glycogen synthase kinase 3

Overview
Nameglycogen synthase kinase 3 (ABD72512.1)
Smed IDSMED30029226
Length (bp)1299
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of glycogen synthase kinase 3 (SMED30029226) t-SNE clustered cells

Violin plots show distribution of expression levels for glycogen synthase kinase 3 (SMED30029226) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of glycogen synthase kinase 3 (SMED30029226) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for glycogen synthase kinase 3 (SMED30029226) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30029226

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30029226h1SMcG0020644 SmedASXL_001282SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30029226h1SMcG0020644 SmedASXL_001282SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
cephalic gangliaSMED30029226h1SMcG0020644 ABD72512smed_ncbi_20240424PMID:18202849
Adell et al., 2008
whole organism asexual adult colorimetric in situ hybridization evidence
ventral nerve cordSMED30029226h1SMcG0020644 ABD72512smed_ncbi_20240424PMID:18202849
Adell et al., 2008
whole organism asexual adult colorimetric in situ hybridization evidence
central nervous systemSMED30029226h1SMcG0020644 ABD72512smed_ncbi_20240424PMID:18202849
Adell et al., 2008
whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30029226h1SMcG0020644 ABD72512smed_ncbi_20240424PMID:18202849
Adell et al., 2008
whole organism asexual adult colorimetric in situ hybridization evidence
epidermisSMED30029226h1SMcG0020644 dd_Smed_v4_4879_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Match: GSK3A (glycogen synthase kinase 3 alpha [Source:HGNC Symbol;Acc:HGNC:4616])

HSP 1 Score: 265.003 bits (676), Expect = 3.541e-84
Identity = 145/364 (39.84%), Postives = 208/364 (57.14%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSVLDSI 1150
            T +V        +S  +     +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV+E  PE++  +   +    + + +L+VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L +S+L Y P  R  P     H  FDELR       N R +P LF+F   ELS+  S+
Sbjct:   19 TTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSL 354          
BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Match: GSK3B (glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617])

HSP 1 Score: 265.003 bits (676), Expect = 4.857e-84
Identity = 143/337 (42.43%), Postives = 201/337 (59.64%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   Y      L +++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N RD P+LF+F  +ELS
Sbjct:   60 KVIGNGSFGVVYQAKL----CDSGE---------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELS 368          
BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Match: GSK3A (glycogen synthase kinase 3 alpha [Source:HGNC Symbol;Acc:HGNC:4616])

HSP 1 Score: 265.774 bits (678), Expect = 1.873e-83
Identity = 145/364 (39.84%), Postives = 208/364 (57.14%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSVLDSI 1150
            T +V        +S  +     +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV+E  PE++  +   +    + + +L+VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L +S+L Y P  R  P     H  FDELR       N R +P LF+F   ELS+  S+
Sbjct:  101 TTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSL 436          
BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Match: GSK3A (glycogen synthase kinase 3 alpha [Source:HGNC Symbol;Acc:HGNC:4616])

HSP 1 Score: 265.774 bits (678), Expect = 1.873e-83
Identity = 145/364 (39.84%), Postives = 208/364 (57.14%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSVLDSI 1150
            T +V        +S  +     +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV+E  PE++  +   +    + + +L+VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L +S+L Y P  R  P     H  FDELR       N R +P LF+F   ELS+  S+
Sbjct:  101 TTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLPPLFNFSAGELSIQPSL 436          
BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Match: GSK3B (glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:HGNC:4617])

HSP 1 Score: 264.233 bits (674), Expect = 4.559e-83
Identity = 143/337 (42.43%), Postives = 201/337 (59.64%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   Y      L +++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N RD P+LF+F  +ELS
Sbjct:   60 KVIGNGSFGVVYQAKL----CDSGE---------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELS 368          
BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Match: gsk-3 (Glycogen synthase kinase-3 [Source:UniProtKB/Swiss-Prot;Acc:Q9U2Q9])

HSP 1 Score: 254.218 bits (648), Expect = 5.496e-81
Identity = 136/325 (41.85%), Postives = 195/325 (60.00%), Query Frame = 2
Query:  113 NQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRN 1087
            +Q V ++    +VIG G+FG +  A + TT      NE         AIKKV QD R+KNREL I++++ +HPNIV  KY+FYS    +               ++YL+L++E  PE++  +   Y      + M++VK+Y YQ+LR+L Y+HS  ICHRDIK  NLL++  S  LKLCDFGSAK L+    +VSYI SRYYRAPEL+FGA +YT +IDVWSAG V+ E+L    +F G   VDQLV++I+VLG+P+ + + +MNP+      P +   P    F  ++  + ++L++ ++ Y P  R  P     H  FDELRN
Sbjct:   29 DQQVEISYYDQKVIGNGSFGVVFLAKLSTT------NEMV-------AIKKVLQDKRFKNRELQIMRKL-NHPNIVKLKYFFYSSGEKK--------------DELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIGICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTNSIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQIKAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFFDELRN 325          
BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Match: C44H4.6 (pep chromosome:WBcel235:X:14596476:14599158:-1 gene:WBGene00008095.1 transcript:C44H4.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C44H4.6)

HSP 1 Score: 202.986 bits (515), Expect = 3.875e-61
Identity = 125/346 (36.13%), Postives = 179/346 (51.73%), Query Frame = 2
Query:  113 NQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLR-------DIPSLFSFLPEE 1129
            ++ V +     Q+IG G+FG + KA +R      ND   A        IKK+  D R+K+REL I+  +  HPNI+   YY+     N                   L+ VME  P+ L+ +  ++ HN   +    +K+Y +Q+LR +G+LH  NI HRDIK  NLLV+ES+  LK+CDFGSAK L     +++YI SRYYRAPEL+FG+++Y T+ID WS G V+GE+L    +F    AVD L   I+  G+PS +D+   N     +    +    I+ F         LELL S++  +P  R  P   L    FD+LR+          IP LF +L  E
Sbjct:   30 DREVEIQFTNLQLIGTGSFGAVYKAVLR-----ENDEPIA--------IKKIKVDDRFKSRELTIMHEM-DHPNIIRLLYYYVMQQENC------------------LNFVMEFMPKDLAYVHRQFAHNDKQMPAYSIKLYMFQLLRGIGFLHLHNIVHRDIKPKNLLVDESNGILKICDFGSAKRLEKNEPNITYICSRYYRAPELIFGSKNYDTSIDTWSVGTVVGELLHNSPIFLADSAVDILALQIKAFGTPSKEDMAKWNYEYVHIPYDTITGVGIQKFIGRKLSLSTLELLNSLMKMDPKLRIKPYEALTLPYFDDLRDPHYKLPSGAPIPPLFDWLERE 343          
BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Match: mpk-1 (Mitogen-activated protein kinase mpk-1 [Source:UniProtKB/Swiss-Prot;Acc:P39745])

HSP 1 Score: 141.739 bits (356), Expect = 7.186e-38
Identity = 87/236 (36.86%), Postives = 129/236 (54.66%), Query Frame = 2
Query:  509 LSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVS----YISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADD---VIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM*WSTS 1195
            LS  HV  + YQ+LR L Y+HS N+ HRD+K SNLL+N ++  LK+CDFG A+     T        Y+++R+YRAPE++  ++ YT +IDVWS GC+L EML    LF G   +DQL  ++ V+GSPS  D   +I        +SLPH    P    +P  + P  L+LL  ML +NP  R    + L H   ++  +  D P        E+   D + +++L E++  W  +
Sbjct:  124 LSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYP-GADPRALDLLDKMLTFNPHNRIDIEQALAHPYLEQYYDPGDEPVCEEPFTLEME-FDDLPKEKLKELI--WEEA 354          
BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Match: mpk-1 (Mitogen-activated protein kinase mpk-1 [Source:UniProtKB/Swiss-Prot;Acc:P39745])

HSP 1 Score: 141.739 bits (356), Expect = 2.050e-37
Identity = 86/231 (37.23%), Postives = 127/231 (54.98%), Query Frame = 2
Query:  509 LSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVS----YISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADD---VIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM 1180
            LS  HV  + YQ+LR L Y+HS N+ HRD+K SNLL+N ++  LK+CDFG A+     T        Y+++R+YRAPE++  ++ YT +IDVWS GC+L EML    LF G   +DQL  ++ V+GSPS  D   +I        +SLPH    P    +P  + P  L+LL  ML +NP  R    + L H   ++  +  D P        E+   D + +++L E++ 
Sbjct:  192 LSNDHVCYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARVTDPQTDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSNADLQCIINDKARSYLISLPHKPKQPWARLYP-GADPRALDLLDKMLTFNPHNRIDIEQALAHPYLEQYYDPGDEPVCEEPFTLEME-FDDLPKEKLKELIW 419          
BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Match: Y106G6D.4 (pep chromosome:WBcel235:I:10114759:10116583:1 gene:WBGene00013701.1 transcript:Y106G6D.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y106G6D.4)

HSP 1 Score: 138.658 bits (348), Expect = 2.742e-36
Identity = 97/334 (29.04%), Postives = 158/334 (47.31%), Query Frame = 2
Query:   95 GFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQ--RIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECF-----PESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFD 1075
             +++ + Q V + +   ++  +G F  + +  + +  ++              AIKK      Y+N EL  +   R K H NIV   + F               +     G    H   E +     P +L +++ +       L+ + +K+YT+Q+   + YL +  I HRDIK  N+LV+    TLK+ DFGSAK ++ G++S SY  +R+YR PELL  A+ Y   +DVWSAGC +GEM++   LF G+     L  +++ +G PSA D+  M  S        V    +K      +Q +  + L ++L Y P +R H  +LL H  FD
Sbjct:   14 AYELPSQQRVGMQMANLRLHARGVFSNVYRGTILSPGTEQEI-----------AIKKTWPKTPYRNFELLFLSGLRRKPHKNIVQMLFAF-------------SRNTTSGEGLEMKHSFCESYVFGFMPYTLQNILKKTR-----LAEVDMKLYTWQLFEGIRYLQAHMIVHRDIKPVNILVDVDKGTLKIADFGSAKVVLRGSSSTSYQVTRFYRPPELLLDAKEYYWMVDVWSAGCCVGEMMKGKVLFPGASIKIMLKLIVQAIGLPSARDLDYMKVSSMIDQQSAVKVIGLKEVLGTENQ-EWADFLGAILRYRPRERLHGPKLLSHPFFD 317          
BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: gskt (gene:FBgn0046332 transcript:FBtr0085784)

