SMED30029134
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029134 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 4
Alignments
SMED30029134 aligns in the following genomic locations:
Homology
BLAST of SMED30029134 vs. Ensembl Human
Match: DNASE2 (deoxyribonuclease 2, lysosomal [Source:HGNC Symbol;Acc:HGNC:2960]) HSP 1 Score: 77.0258 bits (188), Expect = 6.776e-17 Identity = 39/125 (31.20%), Postives = 68/125 (54.40%), Query Frame = -2 Query: 59 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGK---KYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKDIREIFK 421 D+Y+ ++A L ++ V+ + S+C ++V NV I+ G + ST+DH KW VS + P+ C+GD+NR + +RGGG+LC + +W FQ +V+ +PC + + +K Sbjct: 237 DLYSGWLAAALGTNLQVQFWHKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCVSP--KGPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPCNGMARKPSRAYK 359
BLAST of SMED30029134 vs. Ensembl Human
Match: DNASE2B (deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:HGNC:28875]) HSP 1 Score: 66.6254 bits (161), Expect = 3.326e-14 Identity = 41/112 (36.61%), Postives = 63/112 (56.25%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKST-QDHCKWAVST-SIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 DI+A +MA +LK + E+ + + S+C Y VYN+++I + Y S+ QDH KW +S + + CIGD+NR Q R GG +C +N +I+ FQ +V E C Sbjct: 41 DIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESC 152
BLAST of SMED30029134 vs. Ensembl Human
Match: DNASE2B (deoxyribonuclease 2 beta [Source:HGNC Symbol;Acc:HGNC:28875]) HSP 1 Score: 66.2402 bits (160), Expect = 3.889e-13 Identity = 41/112 (36.61%), Postives = 63/112 (56.25%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKST-QDHCKWAVST-SIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 DI+A +MA +LK + E+ + + S+C Y VYN+++I + Y S+ QDH KW +S + + CIGD+NR Q R GG +C +N +I+ FQ +V E C Sbjct: 249 DIFAAWMAQRLKTHLLTETWQRKRQELPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQKGTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQGLVLYYESC 360
BLAST of SMED30029134 vs. Ensembl Celegans
Match: crn-7 (Cell-death-related nuclease 7 [Source:UniProtKB/Swiss-Prot;Acc:P34387]) HSP 1 Score: 92.0485 bits (227), Expect = 7.673e-23 Identity = 44/111 (39.64%), Postives = 69/111 (62.16%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX--XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 DI+ D ++ + K+++ VES I ++C S + ++V + + G + S++DH KWAVS S P VC GD+NR SQ KRGGG+LC++N +W L+ V ++EPC Sbjct: 232 DIWNDLISRQNKVTLAVESWLNGSGDDIHTTCTSTSQTHDVTEMRVTGLNFASSKDHSKWAVSNSQTNPIVCFGDMNRQKSQLKRGGGALCIQNRNLWQLYHSFVIQVEPC 342
BLAST of SMED30029134 vs. Ensembl Celegans
Match: nuc-1 (Deoxyribonuclease-2 [Source:UniProtKB/Swiss-Prot;Acc:Q17778]) HSP 1 Score: 69.707 bits (169), Expect = 9.404e-15 Identity = 40/106 (37.74%), Postives = 59/106 (55.66%), Query Frame = -2 Query: 107 DIYADFMAPKLKISMDVXXXXXXXXXXXSCQSKYKVYNVRSISIDGKK-YKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVRE 421 D+Y +AP LK + VE+W R S I C+ Y + SI + + T+DH K A S + P+VCIGD+NRM SQ+ RGGG+ C+ + +W + I + Sbjct: 266 DLYDTLVAPTLKTDLVVETWRRGSEIPLDCKLTYHANDALSIHVGSTTAFSYTKDHSKMAHSADMTKPWVCIGDINRMTSQYVRGGGTTCISSSFLWKAYSVIATQ 371
