Protein disulfide-isomerase A6
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30028938 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 31Note: Hover over icons to view figure legend
Homology
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Human
Match: PDIA6 (protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168]) HSP 1 Score: 471.47 bits (1212), Expect = 4.541e-163 Identity = 249/435 (57.24%), Postives = 309/435 (71.03%), Query Frame = 3
Query: 120 LSIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
L +V F LA N + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAATALK VVKVGAVD DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ S SS DV+ELTD +FD+ VL SE+ W+VEF+APWCGHCKNL+P W AASE++ GKVKL A+DATV+ ASRYG++G+PTIK F G DYDGGR+ SDIV A D + P PE+ EI+N++I K CE+HQLCVVAVLP+ILD + RN Y+ L DKYK WGWLWTEA ELE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G PTI EPWDG+DGE+P E++IDLS++ +++
Sbjct: 3 LGLVSCTFFLA-VNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKK--DVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESP---VDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDD 431
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Human
Match: PDIA6 (protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168]) HSP 1 Score: 471.085 bits (1211), Expect = 6.540e-163 Identity = 249/435 (57.24%), Postives = 309/435 (71.03%), Query Frame = 3
Query: 120 LSIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
L +V F LA N + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAATALK VVKVGAVD DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ S SS DV+ELTD +FD+ VL SE+ W+VEF+APWCGHCKNL+P W AASE++ GKVKL A+DATV+ ASRYG++G+PTIK F G DYDGGR+ SDIV A D + P PE+ EI+N++I K CE+HQLCVVAVLP+ILD + RN Y+ L DKYK WGWLWTEA ELE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G PTI EPWDG+DGE+P E++IDLS++ +++
Sbjct: 6 LGLVSCTFFLA-VNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKK--DVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESP---VDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDD 434
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Human
Match: PDIA6 (protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168]) HSP 1 Score: 470.7 bits (1210), Expect = 1.324e-162 Identity = 245/432 (56.71%), Postives = 306/432 (70.83%), Query Frame = 3
Query: 129 VLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
++ C N + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAATALK VVKVGAVD DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ S SS DV+ELTD +FD+ VL SE+ W+VEF+APWCGHCKNL+P W AASE++ GKVKL A+DATV+ ASRYG++G+PTIK F G DYDGGR+ SDIV A D + P PE+ EI+N++I K CE+HQLCVVAVLP+ILD + RN Y+ L DKYK WGWLWTEA ELE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G PTI EPWDG+DGE+P E++IDLS++ +++
Sbjct: 13 LVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKK--DVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESP---VDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDD 439
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Human
Match: PDIA6 (protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168]) HSP 1 Score: 471.855 bits (1213), Expect = 1.731e-162 Identity = 246/433 (56.81%), Postives = 309/433 (71.36%), Query Frame = 3
Query: 129 VLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQ-DYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
++ C N + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAATALK VVKVGAVD DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ S SS DV+ELTD +FD+ VL SE+ W+VEF+APWCGHCKNL+P W AASE++ GKVKL A+DATV+ ASRYG++G+PTIK F + G+S DYDGGR+ SDIV A D + P PE+ EI+N++I K CE+HQLCVVAVLP+ILD + RN Y+ L DKYK WGWLWTEA ELE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G PTI EPWDG+DGE+P E++IDLS++ +++
Sbjct: 56 LVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKK--DVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIF----QKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDD 482
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Human
Match: PDIA6 (protein disulfide isomerase family A member 6 [Source:HGNC Symbol;Acc:HGNC:30168]) HSP 1 Score: 469.929 bits (1208), Expect = 1.358e-161 Identity = 246/433 (56.81%), Postives = 309/433 (71.36%), Query Frame = 3
Query: 129 VLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQ-DYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
++ C N + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAATALK VVKVGAVD DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ S SS DV+ELTD +FD+ VL SE+ W+VEF+APWCGHCKNL+P W AASE++ GKVKL A+DATV+ ASRYG++G+PTIK F + G+S DYDGGR+ SDIV A D + P PE+ EI+N++I K CE+HQLCVVAVLP+ILD + RN Y+ L DKYK WGWLWTEA ELE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G PTI EPWDG+DGE+P E++IDLS++ +++
Sbjct: 60 LVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKK--DVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIF----QKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDD 486
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Celegans
Match: pdi-6 (Protein disulfide-isomerase A6 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q11067]) HSP 1 Score: 475.322 bits (1222), Expect = 6.863e-165 Identity = 230/425 (54.12%), Postives = 306/425 (72.00%), Query Frame = 3
Query: 111 MKYLSIVLFCFALAQCNADITEEEGVLVLTNSNF-NEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXX---XDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKE 1373
M + ++L A+ ++++ V+ LT +NF ++VI + +VEFYAPWCGHC+SL PE+KKAA+ALKGV KVGAVDM ++ S+G PY +QGFPT+KIFG K P DY G+RTA +I ++ L E + V +RLGG S GSSS S G G G +VVELTD+NF+++VL S++ WLVEFFAPWCGHCK+L+P W AASEL+GKV+LGALDATVHT A+++ ++G+PTIK+F G D+QDYDGGR SSDIV WAS + E +PAPE+ E +NQ++++ AC++ QLC+ A LP+ILDCQS+CRN+Y+A LK +K+K N WGW+W E P LE F +GGFGYPA+ +N RK KYA L G F + GI +F+RD+S G+G TS + GDG P I+ E WDGKDG +P E
Sbjct: 1 MALIKLLLASLAITSVCGMYSKKDDVVELTEANFQSKVINSDDIWIVEFYAPWCGHCKSLVPEYKKAASALKGVAKVGAVDMTQHQSVGGPYNVQGFPTLKIFGADKKKPTDYNGQRTAQAIADSVLAEAKKAVSARLGGKSSGSSSSGSGSGSGKRGGGGSGNEVVELTDANFEDLVLNSKDIWLVEFFAPWCGHCKSLEPQWKAAASELKGKVRLGALDATVHTVVANKFAIRGFPTIKYFAPGSDVSDAQDYDGGRQSSDIVAWASARAQENMPAPEVFEGINQQVVEDACKEKQLCIFAFLPHILDCQSECRNNYLAMLKEQSEKFKKNLWGWIWVEGAAQPALEESFEVGGFGYPAMTALNFRKNKYAVLKGSFGKDGIHEFLRDLSYGKGRTSSLRGDGFPKIQKTEKWDGKDGALPAE 425
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Celegans
Match: Y49E10.4 (pep chromosome:WBcel235:III:12378724:12380647:-1 gene:WBGene00013030.1 transcript:Y49E10.4.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y49E10.4) HSP 1 Score: 372.474 bits (955), Expect = 9.424e-125 Identity = 188/439 (42.82%), Postives = 279/439 (63.55%), Query Frame = 3
Query: 129 VLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHS-PKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSG-DSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIH----GDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEEPKSEL 1424
+L FA++ + T ++ V LT+SNF+ +V++ ++ +VEFYAP+CGHC+SL PE+KKAA LKG+ ++GA+D + + Y I+G+PTIKIFG ++ S P DY G RTA I +A K +++ + RL G S S K VV LTDSNFD++VL S+EPW+VEFFAPWCGHC+ L+P W +AA E+ G+VK GALDAT H + A ++G++G+PTIKFF G S D++DY GGR+S+D++ +A K + APE+ E + ++++ C+D QLC+ LP+I DCQS+CR I L +K +GW+W E ++ F IG +G+P L+ ++ +KM Y+T G FS GI++F+ V+ G+G I + I +PWDGKD E+P E+IDLS++ ++E K+EL
Sbjct: 7 ILLVFAISGSSTFYTAKDSVFELTDSNFDAKVLKSDRIWIVEFYAPYCGHCKSLVPEYKKAAKLLKGIAEIGAIDATVHQKIPLKYSIKGYPTIKIFGATEKSKPIDYNGPRTAKGIADAVKKSIEKSLEQRLKGKSSEKSKKSDKKGK--------VVVLTDSNFDKLVLNSKEPWMVEFFAPWCGHCQKLEPEWKKAAEEMGGRVKFGALDATAHESIAQKFGIRGFPTIKFFAPGTSSASDAEDYQGGRTSTDLISYAESKYDDFGAAPEVVEGTGKAVVETVCKDKQLCIFTFLPSIFDCQSKCRKQKIDMLNELATIFKKRSFGWVWMEGGAQENVQRAFEIGDYGFPVLIAMSPKKMMYSTQIGQFSVDGIKEFLNAVNYGKGRVLEIKPTHLSNNFLKIVETQPWDGKDKELPVMEDIDLSDVDMDE-KTEL 436
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Celegans
Match: Y49E10.4 (pep chromosome:WBcel235:III:12379000:12380647:-1 gene:WBGene00013030.1 transcript:Y49E10.4.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:Y49E10.4) HSP 1 Score: 372.474 bits (955), Expect = 9.424e-125 Identity = 188/439 (42.82%), Postives = 279/439 (63.55%), Query Frame = 3
Query: 129 VLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHS-PKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSG-DSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIH----GDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEEPKSEL 1424
+L FA++ + T ++ V LT+SNF+ +V++ ++ +VEFYAP+CGHC+SL PE+KKAA LKG+ ++GA+D + + Y I+G+PTIKIFG ++ S P DY G RTA I +A K +++ + RL G S S K VV LTDSNFD++VL S+EPW+VEFFAPWCGHC+ L+P W +AA E+ G+VK GALDAT H + A ++G++G+PTIKFF G S D++DY GGR+S+D++ +A K + APE+ E + ++++ C+D QLC+ LP+I DCQS+CR I L +K +GW+W E ++ F IG +G+P L+ ++ +KM Y+T G FS GI++F+ V+ G+G I + I +PWDGKD E+P E+IDLS++ ++E K+EL
Sbjct: 7 ILLVFAISGSSTFYTAKDSVFELTDSNFDAKVLKSDRIWIVEFYAPYCGHCKSLVPEYKKAAKLLKGIAEIGAIDATVHQKIPLKYSIKGYPTIKIFGATEKSKPIDYNGPRTAKGIADAVKKSIEKSLEQRLKGKSSEKSKKSDKKGK--------VVVLTDSNFDKLVLNSKEPWMVEFFAPWCGHCQKLEPEWKKAAEEMGGRVKFGALDATAHESIAQKFGIRGFPTIKFFAPGTSSASDAEDYQGGRTSTDLISYAESKYDDFGAAPEVVEGTGKAVVETVCKDKQLCIFTFLPSIFDCQSKCRKQKIDMLNELATIFKKRSFGWVWMEGGAQENVQRAFEIGDYGFPVLIAMSPKKMMYSTQIGQFSVDGIKEFLNAVNYGKGRVLEIKPTHLSNNFLKIVETQPWDGKDKELPVMEDIDLSDVDMDE-KTEL 436
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Celegans
Match: C14B9.2 (Probable protein disulfide-isomerase A4 [Source:UniProtKB/Swiss-Prot;Acc:P34329]) HSP 1 Score: 183.341 bits (464), Expect = 1.530e-50 Identity = 105/282 (37.23%), Postives = 160/282 (56.74%), Query Frame = 3
Query: 96 VLF*KMKYLSIVLFCFALAQCNADITEEE-------GVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRG---KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDK 911
++F + + +VL C + + D +++E GV+VLT+ NF+ ++KN VLV+FYAPWCGHC+ LAPE++KA++ K + + VD + LG+ + IQG+PT+K F K P DY G R IV E V SR+ +VV LT NFD+ + + E LVEF+APWCGHCK L P +++AA +L+ KVKLG +DAT+ ++YGV GYPT+K +++G DY+G R ++ I+++ +D+
Sbjct: 1 MMFDRRFFALVVLLCVSAVRSTEDASDDELNYEMDEGVVVLTDKNFDAFLKKNPSVLVKFYAPWCGHCKHLAPEYEKASS--KVSIPLAKVDATVETELGKRFEIQGYPTLK-FWKDGKGPNDYDGGRDEAGIV--------EWVESRV--------------DPNYKPPPEEVVTLTTENFDDFI-SNNELVLVEFYAPWCGHCKKLAPEYEKAAQKLKAQGSKVKLGKVDATIEKDLGTKYGVSGYPTMKI----IRNGRRFDYNGPREAAGIIKYMTDQ 252 HSP 2 Score: 76.6406 bits (187), Expect = 1.805e-14 Identity = 40/101 (39.60%), Postives = 62/101 (61.39%), Query Frame = 3
Query: 612 SNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRG---KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWAS 905
SNFD++V + L+EF+APWCGHCK+ + + + A L+ V L +DAT++ A S++ V+G+PTI F PAG KS + Y G R D+ ++ +
Sbjct: 507 SNFDKIVNDESKDVLIEFYAPWCGHCKSFESKYVELAQALKKTQPNVVLAKMDATINDA-PSQFAVEGFPTIYFAPAGKKS-EPIKYSGNRDLEDLKKFMT 605 HSP 3 Score: 61.2326 bits (147), Expect = 1.269e-9 Identity = 36/96 (37.50%), Postives = 55/96 (57.29%), Query Frame = 3
Query: 186 VLVLTNSNFNEVI-EKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV---VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHS-PKDYQGER 458
V + SNF++++ +++K VL+EFYAPWCGHC+S ++ + A ALK V + +D + Q + ++GFPTI K S P Y G R
Sbjct: 501 VKTVVGSNFDKIVNDESKDVLIEFYAPWCGHCKSFESKYVELAQALKKTQPNVVLAKMDATINDAPSQ-FAVEGFPTIYFAPAGKKSEPIKYSGNR 595
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Celegans
Match: pdi-2 (Protein disulfide-isomerase 2 [Source:UniProtKB/Swiss-Prot;Acc:Q17770]) HSP 1 Score: 114.39 bits (285), Expect = 1.221e-27 Identity = 56/118 (47.46%), Postives = 77/118 (65.25%), Query Frame = 3
Query: 132 LFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALK---GVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIV 476
LF L A I EEE V+VLT NF+EVI N+++LVEFYAPWCGHC+SLAPE+ KAAT LK +K+G +D + + + ++G+PT+K+F K P++Y G R SI+
Sbjct: 7 LFFLVLGASAAVIEEEENVIVLTKDNFDEVINGNEFILVEFYAPWCGHCKSLAPEYAKAATQLKEEGSDIKLGKLDATVHGEVSSKFEVRGYPTLKLFRNGK--PQEYNGGRDHDSII 122 HSP 2 Score: 107.842 bits (268), Expect = 2.496e-25 Identity = 57/141 (40.43%), Postives = 84/141 (59.57%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR---GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVV 1004
+V+ LT NFDE V+ E LVEF+APWCGHCK+L P + +AA++L+ +KLG LDATVH +S++ V+GYPT+K F ++G Q+Y+GGR I+ W K P K + + + +K E + V+
Sbjct: 24 NVIVLTKDNFDE-VINGNEFILVEFYAPWCGHCKSLAPEYAKAATQLKEEGSDIKLGKLDATVHGEVSSKFEVRGYPTLKLF----RNGKPQEYNGGRDHDSIIAWLKKKT-----GPVAKPLADADAVKELQESADVVVI 154 HSP 3 Score: 77.411 bits (189), Expect = 3.934e-15 Identity = 40/93 (43.01%), Postives = 48/93 (51.61%), Query Frame = 3
