Gamma-secretase subunit PEN-2
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Homology
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Human
Match: PSENEN (presenilin enhancer, gamma-secretase subunit [Source:HGNC Symbol;Acc:HGNC:30100]) HSP 1 Score: 82.0333 bits (201), Expect = 1.277e-18 Identity = 41/99 (41.41%), Postives = 60/99 (60.61%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVS-RLMQISS-LTFNVPLG 871 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ AF + EQ QIK YV S +G W + + +WI +Q+ R + L+F +PLG Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Human
Match: PSENEN (presenilin enhancer, gamma-secretase subunit [Source:HGNC Symbol;Acc:HGNC:30100]) HSP 1 Score: 82.0333 bits (201), Expect = 1.277e-18 Identity = 41/99 (41.41%), Postives = 60/99 (60.61%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVS-RLMQISS-LTFNVPLG 871 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ AF + EQ QIK YV S +G W + + +WI +Q+ R + L+F +PLG Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIKGYVWRSAVGFLFWVIVLTSWITIFQIYRPRWGALGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Human
Match: AD000671.1 (novel protein) HSP 1 Score: 63.5438 bits (153), Expect = 1.516e-12 Identity = 27/54 (50.00%), Postives = 37/54 (68.52%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIK 742 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ AF + EQ QIK Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIK 54
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Human
Match: PSENEN (presenilin enhancer, gamma-secretase subunit [Source:HGNC Symbol;Acc:HGNC:30100]) HSP 1 Score: 64.6994 bits (156), Expect = 1.891e-12 Identity = 27/54 (50.00%), Postives = 37/54 (68.52%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIK 742 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ AF + EQ QIK Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLVPAYTEQSQIK 54
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Celegans
Match: pen-2 (Gamma-secretase subunit pen-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9U357]) HSP 1 Score: 70.4774 bits (171), Expect = 7.717e-15 Identity = 36/99 (36.36%), Postives = 56/99 (56.57%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSR--LMQISSLTFNVPLG 871 MDI+ ++ +K+ +CKKYF G LP +W++N+ WFF AF + QI++YVI S++G+ W + + W I +Q L+ LTF P G Sbjct: 1 MDISKLTDVKKVDLCKKYFLIGACFLPLVWIVNTFWFFSDAFCKPINAHRRQIRKYVIASIVGSIFWIIVLSAWEIFFQHYRAQGLVWTDFLTFVFPTG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Fly
Match: pen-2 (gene:FBgn0053198 transcript:FBtr0340331) HSP 1 Score: 87.0409 bits (214), Expect = 1.116e-20 Identity = 43/100 (43.00%), Postives = 57/100 (57.00%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSRLMQISS--LTFNVPLGG 874 MDI+ KL +C+KYF+ G LPF+W IN WFF AF F EQ QIKRYVI S +GT W + + WII +Q ++ ++F +PLG Sbjct: 1 MDISKAPNPRKLELCRKYFFAGFAFLPFVWAINVCWFFTEAFHKPPFSEQSQIKRYVIYSAVGTLFWLIVLTAWIIIFQTNRTAWGATADYMSFIIPLGS 100
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Fly
Match: pen-2 (gene:FBgn0053198 transcript:FBtr0089842) HSP 1 Score: 87.0409 bits (214), Expect = 1.116e-20 Identity = 43/100 (43.00%), Postives = 57/100 (57.00%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSRLMQISS--LTFNVPLGG 874 MDI+ KL +C+KYF+ G LPF+W IN WFF AF F EQ QIKRYVI S +GT W + + WII +Q ++ ++F +PLG Sbjct: 1 MDISKAPNPRKLELCRKYFFAGFAFLPFVWAINVCWFFTEAFHKPPFSEQSQIKRYVIYSAVGTLFWLIVLTAWIIIFQTNRTAWGATADYMSFIIPLGS 100