HSP 1 Score: 256.529 bits (654), Expect = 5.074e-80
Identity = 145/375 (38.67%), Postives = 217/375 (57.87%), Query Frame = 2
Query:   44 MSSKFLNSHLPN--TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR--------NLRDIPSLFSFLPEELSV 1138
            M+S+  NS L N  T +V       +    ++    +V+G G+FG + +A +  +      NE         AIKKV QD R+KNREL I+++++ H NI+  K++F+S     +              ++YL+LVME  PE+L  +  +Y      L +  V++Y YQ+LR++GYLHS   CHRDIK  N+L++  +  LKLCDFGSAK+LI+G  +VSYI SRYYRAPEL+FG+  YTT ID+WSAGCV+ E+L    +F G   VDQ+V++++V+G+P+++ +  MNP      LP + P P    F   +  + ++L++ MLIY+P  R  P     H  FDELR        N R +P LF+F   E ++
Sbjct:    1 MASQSKNSGLTNKVTTVVATNAFGADVMSEISYTDAKVVGNGSFGVVFQAKMVPS------NEMV-------AIKKVLQDRRFKNRELQIMRKLR-HDNIITLKWFFFSSGEKRD--------------EVYLNLVMEFLPETLYKVERQYARAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGEPNVSYICSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDMNPHYKQFKLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSPLMGCAHPFFDELRQDPHQQLPNGRSLPPLFNFTDYEKTI 347          
BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070475)

HSP 1 Score: 253.062 bits (645), Expect = 1.015e-78
Identity = 143/365 (39.18%), Postives = 209/365 (57.26%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR--------NLRDIPSLFSFLPEELSVLDSI 1150
            T +V      T++   ++    +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I+++++ H NIV   Y+FYS     +              +++L+LV+E  PE++  +  +Y      + +  +++Y YQ+ R+L Y+HS  ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA +YTT IDVWSAGCVL E+L    +F G   VDQLV+VI+VLG+P+ + +  MNP+      P +   P +  F   +  + + L++ +L Y P  R  P +   H  FDELR        N RD+P LF+F   ELS+  S+
Sbjct:   18 TTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGE-------------LVAIKKVLQDRRFKNRELQIMRKLE-HCNIVKLLYFFYSSGEKRD--------------EVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL 354          
BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070469)

HSP 1 Score: 253.447 bits (646), Expect = 1.130e-78
Identity = 143/365 (39.18%), Postives = 209/365 (57.26%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR--------NLRDIPSLFSFLPEELSVLDSI 1150
            T +V      T++   ++    +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I+++++ H NIV   Y+FYS     +              +++L+LV+E  PE++  +  +Y      + +  +++Y YQ+ R+L Y+HS  ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA +YTT IDVWSAGCVL E+L    +F G   VDQLV+VI+VLG+P+ + +  MNP+      P +   P +  F   +  + + L++ +L Y P  R  P +   H  FDELR        N RD+P LF+F   ELS+  S+
Sbjct:   36 TTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGE-------------LVAIKKVLQDRRFKNRELQIMRKLE-HCNIVKLLYFFYSSGEKRD--------------EVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL 372          
BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070472)

HSP 1 Score: 253.447 bits (646), Expect = 1.130e-78
Identity = 143/365 (39.18%), Postives = 209/365 (57.26%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR--------NLRDIPSLFSFLPEELSVLDSI 1150
            T +V      T++   ++    +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I+++++ H NIV   Y+FYS     +              +++L+LV+E  PE++  +  +Y      + +  +++Y YQ+ R+L Y+HS  ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA +YTT IDVWSAGCVL E+L    +F G   VDQLV+VI+VLG+P+ + +  MNP+      P +   P +  F   +  + + L++ +L Y P  R  P +   H  FDELR        N RD+P LF+F   ELS+  S+
Sbjct:   36 TTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGE-------------LVAIKKVLQDRRFKNRELQIMRKLE-HCNIVKLLYFFYSSGEKRD--------------EVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL 372          
BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Match: sgg (gene:FBgn0003371 transcript:FBtr0070473)

HSP 1 Score: 253.447 bits (646), Expect = 1.130e-78
Identity = 143/365 (39.18%), Postives = 209/365 (57.26%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR--------NLRDIPSLFSFLPEELSVLDSI 1150
            T +V      T++   ++    +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I+++++ H NIV   Y+FYS     +              +++L+LV+E  PE++  +  +Y      + +  +++Y YQ+ R+L Y+HS  ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA +YTT IDVWSAGCVL E+L    +F G   VDQLV+VI+VLG+P+ + +  MNP+      P +   P +  F   +  + + L++ +L Y P  R  P +   H  FDELR        N RD+P LF+F   ELS+  S+
Sbjct:   36 TTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGE-------------LVAIKKVLQDRRFKNRELQIMRKLE-HCNIVKLLYFFYSSGEKRD--------------EVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSL 372          
BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: gsk3ba (glycogen synthase kinase 3 beta, genome duplicate a [Source:ZFIN;Acc:ZDB-GENE-990714-4])

HSP 1 Score: 265.003 bits (676), Expect = 3.579e-84
Identity = 144/337 (42.73%), Postives = 202/337 (59.94%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS  + +               ++YL+LV++  PE++  +   Y      L M++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ PSLF+F  +ELS
Sbjct:   60 KVIGNGSFGVVYQAKL----CDSGE---------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGDKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELREPNVKLPNGREKPSLFNFTTQELS 368          
BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: gsk3ab (glycogen synthase kinase 3 alpha b [Source:ZFIN;Acc:ZDB-GENE-990714-3])

HSP 1 Score: 261.536 bits (667), Expect = 1.622e-82
Identity = 139/338 (41.12%), Postives = 203/338 (60.06%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSV 1138
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   ++ +   + +++VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT+ ID+WSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P+ R  P     H  FDELR       N R++P LF+F P ELS+
Sbjct:   87 KVIGNGSFGVVYQARL----IDSQE---------MVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDFVPETVYRVARHFNKSKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAISLCSRLLEYTPVTRLSPLEACAHAFFDELRQPNARLPNGRELPQLFNFSPVELSI 396          
BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: gsk3bb (glycogen synthase kinase 3 beta, genome duplicate b [Source:ZFIN;Acc:ZDB-GENE-090312-2])

HSP 1 Score: 260.381 bits (664), Expect = 1.897e-82
Identity = 141/337 (41.84%), Postives = 199/337 (59.05%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS  + +               ++YL+LVM+  PE++  +   Y      L M++VK+Y YQ+ R+L Y+HS+ ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++ID+WSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ P LF+F  +ELS
Sbjct:   60 KVIGNGSFGVVYQAKLCDTGE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGDKK--------------DEVYLNLVMDYVPENVYRVARHYSKAKQNLPMVYVKLYMYQLFRSLAYIHSYGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHTFFDELREPNLKLPNGRERPVLFNFTTQELS 368          
BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: gsk3aa (glycogen synthase kinase 3 alpha a [Source:ZFIN;Acc:ZDB-GENE-060503-796])

HSP 1 Score: 254.218 bits (648), Expect = 1.629e-79
Identity = 136/338 (40.24%), Postives = 199/338 (58.88%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNL-------RDIPSLFSFLPEELSV 1138
            +VIG G+FG + +A +  T             ++V AIKKV QD R+KNREL I++++  H NIV  +Y+FY     ++              ++YL+LV++  PE++  +   +     I+ + +VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT+ ID+WSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P+ R  P +   H  FDELR         R++P LF+F   EL +
Sbjct:  114 KVIGNGSFGVVYQARLIDTH------------EWV-AIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYCSGEKKD--------------EVYLNLVLDYVPETVYRVARHFSKAKTIIPIFYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLQACAHAFFDELRQPGTRLPSGRELPPLFNFTTTELMI 423          
BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Match: mapk3 (mitogen-activated protein kinase 3 [Source:ZFIN;Acc:ZDB-GENE-040121-1])

HSP 1 Score: 148.288 bits (373), Expect = 5.540e-40
Identity = 90/236 (38.14%), Postives = 133/236 (56.36%), Query Frame = 2
Query:  509 LSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTS------VSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADD---VIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIP---SLFSFLPEELSVLDSIEQKRLIEMVM 1180
            LS  H+  + YQ+LR L Y+HS N+ HRD+K SNLL+N ++  LK+CDFG A+  IA            Y+++R+YRAPE++  ++ YT +ID+WS GC+L EML    +F G   +DQL  ++ VLGSPS DD   +I M       SLP     P    FP  +    L+LL  ML +NP+KR +  + L H   ++  +  D P     F+F  E    LD + +++L E++ 
Sbjct:  152 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLIN-TTCDLKICDFGLAR--IADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINMKARNYLQSLPQKPKIPWNKLFP-KADNKALDLLDRMLTFNPLKRINVEQALAHPYLEQYYDPSDEPVAEEPFTFNME----LDDLPKEKLKELIF 379          
BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 264.233 bits (674), Expect = 5.369e-84
Identity = 142/337 (42.14%), Postives = 199/337 (59.05%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   Y      L M++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ P+LF+F  +ELS
Sbjct:   39 KVIGNGSFGVVYQAKLCDTGE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELS 347          
BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 264.618 bits (675), Expect = 8.573e-84
Identity = 142/337 (42.14%), Postives = 199/337 (59.05%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   Y      L M++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ P+LF+F  +ELS
Sbjct:   66 KVIGNGSFGVVYQAKLCDTGE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELS 374          
BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 263.848 bits (673), Expect = 2.117e-83
Identity = 142/337 (42.14%), Postives = 200/337 (59.35%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    ++              ++YL+LV++  PE++  +   Y      L M++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ P+LF+F  +ELS
Sbjct:   39 KVIGNGSFGVVYQAKLCDTGE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKKD--------------EVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELS 347          
BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 259.61 bits (662), Expect = 2.192e-82
Identity = 139/331 (41.99%), Postives = 195/331 (58.91%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSF 1117
            +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   Y      L M++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ P+LF+F
Sbjct:   60 KVIGNGSFGVVYQAKLCDTGE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNF 362          
BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Match: GSK3B (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:100489648])

HSP 1 Score: 257.684 bits (657), Expect = 4.101e-81
Identity = 142/346 (41.04%), Postives = 199/346 (57.51%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIK---------LFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   Y      L M++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P             F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ P+LF+F  +ELS
Sbjct:   60 KVIGNGSFGVVYQAKLCDTGE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVSSGYVFLQVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELRDPNLKLPNGREFPALFNFTTQELS 377          
BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Gsk3a (glycogen synthase kinase 3 alpha [Source:MGI Symbol;Acc:MGI:2152453])