BLAST of SMED30029134 vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508]) HSP 1 Score: 64.3142 bits (155), Expect = 8.694e-13 Identity = 45/126 (35.71%), Postives = 66/126 (52.38%), Query Frame = -2 Query: 89 DIYADFMAPKLKISMDVXXXXXXXXXXXSCQSKYKVYNVRSI----------SIDGKKYKSTQDHCKWAV-----STSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPK 421 D+Y+DF+ P LK S+ VE+W S E + S +V+S +ID Y S +DH K+ V S+ P+VCIGD+NR Q RGGG++C+ + + + F I+ E PC K Sbjct: 236 DLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAID---YSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCTK 358
BLAST of SMED30029134 vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508]) HSP 1 Score: 64.3142 bits (155), Expect = 8.694e-13 Identity = 45/126 (35.71%), Postives = 66/126 (52.38%), Query Frame = -2 Query: 89 DIYADFMAPKLKISMDVXXXXXXXXXXXSCQSKYKVYNVRSI----------SIDGKKYKSTQDHCKWAV-----STSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPK 421 D+Y+DF+ P LK S+ VE+W S E + S +V+S +ID Y S +DH K+ V S+ P+VCIGD+NR Q RGGG++C+ + + + F I+ E PC K Sbjct: 236 DLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAID---YSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCTK 358
BLAST of SMED30029134 vs. Ensembl Celegans
Match: crn-6 (Cell death-related nuclease 6 [Source:UniProtKB/Swiss-Prot;Acc:P34508]) HSP 1 Score: 64.3142 bits (155), Expect = 8.861e-13 Identity = 45/126 (35.71%), Postives = 66/126 (52.38%), Query Frame = -2 Query: 89 DIYADFMAPKLKISMDVXXXXXXXXXXXSCQSKYKVYNVRSI----------SIDGKKYKSTQDHCKWAV-----STSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPK 421 D+Y+DF+ P LK S+ VE+W S E + S +V+S +ID Y S +DH K+ V S+ P+VCIGD+NR Q RGGG++C+ + + + F I+ E PC K Sbjct: 236 DLYSDFVGPTLKSSIKVETWNHQSGDEYNLPSVCDPNHVQSTMSAKYIRLPYAID---YSSYEDHSKFVVAYSESSSKPPIPYVCIGDINRQSHQIHRGGGTMCIYDQETYFQFANIISETVPCTK 358
BLAST of SMED30029134 vs. Ensembl Fly
Match: DNaseII (gene:FBgn0000477 transcript:FBtr0083538) HSP 1 Score: 70.4774 bits (171), Expect = 6.486e-15 Identity = 43/125 (34.40%), Postives = 71/125 (56.80%), Query Frame = -2 Query: 89 LDIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISID--GKKYKSTQDHCKWAVSTSIEY----------PFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPK 424 +++YAD +AP L +S+ VE+ + + +SC KV NV SIS +K+TQDH KWAVS ++C+GD+NR Q RGGG++C K+ ++ +L++++V + C + Sbjct: 240 VELYADVVAPTLDVSLFVEAWRDGAGNLPNSCDKSDKVLNVESISNPELSVDFKTTQDHSKWAVSRPTGILIYHWRVGGGDWICVGDINRQEGQLHRGGGTVCHKSARVSNLYRQLVTNYDKCAQ 364
BLAST of SMED30029134 vs. Ensembl Zebrafish
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:ZDB-GENE-010724-16]) HSP 1 Score: 63.929 bits (154), Expect = 1.777e-12 Identity = 38/113 (33.63%), Postives = 67/113 (59.29%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGK-KYKSTQDHCKWAVSTSIEYP--FVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y ++AP L+ ++ V+ + + S C ++V N+ IS K +K+T+DH KWAVS+S +VC+GD+NR ++ KRGGG++C ++ +W ++ + E C Sbjct: 241 DLYHSWVAPTLQSNLLVQFWRRSTGILPSDCSPNWEVLNIDLISPGQKVTFKATEDHSKWAVSSSSGTSGGWVCVGDINRDEAEEKRGGGTVCRRDAVVWKAYRSAALQCESC 353
