Homeodomain protein

Overview


Name	Homeodomain protein
Smed ID	SMED30029233
Length (bp)	1174

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Homeodomain protein (SMED30029233) t-SNE clustered cells

Violin plots show distribution of expression levels for Homeodomain protein (SMED30029233) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Homeodomain protein (SMED30029233) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Homeodomain protein (SMED30029233) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30029233

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
central nervous system	SMED30029233	SMESG000043155.1	SMED30029233	smed_20140614	PMID:27034770 Currie et al., 2016
neoblast	SMED30029233	SMESG000043155.1	SMED30029233	smed_20140614	PMID:27034770 Currie et al., 2016
central nervous system	SMED30029233	SMESG000043155.1	SmedASXL_005553	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
central nervous system	SMED30029233	SMESG000043155.1	SmedASXL_005553	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
head region	SMED30029233	SMESG000043155.1	SmedASXL_005553	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
neoblast	SMED30029233	SMESG000043155.1	SmedASXL_005553	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
neoblast	SMED30029233	SMESG000043155.1	SmedASXL_005553	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
Smed sexual biotype	SMED30029233	SMESG000043155.1	Contig53706	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30029233	SMESG000043155.1	Contig53706	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
head region	SMED30029233	SMESG000043155.1	dd_Smed_v6_24257_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Homeodomain protein vs. Ensembl Human
Match: HOXA7 (homeobox A7 [Source:HGNC Symbol;Acc:HGNC:5108])

HSP 1 Score: 123.25 bits (308), Expect = 2.028e-32
Identity = 56/74 (75.68%), Postives = 64/74 (86.49%), Query Frame = 1

Query:  742 QIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +I+PWM   GP+   ++RGRQTY+R+QTLELEKEF FN YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  118 RIYPWMRSSGPD---RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 188

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BLAST of Homeodomain protein vs. Ensembl Human
Match: HOXB7 (homeobox B7 [Source:HGNC Symbol;Acc:HGNC:5118])

HSP 1 Score: 120.553 bits (301), Expect = 1.697e-31
Identity = 54/74 (72.97%), Postives = 62/74 (83.78%), Query Frame = 1

Query:  742 QIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +I+PWM   G     ++RGRQTY+R+QTLELEKEF +N YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  125 RIYPWMRSSG---TDRKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKE 195

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BLAST of Homeodomain protein vs. Ensembl Human
Match: HOXC6 (homeobox C6 [Source:HGNC Symbol;Acc:HGNC:5128])

HSP 1 Score: 114.39 bits (285), Expect = 6.010e-30
Identity = 56/79 (70.89%), Postives = 63/79 (79.75%), Query Frame = 1

Query:  742 QIWPWMTVVGPNS-----VQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            QI+PWM  +  +S       +RRGRQ YSR+QTLELEKEF FN YLTRRRRIEIA+ LCL+ERQIKIWFQNRRMK KKE
Sbjct:   39 QIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKE 117

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BLAST of Homeodomain protein vs. Ensembl Human
Match: HOXC6 (homeobox C6 [Source:HGNC Symbol;Acc:HGNC:5128])

HSP 1 Score: 116.316 bits (290), Expect = 8.470e-30
Identity = 56/79 (70.89%), Postives = 63/79 (79.75%), Query Frame = 1

Query:  742 QIWPWMTVVGPNS-----VQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            QI+PWM  +  +S       +RRGRQ YSR+QTLELEKEF FN YLTRRRRIEIA+ LCL+ERQIKIWFQNRRMK KKE
Sbjct:  121 QIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKE 199

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BLAST of Homeodomain protein vs. Ensembl Human
Match: HOXB6 (homeobox B6 [Source:HGNC Symbol;Acc:HGNC:5117])

HSP 1 Score: 115.931 bits (289), Expect = 9.971e-30
Identity = 55/81 (67.90%), Postives = 63/81 (77.78%), Query Frame = 1

Query:  745 IWPWM--------TVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            ++PWM        +  GP+    RRGRQTY+R+QTLELEKEF +N YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  127 VYPWMQRMNSCNSSSFGPSG---RRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 204

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BLAST of Homeodomain protein vs. Ensembl Celegans
Match: mab-5 (Homeobox protein mab-5 [Source:UniProtKB/Swiss-Prot;Acc:P10038])

HSP 1 Score: 103.605 bits (257), Expect = 7.546e-26
Identity = 47/76 (61.84%), Postives = 59/76 (77.63%), Query Frame = 1

Query:  736 AQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +Q ++PWM + G    + +R RQTYSR QTLELEKEF ++ YLTR+RR EI+  L L+ERQ+KIWFQNRRMK KKE
Sbjct:  100 SQPVFPWMKMGGAKGGESKRTRQTYSRSQTLELEKEFHYHKYLTRKRRQEISETLHLTERQVKIWFQNRRMKHKKE 175

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BLAST of Homeodomain protein vs. Ensembl Celegans
Match: lin-39 (Homeobox protein lin-39 [Source:UniProtKB/Swiss-Prot;Acc:P34684])

HSP 1 Score: 100.138 bits (248), Expect = 4.232e-24
Identity = 49/81 (60.49%), Postives = 61/81 (75.31%), Query Frame = 1

Query:  730 GGAQQIWPWMTVV---GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            GGA  ++PWMT V      S  ++R R  Y+R+Q LELEKEF  + YLTR+RRIE+AH+L L+ERQ+KIWFQNRRMK KKE
Sbjct:  145 GGA--VYPWMTRVHSTTGGSRGEKRQRTAYTRNQVLELEKEFHTHKYLTRKRRIEVAHSLMLTERQVKIWFQNRRMKHKKE 223

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Query:  730 GGAQQIWPWMTVV---GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            GGA  ++PWMT V      S  ++R R  Y+R+Q LELEKEF  + YLTR+RRIE+AH+L L+ERQ+KIWFQNRRMK KKE
Sbjct:  145 GGA--VYPWMTRVHSTTGGSRGEKRQRTAYTRNQVLELEKEFHTHKYLTRKRRIEVAHSLMLTERQVKIWFQNRRMKHKKE 223

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BLAST of Homeodomain protein vs. Ensembl Celegans
Match: php-3 (Posterior Hox gene Paralog [Source:UniProtKB/TrEMBL;Acc:Q9XW88])

HSP 1 Score: 82.0333 bits (201), Expect = 1.818e-17
Identity = 35/62 (56.45%), Postives = 51/62 (82.26%), Query Frame = 1

Query:  790 RRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQI 975
            R+ R+ Y++ QTLELEKEF +N Y+++++R E+A  L L+ERQ+KIWFQNRRMK KK++Q+ 
Sbjct:  200 RKKRKPYTKAQTLELEKEFLYNTYVSKQKRWELAKYLHLTERQVKIWFQNRRMKDKKQKQRT 261

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Query:  790 RRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQI 975
            R+ R+ Y++ QTLELEKEF +N Y+++++R E+A  L L+ERQ+KIWFQNRRMK KK++Q+ 
Sbjct:  200 RKKRKPYTKAQTLELEKEFLYNTYVSKQKRWELAKYLHLTERQVKIWFQNRRMKDKKQKQRT 261

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BLAST of Homeodomain protein vs. Ensembl Fly
Match: Ubx (gene:FBgn0003944 transcript:FBtr0083348)

HSP 1 Score: 137.502 bits (345), Expect = 7.655e-37
Identity = 61/81 (75.31%), Postives = 70/81 (86.42%), Query Frame = 1

Query:  745 IWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELN 987
             +PWM + G N + +RRGRQTY+R+QTLELEKEF  NHYLTRRRRIE+AH LCL+ERQIKIWFQNRRMKLKKE Q I+ELN
Sbjct:  239 FYPWMAIAGTNGL-RRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELN 318

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BLAST of Homeodomain protein vs. Ensembl Fly
Match: abd-A (gene:FBgn0000014 transcript:FBtr0306337)