Query: 186 VLVLTNSNFNEVIEKN-KYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERT 461
V +L NF +V N K VLVEFYAPWCGHC+ LAP W K + MD + + IQ FPTIK F + DY G+RT
Sbjct: 243 VKILVGKNFEQVARDNTKNVLVEFYAPWCGHCKQLAPTWDKLGEKFADDESIVIAKMDSTLNEVEDVKIQSFPTIKFFPAGSNKVVDYTGDRT 335 HSP 4 Score: 73.9442 bits (180), Expect = 5.960e-14 Identity = 36/101 (35.64%), Postives = 56/101 (55.45%), Query Frame = 3
Query: 603 LTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRG--KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRW 899
L NF+++ + + LVEF+APWCGHCK L P WD+ + + + +D+T++ + +Q +PTIKFFPAG S DY G R+ ++
Sbjct: 246 LVGKNFEQVARDNTKNVLVEFYAPWCGHCKQLAPTWDKLGEKFADDESIVIAKMDSTLNEVEDVK--IQSFPTIKFFPAG--SNKVVDYTGDRTIEGFTKF 342
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Fly
Match: CaBP1 (gene:FBgn0025678 transcript:FBtr0345544) HSP 1 Score: 461.07 bits (1185), Expect = 2.464e-159 Identity = 235/420 (55.95%), Postives = 306/420 (72.86%), Query Frame = 3
Query: 123 SIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVK-SGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEE 1376
SI+L F + +A + +GV+ LT SNF+ EV++ + +VEFYAPWCGHCQSL PE+KK A ALKGVVKVG+V+ D S+L +G++GFPTIKIFG +K SP DY G+RTA +I AAL E+ + V+ LGG G SS SSG DV+ELT+ NFD++VL S++ WLVEFFAPWCGHCKNL P W +AA EL+GKVKLGALDAT H + A+ Y V+GYPTIKFFPAG K + D+Q+YDGGR++SDIV WASDK V +PAPE+ EI+N+ ++ACE LCVV+VLP+ILDC ++CRN ++ TL+ G+K+K +WGW W E + LE +GGFGYPA+ VVN +KMK++ L G FS+ GI +F+RD+S GRG T+ + G P I SV+PWDGKDG++P EE
Sbjct: 6 SILLLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALKGVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSGSSSGD------DVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELKGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEIINESTFETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWAEGGQQLALEESLEVGGFGYPAMAVVNFKKMKFSVLKGSFSKDGINEFLRDISYGRGHTAPVRGAKKPAIVSVDPWDGKDGQLPTEE 419
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Fly
Match: CaBP1 (gene:FBgn0025678 transcript:FBtr0080837) HSP 1 Score: 461.07 bits (1185), Expect = 2.464e-159 Identity = 235/420 (55.95%), Postives = 306/420 (72.86%), Query Frame = 3
Query: 123 SIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVK-SGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEE 1376
SI+L F + +A + +GV+ LT SNF+ EV++ + +VEFYAPWCGHCQSL PE+KK A ALKGVVKVG+V+ D S+L +G++GFPTIKIFG +K SP DY G+RTA +I AAL E+ + V+ LGG G SS SSG DV+ELT+ NFD++VL S++ WLVEFFAPWCGHCKNL P W +AA EL+GKVKLGALDAT H + A+ Y V+GYPTIKFFPAG K + D+Q+YDGGR++SDIV WASDK V +PAPE+ EI+N+ ++ACE LCVV+VLP+ILDC ++CRN ++ TL+ G+K+K +WGW W E + LE +GGFGYPA+ VVN +KMK++ L G FS+ GI +F+RD+S GRG T+ + G P I SV+PWDGKDG++P EE
Sbjct: 6 SILLLAFVVGSVSAFYSPSDGVVELTPSNFDREVLKDDAIWVVEFYAPWCGHCQSLVPEYKKLAKALKGVVKVGSVNADADSTLSGQFGVRGFPTIKIFGANKKSPTDYNGQRTAKAIAEAALAEVKKKVQGVLGGGGGSSSGGSGSSSGD------DVIELTEDNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPEWAKAAKELKGKVKLGALDATAHQSKAAEYNVRGYPTIKFFPAGSKRASDAQEYDGGRTASDIVSWASDKHVANVPAPELIEIINESTFETACEGKPLCVVSVLPHILDCDAKCRNKFLDTLRTLGEKFKQKQWGWAWAEGGQQLALEESLEVGGFGYPAMAVVNFKKMKFSVLKGSFSKDGINEFLRDISYGRGHTAPVRGAKKPAIVSVDPWDGKDGQLPTEE 419
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Fly
Match: CG9302 (gene:FBgn0032514 transcript:FBtr0080470) HSP 1 Score: 130.183 bits (326), Expect = 3.168e-32 Identity = 87/255 (34.12%), Postives = 132/255 (51.76%), Query Frame = 3
Query: 159 NADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVG---AVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRG--KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASD 908
+AD E ++ LT+ F ++ K LV FYAPWCGHC+ + PE++KAA +K G A+D K S+ + Y ++G+PT+K F S K R A IV E +R + S +V+ L D NF LK ++ LV F+APWCGHCK+ KP + AA+ L+ ++ A+D T A ++Y V+GYPTI +F + +K+ DY+GGR+S D + + ++
Sbjct: 266 SADTNSE--IVHLTSQGFEPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALEMKQKKIPGLLAALDATKEPSIAEKYKVKGYPTVKFF--SNGVFKFEVNVREASKIV--------EFMRDP----KEPPPPPPPEKSWEEEEDSKEVLFLDDDNFSS-TLKRKKHALVMFYAPWCGHCKHTKPEFTAAATALQDDPRIAFVAIDCTKLAALCAKYNVRGYPTILYF-SYLKT--KLDYNGGRTSKDFIAYMNN 500 HSP 2 Score: 120.553 bits (301), Expect = 6.935e-29 Identity = 82/245 (33.47%), Postives = 129/245 (52.65%), Query Frame = 3
Query: 204 SNFNEVIEKN-KYVLVEFYAPWCGHCQSLAPEWKKAATALKG----VVKVGAVDMDKYSSLGQPYGIQGFPTIKIF--GKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKV---KLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASD 908
++F + + K+ + +LV FY PWCG C+ + PE+ KA+T LK ++ V+ + + + + + I GFPT+ F GK + + Y+GE ++V+ L + + K S+ + ++V LT F E LK E+ LV F+APWCGHCK +KP +++AA E++ K L ALDAT + A +Y V+GYPT+KFF GV + R +S IV + D
Sbjct: 152 ASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKASTELKTKGGYILAAMNVERQENAPIRKMFNITGFPTLIYFENGKLRFT---YEGENNKEALVSFMLNP-------------NAKPTPKPKEPEWSADTNSEIVHLTSQGF-EPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALEMKQKKIPGLLAALDATKEPSIAEKYKVKGYPTVKFFSNGVFKFEV----NVREASKIVEFMRD 375 HSP 3 Score: 58.9214 bits (141), Expect = 7.383e-9 Identity = 34/121 (28.10%), Postives = 61/121 (50.41%), Query Frame = 3
Query: 591 DVVELTDS-NFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK--VKLGALDATVHTATASR--YGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPE 938
DV+ +D+ +F + + K P LV F+ PWCG CK +KP + +A++EL+ K L A++ R + + G+PT+ +F G Y+G + +V + + + P P+
Sbjct: 144 DVLHFSDAASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKASTELKTKGGYILAAMNVERQENAPIRKMFNITGFPTLIYFENGKLRF---TYEGENNKEALVSFMLNPNAKPTPKPK 261
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Fly
Match: Pdi (gene:FBgn0286818 transcript:FBtr0346644) HSP 1 Score: 108.997 bits (271), Expect = 4.418e-25 Identity = 56/128 (43.75%), Postives = 77/128 (60.16%), Query Frame = 3
Query: 111 MKYLSIVLF---CFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATAL---KGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIV 476
MK+L LF + A A++ EEGVLV T NF ++I N++VLVEFYAPWCGHC++LAPE+ KAA L + +K+ VD L + Y ++G+PT+K F SP +Y G R A I+
Sbjct: 1 MKFLICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSG--SPVEYSGGRQAADII 126 HSP 2 Score: 98.2117 bits (243), Expect = 1.682e-21 Identity = 52/146 (35.62%), Postives = 84/146 (57.53%), Query Frame = 3
Query: 594 VVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNI 1022
V+ T NF +++ +E LVEF+APWCGHCK L P + +AA +L K +KL +DATV A +Y V+GYPT+KFF +SG +Y GGR ++DI+ W + K P K++ + + +D+++ ++ ++
Sbjct: 29 VLVATVDNFKQLIADNE-FVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFF----RSGSPVEYSGGRQAADIIAWVTKKT-----GPPAKDLTSVADAEQFLKDNEIAIIGFFKDL 164 HSP 3 Score: 77.0258 bits (188), Expect = 1.241e-14 Identity = 41/98 (41.84%), Postives = 55/98 (56.12%), Query Frame = 3
Query: 186 VLVLTNSNFNEV-IEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIV 476
V VL +SNF V ++K+K VLVEFYAPWCGHC+ LAP + + A K + MD ++ + I FPTIK F K + D+ +RT V
Sbjct: 369 VKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYFRKEDNKVIDFNLDRTLDDFV 466 HSP 4 Score: 67.781 bits (164), Expect = 1.144e-11 Identity = 34/103 (33.01%), Postives = 59/103 (57.28%), Query Frame = 3
Query: 603 LTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK--VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQ--DYDGGRSSSDIVRW 899
L SNF+ + L + LVEF+APWCGHCK L P +DQ A + + + + +D+T + + + + +PTIK+F + D++ D++ R+ D V++
Sbjct: 372 LVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIK--ISSFPTIKYF----RKEDNKVIDFNLDRTLDDFVKF 468
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Fly
Match: Pdi (gene:FBgn0286818 transcript:FBtr0075648) HSP 1 Score: 108.997 bits (271), Expect = 4.418e-25 Identity = 56/128 (43.75%), Postives = 77/128 (60.16%), Query Frame = 3
Query: 111 MKYLSIVLF---CFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATAL---KGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIV 476
MK+L LF + A A++ EEGVLV T NF ++I N++VLVEFYAPWCGHC++LAPE+ KAA L + +K+ VD L + Y ++G+PT+K F SP +Y G R A I+
Sbjct: 1 MKFLICALFLAASYVAASAEAEVKVEEGVLVATVDNFKQLIADNEFVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFFRSG--SPVEYSGGRQAADII 126 HSP 2 Score: 98.2117 bits (243), Expect = 1.682e-21 Identity = 52/146 (35.62%), Postives = 84/146 (57.53%), Query Frame = 3
Query: 594 VVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNI 1022
V+ T NF +++ +E LVEF+APWCGHCK L P + +AA +L K +KL +DATV A +Y V+GYPT+KFF +SG +Y GGR ++DI+ W + K P K++ + + +D+++ ++ ++
Sbjct: 29 VLVATVDNFKQLIADNE-FVLVEFYAPWCGHCKALAPEYAKAAQQLAEKESPIKLAKVDATVEGELAEQYAVRGYPTLKFF----RSGSPVEYSGGRQAADIIAWVTKKT-----GPPAKDLTSVADAEQFLKDNEIAIIGFFKDL 164 HSP 3 Score: 77.0258 bits (188), Expect = 1.241e-14 Identity = 41/98 (41.84%), Postives = 55/98 (56.12%), Query Frame = 3
Query: 186 VLVLTNSNFNEV-IEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIV 476
V VL +SNF V ++K+K VLVEFYAPWCGHC+ LAP + + A K + MD ++ + I FPTIK F K + D+ +RT V
Sbjct: 369 VKVLVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIKISSFPTIKYFRKEDNKVIDFNLDRTLDDFV 466 HSP 4 Score: 67.781 bits (164), Expect = 1.144e-11 Identity = 34/103 (33.01%), Postives = 59/103 (57.28%), Query Frame = 3
Query: 603 LTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK--VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQ--DYDGGRSSSDIVRW 899
L SNF+ + L + LVEF+APWCGHCK L P +DQ A + + + + +D+T + + + + +PTIK+F + D++ D++ R+ D V++
Sbjct: 372 LVSSNFESVALDKSKSVLVEFYAPWCGHCKQLAPIYDQLAEKYKDNEDIVIAKMDSTANELESIK--ISSFPTIKYF----RKEDNKVIDFNLDRTLDDFVKF 468
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Zebrafish
Match: pdia6 (protein disulfide isomerase family A, member 6 [Source:ZFIN;Acc:ZDB-GENE-030131-879]) HSP 1 Score: 470.315 bits (1209), Expect = 1.016e-162 Identity = 239/427 (55.97%), Postives = 305/427 (71.43%), Query Frame = 3
Query: 111 MKYLSIVLFC-FALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKE 1373
M+ L VL C + T + V+ L SNFN EVI+ + LVEFYAPWCGHC+SLAPEWKKAATALKG+VKVGAVD D+++SLG YG++GFPTIKIFG +KH P+DYQG RT +IV+AAL L LV+ RLGG +GGS + G + DVVELTD NFD VL+S++ WLVEFFAPWCGHCKNL+P W AA+E++ GKVKL A+DATVH ASR+G++G+PTIK F G + +DY GGR+ SDIV A + + +PAPE++E+LN+ ILK CED+QLC++AVLP+ILD + RN Y+ +K +KYK WGWLWTEA ELE GIGGFGYPA+ +N RKMK+A L G FS++GI +F+R++S+GRGST+ + G LP I +V+ WDGKDGE+P E
Sbjct: 1 MRALLGVLACSLTVLSAYGLYTSSDDVVELNPSNFNREVIQSDSLWLVEFYAPWCGHCKSLAPEWKKAATALKGIVKVGAVDADQHNSLGGQYGVRGFPTIKIFGGNKHKPEDYQGGRTNQAIVDAALNALRSLVKDRLGGKTGGSDYSRQSGGGAGNKK--DVVELTDDNFDRTVLESDDVWLVEFFAPWCGHCKNLEPEWTAAATEVKEQTKGKVKLAAVDATVHQGLASRFGIRGFPTIKVFRKGE---EPEDYQGGRTRSDIVARALELYSDNIPAPELQEVLNEGILKKTCEDYQLCIIAVLPHILDTGASGRNSYLEVMKTMAEKYKKKMWGWLWTEAGAQMELEASLGIGGFGYPAMAAINSRKMKFALLKGSFSETGIHEFLRELSVGRGSTATVGGGALPKINTVQAWDGKDGELPME 422
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Zebrafish
Match: pdia4 (protein disulfide isomerase family A, member 4 [Source:ZFIN;Acc:ZDB-GENE-030131-5493]) HSP 1 Score: 173.711 bits (439), Expect = 9.606e-47 Identity = 101/254 (39.76%), Postives = 141/254 (55.51%), Query Frame = 3
Query: 168 ITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALK---GVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDK 911
+ EE GVLVLT++NF+ IE VLVEFYAPWCGHC+ APE++K A LK + V VD K S LG + + G+PTIKI K + P DY G+R+ +IV + + E+ + + LT NFD+ V+ + + LVEF+APWCGHCK L P +++AA EL + + L +DAT + A+R+GV GYPT+K F + G + DY+G R IV + SD+
Sbjct: 55 VKEENGVLVLTDANFDTFIEGKDTVLVEFYAPWCGHCKQFAPEYEKIAQTLKENDPPIPVAKVDATKASGLGSRFEVSGYPTIKILKKGE--PLDYDGDRSEHAIV----ERVKEVAQPDWKPPPEA------------------TLVLTKDNFDD-VVNNADIILVEFYAPWCGHCKRLAPEYEKAAKELSNRTPPIPLAKVDATAESDLATRFGVSGYPTLKIF----RKGKAFDYNGPREKFGIVDYMSDQ 279 HSP 2 Score: 94.3597 bits (233), Expect = 6.195e-20 Identity = 76/235 (32.34%), Postives = 110/235 (46.81%), Query Frame = 3
Query: 594 VVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQ---LPAPEIKEILNQEILKSACEDHQLCVVAVL-PNILDCQSQCRNDYIATLKVAGDKYKSNRWGWL---WTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRD 1268
V+ LTD+NFD + + ++ LVEF+APWCGHCK P +++ A L+ + + +DAT + SR+ V GYPTIK +K G+ DYDG RS IV K V Q P PE +L ++ + + +V P C+ +A K SNR + +A +L FG+ GYP L + RK K GP + GI D++ D
Sbjct: 61 VLVLTDANFDTFI-EGKDTVLVEFYAPWCGHCKQFAPEYEKIAQTLKENDPPIPVAKVDATKASGLGSRFEVSGYPTIKI----LKKGEPLDYDGDRSEHAIVERV--KEVAQPDWKPPPEATLVLTKDNFDDVVNNADIILVEFYAPWCGHCKR------LAPEYEKAAKELSNRTPPIPLAKVDATAESDLATRFGVS--GYPTLKI--FRKGKAFDYNGPREKFGIVDYMSD 278 HSP 3 Score: 94.3597 bits (233), Expect = 6.419e-20 Identity = 52/127 (40.94%), Postives = 69/127 (54.33%), Query Frame = 3