BLAST of SMED30029134 vs. Ensembl Zebrafish
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:ZDB-GENE-010724-16]) HSP 1 Score: 63.929 bits (154), Expect = 1.777e-12 Identity = 38/113 (33.63%), Postives = 67/113 (59.29%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGK-KYKSTQDHCKWAVSTSIEYP--FVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y ++AP L+ ++ V+ + + S C ++V N+ IS K +K+T+DH KWAVS+S +VC+GD+NR ++ KRGGG++C ++ +W ++ + E C Sbjct: 241 DLYHSWVAPTLQSNLLVQFWRRSTGILPSDCSPNWEVLNIDLISPGQKVTFKATEDHSKWAVSSSSGTSGGWVCVGDINRDEAEEKRGGGTVCRRDAVVWKAYRSAALQCESC 353
BLAST of SMED30029134 vs. Ensembl Zebrafish
Match: dnase2b (deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GENE-090824-2]) HSP 1 Score: 46.595 bits (109), Expect = 2.028e-6 Identity = 36/111 (32.43%), Postives = 63/111 (56.76%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKK-YKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 DIY ++A L + VES ++ ++ S+C + V N+ ++ + G + ++S +DH KW VS + + + C+GD+NR Q RGGG C +N I+ F+K + + C Sbjct: 238 DIYTGWVAQALGTDLLVESWLHQAHQLPSNCSLPWHVMNINAVCLPGPQMFRSYEDHSKWCVSYTFKDQWTCLGDLNRDGGQAGRGGGLTCCQNSVIYKAFRKAMARYKHC 348
BLAST of SMED30029134 vs. Ensembl Zebrafish
Match: dnase2b (deoxyribonuclease II beta [Source:ZFIN;Acc:ZDB-GENE-090824-2]) HSP 1 Score: 46.595 bits (109), Expect = 2.148e-6 Identity = 36/111 (32.43%), Postives = 63/111 (56.76%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKK-YKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 DIY ++A L + VES ++ ++ S+C + V N+ ++ + G + ++S +DH KW VS + + + C+GD+NR Q RGGG C +N I+ F+K + + C Sbjct: 227 DIYTGWVAQALGTDLLVESWLHQAHQLPSNCSLPWHVMNINAVCLPGPQMFRSYEDHSKWCVSYTFKDQWTCLGDLNRDGGQAGRGGGLTCCQNSVIYKAFRKAMARYKHC 337
BLAST of SMED30029134 vs. Ensembl Xenopus
Match: dnase2b (deoxyribonuclease II beta [Source:NCBI gene;Acc:496759]) HSP 1 Score: 74.3294 bits (181), Expect = 4.164e-16 Identity = 43/117 (36.75%), Postives = 70/117 (59.83%), Query Frame = -2 Query: 74 DIYADFMAPKLKISMDVXXXXXXXXXXXSCQSKYKVYNVRSISIDGKK-YKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKDI 421 DI+A ++A KL+ +M VESW ++ S+C +Y VYN+ I + + +++ DH KW VS S E + CIGD+NR +Q +R GG +C +N I++ F+ +V + C + I Sbjct: 224 DIFAAWIAQKLRTNMLVESWQSRQQLSSNCSLQYHVYNINRIGLPTQSTFQTFYDHSKWCVSQSNEDLWTCIGDLNRHPAQTRRSGGFICTQNKHIYTAFRNMVLYYKNCTDTEYKI 340
BLAST of SMED30029134 vs. Ensembl Xenopus
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:NCBI gene;Acc:733868]) HSP 1 Score: 56.225 bits (134), Expect = 1.510e-9 Identity = 25/81 (30.86%), Postives = 41/81 (50.62%), Query Frame = -2 Query: 95 CQSKYKVYNVRSISID-GKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 334 C + YN+ I I + + DH KW V+ + C+GD+NR + +RGGG++CV + +W F+ +V C Sbjct: 265 CSLPFHTYNIMEIDISCAYSFSTHNDHSKWCVTDGAGW--ACVGDMNRDVKEERRGGGTVCVNDPNVWKSFRSLVSSYNNC 343
BLAST of SMED30029134 vs. Ensembl Mouse