HSP 1 Score: 134.42 bits (337), Expect = 6.649e-36
Identity = 63/101 (62.38%), Postives = 74/101 (73.27%), Query Frame = 1

Query:  748 WPWMTVV----------------GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITR 1002
            +PWMT+                 GPN   +RRGRQTY+R QTLELEKEF FNHYLTRRRRIEIAH LCL+ERQIKIWFQNRRMKLKKE + ++E+N++  R
Sbjct:  109 YPWMTLTDWMGSPFERVVCGDFNGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARR 209

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BLAST of Homeodomain protein vs. Ensembl Fly
Match: abd-A (gene:FBgn0000014 transcript:FBtr0083387)

HSP 1 Score: 134.42 bits (337), Expect = 6.649e-36
Identity = 63/101 (62.38%), Postives = 74/101 (73.27%), Query Frame = 1

Query:  748 WPWMTVV----------------GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITR 1002
            +PWMT+                 GPN   +RRGRQTY+R QTLELEKEF FNHYLTRRRRIEIAH LCL+ERQIKIWFQNRRMKLKKE + ++E+N++  R
Sbjct:  109 YPWMTLTDWMGSPFERVVCGDFNGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARR 209

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BLAST of Homeodomain protein vs. Ensembl Fly
Match: abd-A (gene:FBgn0000014 transcript:FBtr0300485)

HSP 1 Score: 134.42 bits (337), Expect = 6.649e-36
Identity = 63/101 (62.38%), Postives = 74/101 (73.27%), Query Frame = 1

Query:  748 WPWMTVV----------------GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITR 1002
            +PWMT+                 GPN   +RRGRQTY+R QTLELEKEF FNHYLTRRRRIEIAH LCL+ERQIKIWFQNRRMKLKKE + ++E+N++  R
Sbjct:  109 YPWMTLTDWMGSPFERVVCGDFNGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARR 209

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BLAST of Homeodomain protein vs. Ensembl Fly
Match: abd-A (gene:FBgn0000014 transcript:FBtr0083388)

HSP 1 Score: 136.346 bits (342), Expect = 5.300e-35
Identity = 63/101 (62.38%), Postives = 74/101 (73.27%), Query Frame = 1

Query:  748 WPWMTVV----------------GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITR 1002
            +PWMT+                 GPN   +RRGRQTY+R QTLELEKEF FNHYLTRRRRIEIAH LCL+ERQIKIWFQNRRMKLKKE + ++E+N++  R
Sbjct:  369 YPWMTLTDWMGSPFERVVCGDFNGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARR 469

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BLAST of Homeodomain protein vs. Ensembl Zebrafish
Match: hoxb7a (homeobox B7a [Source:NCBI gene;Acc:58044])

HSP 1 Score: 121.324 bits (303), Expect = 7.564e-32
Identity = 55/74 (74.32%), Postives = 63/74 (85.14%), Query Frame = 1

Query:  742 QIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +I+PWM   G +   ++RGRQTYSR+QTLELEKEF FN YL+RRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  133 RIYPWMRSTGAD---RKRGRQTYSRYQTLELEKEFHFNRYLSRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 203

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BLAST of Homeodomain protein vs. Ensembl Zebrafish
Match: hoxc6b (homeobox C6b [Source:NCBI gene;Acc:58045])

HSP 1 Score: 120.553 bits (301), Expect = 1.351e-31
Identity = 60/90 (66.67%), Postives = 68/90 (75.56%), Query Frame = 1

Query:  733 GAQQIWPWMTVVGPNSV----QKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELND 990
            G+ QI+PWM  +  + V     +RRGRQ YSR+QTLELEKEF +N YLTRRRRIEIA+ LCLSERQIKIWFQNRRMK KKE      LND
Sbjct:  113 GSVQIYPWMQRMNSHRVGYGSDRRRGRQIYSRYQTLELEKEFHYNRYLTRRRRIEIANTLCLSERQIKIWFQNRRMKWKKESNLTSILND 202

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BLAST of Homeodomain protein vs. Ensembl Zebrafish
Match: hoxc6b (homeobox C6b [Source:NCBI gene;Acc:58045])

HSP 1 Score: 120.168 bits (300), Expect = 1.989e-31
Identity = 60/91 (65.93%), Postives = 68/91 (74.73%), Query Frame = 1

Query:  733 GAQQIWPWMTVVGPNS-----VQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELND 990
            G+ QI+PWM  +  +S       +RRGRQ YSR+QTLELEKEF +N YLTRRRRIEIA+ LCLSERQIKIWFQNRRMK KKE      LND
Sbjct:  113 GSVQIYPWMQRMNSHSGVGYGSDRRRGRQIYSRYQTLELEKEFHYNRYLTRRRRIEIANTLCLSERQIKIWFQNRRMKWKKESNLTSILND 203

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BLAST of Homeodomain protein vs. Ensembl Zebrafish
Match: hoxc6b (homeobox C6b [Source:NCBI gene;Acc:58045])

HSP 1 Score: 119.398 bits (298), Expect = 2.208e-31
Identity = 60/91 (65.93%), Postives = 68/91 (74.73%), Query Frame = 1

Query:  733 GAQQIWPWMTVVGPNS-----VQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELND 990
            G+ QI+PWM  +  +S       +RRGRQ YSR+QTLELEKEF +N YLTRRRRIEIA+ LCLSERQIKIWFQNRRMK KKE      LND
Sbjct:   98 GSVQIYPWMQRMNSHSGVGYGSDRRRGRQIYSRYQTLELEKEFHYNRYLTRRRRIEIANTLCLSERQIKIWFQNRRMKWKKESNLTSILND 188

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BLAST of Homeodomain protein vs. Ensembl Zebrafish
Match: hoxb6a (homeobox B6a [Source:NCBI gene;Acc:30341])

HSP 1 Score: 117.472 bits (293), Expect = 2.162e-30
Identity = 56/81 (69.14%), Postives = 63/81 (77.78%), Query Frame = 1

Query:  745 IWPWM----TVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQI 975
            ++PWM    +  G      RRGRQTY+R+QTLELEKEF FN YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE + I
Sbjct:  132 VYPWMQRMNSCNGTFGNAGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKLI 212

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BLAST of Homeodomain protein vs. Ensembl Xenopus
Match: cd276 (CD276 molecule [Source:Xenbase;Acc:XB-GENE-921537])

HSP 1 Score: 123.635 bits (309), Expect = 6.805e-33
Identity = 56/77 (72.73%), Postives = 66/77 (85.71%), Query Frame = 1

Query:  742 QIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQ 972
            +I+PWM   GP+   ++RGRQTY+R+QTLELEKEF FN YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE ++
Sbjct:  109 RIYPWMRSSGPD---RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHKE 182

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BLAST of Homeodomain protein vs. Ensembl Xenopus
Match: HOXB7 (homeobox B7 [Source:NCBI gene;Acc:100494663])

HSP 1 Score: 121.709 bits (304), Expect = 4.892e-32
Identity = 55/74 (74.32%), Postives = 62/74 (83.78%), Query Frame = 1

Query:  742 QIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +I+PWM   G     ++RGRQTY+R+QTLELEKEF FN YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  124 RIYPWMRSTG---ADRKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 194

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BLAST of Homeodomain protein vs. Ensembl Xenopus
Match: HOXB6 (homeobox B6 [Source:NCBI gene;Acc:100124320])

HSP 1 Score: 120.168 bits (300), Expect = 2.348e-31
Identity = 58/84 (69.05%), Postives = 66/84 (78.57%), Query Frame = 1

Query:  736 AQQIWPWM--------TVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            A  ++PWM        +V GP+    RRGRQTY+R+QTLELEKEF FN YLTRRRRIEIAH+LCL+ERQIKIWFQNRRMK KKE
Sbjct:  123 ATPVYPWMQRMNSCNSSVFGPSG---RRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHSLCLTERQIKIWFQNRRMKWKKE 203