Query: 180 EGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV---VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVN-------------AALKELDELVR 512
E LVLT NF++V+ +LVEFYAPWCGHC+ LAPE++KAA L + + VD S L +G+ G+PT+KIF K K DY G R IV+ LK++ EL+R
Sbjct: 174 EATLVLTKDNFDDVVNNADIILVEFYAPWCGHCKRLAPEYEKAAKELSNRTPPIPLAKVDATAESDLATRFGVSGYPTLKIFRKGKAF--DYNGPREKFGIVDYMSDQAGPPSKQVQTLKQVQELLR 298 HSP 4 Score: 71.2478 bits (173), Expect = 1.292e-12 Identity = 33/89 (37.08%), Postives = 53/89 (59.55%), Query Frame = 3
Query: 615 NFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKL--GALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGR 875
FDE+V+ S++ L+EF+APWCGHCK L+P + + + + L +DAT + Y V+G+PTI F P+ K + ++GG+
Sbjct: 531 TFDEIVMDSKKDVLIEFYAPWCGHCKKLEPDYISLGKKYKNEKNLVIAKMDATANDVPHDSYKVEGFPTIYFAPSNNKQNPIK-FEGGK 618 HSP 5 Score: 57.7658 bits (138), Expect = 2.334e-8 Identity = 33/94 (35.11%), Postives = 50/94 (53.19%), Query Frame = 3
Query: 186 VLVLTNSNFNEVI-EKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSS--LGQPYGIQGFPTIKIFGKS--KHSPKDYQG 452
V V+ F+E++ + K VL+EFYAPWCGHC+ L P++ K + MD ++ Y ++GFPTI F S K +P ++G
Sbjct: 524 VKVVVGKTFDEIVMDSKKDVLIEFYAPWCGHCKKLEPDYISLGKKYKNEKNLVIAKMDATANDVPHDSYKVEGFPTI-YFAPSNNKQNPIKFEG 616
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Zebrafish
Match: dnajc10 (DnaJ (Hsp40) homolog, subfamily C, member 10 [Source:ZFIN;Acc:ZDB-GENE-070327-1]) HSP 1 Score: 133.65 bits (335), Expect = 1.216e-32 Identity = 68/223 (30.49%), Postives = 111/223 (49.78%), Query Frame = 3
Query: 186 VLVLTNSNFNEVIEKNKYV---LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQG----ERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPA 833
V+ L +F E++++ K +V+FYAPWCG CQ+L PEW++ A L G+V VG VD K+ S Q ++ +P I++F ++ + YQ R A S+ AL L V+L+ +F VL ++ W+++F+APWCG C+ P ++ A ++G V+ G +D H T G++ YPT++F+P
Sbjct: 554 VVTLGPESFQELVKRRKSSETWMVDFYAPWCGPCQALLPEWRRMARMLSGIVNVGTVDCQKHHSFCQSESVRAYPEIRLFPQNSNRRDQYQTYNGWHRDAFSLKAWALSSLPRA-----------------------------SVDLSPEDFKRKVLGGKDHWVLDFYAPWCGPCQQFAPEFEVLARMMKGTVRAGKVDCQAHYQTCQSAGIKAYPTVRFYPT 747 HSP 2 Score: 122.865 bits (307), Expect = 4.262e-29 Identity = 76/224 (33.93%), Postives = 108/224 (48.21%), Query Frame = 3
Query: 243 LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMV--LKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDS-QDYDG-GRSSSDIVRWA 902
LV+F+APWC C++L PE +KA+ L G +K G +D + L Y I +PT IF KS S +Y+G +A I L+ +++LV VV L +F E+V KS E W+V+F+APWCG C+ L P W + A L G V +G +D H + V+ YP I+ FP D Q Y+G R + + WA
Sbjct: 468 LVDFFAPWCPPCRALLPELRKASIQLFGQLKFGTLDCTIHEGLCNTYNIHAYPTTVIFNKS--SIHEYEGHHSADGI----LEFIEDLVNPV-------------------------VVTLGPESFQELVKRRKSSETWMVDFYAPWCGPCQALLPEWRRMARMLSGIVNVGTVDCQKHHSFCQSESVRAYPEIRLFPQNSNRRDQYQTYNGWHRDAFSLKAWA 660 HSP 3 Score: 77.411 bits (189), Expect = 1.811e-14 Identity = 65/243 (26.75%), Postives = 101/243 (41.56%), Query Frame = 3
Query: 192 VLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV-VKVGAVDMDKYSSLGQPYGIQGFPTIKIF-GKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKV 914
+LT S+F + +++ LV F G + E+KK LK ++VG VD S L I P + +F G H + + G+ ++V A + ++ V L NF +EPWLV+FFAPWC C+ L P +A+ +L G++K G LD T+H + Y + YPT F +Y+G S+ I+ + D V
Sbjct: 349 ILTKSSFEHKLAHHRW-LVSFSF---GRNDLASHEYKKLNALLKNSHIQVGKVDCISDSELCSSLYIHK-PCVAVFKGVGIHDFEIHHGKDALYNVVAFAKESVN-----------------------------AHVTTLRPENFPN---HEKEPWLVDFFAPWCPPCRALLPELRKASIQLFGQLKFGTLDCTIHEGLCNTYNIHAYPTTVIF----NKSSIHEYEGHHSADGILEFIEDLV 550 HSP 4 Score: 70.0922 bits (170), Expect = 4.179e-12 Identity = 30/102 (29.41%), Postives = 55/102 (53.92%), Query Frame = 3
Query: 186 VLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALK 491
+ L +F+ + + V FY P C HC LAP W++ A + GV+++GAV+ L + GI +P++ +F ++ +P+ Y +RT S+ A++
Sbjct: 130 ITTLDRGDFDAAVNSGEVWFVNFYFPRCSHCHDLAPTWREFAKEMDGVIRIGAVNCGDNGMLCRSKGINSYPSLYVF-RAGMNPEKYFNDRTKSSLTKFAMQ 230 HSP 5 Score: 67.0106 bits (162), Expect = 3.691e-11 Identity = 35/97 (36.08%), Postives = 53/97 (54.64%), Query Frame = 3
Query: 228 KNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGE----RTAGSIVNAALKELDEL 506
K+ +VL +FYAPWCG CQ APE++ A +KG V+ G VD + Q GI+ +PT++ + + +D GE R A I + + L +L
Sbjct: 684 KDHWVL-DFYAPWCGPCQQFAPEFEVLARMMKGTVRAGKVDCQAHYQTCQSAGIKAYPTVRFYPTLGTTRRDQGGEHINSRDATVIADILRQRLQQL 779 HSP 6 Score: 63.5438 bits (153), Expect = 4.141e-10 Identity = 31/104 (29.81%), Postives = 54/104 (51.92%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWA 902
++ L +FD V S E W V F+ P C HC +L P W + A E+ G +++GA++ + G+ YP++ F AG+ + + Y R+ S + ++A
Sbjct: 129 EITTLDRGDFDAAV-NSGEVWFVNFYFPRCSHCHDLAPTWREFAKEMDGVIRIGAVNCGDNGMLCRSKGINSYPSLYVFRAGM---NPEKYFNDRTKSSLTKFA 228
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Zebrafish
Match: txndc5 (thioredoxin domain containing 5 [Source:ZFIN;Acc:ZDB-GENE-040426-1951]) HSP 1 Score: 128.642 bits (322), Expect = 4.039e-32 Identity = 82/254 (32.28%), Postives = 135/254 (53.15%), Query Frame = 3
Query: 180 EGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALK--GVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQ-AASELRG--KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRS----SSDIVRWASDKV 914
+G+ LT +NF I K + V+F+APWCGHC+++AP W++ A++ + +K+ VD ++ + ++G+PT+ F + + Y+G+R S + + S+ +HE S +V+ LT+SNFDE V K ++F+APWCGHCKNL P WD + E G VK+ +D TV +R+ V+GYPT+ F AG + ++++GGR S I++ A D++
Sbjct: 158 QGLYELTATNFKSHIAKGSH-FVKFFAPWCGHCKAMAPTWEQLASSFEHSDSIKISKVDCTQHYEVCSDNQVRGYPTLLFFTDGEKIDQ-YKGKRDLDSFKEFVDNHV-KAAESKDEPEKEEEHTHEIPPSAEPEKQESNVLVLTESNFDETVAKGLS--FIKFYAPWCGHCKNLAPTWDDLSQKEFPGLTDVKIAKVDCTVERTLCNRFSVRGYPTLLMFRAGQQ---GEEHNGGRDLESLHSFIMKQARDEL 403 HSP 2 Score: 126.716 bits (317), Expect = 2.022e-31 Identity = 100/311 (32.15%), Postives = 138/311 (44.37%), Query Frame = 3
Query: 117 YLSIVLFCFALAQCNADITEEEGV-LVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKG-------VVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAAS--ELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASD--KVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVL 1013
++ + L C L+ C+ D E+E T FN+ I + V F+APWCGHCQ L W + A VVKV K+ S+ +GI+G+PT+K+F + + K YQG R ++ N LK L E ++ + ELT +NF + K V+FFAPWCGHCK + P W+Q AS E +K+ +D T H S V+GYPT+ FF G K Y G R + + K E PE +E EI SA + Q V VL
Sbjct: 8 FIYLALLCSRLS-CDNDTEEDEHAKHTYTVEMFNDAISTAPH-FVMFFAPWCGHCQRLQGTWNELADKYNSMEAPPAYVVKVDCTKDTKFCSI--EHGIRGYPTLKLFKPEQEAVK-YQGPRDLQALENWMLKTLQEEPEEPQSEPEPPKVPEPKQG----------LYELTATNFKSHIAKGSH--FVKFFAPWCGHCKAMAPTWEQLASSFEHSDSIKISKVDCTQHYEVCSDNQVRGYPTLLFFTDGEK---IDQYKGKRDLDSFKEFVDNHVKAAESKDEPEKEEEHTHEIPPSAEPEKQESNVLVL 298 HSP 3 Score: 72.4034 bits (176), Expect = 3.008e-13 Identity = 41/115 (35.65%), Postives = 67/115 (58.26%), Query Frame = 3
Query: 174 EEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKK-AATALKGV--VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKEL-DEL 506
+E VLVLT SNF+E + K ++FYAPWCGHC++LAP W + G+ VK+ VD +L + ++G+PT+ +F ++ +++ G R S+ + +K+ DEL
Sbjct: 291 QESNVLVLTESNFDETVAKG-LSFIKFYAPWCGHCKNLAPTWDDLSQKEFPGLTDVKIAKVDCTVERTLCNRFSVRGYPTLLMF-RAGQQGEEHNGGRDLESLHSFIMKQARDEL 403
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Zebrafish
Match: p4hb (prolyl 4-hydroxylase, beta polypeptide [Source:ZFIN;Acc:ZDB-GENE-080610-1]) HSP 1 Score: 116.316 bits (290), Expect = 2.812e-27 Identity = 59/124 (47.58%), Postives = 79/124 (63.71%), Query Frame = 3
Query: 120 LSIVLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV---VKVGAVDMDKYSSLGQPYGIQGFPTIKIF-GKSKHSPKDYQGERTAGSIVN 479
L ++ C A A+I EEE VLVL SNF E ++ + VLVEFYAPWCGHC++LAPE+ KAA LK +++ VD + S L Q +G++G+PTIK F G K +PK+Y R A IV+
Sbjct: 2 LKFLIVCALAAMSAAEIAEEEDVLVLKKSNFEEALKAHPNVLVEFYAPWCGHCKALAPEYSKAAGMLKAEGSDIRLAKVDATEESELAQEFGVRGYPTIKFFKGGEKGNPKEYSAGRQAEDIVS 125 HSP 2 Score: 105.145 bits (261), Expect = 1.178e-23 Identity = 61/167 (36.53%), Postives = 92/167 (55.09%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGD 1082
DV+ L SNF+E LK+ LVEF+APWCGHCK L P + +AA L+ + ++L +DAT + A +GV+GYPTIKFF G K G+ ++Y GR + DIV W + A + +++ E S D+++ V+ D +S+ +I T + D
Sbjct: 23 DVLVLKKSNFEE-ALKAHPNVLVEFYAPWCGHCKALAPEYSKAAGMLKAEGSDIRLAKVDATEESELAQEFGVRGYPTIKFFKGGEK-GNPKEYSAGRQAEDIVSWLKKRT--GPAATTLNDVMQAE---SIIADNEVAVIGFFK---DVESEDSKAFIKTAEAVDD 179 HSP 3 Score: 73.9442 bits (180), Expect = 1.361e-13 Identity = 36/101 (35.64%), Postives = 53/101 (52.48%), Query Frame = 3
Query: 603 LTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR--GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRW 899
L NF+E+ VEF+APWCGHCK L P WDQ + + + + +D+T + A + V +PT+KFFPAG DY+G R+ ++
Sbjct: 370 LVGKNFEEVAFNPANNVFVEFYAPWCGHCKQLAPIWDQLGEKFKDNANIVVAKMDSTANEIEAVK--VHSFPTLKFFPAG-DERKVIDYNGERTLDGFTKF 467 HSP 4 Score: 71.2478 bits (173), Expect = 1.264e-12 Identity = 43/125 (34.40%), Postives = 58/125 (46.40%), Query Frame = 3
Query: 123 SIVLFCFALAQ-------CNADITEE---EGVLVLTNSNFNEV-IEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIF-GKSKHSPKDYQGERT 461
+I+ FC + + + DI E+ V VL NF EV V VEFYAPWCGHC+ LAP W + K + MD ++ + + FPT+K F + DY GERT
Sbjct: 336 NIISFCTSFVEGTLKPHLMSQDIPEDWDKNPVKVLVGKNFEEVAFNPANNVFVEFYAPWCGHCKQLAPIWDQLGEKFKDNANIVVAKMDSTANEIEAVKVHSFPTLKFFPAGDERKVIDYNGERT 460
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Xenopus
Match: mettl16 (methyltransferase like 16 [Source:Xenbase;Acc:XB-GENE-952802]) HSP 1 Score: 462.225 bits (1188), Expect = 2.128e-159 Identity = 236/437 (54.00%), Postives = 303/437 (69.34%), Query Frame = 3
Query: 114 KYLSIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
K L + C +A + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L P+WKKAATALKGVVK+GAV+ D++ SLG YG++GFPTIK+FG +K+ P DYQG RTA +I++AAL L V+ RLGG SGGS S + S G DV++LTD FD+ VL S++ W VEF+APWCGHCKNL+P W AA+E++ GKVKL A+DATV ASRYG++G+PTIK F G D DYDGGR+ +DIV A D E P PEI EILN +I+K C++HQLC+VAVLP+ILD + RN Y+ + DKYK WGWLW EA +LE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGSTS + G +P I +V PWDGKDGE+P E++IDLS++ +++
Sbjct: 8 KLLGGAVACTLFMAASAMYSPSDDVIELTPSNFNKEVIQSDSLWLVEFYAPWCGHCQRLTPDWKKAATALKGVVKIGAVNADQHQSLGGQYGVRGFPTIKVFGANKNKPDDYQGGRTADAIIDAALSSLRSFVKDRLGGRSGGSDSGRQSYSSGGGSKK-DVIDLTDDTFDKNVLNSDDVWFVEFYAPWCGHCKNLEPEWAAAATEIKQQTNGKVKLAAVDATVSQVLASRYGIRGFPTIKIFQKGE---DPVDYDGGRTKADIVARAIDLFSENAPPPEIYEILNGDIVKKTCDEHQLCIVAVLPHILDTGASGRNSYLDVMMKMADKYKKKMWGWLWAEAGAQMDLETSLGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTSPVGGGAIPKINTVVPWDGKDGELPAEDDIDLSDVELDD 440
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Xenopus
Match: mettl16 (methyltransferase like 16 [Source:Xenbase;Acc:XB-GENE-952802]) HSP 1 Score: 461.07 bits (1185), Expect = 5.162e-159 Identity = 232/429 (54.08%), Postives = 297/429 (69.23%), Query Frame = 3
Query: 138 CFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
C +A + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L P+WKKAATALKGVVK+GAV+ D++ SLG YG++GFPTIK+FG +K+ P DYQG RTA +I++AAL L V+ RLGG SGGS S DV++LTD FD+ VL S++ W VEF+APWCGHCKNL+P W AA+E++ GKVKL A+DATV ASRYG++G+PTIK F G D DYDGGR+ +DIV A D E P PEI EILN +I+K C++HQLC+VAVLP+ILD + RN Y+ + DKYK WGWLW EA +LE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGSTS + G +P I +V PWDGKDGE+P E++IDLS++ +++
Sbjct: 16 CTLFMAASAMYSPSDDVIELTPSNFNKEVIQSDSLWLVEFYAPWCGHCQRLTPDWKKAATALKGVVKIGAVNADQHQSLGGQYGVRGFPTIKVFGANKNKPDDYQGGRTADAIIDAALSSLRSFVKDRLGGRSGGSDSGSSGGGSKK-----DVIDLTDDTFDKNVLNSDDVWFVEFYAPWCGHCKNLEPEWAAAATEIKQQTNGKVKLAAVDATVSQVLASRYGIRGFPTIKIFQKG---EDPVDYDGGRTKADIVARAIDLFSENAPPPEIYEILNGDIVKKTCDEHQLCIVAVLPHILDTGASGRNSYLDVMMKMADKYKKKMWGWLWAEAGAQMDLETSLGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTSPVGGGAIPKINTVVPWDGKDGELPAEDDIDLSDVELDD 436
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Xenopus
Match: mettl16 (methyltransferase like 16 [Source:Xenbase;Acc:XB-GENE-952802]) HSP 1 Score: 461.455 bits (1186), Expect = 6.385e-159 Identity = 234/429 (54.55%), Postives = 300/429 (69.93%), Query Frame = 3
Query: 138 CFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
C +A + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L P+WKKAATALKGVVK+GAV+ D++ SLG YG++GFPTIK+FG +K+ P DYQG RTA +I++AAL L V+ RLGG SGGS S + S G DV++LTD FD+ VL S++ W VEF+APWCGHCKNL+P W AA+E++ GKVKL A+DATV ASRYG++G+PTIK F G D DYDGGR+ +DIV A D E P PEI EILN +I+K C++HQLC+VAVLP+ILD + RN Y+ + DKYK WGWLW EA +LE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGSTS + G +P I +V PWDGKDGE+P E++IDLS++ +++
