Oxygen-dependent coproporphyrinogen-III oxidase

Overview
NameOxygen-dependent coproporphyrinogen-III oxidase
Smed IDSMED30029098
Length (bp)1454
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Oxygen-dependent coproporphyrinogen-III oxidase (SMED30029098) t-SNE clustered cells

Violin plots show distribution of expression levels for Oxygen-dependent coproporphyrinogen-III oxidase (SMED30029098) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Oxygen-dependent coproporphyrinogen-III oxidase (SMED30029098) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Oxygen-dependent coproporphyrinogen-III oxidase (SMED30029098) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30029098

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
protonephridiaSMED30029098SMESG000039696.1 dd_Smed_v4_2002_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30029098SMESG000039696.1 dd_Smed_v4_2002_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30029098SMESG000039696.1 dd_Smed_v4_2002_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30029098SMESG000039696.1 dd_Smed_v4_2002_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30029098SMESG000014979.1 SMESG000014974.1 Contig4232GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30029098SMESG000039696.1 Contig4232GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
gutSMED30029098SMESG000039696.1 SMED30029098smed_20140614PMID:26457503
Tu et al., 2015		whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30029098SMESG000039696.1 SMED30029098smed_20140614PMID:26457503
Tu et al., 2015		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Human
Match: CPOX (coproporphyrinogen oxidase [Source:HGNC Symbol;Acc:HGNC:2321])

HSP 1 Score: 395.201 bits (1014), Expect = 1.405e-133
Identity = 181/333 (54.35%), Postives = 247/333 (74.17%), Query Frame = 2 
Query:  125 DELIN-TTVWMSESVNEKSELLK-SDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDL-NEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            DEL +  + +M+  V +  EL +     + KME L L+ Q ++C+++ ++DG   F VD+WERK GGGG++CV+ DG VFEKAGV+IS +HG+L+++A  QM++R   L  ++ +  F A G+SSVIHP+NPH P  HFN+RYFE+E+ DG K WWFGGG DLTP +L +EDA+HFHRTLK ACD H    YP++K+WCD YFFIAHR ERRG+GGIFFDD +   +E  F+FVQ+ A A+ PSY+PLV++ C+  +T  ++ WQ +RRGRYVEFNL+YDRGTKFGL TP +RIESILMSLPL A+W Y H   ++ +++ +L VL+ PR+WV
Sbjct:  121 DELAHRCSSFMAPPVTDLGELRRRPGDMKTKMELLILETQAQVCQALAQVDGGANFSVDRWERKEGGGGISCVLQDGCVFEKAGVSISVVHGNLSEEAAKQMRSRGKVLKTKDGKLPFCAMGVSSVIHPKNPHAPTIHFNYRYFEVEEADGNKQWWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHGPDLYPKFKKWCDDYFFIAHRGERRGIGGIFFDDLDSPSKEEVFRFVQSCARAVVPSYIPLVKKHCDDSFTPQEKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPSENSKEAEILEVLRHPRDWV 453
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Human
Match: AC021660.3 (novel transcript)

HSP 1 Score: 83.1889 bits (204), Expect = 2.724e-19
Identity = 37/54 (68.52%), Postives = 45/54 (83.33%), Query Frame = 2 
Query:  872 CNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAK 1033
            C+  +T  ++ WQ +RRGRYVEFNL+YDRGTKFGL TP +RIESILMSLPL A+
Sbjct:    2 CDDSFTPQEKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTAR 55
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Fly
Match: Coprox (gene:FBgn0021944 transcript:FBtr0079352)

HSP 1 Score: 409.068 bits (1050), Expect = 2.805e-140
Identity = 186/329 (56.53%), Postives = 246/329 (74.77%), Query Frame = 2 
Query:  134 INTTVWMSESVNEKSELL-KSDSYRAKMERLCLQVQGELCRSMERIDG-KEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            +NT+ +M+E + +   LL   ++ R +ME L +++Q E CR++E  +   +KF VD+WER  GGGG+TCV+ DG+VFEKAGVNIS + GSL   A+ QM+AR  +L E     FFA G+S+VIHPRNPHVP  HFN+RYFE+E   G+K WWFGGG+DLTP +L E+DA HFH+TLK+ACD HD ++YPR+K+WCD YF I HRNE RG+GGIFFDD +   QEA+F FV + A A+ PSY+PLV +  N+ Y +++R+WQL+RRGRYVEFNL+YDRGTKFGL TP AR ESILMSLPL+A+W Y H+      +  L+ VL+ P++WV
Sbjct:   62 MNTSRFMAEPITDSKALLGDKENMRHRMEILIMEIQAEFCRALEAEENCGQKFKVDRWERPEGGGGITCVLQDGDVFEKAGVNISVVTGSLPPAAVQQMRARGKNLKEGASLPFFASGVSAVIHPRNPHVPTIHFNYRYFEVETAKGEKQWWFGGGTDLTPYYLCEKDASHFHQTLKSACDEHDPTYYPRFKKWCDDYFRIKHRNESRGIGGIFFDDIDSPNQEAAFNFVSSCARAVIPSYVPLVRKHKNREYGNNERQWQLLRRGRYVEFNLIYDRGTKFGLYTPGARYESILMSLPLHARWEYMHEPKSQSEEGKLMKVLKNPKDWV 390
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Fly
Match: Coprox (gene:FBgn0021944 transcript:FBtr0346584)

