Protein-tyrosine-phosphatase
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30029055 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 7
Homology
BLAST of Protein-tyrosine-phosphatase vs. TrEMBL
Match: A0A177QAL3 (TYR_PHOSPHATASE_2 domain-containing protein OS=bacterium SCGC AG-212-C10 OX=1799370 GN=AYO38_00120 PE=4 SV=1) HSP 1 Score: 81.2629 bits (199), Expect = 5.838e-14 Identity = 53/180 (29.44%), Postives = 84/180 (46.67%), Query Frame = 2 Query: 185 NFRPIIPSDRFHCSSM----IYRSNSIDDGKLDSVQWLFNEVKIKLILDLRNEIEFHPNSQLDQCYQLI----DFDEINEFQQNLDKYDSIKGYRCHVGFSYGNFNSQFGTVEDFYLHLIDNNKHVMKSIFSFMGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDA 700 NFR + P ++ IYRS +++ WL N++ I+ ++DLR+ EF + Q +L+ F E Q + + + + YGN G + YLH + H F + ++ +P+LI C+ GKDRTGVV M++D++G I DEY SDA Sbjct: 12 NFRAVAPYPLRGGGTIRANSIYRSGALELMTEADYAWLANDIGIRRVMDLRHPDEFGEGVK-HQLAELVCPLSIFPETGTQQSIIAELNGL----------YGN-----GPSPERYLHYLQAGSHRFVESFQVLAEAETYPVLIHCTAGKDRTGVVVGMLMDILGASDEDIADEYGLSDA 175
BLAST of Protein-tyrosine-phosphatase vs. TrEMBL
Match: A0A417C6L4 (Protein-tyrosine-phosphatase OS=Erysipelatoclostridium sp. AM42-17 OX=2293102 GN=DW911_10430 PE=4 SV=1) HSP 1 Score: 80.8777 bits (198), Expect = 5.935e-14 Identity = 69/200 (34.50%), Postives = 106/200 (53.00%), Query Frame = 2 Query: 302 IKLILDLRNEIEFHPNSQLDQCYQLIDFDEINEFQ-QNLDK-YDSIKGYRCHVGFSYGNFNSQFGTVEDFYLHLIDNNKHVMKSIFSFMGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQIVKEKNINTEFAKCPIGAIKQFVIXXXXXXXXXXXXXXECGLTELDIEKIRSNL 895 I+ ++DLR+ E + YQ I++ I+ Q QN D+IK Y+ GF Y+ +I+ NK+ MK IF I+ CS GKDRTGVVSA++LDL GC + I+ +Y +S KP+ ++L ++KE+ + +F + +F+ YL+ YG K YL +CGL E I++I+ NL Sbjct: 60 IRTVVDLRSPFEVEQLPHPLKEYQDIEYYHIDLLQSQNFSLIADNIKEYQDLSGF---------------YIFMIEANKNQMKKIFEIFYEHPYDAIMFNCSAGKDRTGVVSALLLDLAGCHEYDIVKDYSESFENNKPILDQLKGMIKEE--DEKFLGSDPRIMMKFLAYLRETYGSAKEYLLQCGLDEEQIQEIKENL 242
BLAST of Protein-tyrosine-phosphatase vs. TrEMBL
Match: A0A415RI38 (Protein-tyrosine-phosphatase OS=Coprobacillus sp. AF33-1AC OX=2292032 GN=DWZ53_10495 PE=4 SV=1) HSP 1 Score: 80.8777 bits (198), Expect = 5.935e-14 Identity = 69/200 (34.50%), Postives = 106/200 (53.00%), Query Frame = 2 Query: 302 IKLILDLRNEIEFHPNSQLDQCYQLIDFDEINEFQ-QNLDK-YDSIKGYRCHVGFSYGNFNSQFGTVEDFYLHLIDNNKHVMKSIFSFMGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQIVKEKNINTEFAKCPIGAIKQFVIXXXXXXXXXXXXXXECGLTELDIEKIRSNL 895 I+ ++DLR+ E + YQ I++ I+ Q QN D+IK Y+ GF Y+ +I+ NK+ MK IF I+ CS GKDRTGVVSA++LDL GC + I+ +Y +S KP+ ++L ++KE+ + +F + +F+ YL+ YG K YL +CGL E I++I+ NL Sbjct: 60 IRTVVDLRSPFEVEQLPHPLKEYQDIEYYHIDLLQSQNFSLIADNIKEYQDLSGF---------------YIFMIEANKNQMKKIFEIFYEHPYDAIMFNCSAGKDRTGVVSALLLDLAGCHEYDIVKDYSESFENNKPILDQLKGMIKEE--DEKFLGSDPRIMMKFLAYLRETYGSAKEYLLQCGLDEEQIQEIKENL 242
BLAST of Protein-tyrosine-phosphatase vs. TrEMBL