Sbjct: 23 CTLFMAASAMYSPSDDVIELTPSNFNKEVIQSDSLWLVEFYAPWCGHCQRLTPDWKKAATALKGVVKIGAVNADQHQSLGGQYGVRGFPTIKVFGANKNKPDDYQGGRTADAIIDAALSSLRSFVKDRLGGRSGGSDSGRQSYSSGGGSKK-DVIDLTDDTFDKNVLNSDDVWFVEFYAPWCGHCKNLEPEWAAAATEIKQQTNGKVKLAAVDATVSQVLASRYGIRGFPTIKIFQKGE---DPVDYDGGRTKADIVARAIDLFSENAPPPEIYEILNGDIVKKTCDEHQLCIVAVLPHILDTGASGRNSYLDVMMKMADKYKKKMWGWLWAEAGAQMDLETSLGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTSPVGGGAIPKINTVVPWDGKDGELPAEDDIDLSDVELDD 447
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Xenopus
Match: mettl16 (methyltransferase like 16 [Source:Xenbase;Acc:XB-GENE-952802]) HSP 1 Score: 461.07 bits (1185), Expect = 6.580e-159 Identity = 233/429 (54.31%), Postives = 299/429 (69.70%), Query Frame = 3
Query: 138 CFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
C +A + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L P+WKKAATALKGVVK+GAV+ D++ SLG YG++GFPTIK+FG +K+ P DYQG RTA +I++AAL L V+ RLGG SGGS S + G DV++LTD FD+ VL S++ W VEF+APWCGHCKNL+P W AA+E++ GKVKL A+DATV ASRYG++G+PTIK F G D DYDGGR+ +DIV A D E P PEI EILN +I+K C++HQLC+VAVLP+ILD + RN Y+ + DKYK WGWLW EA +LE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGSTS + G +P I +V PWDGKDGE+P E++IDLS++ +++
Sbjct: 15 CTLFMAASAMYSPSDDVIELTPSNFNKEVIQSDSLWLVEFYAPWCGHCQRLTPDWKKAATALKGVVKIGAVNADQHQSLGGQYGVRGFPTIKVFGANKNKPDDYQGGRTADAIIDAALSSLRSFVKDRLGGRSGGSDSGRQVGFSGYIKK--DVIDLTDDTFDKNVLNSDDVWFVEFYAPWCGHCKNLEPEWAAAATEIKQQTNGKVKLAAVDATVSQVLASRYGIRGFPTIKIFQKG---EDPVDYDGGRTKADIVARAIDLFSENAPPPEIYEILNGDIVKKTCDEHQLCIVAVLPHILDTGASGRNSYLDVMMKMADKYKKKMWGWLWAEAGAQMDLETSLGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTSPVGGGAIPKINTVVPWDGKDGELPAEDDIDLSDVELDD 438
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Xenopus
Match: mettl16 (methyltransferase like 16 [Source:Xenbase;Acc:XB-GENE-952802]) HSP 1 Score: 460.685 bits (1184), Expect = 7.551e-159 Identity = 233/429 (54.31%), Postives = 299/429 (69.70%), Query Frame = 3
Query: 138 CFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
C +A + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L P+WKKAATALKGVVK+GAV+ D++ SLG YG++GFPTIK+FG +K+ P DYQG RTA +I++AAL L V+ RLGG SGGS S + G DV++LTD FD+ VL S++ W VEF+APWCGHCKNL+P W AA+E++ GKVKL A+DATV ASRYG++G+PTIK F G D DYDGGR+ +DIV A D E P PEI EILN +I+K C++HQLC+VAVLP+ILD + RN Y+ + DKYK WGWLW EA +LE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGSTS + G +P I +V PWDGKDGE+P E++IDLS++ +++
Sbjct: 6 CTLFMAASAMYSPSDDVIELTPSNFNKEVIQSDSLWLVEFYAPWCGHCQRLTPDWKKAATALKGVVKIGAVNADQHQSLGGQYGVRGFPTIKVFGANKNKPDDYQGGRTADAIIDAALSSLRSFVKDRLGGRSGGSDSGRQVGFSGYIKK--DVIDLTDDTFDKNVLNSDDVWFVEFYAPWCGHCKNLEPEWAAAATEIKQQTNGKVKLAAVDATVSQVLASRYGIRGFPTIKIFQKG---EDPVDYDGGRTKADIVARAIDLFSENAPPPEIYEILNGDIVKKTCDEHQLCIVAVLPHILDTGASGRNSYLDVMMKMADKYKKKMWGWLWAEAGAQMDLETSLGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTSPVGGGAIPKINTVVPWDGKDGELPAEDDIDLSDVELDD 429
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Mouse
Match: Pdia6 (protein disulfide isomerase associated 6 [Source:MGI Symbol;Acc:MGI:1919103]) HSP 1 Score: 468.003 bits (1203), Expect = 1.149e-161 Identity = 245/444 (55.18%), Postives = 308/444 (69.37%), Query Frame = 3
Query: 111 MKYLSIVLFCFALAQCNADI------TEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
M+ + + L C + + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAATALK VVKVGAV+ DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ SS DVVELTD FD+ VL SE+ W+VEF+APWCGHCKNL+P W AA+E++ GKVKL A+DAT++ ASRYG++G+PTIK F G DYDGGR+ SDIV A D + P PE+ EI+N++I K CE+HQLCVVAVLP+ILD + RN Y+ L DKYK WGWLWTEA ELEN GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G PTI EPWDGKDGE+P E++IDLS++ +++
Sbjct: 1 MRVIGMARLVLGLVSCTFFLAVSGLYSSSDDVIELTPSNFNREVIQSDGLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKK--DVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATMNQVLASRYGIKGFPTIKIFQKGESP---VDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGSFPTITPREPWDGKDGELPVEDDIDLSDVELDD 439
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Mouse
Match: Pdia4 (protein disulfide isomerase associated 4 [Source:MGI Symbol;Acc:MGI:104864]) HSP 1 Score: 154.066 bits (388), Expect = 8.603e-40 Identity = 107/306 (34.97%), Postives = 150/306 (49.02%), Query Frame = 3
Query: 183 GVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKG---VVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVL------PNIL---DCQSQCRNDY 1055
GV VL + NF+ + VL+EFYAPWCGHC+ APE++K A+ LK + V +D S L + + G+PTIKI K + DY G RT IV A ++E+ + + + LT NFD+ V+ + + LVEF+APWCGHCK L P +++AA EL + + L +DAT T A R+ V GYPT+K F + G DY+G R IV D ++EQ P KEIL + ++ +D V+ L P L D + R DY
Sbjct: 59 GVWVLNDGNFDNFVADKDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIAVAKIDATSASMLASKFDVSGYPTIKILKKGQAV--DYDGSRTQEEIV-AKVREVSQ---------------------PDWTPPPEVTLSLTKDNFDD-VVNNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLAKRFDVSGYPTLKIF----RKGRPFDYNGPREKYGIV----DYMIEQ-SGPPSKEILTLKQVQEFLKDGDDVVIIGLFQGDGDPAYLQYQDAANNLREDY 330 HSP 2 Score: 90.1225 bits (222), Expect = 1.372e-18 Identity = 44/108 (40.74%), Postives = 65/108 (60.19%), Query Frame = 3
Query: 180 EGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV---VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKE 494
E L LT NF++V+ +LVEFYAPWCGHC+ LAPE++KAA L + + VD + + L + + + G+PT+KIF K + P DY G R IV+ +++
Sbjct: 173 EVTLSLTKDNFDDVVNNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLAKRFDVSGYPTLKIFRKGR--PFDYNGPREKYGIVDYMIEQ 278 HSP 3 Score: 88.9669 bits (219), Expect = 3.695e-18 Identity = 68/227 (29.96%), Postives = 107/227 (47.14%), Query Frame = 3
Query: 603 LTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQ---LPAPEIKEILNQEILKSACEDHQLCVVAVL-PNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFV 1262
L D NFD V ++ L+EF+APWCGHCK P +++ AS L+ + + +DAT + AS++ V GYPTIK +K G + DYDG R+ +IV A + V Q P PE+ L ++ + + +V P C+ A +++ +S +A + +L F + GYP L + RK + GP + GI D++
Sbjct: 63 LNDGNFDNFVA-DKDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIAVAKIDATSASMLASKFDVSGYPTIKI----LKKGQAVDYDGSRTQEEIV--AKVREVSQPDWTPPPEVTLSLTKDNFDDVVNNADIILVEFYAPWCGHCKKLAPEYEKAAKELSK---RSPPIPLAKVDATEQTDLAKRFDVS--GYPTLKI--FRKGRPFDYNGPREKYGIVDYM 275 HSP 4 Score: 73.1738 bits (178), Expect = 3.858e-13 Identity = 34/105 (32.38%), Postives = 58/105 (55.24%), Query Frame = 3
Query: 615 NFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKL--GALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQ 923
FD +V+ ++ L+EF+APWCGHCK L+P + + +G+ L +DAT + T +Y V+G+PTI F P+G K + G R + ++ + ++
Sbjct: 530 TFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGKKYKGQKDLVIAKMDATANDITNDQYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHATKR 634 HSP 5 Score: 56.9954 bits (136), Expect = 5.077e-8 Identity = 33/94 (35.11%), Postives = 49/94 (52.13%), Query Frame = 3
Query: 186 VLVLTNSNFNEVI-EKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSS--LGQPYGIQGFPTIKIFGKS--KHSPKDYQG 452
V V+ F+ ++ + K VL+EFYAPWCGHC+ L P + KG + MD ++ Y ++GFPTI F S K +P ++G
Sbjct: 523 VKVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGKKYKGQKDLVIAKMDATANDITNDQYKVEGFPTI-YFAPSGDKKNPIKFEG 615
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Mouse
Match: Dnajc10 (DnaJ heat shock protein family (Hsp40) member C10 [Source:MGI Symbol;Acc:MGI:1914111]) HSP 1 Score: 130.183 bits (326), Expect = 1.906e-31 Identity = 67/222 (30.18%), Postives = 111/222 (50.00%), Query Frame = 3
Query: 183 GVLVLTNSNFNEVIEKNKYV---LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQG----ERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFF 827
V+ LT S FNE++++ K+ +V+FY+PWC CQ L PEWK+ A L G++ VG+VD +Y S +Q +P I+ + + Y R A S+ + L L + ++LT F+E VL+ + W+V+F+APWCG C+N P ++ A ++GKV+ G +D + T + G++ YP++K +
Sbjct: 557 SVVSLTPSTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQKSSKAYQYHSYNGWNRDAYSLRSWGLGFLPQAS-----------------------------IDLTPQTFNEKVLQGKTHWVVDFYAPWCGPCQNFAPEFELLARMIKGKVRAGKVDCQAYPQTCQKAGIKAYPSVKLY 749 HSP 2 Score: 124.79 bits (312), Expect = 1.259e-29 Identity = 73/223 (32.74%), Postives = 114/223 (51.12%), Query Frame = 3
Query: 243 LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMV--LKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPA-GVKSGDSQDYDG-GRSSSDIVRW 899
LV+F+APWC C++L PE +KA+T L G +KVG +D + L Y IQ +PT +F +S S +Y+G +A I+ E E +R+ VV LT S F+E+V K +E W+V+F++PWC C+ L P W + A L G + +G++D + + ++ VQ YP I+F+P K+ Y+G R + + W
Sbjct: 472 LVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVFNQS--SIHEYEGHHSAEQIL-----EFIEDLRN------------------------PSVVSLTPSTFNELVKQRKHDEVWMVDFYSPWCHPCQVLMPEWKRMARTLTGLINVGSVDCQQYHSFCTQENVQRYPEIRFYPQKSSKAYQYHSYNGWNRDAYSLRSW 663 HSP 3 Score: 77.0258 bits (188), Expect = 2.543e-14 Identity = 34/89 (38.20%), Postives = 51/89 (57.30%), Query Frame = 3
Query: 642 EEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASD 908
+EPWLV+FFAPWC C+ L P +A++ L G++K+G LD T+H + Y +Q YPT F +Y+G S+ I+ + D
Sbjct: 468 KEPWLVDFFAPWCPPCRALLPELRKASTLLYGQLKVGTLDCTIHEGLCNMYNIQAYPTTVVF----NQSSIHEYEGHHSAEQILEFIED 552 HSP 4 Score: 72.0182 bits (175), Expect = 9.696e-13 Identity = 38/94 (40.43%), Postives = 53/94 (56.38%), Query Frame = 3
Query: 195 LTNSNFNE-VIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSI 473
LT FNE V++ + +V+FYAPWCG CQ+ APE++ A +KG V+ G VD Y Q GI+ +P++K+ YQ ER SI
Sbjct: 675 LTPQTFNEKVLQGKTHWVVDFYAPWCGPCQNFAPEFELLARMIKGKVRAGKVDCQAYPQTCQKAGIKAYPSVKL----------YQYERAKKSI 758 HSP 5 Score: 67.781 bits (164), Expect = 2.250e-11 Identity = 31/108 (28.70%), Postives = 58/108 (53.70%), Query Frame = 3
Query: 186 VLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELV 509
++ L F+ + + V FY+P C HC LAP W++ A + G++++GAV+ L + G+ +P++ IF +S + Y G+R+ S+V A++ + V
Sbjct: 131 IITLERREFDAAVNSGELWFVNFYSPGCSHCHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIF-RSGMAAVKYNGDRSKESLVAFAMQHVRSTV 237 HSP 6 Score: 65.4698 bits (158), Expect = 1.231e-10 Identity = 34/108 (31.48%), Postives = 55/108 (50.93%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKV 914
+++ L FD V S E W V F++P C HC +L P W + A E+ G +++GA++ GV YP++ F +G+ + Y+G RS +V +A V
Sbjct: 130 EIITLERREFDAAV-NSGELWFVNFYSPGCSHCHDLAPTWREFAKEVDGLLRIGAVNCGDDRMLCRMKGVNSYPSLFIFRSGMA---AVKYNGDRSKESLVAFAMQHV 233
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Mouse
Match: Txndc5 (thioredoxin domain containing 5 [Source:MGI Symbol;Acc:MGI:2145316]) HSP 1 Score: 121.324 bits (303), Expect = 3.951e-30 Identity = 79/259 (30.50%), Postives = 140/259 (54.05%), Query Frame = 3
Query: 177 EEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKG--VVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXX----DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQ-AASELRG--KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRS----SSDIVRWASDKV 914
++G+ L+ +NF + + + ++F+APWCGHC++LAP W++ A L+ VK+G VD ++ ++ + ++G+PT+ F K + Y+G+R L+ L + V+S+L G+ + E + + V+ LT+ +F++ + + V+F+APWCGHCKNL P W++ + E G V + +D T S+Y V+GYPT+ F G K G +++GGR S ++R A D++
Sbjct: 80 KQGLYELSANNFELHVSQGNH-FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKVDQ-YKGKRD--------LESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDKGTVLALTEKSFEDTIAQGIT--FVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEVDCTAERNVCSKYSVRGYPTLLLFRGGEKVG---EHNGGRDLDSLHSFVLRQAKDEL 323 HSP 2 Score: 88.9669 bits (219), Expect = 6.343e-19 Identity = 65/208 (31.25%), Postives = 97/208 (46.63%), Query Frame = 3
Query: 330 VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK--VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKE 947
V V VD S + G++G+PT+K F + + K YQG R ++ N L+ L+E ++ + + EL+ +NF+ V S+ ++FFAPWCGHCK L P W+Q A L VK+G +D T H A S + V+GYPT+ +F G K Y G R + + ++ APE E
Sbjct: 6 VYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVK-YQGPRDFETLENWMLQTLNE----------EPATPEPEAEPPRAPELKQGLYELSANNFELHV--SQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKK---VDQYKGKRDLESLRDYVQSQLQGSEAAPETVE 197
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Mouse
Match: Txndc5 (thioredoxin domain containing 5 [Source:MGI Symbol;Acc:MGI:2145316]) HSP 1 Score: 121.324 bits (303), Expect = 5.830e-30 Identity = 79/259 (30.50%), Postives = 140/259 (54.05%), Query Frame = 3
