Uro-adherence factor A
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029236 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Uro-adherence factor A vs. TrEMBL
Match: A0A448WQW4 (Uncharacterized protein (Fragment) OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS11379 PE=4 SV=1) HSP 1 Score: 117.857 bits (294), Expect = 2.468e-25 Identity = 52/98 (53.06%), Postives = 70/98 (71.43%), Query Frame = 2 Query: 2165 FKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSC----QAFRNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFLKLNAR 2446 + R F+L PYDD++K+HLNP DRR+K+VAAKNGC I I GP + L QA R ++TY+C VAGP + ++KC+NYLKETFPN+FL++ R Sbjct: 197 YAYERLFQLGPYDDLVKSHLNPADRRIKAVAAKNGCYIGITGPKLIHPDLDSAGGFQASRARITYQCCVAGPTGDKVNKCLNYLKETFPNSFLRITFR 294
BLAST of Uro-adherence factor A vs. TrEMBL
Match: A0A4E0RAI5 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_005915 PE=4 SV=1) HSP 1 Score: 115.546 bits (288), Expect = 1.795e-22 Identity = 52/95 (54.74%), Postives = 68/95 (71.58%), Query Frame = 2 Query: 2165 FKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSCQAF-RNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFLKLNAR 2446 F+V R FEL+ YDD++K+HLN DRR+K+VA KNGCRI I GP D C A R K Y C +AGP+++ + KC+N+LKETFPN+FL+ N R Sbjct: 909 FEVERVFELNQYDDLVKSHLNAADRRIKAVALKNGCRIRITGPFTKPDTSLCGAANRGKTLYNCHIAGPSEDRIGKCVNFLKETFPNSFLRTNWR 1003
BLAST of Uro-adherence factor A vs. TrEMBL
Match: A0A2H1C7I4 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_09542 PE=4 SV=1) HSP 1 Score: 114.775 bits (286), Expect = 4.257e-22 Identity = 52/95 (54.74%), Postives = 68/95 (71.58%), Query Frame = 2 Query: 2165 FKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSCQAF-RNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFLKLNAR 2446 F+V R FEL+ YDD++K+HLN DRR+K+VA KNGCRI I GP D C A R K Y C +AGP+++ + KC+N+LKETFPN+FL+ N R Sbjct: 1492 FEVERVFELNQYDDLVKSHLNAADRRIKAVALKNGCRIRITGPFTKPDTSLCGAANRGKTLYNCHIAGPSEDRIGKCVNFLKETFPNSFLRTNWR 1586
BLAST of Uro-adherence factor A vs. TrEMBL
Match: A0A504Y9H7 (Uncharacterized protein OS=Fasciola gigantica OX=46835 GN=FGIG_09034 PE=4 SV=1) HSP 1 Score: 114.39 bits (285), Expect = 6.595e-22 Identity = 52/95 (54.74%), Postives = 68/95 (71.58%), Query Frame = 2 Query: 2165 FKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSCQ-AFRNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFLKLNAR 2446 F+V R FEL+ YDD++K+HLN DRR+K+VA KNGCRI I GP D C A R K Y C +AGP+++ + KC+N+LKETFPN+FL+ N R Sbjct: 1529 FEVERVFELNQYDDLVKSHLNAADRRIKAVALKNGCRIRITGPFTKPDTSLCGVANRGKTLYNCHIAGPSEDRIGKCVNFLKETFPNSFLRTNWR 1623
BLAST of Uro-adherence factor A vs. TrEMBL
Match: A0A183AF89 (Uncharacterized protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS5624 PE=4 SV=1) HSP 1 Score: 111.694 bits (278), Expect = 3.280e-21 Identity = 50/95 (52.63%), Postives = 72/95 (75.79%), Query Frame = 2 Query: 2165 FKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSCQ-AFRNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFLKLNAR 2446 F+V R FELS YDD++K++LN DRR+K+VA KNGC I I GPI DP + + R+++T+ C +AGP+++ + KC+N+LKETFPN+FL+ N R Sbjct: 1018 FEVERIFELSQYDDLVKSYLNVADRRIKAVALKNGCDIRIVGPITKPDPSAIGISGRSRITFNCHIAGPSEDRIGKCVNFLKETFPNSFLRTNWR 1112
BLAST of Uro-adherence factor A vs. Planmine SMEST