HSP 1 Score: 267.7 bits (683), Expect = 2.801e-84
Identity = 146/365 (40.00%), Postives = 211/365 (57.81%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCP-IKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNL-------RDIPSLFSFLPEELSVLDSI 1150
            T +V        +S  +     +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV+E  PE++  +   +    +I  ++++K+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P  K+F    + P+ + L +S+L Y P  R  P     H  FDELR L       R +P LF+F P ELS+  S+
Sbjct:  101 TTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSL 437          
BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Gsk3b (glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437])

HSP 1 Score: 265.003 bits (676), Expect = 3.960e-84
Identity = 143/337 (42.43%), Postives = 201/337 (59.64%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   Y      L +++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N RD P+LF+F  +ELS
Sbjct:   60 KVIGNGSFGVVYQAKL----CDSGE---------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELS 368          
BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Gsk3a (glycogen synthase kinase 3 alpha [Source:MGI Symbol;Acc:MGI:2152453])

HSP 1 Score: 266.929 bits (681), Expect = 4.072e-84
Identity = 146/365 (40.00%), Postives = 211/365 (57.81%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCP-IKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNL-------RDIPSLFSFLPEELSVLDSI 1150
            T +V        +S  +     +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV+E  PE++  +   +    +I  ++++K+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P  K+F    + P+ + L +S+L Y P  R  P     H  FDELR L       R +P LF+F P ELS+  S+
Sbjct:  101 TTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSL 437          
BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Gsk3b (glycogen synthase kinase 3 beta [Source:MGI Symbol;Acc:MGI:1861437])

HSP 1 Score: 258.84 bits (660), Expect = 1.606e-81
Identity = 144/351 (41.03%), Postives = 205/351 (58.40%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCP--------------IKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   Y      L +++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P              +++F P  + P+ + L + +L Y P  R  P     H  FDELR       N RD P+LF+F  +ELS
Sbjct:   60 KVIGNGSFGVVYQAKL----CDSGE---------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKDSPGAGHFTPGVRVFRPR-TPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELS 381          
BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Match: Mapk1 (mitogen-activated protein kinase 1 [Source:MGI Symbol;Acc:MGI:1346858])

HSP 1 Score: 147.132 bits (370), Expect = 9.196e-40
Identity = 88/236 (37.29%), Postives = 134/236 (56.78%), Query Frame = 2
Query:  509 LSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTS------VSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADD---VIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIP---SLFSFLPEELSVLDSIEQKRLIEMVM 1180
            LS  H+  + YQ+LR L Y+HS N+ HRD+K SNLL+N ++  LK+CDFG A+  +A            Y+++R+YRAPE++  ++ YT +ID+WS GC+L EML    +F G   +DQL  ++ +LGSPS +D   +I +      +SLPH    P    FP N+    L+LL  ML +NP KR    + L H   ++  +  D P   + F F  E    LD + +++L E++ 
Sbjct:  119 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLAR--VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP-NADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDME----LDDLPKEKLKELIF 346          
BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|P18265|GSK3A_RAT (Glycogen synthase kinase-3 alpha OS=Rattus norvegicus OX=10116 GN=Gsk3a PE=1 SV=1)

HSP 1 Score: 270.781 bits (691), Expect = 8.620e-85
Identity = 146/364 (40.11%), Postives = 211/364 (57.97%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNL-------RDIPSLFSFLPEELSVLDSI 1150
            T +V        +S  +     +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV+E  PE++  +   +    +I+ +++VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L +S+L Y P  R  P     H  FDELR+L       R +P LF+F P ELS+  S+
Sbjct:  101 TTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DELYLNLVLEYVPETVYRVARHFTKAKLIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRSLGTQLPNNRPLPPLFNFSPGELSIQPSL 436          
BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|Q10452|GSK3_SCHPO (Protein kinase gsk3 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=gsk3 PE=1 SV=3)

HSP 1 Score: 265.774 bits (678), Expect = 6.089e-84
Identity = 150/364 (41.21%), Postives = 207/364 (56.87%), Query Frame = 2
Query:  110 TNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRN--------------LRDIPSLFSFLPEELSVLDSIEQK 1159
            T +   L+  + +V+G G+FG +    V   +SDS             AIK+V QD R+KNREL I+ RI  HPNIVD   Y+Y+  +N                ++YL+LV+E  PE++      Y    + + ML VK+Y YQ+LR+L Y+H+  ICHRDIK  NLL++  +  LKLCDFGSAK L+AG  +VSYI SRYYRAPEL+FGA  YT AID+WS GCV+ E++    LF G   +DQLV++I++LG+PS + +  MNP+      P + P P+   F  +   D L+LL+ ML Y P  R      + H  FDELR+               R +P LF+F P ELS+   + QK
Sbjct:   24 TGEVKQLSYTSSKVVGSGSFGVV--MQVHLIESDSK-----------AAIKRVLQDKRFKNRELQIM-RIMKHPNIVDLIAYYYTTGDNS--------------DEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHASGICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYTHAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQIRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHPFFDELRDPNTKLHNSRNPDASPRHLPELFNFSPFELSIRPDLNQK 359          
BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|Q39019|KSG10_ARATH (Shaggy-related protein kinase kappa OS=Arabidopsis thaliana OX=3702 GN=ASK10 PE=2 SV=2)

HSP 1 Score: 266.544 bits (680), Expect = 8.023e-84
Identity = 148/337 (43.92%), Postives = 200/337 (59.35%), Query Frame = 2
Query:  149 VIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLH-SFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            V+G G+FG + +A  R T               V AIKKV QD RYKNREL I+Q +  HPN V  K+ F+S  +NE               ++YL+LV+E  PE+++ +   Y     ++ +++VK+YTYQ+ RAL Y+H SF +CHRDIK  NLLVN  +  LK+CDFGSAK L+ G  +VSYI SRYYRAPEL+FGA  YTTAID+WS GCV+ E+L    LF G   VDQLV++I+VLG+P+ +++  MNP+      P + P P    F     P+ ++LL     Y+P  R       +H  FDELR       N R +P LF+F P+ELS
Sbjct:   88 VVGTGSFGMVFQAKCRETGE-------------VVAIKKVLQDKRYKNRELQIMQML-DHPNAVALKHSFFSRTDNE---------------EVYLNLVLEFVPETVNRVARSYSRTNQLMPLIYVKLYTYQICRALAYIHNSFGLCHRDIKPQNLLVNPHTHQLKICDFGSAKVLVKGEPNVSYICSRYYRAPELIFGASEYTTAIDIWSTGCVMAELLLGQPLFPGESGVDQLVEIIKVLGTPTREEIKCMNPNYTEFKFPQIKPHPWHKVFQKRLPPEAVDLLCRFFQYSPNLRCTALEACIHPLFDELRDPNTRLPNGRPLPPLFNFKPQELS 395          
BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|Q2NL51|GSK3A_MOUSE (Glycogen synthase kinase-3 alpha OS=Mus musculus OX=10090 GN=Gsk3a PE=1 SV=2)

HSP 1 Score: 267.7 bits (683), Expect = 1.960e-83
Identity = 146/365 (40.00%), Postives = 211/365 (57.81%), Query Frame = 2
Query:   80 TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCP-IKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNL-------RDIPSLFSFLPEELSVLDSI 1150
            T +V        +S  +     +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV+E  PE++  +   +    +I  ++++K+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P  K+F    + P+ + L +S+L Y P  R  P     H  FDELR L       R +P LF+F P ELS+  S+
Sbjct:  101 TTVVATVGQGPERSQEVAYTDIKVIGNGSFGVVYQARLAETRE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DELYLNLVLEYVPETVYRVARHFTKAKLITPIIYIKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQLPNDRPLPPLFNFSPGELSIQPSL 437          
BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Match: sp|P49841|GSK3B_HUMAN (Glycogen synthase kinase-3 beta OS=Homo sapiens OX=9606 GN=GSK3B PE=1 SV=2)

HSP 1 Score: 265.003 bits (676), Expect = 2.332e-83
Identity = 143/337 (42.43%), Postives = 201/337 (59.64%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   Y      L +++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N RD P+LF+F  +ELS
Sbjct:   60 KVIGNGSFGVVYQAKL----CDSGE---------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKK--------------DEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELS 368          
BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: Q1WBW1 (Glycogen synthase kinase 3 OS=Schmidtea mediterranea OX=79327 GN=GSK3.3 PE=2 SV=1)

HSP 1 Score: 735.717 bits (1898), Expect = 0.000e+0
Identity = 378/379 (99.74%), Postives = 379/379 (100.00%), Query Frame = 2
Query:   44 MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM 1180
            MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYSMINNENSNSSNQMSKKQSSGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKI+TYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM
Sbjct:    1 MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYSMINNENSNSSNQMSKKQSSGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIHTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM 379          
BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: A4USB2 (Glycogen synthase kinase 3 OS=Girardia tigrina OX=6162 GN=GSK3 PE=2 SV=1)

HSP 1 Score: 557.755 bits (1436), Expect = 0.000e+0
Identity = 280/398 (70.35%), Postives = 306/398 (76.88%), Query Frame = 2
Query:   44 MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESA---------------------KSVKFVGAIKKV-----HQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXX-------------------------XXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR 1084
            MS++FLNSHLPNTQIVNGFQMHTN+SV+L VNTFQVIGQGTFGYIEKANVR  +S   + E+                      +  KFVGAIKKV     HQDPRYKNRELNIIQR+KSHPNIV+F+YY+YSM                                 S   S   SSGDIYLHLVMEC PESLSDLI RYHHNG  LS  H+KIYT+QMLRALGYLHS N+CHRDIKSSNLLV++ SL+LKLCDFGSAKEL AG TSVSYISSRYYRAPELLFGAQ YTTAIDVWSAGCVLGEM+RMGCLFTGSDAVDQLVKVIRVLGSPS +DV AMNPSCPPMSLPHVLPCPIKLFFPH++ PDLL+ L++MLIYNP KR+HPTRL LHRCFDELR
Sbjct:    1 MSTRFLNSHLPNTQIVNGFQMHTNKSVSLTVNTFQVIGQGTFGYIEKANVRARRSGRGEGENGDDETKDTRDGLDAMEVGEAAPEDAKFVGAIKKVAIKKVHQDPRYKNRELNIIQRVKSHPNIVEFRYYYYSMLHGATASNTGSSHHGCNNNANNNNNNTRRQQQQSTGNSGTGSSGDIYLHLVMECVPESLSDLIARYHHNGASLSARHIKIYTFQMLRALGYLHSLNVCHRDIKSSNLLVDQRSLSLKLCDFGSAKELTAGATSVSYISSRYYRAPELLFGAQQYTTAIDVWSAGCVLGEMVRMGCLFTGSDAVDQLVKVIRVLGSPSPEDVAAMNPSCPPMSLPHVLPCPIKLFFPHHACPDLLDALSAMLIYNPAKRAHPTRLFLHRCFDELR 398          
BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: D2DJU1 (Gsk3-like protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 412.535 bits (1059), Expect = 1.642e-141
Identity = 223/223 (100.00%), Postives = 223/223 (100.00%), Query Frame = 2
Query:   44 MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSR 712
            MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYSMINNENSNSSNQMSKKQSSGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSR
Sbjct:    1 MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYSMINNENSNSSNQMSKKQSSGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSR 223          
BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: A0A183SGQ0 (Protein kinase domain-containing protein OS=Schistocephalus solidus OX=70667 GN=SSLN_LOCUS3398 PE=4 SV=1)