Match: A0A507FTF4 (TYR_PHOSPHATASE_2 domain-containing protein OS=Chytriomyces confervae OX=246404 GN=CcCBS67573_g00324 PE=4 SV=1) HSP 1 Score: 80.1073 bits (196), Expect = 1.689e-13 Identity = 55/147 (37.41%), Postives = 90/147 (61.22%), Query Frame = 2 Query: 467 GNFNSQFGTVEDFYLHLIDNNKHVMKSIFSFMGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQIVKEKNINT-EFAKCPIGAIKQFVIXXXXXXXXXXXXXXECGLTELDIEKIRSNLLNV 904 G+F ++ G + FY+ L+DN+ IF F+ +FP+LI CS GKDRTG++SA++ L+G + I+ +YL S+ L+ VQ L + V + + EFA C A+ F+ +L T+YGG YL+ G++ + + +R+NLL+V Sbjct: 115 GSFLNKPGGLTRFYIVLLDNHGDEFNRIFRFLTEKSHFPVLIHCSAGKDRTGILSALIHRLMGTPDADILKDYLLSNKGLESVQTLLEKEVDKMGMCVNEFAGCKEEAMIGFLDHLDTRYGGVHSYLESIGVSRAEQDLVRTNLLDV 261
BLAST of Protein-tyrosine-phosphatase vs. TrEMBL
Match: V9L682 (TYR_PHOSPHATASE_2 domain-containing protein OS=Callorhinchus milii OX=7868 GN=LOC103182731 PE=2 SV=1) HSP 1 Score: 76.6406 bits (187), Expect = 3.918e-12 Identity = 64/242 (26.45%), Postives = 103/242 (42.56%), Query Frame = 2 Query: 167 MNLPPCNFRPIIPSDRFHCSSM--IYRSNSIDDGKLDSVQWLFNEVKIKLILDLRNEIEFHPNSQ-----LDQCYQLIDFDEINEFQQNLDKYDSIK-------GYRCHVGFSYGNFNSQFGT--------------------------------------VEDFYLHLIDNNKHVMKSIFSFMGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQI 736 M + P N IP+ R CS IYRS S D + V+ L + I+LI+DLR+ E +S +D Y+ + E E + K + K G RC + F+ + ++ T V+ Y L+D ++ V+ +I + +N P LI C+ GKDRTGV +A++ VG + II++Y S +KP+ E+L+ + Sbjct: 11 MAIQPQN----IPNLRQLCSGFANIYRSASPDHASEEEVRVLKELLGIRLIIDLRSSEELQDSSHGGRKPIDISYERLKVTE-EEMEDTKRKGTTGKLLSGEAQGVRCVLSFATKKYKARLLTTMSACQKVLLMFMALIDRVFHTWLSQRYLTTRVLNPRGVKQQYTDLVDTSQTVIFTILKLLSEPRNVPALIHCTAGKDRTGVTAALIQLAVGWPKKNIIEDYTASTQGIKPIYEKLHTL 247
BLAST of Protein-tyrosine-phosphatase vs. Planmine SMEST
Match: SMESG000055801.1 (SMESG000055801.1) HSP 1 Score: 481.1 bits (1237), Expect = 3.455e-173 Identity = 250/252 (99.21%), Postives = 251/252 (99.60%), Query Frame = 2 Query: 167 MNLPPCNFRPIIPSDRFHCSSMIYRSNSIDDGKLDSVQWLFNEVKIKLILDLRNEIEFHPNSQLDQCYQLIDFDEINEFQQNLDKYDSIKGYRCHVGFSYGNFNSQFGTVEDFYLHLIDNNKHVMKSIFSFMGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQIVKEKNINTEFAKCPIGAIKQFVIXXXXXXXXXXXXXXECGLTELDIEKIRSNLLNVTETNRD 922 MNLPPCNFRPIIPSDRFHCSSMIYRSNSIDDGKLDSVQWLFNEVKIKLILDLRNEIEFHPNSQLDQCYQLIDFDEINEFQQNLDKYDSIKGYRCHVGFSYGNFNSQFGTVEDFYLHLIDNNKHVMKSIFSFMGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQIVKEKNIN EFAKCPIGAI+QFVIYLKTKYGGTKGYLKECGLTELDIEKIRSNLLNVTETNRD Sbjct: 1 MNLPPCNFRPIIPSDRFHCSSMIYRSNSIDDGKLDSVQWLFNEVKIKLILDLRNEIEFHPNSQLDQCYQLIDFDEINEFQQNLDKYDSIKGYRCHVGFSYGNFNSQFGTVEDFYLHLIDNNKHVMKSIFSFMGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQIVKEKNINPEFAKCPIGAIQQFVIYLKTKYGGTKGYLKECGLTELDIEKIRSNLLNVTETNRD 252
BLAST of Protein-tyrosine-phosphatase vs. Planmine SMEST