Match: SMESG000076818.1 (SMESG000076818.1) HSP 1 Score: 1399.03 bits (3620), Expect = 0.000e+0 Identity = 783/783 (100.00%), Postives = 783/783 (100.00%), Query Frame = 2 Query: 104 MIFINNNNTQSDKYFHDNKSQISNKTYFKRLTNSNQEYIGSNDPDYSNFLNQYKRDTNTDEFSNTRHVDNLEDIIAHPLASRRNLHNTDINPTESWLFKNNQRXXXXXXXXXXXXXEALENYLNDLAKNYDDIDRRIRNAEKFVNKIEESHNANFNSIDRFINSRNNFTLNDKPIEIPEKSTNYVSELRVNILDNAVNNPLSSNNDQINXXXXXXXXXXXXXXXYKKPTSSKHSIFSRKPSFSGQNNVXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLEYVNIPPPKVFSSNYFKNETLKSKTVQTVDNVAYLKMFPQQSLEDRSVQTNSPVTCLSKVTVDVCVGTESKLIKSRIKLNSSRNSIITNNLSDTGMEFSDSDRSISLIKSSKNEYSDMIAGDIEDHNSIAKTAVFRNRIKTPPNKSNLVNFKGDDPSKTLEPLIQSNIKSSKSENWNRCSSNIGKFNKNKVLKFSPNHGNSKEEKTSLPKVGWNDKINFEHDNSDNKNSTKNASLEIQRLLENLGTHLQASMSLRKTRAALIKSPISSNSSTASFWDNPLHKNDLISTKLTPGCTIGTKATNSCLKVNRANNMINSELQAICKTIEKNKKFDSRSIKVHXXXXXXXXXXXXGKNNLKTLRSESLDMRPLIKPKSSPTRNNSTVKKAASNINLSGDNKFPSNFKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSCQAFRNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFLKLNARNA 2452 MIFINNNNTQSDKYFHDNKSQISNKTYFKRLTNSNQEYIGSNDPDYSNFLNQYKRDTNTDEFSNTRHVDNLEDIIAHPLASRRNLHNTDINPTESWLFKNNQRNNSDDSINNPSDDEALENYLNDLAKNYDDIDRRIRNAEKFVNKIEESHNANFNSIDRFINSRNNFTLNDKPIEIPEKSTNYVSELRVNILDNAVNNPLSSNNDQINLSFKKSPKFSRSSLLYKKPTSSKHSIFSRKPSFSGQNNVYKCNYKNITTNNYKNLTSEFQSPKSGSSSFSNSNKSNLEYVNIPPPKVFSSNYFKNETLKSKTVQTVDNVAYLKMFPQQSLEDRSVQTNSPVTCLSKVTVDVCVGTESKLIKSRIKLNSSRNSIITNNLSDTGMEFSDSDRSISLIKSSKNEYSDMIAGDIEDHNSIAKTAVFRNRIKTPPNKSNLVNFKGDDPSKTLEPLIQSNIKSSKSENWNRCSSNIGKFNKNKVLKFSPNHGNSKEEKTSLPKVGWNDKINFEHDNSDNKNSTKNASLEIQRLLENLGTHLQASMSLRKTRAALIKSPISSNSSTASFWDNPLHKNDLISTKLTPGCTIGTKATNSCLKVNRANNMINSELQAICKTIEKNKKFDSRSIKVHESSSSDMESIISGKNNLKTLRSESLDMRPLIKPKSSPTRNNSTVKKAASNINLSGDNKFPSNFKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSCQAFRNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFLKLNARNA Sbjct: 1 MIFINNNNTQSDKYFHDNKSQISNKTYFKRLTNSNQEYIGSNDPDYSNFLNQYKRDTNTDEFSNTRHVDNLEDIIAHPLASRRNLHNTDINPTESWLFKNNQRNNSDDSINNPSDDEALENYLNDLAKNYDDIDRRIRNAEKFVNKIEESHNANFNSIDRFINSRNNFTLNDKPIEIPEKSTNYVSELRVNILDNAVNNPLSSNNDQINLSFKKSPKFSRSSLLYKKPTSSKHSIFSRKPSFSGQNNVYKCNYKNITTNNYKNLTSEFQSPKSGSSSFSNSNKSNLEYVNIPPPKVFSSNYFKNETLKSKTVQTVDNVAYLKMFPQQSLEDRSVQTNSPVTCLSKVTVDVCVGTESKLIKSRIKLNSSRNSIITNNLSDTGMEFSDSDRSISLIKSSKNEYSDMIAGDIEDHNSIAKTAVFRNRIKTPPNKSNLVNFKGDDPSKTLEPLIQSNIKSSKSENWNRCSSNIGKFNKNKVLKFSPNHGNSKEEKTSLPKVGWNDKINFEHDNSDNKNSTKNASLEIQRLLENLGTHLQASMSLRKTRAALIKSPISSNSSTASFWDNPLHKNDLISTKLTPGCTIGTKATNSCLKVNRANNMINSELQAICKTIEKNKKFDSRSIKVHESSSSDMESIISGKNNLKTLRSESLDMRPLIKPKSSPTRNNSTVKKAASNINLSGDNKFPSNFKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSCQAFRNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFLKLNARNA 783
BLAST of Uro-adherence factor A vs. Planmine SMEST
Match: SMESG000050742.1 (SMESG000050742.1) HSP 1 Score: 127.487 bits (319), Expect = 3.220e-30 Identity = 95/259 (36.68%), Postives = 136/259 (52.51%), Query Frame = 2 Query: 1679 LLENLGTHLQASMSLRKTRAALIKSPISSNSSTA--SFWDNPLHKNDLISTKLTPGCTIGTKATNSCLKVNRANNMINSELQAICKTIEKNKKFDSRSIKVHXXXXXXXXXXXXGKNNLKTL---RSESLDMRPLIKPKSSPTRNNSTVKKAASNINLSGD-NKFPSNFKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSCQAF--RNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFL 2431 +LENLG HLQ S + K I N SFWDNPL K +L+ ++ K L+ + N N L + + K+ +S + + +LK L +S S + RPL P SN N++ N P++ K +SF L+PYDD++K+HLN DRR+KSVA+KNG IAI+GP+N+Y+ + Q F ++K+ +RCT++ N ENLDKC+NYLKETFPNT+L Sbjct: 370 ILENLGIHLQNSGTPL-ANVCQKKQNIRQNKDNNFNSFWDNPLDKFELVHSE---NNETNRKGFQLKLQEHPTGN-TNGNLDEA--------HYQQKHAKIEIENSKTALTENDEEKSLKILTQTKSVSRENRPLTLP-------------LGSNFNINRKINFMPTSMKFSKSFYLNPYDDMVKSHLNSADRRIKSVASKNGSVIAIEGPLNAYENQN-QNFQTKSKMIFRCTISSSNSENLDKCVNYLKETFPNTYL 601