HSP 1 Score: 365.54 bits (937), Expect = 3.442e-118
Identity = 196/395 (49.62%), Postives = 250/395 (63.29%), Query Frame = 2
Query:   71 LPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRT----TKSDSNDNESAKSVKFVG--------------AIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXG-------DIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM 1180
            +P   +V       N  V ++++    IGQGTFG IEKA + T     KS  + ++S  S +                 A+K+V QDPRYKNREL+I+Q +  HPNIV F YY++S  +   S  S    +   +        D+YLHLV+ECFP SL +L+  Y      +  L VK++TYQML+AL YLH+  ICHRDIKSSNLLVNESS+ LKLCDFGSAKE++ G+ +VSYISSRYYRAPELLFGAQ YT AID W AGCVL EMLR  CLFTG+D+VDQLVK+IRVLG+PSA+D+ +MNP     + P V  CP+KLFFP ++  DLL L++ ML+YNP  R  P R LL  CFDELR+LR    L +  P    + DS  +  +    M
Sbjct:   65 MPRQLVVQARNALDNTPVPIHLSFTGTIGQGTFGQIEKATLTTPPPPGKSGEHADKSTDSSRVNASGSVSNTETKVLSVAVKRVLQDPRYKNRELSIMQTLNRHPNIVKFYYYYFSTSSGSRSRRSQPTCEGVCTDMPLNTEMDVYLHLVLECFPGSLCELVYVYFQRSQSIPPLTVKLFTYQMLKALAYLHNHQICHRDIKSSNLLVNESSMVLKLCDFGSAKEMVPGSANVSYISSRYYRAPELLFGAQMYTCAIDTWGAGCVLAEMLRHQCLFTGADSVDQLVKIIRVLGTPSAEDIASMNPMYESYNFPDVQSCPVKLFFPRHTPADLLSLMSKMLVYNPTNRLSPKRGLLDPCFDELRDLRASGKLPNGTPLPSHLFDSDPEPPITAAPM 459          
BLAST of glycogen synthase kinase 3 vs. TrEMBL
Match: A0A0X3PHU5 (Protein kinase domain-containing protein (Fragment) OS=Schistocephalus solidus OX=70667 GN=TR145951 PE=4 SV=1)

HSP 1 Score: 365.54 bits (937), Expect = 8.806e-118
Identity = 196/395 (49.62%), Postives = 250/395 (63.29%), Query Frame = 2
Query:   71 LPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRT----TKSDSNDNESAKSVKFVG--------------AIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXG-------DIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM 1180
            +P   +V       N  V ++++    IGQGTFG IEKA + T     KS  + ++S  S +                 A+K+V QDPRYKNREL+I+Q +  HPNIV F YY++S  +   S  S    +   +        D+YLHLV+ECFP SL +L+  Y      +  L VK++TYQML+AL YLH+  ICHRDIKSSNLLVNESS+ LKLCDFGSAKE++ G+ +VSYISSRYYRAPELLFGAQ YT AID W AGCVL EMLR  CLFTG+D+VDQLVK+IRVLG+PSA+D+ +MNP     + P V  CP+KLFFP ++  DLL L++ ML+YNP  R  P R LL  CFDELR+LR    L +  P    + DS  +  +    M
Sbjct:   93 MPRQLVVQARNALDNTPVPIHLSFTGTIGQGTFGQIEKATLTTPPPPGKSGEHADKSTDSSRVNASGSVSNTETKVLSVAVKRVLQDPRYKNRELSIMQTLNRHPNIVKFYYYYFSTSSGSRSRRSQPTCEGVCTDMPLNTEMDVYLHLVLECFPGSLCELVYVYFQRSQSIPPLTVKLFTYQMLKALAYLHNHQICHRDIKSSNLLVNESSMVLKLCDFGSAKEMVPGSANVSYISSRYYRAPELLFGAQMYTCAIDTWGAGCVLAEMLRHQCLFTGADSVDQLVKIIRVLGTPSAEDIASMNPMYESYNFPDVQSCPVKLFFPRHTPADLLSLMSKMLVYNPTNRLSPKRGLLDPCFDELRDLRASGKLPNGTPLPSHLFDSDPEPPITAAPM 487          
BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: gsk3ba (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:103021870])

HSP 1 Score: 265.388 bits (677), Expect = 2.420e-84
Identity = 144/337 (42.73%), Postives = 203/337 (60.24%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS  + ++              ++YL+LV++  PE++  +   Y      L M++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ PSLF+F  +ELS
Sbjct:   60 KVIGNGSFGVVYQAKL----CDSGE---------MVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGDKKD--------------EVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNIKLPNGREKPSLFNFTTQELS 368          
BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: ENSAMXT00000005621.2 (glycogen synthase kinase-3 beta-like [Source:NCBI gene;Acc:103043574])

HSP 1 Score: 264.618 bits (675), Expect = 2.431e-84
Identity = 144/337 (42.73%), Postives = 200/337 (59.35%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS  + +               ++YL+LV++  PE++  +   Y     IL ML+VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ P LF+F  +ELS
Sbjct:   42 KVIGNGSFGVVYQAKLCDTGE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGDKK--------------DEVYLNLVLDYVPETVYRVSRHYSRAKQILPMLYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPKTPPEAIALCSRLLEYTPTARFTPLEACAHAFFDELRVPTLKLPNGRERPPLFNFTTQELS 350          
BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: ENSAMXT00000036323.1 (glycogen synthase kinase-3 beta-like [Source:NCBI gene;Acc:103043574])

HSP 1 Score: 265.003 bits (676), Expect = 2.884e-84
Identity = 144/337 (42.73%), Postives = 200/337 (59.35%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            +VIG G+FG + +A +  T               + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS  + +               ++YL+LV++  PE++  +   Y     IL ML+VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ P LF+F  +ELS
Sbjct:   59 KVIGNGSFGVVYQAKLCDTGE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGDKK--------------DEVYLNLVLDYVPETVYRVSRHYSRAKQILPMLYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPKTPPEAIALCSRLLEYTPTARFTPLEACAHAFFDELRVPTLKLPNGRERPPLFNFTTQELS 367          
BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: gsk3ba (glycogen synthase kinase 3 beta [Source:NCBI gene;Acc:103021870])

HSP 1 Score: 259.61 bits (662), Expect = 1.511e-82
Identity = 141/335 (42.09%), Postives = 201/335 (60.00%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEE 1129
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS  + ++              ++YL+LV++  PE++  +   Y      L M++VK+Y YQ+ R+L Y+HSF ICHRDIK  NLL++  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT++IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       N R+ PSLF+F  ++
Sbjct:   60 KVIGNGSFGVVYQAKL----CDSGE---------MVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGDKKD--------------EVYLNLVLDYVPETVYRVARHYSRAKQTLPMVYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNIKLPNGREKPSLFNFTTQD 366          
BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Match: gsk3aa (glycogen synthase kinase-3 alpha-like [Source:NCBI gene;Acc:103032471])

HSP 1 Score: 260.381 bits (664), Expect = 2.114e-82
Identity = 138/338 (40.83%), Postives = 202/338 (59.76%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNL-------RDIPSLFSFLPEELSV 1138
            +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    ++              ++YL+LV++  PE++  +   ++    I+ +++VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+LI G  +VSYI SRYYRAPEL+FGA  YT+ ID+WSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P+ R  P +   H  FDELR         R++P LF+F   ELS+
Sbjct:   81 KVIGNGSFGVVYQARLIDTQE-------------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKKD--------------EVYLNLVLDFVPETVYRVARHFNKAKTIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAVLKLCDFGSAKQLIRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLQACAHAFFDELRQPGTRLPSGRELPQLFNFTTTELSI 390          
BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: mapk1 (mitogen-activated protein kinase 1 [Source:ZFIN;Acc:ZDB-GENE-030722-2])

HSP 1 Score: 144.05 bits (362), Expect = 2.085e-39
Identity = 90/239 (37.66%), Postives = 130/239 (54.39%), Query Frame = 2
Query:  497 NGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTS------VSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADD---VIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIP---SLFSFLPEELSVLDSIEQKRLIEMV 1177
             G  LS  H+  + YQ+LR L Y+HS N+ HRD+K SNLL+N ++  LK+CDFG A+  +A            Y+++R+YRAPE++  ++ YT +ID+WS GC+L EML    LF G   +DQL  ++ +LGSPS +D   +I M       SLP     P    FP  +    L+LL  ML +NP +R      L H   ++  +  D P     F F  E    LD + ++RL EM+
Sbjct:  128 KGQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLAR--VADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPLFPGKHYLDQLNHILGILGSPSQEDLDCIINMKARNYLQSLPPKAKVPWNRLFP-KADSKALDLLDKMLTFNPHRRITVEEALAHPYLEQYYDPSDEPVAEEPFRFDME----LDDLPKERLKEMI 358          
BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 135.576 bits (340), Expect = 7.652e-37
Identity = 101/341 (29.62%), Postives = 158/341 (46.33%), Query Frame = 2
Query:  131 NVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKEL-IAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCP-IKLFFPHNSQPDLL-----------ELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFS 1114
            N    + IG+GT+G + KA  + T         A ++K +    +    P    RE+++++ + +HPNIV      +                     +  L+LV E   + L   +     +G+ L +  VK Y YQ+L+ + + HS  I HRD+K  NLL+N     +KL DFG A+   +   T    + + +YRAPE+L G +HY+T++DVWS GC+  EML    LF G   +DQL ++ R LG+P  D+V+           P V   P  K  FP  +  +L            +LL  ML Y+P +R      L H  F  ++ +  +P L S
Sbjct:    3 NFQKVEKIGEGTYGVVYKARNKLTG-------EAVALKKIRLDTETEGVPSTAIREISLLREL-NHPNIVRLLTIIH--------------------SEKKLYLVFELLDQDLKKFMDNATPSGIPLPL--VKSYLYQLLQGIAFCHSHRILHRDLKPQNLLINAEG-AIKLADFGLARAFGVPQRTYTHEVVTLWYRAPEILLGCKHYSTSVDVWSIGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTP--DEVV----------WPGVSQLPDYKSTFPRWANQELTKVVPTLNFEGRDLLALMLQYDPNQRVTANMALSHCFFQNVKQI--VPQLRS 298          
BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: mapk15 (mitogen-activated protein kinase 15 [Source:ZFIN;Acc:ZDB-GENE-050522-307])