HSP 1 Score: 409.068 bits (1050), Expect = 2.805e-140
Identity = 186/329 (56.53%), Postives = 246/329 (74.77%), Query Frame = 2 
Query:  134 INTTVWMSESVNEKSELL-KSDSYRAKMERLCLQVQGELCRSMERIDG-KEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            +NT+ +M+E + +   LL   ++ R +ME L +++Q E CR++E  +   +KF VD+WER  GGGG+TCV+ DG+VFEKAGVNIS + GSL   A+ QM+AR  +L E     FFA G+S+VIHPRNPHVP  HFN+RYFE+E   G+K WWFGGG+DLTP +L E+DA HFH+TLK+ACD HD ++YPR+K+WCD YF I HRNE RG+GGIFFDD +   QEA+F FV + A A+ PSY+PLV +  N+ Y +++R+WQL+RRGRYVEFNL+YDRGTKFGL TP AR ESILMSLPL+A+W Y H+      +  L+ VL+ P++WV
Sbjct:   62 MNTSRFMAEPITDSKALLGDKENMRHRMEILIMEIQAEFCRALEAEENCGQKFKVDRWERPEGGGGITCVLQDGDVFEKAGVNISVVTGSLPPAAVQQMRARGKNLKEGASLPFFASGVSAVIHPRNPHVPTIHFNYRYFEVETAKGEKQWWFGGGTDLTPYYLCEKDASHFHQTLKSACDEHDPTYYPRFKKWCDDYFRIKHRNESRGIGGIFFDDIDSPNQEAAFNFVSSCARAVIPSYVPLVRKHKNREYGNNERQWQLLRRGRYVEFNLIYDRGTKFGLYTPGARYESILMSLPLHARWEYMHEPKSQSEEGKLMKVLKNPKDWV 390
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Zebrafish
Match: cpox (coproporphyrinogen oxidase [Source:ZFIN;Acc:ZDB-GENE-030131-9884])

HSP 1 Score: 373.629 bits (958), Expect = 1.873e-125
Identity = 164/310 (52.90%), Postives = 227/310 (73.23%), Query Frame = 2 
Query:  188 KSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDL-NEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            + D    +ME L ++ Q   CR++E++DG   F VD+W RK GGGG++CVM DG +FEKAGVN+S ++G+LT++A  QM++R   L  ++ +  F A G+SSVIHP+NPH+P  HFN+RYFE+E+ DG K WWFGGG+DLTP ++  EDA HFH+TLK ACD H   +YP +K+WCD YF+I HR E RG+GGIFFDD +   Q+  F FV++ A  + P YLP+V +  N  +T ++++WQ +RRGRYVEFNLVYDRG KFGLATP +RIESILMSLPL A+W Y H+     +++ +L +L+ P++W+
Sbjct:  141 RKDEMSTRMEMLIMETQSAFCRALEQVDGGS-FRVDRWSRKEGGGGISCVMQDGKIFEKAGVNVSVVYGNLTEEAARQMRSRGKILKGKDGKLPFRAMGVSSVIHPKNPHIPTVHFNYRYFEIEEADGTKQWWFGGGTDLTPVYIDLEDATHFHKTLKEACDKHHPKYYPDFKKWCDNYFYIRHRGETRGIGGIFFDDLDSPDQDEVFNFVRSCAKTVVPCYLPIVYKHLNDSFTPEEKDWQQVRRGRYVEFNLVYDRGVKFGLATPGSRIESILMSLPLTARWEYMHEPTKGTKEAEMLEILRNPKQWI 449
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Xenopus
Match: mtfr1l (mitochondrial fission regulator 1-like [Source:Xenbase;Acc:XB-GENE-5771531])

HSP 1 Score: 392.504 bits (1007), Expect = 4.314e-133
Identity = 174/308 (56.49%), Postives = 234/308 (75.97%), Query Frame = 2 
Query:  194 DSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDL-NEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            D  +++ME + +  Q E+CR++ + DG   F VD+W+R  GGGG++CV+ DG VFEKAGVN+S +HG L++++I QMK+R   L  ++ +  F A G+SSVIHP+NPHVP  HFN+RYFE+E+ DG + WWFGGG+DLTP +L +ED +HFH+TLK+ACD H  +FYP+YK+WCD YFFI HR E RGVGGIFFDD +   +E  F FV++ A A+ P YLP+VE+  N  +T +++ WQ +RRGRYVEFNLVYDRGTKFGLATP +RIESILMSLPL A+W Y+H   +D ++  +L VL+ PR+WV
Sbjct:  103 DDMKSRMELMIMGTQAEVCRALAQADGAASFTVDRWQRAEGGGGISCVLQDGKVFEKAGVNVSVVHGYLSEESIRQMKSRGKSLKTKDGKLPFCAMGVSSVIHPKNPHVPTIHFNYRYFEIEEADGNRQWWFGGGTDLTPTYLDQEDVVHFHQTLKDACDKHSPTFYPKYKKWCDDYFFINHRGESRGVGGIFFDDLDFASKEELFAFVESCAKAVVPCYLPIVEKHKNDSFTPEEKLWQQLRRGRYVEFNLVYDRGTKFGLATPGSRIESILMSLPLTARWEYNHIPPEDSKEGEILKVLRKPRDWV 410
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Mouse
Match: Cpox (coproporphyrinogen oxidase [Source:MGI Symbol;Acc:MGI:104841])

HSP 1 Score: 394.43 bits (1012), Expect = 1.223e-133
Identity = 180/333 (54.05%), Postives = 245/333 (73.57%), Query Frame = 2 
Query:  125 DELIN-TTVWMSESVNEKSELLK-SDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDL-NEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            DEL    + +MS  V E  EL +  +  + KME + ++ Q ++CR++ ++DG   F VD+WERK GGGG+TCV+ DG VFEKAGV+IS +HG+L+++A  QM+ R   L  ++ +  F A G+SSVIHP+NP+ P  HFN+RYFE+E+ DG   WWFGGG DLTP +L +EDA+HFHRTLK ACD H    YP++K+WCD YFFI HR ERRG+GGIFFDD +   +E +F+FV+T A A+ PSY+P+V++ C+  YT  D+ WQ +RRGRYVEFNL+YDRGTKFGL TP +RIESILMSLPL A+W Y H   ++ +++ +L VL+ P++WV
Sbjct:  110 DELARRCSTFMSSPVTELRELRRRPEDMKTKMELMIMETQAQVCRALAQVDGVADFTVDRWERKEGGGGITCVLQDGRVFEKAGVSISVVHGNLSEEAANQMRGRGKTLKTKDSKLPFTAMGVSSVIHPKNPYAPTMHFNYRYFEVEEADGNTHWWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHGPDIYPKFKKWCDDYFFIVHRGERRGIGGIFFDDLDSPSKEEAFRFVKTCAEAVVPSYVPIVKKHCDDSYTPRDKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPPENSKEAEILEVLRHPKDWV 442
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. UniProt/SwissProt
Match: sp|Q9V3D2|HEM6_DROME (Oxygen-dependent coproporphyrinogen-III oxidase OS=Drosophila melanogaster OX=7227 GN=Coprox PE=2 SV=1)