Match: SMESG000030078.1 (SMESG000030078.1) HSP 1 Score: 139.043 bits (349), Expect = 1.131e-38 Identity = 93/283 (32.86%), Postives = 140/283 (49.47%), Query Frame = 2 Query: 167 MNLPPCNFRPIIPSDRFHCSSMIYRSNSIDDGKLDSVQWLFNEVKIKLILDLRNEIEFHPNSQLDQCYQLIDFDEINEFQQNLDKYDSIKGYRCHVGF-----------------------------------SYGNFNSQ----FGTVEDFYLHLIDNNKHVMKSIFSFMGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQIVKEKNINTEFAKCPIGAIKQFVIXXXXXXXXXXXXXXECGLTELDIEKIRSNLL 898 M LPPCNFRP+ R + +YRSN+IDDG + S +WL + I +DLR EFHP S+L D+ + + + G R H+GF +Y + Q ++ +FY L+D+ + V K IF+ M + NFP++I CS+GKDRTG+V A++L LVG D II EY KS+ L +++ + + K E+ P A+ + +LK KYG + YLK CG+ E IE+I++N++ Sbjct: 1 MELPPCNFRPVFSIHRASAGTNLYRSNAIDDGTVKSAKWLRETIGINSYVDLREGNEFHPMSKLG------DYFIQTKLNKPIKNPPGNFGRRYHMGFITVSYHWNLLIHKLKFNQIFVLIFLLIQHLIYRDYAYQKYGGQCYLSTLSLGEFYASLLDDCQKVFKQIFTTMTDPDNFPMIICCSFGKDRTGIVVALLLKLVGWDDEDIIKEYTKSEGNLDSLKDEIRSFFEFKGAGEEYCHAPRSAMVTMLAHLKEKYGTVENYLKSCGINEGQIEQIKTNIM 277
BLAST of Protein-tyrosine-phosphatase vs. Planmine SMEST
Match: SMESG000055800.1 (SMESG000055800.1) HSP 1 Score: 92.4337 bits (228), Expect = 5.764e-23 Identity = 57/114 (50.00%), Postives = 80/114 (70.18%), Query Frame = 2 Query: 560 MGNSKNFPILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQIVKEKNINTEFAKCPIGAIKQFVIXXXXXXXXXXXXXXECGLTELDIEKIRSNLLN 901 M + NFP++I C+YGKDRTGVV+A+ ++L GC II EY +S LLKP+QE+LN + I EF + A++ F+ YLK KYGG++GYLK CG+T IEKI++N++N Sbjct: 1 MADESNFPMIIACNYGKDRTGVVAAIAMELTGCSDQLIISEYSQSQNLLKPMQEKLNSEMNFYQIRQEFIQSSPKAMEMFLHYLKNKYGGSEGYLKFCGVTNEQIEKIKNNIMN 114
BLAST of Protein-tyrosine-phosphatase vs. Planmine SMEST
Match: SMESG000055800.1 (SMESG000055800.1) HSP 1 Score: 82.4185 bits (202), Expect = 2.627e-19 Identity = 53/106 (50.00%), Postives = 75/106 (70.75%), Query Frame = 2 Query: 584 ILITCSYGKDRTGVVSAMVLDLVGCDQSTIIDEYLKSDALLKPVQERLNQIVKEKNINTEFAKCPIGAIKQFVIXXXXXXXXXXXXXXECGLTELDIEKIRSNLLN 901 ++I C+YGKDRTGVV+A+ ++L GC II EY +S LLKP+QE+LN + I EF + A++ F+ YLK KYGG++GYLK CG+T IEKI++N++N Sbjct: 1 MIIACNYGKDRTGVVAAIAMELTGCSDQLIISEYSQSQNLLKPMQEKLNSEMNFYQIRQEFIQSSPKAMEMFLHYLKNKYGGSEGYLKFCGVTNEQIEKIKNNIMN 106 The following BLAST results are available for this feature:
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Protein-tyrosine-phosphatase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 4
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30029055 ID=SMED30029055|Name=Protein-tyrosine-phosphatase|organism=Schmidtea mediterranea sexual|type=transcript|length=1016bpback to top protein sequence of SMED30029055-orf-1 >SMED30029055-orf-1 ID=SMED30029055-orf-1|Name=SMED30029055-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=253bp MNLPPCNFRPIIPSDRFHCSSMIYRSNSIDDGKLDSVQWLFNEVKIKLILback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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