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Zebrafish
Match: psenen (presenilin enhancer, gamma-secretase subunit [Source:NCBI gene;Acc:402810]) HSP 1 Score: 84.3445 bits (207), Expect = 1.338e-19 Identity = 41/99 (41.41%), Postives = 60/99 (60.61%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMV-SRLMQISS-LTFNVPLG 871 M++ + EKLS+C++Y+ GG LPF+WL+N LWFFK AF + EQ QIK YV S +G W + TWI +Q ++ ++ L+F +PLG Sbjct: 1 MNLERIPNEEKLSLCRRYYLGGFAFLPFLWLVNILWFFKEAFLKPAYTEQPQIKSYVKKSALGLLLWVAVLTTWITVFQHFRAQWGEVGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Zebrafish
Match: psenen (presenilin enhancer, gamma-secretase subunit [Source:NCBI gene;Acc:402810]) HSP 1 Score: 84.3445 bits (207), Expect = 1.338e-19 Identity = 41/99 (41.41%), Postives = 60/99 (60.61%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMV-SRLMQISS-LTFNVPLG 871 M++ + EKLS+C++Y+ GG LPF+WL+N LWFFK AF + EQ QIK YV S +G W + TWI +Q ++ ++ L+F +PLG Sbjct: 1 MNLERIPNEEKLSLCRRYYLGGFAFLPFLWLVNILWFFKEAFLKPAYTEQPQIKSYVKKSALGLLLWVAVLTTWITVFQHFRAQWGEVGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Xenopus
Match: psenen (presenilin enhancer, gamma-secretase subunit [Source:NCBI gene;Acc:549090]) HSP 1 Score: 79.337 bits (194), Expect = 1.040e-17 Identity = 41/99 (41.41%), Postives = 56/99 (56.57%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSRLMQISS--LTFNVPLG 871 M++ V EKL +C+KY+ GG LPF+WL+N +WFFK AF + EQ I+ YV S +G W V + TWI YQ + L+F +PLG Sbjct: 1 MNLERVPNEEKLQLCRKYYLGGFALLPFLWLVNVVWFFKEAFFKPAYTEQPLIQSYVKRSALGLFVWVVILTTWISVYQTHRAGWGATGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Mouse
Match: Psenen (presenilin enhancer gamma secretase subunit [Source:MGI Symbol;Acc:MGI:1913590]) HSP 1 Score: 84.7297 bits (208), Expect = 8.675e-20 Identity = 43/99 (43.43%), Postives = 61/99 (61.62%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMV-SRLMQISS-LTFNVPLG 871 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ AF A + EQ QIK YV S +G W + + TWI +Q+ R + L+F +PLG Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLAPAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQIYRPRWGALGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Mouse
Match: Psenen (presenilin enhancer gamma secretase subunit [Source:MGI Symbol;Acc:MGI:1913590]) HSP 1 Score: 84.7297 bits (208), Expect = 8.675e-20 Identity = 43/99 (43.43%), Postives = 61/99 (61.62%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMV-SRLMQISS-LTFNVPLG 871 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ AF A + EQ QIK YV S +G W + + TWI +Q+ R + L+F +PLG Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLAPAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQIYRPRWGALGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Mouse
Match: Psenen (presenilin enhancer gamma secretase subunit [Source:MGI Symbol;Acc:MGI:1913590]) HSP 1 Score: 81.2629 bits (199), Expect = 1.407e-18 Identity = 37/80 (46.25%), Postives = 52/80 (65.00%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQM 820 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ AF A + EQ QIK YV S +G W + + TWI +Q+ Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLAPAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQI 80
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Mouse
Match: Psenen (presenilin enhancer gamma secretase subunit [Source:MGI Symbol;Acc:MGI:1913590]) HSP 1 Score: 48.521 bits (114), Expect = 1.488e-7 Identity = 21/41 (51.22%), Postives = 30/41 (73.17%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLA 703 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ A Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREA 41