HSP 1 Score: 409.068 bits (1050), Expect = 2.811e-139
Identity = 186/329 (56.53%), Postives = 246/329 (74.77%), Query Frame = 2 
Query:  134 INTTVWMSESVNEKSELL-KSDSYRAKMERLCLQVQGELCRSMERIDG-KEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            +NT+ +M+E + +   LL   ++ R +ME L +++Q E CR++E  +   +KF VD+WER  GGGG+TCV+ DG+VFEKAGVNIS + GSL   A+ QM+AR  +L E     FFA G+S+VIHPRNPHVP  HFN+RYFE+E   G+K WWFGGG+DLTP +L E+DA HFH+TLK+ACD HD ++YPR+K+WCD YF I HRNE RG+GGIFFDD +   QEA+F FV + A A+ PSY+PLV +  N+ Y +++R+WQL+RRGRYVEFNL+YDRGTKFGL TP AR ESILMSLPL+A+W Y H+      +  L+ VL+ P++WV
Sbjct:   62 MNTSRFMAEPITDSKALLGDKENMRHRMEILIMEIQAEFCRALEAEENCGQKFKVDRWERPEGGGGITCVLQDGDVFEKAGVNISVVTGSLPPAAVQQMRARGKNLKEGASLPFFASGVSAVIHPRNPHVPTIHFNYRYFEVETAKGEKQWWFGGGTDLTPYYLCEKDASHFHQTLKSACDEHDPTYYPRFKKWCDDYFRIKHRNESRGIGGIFFDDIDSPNQEAAFNFVSSCARAVIPSYVPLVRKHKNREYGNNERQWQLLRRGRYVEFNLIYDRGTKFGLYTPGARYESILMSLPLHARWEYMHEPKSQSEEGKLMKVLKNPKDWV 390
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. UniProt/SwissProt
Match: sp|Q3B7D0|HEM6_RAT (Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Rattus norvegicus OX=10116 GN=Cpox PE=1 SV=1)

HSP 1 Score: 402.905 bits (1034), Expect = 4.860e-136
Identity = 186/333 (55.86%), Postives = 247/333 (74.17%), Query Frame = 2 
Query:  125 DELIN-TTVWMSESVNEKSEL-LKSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNE-ELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            DEL    + +MS  V E  EL  + D  + KME + ++ Q ++CR++ ++DG   F VD+WERK GGGG+TCV+ DG VFEKAGVNIS +HG+L+++A  QM++R   L + + +  F A GISSVIHP+NP+ P  HFN+RYFE+E+ DGK  WWFGGG DLTP +L  EDA+HFHRTLK ACD H    YP++K+WCD YFFIAHR ERRG+GGIFFDD +   +E +F+FV+T A A+ PSY+P+V++ C+  YT  D+ WQ +RRGRYVEFNLVYDRGTKFGL TP +RIESILMSLPL A+W Y H   ++ +++ +L VL+ P++WV
Sbjct:  110 DELARRCSTFMSSPVTELRELGRRPDDMKTKMELMIMETQAQVCRALAQVDGVADFSVDRWERKEGGGGITCVLQDGRVFEKAGVNISVVHGNLSEEAANQMRSRGKALKKKDGKLPFTAMGISSVIHPKNPYAPTMHFNYRYFEVEEADGKMHWWFGGGCDLTPTYLNREDAVHFHRTLKEACDQHGPDIYPKFKKWCDDYFFIAHRGERRGIGGIFFDDLDSPSKEEAFRFVKTCAEAVVPSYVPIVKKHCDDSYTPQDKLWQQLRRGRYVEFNLVYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPPENSKEAEILEVLRHPKDWV 442
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. UniProt/SwissProt
Match: sp|P36551|HEM6_HUMAN (Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Homo sapiens OX=9606 GN=CPOX PE=1 SV=3)

HSP 1 Score: 395.201 bits (1014), Expect = 6.749e-133
Identity = 181/333 (54.35%), Postives = 247/333 (74.17%), Query Frame = 2 
Query:  125 DELIN-TTVWMSESVNEKSELLK-SDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDL-NEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            DEL +  + +M+  V +  EL +     + KME L L+ Q ++C+++ ++DG   F VD+WERK GGGG++CV+ DG VFEKAGV+IS +HG+L+++A  QM++R   L  ++ +  F A G+SSVIHP+NPH P  HFN+RYFE+E+ DG K WWFGGG DLTP +L +EDA+HFHRTLK ACD H    YP++K+WCD YFFIAHR ERRG+GGIFFDD +   +E  F+FVQ+ A A+ PSY+PLV++ C+  +T  ++ WQ +RRGRYVEFNL+YDRGTKFGL TP +RIESILMSLPL A+W Y H   ++ +++ +L VL+ PR+WV
Sbjct:  121 DELAHRCSSFMAPPVTDLGELRRRPGDMKTKMELLILETQAQVCQALAQVDGGANFSVDRWERKEGGGGISCVLQDGCVFEKAGVSISVVHGNLSEEAAKQMRSRGKVLKTKDGKLPFCAMGVSSVIHPKNPHAPTIHFNYRYFEVEEADGNKQWWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHGPDLYPKFKKWCDDYFFIAHRGERRGIGGIFFDDLDSPSKEEVFRFVQSCARAVVPSYIPLVKKHCDDSFTPQEKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPSENSKEAEILEVLRHPRDWV 453
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. UniProt/SwissProt
Match: sp|P36552|HEM6_MOUSE (Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial OS=Mus musculus OX=10090 GN=Cpox PE=1 SV=2)