Query: 177 EEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKG--VVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXX----DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQ-AASELRG--KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRS----SSDIVRWASDKV 914
++G+ L+ +NF + + + ++F+APWCGHC++LAP W++ A L+ VK+G VD ++ ++ + ++G+PT+ F K + Y+G+R L+ L + V+S+L G+ + E + + V+ LT+ +F++ + + V+F+APWCGHCKNL P W++ + E G V + +D T S+Y V+GYPT+ F G K G +++GGR S ++R A D++
Sbjct: 101 KQGLYELSANNFELHVSQGNH-FIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKKVDQ-YKGKRD--------LESLRDYVQSQLQGSEAAPETVEPSEAPVMAAEPTGDKGTVLALTEKSFEDTIAQGIT--FVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVTIAEVDCTAERNVCSKYSVRGYPTLLLFRGGEKVG---EHNGGRDLDSLHSFVLRQAKDEL 344 HSP 2 Score: 103.219 bits (256), Expect = 1.016e-23 Identity = 74/233 (31.76%), Postives = 107/233 (45.92%), Query Frame = 3
Query: 267 CGHCQSLAPEWK----KAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK--VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKE 947
CGHCQ L P W K + V V VD S + G++G+PT+K F + + K YQG R ++ N L+ L+E ++ + + EL+ +NF+ V S+ ++FFAPWCGHCK L P W+Q A L VK+G +D T H A S + V+GYPT+ +F G K Y G R + + ++ APE E
Sbjct: 2 CGHCQRLQPTWNDLGDKYNSMEDAKVYVAKVDCTADSDVCSAQGVRGYPTLKFFKPGQEAVK-YQGPRDFETLENWMLQTLNE----------EPATPEPEAEPPRAPELKQGLYELSANNFELHV--SQGNHFIKFFAPWCGHCKALAPTWEQLALGLEHSETVKIGKVDCTQHYAVCSEHQVRGYPTLLWFRDGKK---VDQYKGKRDLESLRDYVQSQLQGSEAAPETVE 218 HSP 3 Score: 62.003 bits (149), Expect = 6.559e-10 Identity = 41/121 (33.88%), Postives = 65/121 (53.72%), Query Frame = 3
Query: 162 ADITEEEG-VLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEW----KKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKEL-DEL 506
A+ T ++G VL LT +F + I + V+FYAPWCGHC++LAP W KK L V + VD ++ Y ++G+PT+ +F + ++ G R S+ + L++ DEL
Sbjct: 227 AEPTGDKGTVLALTEKSFEDTIAQG-ITFVKFYAPWCGHCKNLAPTWEELSKKEFPGLSDVT-IAEVDCTAERNVCSKYSVRGYPTLLLF-RGGEKVGEHNGGRDLDSLHSFVLRQAKDEL 344
BLAST of Protein disulfide-isomerase A6 vs. UniProt/SwissProt
Match: sp|Q11067|PDIA6_CAEEL (Protein disulfide-isomerase A6 homolog OS=Caenorhabditis elegans OX=6239 GN=pdi-6 PE=3 SV=1) HSP 1 Score: 475.322 bits (1222), Expect = 8.730e-164 Identity = 230/425 (54.12%), Postives = 306/425 (72.00%), Query Frame = 3
Query: 111 MKYLSIVLFCFALAQCNADITEEEGVLVLTNSNF-NEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXX---XDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKE 1373
M + ++L A+ ++++ V+ LT +NF ++VI + +VEFYAPWCGHC+SL PE+KKAA+ALKGV KVGAVDM ++ S+G PY +QGFPT+KIFG K P DY G+RTA +I ++ L E + V +RLGG S GSSS S G G G +VVELTD+NF+++VL S++ WLVEFFAPWCGHCK+L+P W AASEL+GKV+LGALDATVHT A+++ ++G+PTIK+F G D+QDYDGGR SSDIV WAS + E +PAPE+ E +NQ++++ AC++ QLC+ A LP+ILDCQS+CRN+Y+A LK +K+K N WGW+W E P LE F +GGFGYPA+ +N RK KYA L G F + GI +F+RD+S G+G TS + GDG P I+ E WDGKDG +P E
Sbjct: 1 MALIKLLLASLAITSVCGMYSKKDDVVELTEANFQSKVINSDDIWIVEFYAPWCGHCKSLVPEYKKAASALKGVAKVGAVDMTQHQSVGGPYNVQGFPTLKIFGADKKKPTDYNGQRTAQAIADSVLAEAKKAVSARLGGKSSGSSSSGSGSGSGKRGGGGSGNEVVELTDANFEDLVLNSKDIWLVEFFAPWCGHCKSLEPQWKAAASELKGKVRLGALDATVHTVVANKFAIRGFPTIKYFAPGSDVSDAQDYDGGRQSSDIVAWASARAQENMPAPEVFEGINQQVVEDACKEKQLCIFAFLPHILDCQSECRNNYLAMLKEQSEKFKKNLWGWIWVEGAAQPALEESFEVGGFGYPAMTALNFRKNKYAVLKGSFGKDGIHEFLRDLSYGKGRTSSLRGDGFPKIQKTEKWDGKDGALPAE 425
BLAST of Protein disulfide-isomerase A6 vs. UniProt/SwissProt
Match: sp|Q15084|PDIA6_HUMAN (Protein disulfide-isomerase A6 OS=Homo sapiens OX=9606 GN=PDIA6 PE=1 SV=1) HSP 1 Score: 471.085 bits (1211), Expect = 3.141e-162 Identity = 249/435 (57.24%), Postives = 309/435 (71.03%), Query Frame = 3
Query: 120 LSIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
L +V F LA N + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAATALK VVKVGAVD DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ S SS DV+ELTD +FD+ VL SE+ W+VEF+APWCGHCKNL+P W AASE++ GKVKL A+DATV+ ASRYG++G+PTIK F G DYDGGR+ SDIV A D + P PE+ EI+N++I K CE+HQLCVVAVLP+ILD + RN Y+ L DKYK WGWLWTEA ELE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G PTI EPWDG+DGE+P E++IDLS++ +++
Sbjct: 6 LGLVSCTFFLA-VNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKK--DVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESP---VDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDD 434
BLAST of Protein disulfide-isomerase A6 vs. UniProt/SwissProt
Match: sp|Q5R6T1|PDIA6_PONAB (Protein disulfide-isomerase A6 OS=Pongo abelii OX=9601 GN=PDIA6 PE=2 SV=1) HSP 1 Score: 468.003 bits (1203), Expect = 5.504e-161 Identity = 243/429 (56.64%), Postives = 305/429 (71.10%), Query Frame = 3
Query: 138 CFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
C + N + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAATALK VVKVGAVD DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ S SS DV+ELTD +FD+ VL SE+ W+VEF+APWCGHCKNL+P W AASE++ GKVKL A+DATV+ ASRYG++G+PTIK F G DYDGGR+ SDIV A D + P PE+ EI++++I K CE+HQLCVV+VLP+ILD + RN Y+ L DKYK WGWLWTEA ELE GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G PTI EPWDG+DGE+P E++IDLS++ +++
Sbjct: 11 CAFFLEVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGQSGGYSSGKQGRSDSSSKK--DVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESP---VDYDGGRTRSDIVSRALDLFSDNAPPPELLEIISEDIAKRTCEEHQLCVVSVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDD 434
BLAST of Protein disulfide-isomerase A6 vs. UniProt/SwissProt
Match: sp|Q922R8|PDIA6_MOUSE (Protein disulfide-isomerase A6 OS=Mus musculus OX=10090 GN=Pdia6 PE=1 SV=3) HSP 1 Score: 467.618 bits (1202), Expect = 7.798e-161 Identity = 248/435 (57.01%), Postives = 308/435 (70.80%), Query Frame = 3
Query: 120 LSIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
L +V F LA + + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAATALK VVKVGAV+ DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ SS DVVELTD FD+ VL SE+ W+VEF+APWCGHCKNL+P W AA+E++ GKVKL A+DATV+ ASRYG++G+PTIK F G DYDGGR+ SDIV A D + P PE+ EI+N++I K CE+HQLCVVAVLP+ILD + RN Y+ L DKYK WGWLWTEA ELEN GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G PTI EPWDGKDGE+P E++IDLS++ +++
Sbjct: 6 LGLVSCTFFLA-VSGLYSSSDDVIELTPSNFNREVIQSDGLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKK--DVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESP---VDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGSFPTITPREPWDGKDGELPVEDDIDLSDVELDD 434
BLAST of Protein disulfide-isomerase A6 vs. UniProt/SwissProt
Match: sp|Q63081|PDIA6_RAT (Protein disulfide-isomerase A6 OS=Rattus norvegicus OX=10116 GN=Pdia6 PE=1 SV=2) HSP 1 Score: 467.233 bits (1201), Expect = 1.315e-160 Identity = 247/435 (56.78%), Postives = 308/435 (70.80%), Query Frame = 3
Query: 120 LSIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
L +V F LA +A + + V+ LT SNFN EVI+ + LVEFYAPWCGHCQ L PEWKKAA+ALK VVKVGAV+ DK+ SLG YG+QGFPTIKIFG +K+ P+DYQG RT +IV+AAL L +LV+ RLGG SGG SS ++ SS DVVELTD FD+ VL SE+ W+VEF+APWCGHCKNL+P W AA+E++ GKVKL A+DATV+ ASRYG++G+PTIK F G DYDGGR+ SDIV A D + P PE+ EI+N++I K CE+HQLCVVAVLP+ILD + RN Y+ L DKYK WGWLWTEA ELEN GIGGFGYPA+ +N RKMK+A L G FS+ GI +F+R++S GRGST+ + G P I EPWDGKDGE+P E++IDLS++ +++
Sbjct: 6 LGLVSCTFFLA-VSALYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAASALKDVVKVGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKK--DVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESP---VDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGATGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGSFPNITPREPWDGKDGELPVEDDIDLSDVELDD 434
BLAST of Protein disulfide-isomerase A6 vs. TrEMBL
Match: A0A1S3JU63 (protein disulfide-isomerase A6 homolog isoform X1 OS=Lingula unguis OX=7574 GN=LOC106175982 PE=3 SV=1) HSP 1 Score: 551.977 bits (1421), Expect = 0.000e+0 Identity = 265/433 (61.20%), Postives = 337/433 (77.83%), Query Frame = 3
Query: 111 MKYLSIVLFCFALAQCNADITEEEGVLVLTNSNFNE-VIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIE 1406
M+ ++ +L C ++ +A + + V+ LT +NFN+ VI+ ++ LVEFYAPWCGHCQSLAPEWKKAATALKGVV VGAVDMD++ S+G PYGI+GFPTIKIFG +K+ +DY G R+A +IV++A+ L ++V++RL G G S G G V+ELTDSNF+E+VL SE+ WLVEFFAPWCGHCKNL PHW+QAASEL+GKVKLGALDATVHT A+RYGV+GYPTIK FPAG K GD+ +YDGGR++SDIVRWASD++VE LP PEI +I ++ LK ACEDH LC++AVLP+ILDCQS+CRN Y+ +K GDKYK +WGW+W EAM+ PELE+ GIGGFGYPA+ +N RKMKYA L G FS+ GI F+R++S+GRGSTS + LP IK V+PWDGKDG++ EEEIDLS++ +E
Sbjct: 1 MQAIAGLLICGLISVTSALYSSSDDVIELTAANFNQKVIQSDQLWLVEFYAPWCGHCQSLAPEWKKAATALKGVVNVGAVDMDQHQSVGGPYGIRGFPTIKIFGANKNKAEDYNGARSANAIVDSAMSHLKQMVQARLSGRGGSSGGGRSSGGGSQGGGKA-VIELTDSNFEELVLNSEDFWLVEFFAPWCGHCKNLAPHWEQAASELKGKVKLGALDATVHTVMANRYGVRGYPTIKAFPAGKKDGDTIEYDGGRTASDIVRWASDRIVENLPPPEIVQITEEKSLKDACEDHPLCIIAVLPHILDCQSECRNKYLDVMKELGDKYKGKQWGWVWAEAMQQPELEDSLGIGGFGYPAMAAMNARKMKYAILRGAFSKDGINSFLRELSVGRGSTSPVKNAQLPPIKKVDPWDGKDGKLEVEEEIDLSDVELE 432
BLAST of Protein disulfide-isomerase A6 vs. TrEMBL
Match: F1KYD8 (Protein disulfide-isomerase A6 OS=Ascaris suum OX=6253 PE=2 SV=1) HSP 1 Score: 519.62 bits (1337), Expect = 8.782e-179 Identity = 244/431 (56.61%), Postives = 324/431 (75.17%), Query Frame = 3
Query: 120 LSIVLFCFALAQCNADITEEEGVLVLTNSNF-NEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
L+ V + C+A V+ LT SNF N V+ ++ +VEFYAPWCGHC++ APE+KKAA ALKG++KVGAVDM ++ S+GQPY +QGFPT+KIFG +K P DYQG RTA + +AA++EL V +RLGG + S ++ + G +V+ELTDSNFDE+VL S++ W+VEFFAPWCGHCK LKPHWDQAA+EL+GK+KLGALDATVH ASR+G++G+PTIK+F G + D+ DYDGGRSSSDIV+WA +K E +PAPEI E +Q I++ AC++ QLC+V+VLP+ILDCQS+CRNDY+A LK G+K+K N WGW+WTEA K PELE FG+GGFGYPA+ VN RKMK++ L G F + GI +F+RD+S G+G T+ + G P I+ VEPWDGKDG +P +EEID+S++ +++
Sbjct: 3 LAFVYLVVGASVCSALYDGNTDVIELTQSNFHNRVLNSDEIWIVEFYAPWCGHCKNFAPEYKKAAKALKGLIKVGAVDMTEHQSVGQPYNVQGFPTVKIFGANKQKPSDYQGARTAQGLADAAIEELRRTVSARLGGKTSTGSGGKKSTGGDGK----EVIELTDSNFDELVLHSKDAWMVEFFAPWCGHCKALKPHWDQAATELKGKIKLGALDATVHQVMASRFGIKGFPTIKYFAPGSGADDAVDYDGGRSSSDIVQWALNKAAENMPAPEIMEATSQPIVEEACKEKQLCIVSVLPDILDCQSKCRNDYLAVLKELGEKFKKNMWGWIWTEAGKQPELEEAFGMGGFGYPAMAAVNYRKMKFSMLKGSFGKDGINEFLRDLSYGKGQTAPVKGAEFPKIRKVEPWDGKDGVMPVDEEIDISDVELDD 429
BLAST of Protein disulfide-isomerase A6 vs. TrEMBL
Match: A0A0N4V5W5 (Uncharacterized protein OS=Enterobius vermicularis OX=51028 GN=EVEC_LOCUS5245 PE=3 SV=1) HSP 1 Score: 517.309 bits (1331), Expect = 6.502e-178 Identity = 247/430 (57.44%), Postives = 326/430 (75.81%), Query Frame = 3
Query: 135 FCFALAQCNADITEEEGVLVLTNSNF-NEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEEPKSE 1421
F NA ++ V+ LT SNF N VI+ ++ +VEF+APWCGHC++LAPE+KKAA ALKG++KVGAVDM ++ ++GQPY ++GFPTIKIFG K P DYQG RTA +IV+AA+ EL + RLGG +G S + GS+ DV+ELTDSNF+ MVL S++ WLVEFFAPWCGHCKNLKPHW+QAA+EL+GKVKLGALDAT H AS++G++G+PTIK+F G + D+ DYDGGR+SSDIV+WA +KV E +PAPE+ E +QE+++ AC++ QLCV++VLP+ILDCQS+CRNDYI LK +K+K N WGW+WTEA K P LE FG+GGFGYPA+ +N RKMK+A L G FS+ GI +F+RD+S G+G T+ + G P +K VEPWDGKDGE+P +E+IDLS++ +E+ + E
Sbjct: 1 MAFISTSVNALYDSQDEVVELTASNFQNRVIKGDEIWVVEFFAPWCGHCKNLAPEYKKAAKALKGLIKVGAVDMTQHQAVGQPYNVRGFPTIKIFGGDKQKPSDYQGARTAQAIVDAAINELKKTASVRLGGKTGSGESKKGSGKRGSAD---DVIELTDSNFESMVLNSDDIWLVEFFAPWCGHCKNLKPHWEQAAAELKGKVKLGALDATTHQVMASKFGIKGFPTIKYFAPGSSADDAVDYDGGRTSSDIVQWALNKVAENVPAPEVVEATSQEVVEKACKEAQLCVISVLPHILDCQSKCRNDYIQILKELAEKFKRNLWGWVWTEAGKQPALEEAFGMGGFGYPAMAALNYRKMKFAMLKGSFSKDGIHEFLRDLSYGKGQTAPVKGAEFPKLKKVEPWDGKDGEMPVDEDIDLSDVELEDLEPE 427
BLAST of Protein disulfide-isomerase A6 vs. TrEMBL
Match: A0A0B2W322 (Uncharacterized protein OS=Toxocara canis OX=6265 GN=tag-320 PE=3 SV=1) HSP 1 Score: 516.153 bits (1328), Expect = 1.665e-177 Identity = 245/440 (55.68%), Postives = 328/440 (74.55%), Query Frame = 3
Query: 117 YLSIVLFCFALAQCNADITEEEGVLVLTNSNF-NEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE---PKSEL 1424
+LS++ +++ C A V+ LT SNF N+V+ ++ +VEFYAPWCGHC++ APE+KKAA LKG++KVGAVDM + S+GQPY +QGFPT+KIFG +K P +YQG RTA + +A ++EL +V +RLGG S S ++ G V+ELTDSNFDE+VL S++ W+VEF+APWCGHCK LKPHWD+AA+EL+GKVKLGALDATVH ASR+G++G+PTIK+F G S D+ DYDGGRSSSDIV+WA +K E +PAPEI E +Q ++ AC++ QLC+VAVLP+ILDCQS+CRNDY+A LK G+K+K N WGW+WTEA K P+LE FG+GGFGYPA+ VN RKMK++ L G F + GI +F+RD+S G+G T+ + G +P I+ VEPWDGKDG +P +EEID+S++ +E+ K+EL
Sbjct: 2 WLSLLFIVVSVSACTALYDGSTDVVELTQSNFHNKVLNSDELWIVEFYAPWCGHCKNFAPEYKKAAKVLKGLIKVGAVDMTVHQSVGQPYNVQGFPTVKIFGANKQKPTEYQGARTAQGLADAGIEELRRMVSARLGGRSSDGSGGKKSGGGDGKD----VIELTDSNFDELVLHSKDAWMVEFYAPWCGHCKALKPHWDEAATELKGKVKLGALDATVHQVMASRFGIKGFPTIKYFAPGSGSDDAVDYDGGRSSSDIVQWALNKAAENMPAPEIMEATSQSVVVEACKEKQLCIVAVLPDILDCQSKCRNDYLAVLKELGEKFKKNMWGWIWTEAGKQPDLEEAFGMGGFGYPAMAAVNYRKMKFSMLKGSFGKDGINEFLRDLSYGKGQTAPVKGAEIPKIRDVEPWDGKDGVMPVDEEIDVSDVDLEDLNTAKTEL 437