HSP 1 Score: 137.117 bits (344), Expect = 9.063e-36
Identity = 87/273 (31.87%), Postives = 138/273 (50.55%), Query Frame = 2
Query:  293 RELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIA-----GTTSVS-YISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNP----------SCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLH 1063
            RE+  +Q    HPNI++ +    +  +                 DIYL  V +     L  +I      G IL  +H    TYQ+L+A  Y+HS N+ HRD K SN+L++     +KLCDFG A+ L       G  +++ Y+++R+YRAPE+L  +  YT  +D+WS GC++GEML    +F G+  ++Q+ +++ V+  PS +DV+A+                 SL  +LP         N+ P+ L+LL  +L++NP KR      L H
Sbjct:   60 REIIFLQEFGDHPNIINLRNVLRADNDK----------------DIYL--VFDFMDTDLHAVI----RKGNILKDVHKAYITYQLLKATKYIHSGNVIHRDQKPSNVLLDGECF-VKLCDFGLARSLKQIRDEPGDPALTEYVATRWYRAPEILLASPRYTKGVDMWSVGCIVGEMLLGKAIFPGTSTLNQIERIMSVIPQPSKEDVLAIKSEYGGSVLEKMGRQRQSLESLLP---------NAPPNALDLLKRLLVFNPEKRLTAEEALGH 300          
BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: mapk15 (mitogen-activated protein kinase 15 [Source:ZFIN;Acc:ZDB-GENE-050522-307])

HSP 1 Score: 136.346 bits (342), Expect = 2.043e-35
Identity = 87/273 (31.87%), Postives = 139/273 (50.92%), Query Frame = 2
Query:  293 RELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIA-----GTTSVS-YISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNP----------SCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLH 1063
            RE+  +Q    HPNI++ +    +  +                 DIYL  V +     L  +I +    G IL  +H    TYQ+L+A  Y+HS N+ HRD K SN+L++     +KLCDFG A+ L       G  +++ Y+++R+YRAPE+L  +  YT  +D+WS GC++GEML    +F G+  ++Q+ +++ V+  PS +DV+A+                 SL  +LP         N+ P+ L+LL  +L++NP KR      L H
Sbjct:   61 REIIFLQEFGDHPNIINLRNVLRADNDK----------------DIYL--VFDFMDTDLHAVIRK----GNILKDVHKAYITYQLLKATKYIHSGNVIHRDQKPSNVLLDGECF-VKLCDFGLARSLKQIRDEPGDPALTEYVATRWYRAPEILLASPRYTKGVDMWSVGCIVGEMLLGKAIFPGTSTLNQIERIMSVIPQPSKEDVLAIKSEYGGSVLEKMGRQRQSLESLLP---------NAPPNALDLLKRLLVFNPEKRLTAEEALGH 301          
BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741])

HSP 1 Score: 127.487 bits (319), Expect = 7.343e-34
Identity = 98/335 (29.25%), Postives = 153/335 (45.67%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNG--MILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKEL-IAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLL-----------ELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSL 1108
            + IG+GT+G + KA  + T     D  + K ++     + V   P    RE+ +++ + +HPNIV                            +  L+LV E   + L     +Y  N   + +S+  VK Y +Q+L+ + + H+    HRD+K  NLL+N     +KL DFG A+   +   T    + + +YRAPE+L G ++Y+TA+DVWS GC+  EML    LF G   +DQL ++ R LG+P  D+ +    +     LP   P      FP     DL            +LL  ML Y+P +R      L H  F  L +   +P+L
Sbjct:    8 EKIGEGTYGVVYKARHKMT----GDTVALKKIRLDTETEGV---PSTAIREIALLREL-NHPNIVRL--------------------LDVIHSETKLYLVFEFLDQDLK----KYMDNAPPLGISLPLVKSYMHQLLQGIAFCHAQRTLHRDLKPQNLLINADG-AIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMLTRRALFPGDSEIDQLFRIFRTLGTP--DETVWQGIT----QLPDYKPS-----FPRWCAQDLTKVVPLLDAAGHDLLMQMLQYDPTRRVSAKAALNHHFFHNLEH--HVPTL 296          
BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: RIM11 (Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication [Source:SGD;Acc:S000004747])

HSP 1 Score: 246.899 bits (629), Expect = 1.079e-78
Identity = 136/349 (38.97%), Postives = 201/349 (57.59%), Query Frame = 2
Query:   41 IMSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSF-NICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR 1084
            I+S +   +H P T       +  N  V ++  T +V+G G+FG +    ++ T      NE         AIKKV QD R+KNREL I++ + SH NI+D KY+FY   +                 +IYL+L++E  P+SL   +  + H    +S L +K Y +Q+ ++L YLH F N+CHRDIK  NLLV+  + +LKLCDFGSAK+L     +VSYI SRYYRAPEL+FGA +YT  ID+WS+GCV+ E+L    +F G   +DQLV++I++LG+PS  ++ +MNP+      P + P P+   F        +E L  +L Y+P++R +  + L    FDEL+
Sbjct:   15 IVSKQVYYAHPPPT-------IDPNDPVQISFPTTEVVGHGSFGVVFATVIQET------NEKV-------AIKKVLQDKRFKNRELEIMKML-SHINIIDLKYFFYERDSQ---------------DEIYLNLILEYMPQSLYQRLRHFVHQRTPMSRLEIKYYMFQLFKSLNYLHHFANVCHRDIKPQNLLVDPETWSLKLCDFGSAKQLKPTEPNVSYICSRYYRAPELIFGATNYTNQIDIWSSGCVMAELLLGQPMFPGESGIDQLVEIIKILGTPSKQEICSMNPNYMEHKFPQIKPIPLSRVFKKEDD-QTVEFLADVLKYDPLERFNALQCLCSPYFDELK 326          
BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: MCK1 (Dual-specificity ser/thr and tyrosine protein kinase; roles in chromosome segregation, meiotic entry, genome stability, phosphorylation-dependent protein degradation (Rcn1p and Cdc6p), inhibition of protein kinase A, transcriptional regulation, inhibition of RNA pol III, calcium stress and inhibition of Clb2p-Cdc28p after nuclear division; MCK1 has a paralog, YGK3, that arose from the whole genome duplication [Source:SGD;Acc:S000005251])

HSP 1 Score: 233.032 bits (593), Expect = 2.649e-73
Identity = 139/368 (37.77%), Postives = 197/368 (53.53%), Query Frame = 2
Query:  110 TNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVG--AIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPS--CPPMSLPHVLPCPIKLF---FPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLR-----------DIPSLFSFLPEELSVLDSIEQK 1159
            +N +  + V  ++ IG+G FG + +A +   K +           ++G  AIKKV     YK+REL I+ RI  HPNIV  +Y+F                       +Y HL MEC PE+L   I RY  N + + + H+++YTYQ+ R + YLH   +CHRDIK SN+LV+  +  LK+CDFGSAK+L     S+SYI SR+YRAPEL+ G   YTT ID+W  GCV+GEML    +F G + + QL ++ ++LG P    +   NP+   P  S P       + F   F H S PD ++LL  +L+Y P +R  P R+L H+ F+ELRN              +P+LF F   EL +L     K
Sbjct:   27 SNNTRRMLVKEYRKIGRGAFGTVVQAYLTQDKKN-----------WLGPFAIKKVPAHTEYKSRELQIL-RIADHPNIVKLQYFF--------------THLSPQDNKVYQHLAMECLPETLQIEINRYVTNKLEMPLKHIRLYTYQIARGMLYLHGLGVCHRDIKPSNVLVDPETGVLKICDFGSAKKLEHNQPSISYICSRFYRAPELIIGCTQYTTQIDIWGLGCVMGEMLIGKAIFQGQEPLLQLREIAKLLGPPDKRFIFFSNPAYDGPLFSKPLFSGSSQQRFEKYFGH-SGPDGIDLLMKILVYEPQQRLSPRRILAHQFFNELRNDDTFLPRGFTEPIKLPNLFDFNDFELQILGEFADK 367          
BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: MRK1 (Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication [Source:SGD;Acc:S000002237])

HSP 1 Score: 230.72 bits (587), Expect = 5.069e-71
Identity = 126/323 (39.01%), Postives = 187/323 (57.89%), Query Frame = 2
Query:  119 SVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSF-NICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR 1084
            ++ ++  T +V+G G+FG +    V T   ++N            AIKKV QD RYKNREL  ++ +  HPN V  +YYFY                     ++YL+LV++  P+SL   +  + +  M +  + +K Y YQ+ +AL YLH+   ICHRDIK  NLLV+ ++ + K+CDFGSAK L     +VSYI SRYYRAPEL+FGA +Y+  +DVWS+ CV+ E+L    LF+G   +DQLV++I+++G P+ D++  MNP+      P++ P  +   F     PD L+LLT  L Y+P +R  P + LL   FDE +
Sbjct:  159 TIDISYPTTEVVGHGSFGVV----VTTVIIETNQK---------VAIKKVLQDRRYKNRELETMKML-CHPNTVGLQYYFYEKDEE---------------DEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRDIKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNYSNQVDVWSSACVIAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNIKPITLAEIF-KAEDPDTLDLLTKTLKYHPCERLVPLQCLLSSYFDETK 451          
BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: YGK3 (Protein kinase related to mammalian GSK-3 glycogen synthase kinases; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation; YGK3 has a paralog, MCK1, that arose from the whole genome duplication [Source:SGD;Acc:S000005488])