BLAST of Gamma-secretase subunit PEN-2 vs. UniProt/SwissProt
Match: sp|Q86BE9|PEN2_DROME (Gamma-secretase subunit pen-2 OS=Drosophila melanogaster OX=7227 GN=pen-2 PE=1 SV=3) HSP 1 Score: 87.0409 bits (214), Expect = 1.119e-19 Identity = 43/100 (43.00%), Postives = 57/100 (57.00%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSRLMQISS--LTFNVPLGG 874 MDI+ KL +C+KYF+ G LPF+W IN WFF AF F EQ QIKRYVI S +GT W + + WII +Q ++ ++F +PLG Sbjct: 1 MDISKAPNPRKLELCRKYFFAGFAFLPFVWAINVCWFFTEAFHKPPFSEQSQIKRYVIYSAVGTLFWLIVLTAWIIIFQTNRTAWGATADYMSFIIPLGS 100
BLAST of Gamma-secretase subunit PEN-2 vs. UniProt/SwissProt
Match: sp|Q6QI68|PEN2_RAT (Gamma-secretase subunit PEN-2 OS=Rattus norvegicus OX=10116 GN=Psenen PE=3 SV=1) HSP 1 Score: 85.5001 bits (210), Expect = 3.718e-19 Identity = 44/99 (44.44%), Postives = 61/99 (61.62%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMV-SRLMQISS-LTFNVPLG 871 M++ VS EKL++C+KY+ GG LPF+WL+N WFFK AF A + EQ QIK YV S +G W + + TWI +Q+ R + L+F +PLG Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFKEAFFAPAYTEQSQIKGYVWRSAVGFLFWVIVLTTWITIFQIYRPRWGALGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. UniProt/SwissProt
Match: sp|Q9CQR7|PEN2_MOUSE (Gamma-secretase subunit PEN-2 OS=Mus musculus OX=10090 GN=Psenen PE=1 SV=1) HSP 1 Score: 84.7297 bits (208), Expect = 6.068e-19 Identity = 43/99 (43.43%), Postives = 61/99 (61.62%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMV-SRLMQISS-LTFNVPLG 871 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ AF A + EQ QIK YV S +G W + + TWI +Q+ R + L+F +PLG Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFLAPAYTEQSQIKGYVWRSAVGFLFWVIILATWITIFQIYRPRWGALGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. UniProt/SwissProt
Match: sp|Q8JHF0|PEN2_DANRE (Gamma-secretase subunit PEN-2 OS=Danio rerio OX=7955 GN=psenen PE=3 SV=1) HSP 1 Score: 84.3445 bits (207), Expect = 1.010e-18 Identity = 41/99 (41.41%), Postives = 60/99 (60.61%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMV-SRLMQISS-LTFNVPLG 871 M++ + EKLS+C++Y+ GG LPF+WL+N LWFFK AF + EQ QIK YV S +G W + TWI +Q ++ ++ L+F +PLG Sbjct: 1 MNLERIPNEEKLSLCRRYYLGGFAFLPFLWLVNILWFFKEAFLKPAYTEQPQIKSYVKKSALGLLLWVAVLTTWITVFQHFRAQWGEVGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. UniProt/SwissProt
Match: sp|Q5G235|PEN2_BOVIN (Gamma-secretase subunit PEN-2 OS=Bos taurus OX=9913 GN=PSENEN PE=3 SV=1) HSP 1 Score: 82.8037 bits (203), Expect = 2.995e-18 Identity = 42/99 (42.42%), Postives = 60/99 (60.61%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVS-RLMQISS-LTFNVPLG 871 M++ VS EKL++C+KY+ GG LPF+WL+N WFF+ AF + EQ QIK YV S +G W + + TWI +Q+ R + L+F +PLG Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFREAFIVPAYTEQSQIKGYVWRSAVGFFLWVIVLSTWITIFQIYRPRWGALGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. TrEMBL
Match: A0A3S0ZZ85 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_013386 PE=4 SV=1) HSP 1 Score: 98.2117 bits (243), Expect = 2.191e-21 Identity = 43/80 (53.75%), Postives = 56/80 (70.00%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQM 820 MD+ V+ +EKL +C++Y+ GG LPF+WLINS+WFFK AF Q+ EQ QIK YVI SMIG W A+ TWI +Q+ Sbjct: 1 MDLRRVNNAEKLVMCRRYYLGGFLVLPFLWLINSVWFFKEAFMKPQYTEQAQIKSYVIRSMIGCVVWLAALITWITIFQL 80
BLAST of Gamma-secretase subunit PEN-2 vs. TrEMBL