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BLAST of Homeodomain protein vs. Ensembl Xenopus
Match: zdhhc15 (zinc finger DHHC-type containing 15 [Source:Xenbase;Acc:XB-GENE-948859])

HSP 1 Score: 118.627 bits (296), Expect = 1.057e-30
Identity = 57/82 (69.51%), Postives = 65/82 (79.27%), Query Frame = 1

Query:  733 GAQQIWPWMTVVGPNS-----VQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            G+ QI+PWM  +  +S       +RRGRQ YSR+QTLELEKEF FN YLTRRRRIEIA+ LCL+ERQIKIWFQNRRMK KKE
Sbjct:  118 GSIQIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKE 199

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BLAST of Homeodomain protein vs. Ensembl Xenopus
Match: aldh7a1 (aldehyde dehydrogenase 7 family member A1 [Source:Xenbase;Acc:XB-GENE-492001])

HSP 1 Score: 114.775 bits (286), Expect = 3.884e-29
Identity = 55/78 (70.51%), Postives = 61/78 (78.21%), Query Frame = 1

Query:  745 IWPWM----TVVGP-NSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            ++PWM    +  GP      RRGRQTY+R QTLELEKEF FN YLTRRRRIEIA+ LCL+ERQIKIWFQNRRMK KKE
Sbjct:  136 VYPWMQRVNSCTGPVYGAHGRRGRQTYTRFQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKE 213

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BLAST of Homeodomain protein vs. Ensembl Mouse
Match: Hoxa7 (homeobox A7 [Source:MGI Symbol;Acc:MGI:96179])

HSP 1 Score: 124.79 bits (312), Expect = 3.946e-33
Identity = 56/76 (73.68%), Postives = 65/76 (85.53%), Query Frame = 1

Query:  742 QIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQ 969
            +I+PWM   GP+   ++RGRQTY+R+QTLELEKEF FN YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE +
Sbjct:  117 RIYPWMRSSGPD---RKRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHK 189

[Close]

BLAST of Homeodomain protein vs. Ensembl Mouse
Match: Hoxb7 (homeobox B7 [Source:MGI Symbol;Acc:MGI:96188])

HSP 1 Score: 123.635 bits (309), Expect = 7.525e-33
Identity = 55/74 (74.32%), Postives = 64/74 (86.49%), Query Frame = 1

Query:  742 QIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +I+PWM   GP+   ++RGRQTY+R+QTLELEKEF +N YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  125 RIYPWMRSSGPD---RKRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHTLCLTERQIKIWFQNRRMKWKKE 195

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BLAST of Homeodomain protein vs. Ensembl Mouse
Match: Hoxb6 (homeobox B6 [Source:MGI Symbol;Acc:MGI:96187])

HSP 1 Score: 116.316 bits (290), Expect = 5.129e-30
Identity = 55/81 (67.90%), Postives = 63/81 (77.78%), Query Frame = 1

Query:  745 IWPWM--------TVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            ++PWM        +  GP+    RRGRQTY+R+QTLELEKEF +N YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  127 VYPWMQRMNSCNSSSFGPSG---RRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 204

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Query:  745 IWPWM--------TVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            ++PWM        +  GP+    RRGRQTY+R+QTLELEKEF +N YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  127 VYPWMQRMNSCNSSSFGPSG---RRGRQTYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 204

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BLAST of Homeodomain protein vs. Ensembl Mouse
Match: Hoxc6 (homeobox C6 [Source:MGI Symbol;Acc:MGI:96197])

HSP 1 Score: 116.316 bits (290), Expect = 5.815e-30
Identity = 56/79 (70.89%), Postives = 63/79 (79.75%), Query Frame = 1

Query:  742 QIWPWMTVVGPNS-----VQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            QI+PWM  +  +S       +RRGRQ YSR+QTLELEKEF FN YLTRRRRIEIA+ LCL+ERQIKIWFQNRRMK KKE
Sbjct:  121 QIYPWMQRMNSHSGVGYGADRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKE 199

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BLAST of Homeodomain protein vs. UniProt/SwissProt
Match: sp|Q01622|HLOX2_HELRO (Homeobox protein LOX2 (Fragment) OS=Helobdella robusta OX=6412 GN=LOX2 PE=2 SV=1)

HSP 1 Score: 142.895 bits (359), Expect = 3.119e-37
Identity = 67/93 (72.04%), Postives = 79/93 (84.95%), Query Frame = 1

Query:  733 GAQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTI 1011
            G+   +PWM++VGPNS Q+RRGRQTY+R+QTLELEKEF+FN YLTRRRRIE++H L L+ERQIKIWFQNRRMK KKE Q IRELN EI +  I
Sbjct:  199 GSAPSYPWMSIVGPNSNQRRRGRQTYTRYQTLELEKEFKFNRYLTRRRRIELSHTLYLTERQIKIWFQNRRMKEKKEVQAIRELN-EIEKTKI 290

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BLAST of Homeodomain protein vs. UniProt/SwissProt
Match: sp|Q8T940|UBX_JUNCO (Homeotic protein ultrabithorax OS=Junonia coenia OX=39708 GN=Ubx PE=2 SV=1)

HSP 1 Score: 135.961 bits (341), Expect = 3.363e-36
Identity = 61/83 (73.49%), Postives = 72/83 (86.75%), Query Frame = 1

Query:  745 IWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDE 993
             +PWM + G N + +RRGRQTY+R+QTLELEKEF  NHYLTRRRRIE+AH LCL+ERQIKIWFQNRRMKLKKE Q I+ELN++
Sbjct:  146 FYPWMAIAGANGL-RRRGRQTYTRYQTLELEKEFHTNHYLTRRRRIEMAHALCLTERQIKIWFQNRRMKLKKEIQAIKELNEQ 227

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BLAST of Homeodomain protein vs. UniProt/SwissProt
Match: sp|P15856|ABDA_APIME (Homeobox protein abdominal-A homolog (Fragment) OS=Apis mellifera OX=7460 GN=ABD-A PE=3 SV=1)

HSP 1 Score: 126.331 bits (316), Expect = 7.677e-35
Identity = 57/73 (78.08%), Postives = 65/73 (89.04%), Query Frame = 1

Query:  769 GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELN 987
            GPN   +RRGRQTY+R QTLELEKEF +NHYLTRRRRIEIAH LCL+ERQIKIWFQNRRMKLKKE + ++E+N
Sbjct:    2 GPNGCPRRRGRQTYTRFQTLELEKEFHYNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEIN 74

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BLAST of Homeodomain protein vs. UniProt/SwissProt
Match: sp|Q07961|ABDA_TRICA (Homeobox protein abdominal-A homolog OS=Tribolium castaneum OX=7070 GN=ABD-A PE=2 SV=2)

HSP 1 Score: 134.035 bits (336), Expect = 1.431e-34
Identity = 62/91 (68.13%), Postives = 71/91 (78.02%), Query Frame = 1

Query:  748 WPWMT-----------VVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELN 987
            +PWM+           V GPN   +RRGRQTY+R QTLELEKEF FNHYLTRRRRIEIAH LCL+ERQIKIWFQNRRMKLKKE + ++E+N
Sbjct:  192 YPWMSITDWMSPFDRVVCGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEIN 282

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BLAST of Homeodomain protein vs. UniProt/SwissProt
Match: sp|O76762|ABDA_ANOGA (Homeobox protein abdominal-A homolog OS=Anopheles gambiae OX=7165 GN=abd-A PE=2 SV=1)

HSP 1 Score: 132.88 bits (333), Expect = 1.775e-34
Identity = 59/80 (73.75%), Postives = 69/80 (86.25%), Query Frame = 1

Query:  766 VGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRK 1005
             GPN   +RRGRQTY+R QTLELEKEF FNHYLTRRRRIEIAH LCL+ERQIKIWFQNRRMKLKKE + ++E+N++  R+
Sbjct:  131 AGPNGCPRRRGRQTYTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELRAVKEINEQARRE 210

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BLAST of Homeodomain protein vs. TrEMBL
Match: P91714 (Homeodomain protein OS=Girardia tigrina OX=6162 GN=DthoxF PE=2 SV=2)