HSP 1 Score: 394.43 bits (1012), Expect = 8.553e-133
Identity = 180/333 (54.05%), Postives = 245/333 (73.57%), Query Frame = 2 
Query:  125 DELIN-TTVWMSESVNEKSELLK-SDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDL-NEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            DEL    + +MS  V E  EL +  +  + KME + ++ Q ++CR++ ++DG   F VD+WERK GGGG+TCV+ DG VFEKAGV+IS +HG+L+++A  QM+ R   L  ++ +  F A G+SSVIHP+NP+ P  HFN+RYFE+E+ DG   WWFGGG DLTP +L +EDA+HFHRTLK ACD H    YP++K+WCD YFFI HR ERRG+GGIFFDD +   +E +F+FV+T A A+ PSY+P+V++ C+  YT  D+ WQ +RRGRYVEFNL+YDRGTKFGL TP +RIESILMSLPL A+W Y H   ++ +++ +L VL+ P++WV
Sbjct:  110 DELARRCSTFMSSPVTELRELRRRPEDMKTKMELMIMETQAQVCRALAQVDGVADFTVDRWERKEGGGGITCVLQDGRVFEKAGVSISVVHGNLSEEAANQMRGRGKTLKTKDSKLPFTAMGVSSVIHPKNPYAPTMHFNYRYFEVEEADGNTHWWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHGPDIYPKFKKWCDDYFFIVHRGERRGIGGIFFDDLDSPSKEEAFRFVKTCAEAVVPSYVPIVKKHCDDSYTPRDKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPPENSKEAEILEVLRHPKDWV 442
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. UniProt/SwissProt
Match: sp|Q9UTE2|HEM6_SCHPO (Probable oxygen-dependent coproporphyrinogen-III oxidase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=hem13 PE=3 SV=1)

HSP 1 Score: 349.747 bits (896), Expect = 3.802e-117
Identity = 164/302 (54.30%), Postives = 209/302 (69.21%), Query Frame = 2 
Query:  209 KMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEEL-EYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREW 1111
            +ME+L L VQ E+   +E +DG +KFF DKW +  GG G++CV+ DGNVFEK GVN S + G L + A+ +M+A    ++    E  FFA GIS VIHPRNP  P  H N+RYFEL   DGKK+WWFGGG+DLTP+ L EED  HFH+  K ACD HD +FYPR+K+W D YF I HR E RG+GGIFFDD  +   +  F FV+  AH   P+Y+P++E+  N  +T+DD+E+QLIRRG Y EFN++YDRGT FGL  PE R+ESILM+LPL+A W Y ++    ER  ALL V  TP EW
Sbjct:   12 QMEKLILDVQQEIVAGLEAVDG-QKFFQDKWTKGEGGYGISCVIQDGNVFEKGGVNTSIVQGKLNQDAVQRMRANHEGIDRTAKELPFFAAGISMVIHPRNPMAPTTHLNYRYFELVNSDGKKIWWFGGGADLTPSILFEEDGKHFHKLHKEACDRHDPTFYPRFKKWADEYFLIKHRKETRGIGGIFFDDLSEKDPQELFAFVKDCAHTFLPAYVPIMEKRKNMEFTEDDKEFQLIRRGYYAEFNVMYDRGTWFGLQAPEPRVESILMTLPLHASWRYKYE-PKQERHKALLKVTHTPIEW 311
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. TrEMBL
Match: A0A4E0R836 (Oxygen-dependent coproporphyrinogen-III oxidase OS=Fasciola hepatica OX=6192 GN=D915_004167 PE=4 SV=1)

HSP 1 Score: 448.743 bits (1153), Expect = 1.145e-152
Identity = 207/324 (63.89%), Postives = 254/324 (78.40%), Query Frame = 2 
Query:  149 WMSESVNEKSELLKS--DSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            WM+ S+     L K    SYRAKME LCLQ+QG+LCR MER+DGK KF VDKW+RKAGGGG+TCVM DG VFEKAGVNISAIHG+L+  A+ +M+AR S+++ + + +FFACGISSVIHPRNP+VP  HFNFRYFE++   G+K WW+GGGSDLTP +L EEDA HFH+ LK ACD H+ ++Y ++K+WCD YF++ HR E RG+GGIFFDD E    E +F+FV++ A AI P+Y+P+VE+     Y + +REWQL+RRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYA WVY +    D R   LL+VL  PREWV
Sbjct:   51 WMTTSITPWKVLEKELDTSYRAKMEALCLQLQGKLCREMERVDGKAKFLVDKWDRKAGGGGITCVMEDGAVFEKAGVNISAIHGTLSPAAVREMRARHSEIDVDKDCKFFACGISSVIHPRNPYVPTTHFNFRYFEVDLGQGRKCWWYGGGSDLTPFYLFEEDAKHFHQQLKAACDKHNPTYYGKFKKWCDEYFYLKHRGETRGIGGIFFDDLEGESHEKTFEFVRSCAEAIIPAYIPIVEKRHKMRYVNSEREWQLVRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYASWVYCYDTTKDPRNQQLLDVLVKPREWV 374
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. TrEMBL
Match: A0A1S8X3H3 (Coproporphyrinogen III oxidase (Fragment) OS=Opisthorchis viverrini OX=6198 GN=X801_02879 PE=4 SV=1)

HSP 1 Score: 446.432 bits (1147), Expect = 3.749e-152
Identity = 208/340 (61.18%), Postives = 262/340 (77.06%), Query Frame = 2 
Query:  101 IMNKIINYDELINTTVWMSESVNEKSELLK--SDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            I+N  ++   L N   WMS SV    EL+     S+RAK+E LC+Q+QG+LCR ME+IDG+ +F VDKW+RKAGGGG++CVM +G VFEKAGVNIS+I G+L++ A+ +M+ R  +LN + E  FFACGISSVIHP NP VP  HFNFRYFE+ + DG+K WW+GGGSDLTP +L EEDA HFH  LK ACD HD ++YPR+K+WCD YFF+ HR E RGVGGIFFDD E   Q+  F+FV++ A AI P+YLP+VER  +  Y D +REWQL+RRGRYVEFNL+YDRGTKFGLATPEAR+ESILMSLPL+A+WVY ++   D R  +L+ VL+ PREW+
Sbjct:    4 IVNASVDLRNL-NPQEWMSPSVTPSDELVNRLDSSFRAKIETLCMQLQGKLCREMEKIDGQARFRVDKWDRKAGGGGISCVMENGAVFEKAGVNISSITGTLSENAVKEMRVRHQELNVDNECNFFACGISSVIHPLNPFVPTTHFNFRYFEVIQSDGRKSWWYGGGSDLTPYYLFEEDARHFHEQLKVACDKHDPTYYPRFKKWCDEYFFLKHRGETRGVGGIFFDDLEGQSQQQVFEFVRSCAEAIIPAYLPIVERRKDTPYGDLEREWQLVRRGRYVEFNLIYDRGTKFGLATPEARVESILMSLPLHAQWVYCYEDSKDPRNQSLIEVLKNPREWL 342
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. TrEMBL
Match: A0A074Z571 (Uncharacterized protein OS=Opisthorchis viverrini OX=6198 GN=T265_14894 PE=4 SV=1)