Match: A0A2C9JEK1 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106055139 PE=4 SV=1) HSP 1 Score: 96.2857 bits (238), Expect = 1.196e-20 Identity = 44/99 (44.44%), Postives = 64/99 (64.65%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQM--VSRLMQISSLTFNVPLG 871 MD+ + +KL +C+KY+ G F LPF+WL+N++WFFK AF+ + EQ +I+ YV S+IG+ W AI TW+I +Q+ VS LTF +PLG Sbjct: 1 MDLQKLKNEDKLILCRKYYLAGFFLLPFLWLVNAIWFFKEAFRKPHYAEQSEIRTYVTRSIIGSAIWLAAIITWVIIFQLNRVSWGATGDLLTFVIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. TrEMBL
Match: A0A1I8IIK8 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 99.3673 bits (246), Expect = 6.033e-20 Identity = 44/80 (55.00%), Postives = 57/80 (71.25%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQM 820 MD++ SG++KL+IC+KY GG F LPF+WL N WFF+ AF A +PEQ QI+R VI S IG+ WTVA+ TW YQ+ Sbjct: 1 MDLSKASGADKLNICRKYTIGGAFLLPFLWLTNFAWFFREAFLAPAYPEQAQIRRLVIISGIGSAIWTVALLTWFCVYQV 80
BLAST of Gamma-secretase subunit PEN-2 vs. TrEMBL
Match: F6VQU7 (Uncharacterized protein OS=Monodelphis domestica OX=13616 GN=PSENEN PE=4 SV=1) HSP 1 Score: 93.2041 bits (230), Expect = 1.769e-19 Identity = 47/99 (47.47%), Postives = 65/99 (65.66%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQM-VSRLMQISS-LTFNVPLG 871 M++ VS EKL++C+KY+ GG LPF+WL+N LWFF+ AF A + EQGQIK YV S +G W VA+ +WI +Q+ +R I L+F +PLG Sbjct: 1 MNLERVSNEEKLNLCRKYYLGGFALLPFLWLVNVLWFFREAFLAPAYEEQGQIKGYVWRSALGLVFWLVALTSWITIFQINRARWGAIGDYLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. TrEMBL
Match: S4RAK4 (Presenilin enhancer, gamma-secretase subunit OS=Petromyzon marinus OX=7757 PE=4 SV=1) HSP 1 Score: 92.8189 bits (229), Expect = 2.520e-19 Identity = 42/99 (42.42%), Postives = 62/99 (62.63%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSRLMQISS--LTFNVPLG 871 M++ V+ +KLS+C+KY+ GG LPF+WL+N++WFFK AF Q+ EQ +IK+YVI S +G WTV + WI YQ + ++F +P G Sbjct: 1 MNLERVTNEDKLSLCRKYYRGGFILLPFLWLVNAIWFFKEAFMKPQYQEQAEIKKYVIRSAVGVLGWTVVLTVWISIYQHFRPQWGATGDYMSFTIPFG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Cavefish
Match: psenen (presenilin enhancer, gamma-secretase subunit [Source:NCBI gene;Acc:103047545]) HSP 1 Score: 82.4185 bits (202), Expect = 4.718e-19 Identity = 40/99 (40.40%), Postives = 61/99 (61.62%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMV-SRLMQISS-LTFNVPLG 871 M++ + EKLS+C+KY+ GG LPF+WL+N +WFFK AF + EQ QIK YV S +G W + TWI +Q ++ +++ ++F +PLG Sbjct: 1 MNLERIPNEEKLSLCRKYYLGGFAFLPFLWLVNCVWFFKEAFVKPAYTEQPQIKTYVKRSALGLLLWVTVLTTWICIFQHFRAQWGEVADYISFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Sea Lamprey
Match: psenen (presenilin enhancer, gamma-secretase subunit [Source:NCBI gene;Acc:402810]) HSP 1 Score: 92.8189 bits (229), Expect = 1.936e-23 Identity = 42/99 (42.42%), Postives = 62/99 (62.63%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSRLMQISS--LTFNVPLG 871 M++ V+ +KLS+C+KY+ GG LPF+WL+N++WFFK AF Q+ EQ +IK+YVI S +G WTV + WI YQ + ++F +P G Sbjct: 1 MNLERVTNEDKLSLCRKYYRGGFILLPFLWLVNAIWFFKEAFMKPQYQEQAEIKKYVIRSAVGVLGWTVVLTVWISIYQHFRPQWGATGDYMSFTIPFG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Nematostella
Match: EDO46097 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR32]) HSP 1 Score: 83.9593 bits (206), Expect = 5.104e-20 Identity = 42/99 (42.42%), Postives = 60/99 (60.61%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQM--VSRLMQISSLTFNVPLG 871 MD+ VS EK+ +C+KY G+ LPF+WL+N++WFF+ AF E FP Q ++ VI S IG + W + TWI+ YQ S +L+F +PLG Sbjct: 1 MDLRKVSDEEKVKLCRKYTLVGLAFLPFLWLVNAIWFFREAFCRESFPGQKSMRSNVIKSFIGFSIWAAGLSTWIVMYQTNRASWGELGDTLSFLIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Medaka