HSP 1 Score: 407.912 bits (1047), Expect = 1.524e-137
Identity = 236/398 (59.30%), Postives = 271/398 (68.09%), Query Frame = 1

Query:  205 MKNDFLATISNNFTVESFDKCNKSHLPELFTRGISSGVDDSCKMMNQNTFWSSNMPHLMAAAAVGG--------------------------HYPPFPVTSVMAGVDQ-----------------------------------------KNLPQIDIDLHSDPVLSDSHQGCLPLSHTFPXXXXXXXXXXXXXXXXIGLYSNYPNQMQSIDELDDDKFDMDCPLRNDQKYTDXXXXXXXXXXGGAQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKHLSSNYNWESVSVSSGGADDESYGLVNMSAPVN--------IMGQQ*SQ*IIFICNTCC 1173
            MKN+FLA+ISNNF V SFDK  KSHLP+LFTRGISSGVD SCKMMNQNT         + A AVGG                          H P      + +GVD+                                         K+L QID+DLHSD V+ DSHQ C+ L H FP+ NNN +SLSSFN+FAIGLYSNYPNQ+Q+IDE+ DDKF++DC +R++QK+ +NE NS +R++GGAQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKHLSSNYNWESVSVS  G D ES GLVN S+ VN        ++GQ  ++ ++  C+ C 
Sbjct:    1 MKNNFLASISNNFGVNSFDKYGKSHLPKLFTRGISSGVDKSCKMMNQNTVLVKWYALQLMATAVGGHYPAFPGRLLLWPGSNRDSFDKYGKSHLPELFTKGISSGVDESSQNDESDTFWSKWYASVNGSGLGVVIILHFRSVCYGRVEPKHLSQIDLDLHSDQVIPDSHQACMSLPHAFPNNNNNTSSLSSFNTFAIGLYSNYPNQIQNIDEIGDDKFEIDCSMRSEQKFNENETNSGTRNDGGAQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKHLSSNYNWESVSVSK-GPDHESGGLVNFSSLVNKTRQLLSLLIGQLPNKYLLIFCSFCV 397

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BLAST of Homeodomain protein vs. TrEMBL
Match: Q26081 (Homeodomain protein (Fragment) OS=Polycelis nigra OX=39786 GN=Pnox1 a PE=4 SV=1)

HSP 1 Score: 172.17 bits (435), Expect = 1.860e-49
Identity = 84/93 (90.32%), Postives = 88/93 (94.62%), Query Frame = 1

Query:  772 PNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKH-LSSNYNWE 1047
            PNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQI+ELNDE++RK  SKK  +S NYNWE
Sbjct:    1 PNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIQELNDELSRKVKSKKQNMSVNYNWE 93

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BLAST of Homeodomain protein vs. TrEMBL
Match: A0A068Y797 (Homeodomain protein OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000824700 PE=4 SV=1)

HSP 1 Score: 180.644 bits (457), Expect = 2.018e-49
Identity = 80/98 (81.63%), Postives = 92/98 (93.88%), Query Frame = 1

Query:  730 GGAQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKH 1023
            G  +QIWPWMTVVGPNSVQ+RRGRQTYSR QTLELEKEFQ++HYLTRRRRIEIAH+LCL+ERQIKIWFQNRRMKLKKERQQI++LNDE+ R+ +S+ H
Sbjct:  204 GSMEQIWPWMTVVGPNSVQRRRGRQTYSRFQTLELEKEFQYSHYLTRRRRIEIAHSLCLTERQIKIWFQNRRMKLKKERQQIKDLNDEMNRRIMSESH 301

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BLAST of Homeodomain protein vs. TrEMBL
Match: A0A068WDW5 (Homeodomain protein OS=Echinococcus granulosus OX=6210 GN=EgrG_000824700 PE=4 SV=1)

HSP 1 Score: 180.259 bits (456), Expect = 2.741e-49
Identity = 80/98 (81.63%), Postives = 92/98 (93.88%), Query Frame = 1

Query:  730 GGAQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKH 1023
            G  +QIWPWMTVVGPNSVQ+RRGRQTYSR QTLELEKEFQ++HYLTRRRRIEIAH+LCL+ERQIKIWFQNRRMKLKKERQQI++LNDE+ R+ +S+ H
Sbjct:  208 GSMEQIWPWMTVVGPNSVQRRRGRQTYSRFQTLELEKEFQYSHYLTRRRRIEIAHSLCLTERQIKIWFQNRRMKLKKERQQIKDLNDEMNRRIMSESH 305

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BLAST of Homeodomain protein vs. TrEMBL
Match: A0A158QEJ7 (Homeobox domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS7526 PE=4 SV=1)

HSP 1 Score: 173.711 bits (439), Expect = 1.752e-47
Identity = 78/97 (80.41%), Postives = 92/97 (94.85%), Query Frame = 1

Query:  739 QQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTI--SKKH 1023
            +QIWPWMTVVGPNSVQ+RRGRQTYSR QTLELEKEFQ++HYLTRRRR+EIAH+LCL+ERQIKIWFQNRRMKLKKERQQI++LN+E+ R+ +  S+KH
Sbjct:  154 EQIWPWMTVVGPNSVQRRRGRQTYSRFQTLELEKEFQYSHYLTRRRRVEIAHSLCLTERQIKIWFQNRRMKLKKERQQIKDLNEEMNRRLMNESQKH 250

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BLAST of Homeodomain protein vs. Ensembl Cavefish
Match: hoxb7a (homeobox B7 [Source:NCBI gene;Acc:103045369])

HSP 1 Score: 122.094 bits (305), Expect = 3.580e-32
Identity = 56/74 (75.68%), Postives = 63/74 (85.14%), Query Frame = 1

Query:  742 QIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +I+PWM   G +   ++RGRQTYSR+QTLELEKEF FN YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  135 RIYPWMRSTGAD---RKRGRQTYSRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 205

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BLAST of Homeodomain protein vs. Ensembl Cavefish
Match: hoxb6a (homeobox protein Hox-B6a [Source:NCBI gene;Acc:103045875])

HSP 1 Score: 116.701 bits (291), Expect = 3.374e-30
Identity = 56/81 (69.14%), Postives = 63/81 (77.78%), Query Frame = 1

Query:  745 IWPWM----TVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQI 975
            ++PWM    +  G      RRGRQTY+R+QTLELEKEF FN YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE + I
Sbjct:  130 VYPWMQRMNSCNGTFGNPGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKENKLI 210

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BLAST of Homeodomain protein vs. Ensembl Cavefish
Match: hoxc6a (homeobox C6 [Source:NCBI gene;Acc:103034651])

HSP 1 Score: 115.931 bits (289), Expect = 6.367e-30
Identity = 57/82 (69.51%), Postives = 64/82 (78.05%), Query Frame = 1

Query:  733 GAQQIWPWMTVVGPNS-----VQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            G  QI+PWM  +  +S       +RRGRQ YSR+QTLELEKEF FN YLTRRRRIEIA+ LCL+ERQIKIWFQNRRMK KKE
Sbjct:  118 GNIQIYPWMQRMNSHSGVGYGSDRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKE 199

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BLAST of Homeodomain protein vs. Ensembl Cavefish
Match: hoxb6b (homeobox protein Hox-B6b [Source:NCBI gene;Acc:103030519])

HSP 1 Score: 113.62 bits (283), Expect = 3.118e-29
Identity = 54/77 (70.13%), Postives = 60/77 (77.92%), Query Frame = 1

Query:  745 IWPWM----TVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            ++PWM    +  G      RRGRQTY+R QTLELEKEF FN YLTRRRRIEI+H LCL+ERQIKIWFQNRRMK KKE
Sbjct:  121 VYPWMQRMNSCNGIPGNTGRRGRQTYTRFQTLELEKEFHFNRYLTRRRRIEISHALCLTERQIKIWFQNRRMKWKKE 197