HSP 1 Score: 183.341 bits (464), Expect = 2.880e-54
Identity = 121/359 (33.70%), Postives = 185/359 (51.53%), Query Frame = 2
Query:  116 QSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVG--AIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYL-HLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLG---SPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLR-----------DIPSLFSFLPEELSVL 1141
            Q   + V   + IG G+FG + ++ +           S+ S++++G  AIK+V + P+ ++ EL I+Q I+ HPN+V  +++F                  +  G +Y  + VME  P++LS  I  Y  NG  +   H+K+YT+Q+LRAL  LHS +ICH D+K SN+L+  SS   K+CDFGSA+ L   T   +Y  SR+YRAPELL  ++ YTT ID+WS GC++GEM++   LF G  A  QL ++ ++LG     S  +   +  S         +      +FP     D +E L  +L Y+  +R    +L+ H  FD LRN              +P LF+F   E   L
Sbjct:   35 QKSKMYVREGKRIGHGSFGTVTQSIL-----------SSNSIEWLGPYAIKRVVKSPKVQSLELEILQNIR-HPNLVTLEFFF------------ESHCTTKDGGHLYQKNFVMEYIPQTLSSEIHEYFDNGSKMPTKHIKLYTFQILRALLTLHSMSICHGDLKPSNILIIPSSGIAKVCDFGSAQRLDDNTELKTYFCSRFYRAPELLLNSKDYTTQIDIWSLGCIIGEMIKGQPLFKGDSANSQLEEIAKLLGRFPKSSIKNSQELQDSLNDQKFKKFMH-----WFPSIEFFD-VEFLLKVLTYDATERCDARQLMAHEFFDALRNETYFLPRGSSMPVHLPDLFNFSASEKRAL 363          
BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Match: KSS1 (Mitogen-activated protein kinase (MAPK); involved in signal transduction pathways that control filamentous growth and pheromone response; regulates septum assembly, and may directly phosphorylate Bni4p; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272])

HSP 1 Score: 145.591 bits (366), Expect = 4.265e-40
Identity = 86/222 (38.74%), Postives = 123/222 (55.41%), Query Frame = 2
Query:  434 LHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTS--------VSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPP---MSLPHVLPCPIKLFFPHNS-QPDLLELLTSMLIYNPIKRSHPTRLLLH 1063
            ++LV E     L  +I   +     LS  HV+ +TYQ+LRAL  +HS  + HRDIK SNLL+N S+  LK+CDFG A+ L + + S          Y+++R+YRAPE++   Q YTTA+D+WS GC+L EM+    LF G D   QL  ++ VLG+PS +D   +          +LP   P P +  +      PD+++LL  ML +NP KR      L H
Sbjct:   90 VYLVEELMETDLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRDIKPSNLLLN-SNCDLKVCDFGLARCLASSSDSRETLVGFMTEYVATRWYRAPEIMLTFQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSFEDFNQIKSKRAKEYIANLPMRPPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRISAAEALRH 310          
BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO36371 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIW0])

HSP 1 Score: 257.299 bits (656), Expect = 9.911e-82
Identity = 142/338 (42.01%), Postives = 199/338 (58.88%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSV 1138
            +VIG G+FG + +A +     DS +         + AIKKV QD R+KNREL I++++  H NIV  +++FYS  + +               +IYL+LV++  PE++  +   Y      + ML++K+Y YQ+ R+L Y+H   ICHRDIK  NLL++  +  LKLCDFGSAK L+ G  +VSYI SRYYRAPEL+FGA  Y+  IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP       P + P P    F   + P+ + L + +L Y P  R +      H  FDELR       N RD+P LF+F P+ELSV
Sbjct:   59 KVIGNGSFGVVYQARM----CDSTE---------LVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRWFFYSSGDKKE--------------EIYLNLVLDFIPETVYRVARHYSKAKQTIPMLYIKLYMYQLFRSLTYIHCLGICHRDIKPQNLLLDPETAVLKLCDFGSAKVLVKGEPNVSYICSRYYRAPELIFGATDYSPDIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIKEMNPHYTEFKFPQIKPHPWNKVFRPKTPPESINLCSRLLEYTPSGRLNAIESCAHCFFDELRDPNTKLPNGRDLPPLFNFTPQELSV 368          
BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO40573 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6R5])

HSP 1 Score: 147.902 bits (372), Expect = 2.150e-40
Identity = 105/334 (31.44%), Postives = 163/334 (48.80%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKA-NVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTS-----VSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPM---SLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFL 1120
            + IG G +G +  A + RT         +  +VK +     V    R  +REL I++  K H NI+  +            +            D+Y+  V++     L  +I    H    L+  HV+ + YQ+LR L Y+HS  + HRD+K SNLLVNE++  LK+ DFG A+ L +           Y+++R+YRAPEL+     Y+ AID+WS GC+L EM+    LF G++ ++QL  ++ V G+PS + +  M           LPH  P P + FFP  + P+ + LL+ ML  +P +R      L H    E  +  D P+ +S L
Sbjct:   27 ETIGNGAYGVVCSAMDTRTG--------AKVAVKKISRAFDVLTTARRTHRELKILRHFK-HDNIICIR------------DILKPPVNLDEFDDVYV--VLDLMESDLHRII----HTDQPLTTEHVRYFLYQILRGLKYIHSAKVLHRDLKPSNLLVNENA-ELKIGDFGMARGLCSSPLEQKRFMTEYVATRWYRAPELMLSLNEYSEAIDMWSVGCILAEMIGRRPLFPGANYLNQLQMILSVTGTPSQNFIERMGAERVKTYLNQLPHKDPVPFEKFFP-KAHPEAINLLSQMLQLDPKERITVENALQHPFLKEYHSEEDEPTCYSPL 331          
BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO37435 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFQ0])

HSP 1 Score: 139.428 bits (350), Expect = 1.439e-37
Identity = 89/232 (38.36%), Postives = 132/232 (56.90%), Query Frame = 2
Query:  509 LSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTS------VSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPP---MSLPHVLPCP-IKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIP---SLFSFLPEELSVLDSIEQKRL 1165
            LS  H+  + YQ+LR L Y+HS N+ HRD+K SNLL+N ++  LK+CDFG A+  IA            Y+++R+YRAPE++  ++ Y+ AID+WS GC+L EML    LF G   +DQL  ++ VLGSP ADD++ +          SLP+    P IKLF   N+    L+L+ ++L +NP KR      L H   ++  +  D P   + F F  E    LD + +++L
Sbjct:  117 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLAR--IADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYSKAIDIWSVGCILAEMLANRPLFPGKHYLDQLNLILNVLGSPIADDLLCIKNEKARSYLQSLPYKPKTPFIKLF--SNADAKALDLIENLLAFNPNKRITVEEALAHPYLEQYYDPADEPVAETPFKFQME----LDDLPKEKL 339          
BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO41403 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4F0])

HSP 1 Score: 133.65 bits (335), Expect = 6.832e-36
Identity = 97/334 (29.04%), Postives = 154/334 (46.11%), Query Frame = 2
Query:  131 NVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQD------PRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSY-ISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSAD---------DVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR 1084
            N    + IG+GT+G + KA  +TT               + A+KK+  D      P    RE+++++ + +HPN+V      ++  +                    L+LV E   + L   +     +G+  S+  +K Y YQ+L  + Y HS  + HRD+K  NLL++++   +KL DFG A+       S ++ + + +YRAPE+L G+++Y T +DVWS GC+  EM     LF G   +DQL ++ R LG+P            D     P  P  S+ HVLP         N+  DLL+    ML Y P  R      L H  F +++
Sbjct:    3 NFEKVEKIGEGTYGVVYKARDKTTGR-------------MVALKKIRLDTESEGVPSTAIREISLLKEL-NHPNVVSLLDVVHNQKS--------------------LYLVFEFLSQDLKKYMDCLPPSGISTSL--IKSYVYQLLSGVAYCHSHRVLHRDLKPQNLLIDKNG-AIKLADFGLARAFGVPVRSYTHEVVTLWYRAPEILLGSRYYATPVDVWSIGCIFAEMKTRRALFPGDSEIDQLFRIFRTLGTPDDKVWPGVSELPDYKTSFPKWPVQSIRHVLPT------LDNTAIDLLQ---KMLTYQPNARISAKAALSHEFFKDVQ 290          
BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Match: EDO30527 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0K0])

HSP 1 Score: 134.035 bits (336), Expect = 5.139e-35
Identity = 86/231 (37.23%), Postives = 121/231 (52.38%), Query Frame = 2
Query:  434 LHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAK--ELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPP----MSLPHVLPCPIKLF-FPHNSQPDLLELLTSMLIYNPIKR-------SHP----TRLLLHRCF 1072
            +++V E     L  +IV    +   L+  HVK++ YQ+LR L YL S  I HRDIK  NLLVN + L LK+CDFG A+  E          + ++YYR+PELL G+ HYT A+D+WS GC+  E+L    LF     V QL ++I +LG+P  +D+     S       +  PH  P    L+   + +  + + LL  ML++NP KR       SHP     RL  H C 
Sbjct:  116 IYVVSELMQSDLHKIIV----SPQPLTADHVKVFLYQILRGLKYLDSAKILHRDIKPGNLLVNSNCL-LKICDFGLARLEEPDESVIMTQEVVTQYYRSPELLTGSTHYTQAVDIWSVGCIFAELLSRKILFQAQSPVQQLNQIIDLLGTPCLEDLSKAGSSEGATKYILQRPHKPPALASLYNLSNQATHEAVHLLCRMLVFNPNKRISCIDALSHPYLDEGRLRFHTCM 341          
BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: gsk3aa (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101168720])

HSP 1 Score: 257.684 bits (657), Expect = 2.988e-81
Identity = 138/338 (40.83%), Postives = 200/338 (59.17%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSV 1138
            +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    ++              ++YL+LV++  PE++  +   ++    I+ +++VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT  ID+WSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       + RD+P LF+F   ELS+
Sbjct:   87 KVIGNGSFGVVYQARLIDTQE-------------MVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSSGEKKD--------------EVYLNLVLDFVPETVYRVARHFNKAKSIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTANIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPASRLSPLEACAHAFFDELRQPNTRLPSGRDLPMLFNFSTTELSI 396          
BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000027319.1 (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101160344])

HSP 1 Score: 256.914 bits (655), Expect = 6.547e-81
Identity = 143/376 (38.03%), Postives = 214/376 (56.91%), Query Frame = 2
Query:   47 SSKFLNSHLPN-----TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSV 1138
            S+ F N  LP      T +V       ++   ++    +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    ++              ++YL+LV++  PE++  +   ++     + +++VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT+ ID+WSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P+ R  P     H  FDELR       + R++P LF+F   ELS+
Sbjct:   49 STSFGNLKLPRDSGKVTTVVATPGQGPDRPQEVSYTDIKVIGNGSFGVVYQARLIDTQE-------------MVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSNGEKKD--------------EVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFFDELRQPNTRLPSGRELPHLFNFSSFELSI 396          
BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000044063.1 (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101160344])