HSP 1 Score: 446.047 bits (1146), Expect = 5.145e-152
Identity = 208/340 (61.18%), Postives = 262/340 (77.06%), Query Frame = 2 
Query:  101 IMNKIINYDELINTTVWMSESVNEKSELLK--SDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            I+N  ++   L N   WMS SV    EL+     S+RAK+E LC+Q+QG+LCR ME+IDG+ +F VDKW+RKAGGGG++CVM +G VFEKAGVNIS+I G+L++ A+ +M+ R  +LN + E  FFACGISSVIHP NP VP  HFNFRYFE+ + DG+K WW+GGGSDLTP +L EEDA HFH  LK ACD HD ++YPR+K+WCD YFF+ HR E RGVGGIFFDD E   Q+  F+FV++ A AI P+YLP+VER  +  Y D +REWQL+RRGRYVEFNL+YDRGTKFGLATPEAR+ESILMSLPL+A+WVY ++   D R  +L+ VL+ PREW+
Sbjct:    4 IVNASVDLRNL-NPQEWMSPSVTPSDELVNRLDSSFRAKIETLCMQLQGKLCREMEKIDGQARFRVDKWDRKAGGGGISCVMENGAVFEKAGVNISSITGTLSENAVKEMRVRHQELNVDNECNFFACGISSVIHPLNPFVPTTHFNFRYFEVIQSDGRKSWWYGGGSDLTPYYLFEEDARHFHEQLKLACDKHDPTYYPRFKKWCDEYFFLKHRGETRGVGGIFFDDLEGQSQQQVFEFVRSCAEAIIPAYLPIVERRKDTPYGDLEREWQLVRRGRYVEFNLIYDRGTKFGLATPEARVESILMSLPLHAQWVYCYEDSKDPRNQSLIEVLKNPREWL 342
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. TrEMBL
Match: A0A5J4NEY8 (Coproporphyrinogen III oxidase OS=Paragonimus westermani OX=34504 GN=DEA37_0010316 PE=4 SV=1)

HSP 1 Score: 446.047 bits (1146), Expect = 2.892e-151
Identity = 203/329 (61.70%), Postives = 259/329 (78.72%), Query Frame = 2 
Query:  134 INTTVWMSESVNEKSELLKS--DSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            I+ T WM+ S+   ++L K    SYRA+ME LC+Q+QG+LCR ME+IDG  KF VDKWERKAGGGG++CVM +G VFEKAGVNISAIHG+L+  A+ +M+AR  +++ + + RFFACGISSVIHP NP+VP  HFNFRYFE++  + +K WWFGGG+DLTP +L +EDA HFHR L+ AC+ H+ S+Y R+K+WCD YF++ HR E RG+GGIFFDD E    E +F F+++ A +I P+YLP+VE+  N  Y D +REWQL+RRGRYVEFNL+YDRGTKFGLATPEARIESILMSLPLYA+WVY +    D R   LL+VL+TPREW+
Sbjct:   62 IDPTEWMTSSITPYNQLSKDLDSSYRAQMETLCMQLQGKLCREMEKIDGCAKFRVDKWERKAGGGGISCVMENGAVFEKAGVNISAIHGTLSPAAVKEMRARHQEIDVDKDCRFFACGISSVIHPLNPYVPTTHFNFRYFEVDLGNNRKCWWFGGGADLTPYYLFDEDAKHFHRQLQLACNKHNPSYYNRFKKWCDEYFYLKHRGETRGIGGIFFDDLEGDSHEQTFAFIRSCAESIIPAYLPIVEKRMNMAYKDLEREWQLVRRGRYVEFNLIYDRGTKFGLATPEARIESILMSLPLYAQWVYCYDASKDPRNQHLLDVLKTPREWL 390
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. TrEMBL
Match: A0A4V3SE59 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_007003 PE=4 SV=1)

HSP 1 Score: 443.736 bits (1140), Expect = 3.433e-151
Identity = 208/340 (61.18%), Postives = 260/340 (76.47%), Query Frame = 2 
Query:  101 IMNKIINYDELINTTVWMSESVNEKSELLK--SDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            I+N  ++   L N   WMS SV    EL+     S+RAK+E LC+Q+QG+LCR ME+IDG+ +F VDKW+RKAGGGG++CVM +G VFEKAGVNIS+I G+L+  A+ +M+ R  +LN + E  FFACGISSVIHP NP VP  HFNFRYFE+ + DG+K WW+GGGSDLTP +L EEDA HFH  LK ACD HD ++YPR+K+WCD YFF+ HR E RGVGGIFFDD E   Q+  F+FV++ A AI P+YLP+VER  +  Y D +REWQL+RRGRYVEFNL+YDRGTKFGLATPEAR+ESILMSLPL+A+WVY ++   D R   L+ VL+ PREW+
Sbjct:    4 IVNASVDLRNL-NPQEWMSPSVTPSDELVNELDSSFRAKIETLCMQLQGKLCREMEKIDGQARFRVDKWDRKAGGGGISCVMENGAVFEKAGVNISSITGTLSLNAVKEMRVRHQELNVDNECNFFACGISSVIHPLNPFVPTTHFNFRYFEVIQSDGRKSWWYGGGSDLTPYYLFEEDARHFHEQLKVACDKHDPTYYPRFKKWCDEYFFLKHRGETRGVGGIFFDDLEGQSQQQVFEFVRSCAEAIIPAYLPIVERRKDTPYGDLEREWQLVRRGRYVEFNLIYDRGTKFGLATPEARVESILMSLPLHAQWVYCYEDSKDPRNQNLIEVLKNPREWL 342
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Cavefish
Match: cpox (coproporphyrinogen oxidase [Source:NCBI gene;Acc:103037108])