BLAST of Protein disulfide-isomerase A6 vs. TrEMBL
Match: A0A267EG43 (Uncharacterized protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig030607g1 PE=3 SV=1) HSP 1 Score: 516.153 bits (1328), Expect = 6.422e-177 Identity = 254/441 (57.60%), Postives = 320/441 (72.56%), Query Frame = 3
Query: 111 MKYLSIVLFCFALAQCNADITEE-EGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKL-PELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEEPKSEL 1424
MK L ALA + + + V+ LT +NFN +V+ ++ LVEFYAPWCGHCQSLAP WK+AA ALKGVVKVGA++MD++ S+GQPYGI+GFPTIK+FG K SP DY G R+A SIV+ AL L +VR RL G SG + DV+ELTD+NF+ V+ S++ WLVEFFAPWCGHCK LKPHWD+AASEL GKVKLGALDATVHT+ A+RYG+QGYPTIK FPAG K+G++ +YDGGR+S DIVRWA DK+ + + PEI EI +Q +L+ C D QLCVV+VLP +LDCQS CRN Y+ LK G+KYK WGW+W + + +LE FGIGGFGYPA+ VVN +KMK++ L GPF+ GI +FVR +SLGRGST + G +P K +PWDGKD +I +++EIDLSELG+E K+EL
Sbjct: 40 MKAAFAFLCGLALASSTLALYDSSDDVIELTTANFNSKVLNSDELWLVEFYAPWCGHCQSLAPAWKQAARALKGVVKVGAINMDEHQSVGQPYGIRGFPTIKVFGSDKQSPSDYNGARSADSIVDTALSHLQAMVRQRLSGGGSSRGGSGGGGSGSGA----DVIELTDANFESTVMGSKDLWLVEFFAPWCGHCKQLKPHWDRAASELSGKVKLGALDATVHTSMAARYGIQGYPTIKMFPAGRKTGEAVEYDGGRTSDDIVRWALDKLADSIAPPEIVEITDQTVLQDHCLDKQLCVVSVLPQLLDCQSDCRNGYLKILKEIGEKYKKLMWGWVWFQGGDMQTQLEEAFGIGGFGYPAMAVVNAKKMKFSLLKGPFTFDGINEFVRSLSLGRGSTEPVRGASIPEAKKRDPWDGKDAKITQDDEIDLSELGMES-KTEL 475
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Cavefish
Match: PDIA6 (protein disulfide-isomerase A6 [Source:NCBI gene;Acc:103027650]) HSP 1 Score: 459.914 bits (1182), Expect = 8.435e-159 Identity = 226/427 (52.93%), Postives = 297/427 (69.56%), Query Frame = 3
Query: 111 MKYLSIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAAS----ELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEE 1376
M+ L VL + + T + V+ L SNFN +V++ + L+EFYAPWCGHCQ L P+WKKAATALKG+VK+GAVD D++ SLG YGI+GFPTIK+FG +K+ P DYQG RT+ +IV A+ L LV+ RL G +GGS ++ G +G DVVELTD NFD +VL +E W+VEFFAPWCGHCK L+P W AA+ + +GKVKLGA+DATVH ASRYG++G+PTIK F G + +DY+GGR+ +DIV A D P PE+ EI++Q+I KS C+D QLC+VAVLP+ILD + RN Y+ ++ +KYK WGWLW EA +LE+ GIGGFGYPA+ +N RKMKY+ L G FS++GI +F+RD+S+GRGST+ I G LP I +VE W+GKDG++P EE
Sbjct: 1 MELLQGVLVSALVITVHGFYTASDDVIELNPSNFNKQVLQSDSLWLIEFYAPWCGHCQRLTPDWKKAATALKGIVKIGAVDADQHKSLGSQYGIRGFPTIKVFGANKNKPDDYQGGRTSEAIVEGAMTALRSLVKDRLSGRTGGSGQSKQSGGGSGAGDKKDVVELTDDNFDRLVLNGDEVWMVEFFAPWCGHCKRLEPEWTAAATAVKDQTKGKVKLGAVDATVHQGLASRYGIRGFPTIKIFSKGE---EPEDYEGGRTRADIVARAMDLFSANAPPPELHEIIDQDIFKSTCDDSQLCIVAVLPHILDTGASGRNSYLDVMRKMAEKYKKKMWGWLWAEAGAQMDLESSLGIGGFGYPAMAAINARKMKYSLLKGSFSETGIHEFLRDLSVGRGSTASIGGGALPKISTVEAWNGKDGQLPVEE 424
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Cavefish
Match: pdia6 (protein disulfide-isomerase A6-like [Source:NCBI gene;Acc:103041928]) HSP 1 Score: 453.751 bits (1166), Expect = 3.125e-156 Identity = 230/430 (53.49%), Postives = 299/430 (69.53%), Query Frame = 3
Query: 111 MKYLSIVLFC-FALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXX---XXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKE 1373
M+ + VL C + + + + V+ L SNFN EV++ + LVEFYAPWCGHCQSL PEWKKAA+ALKGVVK+GAVD D+++SLG YG++GFPTIKIFG +K+ P++YQG R++ +IV+ AL L +V+ RL G + S G S GS DV+ELTD NFDE V S++ W+VEFFAPWCGHCKNL+P W AAS+++ G+VKLGA+DATVH ASRYG++G+PTIK F G + +DY GGR+ SDI+ A D + P PE+ EILN++ILK C+DHQLCV+AVLP+ILD + RN Y+ + +KYK WGWLWTEA +LE GIGGFGYPA+ +N RKMK+A L G FS++GI +F+RD+S+GRGST+ + G LP I SVE WDGKDG +P E
Sbjct: 1 MRAVLGVLACSLTVLSVHGLYSASDDVIELNPSNFNREVLQSDSLWLVEFYAPWCGHCQSLVPEWKKAASALKGVVKIGAVDADQHNSLGGQYGVRGFPTIKIFGANKNKPEEYQGGRSSQAIVDTALNALRSIVKDRLSGKTGGSDYSRQSSGGGGGSSGGSKQDVIELTDDNFDEKVFGSDDVWMVEFFAPWCGHCKNLEPEWAAAASQVKEQTNGRVKLGAVDATVHQGLASRYGIRGFPTIKVFRKGE---EPEDYQGGRTRSDIIARALDLYSDNAPPPEMLEILNEDILKKTCDDHQLCVIAVLPHILDTGAAGRNGYLEVMMKMAEKYKKKMWGWLWTEAGAQMDLEASLGIGGFGYPAMAAINARKMKFALLKGSFSETGIHEFLRDLSVGRGSTATVGGGALPKINSVEAWDGKDGVLPVE 427
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Cavefish
Match: pdia4 (protein disulfide isomerase family A member 4 [Source:NCBI gene;Acc:103026638]) HSP 1 Score: 167.933 bits (424), Expect = 9.530e-45 Identity = 103/277 (37.18%), Postives = 152/277 (54.87%), Query Frame = 3
Query: 162 ADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV---VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILN-QEILK 971
++ EE GVLVLT++NF+ +E VLVEFYAPWCGHC+ APE++K A LK + V VD K ++LG + + G+PTIKI K + P +Y G+R+ +IV + + E+ + + LT NFD+ V+ + + LVEF+APWCGHCK L P +++AA EL + + L +DATV ASR+ V GYPT+K F + G DY+G R IV + S++ P+ +++ + QE+LK
Sbjct: 55 TEVKEENGVLVLTDANFDTFMEGKDTVLVEFYAPWCGHCKQFAPEYEKIAQVLKESDPPIPVAKVDATKATALGSRFEVSGYPTIKILKKGE--PVEYDGDRSEKAIV----ERVKEVAQPDWKPPPEA------------------TLVLTKDNFDD-VVNNADIILVEFYAPWCGHCKRLAPEYEKAAKELSNRTPPILLAKVDATVENDLASRFDVTGYPTLKMF----RKGKVFDYNGPREKIGIVDYMSEQA--GPPSKQVQALKQIQELLK 300 HSP 2 Score: 71.2478 bits (173), Expect = 1.155e-12 Identity = 34/91 (37.36%), Postives = 53/91 (58.24%), Query Frame = 3
Query: 615 NFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKL--GALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSS 881
FDE+VL ++ L+EF+APWCGHCK L+P + A + + + L +DAT + Y V+G+PTI F P+ K + ++GG +
Sbjct: 532 TFDEIVLDKKKDVLIEFYAPWCGHCKKLEPDYLALAKKYKNEKNLVIAKMDATANDVPHDSYKVEGFPTIYFAPSNNKQNPIK-FEGGERN 621 HSP 3 Score: 62.3882 bits (150), Expect = 8.198e-10 Identity = 34/93 (36.56%), Postives = 51/93 (54.84%), Query Frame = 3
Query: 186 VLVLTNSNFNE-VIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSS--LGQPYGIQGFPTIKIF-GKSKHSPKDYQG 452
V V+ F+E V++K K VL+EFYAPWCGHC+ L P++ A K + MD ++ Y ++GFPTI +K +P ++G
Sbjct: 525 VKVIVGKTFDEIVLDKKKDVLIEFYAPWCGHCKKLEPDYLALAKKYKNEKNLVIAKMDATANDVPHDSYKVEGFPTIYFAPSNNKQNPIKFEG 617
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Cavefish
Match: dnajc10 (DnaJ heat shock protein family (Hsp40) member C10 [Source:NCBI gene;Acc:103021499]) HSP 1 Score: 140.198 bits (352), Expect = 7.764e-35 Identity = 70/223 (31.39%), Postives = 112/223 (50.22%), Query Frame = 3
Query: 183 GVLVLTNSNFNEVIEKNKYV---LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQG----ERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFP 830
V+ LT F +++++ K +V+FYAPWCG CQ+L PEW++ A L GV+ VG VD K+ SL Q ++ +P I++F ++ + Y R A S+ AL L V+LT +F +L+ +E W+++F+APWCG C++ P ++ A L+G V+ G +D H T G+ YPT++F+P
Sbjct: 560 AVVTLTPDTFQQLVKRRKQTETWVVDFYAPWCGPCQALLPEWRRMARMLSGVINVGTVDCQKHHSLCQSENVRAYPEIRLFPQNSNRRDQYHSYNGWHRDAQSLKTWALSSLPRA-----------------------------SVDLTPEDFKRKILEGKEHWVLDFYAPWCGPCQHFAPEFEILARMLKGTVRAGKVDCQAHYQTCQSAGITAYPTVRFYP 753 HSP 2 Score: 120.553 bits (301), Expect = 2.115e-28 Identity = 73/224 (32.59%), Postives = 105/224 (46.88%), Query Frame = 3
Query: 243 LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMV--LKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDS-QDYDG-GRSSSDIVRWA 902
LV+F+APWC C++L PE +KA+ L G +K G +D + L Y I +PT IF KS S +Y+G +A I L+ + +LV VV LT F ++V K E W+V+F+APWCG C+ L P W + A L G + +G +D H + V+ YP I+ FP D Y+G R + + WA
Sbjct: 475 LVDFFAPWCPPCRALLPELRKASIQLYGQMKFGTLDCTIHEGLCSRYNINAYPTTVIFNKS--SVHEYEGHHSADGI----LEFIQDLVNPA-------------------------VVTLTPDTFQQLVKRRKQTETWVVDFYAPWCGPCQALLPEWRRMARMLSGVINVGTVDCQKHHSLCQSENVRAYPEIRLFPQNSNRRDQYHSYNGWHRDAQSLKTWA 667 HSP 3 Score: 79.7221 bits (195), Expect = 2.761e-15 Identity = 36/91 (39.56%), Postives = 51/91 (56.04%), Query Frame = 3
Query: 642 EEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKV 914
+EPWLV+FFAPWC C+ L P +A+ +L G++K G LD T+H SRY + YPT F +Y+G S+ I+ + D V
Sbjct: 471 KEPWLVDFFAPWCPPCRALLPELRKASIQLYGQMKFGTLDCTIHEGLCSRYNINAYPTTVIF----NKSSVHEYEGHHSADGILEFIQDLV 557 HSP 4 Score: 79.7221 bits (195), Expect = 3.121e-15 Identity = 58/221 (26.24%), Postives = 96/221 (43.44%), Query Frame = 3
Query: 174 EEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAG 836
E+ ++ L +F+ + + V FY P C HC LAP W++ A + GV+++ AV+ + L + GI +P++ IF ++ +P+ Y GER+ S+ A++ + V + G+V D F E + WL+ F A G C + + A L G VK+G +D T+H + V T FP G
Sbjct: 133 EDPEIITLDRGDFDAAVNSGEVWFVNFYFPRCSHCHDLAPTWREFAKEMDGVIRISAVNCGDNNRLCRSKGISSYPSLFIF-RAGMNPEKYYGERSKHSLTKFAMQYVTSKV---------------------TELWQGNVFTEIDQAFSERI-----GWLITFCAD-TGDCLEAQTR-QKLAGMLDGVVKVGWMDCTLHAELCESFDVTSSST-ALFPPG 323 HSP 5 Score: 65.855 bits (159), Expect = 7.410e-11 Identity = 40/148 (27.03%), Postives = 70/148 (47.30%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPA-------PEIKEILNQEI--LKSACEDHQLCVVA 1007
+++ L +FD V S E W V F+ P C HC +L P W + A E+ G +++ A++ + G+ YP++ F AG+ + + Y G RS + ++A V ++ EI + ++ I L + C D C+ A
Sbjct: 136 EIITLDRGDFDAAV-NSGEVWFVNFYFPRCSHCHDLAPTWREFAKEMDGVIRISAVNCGDNNRLCRSKGISSYPSLFIFRAGM---NPEKYYGERSKHSLTKFAMQYVTSKVTELWQGNVFTEIDQAFSERIGWLITFCADTGDCLEA 279
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Cavefish
Match: dnajc10 (DnaJ heat shock protein family (Hsp40) member C10 [Source:NCBI gene;Acc:103021499]) HSP 1 Score: 139.043 bits (349), Expect = 2.143e-34 Identity = 82/269 (30.48%), Postives = 134/269 (49.81%), Query Frame = 3
Query: 183 GVLVLTNSNFNEVIEKNKYV---LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFP-AGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLP--APEIKEILNQEILK 971
V+ LT F +++++ K +V+FYAPWCG CQ+L PEW++ A L GV+ VG VD K+ SL Q ++ +P I++F ++ + + T + L L L R+ V+LT +F +L+ +E W+++F+APWCG C++ P ++ A L+G V+ G +D H T G+ YPT++F+P G + +Y R S+ I SD + ++L A + K L +ILK
Sbjct: 549 AVVTLTPDTFQQLVKRRKQTETWVVDFYAPWCGPCQALLPEWRRMARMLSGVINVGTVDCQKHHSLCQSENVRAYPEIRLFPQNSNPSSN-----TLNTEYIVILCFLSSLPRAS--------------------------VDLTPEDFKRKILEGKEHWVLDFYAPWCGPCQHFAPEFEILARMLKGTVRAGKVDCQAHYQTCQSAGITAYPTVRFYPYLGTQRVRGGEYINSRDSNVI----SDVIHQRLQQLALKNKSKLKVQILK 782 HSP 2 Score: 117.857 bits (294), Expect = 1.927e-27 Identity = 67/198 (33.84%), Postives = 96/198 (48.48%), Query Frame = 3
Query: 243 LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMV--LKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFP 830
LV+F+APWC C++L PE +KA+ L G +K G +D + L Y I +PT IF KS S +Y+G +A I L+ + +LV VV LT F ++V K E W+V+F+APWCG C+ L P W + A L G + +G +D H + V+ YP I+ FP
Sbjct: 464 LVDFFAPWCPPCRALLPELRKASIQLYGQMKFGTLDCTIHEGLCSRYNINAYPTTVIFNKS--SVHEYEGHHSADGI----LEFIQDLVNP-------------------------AVVTLTPDTFQQLVKRRKQTETWVVDFYAPWCGPCQALLPEWRRMARMLSGVINVGTVDCQKHHSLCQSENVRAYPEIRLFP 630 HSP 3 Score: 80.8777 bits (198), Expect = 1.309e-15 Identity = 36/91 (39.56%), Postives = 51/91 (56.04%), Query Frame = 3
Query: 642 EEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKV 914
+EPWLV+FFAPWC C+ L P +A+ +L G++K G LD T+H SRY + YPT F +Y+G S+ I+ + D V
Sbjct: 460 KEPWLVDFFAPWCPPCRALLPELRKASIQLYGQMKFGTLDCTIHEGLCSRYNINAYPTTVIF----NKSSVHEYEGHHSADGILEFIQDLV 546 HSP 4 Score: 73.1738 bits (178), Expect = 3.452e-13 Identity = 39/134 (29.10%), Postives = 69/134 (51.49%), Query Frame = 3
Query: 114 KYLSIVLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIF---GKSKHSPKDYQGERTAGSIVNAALKELDEL 506
+Y+ I+ F +L + + D+T E+ +++E ++ +++FYAPWCG CQ APE++ A LKG V+ G VD + Q GI +PT++ + G + +Y R + I + + L +L
Sbjct: 643 EYIVILCFLSSLPRASVDLTPEDFK--------RKILEGKEHWVLDFYAPWCGPCQHFAPEFEILARMLKGTVRAGKVDCQAHYQTCQSAGITAYPTVRFYPYLGTQRVRGGEYINSRDSNVISDVIHQRLQQL 768 HSP 5 Score: 72.7886 bits (177), Expect = 4.521e-13 Identity = 32/106 (30.19%), Postives = 59/106 (55.66%), Query Frame = 3
Query: 174 EEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALK 491
E+ ++ L +F+ + + V FY P C HC LAP W++ A + GV+++ AV+ + L + GI +P++ IF ++ +P+ Y GER+ S+ A++
Sbjct: 133 EDPEIITLDRGDFDAAVNSGEVWFVNFYFPRCSHCHDLAPTWREFAKEMDGVIRISAVNCGDNNRLCRSKGISSYPSLFIF-RAGMNPEKYYGERSKHSLTKFAMQ 237 HSP 6 Score: 65.4698 bits (158), Expect = 8.203e-11 Identity = 32/112 (28.57%), Postives = 57/112 (50.89%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQL 926
+++ L +FD V S E W V F+ P C HC +L P W + A E+ G +++ A++ + G+ YP++ F AG+ + + Y G RS + ++A V ++
Sbjct: 136 EIITLDRGDFDAAV-NSGEVWFVNFYFPRCSHCHDLAPTWREFAKEMDGVIRISAVNCGDNNRLCRSKGISSYPSLFIFRAGM---NPEKYYGERSKHSLTKFAMQYVTSKV 243
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Sea Lamprey
Match: pdia6 (protein disulfide isomerase family A, member 6 [Source:ZFIN;Acc:ZDB-GENE-030131-879]) HSP 1 Score: 442.195 bits (1136), Expect = 2.032e-152 Identity = 226/446 (50.67%), Postives = 307/446 (68.83%), Query Frame = 3