Match: Dnase2a (deoxyribonuclease II alpha [Source:MGI Symbol;Acc:MGI:1329019]) HSP 1 Score: 70.0922 bits (170), Expect = 1.277e-14 Identity = 34/113 (30.09%), Postives = 62/113 (54.87%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKK---YKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y+ ++A L ++ V+ + S+C Y+V +V G + +T+DH KW V+ + P+ C+GD+NR ++ RGGG++C + W FQ +V++ +PC Sbjct: 218 DLYSGWLAEALGTNLQVQFWQNSPGILPSNCSGAYQVLDVTQTGFPGPSRLTFSATEDHSKWCVAP--QGPWACVGDMNRNKAETHRGGGTVCTQLPSFWKAFQSLVKDWKPC 328
BLAST of SMED30029134 vs. Ensembl Mouse
Match: Dnase2a (deoxyribonuclease II alpha [Source:MGI Symbol;Acc:MGI:1329019]) HSP 1 Score: 69.707 bits (169), Expect = 1.539e-14 Identity = 34/113 (30.09%), Postives = 62/113 (54.87%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKK---YKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y+ ++A L ++ V+ + S+C Y+V +V G + +T+DH KW V+ + P+ C+GD+NR ++ RGGG++C + W FQ +V++ +PC Sbjct: 239 DLYSGWLAEALGTNLQVQFWQNSPGILPSNCSGAYQVLDVTQTGFPGPSRLTFSATEDHSKWCVAP--QGPWACVGDMNRNKAETHRGGGTVCTQLPSFWKAFQSLVKDWKPC 349
BLAST of SMED30029134 vs. Ensembl Mouse
Match: Dnase2b (deoxyribonuclease II beta [Source:MGI Symbol;Acc:MGI:1913283]) HSP 1 Score: 67.3958 bits (163), Expect = 1.327e-13 Identity = 41/105 (39.05%), Postives = 58/105 (55.24%), Query Frame = -2 Query: 116 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKKY-KSTQDHCKWAVST-SIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKI 421 DI+ ++A KLK + ++ + + S+C Y VYN++SI + K Y S QDH KW VS + CIGD+NR Q RGGG +C KN I+ F K+ Sbjct: 242 DIFTGWIAQKLKTHLLAQTWQKKKQELPSNCSLPYHVYNIKSIGVTSKSYFSSRQDHSKWCVSIKGSANRWTCIGDLNRSLHQALRGGGFICTKNHYIYQAFHKL 346
BLAST of SMED30029134 vs. Ensembl Mouse
Match: Dnase2b (deoxyribonuclease II beta [Source:MGI Symbol;Acc:MGI:1913283]) HSP 1 Score: 67.3958 bits (163), Expect = 1.327e-13 Identity = 41/105 (39.05%), Postives = 58/105 (55.24%), Query Frame = -2 Query: 116 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKKY-KSTQDHCKWAVST-SIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKI 421 DI+ ++A KLK + ++ + + S+C Y VYN++SI + K Y S QDH KW VS + CIGD+NR Q RGGG +C KN I+ F K+ Sbjct: 242 DIFTGWIAQKLKTHLLAQTWQKKKQELPSNCSLPYHVYNIKSIGVTSKSYFSSRQDHSKWCVSIKGSANRWTCIGDLNRSLHQALRGGGFICTKNHYIYQAFHKL 346
BLAST of SMED30029134 vs. UniProt/SwissProt
Match: sp|P34387|TG198_CAEEL (Cell-death-related nuclease 7 OS=Caenorhabditis elegans OX=6239 GN=crn-7 PE=2 SV=2) HSP 1 Score: 92.0485 bits (227), Expect = 9.761e-22 Identity = 44/111 (39.64%), Postives = 69/111 (62.16%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX--XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 DI+ D ++ + K+++ VES I ++C S + ++V + + G + S++DH KWAVS S P VC GD+NR SQ KRGGG+LC++N +W L+ V ++EPC Sbjct: 232 DIWNDLISRQNKVTLAVESWLNGSGDDIHTTCTSTSQTHDVTEMRVTGLNFASSKDHSKWAVSNSQTNPIVCFGDMNRQKSQLKRGGGALCIQNRNLWQLYHSFVIQVEPC 342
BLAST of SMED30029134 vs. UniProt/SwissProt
Match: sp|Q75WF2|DNA2_ACAPL (Plancitoxin-1 OS=Acanthaster planci OX=133434 PE=1 SV=1) HSP 1 Score: 78.1814 bits (191), Expect = 1.294e-16 Identity = 35/81 (43.21%), Postives = 50/81 (61.73%), Query Frame = -2 Query: 95 CQSKYKVYNVRSISIDG-KKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 334 C++ VYNV+ +S+ G +K T+DH KWAV+T + CIG +NR SQ RGGG++C++N + F V E EPC Sbjct: 277 CEAGLNVYNVKKVSLSGGSDFKGTKDHSKWAVTTKSGLKWTCIGGINRQTSQMYRGGGAVCLENANVHKAFYDSVAEYEPC 357