HSP 1 Score: 375.941 bits (964), Expect = 1.128e-126
Identity = 166/310 (53.55%), Postives = 225/310 (72.58%), Query Frame = 2 
Query:  188 KSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDL-NEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            + +   ++ME L +Q Q E CR++E +DG  KF VD+W R  GGGG++CVM D NVFEKAGVN+S +HG LT++A  QM++R   L  ++ +  F A G+SSVIHP+NPH+P  HFN+RYFE+E+ DG K WWFGGG+DLTP ++ +ED   FH  L+ ACD H   +YP +K+WCDRYF+I HR E RG+GGIFFDD +   QE  F+FV++ A  + P YLP+V +     +T ++++WQ +RRGRYVEFNLVYDRG KFGLATP +RIESILMSLPL A+W Y H+     R++ ++ VL+ P+EW+
Sbjct:  117 RKEEISSRMEMLIMQTQAEFCRALEEVDGG-KFKVDRWSRAEGGGGISCVMQDSNVFEKAGVNVSVVHGYLTEEAAKQMRSRGKVLKGKDGKLPFIAMGVSSVIHPKNPHIPTVHFNYRYFEIEEEDGSKQWWFGGGTDLTPVYIDKEDGALFHNVLREACDKHHPKYYPDFKKWCDRYFYIRHRGETRGIGGIFFDDLDSPSQEEVFKFVKSCAKTVVPCYLPIVHKHLKDSFTQEEKDWQQVRRGRYVEFNLVYDRGVKFGLATPGSRIESILMSLPLTARWEYMHEPSKGTREAEMIEVLRNPKEWI 425
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Yeast
Match: HEM13 (Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid [Source:SGD;Acc:S000002451])

HSP 1 Score: 322.398 bits (825), Expect = 4.568e-108
Identity = 155/316 (49.05%), Postives = 205/316 (64.87%), Query Frame = 2 
Query:  203 RAKMERLCLQVQGELCRSMERIDGKEKFFVDKWER-KAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELE----------YRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDG-KKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            R +ME L  + Q E+ + +E ID   KF  D W R   GGGG + V+ DG  FEK GVN+S ++G L+  A+  MKA   +L    +           +FFACG+S VIHP NPH P  H N+RYFE    DG  + WWFGGG+DLTP++L EED   FH+  K+A D HD + YPR+K+WCD YF+I HR E RG+GGIFFDD+++   +   + V+    A  PSYL +V+R  +  YT ++++WQ IRRGRYVEFNL+YDRGT+FGL TP +R+ESILMSLP +A W+Y+H      R++ LL V   PREWV
Sbjct:   13 RQQMEALIRRKQAEITQGLESID-TVKFHADTWTRGNDGGGGTSMVIQDGTTFEKGGVNVSVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAPTTHLNYRYFETWNQDGTPQTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKKWCDEYFYITHRKETRGIGGIFFDDYDERDPQEILKMVEDCFDAFLPSYLTIVKRRKDMPYTKEEQQWQAIRRGRYVEFNLIYDRGTQFGLRTPGSRVESILMSLPEHASWLYNHHPAPGSREAKLLEVTTKPREWV 327
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Nematostella
Match: EDO41336 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4S5])

HSP 1 Score: 399.053 bits (1024), Expect = 1.102e-137
Identity = 188/322 (58.39%), Postives = 239/322 (74.22%), Query Frame = 2 
Query:  152 MSESVNEKSELLKS-DSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            M + + +   L K+ DS R KME + L+ QGE+CR +  +DGK KF VD+WER+ GGGG+TCV+ DG VFEKAGVN+S ++G+L  +A  QMK+R      E +  FFACGISSVIHPRNP+VP  HFN+RYFE+   DG+K  WFGGG+DLTP +L E+D +HFH  LK  CD HD S+Y R+K WCD+YFFI HR E RGVGGIFFDD ED  +E  F F+++ A A+ P+Y P+VE+  N  Y+++DR+WQL+RRGRYVEFNLVYDRGTKFGL TP +RIESILMSLPL A+W Y H  D + R+  +L VL+ PREW+
Sbjct:    1 MGKPLTDIKTLEKNKDSMRTKMEVMILKAQGEICRKLSDLDGK-KFQVDRWERQQGGGGMTCVIQDGKVFEKAGVNVSVVYGTLAAKAAQQMKSRGKGFKGE-DLPFFACGISSVIHPRNPYVPTVHFNYRYFEVTDIDGQKHAWFGGGTDLTPYYLNEQDVMHFHGVLKRVCDKHDASYYQRFKSWCDKYFFIPHRGECRGVGGIFFDDLEDPTEEKLFNFLESCAEAVIPAYAPIVEKHMNDPYSEEDRKWQLLRRGRYVEFNLVYDRGTKFGLYTPGSRIESILMSLPLEARWEYMHVPDKNSREEKMLEVLRNPREWI 320
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Nematostella
Match: EDO27968 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T7T0])

HSP 1 Score: 253.832 bits (647), Expect = 2.287e-81
Identity = 124/290 (42.76%), Postives = 177/290 (61.03%), Query Frame = 2 
Query:  212 MERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSAL 1081
            +++  L +Q ++C+++   + K+ F  D+W+RK GGGG + V+ DG VFEKAGVN S + G     +    +  L+         F A G+S V+HPRNP+VP  HFN R F   K     +WWFGGG DLTP +  EED +HFH+  KNAC       YP+YK+W D YF++ HR E RGVGG+FFDD  + G +  F F++++      +Y P++ +  + +Y + + ++Q  RRGRYVEFNLV+DRGT FGL T   R ESILMSLP++  W Y  Q +    ++ L
Sbjct:    9 VKKYLLSLQDKICKTLVNEESKDNFCQDEWQRKEGGGGRSRVIQDGAVFEKAGVNFSHVFGDGLPASATATRPALAGRG------FEAMGVSCVVHPRNPYVPTSHFNVRLFIANKEGEDPIWWFGGGFDLTPYYPFEEDCVHFHQQAKNACSPFGHELYPKYKKWADEYFYLKHRQEARGVGGLFFDDLNEGGFDHCFNFMRSVGDHFMSAYQPIIAKRKDHVYGERELDFQYYRRGRYVEFNLVFDRGTVFGLHT-GGRTESILMSLPMHVTWRYDWQPEPGTAEARL 291
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Medaka
Match: cpox (coproporphyrinogen oxidase [Source:NCBI gene;Acc:101156396])