BLAST of Uro-adherence factor A vs. Planmine SMEST
Match: SMESG000024364.1 (SMESG000024364.1) HSP 1 Score: 81.2629 bits (199), Expect = 8.412e-16 Identity = 43/103 (41.75%), Postives = 68/103 (66.02%), Query Frame = 2 Query: 2132 NLSGDNKFPSNFKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGP--INSYDPLSCQAFRNKVTYRCTVAGPNKENLDKCMNYLKETFPNTFLK 2434 +LS D P+NF+ + F LSP+D+IIK+H P DRR+++VA K C+I I GP ++ + P S R K+ + C ++G +K NL+KC+ +K+TFP T ++ Sbjct: 324 HLSSD---PNNFQ--KVFVLSPFDEIIKSHTCPNDRRLRAVANKMRCKIDIFGPMKVSHFTP-SFYTTREKIIFHCVLSGDSKYNLEKCLKCIKDTFPTTTIR 420
BLAST of Uro-adherence factor A vs. Planmine SMEST
Match: SMESG000071919.1 (SMESG000071919.1) HSP 1 Score: 52.7582 bits (125), Expect = 4.334e-7 Identity = 31/88 (35.23%), Postives = 51/88 (57.95%), Query Frame = 2 Query: 2165 FKVFRSFELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPINSYDPLSCQAFRNKVT-YRCTVAGPNKENLDKCMNYLKETFPNT 2425 + +R FEL +D+IIK+H DRR+K+++ + C++ I GP S + S Q R V Y V NK L+K +N ++ +FP++ Sbjct: 181 WDYYRVFELKKFDEIIKSHQARSDRRLKAISNRMLCKLDIIGPYQSTN--SQQNSRTAVDWYNLIVYASNKLRLEKSINCIQLSFPSS 266
BLAST of Uro-adherence factor A vs. Planmine SMEST
Match: SMESG000012235.1 (SMESG000012235.1) HSP 1 Score: 51.6026 bits (122), Expect = 2.494e-6 Identity = 30/94 (31.91%), Postives = 51/94 (54.26%), Query Frame = 2 Query: 2165 FKVFRS-FELSPYDDIIKAHLNPIDRRVKSVAAKNGCRIAIDGPI--NSYDPLSCQAFRN--KVTYRCTVAGPNKENLDKCMNYLKETFPNTFL 2431 K +R F++ +D+I+K+ P DRR+++V ++ C+I + GP + D S +F N + Y + KE LDK + ++ETFP L Sbjct: 424 MKCYRKCFQVQQFDEIVKSFNTPSDRRMRAVCSRVNCQIKLFGPTSRSQVDSKSHISFVNHEQPLYHLLIFTKTKEQLDKSLKCIQETFPKACL 517 The following BLAST results are available for this feature:
BLAST of Uro-adherence factor A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Uro-adherence factor A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Uro-adherence factor A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Uro-adherence factor A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Uro-adherence factor A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Uro-adherence factor A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Uro-adherence factor A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Uro-adherence factor A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Uro-adherence factor A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Uro-adherence factor A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Uro-adherence factor A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Uro-adherence factor A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Uro-adherence factor A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Uro-adherence factor A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029236 ID=SMED30029236|Name=Uro-adherence factor A|organism=Schmidtea mediterranea sexual|type=transcript|length=2629bpback to top protein sequence of SMED30029236-orf-1 >SMED30029236-orf-1 ID=SMED30029236-orf-1|Name=SMED30029236-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=784bp MIFINNNNTQSDKYFHDNKSQISNKTYFKRLTNSNQEYIGSNDPDYSNFLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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