BLAST of SMED30029134 vs. UniProt/SwissProt
Match: sp|O00115|DNS2A_HUMAN (Deoxyribonuclease-2-alpha OS=Homo sapiens OX=9606 GN=DNASE2 PE=1 SV=2) HSP 1 Score: 77.0258 bits (188), Expect = 3.254e-16 Identity = 39/125 (31.20%), Postives = 68/125 (54.40%), Query Frame = -2 Query: 59 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGK---KYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKDIREIFK 421 D+Y+ ++A L ++ V+ + S+C ++V NV I+ G + ST+DH KW VS + P+ C+GD+NR + +RGGG+LC + +W FQ +V+ +PC + + +K Sbjct: 237 DLYSGWLAAALGTNLQVQFWHKTVGILPSNCSDIWQVLNVNQIAFPGPAGPSFNSTEDHSKWCVSP--KGPWTCVGDMNRNQGEEQRGGGTLCAQLPALWKAFQPLVKNYQPCNGMARKPSRAYK 359
BLAST of SMED30029134 vs. UniProt/SwissProt
Match: sp|Q9QZK8|DNS2A_RAT (Deoxyribonuclease-2-alpha OS=Rattus norvegicus OX=10116 GN=Dnase2 PE=2 SV=1) HSP 1 Score: 70.4774 bits (171), Expect = 5.585e-14 Identity = 35/113 (30.97%), Postives = 62/113 (54.87%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISI---DGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y+ ++A L ++ V+ + S+C +K+ +V G + +T+DH KW V+ E P+VC+GD+NR + RGGG+LC + +W F+ +V+ +PC Sbjct: 240 DLYSGWLAAALGTNLQVQFWPNSPGILPSNCSGTHKILDVTETGFPGPSGPTFNATEDHSKWCVAP--EGPWVCVGDMNRNKRETHRGGGTLCTQVPALWKAFRSLVKACKPC 350
BLAST of SMED30029134 vs. UniProt/SwissProt
Match: sp|P56542|DNS2A_MOUSE (Deoxyribonuclease-2-alpha OS=Mus musculus OX=10090 GN=Dnase2 PE=1 SV=1) HSP 1 Score: 69.707 bits (169), Expect = 1.076e-13 Identity = 34/113 (30.09%), Postives = 62/113 (54.87%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKK---YKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y+ ++A L ++ V+ + S+C Y+V +V G + +T+DH KW V+ + P+ C+GD+NR ++ RGGG++C + W FQ +V++ +PC Sbjct: 239 DLYSGWLAEALGTNLQVQFWQNSPGILPSNCSGAYQVLDVTQTGFPGPSRLTFSATEDHSKWCVAP--QGPWACVGDMNRNKAETHRGGGTVCTQLPSFWKAFQSLVKDWKPC 349
BLAST of SMED30029134 vs. TrEMBL
Match: A0A0B2W4P7 (Cell-death-related nuclease 7 OS=Toxocara canis OX=6265 GN=crn-7 PE=4 SV=1) HSP 1 Score: 114.005 bits (284), Expect = 3.453e-27 Identity = 55/110 (50.00%), Postives = 77/110 (70.00%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 DIY++ +APKL+ S+ E+ + SSC S YKV N+ S+ IDGK++KS++DH KWAVS P +CIGD+NR SQ KRGGG++C++N ++W L+ V EIEPC Sbjct: 260 DIYSELLAPKLRTSLLTETWLNGPGDLPSSCSSTYKVNNIVSVLIDGKQFKSSKDHSKWAVSADKRNPMLCIGDINRQKSQSKRGGGTVCIRNAQLWHLYNGSVDEIEPC 369
BLAST of SMED30029134 vs. TrEMBL
Match: A0A0M3KCV0 (Cell-death-related nuclease 7 (inferred by orthology to a C. elegans protein) OS=Anisakis simplex OX=6269 PE=4 SV=1) HSP 1 Score: 103.219 bits (256), Expect = 7.659e-26 Identity = 44/105 (41.90%), Postives = 73/105 (69.52%), Query Frame = -2 Query: 95 FMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 406 +AP++K S+ E+ + +S C SKY V N+ S+++DG ++K+++DH KWA+S + P +CIGD+NR SQ KRGGG++C+ ND++W L+ K + ++PC Sbjct: 1 LVAPEMKTSLFTETWMNGPNDFDSECSSKYTVNNIESLNVDGNQFKNSKDHSKWAISVDEKEPLLCIGDINRQKSQMKRGGGTVCILNDRLWGLYNKTIVNVQPC 105
BLAST of SMED30029134 vs. TrEMBL