HSP 1 Score: 392.889 bits (1008), Expect = 7.603e-133
Identity = 181/324 (55.86%), Postives = 238/324 (73.46%), Query Frame = 2 
Query:  149 WMSESVNEKSELL-KSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDL-NEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYLPLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIESILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV 1114
            +MS  V + S L  + +  R KME L ++ Q E C+++E +DG   F VD+WERK GGGG++CVM DG VFEKAGVN+S + G LT++A  QM++R   L  ++ +  F A G+SSVIHP+NPH+P  HFN+RYFE+E+ DG K WWFGGG+DLTP ++ +EDA HFH TLK ACD H   +YP +K+WCDRYFF+ HR E RG+GGIFFDD +  GQE +F FV++ A  + P YLP+V +  N  +TD++++WQ IRRGRYVEFNLVYDRG KFGLATP +RIESILMSLPL A+W Y  + D   R++ +L VL+ P+EWV
Sbjct:  136 FMSAPVTDISVLQSRKEEMRTKMELLIMETQAEFCKALEEVDGG-TFKVDRWERKEGGGGISCVMQDGKVFEKAGVNVSVVSGYLTEEAAKQMRSRGKVLKGKDGKLPFSAMGVSSVIHPKNPHIPTVHFNYRYFEIEEEDGSKQWWFGGGTDLTPVYIDKEDAFHFHNTLKEACDKHHPQYYPDFKKWCDRYFFVRHRGETRGIGGIFFDDLDSPGQEEAFNFVKSCARTVVPCYLPIVYKHLNDSFTDEEKDWQQIRRGRYVEFNLVYDRGVKFGLATPGSRIESILMSLPLTARWEYMQEPDKGSREAEMLEVLRNPKEWV 458
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Planmine SMEST
Match: SMESG000039696.1 (SMESG000039696.1)

HSP 1 Score: 496.508 bits (1277), Expect = 1.080e-176
Identity = 238/253 (94.07%), Postives = 240/253 (94.86%), Query Frame = 2 
Query:  104 MNKIINYDELINTTVWMSESVNEKSELLKSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQT-LAHAIEPSYLPL 859
            MNKIINYDELINTTVWMSESVNEKSELLKSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHD SFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEA F   +  L  +  P YL L
Sbjct:    1 MNKIINYDELINTTVWMSESVNEKSELLKSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDPSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEALFNLSKPLLTQSNPPIYLSL 253

HSP 2 Score: 76.2554 bits (186), Expect = 3.108e-15
Identity = 38/50 (76.00%), Postives = 41/50 (82.00%), Query Frame = 3 
Query:  762 GYFSMTMKTMVKKLLFNLSKPLLTQSNPPIYLSLSVPVISYIPTMIESGS 911
            G F    +   ++ LFNLSKPLLTQSNPPIYLSLSVPVISYIPTMIESGS
Sbjct:  220 GIFFDDHEDHGQEALFNLSKPLLTQSNPPIYLSLSVPVISYIPTMIESGS 269
[Close]
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Planmine SMEST
Match: SMESG000039696.1 (SMESG000039696.1)

HSP 1 Score: 462.611 bits (1189), Expect = 1.972e-163
Identity = 222/237 (93.67%), Postives = 224/237 (94.51%), Query Frame = 2 
Query:  152 MSESVNEKSELLKSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQT-LAHAIEPSYLPL 859
            MSESVNEKSELLKSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHD SFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEA F   +  L  +  P YL L
Sbjct:    1 MSESVNEKSELLKSDSYRAKMERLCLQVQGELCRSMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLTKQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFELEKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDPSFYPRYKEWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEALFNLSKPLLTQSNPPIYLSL 237