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BLAST of Homeodomain protein vs. Ensembl Cavefish
Match: hoxb5a (homeobox protein Hox-B5a [Source:NCBI gene;Acc:111192049])

HSP 1 Score: 114.775 bits (286), Expect = 5.399e-29
Identity = 56/85 (65.88%), Postives = 63/85 (74.12%), Query Frame = 1

Query:  730 GGAQQIWPWMT-------VVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            G A QI+PWM        + GP+    +R R  Y+R+QTLELEKEF FN YLTRRRRIEIAH LCLSERQIKIWFQNRRMK KK+
Sbjct:  177 GQAPQIFPWMRKLHISHDMTGPDG---KRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKD 258

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BLAST of Homeodomain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005057.1 (pep scaffold:Pmarinus_7.0:GL483321:9136:13526:-1 gene:ENSPMAG00000004598.1 transcript:ENSPMAT00000005057.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 108.612 bits (270), Expect = 1.712e-29
Identity = 53/73 (72.60%), Postives = 61/73 (83.56%), Query Frame = 1

Query:  745 IWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            ++PWM   GP    +RRGRQTYSR+QTLELEKEF FN YLTR+RRIE++H L LSERQ+KIWFQNRRMK KKE
Sbjct:   16 VFPWMRPQGP---ARRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHVLGLSERQVKIWFQNRRMKWKKE 85

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BLAST of Homeodomain protein vs. Ensembl Sea Lamprey
Match: hoxb7a (homeobox B7a [Source:NCBI gene;Acc:58044])

HSP 1 Score: 106.686 bits (265), Expect = 4.613e-29
Identity = 50/58 (86.21%), Postives = 55/58 (94.83%), Query Frame = 1

Query:  790 RRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +RGRQTYSR+QTLELEKEF FN YLTRRRR+EIAH+LCL+ERQIKIWFQNRRMK KKE
Sbjct:    5 KRGRQTYSRYQTLELEKEFHFNRYLTRRRRVEIAHSLCLTERQIKIWFQNRRMKWKKE 62

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BLAST of Homeodomain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011116.1 (pep scaffold:Pmarinus_7.0:GL482944:7995:8174:-1 gene:ENSPMAG00000010089.1 transcript:ENSPMAT00000011116.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 105.916 bits (263), Expect = 6.698e-29
Identity = 48/59 (81.36%), Postives = 55/59 (93.22%), Query Frame = 1

Query:  790 RRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKER 966
            R+GR++YSRHQ+LELEKEF FN YL RRRR+EIAH+LCLSERQ+KIWFQNRRMK KKER
Sbjct:    2 RKGRRSYSRHQSLELEKEFHFNRYLARRRRVEIAHSLCLSERQVKIWFQNRRMKWKKER 60

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BLAST of Homeodomain protein vs. Ensembl Sea Lamprey
Match: hoxd4a (homeobox D4a [Source:NCBI gene;Acc:30329])

HSP 1 Score: 97.8265 bits (242), Expect = 1.510e-25
Identity = 46/58 (79.31%), Postives = 50/58 (86.21%), Query Frame = 1

Query:  790 RRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +R R  Y+R Q LELEKEF FN YLTRRRRIEIAH+LCLSERQIKIWFQNRRMK KK+
Sbjct:    3 KRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHSLCLSERQIKIWFQNRRMKWKKD 60

[Close]

BLAST of Homeodomain protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011242.1 (pep scaffold:Pmarinus_7.0:GL476758:607601:607780:-1 gene:ENSPMAG00000010215.1 transcript:ENSPMAT00000011242.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 85.1149 bits (209), Expect = 3.512e-21
Identity = 41/59 (69.49%), Postives = 47/59 (79.66%), Query Frame = 1

Query:  790 RRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKER 966
            R+ R  YS+ QTLELEKEF FN YLTR RR E+A  L L+ERQ+KIWFQNRRMKLKK +
Sbjct:    2 RKKRCPYSKQQTLELEKEFLFNMYLTRDRRYEVARGLNLTERQVKIWFQNRRMKLKKMK 60

[Close]

BLAST of Homeodomain protein vs. Ensembl Yeast
Match: YOX1 (Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; phosphorylated by Cdc28p; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication [Source:SGD;Acc:S000004489])

HSP 1 Score: 48.1358 bits (113), Expect = 1.154e-6
Identity = 23/77 (29.87%), Postives = 45/77 (58.44%), Query Frame = 1

Query:  736 AQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKER 966
            +Q+ +P       N+   RR R+  S  +   L+ EF+     ++ +RIE+A +  ++E+ ++IWFQN+R  +K++R
Sbjct:  159 SQETFPKKEPKIDNAPLARRKRRRTSSQELSILQAEFEKCPAPSKEKRIELAESCHMTEKAVQIWFQNKRQAVKRQR 235

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BLAST of Homeodomain protein vs. Ensembl Nematostella
Match: ANTHOX7 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S272])

HSP 1 Score: 83.9593 bits (206), Expect = 8.405e-19
Identity = 41/83 (49.40%), Postives = 54/83 (65.06%), Query Frame = 1

Query:  739 QQIWPWMTVV-----GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQ 972
            Q I+PWM        G      +R R +Y+  Q LELEKEF +N YL   RR E+A+ + L+ERQ+K+WFQNRRMKLKK+ +Q
Sbjct:   78 QPIYPWMRTKKSGSRGIGGKHTKRYRTSYTNRQLLELEKEFHYNKYLCGTRRRELANAMKLTERQVKVWFQNRRMKLKKDEKQ 160

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BLAST of Homeodomain protein vs. Ensembl Nematostella
Match: MOXB (MoxB; Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SR28])

HSP 1 Score: 77.0258 bits (188), Expect = 1.321e-17
Identity = 37/64 (57.81%), Postives = 48/64 (75.00%), Query Frame = 1

Query:  769 GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKK 960
              N  +KR+ R  +++HQ  ELE EFQ N+YLTR RR EIA +L L+ERQ+K+WFQNRRMK K+
Sbjct:   10 AKNLGKKRKERTAFTKHQIQELENEFQRNNYLTRLRRYEIAVSLDLTERQVKVWFQNRRMKWKR 73

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BLAST of Homeodomain protein vs. Ensembl Nematostella
Match: EDO45896 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRW6])

HSP 1 Score: 75.8702 bits (185), Expect = 1.371e-17
Identity = 37/57 (64.91%), Postives = 44/57 (77.19%), Query Frame = 1

Query:  793 RGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            + R  YS  Q +ELEKEF +N YL R RRIEIA +L L+E+Q+KIWFQNRRMK KKE
Sbjct:    3 KNRTIYSTRQLVELEKEFHYNRYLCRPRRIEIAQSLELTEKQVKIWFQNRRMKWKKE 59

[Close]

BLAST of Homeodomain protein vs. Ensembl Nematostella
Match: EDO49445 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGM9])

HSP 1 Score: 76.2554 bits (186), Expect = 1.517e-17
Identity = 33/62 (53.23%), Postives = 47/62 (75.81%), Query Frame = 1

Query:  799 RQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIREL 984
            R  ++  Q LE+EKEF ++HY++R RRIEI   L LSE+Q++ WFQNRRMKLK+E + + E+
Sbjct:    1 RSAFTTVQQLEIEKEFLYDHYVSRVRRIEIVMALDLSEKQVRTWFQNRRMKLKREAKNVEEV 62

[Close]

BLAST of Homeodomain protein vs. Ensembl Nematostella
Match: ANTHOX1A.NV (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGM8])

HSP 1 Score: 77.7962 bits (190), Expect = 2.734e-17
Identity = 38/59 (64.41%), Postives = 44/59 (74.58%), Query Frame = 1

Query:  787 KRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            K R R  Y+R Q LELEKEF F  YLT+ RR E+A  L L+ERQ+KIWFQNRRMK KK+
Sbjct:   79 KHRKRMAYTRIQLLELEKEFHFTRYLTKERRTEMARMLDLTERQVKIWFQNRRMKWKKD 137