Match: A0A3P6TGL9 (Uncharacterized protein OS=Anisakis simplex OX=6269 GN=ASIM_LOCUS18198 PE=4 SV=1) HSP 1 Score: 103.219 bits (256), Expect = 9.420e-26 Identity = 44/105 (41.90%), Postives = 73/105 (69.52%), Query Frame = -2 Query: 95 FMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 406 +AP++K S+ E+ + +S C SKY V N+ S+++DG ++K+++DH KWA+S + P +CIGD+NR SQ KRGGG++C+ ND++W L+ K + ++PC Sbjct: 1 MVAPEMKTSLFTETWMNGPNDFDSECSSKYTVNNIESLNVDGNQFKNSKDHSKWAISVDEKEPLLCIGDINRQKSQMKRGGGTVCILNDRLWGLYNKTIVNVQPC 105
BLAST of SMED30029134 vs. TrEMBL
Match: F1L824 (Cell-death-related nuclease 7 OS=Ascaris suum OX=6253 PE=2 SV=1) HSP 1 Score: 109.383 bits (272), Expect = 1.424e-25 Identity = 53/133 (39.85%), Postives = 84/133 (63.16%), Query Frame = -2 Query: 56 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC----------PKLQKDIREIFKD 421 D+Y+D +AP+LK S+ E+ + S C S YKV NV S+ +DG ++ +++DH KWAVS P +CIGD+NR SQ+ RGGG++C++N ++WSL++ + E EPC +L K I+ +F++ Sbjct: 239 DLYSDLVAPQLKTSLLTETWLNGPGDLPSICSSPYKVNNVLSVRVDGNQFANSKDHSKWAVSADGTDPVLCIGDINRQKSQWGRGGGTVCIRNTQVWSLYKGSITETEPCDGVTNHPNWSTRLWKRIKGVFQN 371
BLAST of SMED30029134 vs. TrEMBL
Match: A0A443S164 (Plancitoxin-1-like protein (Fragment) OS=Leptotrombidium deliense OX=299467 GN=B4U80_02519 PE=4 SV=1) HSP 1 Score: 101.679 bits (252), Expect = 3.058e-24 Identity = 51/121 (42.15%), Postives = 73/121 (60.33%), Query Frame = -2 Query: 89 DIYADFMAPKLK--ISMDVXXXXXXXXXXXSCQSKYKVYNVRSISIDGK--------KYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPK 421 D+Y ++AP LK +S++ + S+C S YK+ NV ++ + K ++ TQDH KWAV+T+ PFVCI D+NRM SQFKRGGGSLC + +W F I++ +E CPK Sbjct: 72 DLYGAYIAPSLKNDLSVETWRRGAGGPLTSNCSSTYKIINVDTLEMKFKGGNIFTTDEWLYTQDHAKWAVTTASISPFVCIADINRMESQFKRGGGSLCFNDSDVWKQFNDIIKGVEACPK 192
BLAST of SMED30029134 vs. Ensembl Cavefish
Match: dnase2 (deoxyribonuclease-2-alpha-like [Source:NCBI gene;Acc:103028211]) HSP 1 Score: 73.9442 bits (180), Expect = 4.572e-16 Identity = 41/111 (36.94%), Postives = 67/111 (60.36%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGK-KYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y ++AP L+ + V+ + +ES C YKV N++ +S K +KST+DH KWA S S ++ VC+GD+NR ++ KRGGG++C KN +W ++ + + C Sbjct: 247 DLYHSWVAPALQADLLVQFWRRSTGILESDCDPSYKVLNIQLLSPGQKLTFKSTEDHSKWAASVSGDW--VCVGDINRNEAEEKRGGGTVCHKNAVVWKAYRATALQCDSC 355
BLAST of SMED30029134 vs. Ensembl Cavefish
Match: dnase2b (deoxyribonuclease 2 beta [Source:NCBI gene;Acc:103030372]) HSP 1 Score: 61.6178 bits (148), Expect = 1.023e-11 Identity = 36/111 (32.43%), Postives = 62/111 (55.86%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISI-DGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 DIYA ++A L+ + VES + ++ S+C Y V N++ + + + + S +DH KW VS + C+GD+NR +Q RGGG +C +N ++ F++ V + C Sbjct: 255 DIYAGWVAQTLRTDLLVESWQRDNHQLPSNCSLPYHVLNIKRVHLPENITFSSYEDHSKWCVSVEFRAQWTCLGDLNRESTQAYRGGGLICSQNPVVYKAFRQAVAWFKGC 365
BLAST of SMED30029134 vs. Ensembl Sea Lamprey
