITCLNEELTMLSVIDSDDLHAQQPLPQQQPQSQHGSIGTDGFSQTDPVNDPSTESSIIGLERQIGCLLTEKERLEQVLEAQANSLGQYEVKVSKLQSELSRVSNQSGDQSQSSLAMATGTGTGTGTGTGTGTGTMEDMAKETLRHLAQMIRDKEWEIEALKSKNSSLCEIIQKFGSDQTDGSAMKCIESVLNEKESLSKELAWYQENREQLISALNLKHKESLNYHGEIQRLIAYINVEQSKWNEMDQLRQQQMQQRDEDAIRSVPGADQHLVTAPDQHL 1119 The following BLAST results are available for this feature:
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Thyroid receptor-interacting protein 11 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 3
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029318 ID=SMED30029318|Name=Thyroid receptor-interacting protein 11|organism=Schmidtea mediterranea sexual|type=transcript|length=1523bpback to top protein sequence of SMED30029318-orf-1 >SMED30029318-orf-1 ID=SMED30029318-orf-1|Name=SMED30029318-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=507bp MSASISANDRPLDTMAILATIKHSFTEMKETCSVHNYIEQENKSLQQLVSback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|