[Close]

BLAST of Homeodomain protein vs. Ensembl Medaka
Match: hoxb6b (homeobox protein Hox-B6b [Source:NCBI gene;Acc:101164012])

HSP 1 Score: 119.398 bits (298), Expect = 5.565e-31
Identity = 56/78 (71.79%), Postives = 61/78 (78.21%), Query Frame = 1

Query:  745 IWPWM-----TVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            I+PWM        GP     RRGRQTY+R+QTLELEKEF FN YLTRRRRIEI+H LCL+ERQIKIWFQNRRMK KKE
Sbjct:  154 IYPWMQRMNACSAGPFGTSGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEISHALCLTERQIKIWFQNRRMKWKKE 231

[Close]

BLAST of Homeodomain protein vs. Ensembl Medaka
Match: HOXA7 (homeobox A7 [Source:NCBI gene;Acc:110015904])

HSP 1 Score: 115.931 bits (289), Expect = 6.506e-30
Identity = 52/77 (67.53%), Postives = 64/77 (83.12%), Query Frame = 1

Query:  742 QIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQ 972
            +++PWM    PN   ++RGRQTYSR+QTLELEKEF FN YL+RRRR+EIAH L L+ERQIKIWFQNRRMK KK+ ++
Sbjct:  111 RMYPWMQASDPN---RKRGRQTYSRYQTLELEKEFHFNRYLSRRRRVEIAHALTLTERQIKIWFQNRRMKWKKDHKE 184

[Close]

BLAST of Homeodomain protein vs. Ensembl Medaka
Match: ENSORLT00000021318.2 (homeobox protein Hox-B6a [Source:NCBI gene;Acc:101155275])

HSP 1 Score: 115.546 bits (288), Expect = 1.504e-29
Identity = 56/77 (72.73%), Postives = 61/77 (79.22%), Query Frame = 1

Query:  745 IWPWMTVV----GPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            I+PWM  +    G      RRGRQTY+R+QTLELEKEF FN YLTRRRRIEIAH LCL+ERQIKIWFQNRRMK KKE
Sbjct:  156 IYPWMQRMNACNGTFGSPGRRGRQTYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE 232

[Close]

BLAST of Homeodomain protein vs. Ensembl Medaka
Match: hoxc6a (homeobox C6 [Source:NCBI gene;Acc:101173938])

HSP 1 Score: 114.775 bits (286), Expect = 2.188e-29
Identity = 63/119 (52.94%), Postives = 78/119 (65.55%), Query Frame = 1

Query:  745 IWPWMTVVGPNSV------QKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKHLSSNYNWESVSVSSGGADDE 1083
            I+PWM  +  +S        +RRGRQ YSR+QTLELEKEF FN YLTRRRRIEIA+ LCL+ERQIKIWFQNRRMK KKE       ++  +  T S++  +S  N  S +   G  DD+
Sbjct:  121 IYPWMQRMNSHSAGVGYGTDRRRGRQIYSRYQTLELEKEFHFNRYLTRRRRIEIANALCLTERQIKIWFQNRRMKWKKE-------SNLTSTVTGSEQTGASQENERSGATEEGKEDDK 232

[Close]

BLAST of Homeodomain protein vs. Ensembl Medaka
Match: hoxa5a (homeobox A5a [Source:NCBI gene;Acc:58055])

HSP 1 Score: 113.62 bits (283), Expect = 1.976e-28
Identity = 59/115 (51.30%), Postives = 72/115 (62.61%), Query Frame = 1

Query:  640 LDDDKFDMDCPLRNDQKYTDXXXXXXXXXXGGAQQIWPWMT-------VVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            L  D      PL +++      +   + S+    QI+PWM        + GP   + +R R  Y+R+QTLELEKEF FN YLTRRRRIEIAH LCLSERQIKIWFQNRRMK KK+
Sbjct:  173 LSRDCVSKASPLEDEKAAGSAPSTPQNASDSAQPQIYPWMRKLHISHDISGP---EGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKD 284

[Close]

BLAST of Homeodomain protein vs. Planmine SMEST
Match: SMESG000043155.1 (SMESG000043155.1)

HSP 1 Score: 712.605 bits (1838), Expect = 0.000e+0
Identity = 366/366 (100.00%), Postives = 366/366 (100.00%), Query Frame = 1

Query:   37 MMSSCLQQFDANAFIIDNDNPMKTRNFMIENSICDSIRPGYSDLLTDSRTNYHDLAMKNDFLATISNNFTVESFDKCNKSHLPELFTRGISSGVDDSCKMMNQNTFWSSNMPHLMAAAAVGGHYPPFPVTSVMAGVDQKNLPQIDIDLHSDPVLSDSHQGCLPLSHTFPXXXXXXXXXXXXXXXXIGLYSNYPNQMQSIDELDDDKFDMDCPLRNDQKYTDXXXXXXXXXXGGAQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKHLSSNYNWESVSVSSGGADDESYGLVNMSAPVNIMGQQ 1134
            MMSSCLQQFDANAFIIDNDNPMKTRNFMIENSICDSIRPGYSDLLTDSRTNYHDLAMKNDFLATISNNFTVESFDKCNKSHLPELFTRGISSGVDDSCKMMNQNTFWSSNMPHLMAAAAVGGHYPPFPVTSVMAGVDQKNLPQIDIDLHSDPVLSDSHQGCLPLSHTFPSANNNNTSLSSFNSFAIGLYSNYPNQMQSIDELDDDKFDMDCPLRNDQKYTDNENNSNSRSEGGAQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKHLSSNYNWESVSVSSGGADDESYGLVNMSAPVNIMGQQ
Sbjct:    1 MMSSCLQQFDANAFIIDNDNPMKTRNFMIENSICDSIRPGYSDLLTDSRTNYHDLAMKNDFLATISNNFTVESFDKCNKSHLPELFTRGISSGVDDSCKMMNQNTFWSSNMPHLMAAAAVGGHYPPFPVTSVMAGVDQKNLPQIDIDLHSDPVLSDSHQGCLPLSHTFPSANNNNTSLSSFNSFAIGLYSNYPNQMQSIDELDDDKFDMDCPLRNDQKYTDNENNSNSRSEGGAQQIWPWMTVVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELNDEITRKTISKKHLSSNYNWESVSVSSGGADDESYGLVNMSAPVNIMGQQ 366

[Close]

BLAST of Homeodomain protein vs. Planmine SMEST
Match: SMESG000022667.1 (SMESG000022667.1)

HSP 1 Score: 113.235 bits (282), Expect = 1.020e-28
Identity = 54/77 (70.13%), Postives = 60/77 (77.92%), Query Frame = 1

Query:  745 IWPWMT----VVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            ++ WM        PNS   +R RQTY+RHQTLELEKEF FN YLTRRRRIEIAH+L L+ERQIKIWFQNRRMK KKE
Sbjct:  145 LYSWMNPKSGADNPNSSNNKRTRQTYTRHQTLELEKEFHFNKYLTRRRRIEIAHSLILTERQIKIWFQNRRMKWKKE 221

[Close]

BLAST of Homeodomain protein vs. Planmine SMEST
Match: SMESG000044469.1 (SMESG000044469.1)

HSP 1 Score: 105.531 bits (262), Expect = 6.598e-27
Identity = 50/78 (64.10%), Postives = 58/78 (74.36%), Query Frame = 1

Query:  748 WPWMTVVGPN------SVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKE 963
            +PWM            S + +R RQ YSR QTLELEKEF +N YLTRRRRIEIA+++CLSERQIKIWFQNRRMK KK+
Sbjct:   86 FPWMQKSNTRKNKSDRSAEYKRSRQAYSRQQTLELEKEFYYNQYLTRRRRIEIANSVCLSERQIKIWFQNRRMKYKKD 163

[Close]

BLAST of Homeodomain protein vs. Planmine SMEST
Match: SMESG000079807.1 (SMESG000079807.1)