Match: dnase2 (deoxyribonuclease II, lysosomal [Source:ZFIN;Acc:ZDB-GENE-010724-16]) HSP 1 Score: 75.0998 bits (183), Expect = 3.232e-17 Identity = 43/120 (35.83%), Postives = 65/120 (54.17%), Query Frame = -2 Query: 77 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDG-KKYKSTQDHCKWAVSTSIEYP---FVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKD 421 D+Y +AP LK S+ +ES +S+C ++ V V SIS+ + S +DH KW VS + P + C+GD+NR + RGGG++C + IW+ F K +EPCP +D Sbjct: 214 DLYVHLVAPNLKSSLYLESWVHGVGVFDSNCSGEFCVCRVSSISLPSVAPFSSEEDHSKWCVSQTGGSPGGAWACVGDINRNRGEEYRGGGTVCTDDPAIWAAFAKATTSVEPCPAGPRD 333
BLAST of SMED30029134 vs. Ensembl Medaka
Match: ENSORLT00000036979.1 (deoxyribonuclease-2-alpha [Source:NCBI gene;Acc:101173852]) HSP 1 Score: 62.3882 bits (150), Expect = 5.500e-12 Identity = 27/79 (34.18%), Postives = 46/79 (58.23%), Query Frame = -2 Query: 86 YKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKL 322 + VYNV+++ + + + T DH KW V++ + C+ D+NR SQ RGGG+LC+ + ++ F+ + EPC L Sbjct: 271 HHVYNVKTVKLLKRDFNDTVDHSKWCVTSDENW--TCVADMNRETSQMGRGGGALCMDSYEVAKAFRSTISAYEPCQTL 347
BLAST of SMED30029134 vs. Ensembl Medaka
Match: dnase2 (deoxyribonuclease 2, lysosomal [Source:NCBI gene;Acc:101162954]) HSP 1 Score: 61.2326 bits (147), Expect = 1.253e-11 Identity = 35/116 (30.17%), Postives = 65/116 (56.03%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGK-KYKSTQDHCKWAVSTSIEYP-----FVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y ++AP L+ + V+ + + S C +KV ++ I+ +K++QDH KWAVS + +VC+GD+NR ++ KRGGG++C+++ +W ++ + E C Sbjct: 246 DLYHGWVAPALQSDLLVQFWIRSTGILPSDCSLGWKVLDITLINPGQTFAFKNSQDHSKWAVSPKQAWGGKGGGWVCVGDINRNEAEEKRGGGTVCLQDPVVWKAYRSAALQCEAC 361
BLAST of SMED30029134 vs. Ensembl Medaka
Match: dnase2b (deoxyribonuclease-2-beta [Source:NCBI gene;Acc:101174093]) HSP 1 Score: 53.9138 bits (128), Expect = 4.839e-9 Identity = 35/105 (33.33%), Postives = 56/105 (53.33%), Query Frame = -2 Query: 113 DIYADFMAPKLKISMDVXX-XXXXXXXXXSCQSKYKVYNVRSISIDGK-KYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIV 421 DIY ++A L + VES + + S+C N++ I + +++S DH KW VS + E C+GD+NR +Q RGGG +C N I+ F+++V Sbjct: 242 DIYTGWVAQVLDTDLLVESWQTQGRVLPSNCSLPRHAMNIKRIQLPTLVRFQSYYDHSKWCVSQAYEDQVTCLGDLNRERAQLWRGGGLICSDNPVIYKAFRQLV 346
BLAST of SMED30029134 vs. Planmine SMEST
Match: SMESG000081053.1 (SMESG000081053.1) HSP 1 Score: 216.468 bits (550), Expect = 7.287e-74 Identity = 119/119 (100.00%), Postives = 119/119 (100.00%), Query Frame = -2 Query: 47 MAPKLKISMDVXXXXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKDIREIFKDIIL 403 MAPKLKISMDVESWIRSSRIESSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKDIREIFKDIIL Sbjct: 1 MAPKLKISMDVESWIRSSRIESSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKDIREIFKDIIL 119
BLAST of SMED30029134 vs. Planmine SMEST
Match: SMESG000081053.1 (SMESG000081053.1) HSP 1 Score: 201.06 bits (510), Expect = 5.714e-68 Identity = 111/111 (100.00%), Postives = 111/111 (100.00%), Query Frame = -2 Query: 47 MDVXXXXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKDIREIFKDIIL 379 MDVESWIRSSRIESSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKDIREIFKDIIL Sbjct: 1 MDVESWIRSSRIESSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKLQKDIREIFKDIIL 111
BLAST of SMED30029134 vs. Planmine SMEST