HSP 1 Score: 256.529 bits (654), Expect = 2.943e-80
Identity = 143/376 (38.03%), Postives = 213/376 (56.65%), Query Frame = 2
Query:   47 SSKFLNSHLPN-----TQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNL-------RDIPSLFSFLPEELSV 1138
            S+ F N  LP      T +V       ++   ++    +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    ++              ++YL+LV++  PE++  +   ++     + +++VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT+ ID+WSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P+ R  P     H  FDELR         R++P LF+F   ELS+
Sbjct:   89 STSFGNLKLPRDSGKVTTVVATPGQGPDRPQEVSYTDIKVIGNGSFGVVYQARLIDTQE-------------MVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSNGEKKD--------------EVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFFDELRQPNTRLPSGRELPHLFNFSSFELSI 436          
BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: ENSORLT00000016710.2 (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101160344])

HSP 1 Score: 254.603 bits (649), Expect = 5.059e-80
Identity = 136/338 (40.24%), Postives = 199/338 (58.88%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNL-------RDIPSLFSFLPEELSV 1138
            +VIG G+FG + +A +  T+              + AIKKV QD R+KNREL I++++  H NIV  +Y+FYS    +               ++YL+LV++  PE++  +   ++     + +++VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT+ ID+WSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P+ R  P     H  FDELR         R++P LF+F   ELS+
Sbjct:   91 KVIGNGSFGVVYQARLIDTQE-------------MVAIKKVLQDKRFKNRELQIMRKL-DHCNIVRLRYFFYSNGEKK--------------DEVYLNLVLDFVPETVYRVARHFNKAKTTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPVTRLSPLEACAHAFFDELRQPNTRLPSGRELPHLFNFSSFELSI 400          
BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Match: gsk3aa (glycogen synthase kinase-3 beta [Source:NCBI gene;Acc:101168720])

HSP 1 Score: 236.113 bits (601), Expect = 2.746e-73
Identity = 122/291 (41.92%), Postives = 176/291 (60.48%), Query Frame = 2
Query:  287 KNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSV 1138
            KNREL I++++  H NIV  +Y+FYS    ++              ++YL+LV++  PE++  +   ++    I+ +++VK+Y YQ+ R+L Y+HS  +CHRDIK  NLLV+  +  LKLCDFGSAK+L+ G  +VSYI SRYYRAPEL+FGA  YT  ID+WSAGCVL E+L    +F G   VDQLV++I+VLG+P+ + +  MNP+      P +   P    F   + P+ + L + +L Y P  R  P     H  FDELR       + RD+P LF+F   ELS+
Sbjct:   87 KNRELQIMRKL-DHCNIVRLRYFFYSSGEKKD--------------EVYLNLVLDFVPETVYRVARHFNKAKSIIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPETAILKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTANIDIWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRLLEYTPASRLSPLEACAHAFFDELRQPNTRLPSGRDLPMLFNFSTTELSI 362          
BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000019899.1 (SMESG000019899.1)

HSP 1 Score: 738.028 bits (1904), Expect = 0.000e+0
Identity = 379/379 (100.00%), Postives = 379/379 (100.00%), Query Frame = 2
Query:   44 MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM 1180
            MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYSMINNENSNSSNQMSKKQSSGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM
Sbjct:    1 MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYSMINNENSNSSNQMSKKQSSGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLRDIPSLFSFLPEELSVLDSIEQKRLIEMVM 379          
BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000023764.1 (SMESG000023764.1)

HSP 1 Score: 263.077 bits (671), Expect = 1.809e-83
Identity = 142/337 (42.14%), Postives = 197/337 (58.46%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            ++IG G+FG + +A    +K              + AIKKV QD R+KNREL I++++K H NIV+  ++FYS    +               ++YL+LV+E  PE++  +   YH N   + +L +K+Y YQ++R+L Y+H+  ICHRDIK  NLLV+  +  LKLCDFGSAK L  G  +VSYI SRYYRAPEL+FGA  YT  IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+PS + +  MNP+      PH+   P    F   +QP+ +EL+  +L Y P  R  P     H  FDELR       N + +P LF+F   E+ 
Sbjct:   55 KIIGNGSFGVVYQARFCESKE-------------LVAIKKVLQDRRFKNRELQIMRQLK-HQNIVELLFFFYSNGEKK--------------DEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIG 363          
BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000023764.1 (SMESG000023764.1)

HSP 1 Score: 263.462 bits (672), Expect = 2.307e-83
Identity = 142/337 (42.14%), Postives = 197/337 (58.46%), Query Frame = 2
Query:  146 QVIGQGTFGYIEKANVRTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELS 1135
            ++IG G+FG + +A    +K              + AIKKV QD R+KNREL I++++K H NIV+  ++FYS    +               ++YL+LV+E  PE++  +   YH N   + +L +K+Y YQ++R+L Y+H+  ICHRDIK  NLLV+  +  LKLCDFGSAK L  G  +VSYI SRYYRAPEL+FGA  YT  IDVWSAGCVL E+L    +F G   VDQLV++I+VLG+PS + +  MNP+      PH+   P    F   +QP+ +EL+  +L Y P  R  P     H  FDELR       N + +P LF+F   E+ 
Sbjct:   55 KIIGNGSFGVVYQARFCESKE-------------LVAIKKVLQDRRFKNRELQIMRQLK-HQNIVELLFFFYSNGEKK--------------DEVYLNLVLEFIPETVYRVARHYHKNKQTIPLLFIKLYMYQLMRSLAYIHNLGICHRDIKPQNLLVDPDTGVLKLCDFGSAKMLQRGEPNVSYICSRYYRAPELIFGATDYTCQIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPSREQIHQMNPNYTEFKFPHIKAHPWNKVFRPRTQPEAIELVAKLLEYTPSTRVSPIESCTHSFFDELRQESTKLPNDKPLPPLFNFASNEIG 363          
BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000012496.1 (SMESG000012496.1)

HSP 1 Score: 233.032 bits (593), Expect = 8.969e-74
Identity = 121/286 (42.31%), Postives = 174/286 (60.84%), Query Frame = 2
Query:  314 RIKSHPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSVLDSI 1150
            ++  HPN++   YYF                      D YL+L+ME  P+++ DL+ +Y  N  ++   +VKI++YQMLR L Y+H   I HRDIK +NLLVN  +  LKLCDFGSAK L++G  +V+YI SR+YRAPEL+ G+ +YT AIDVWSAGCV+ EML    LF+G + +DQLV++I+++GSPSA+ +  MN +     LP + P P +  F     P+++ LLT +L Y+PI+R      L++  F+ELR       N    PSL  F  EEL++  S+
Sbjct:    2 KMLQHPNVIALLYYF---------------IHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 272          
BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Match: SMESG000012496.1 (SMESG000012496.1)