Query: 108 KMKYLSIVLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXX-XXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR----GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE-PKSEL 1424
++K ++ +A A + + V+ LT SNFN EV++ N LVEFYAPWCGHCQ L PEWKKAATALKG+VK+GAVD D++ LG Y ++GFPTIKIFG +K+ P+D+ G RT IV+ AL L LV+ RLGG G S + ++ +G V + +++ E W+VEFFAPWCGHCK L+P W AA+E++ G+VKL A+DATV+ ++R+G++G+PTIK F G + Q+Y GGR+ SDIV +A + + PAPE+ EILNQ+++K +CE+HQLC+V++LP+ILD + RN YIATL+ DKYK WGWLWTEA PELE+ GIGGFGYPA+ VN RKMK+A L G FS+SGI +F+R++S+GRGST+ + G LP I S E WDGKDGE+P E++IDLS++ ++E +SEL
Sbjct: 1 EVKVFGALVLGVLVAGAQALYSPSDDVIELTASNFNREVVQSNDLWLVEFYAPWCGHCQRLIPEWKKAATALKGIVKLGAVDADEHKGLGSTYNVRGFPTIKIFGINKNKPEDFNGGRTTQGIVDGALGALRSLVKDRLGGKGGSDSGKQNINTFSGNGFCKRKPVSFSIITTNKITFTPSETWIVEFFAPWCGHCKKLEPEWAAAATEVKAQTNGRVKLAAVDATVNQELSNRFGIRGFPTIKVFRKG--EDEPQEYQGGRTKSDIVAYALELYTDNAPAPEVVEILNQDVVKKSCEEHQLCIVSILPHILDTGATGRNGYIATLQGMADKYKKKLWGWLWTEAGAQPELEDSLGIGGFGYPAMAAVNARKMKFAILKGSFSESGINEFLRELSVGRGSTAPVKGAALPPIISKEAWDGKDGELPVEDDIDLSDVELDEFDRSEL 444
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Sea Lamprey
Match: pdia4 (protein disulfide isomerase family A, member 4 [Source:ZFIN;Acc:ZDB-GENE-030131-5493]) HSP 1 Score: 154.066 bits (388), Expect = 1.308e-40 Identity = 94/248 (37.90%), Postives = 131/248 (52.82%), Query Frame = 3
Query: 168 ITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATAL---KGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIV 893
+ EE GVL+L + NF+ + VL+EFYAPWCGHC+ A E++K A L + V VD L + + + G+PTIKI K + DY G+RT +I+ A +KE+ +S V+ LT+SNFDE+V + LVEF+APWCGHCK L P +++AA EL + L +DATV + R+GV GYPT+K F + G + DY+G R IV
Sbjct: 52 VKEENGVLILKDLNFDFFVAGKDTVLLEFYAPWCGHCKEFASEYEKIAKELAENDPPIPVAKVDATVAVHLAERFSVSGYPTIKILKKGQAV--DYDGDRTQDAII-AKVKEV---------------------ASPDWKPPPEAVLTLTESNFDEIV-NDADIILVEFYAPWCGHCKKLAPEYEKAAQELSKNTPPIPLAKVDATVESELGKRFGVSGYPTLKLF----RKGKAYDYNGPREQYGIV 270 HSP 2 Score: 97.0561 bits (240), Expect = 1.622e-21 Identity = 48/108 (44.44%), Postives = 67/108 (62.04%), Query Frame = 3
Query: 180 EGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKG---VVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKE 494
E VL LT SNF+E++ +LVEFYAPWCGHC+ LAPE++KAA L + + VD S LG+ +G+ G+PT+K+F K K DY G R IV+ +++
Sbjct: 171 EAVLTLTESNFDEIVNDADIILVEFYAPWCGHCKKLAPEYEKAAQELSKNTPPIPLAKVDATVESELGKRFGVSGYPTLKLFRKGKAY--DYNGPREQYGIVSHMIEQ 276 HSP 3 Score: 79.337 bits (194), Expect = 6.282e-16 Identity = 71/224 (31.70%), Postives = 97/224 (43.30%), Query Frame = 3
Query: 594 VVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQ-LPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLW-TEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGI 1250
V+ L D NFD V ++ L+EF+APWCGHCK +++ A EL + + +DATV A R+ V GYPTIK +K G + DYDG R+ I+ + P PE L + D + +V C C+ K A + K+ L +A EL FG+ GYP L + RK K GP Q GI
Sbjct: 58 VLILKDLNFDFFV-AGKDTVLLEFYAPWCGHCKEFASEYEKIAKELAENDPPIPVAKVDATVAVHLAERFSVSGYPTIKI----LKKGQAVDYDGDRTQDAIIAKVKEVASPDWKPPPEAVLTLTESNFDEIVNDADIILVEFYAPW--C-GHCKKLAPEYEKAAQELSKNTPPIPLAKVDATVESELGKRFGVS--GYPTLKL--FRKGKAYDYNGPREQYGI 269 HSP 4 Score: 75.485 bits (184), Expect = 1.057e-14 Identity = 34/97 (35.05%), Postives = 56/97 (57.73%), Query Frame = 3
Query: 615 NFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK--VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRW 899
F++MVL + + L+EF+APWCGHCK+L+P + + +G + + +DATV+ Y +G+PTI F P+G K + DG R + ++
Sbjct: 529 TFEQMVLDNSKDVLIEFYAPWCGHCKSLEPIYKDLGKKYKGHKGLVIAKMDATVNDIPHDSYKAEGFPTIYFSPSGAKDRPIKFADGSRDLESLSKF 625 HSP 5 Score: 55.8398 bits (133), Expect = 1.418e-8 Identity = 31/77 (40.26%), Postives = 42/77 (54.55%), Query Frame = 3
Query: 186 VLVLTNSNFNE-VIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSS--LGQPYGIQGFPTI 407
V V+ F + V++ +K VL+EFYAPWCGHC+SL P +K KG + MD + Y +GFPTI
Sbjct: 522 VKVVVGRTFEQMVLDNSKDVLIEFYAPWCGHCKSLEPIYKDLGKKYKGHKGLVIAKMDATVNDIPHDSYKAEGFPTI 598
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Sea Lamprey
Match: dnajc10 (DnaJ (Hsp40) homolog, subfamily C, member 10 [Source:ZFIN;Acc:ZDB-GENE-070327-1]) HSP 1 Score: 125.176 bits (313), Expect = 1.574e-30 Identity = 69/221 (31.22%), Postives = 107/221 (48.42%), Query Frame = 3
Query: 186 VLVLTNSNFNEVIEKNKYV---LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQG----ERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFF 827
V+ LT + ++++ K +V+FYAPWCG CQ+L PEWK+ A L G+V+VG+VD K+ +L Q + +P I++F + S Y R A S+ A L + +LT F+ VL+ E WLV+F+ PWCGHC+ P ++ AA L+GK++ G ++ G+ GYPT+ F+
Sbjct: 559 VVTLTPETYVSLVKQRKRDEVWMVDFYAPWCGPCQALLPEWKRMARMLSGMVQVGSVDCQKHHALCQSEMVHAYPEIRLFPMNPASSDKYFKYNGWHRDANSLKGWAFGYLPQTAE-----------------------------DLTPQKFNSEVLEGMEHWLVDFYTPWCGHCQIFAPEFEIAARLLKGKLRTGKVNCQNDPHVCQSAGIHGYPTVMFY 750 HSP 2 Score: 118.627 bits (296), Expect = 1.883e-28 Identity = 71/224 (31.70%), Postives = 111/224 (49.55%), Query Frame = 3
Query: 243 LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMV--LKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQ-DYDG-GRSSSDIVRWA 902
L++F+APWC C++L PE +KA+ L G +K G +D +S + +GI +PT IF +S + +Y G+ +A ++L E V+ + + VV LT + +V K +E W+V+F+APWCG C+ L P W + A L G V++G++D H A V YP I+ FP S D Y+G R ++ + WA
Sbjct: 473 LIDFFAPWCPPCRALLPELRKASRLLTGQLKFGTIDCTIHSKICNLHGIHAYPTTLIFNQS--NIHEYNGQHSA--------EQLMEYVQDLMSPS---------------------VVTLTPETYVSLVKQRKRDEVWMVDFYAPWCGPCQALLPEWKRMARMLSGMVQVGSVDCQKHHALCQSEMVHAYPEIRLFPMNPASSDKYFKYNGWHRDANSLKGWA 665 HSP 3 Score: 85.8853 bits (211), Expect = 6.998e-18 Identity = 54/206 (26.21%), Postives = 92/206 (44.66%), Query Frame = 3
Query: 294 EWKKAATALKGV-VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASD 908
E+KK T LK +KVG +D + + + I + GK H + + G+ T +V+ A + ++ LV + L+ F E K +EPWL++FFAPWC C+ L P +A+ L G++K G +D T+H+ + +G+ YPT F + +Y+G S+ ++ + D
Sbjct: 384 EFKKLNTLLKSKNIKVGTLDCNPFPYICDQLYINSRAVVVFKGKGLHEYEIHHGKTTLYELVSFAKESVNSLVHT-----------------------------LSPETFPE---KDKEPWLIDFFAPWCPPCRALLPELRKASRLLTGQLKFGTIDCTIHSKICNLHGIHAYPTTLIF----NQSNIHEYNGQHSAEQLMEYVQD 553 HSP 4 Score: 74.7146 bits (182), Expect = 2.299e-14 Identity = 38/84 (45.24%), Postives = 52/84 (61.90%), Query Frame = 3
Query: 195 LTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIF---GKSKHS 434
LT FN EV+E ++ LV+FY PWCGHCQ APE++ AA LKG ++ G V+ + Q GI G+PT+ + G+SK S
Sbjct: 676 LTPQKFNSEVLEGMEHWLVDFYTPWCGHCQIFAPEFEIAARLLKGKLRTGKVNCQNDPHVCQSAGIHGYPTVMFYQYQGRSKRS 759 HSP 5 Score: 69.3218 bits (168), Expect = 1.074e-12 Identity = 55/222 (24.77%), Postives = 93/222 (41.89%), Query Frame = 3
Query: 186 VLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNF---DEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQA-ASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGV 839
VL L F+ + + V FY+P C HC LAP W++ A + GV++V AV+ + + GI +P++ ++ ++ P Y G+R+ +V +K V S+ V EL NF E +E WL+ + + G C L H + A L G +G +D + S+ ++ T+ F+P G+
Sbjct: 133 VLTLDRGEFDAAVSSGELFFVNFYSPRCSHCHELAPMWREFAKEMDGVIRVAAVNCGDNRMMCRSKGIGSYPSLYVY-RAGMQPVKYSGDRSKDDLVRFVMK----YVTSK-------------------------VTELWAGNFVNAFEQAGSTETGWLLSYCSD-IGDC--LSQHTRRKLAGMLDGMANVGWVDCSTQKHICSQMNIEESKTV-FYPPGL 320 HSP 6 Score: 62.3882 bits (150), Expect = 1.451e-10 Identity = 33/112 (29.46%), Postives = 56/112 (50.00%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQL 926
+V+ L FD V S E + V F++P C HC L P W + A E+ G +++ A++ + G+ YP++ + AG++ Y G RS D+VR+ V ++
Sbjct: 132 EVLTLDRGEFDAAV-SSGELFFVNFYSPRCSHCHELAPMWREFAKEMDGVIRVAAVNCGDNRMMCRSKGIGSYPSLYVYRAGMQ---PVKYSGDRSKDDLVRFVMKYVTSKV 239
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006474.1 (pep scaffold:Pmarinus_7.0:GL478000:14574:47610:1 gene:ENSPMAG00000005827.1 transcript:ENSPMAT00000006474.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 123.25 bits (308), Expect = 1.986e-30 Identity = 80/252 (31.75%), Postives = 122/252 (48.41%), Query Frame = 3
Query: 177 EEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVK-----VGAVDMDKYSSLGQPYGIQGFPTIKIF--GKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR--GKVKLGALDATV--HTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRW 899
+ V LT+ +F + ++K+ VLV FYAPWCGHC+ L P++ +AA L + + AVD + +L + + I+GFPT+K F G+ K++ D + + S + DV L+ + F E LK + L+ F+APWC HCK KPH+ AA++LR KV L A+D T + S+ GV+GYPT+ + G G Y GGR +D + +
Sbjct: 277 DSAVFHLTDEDFQDFVDKHPNVLVMFYAPWCGHCKKLKPDYDEAAKILNNEEENSPGVLAAVDATIHRALAERFAIKGFPTMKFFQDGEEKYTVSDLRSKDKILSWIR--------------------DPQPPPPPEVPWDEQENDVAHLSVATFREF-LKKKRHALLMFYAPWCFHCKQAKPHFTAAAAQLREDHKVALAAVDCTKQDNNELCSQEGVRGYPTMNHYTYGKFVG---PYTGGRQEADFINF 504 HSP 2 Score: 114.39 bits (285), Expect = 1.893e-27 Identity = 79/249 (31.73%), Postives = 124/249 (49.80%), Query Frame = 3
Query: 186 VLVLTNSNFNEVIEKN-KYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMD--KYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVK-----LGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASD 908
V V ++ F +++K + +L+ FYAPWCG C+ + P +++AAT K + +++ ++ + Y + G+PT F K K +YQ A K++ E +++ S S + V LTD +F + V K LV F+APWCGHCK LKP +D+AA L + + L A+DAT+H A A R+ ++G+PT+KFF G + D RS I+ W D
Sbjct: 156 VHVHSDKEFRLLLKKEERPILMMFYAPWCGVCKRMKPVFQEAATMAKKTYVLAGMNVHPAEFDGIKSDYNVTGYPTFCYFEKGKFR-FNYQS-------YGAQAKDIVEWLKN-------PESPKPTVPEVAWSETDSAVFHLTDEDFQDFVDKHPNV-LVMFYAPWCGHCKKLKPDYDEAAKILNNEEENSPGVLAAVDATIHRALAERFAIKGFPTMKFFQDGEEKYTVSDL---RSKDKILSWIRD 385 HSP 3 Score: 72.4034 bits (176), Expect = 7.749e-14 Identity = 69/244 (28.28%), Postives = 109/244 (44.67%), Query Frame = 3
Query: 591 DVVEL-TDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTA----TASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEI----LNQEILKSACEDHQLCVVAVLPNIL---------DCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRD 1268
DVV + +D F ++ K E P L+ F+APWCG CK +KP + +AA+ + L ++ VH A S Y V GYPT +F G + Q Y G + DIV W + + P P + E+ + + ED Q V PN+L C+ + + DY K+ ++ +++ +A L F I GF P + + KY T++ S+ I ++RD
Sbjct: 154 DVVHVHSDKEFRLLLKKEERPILMMFYAPWCGVCKRMKPVFQEAATMAKKTYVLAGMN--VHPAEFDGIKSDYNVTGYPTFCYFEKGKFRFNYQSY--GAQAKDIVEWLKNP---ESPKPTVPEVAWSETDSAVFHLTDEDFQD-FVDKHPNVLVMFYAPWCGHCK-KLKPDYDEAAKILNNEEENSPGVLAAVDATIHRALAERFAIKGF--PTMKFFQDGEEKY-TVSDLRSKDKILSWIRD 385 HSP 4 Score: 59.6918 bits (143), Expect = 8.994e-10 Identity = 36/109 (33.03%), Postives = 54/109 (49.54%), Query Frame = 3
Query: 174 EEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKV--GAVDMDKY--SSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAAL 488
+E V L+ + F E ++K ++ L+ FYAPWC HC+ P + AA L+ KV AVD K + L G++G+PT+ + K Y G R +N L
Sbjct: 399 QENDVAHLSVATFREFLKKKRHALLMFYAPWCFHCKQAKPHFTAAAAQLREDHKVALAAVDCTKQDNNELCSQEGVRGYPTMNHYTYGKFV-GPYTGGRQEADFINFLL 506
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Sea Lamprey
Match: txndc5 (thioredoxin domain containing 5 [Source:ZFIN;Acc:ZDB-GENE-040426-1951]) HSP 1 Score: 113.62 bits (283), Expect = 1.282e-27 Identity = 78/265 (29.43%), Postives = 130/265 (49.06%), Query Frame = 3
Query: 165 DITE-EEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALK--GVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSI-----VNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHW-DQAASELRG--KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQL 926
DI E + G+ LT+ +F E + + Y ++F+APWCGHC++L P W++ A+ + G VK+ VD + + ++G+PT+ F K Y+G+R S+ ++ DE+V + G V+ L ++NFD V ++ V+F+APWCGHCKNL P W D A E G KV + +D T S+ V+GYPT+ + G + G +++G R+ + + + ++L
Sbjct: 164 DIPEPQHGLYELTSGSFKEHVAEG-YHFIKFFAPWCGHCKALIPAWEQLASTFEYSGKVKIAKVDCTAHQDICNENQVRGYPTLLWF-KDGEKVDQYRGKRDLDSLKVFVDTQIQIEPEDEVVTQQ----------------AGDEEEASSVLVLNENNFDATV--ADGITFVKFYAPWCGHCKNLAPTWEDLAKKEFSGLSKVTIAKVDCTSEAQLCSKQHVRGYPTLLLYVGGKQVG---EHEGTRNLEALHSYVLSRARDEL 405 HSP 2 Score: 111.309 bits (277), Expect = 6.519e-27 Identity = 75/239 (31.38%), Postives = 114/239 (47.70%), Query Frame = 3
Query: 243 LVEFYAPWCGHCQSLAPEWKKAATALKGVVK----VGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAAS--ELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEI 941
+ F+APWCGHCQ L W + + V VD ++ +G++G+PT+K+F + S YQG+R ++ + L+ L+E G + S + ELT +F E V +E ++FFAPWCGHCK L P W+Q AS E GKVK+ +D T H + V+GYPT+ +F K G+ D G+ D ++ D ++ P E+