HSP 1 Score: 108.227 bits (269), Expect = 1.985e-26
Identity = 54/83 (65.06%), Postives = 64/83 (77.11%), Query Frame = 1

Query:  745 IWPWMT--VVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELN 987
            ++PWM   +   +S   +R RQTY+R+QTLELEKEF FN YLTRRRRIEIAH L L+ERQIKIWFQNRRMK KK+   I +LN
Sbjct:  197 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD-HNIPKLN 278

[Close]

BLAST of Homeodomain protein vs. Planmine SMEST
Match: SMESG000079807.1 (SMESG000079807.1)

HSP 1 Score: 107.842 bits (268), Expect = 2.580e-26
Identity = 54/83 (65.06%), Postives = 64/83 (77.11%), Query Frame = 1

Query:  745 IWPWMT--VVGPNSVQKRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQNRRMKLKKERQQIRELN 987
            ++PWM   +   +S   +R RQTY+R+QTLELEKEF FN YLTRRRRIEIAH L L+ERQIKIWFQNRRMK KK+   I +LN
Sbjct:  200 VYPWMNPKMNSESSSDHKRSRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALSLTERQIKIWFQNRRMKWKKD-HNIPKLN 281

The following BLAST results are available for this feature:

BLAST of Homeodomain protein vs. Ensembl Human
BLAST of Homeodomain protein vs. Ensembl Celegans
BLAST of Homeodomain protein vs. Ensembl Fly
BLAST of Homeodomain protein vs. Ensembl Zebrafish
BLAST of Homeodomain protein vs. Ensembl Xenopus
BLAST of Homeodomain protein vs. Ensembl Mouse
BLAST of Homeodomain protein vs. UniProt/SwissProt
BLAST of Homeodomain protein vs. TrEMBL
BLAST of Homeodomain protein vs. Ensembl Cavefish
BLAST of Homeodomain protein vs. Ensembl Sea Lamprey
BLAST of Homeodomain protein vs. Ensembl Yeast
BLAST of Homeodomain protein vs. Ensembl Nematostella
BLAST of Homeodomain protein vs. Ensembl Medaka
BLAST of Homeodomain protein vs. Planmine SMEST

BLAST of Homeodomain protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HOXA7	2.028e-32	75.68	homeobox A7 [Source:HGNC Symbol;Acc:HGNC:5108]	[more]
HOXB7	1.697e-31	72.97	homeobox B7 [Source:HGNC Symbol;Acc:HGNC:5118]	[more]
HOXC6	6.010e-30	70.89	homeobox C6 [Source:HGNC Symbol;Acc:HGNC:5128]	[more]
HOXC6	8.470e-30	70.89	homeobox C6 [Source:HGNC Symbol;Acc:HGNC:5128]	[more]
HOXB6	9.971e-30	67.90	homeobox B6 [Source:HGNC Symbol;Acc:HGNC:5117]	[more]

BLAST of Homeodomain protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mab-5	7.546e-26	61.84	Homeobox protein mab-5 [Source:UniProtKB/Swiss-Pr...	[more]
lin-39	4.232e-24	60.49	Homeobox protein lin-39 [Source:UniProtKB/Swiss-P...	[more]
lin-39	4.232e-24	60.49	Homeobox protein lin-39 [Source:UniProtKB/Swiss-P...	[more]
php-3	1.818e-17	56.45	Posterior Hox gene Paralog [Source:UniProtKB/TrEM...	[more]
php-3	1.818e-17	56.45	Posterior Hox gene Paralog [Source:UniProtKB/TrEM...	[more]

BLAST of Homeodomain protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ubx	7.655e-37	75.31	gene:FBgn0003944 transcript:FBtr0083348	[more]
abd-A	6.649e-36	62.38	gene:FBgn0000014 transcript:FBtr0306337	[more]
abd-A	6.649e-36	62.38	gene:FBgn0000014 transcript:FBtr0083387	[more]
abd-A	6.649e-36	62.38	gene:FBgn0000014 transcript:FBtr0300485	[more]
abd-A	5.300e-35	62.38	gene:FBgn0000014 transcript:FBtr0083388	[more]

BLAST of Homeodomain protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hoxb7a	7.564e-32	74.32	homeobox B7a [Source:NCBI gene;Acc:58044]	[more]
hoxc6b	1.351e-31	66.67	homeobox C6b [Source:NCBI gene;Acc:58045]	[more]
hoxc6b	1.989e-31	65.93	homeobox C6b [Source:NCBI gene;Acc:58045]	[more]
hoxc6b	2.208e-31	65.93	homeobox C6b [Source:NCBI gene;Acc:58045]	[more]
hoxb6a	2.162e-30	69.14	homeobox B6a [Source:NCBI gene;Acc:30341]	[more]

BLAST of Homeodomain protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cd276	6.805e-33	72.73	CD276 molecule [Source:Xenbase;Acc:XB-GENE-921537]	[more]
HOXB7	4.892e-32	74.32	homeobox B7 [Source:NCBI gene;Acc:100494663]	[more]
HOXB6	2.348e-31	69.05	homeobox B6 [Source:NCBI gene;Acc:100124320]	[more]
zdhhc15	1.057e-30	69.51	zinc finger DHHC-type containing 15 [Source:Xenbas...	[more]
aldh7a1	3.884e-29	70.51	aldehyde dehydrogenase 7 family member A1 [Source:...	[more]

BLAST of Homeodomain protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hoxa7	3.946e-33	73.68	homeobox A7 [Source:MGI Symbol;Acc:MGI:96179]	[more]
Hoxb7	7.525e-33	74.32	homeobox B7 [Source:MGI Symbol;Acc:MGI:96188]	[more]
Hoxb6	5.129e-30	67.90	homeobox B6 [Source:MGI Symbol;Acc:MGI:96187]	[more]
Hoxb6	5.129e-30	67.90	homeobox B6 [Source:MGI Symbol;Acc:MGI:96187]	[more]
Hoxc6	5.815e-30	70.89	homeobox C6 [Source:MGI Symbol;Acc:MGI:96197]	[more]

BLAST of Homeodomain protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q01622\|HLOX2_HELRO	3.119e-37	72.04	Homeobox protein LOX2 (Fragment) OS=Helobdella rob...	[more]
sp\|Q8T940\|UBX_JUNCO	3.363e-36	73.49	Homeotic protein ultrabithorax OS=Junonia coenia O...	[more]
sp\|P15856\|ABDA_APIME	7.677e-35	78.08	Homeobox protein abdominal-A homolog (Fragment) OS...	[more]
sp\|Q07961\|ABDA_TRICA	1.431e-34	68.13	Homeobox protein abdominal-A homolog OS=Tribolium ...	[more]
sp\|O76762\|ABDA_ANOGA	1.775e-34	73.75	Homeobox protein abdominal-A homolog OS=Anopheles ...	[more]

BLAST of Homeodomain protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
P91714	1.524e-137	59.30	Homeodomain protein OS=Girardia tigrina OX=6162 GN...	[more]
Q26081	1.860e-49	90.32	Homeodomain protein (Fragment) OS=Polycelis nigra ...	[more]
A0A068Y797	2.018e-49	81.63	Homeodomain protein OS=Echinococcus multilocularis...	[more]
A0A068WDW5	2.741e-49	81.63	Homeodomain protein OS=Echinococcus granulosus OX=...	[more]
A0A158QEJ7	1.752e-47	80.41	Homeobox domain-containing protein OS=Hymenolepis ...	[more]

BLAST of Homeodomain protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hoxb7a	3.580e-32	75.68	homeobox B7 [Source:NCBI gene;Acc:103045369]	[more]
hoxb6a	3.374e-30	69.14	homeobox protein Hox-B6a [Source:NCBI gene;Acc:103...	[more]
hoxc6a	6.367e-30	69.51	homeobox C6 [Source:NCBI gene;Acc:103034651]	[more]
hoxb6b	3.118e-29	70.13	homeobox protein Hox-B6b [Source:NCBI gene;Acc:103...	[more]
hoxb5a	5.399e-29	65.88	homeobox protein Hox-B5a [Source:NCBI gene;Acc:111...	[more]