HSP 1 Score: 232.646 bits (592), Expect = 1.215e-73
Identity = 121/282 (42.91%), Postives = 172/282 (60.99%), Query Frame = 2
Query:  326 HPNIVDFKYYFYXXXXXXXXXXXXXXXXXXXXGDIYLHLVMECFPESLSDLIVRYHHNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLKLCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVLGEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVLPCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELR-------NLRDIPSLFSFLPEELSVLDSI 1150
            HPN++   YYF                      D YL+L+ME  P+++ DL+ +Y  N  ++   +VKI++YQMLR L Y+H   I HRDIK +NLLVN  +  LKLCDFGSAK L++G  +V+YI SR+YRAPEL+ G+ +YT AIDVWSAGCV+ EML    LF+G + +DQLV++I+++GSPSA+ +  MN +     LP + P P +  F     P+++ LLT +L Y+PI+R      L++  F+ELR       N    PSL  F  EEL++  S+
Sbjct:    4 HPNVIALLYYF---------------IHNGEKDDTYLNLIMEYIPDTVYDLVRKYRQNRTVIPSQYVKIFSYQMLRGLAYMHFKQIVHRDIKPTNLLVNMETGILKLCDFGSAKILVSGQPNVAYICSRFYRAPELILGSANYTCAIDVWSAGCVIAEMLLGRALFSGQNNIDQLVEIIKIMGSPSANQIREMNSTYNEFKLPKMSPIPFEKLFSDKVDPEVIHLLTHLLEYSPIQRLTSLESLVYTYFNELRESSFRLPNGGKSPSLLDFSLEELTIKPSL 270          
The following BLAST results are available for this feature:
BLAST of glycogen synthase kinase 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
GSK3A3.541e-8439.84glycogen synthase kinase 3 alpha [Source:HGNC Symb... [more]
GSK3B4.857e-8442.43glycogen synthase kinase 3 beta [Source:HGNC Symbo... [more]
GSK3A1.873e-8339.84glycogen synthase kinase 3 alpha [Source:HGNC Symb... [more]
GSK3A1.873e-8339.84glycogen synthase kinase 3 alpha [Source:HGNC Symb... [more]
GSK3B4.559e-8342.43glycogen synthase kinase 3 beta [Source:HGNC Symbo... [more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gsk-35.496e-8141.85Glycogen synthase kinase-3 [Source:UniProtKB/Swis... [more]
C44H4.63.875e-6136.13pep chromosome:WBcel235:X:14596476:14599158:-1 gen... [more]
mpk-17.186e-3836.86Mitogen-activated protein kinase mpk-1 [Source:Un... [more]
mpk-12.050e-3737.23Mitogen-activated protein kinase mpk-1 [Source:Un... [more]
Y106G6D.42.742e-3629.04pep chromosome:WBcel235:I:10114759:10116583:1 gene... [more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gskt5.074e-8038.67gene:FBgn0046332 transcript:FBtr0085784[more]
sgg1.015e-7839.18gene:FBgn0003371 transcript:FBtr0070475[more]
sgg1.130e-7839.18gene:FBgn0003371 transcript:FBtr0070469[more]
sgg1.130e-7839.18gene:FBgn0003371 transcript:FBtr0070472[more]
sgg1.130e-7839.18gene:FBgn0003371 transcript:FBtr0070473[more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gsk3ba3.579e-8442.73glycogen synthase kinase 3 beta, genome duplicate ... [more]
gsk3ab1.622e-8241.12glycogen synthase kinase 3 alpha b [Source:ZFIN;Ac... [more]
gsk3bb1.897e-8241.84glycogen synthase kinase 3 beta, genome duplicate ... [more]
gsk3aa1.629e-7940.24glycogen synthase kinase 3 alpha a [Source:ZFIN;Ac... [more]
mapk35.540e-4038.14mitogen-activated protein kinase 3 [Source:ZFIN;Ac... [more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
GSK3B5.369e-8442.14glycogen synthase kinase 3 beta [Source:NCBI gene;... [more]
GSK3B8.573e-8442.14glycogen synthase kinase 3 beta [Source:NCBI gene;... [more]
GSK3B2.117e-8342.14glycogen synthase kinase 3 beta [Source:NCBI gene;... [more]
GSK3B2.192e-8241.99glycogen synthase kinase 3 beta [Source:NCBI gene;... [more]
GSK3B4.101e-8141.04glycogen synthase kinase 3 beta [Source:NCBI gene;... [more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Gsk3a2.801e-8440.00glycogen synthase kinase 3 alpha [Source:MGI Symbo... [more]
Gsk3b3.960e-8442.43glycogen synthase kinase 3 beta [Source:MGI Symbol... [more]
Gsk3a4.072e-8440.00glycogen synthase kinase 3 alpha [Source:MGI Symbo... [more]
Gsk3b1.606e-8141.03glycogen synthase kinase 3 beta [Source:MGI Symbol... [more]
Mapk19.196e-4037.29mitogen-activated protein kinase 1 [Source:MGI Sym... [more]
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BLAST of glycogen synthase kinase 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P18265|GSK3A_RAT8.620e-8540.11Glycogen synthase kinase-3 alpha OS=Rattus norvegi... [more]
sp|Q10452|GSK3_SCHPO6.089e-8441.21Protein kinase gsk3 OS=Schizosaccharomyces pombe (... [more]
sp|Q39019|KSG10_ARATH8.023e-8443.92Shaggy-related protein kinase kappa OS=Arabidopsis... [more]
sp|Q2NL51|GSK3A_MOUSE1.960e-8340.00Glycogen synthase kinase-3 alpha OS=Mus musculus O... [more]
sp|P49841|GSK3B_HUMAN2.332e-8342.43Glycogen synthase kinase-3 beta OS=Homo sapiens OX... [more]
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BLAST of glycogen synthase kinase 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
Q1WBW10.000e+099.74Glycogen synthase kinase 3 OS=Schmidtea mediterran... [more]
A4USB20.000e+070.35Glycogen synthase kinase 3 OS=Girardia tigrina OX=... [more]
D2DJU11.642e-141100.00Gsk3-like protein OS=Schmidtea mediterranea OX=793... [more]
A0A183SGQ03.442e-11849.62Protein kinase domain-containing protein OS=Schist... [more]
A0A0X3PHU58.806e-11849.62Protein kinase domain-containing protein (Fragment... [more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gsk3ba2.420e-8442.73glycogen synthase kinase 3 beta [Source:NCBI gene;... [more]
ENSAMXT00000005621.22.431e-8442.73glycogen synthase kinase-3 beta-like [Source:NCBI ... [more]
ENSAMXT00000036323.12.884e-8442.73glycogen synthase kinase-3 beta-like [Source:NCBI ... [more]
gsk3ba1.511e-8242.09glycogen synthase kinase 3 beta [Source:NCBI gene;... [more]
gsk3aa2.114e-8240.83glycogen synthase kinase-3 alpha-like [Source:NCBI... [more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mapk12.085e-3937.66mitogen-activated protein kinase 1 [Source:ZFIN;Ac... [more]
cdk27.652e-3729.62cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
mapk159.063e-3631.87mitogen-activated protein kinase 15 [Source:ZFIN;A... [more]
mapk152.043e-3531.87mitogen-activated protein kinase 15 [Source:ZFIN;A... [more]
cdk27.343e-3429.25cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GEN... [more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
RIM111.079e-7838.97Protein kinase; required for signal transduction d... [more]
MCK12.649e-7337.77Dual-specificity ser/thr and tyrosine protein kina... [more]
MRK15.069e-7139.01Glycogen synthase kinase 3 (GSK-3) homolog; one of... [more]
YGK32.880e-5433.70Protein kinase related to mammalian GSK-3 glycogen... [more]
KSS14.265e-4038.74Mitogen-activated protein kinase (MAPK); involved ... [more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO363719.911e-8242.01Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO405732.150e-4031.44Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO374351.439e-3738.36Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO414036.832e-3629.04Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO305275.139e-3537.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of glycogen synthase kinase 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gsk3aa2.988e-8140.83glycogen synthase kinase-3 beta [Source:NCBI gene;... [more]
ENSORLT00000027319.16.547e-8138.03glycogen synthase kinase-3 beta [Source:NCBI gene;... [more]
ENSORLT00000044063.12.943e-8038.03glycogen synthase kinase-3 beta [Source:NCBI gene;... [more]
ENSORLT00000016710.25.059e-8040.24glycogen synthase kinase-3 beta [Source:NCBI gene;... [more]
gsk3aa2.746e-7341.92glycogen synthase kinase-3 beta [Source:NCBI gene;... [more]
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BLAST of glycogen synthase kinase 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000019899.10.000e+0100.00SMESG000019899.1[more]
SMESG000023764.11.809e-8342.14SMESG000023764.1[more]
SMESG000023764.12.307e-8342.14SMESG000023764.1[more]
SMESG000012496.18.969e-7442.31SMESG000012496.1[more]
SMESG000012496.11.215e-7342.91SMESG000012496.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30029226
GenBankABD72512.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30029226 ID=SMED30029226|Name=glycogen synthase kinase 3|organism=Schmidtea mediterranea sexual|type=transcript|length=1299bp
ATCTATATAAATCTTATATGATTAGACCTAGTTTCTATAGATTATGAGCT
CTAAATTTTTAAATTCACATCTTCCAAATACTCAAATAGTAAATGGATTT
CAAATGCACACAAATCAATCAGTCACACTTAACGTCAATACATTTCAAGT
AATTGGCCAAGGAACTTTTGGATATATTGAAAAAGCTAACGTAAGAACAA
CGAAGTCTGATAGTAACGACAATGAAAGTGCCAAATCTGTGAAATTTGTT
GGAGCTATAAAAAAAGTTCACCAAGACCCAAGATATAAAAATCGAGAATT
AAATATCATTCAGCGCATTAAATCTCATCCAAATATCGTGGACTTCAAAT
ATTATTTCTATAGTATGATTAACAATGAAAACTCAAACAGCAGTAATCAG
ATGTCTAAAAAACAGTCTTCTGGAGATATTTATCTTCATCTTGTTATGGA
ATGTTTCCCTGAAAGTTTGTCTGATTTGATTGTTCGTTATCATCACAATG
GAATGATATTATCAATGCTGCATGTTAAAATCTATACTTATCAGATGTTG
CGCGCGCTTGGCTACTTGCATTCCTTCAATATTTGTCACAGGGATATTAA
ATCATCAAACCTTCTTGTCAACGAGTCTTCCTTAACATTGAAATTGTGCG
ATTTCGGAAGTGCTAAAGAATTAATAGCTGGCACAACAAGTGTCAGTTAC
ATCAGTTCCAGGTACTACCGAGCCCCGGAGCTGCTATTCGGTGCCCAGCA
TTACACGACTGCCATTGACGTGTGGAGTGCCGGCTGCGTGCTGGGGGAAA
TGCTGCGGATGGGCTGCCTGTTTACCGGGAGCGACGCCGTCGATCAGCTG
GTCAAGGTTATCCGAGTGCTCGGAAGCCCCTCTGCCGATGACGTCATAGC
AATGAATCCCAGCTGCCCCCCCATGAGTCTCCCTCATGTGCTTCCGTGTC
CAATCAAGCTGTTCTTCCCTCACAACTCCCAGCCGGACCTGCTGGAATTG
CTCACATCGATGCTCATTTACAACCCCATCAAGCGCTCGCATCCAACTCG
GCTGCTTCTCCATCGCTGCTTTGACGAGTTGCGCAACTTGCGTGACATTC
CCAGCCTGTTCTCATTTTTGCCCGAGGAATTGAGCGTGCTCGACAGCATA
GAGCAGAAACGGTTAATCGAGATGGTCATGTAGTGGTCTACCTCGCTACT
GCTCTCCCAGACAGGTGGCGTTTGTACAGGGAGCAATGTTGTATCATTGT
TATCACCACCACCACCACCACCATTATCTGCCATTTGTATTCATTAATA
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protein sequence of SMED30029226-orf-1

>SMED30029226-orf-1 ID=SMED30029226-orf-1|Name=SMED30029226-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=380bp
MSSKFLNSHLPNTQIVNGFQMHTNQSVTLNVNTFQVIGQGTFGYIEKANV
RTTKSDSNDNESAKSVKFVGAIKKVHQDPRYKNRELNIIQRIKSHPNIVD
FKYYFYSMINNENSNSSNQMSKKQSSGDIYLHLVMECFPESLSDLIVRYH
HNGMILSMLHVKIYTYQMLRALGYLHSFNICHRDIKSSNLLVNESSLTLK
LCDFGSAKELIAGTTSVSYISSRYYRAPELLFGAQHYTTAIDVWSAGCVL
GEMLRMGCLFTGSDAVDQLVKVIRVLGSPSADDVIAMNPSCPPMSLPHVL
PCPIKLFFPHNSQPDLLELLTSMLIYNPIKRSHPTRLLLHRCFDELRNLR
DIPSLFSFLPEELSVLDSIEQKRLIEMVM*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000044cephalic ganglia
PLANA:0000097ventral nerve cord
PLANA:0000103central nervous system
PLANA:0002109X1 cell
PLANA:0002111X2 cell
PLANA:0002142parenchyma
Vocabulary: INTERPRO
TermDefinition
IPR039192STKc_GSK3
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0004672protein kinase activity
GO:0016301kinase activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 31..343
e-value: 3.5E-62
score: 222.6
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 33..342
e-value: 2.5E-50
score: 171.3
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 31..343
score: 37.149
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 141..378
e-value: 4.0E-58
score: 198.7
NoneNo IPR availableGENE3DG3DSA:3.30.200.20coord: 29..139
e-value: 5.0E-17
score: 63.4
NoneNo IPR availablePANTHERPTHR24057GLYCOGEN SYNTHASE KINASE-3 ALPHAcoord: 24..375
NoneNo IPR availablePANTHERPTHR24057:SF0PROTEIN KINASE SHAGGY-RELATEDcoord: 24..375
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 180..192
IPR039192Glycogen synthase kinase 3, catalytic domainCDDcd14137STKc_GSK3coord: 26..346
e-value: 4.91896E-159
score: 446.179
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 28..368