Match: SMESG000062993.1 (SMESG000062993.1) HSP 1 Score: 118.627 bits (296), Expect = 7.189e-33 Identity = 58/112 (51.79%), Postives = 81/112 (72.32%), Query Frame = -2 Query: 86 DIYADFMAPKLKISMDVXXXXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPCPKL 421 D+Y+ +AP L+ S+ VESWIR +++S+C + Y VYNV +++ G K++ + DH KWAVS + + P+VCIGD+NRM SQFKRGGG+LCVKN IW +FQ IV + E C Sbjct: 227 DLYSGLVAPGLQASIMVESWIRGEKVDSTCGTDYHVYNVEKVNLPGAKFRESHDHSKWAVSNNQDSPYVCIGDINRMTSQFKRGGGTLCVKNKNIWKIFQPIVADFEKCANF 338
BLAST of SMED30029134 vs. Planmine SMEST
Match: SMESG000062594.1 (SMESG000062594.1) HSP 1 Score: 105.916 bits (263), Expect = 3.837e-28 Identity = 56/111 (50.45%), Postives = 75/111 (67.57%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX--XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y+ +AP L S+ VE+ R S+++S+C+ KYKV NV I++ K +KST DH KWA+S S P++CIGD+NRM SQFKRGGGSLC N IW F K ++ E C Sbjct: 232 DLYSKLIAPTLNGSLFVETWRNGRGSKLDSACELKYKVNNVEEINLSNKSFKSTSDHSKWAISQSKSSPYICIGDINRMESQFKRGGGSLCTSNVNIWEKFYKSIKTYEKC 342
BLAST of SMED30029134 vs. Planmine SMEST
Match: SMESG000081036.1 (SMESG000081036.1) HSP 1 Score: 94.7449 bits (234), Expect = 5.394e-24 Identity = 52/111 (46.85%), Postives = 69/111 (62.16%), Query Frame = -2 Query: 95 DIYADFMAPKLKISMDVXX--XXXXXXXXXSCQSKYKVYNVRSISIDGKKYKSTQDHCKWAVSTSIEYPFVCIGDVNRMYSQFKRGGGSLCVKNDKIWSLFQKIVREIEPC 421 D+Y+ +AP+LK S+ VES R S+CQ YKVYN++++ I G + +DH KWAV+ S CIGD+NRM SQF RGGGSLC + +WS F K V + E C Sbjct: 210 DLYSVLIAPQLKESLFVESWLNGNGGREPSNCQLTYKVYNIKTVKILGVEINDVRDHSKWAVTLSNATSATCIGDINRMESQFYRGGGSLCFIHANVWSAFNKAVSDYEKC 320 The following BLAST results are available for this feature:
BLAST of SMED30029134 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 3
BLAST of SMED30029134 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of SMED30029134 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 1
BLAST of SMED30029134 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 4
BLAST of SMED30029134 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 2
BLAST of SMED30029134 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 4
BLAST of SMED30029134 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of SMED30029134 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of SMED30029134 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of SMED30029134 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of SMED30029134 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of SMED30029134 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of SMED30029134 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 3
BLAST of SMED30029134 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029134 ID=SMED30029134|Name=SMED30029134|organism=Schmidtea mediterranea sexual|type=transcript|length=425bpback to top protein sequence of SMED30029134-orf-1 >SMED30029134-orf-1 ID=SMED30029134-orf-1|Name=SMED30029134-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=127bp LDIYADFMAPKLKISMDVESWIRSSRIESSCQSKYKVYNVRSISIDGKKYback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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