BLAST of Homeodomain protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000005057.1	1.712e-29	72.60	pep scaffold:Pmarinus_7.0:GL483321:9136:13526:-1 g...	[more]
hoxb7a	4.613e-29	86.21	homeobox B7a [Source:NCBI gene;Acc:58044]	[more]
ENSPMAT00000011116.1	6.698e-29	81.36	pep scaffold:Pmarinus_7.0:GL482944:7995:8174:-1 ge...	[more]
hoxd4a	1.510e-25	79.31	homeobox D4a [Source:NCBI gene;Acc:30329]	[more]
ENSPMAT00000011242.1	3.512e-21	69.49	pep scaffold:Pmarinus_7.0:GL476758:607601:607780:-...	[more]

BLAST of Homeodomain protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
YOX1	1.154e-6	29.87	Homeobox transcriptional repressor; binds to Mcm1p...	[more]

BLAST of Homeodomain protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
ANTHOX7	8.405e-19	49.40	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
MOXB	1.321e-17	57.81	MoxB; Predicted protein [Source:UniProtKB/TrEMBL;...	[more]
EDO45896	1.371e-17	64.91	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49445	1.517e-17	53.23	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
ANTHOX1A.NV	2.734e-17	64.41	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Homeodomain protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hoxb6b	5.565e-31	71.79	homeobox protein Hox-B6b [Source:NCBI gene;Acc:101...	[more]
HOXA7	6.506e-30	67.53	homeobox A7 [Source:NCBI gene;Acc:110015904]	[more]
ENSORLT00000021318.2	1.504e-29	72.73	homeobox protein Hox-B6a [Source:NCBI gene;Acc:101...	[more]
hoxc6a	2.188e-29	52.94	homeobox C6 [Source:NCBI gene;Acc:101173938]	[more]
hoxa5a	1.976e-28	51.30	homeobox A5a [Source:NCBI gene;Acc:58055]	[more]

BLAST of Homeodomain protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000043155.1	0.000e+0	100.00	SMESG000043155.1	[more]
SMESG000022667.1	1.020e-28	70.13	SMESG000022667.1	[more]
SMESG000044469.1	6.598e-27	64.10	SMESG000044469.1	[more]
SMESG000079807.1	1.985e-26	65.06	SMESG000079807.1	[more]
SMESG000079807.1	2.580e-26	65.06	SMESG000079807.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30029233 ID=SMED30029233|Name=Homeodomain protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1174bp
TTCCGATCTCGAAAATTTATTTATTTTATGTGAATTATGATGAGTTCCTG
TTTGCAACAATTTGACGCTAACGCATTCATTATTGACAATGATAATCCAA
TGAAAACTAGAAATTTTATGATTGAAAATTCAATTTGCGATTCAATTCGA
CCTGGTTACTCCGATCTGTTGACAGATTCCAGAACAAATTATCATGATTT
AGCGATGAAAAATGATTTTCTAGCGACAATATCGAATAATTTCACTGTGG
AATCCTTTGATAAATGCAACAAATCACATCTTCCGGAATTATTTACGAGA
GGCATTAGTTCCGGGGTCGATGATTCGTGTAAAATGATGAATCAAAACAC
GTTTTGGTCCAGCAATATGCCTCATTTAATGGCAGCAGCAGCAGTCGGTG
GACATTACCCACCATTTCCAGTTACTTCAGTTATGGCGGGAGTTGACCAG
AAAAACTTACCGCAAATTGACATCGATTTACATTCCGATCCAGTTTTATC
TGATTCACATCAAGGCTGTTTGCCTTTGTCCCATACATTCCCAAGTGCTA
ACAATAACAACACGTCACTGTCATCTTTCAATTCCTTTGCAATTGGTTTA
TATTCGAACTATCCCAATCAAATGCAGAGCATAGATGAACTCGATGATGA
TAAGTTTGACATGGATTGTCCGTTAAGAAACGATCAAAAATACACAGATA
ATGAAAACAATTCCAATTCCCGAAGTGAAGGAGGAGCCCAACAAATTTGG
CCTTGGATGACTGTTGTTGGTCCGAATTCTGTTCAAAAGCGCCGAGGAAG
ACAAACATATAGCAGACATCAAACTCTTGAATTGGAAAAAGAATTTCAAT
TCAATCACTACTTGACCCGTCGACGTCGAATTGAAATTGCTCACAATCTT
TGTTTGTCTGAACGACAAATAAAAATCTGGTTTCAGAATCGACGAATGAA
ACTGAAAAAAGAACGACAGCAAATTCGAGAATTGAACGACGAAATTACAA
GGAAAACGATCTCCAAGAAACATTTATCCTCGAATTACAACTGGGAATCC
GTTTCAGTAAGTAGTGGAGGAGCTGATGATGAATCGTACGGATTGGTAAA
CATGTCAGCACCTGTAAATATTATGGGACAACAATAATCTCAGTAGATAA
TATTTATTTGCAATACTTGCTGCT

protein sequence of SMED30029233-orf-1

>SMED30029233-orf-1 ID=SMED30029233-orf-1|Name=SMED30029233-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=367bp
MMSSCLQQFDANAFIIDNDNPMKTRNFMIENSICDSIRPGYSDLLTDSRT
NYHDLAMKNDFLATISNNFTVESFDKCNKSHLPELFTRGISSGVDDSCKM
MNQNTFWSSNMPHLMAAAAVGGHYPPFPVTSVMAGVDQKNLPQIDIDLHS
DPVLSDSHQGCLPLSHTFPSANNNNTSLSSFNSFAIGLYSNYPNQMQSID
ELDDDKFDMDCPLRNDQKYTDNENNSNSRSEGGAQQIWPWMTVVGPNSVQ
KRRGRQTYSRHQTLELEKEFQFNHYLTRRRRIEIAHNLCLSERQIKIWFQ
NRRMKLKKERQQIRELNDEITRKTISKKHLSSNYNWESVSVSSGGADDES
YGLVNMSAPVNIMGQQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000103	central nervous system
PLANA:0000418	head
PLANA:0000429	neoblast

Vocabulary: **INTERPRO**
Term	Definition
IPR029020	Ammonium/urea_transptr
IPR020479	Homeobox_metazoa
IPR001356	Homeobox_dom
IPR009057	Homeobox-like_sf
IPR017970	Homeobox_CS
IPR003119	SAP_A

Vocabulary: **molecular function**
Term	Definition
GO:0003677	DNA binding
GO:0043565	sequence-specific DNA binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 299..326
None	No IPR available	GENE3D	G3DSA:1.10.10.60		coord: 232..312 e-value: 5.3E-31 score: 108.4
None	No IPR available	PANTHER	PTHR45659	FAMILY NOT NAMED	coord: 170..322
None	No IPR available	PANTHER	PTHR45659:SF4	HOMEOTIC PROTEIN ULTRABITHORAX	coord: 170..322
IPR020479	Homeobox domain, metazoa	PRINTS	PR00024	HOMEOBOX	coord: 288..298 score: 63.02 coord: 273..284 score: 49.67 coord: 298..307 score: 80.72
IPR001356	Homeobox domain	SMART	SM00389	HOX_1	coord: 251..313 e-value: 2.0E-23 score: 93.8
IPR001356	Homeobox domain	PFAM	PF00046	Homeodomain	coord: 252..308 e-value: 3.1E-20 score: 71.8
IPR001356	Homeobox domain	PROSITE	PS50071	HOMEOBOX_2	coord: 249..309 score: 21.087
IPR001356	Homeobox domain	CDD	cd00086	homeodomain	coord: 252..310 e-value: 6.5297E-24 score: 91.1508
IPR017970	Homeobox, conserved site	PROSITE	PS00027	HOMEOBOX_1	coord: 284..307
IPR009057	Homeobox-like domain superfamily	SUPERFAMILY	SSF46689	Homeodomain-like	coord: 236..309