Match: psenen (presenilin enhancer, gamma-secretase subunit [Source:NCBI gene;Acc:101173167]) HSP 1 Score: 79.7221 bits (195), Expect = 4.658e-18 Identity = 40/99 (40.40%), Postives = 60/99 (60.61%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMV-SRLMQI-SSLTFNVPLG 871 M++ + EKL +C+KY+ GG LPF+WL+N +WFF+ AF + EQ QIK YV S +G W + TWI +Q ++ ++ SL+F +PLG Sbjct: 1 MNLERLPNEEKLILCRKYYLGGFAFLPFLWLVNVVWFFREAFVKPAYTEQLQIKAYVKWSAVGLLFWVAVLTTWITIFQHFRAQWGEVGDSLSFTIPLG 99
BLAST of Gamma-secretase subunit PEN-2 vs. Planmine SMEST
Match: SMESG000035771.1 (SMESG000035771.1) HSP 1 Score: 201.06 bits (510), Expect = 3.520e-64 Identity = 98/98 (100.00%), Postives = 98/98 (100.00%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSRLMQISSLTFNVPLGG 874 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSRLMQISSLTFNVPLGG Sbjct: 1 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWIIKYQMVSRLMQISSLTFNVPLGG 98
BLAST of Gamma-secretase subunit PEN-2 vs. Planmine SMEST
Match: SMESG000015815.1 (SMESG000015815.1) HSP 1 Score: 72.0182 bits (175), Expect = 1.985e-15 Identity = 30/69 (43.48%), Postives = 44/69 (63.77%), Query Frame = 2 Query: 599 SGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWI 805 S + KL +C+ YF+ G F LP +W IN +WFF A+ E +PEQ +++ YVI S++G W V I W+ Sbjct: 12 SSAIKLKLCRLYFFVGAFGLPILWFINLMWFFDFAYNEETYPEQKKVQFYVIFSLVGVIAWIVLIIIWM 80
BLAST of Gamma-secretase subunit PEN-2 vs. Planmine SMEST
Match: SMESG000015820.1 (SMESG000015820.1) HSP 1 Score: 71.2478 bits (173), Expect = 3.432e-15 Identity = 33/75 (44.00%), Postives = 43/75 (57.33%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQAEQFPEQGQIKRYVIGSMIGTTCWTVAIFTWI 805 +D+ +S EKL IC+ YF G F LP +WL N WFFK FQ F E+ IK+YV S +G ++ I WI Sbjct: 4 VDLEKISNEEKLKICRNYFIAGFFVLPILWLFNVAWFFKYGFQGPAFAEKFTIKKYVAASALGFCIYSSLIGLWI 78
BLAST of Gamma-secretase subunit PEN-2 vs. Planmine SMEST
Match: SMESG000015821.1 (SMESG000015821.1) HSP 1 Score: 67.3958 bits (163), Expect = 9.554e-14 Identity = 36/75 (48.00%), Postives = 51/75 (68.00%), Query Frame = 2 Query: 581 MDINSVSGSEKLSICKKYFYGGIFCLPFMWLINSLWFFKLAFQ----AEQF-PEQGQIKRYVIGSMIGTTCWTVA 790 ++I ++ +EKL IC++YF G F LP +WLIN WFF+ AF+ EQ PE+ IK+YVIGS+IG W+V+ Sbjct: 4 VNIKLITNAEKLKICRQYFIAGFFLLPSLWLINIFWFFEEAFKNVPDEEQLDPEKLGIKKYVIGSLIG---WSVS 75 The following BLAST results are available for this feature:
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 4
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 1
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 2
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 2
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 1
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 4
BLAST of Gamma-secretase subunit PEN-2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Gamma-secretase subunit PEN-2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of Gamma-secretase subunit PEN-2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of Gamma-secretase subunit PEN-2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029116 ID=SMED30029116|Name=Gamma-secretase subunit PEN-2|organism=Schmidtea mediterranea sexual|type=transcript|length=1247bpback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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