HSP 2 Score: 76.2554 bits (186), Expect = 2.013e-15
Identity = 38/50 (76.00%), Postives = 41/50 (82.00%), Query Frame = 3 
Query:  762 GYFSMTMKTMVKKLLFNLSKPLLTQSNPPIYLSLSVPVISYIPTMIESGS 911
            G F    +   ++ LFNLSKPLLTQSNPPIYLSLSVPVISYIPTMIESGS
Sbjct:  204 GIFFDDHEDHGQEALFNLSKPLLTQSNPPIYLSLSVPVISYIPTMIESGS 253
The following BLAST results are available for this feature:
BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CPOX1.405e-13354.35coproporphyrinogen oxidase [Source:HGNC Symbol;Acc... [more]
AC021660.32.724e-1968.52novel transcript[more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Coprox2.805e-14056.53gene:FBgn0021944 transcript:FBtr0079352[more]
Coprox2.805e-14056.53gene:FBgn0021944 transcript:FBtr0346584[more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cpox1.873e-12552.90coproporphyrinogen oxidase [Source:ZFIN;Acc:ZDB-GE... [more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mtfr1l4.314e-13356.49mitochondrial fission regulator 1-like [Source:Xen... [more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Cpox1.223e-13354.05coproporphyrinogen oxidase [Source:MGI Symbol;Acc:... [more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9V3D2|HEM6_DROME2.811e-13956.53Oxygen-dependent coproporphyrinogen-III oxidase OS... [more]
sp|Q3B7D0|HEM6_RAT4.860e-13655.86Oxygen-dependent coproporphyrinogen-III oxidase, m... [more]
sp|P36551|HEM6_HUMAN6.749e-13354.35Oxygen-dependent coproporphyrinogen-III oxidase, m... [more]
sp|P36552|HEM6_MOUSE8.553e-13354.05Oxygen-dependent coproporphyrinogen-III oxidase, m... [more]
sp|Q9UTE2|HEM6_SCHPO3.802e-11754.30Probable oxygen-dependent coproporphyrinogen-III o... [more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0R8361.145e-15263.89Oxygen-dependent coproporphyrinogen-III oxidase OS... [more]
A0A1S8X3H33.749e-15261.18Coproporphyrinogen III oxidase (Fragment) OS=Opist... [more]
A0A074Z5715.145e-15261.18Uncharacterized protein OS=Opisthorchis viverrini ... [more]
A0A5J4NEY82.892e-15161.70Coproporphyrinogen III oxidase OS=Paragonimus west... [more]
A0A4V3SE593.433e-15161.18Uncharacterized protein OS=Opisthorchis felineus O... [more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cpox1.128e-12653.55coproporphyrinogen oxidase [Source:NCBI gene;Acc:1... [more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
HEM134.568e-10849.05Coproporphyrinogen III oxidase; oxygen-requiring e... [more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO413361.102e-13758.39Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO279682.287e-8142.76Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cpox7.603e-13355.86coproporphyrinogen oxidase [Source:NCBI gene;Acc:1... [more]
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BLAST of Oxygen-dependent coproporphyrinogen-III oxidase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000039696.11.080e-17694.07SMESG000039696.1[more]
SMESG000039696.11.972e-16393.67SMESG000039696.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30029098 ID=SMED30029098|Name=Oxygen-dependent coproporphyrinogen-III oxidase|organism=Schmidtea mediterranea sexual|type=transcript|length=1454bp
ATTTATTCAAATCAGATTTTGCTTAAAATTATTTCATTAAATTCTAATTT
TATAAATAACATTTTGATTAACATCAATTTTTCGCGTCTTCAAAATTTTA
ATAATGAATAAAATTATTAATTATGACGAATTAATTAATACGACAGTGTG
GATGAGTGAGTCGGTGAATGAGAAATCTGAGTTATTGAAAAGTGATAGTT
ACCGTGCGAAAATGGAAAGACTTTGTTTGCAAGTTCAAGGTGAATTGTGT
AGAAGTATGGAAAGAATAGATGGAAAAGAAAAATTTTTTGTCGATAAATG
GGAGAGAAAGGCTGGCGGCGGAGGTGTTACATGCGTAATGTCTGATGGAA
ATGTCTTTGAAAAAGCTGGTGTTAATATTTCAGCTATTCATGGATCTCTA
ACCAAACAAGCTATTATTCAGATGAAAGCGCGATTGAGTGATTTAAATGA
AGAATTAGAATACCGATTTTTTGCTTGCGGAATAAGTTCAGTTATCCATC
CTAGGAATCCACACGTTCCAGCTTGTCACTTCAATTTCCGTTATTTTGAA
TTAGAAAAACCAGACGGGAAAAAGGTTTGGTGGTTTGGCGGTGGCTCAGA
TTTGACACCGAATTTTTTGGTTGAAGAAGATGCCATACATTTTCATCGTA
CATTGAAAAATGCTTGTGATTTACATGATCTCTCTTTCTATCCTCGATAC
AAAGAATGGTGTGATCGATATTTCTTTATAGCTCATCGCAATGAACGTCG
AGGAGTTGGAGGGATATTTTTCGATGACCATGAAGACCATGGTCAAGAAG
CTTCTTTTCAATTTGTCCAAACCCTTGCTCACGCAATCGAACCCTCCTAT
TTACCTCTCGTTGAGCGTGCCTGTAATAAGTTATATACCGACGATGATCG
AGAGTGGCAGCTGATACGTCGCGGTAGATACGTTGAATTTAACCTGGTCT
ATGACCGAGGCACCAAATTCGGTCTGGCTACTCCTGAAGCCCGCATAGAG
AGCATTCTAATGTCTCTGCCATTATATGCGAAATGGGTTTACTCTCACCA
GGTGGATGATGATGAAAGAAAAAGTGCCTTGCTAAATGTTTTGCAAACCC
CTCGTGAATGGGTCTGATAGTGATTATATTAGGTCAAGTCGTATCCGAGT
GCATTATTCTGTTTTCATAATAATAATAAAATTAATTAGTTTAAATGCCT
TGATTTTTTGTTTAAATATTGATGTAATAACTGGTGTAGTATTGATAATT
TATTGGATTTGTGATTGCCGACCGGTACATTCAATGACTGACTGACTGAA
TTGCCGCTGTCCTGCATGCGGTCCGGTCCAGAATTTTGGCAGGCAGCCAA
TTATCGGCTTGTCTCATCAATTATTATTGGCTGACGAAATCTCGGTGACT
AATAATCTGCGTGACGCTTACGTTTTATCTGTAAAATATAAGCAGCGGAA
TATG
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protein sequence of SMED30029098-orf-1

>SMED30029098-orf-1 ID=SMED30029098-orf-1|Name=SMED30029098-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=338bp
MNKIINYDELINTTVWMSESVNEKSELLKSDSYRAKMERLCLQVQGELCR
SMERIDGKEKFFVDKWERKAGGGGVTCVMSDGNVFEKAGVNISAIHGSLT
KQAIIQMKARLSDLNEELEYRFFACGISSVIHPRNPHVPACHFNFRYFEL
EKPDGKKVWWFGGGSDLTPNFLVEEDAIHFHRTLKNACDLHDLSFYPRYK
EWCDRYFFIAHRNERRGVGGIFFDDHEDHGQEASFQFVQTLAHAIEPSYL
PLVERACNKLYTDDDREWQLIRRGRYVEFNLVYDRGTKFGLATPEARIES
ILMSLPLYAKWVYSHQVDDDERKSALLNVLQTPREWV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0002142parenchyma
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR001260Coprogen_oxidase_aer
IPR018375Coprogen_oxidase_CS
Vocabulary: biological process
TermDefinition
GO:0006779porphyrin-containing compound biosynthetic process
GO:0055114oxidation-reduction process
GO:0006782protoporphyrinogen IX biosynthetic process
GO:0006783heme biosynthetic process
Vocabulary: molecular function
TermDefinition
GO:0004109coproporphyrinogen oxidase activity
GO:0016491oxidoreductase activity
GO:0042803protein homodimerization activity
Vocabulary: cellular component
TermDefinition
GO:0005739mitochondrion