Sbjct: 61 FIMFFAPWCGHCQKLQSTWNTLGDKYNEMPEPPAYVAKVDCTMHAQTCSDHGVKGYPTLKLFKPGQKSIL-YQGQRDLDTLESWMLQTLNE---------DAGVHEESERPSPDIPEPQHGLYELTSGSFKEHV--AEGYHFIKFFAPWCGHCKALIPAWEQLASTFEYSGKVKIAKVDCTAHQDICNENQVRGYPTLLWF----KDGEKVDQYRGKRDLDSLKVFVDTQIQIEPEDEV 283 HSP 3 Score: 67.3958 bits (163), Expect = 2.404e-12 Identity = 41/122 (33.61%), Postives = 59/122 (48.36%), Query Frame = 3
Query: 624 EMVLKS--EEPWLVEFFAPWCGHCKNLKPHW----DQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVE--------QLPAPEIKE 947
EM++ S + P + FFAPWCGHC+ L+ W D+ + +D T+H T S +GV+GYPT+K F G K S Y G R + W + E + P+P+I E
Sbjct: 49 EMLVHSVDQAPHFIMFFAPWCGHCQKLQSTWNTLGDKYNEMPEPPAYVAKVDCTMHAQTCSDHGVKGYPTLKLFKPGQK---SILYQGQRDLDTLESWMLQTLNEDAGVHEESERPSPDIPE 167 HSP 4 Score: 62.7734 bits (151), Expect = 7.745e-11 Identity = 40/124 (32.26%), Postives = 64/124 (51.61%), Query Frame = 3
Query: 147 LAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKK-AATALKGVVKV--GAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAAL-KELDEL 506
+ Q D E VLVL +NF+ + + V+FYAPWCGHC++LAP W+ A G+ KV VD + L ++G+PT+ ++ K +++G R ++ + L + DEL
Sbjct: 284 VTQQAGDEEEASSVLVLNENNFDATV-ADGITFVKFYAPWCGHCKNLAPTWEDLAKKEFSGLSKVTIAKVDCTSEAQLCSKQHVRGYPTLLLYVGGKQV-GEHEGTRNLEALHSYVLSRARDEL 405
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Yeast
Match: PDI1 (Protein disulfide isomerase; multifunctional oxidoreductase of the ER lumen, essential for disulfide bond formation in secretory and cell-surface proteins, processing of non-native disulfide bonds; Ero1p activator; complexes with exomannosidase, Mnl1p to facilitate the recognition of misfolded glycoproteins and the trimming of glycan Man8GlcNAc2 to Man7GlcNAc2 on substrates, thereby accelerating ERAD; PDI1 has a paralog, EUG1, that arose from the whole genome duplication [Source:SGD;Acc:S000000548]) HSP 1 Score: 92.0485 bits (227), Expect = 2.587e-20 Identity = 47/118 (39.83%), Postives = 72/118 (61.02%), Query Frame = 3
Query: 147 LAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAA-TALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSK-HSPKDYQGERTAGSIVNAALKE 494
AQ A E+ V+ L +FNE I+ + VL EF+APWCGHC+++APE+ KAA T ++ + + +D + L + I GFP++KIF S ++ DY+G RTA +IV +K+
Sbjct: 21 FAQQEAVAPEDSAVVKLATDSFNEYIQSHDLVLAEFFAPWCGHCKNMAPEYVKAAETLVEKNITLAQIDCTENQDLCMEHNIPGFPSLKIFKNSDVNNSIDYEGPRTAEAIVQFMIKQ 138 HSP 2 Score: 75.0998 bits (183), Expect = 7.815e-15 Identity = 43/120 (35.83%), Postives = 67/120 (55.83%), Query Frame = 3
Query: 594 VVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK-VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDK------VVEQLPA 932
VV+L +F+E + +S + L EFFAPWCGHCKN+ P + +AA L K + L +D T + + + G+P++K F +S DY+G R++ IV++ + VV LPA
Sbjct: 34 VVKLATDSFNEYI-QSHDLVLAEFFAPWCGHCKNMAPEYVKAAETLVEKNITLAQIDCTENQDLCMEHNIPGFPSLKIF-KNSDVNNSIDYEGPRTAEAIVQFMIKQSQPAVAVVADLPA 151 HSP 3 Score: 63.929 bits (154), Expect = 2.945e-11 Identity = 39/99 (39.39%), Postives = 53/99 (53.54%), Query Frame = 3
Query: 594 VVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAA---SELRGKVKLGALDATVHTATASR-YGVQGYPTIKFFPAGVKSGDSQDYDGGRS 878
V +L N DE+V ++ LV ++APWCGHCK L P + + A + V + LD HT R ++GYPTI +P G KS +S Y G RS
Sbjct: 378 VFQLVGKNHDEIVNDPKKDVLVLYYAPWCGHCKRLAPTYQELADTYANATSDVLIAKLD---HTENDVRGVVIEGYPTIVLYPGGKKS-ESVVYQGSRS 472 HSP 4 Score: 60.077 bits (144), Expect = 4.778e-10 Identity = 35/106 (33.02%), Postives = 56/106 (52.83%), Query Frame = 3
Query: 171 TEEEGVLVLTNSNFNEVI-EKNKYVLVEFYAPWCGHCQSLAPEWKKAA-TALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIF-GKSKHSPKDYQGERTAGSIVN 479
++ V L N +E++ + K VLV +YAPWCGHC+ LAP +++ A T V +D + + I+G+PTI ++ G K YQG R+ S+ +
Sbjct: 373 NQDSSVFQLVGKNHDEIVNDPKKDVLVLYYAPWCGHCKRLAPTYQELADTYANATSDVLIAKLDHTENDVRGVVIEGYPTIVLYPGGKKSESVVYQGSRSLDSLFD 478
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Yeast
Match: MPD1 (Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation [Source:SGD;Acc:S000005814]) HSP 1 Score: 84.7297 bits (208), Expect = 1.628e-18 Identity = 52/158 (32.91%), Postives = 78/158 (49.37%), Query Frame = 3
Query: 111 MKYLSIV-----LFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYV-LVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAV--DMDKYSSLGQPYGIQGFPTIKIFGKSK----------------HSPKDYQGERTAGSIVNAALKELDELVR 512
M +L+I+ LF + + + LT +F++ I Y LVEFYAPWCGHC+ L+ ++KAA L GVV+V AV D++K +L Y + GFPT+ +F K H+ + Y G RT IV+ +L + V+
Sbjct: 1 MLFLNIIKLLLGLFIMNEVKAQNFYDSDPHISELTPKSFDKAIHNTNYTSLVEFYAPWCGHCKKLSSTFRKAAKRLDGVVQVAAVNCDLNKNKALCAKYDVNGFPTLMVFRPPKIDLSKPIDNAKKSFSAHANEVYSGARTLAPIVDFSLSRIRSYVK 158 HSP 2 Score: 68.9366 bits (167), Expect = 2.899e-13 Identity = 32/80 (40.00%), Postives = 48/80 (60.00%), Query Frame = 3
Query: 594 VVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGAL--DATVHTATASRYGVQGYPTIKFF 827
+ ELT +FD+ + + LVEF+APWCGHCK L + +AA L G V++ A+ D + A ++Y V G+PT+ F
Sbjct: 31 ISELTPKSFDKAIHNTNYTSLVEFYAPWCGHCKKLSSTFRKAAKRLDGVVQVAAVNCDLNKNKALCAKYDVNGFPTLMVF 110
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Yeast
Match: EUG1 (Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER [Source:SGD;Acc:S000002926]) HSP 1 Score: 71.633 bits (174), Expect = 9.755e-14 Identity = 43/107 (40.19%), Postives = 58/107 (54.21%), Query Frame = 3
Query: 123 SIVLFC----FALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALK-GVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSK 428
+IV FC F LA+ +A T +LVLT F IE + VLVEF+APWC H Q L P ++AA+ LK V V +D + S + I +PT+KIF +
Sbjct: 10 AIVSFCLFASFTLAENSARATPGSDLLVLTEKKFKSFIESHPLVLVEFFAPWCLHSQILRPHLEEAASILKEHNVPVVQIDCEANSMVCLQQTINTYPTLKIFKNGR 116 HSP 2 Score: 64.6994 bits (156), Expect = 1.682e-11 Identity = 35/104 (33.65%), Postives = 58/104 (55.77%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR-GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRW 899
D++ LT+ F + +S LVEFFAPWC H + L+PH ++AAS L+ V + +D ++ + + YPT+K F G + D Q Y G + + +I ++
Sbjct: 34 DLLVLTEKKFKSFI-ESHPLVLVEFFAPWCLHSQILRPHLEEAASILKEHNVPVVQIDCEANSMVCLQQTINTYPTLKIFKNG-RIFDGQVYRGVKITDEITQY 135
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Yeast
Match: TRX1 (Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication [Source:SGD;Acc:S000004033]) HSP 1 Score: 48.521 bits (114), Expect = 8.755e-8 Identity = 25/81 (30.86%), Postives = 41/81 (50.62%), Query Frame = 3
Query: 198 TNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPK 440
T S F+ I ++K V+V+FYA WCG C+ +AP +K + +D+D+ + Q + PT+ +F K K
Sbjct: 7 TASEFDSAIAQDKLVVVDFYATWCGPCKMIAPMIEKFSEQYPQ-ADFYKLDVDELGDVAQKNEVSAMPTLLLFKNGKEVAK 86
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Yeast
Match: EPS1 (ER protein with chaperone and co-chaperone activity; involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family [Source:SGD;Acc:S000001267]) HSP 1 Score: 46.9802 bits (110), Expect = 6.546e-6 Identity = 29/105 (27.62%), Postives = 51/105 (48.57%), Query Frame = 3
Query: 195 LTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKV-----GAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKE 494
L +NF E + K ++ ++FY+P+C HC+ LAP W + K K V+ + + L I+ FP I+++ S + + RT S++ A +E
Sbjct: 37 LNPTNFKEELSKGLHI-IDFYSPYCPHCKHLAPVWMETWEEFKEESKTLNITFSQVNCIESADLCGDENIEYFPEIRLYNPSGYIKSFTETPRTKESLIAFARRE 140
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Nematostella
Match: EDO37155 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SGL1]) HSP 1 Score: 491.5 bits (1264), Expect = 1.108e-171 Identity = 238/417 (57.07%), Postives = 311/417 (74.58%), Query Frame = 3
Query: 186 VLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDS-QDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGI---EEPKSE 1421
V+ LT +NFN VI + +VEFYAPWCGHC++LAPEW KAATALKGVVKVGAVDMD + S+G PY I+GFPTIKIFG +K+SP+DY G+RTA IV+AA++ E V R+ G SS + G DVVELTD+NF++ VL S++ WLVEFFAPWCGHC+ L P W +AA+EL+GKVK+GALDATVHT TASRY VQGYPTIK F AG+K+ S +DY GGR++SDI+++A DK + + PE+ + ++ E+LK C +H +CV+A LP+ILD + RN Y+A LK G+KYK NRWGWLW+EA P+LE +GGFGYPA+V VN+RK K+A L G F ++GI +F+R VS+GRGST+ + GD LP + S+E WDGKDG++P+EE+IDLS++ + +EPK E
Sbjct: 14 VVELTANNFNNRVINDDAVWMVEFYAPWCGHCKALAPEWMKAATALKGVVKVGAVDMDVHQSVGGPYNIRGFPTIKIFGANKNSPQDYNGQRTAQGIVDAAMRAAQEAVSQRMSGGGRSSSGGGGRRGGSGGNKE-DVVELTDTNFEKEVLNSKDLWLVEFFAPWCGHCQRLAPEWAKAATELKGKVKVGALDATVHTVTASRYQVQGYPTIKVFAAGIKNSHSVEDYQGGRTASDIIQYALDKAADSIEPPEVIQAISNEVLKEGCNEHPICVIAFLPHILDSGASGRNTYLANLKELGEKYKKNRWGWLWSEAAAQPKLEEAVEVGGFGYPAMVAVNIRKKKFAVLKGSFDRTGIDEFLRTVSVGRGSTATMRGDSLPELSSIEAWDGKDGQLPQEEDIDLSDVDLDDEDEPKKE 429 HSP 2 Score: 113.235 bits (282), Expect = 3.461e-27 Identity = 53/116 (45.69%), Postives = 75/116 (64.66%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIV----RWASDKVVEQL 926
DVVELT +NF+ V+ + W+VEF+APWCGHCK L P W +AA+ L+G VK+GA+D VH + Y ++G+PTIK F G QDY+G R++ IV R A + V +++
Sbjct: 13 DVVELTANNFNNRVINDDAVWMVEFYAPWCGHCKALAPEWMKAATALKGVVKVGAVDMDVHQSVGGPYNIRGFPTIKIF--GANKNSPQDYNGQRTAQGIVDAAMRAAQEAVSQRM 126
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Nematostella
Match: EDO47340 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMG9]) HSP 1 Score: 167.933 bits (424), Expect = 3.417e-47 Identity = 97/267 (36.33%), Postives = 141/267 (52.81%), Query Frame = 3
Query: 129 VLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATAL--KGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDEL--VRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVK--LGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDK 911
VLF L + +T+ + V+ LT NF+EV+ K+ LVEFYAPWCGHC+ LAP +++ A V + VD D LG + ++GFPTIK F K +P++Y G R +N +K ++E VR R+ V +L +SNFD++V + LVEFFAPWCGHCKNL P +++ + + + +DA H+A +YGV GYPT+KFF K G ++Y GR V + ++K
Sbjct: 6 VLFKLFLLFSISSLTQGK-VIDLTKDNFDEVVNGEKFALVEFYAPWCGHCKQLAPTYEQLGEAYTQSSDVIIAKVDADGDRDLGSRFDVKGFPTIKYFPKGSTTPEEYNGGRD----INDFIKFIEEKTGVRGRVPVIPSA------------------VADLDESNFDKIVKNPDNNVLVEFFAPWCGHCKNLAPVYEKVGEAFKNEPNCVIAKVDADAHSALGQKYGVSGYPTLKFFSKTNKDG--EEYSSGRDEQSFVDFMNEK 247
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Nematostella
Match: EDO32930 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7STM8]) HSP 1 Score: 170.244 bits (430), Expect = 5.130e-46 Identity = 98/256 (38.28%), Postives = 136/256 (53.12%), Query Frame = 3
Query: 165 DITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALK---GVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKV 914
++ EE+ VLVL + NF+ VIE+N +LVEFYAPWCGHC+SLAPE+ KAA +K V +D S + Q + + G+PT+KIF K +P +Y+G R IV K+ D + + LT NF E V+ E LVEFFAPWCGHCK L P +++AA EL+ + L +DAT+ + A +Y VQGYPT+K F + G + +Y G R I + +V
Sbjct: 56 EVKEEDDVLVLNSKNFDRVIEENNIILVEFYAPWCGHCKSLAPEYAKAAKKMKLNDPPVPFAKMDATVASDIAQRFDVSGYPTLKIFRKG--TPYEYEGPREESGIVEYMKKQSDPNWKPPPVA----------------------ALTLTKENFTE-VVNRESLMLVEFFAPWCGHCKQLAPEYEKAAQELQKNDPPIPLAIVDATIESELAQKYEVQGYPTLKVF----RKGKATEYKGQRDQYGIASYMRSQV 282 HSP 2 Score: 75.0998 bits (183), Expect = 2.845e-14 Identity = 38/114 (33.33%), Postives = 62/114 (54.39%), Query Frame = 3
Query: 618 FDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRG--KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEIL 953
FDE+V ++ L+EF+APWCGHCK L+P + + R + + +DAT + S Y V+G+PTI +F + +DGGR D++++ +K L + K+ L
Sbjct: 535 FDEIVNDPKKDVLIEFYAPWCGHCKALEPTFKKLGKHFRNDKNIVIAKIDATAND-VPSTYAVEGFPTI-YFATSKDKKNPIKFDGGRELKDLIKFVEEKATVSLSKEKAKDEL 646 HSP 3 Score: 66.6254 bits (161), Expect = 1.371e-11 Identity = 37/109 (33.94%), Postives = 58/109 (53.21%), Query Frame = 3
Query: 171 TEEEGVLVLTNSNFNEVI-EKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKG-----VVKVGAVDMDKYSSLGQPYGIQGFPTIKI-FGKSKHSPKDYQGERTAGSIV 476
+ +E V V+ F+E++ + K VL+EFYAPWCGHC++L P +KK + + K+ A D S+ Y ++GFPTI K K +P + G R ++
Sbjct: 522 SNKEPVTVVVGKTFDEIVNDPKKDVLIEFYAPWCGHCKALEPTFKKLGKHFRNDKNIVIAKIDATANDVPST----YAVEGFPTIYFATSKDKKNPIKFDGGRELKDLI 626
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Nematostella
Match: EDO34590 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNX3]) HSP 1 Score: 123.25 bits (308), Expect = 5.298e-31 Identity = 77/250 (30.80%), Postives = 122/250 (48.80%), Query Frame = 3
Query: 171 TEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALK--GVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDE--LVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKV---KLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRW 899
T E GV +LT + F++ IE + V+FYAPWC HC LAP W++ A K + + +D + S +G+ GFPT+K+F + + Y G R+ + N ++ E L+ + S + + + +L + NFD V S V+F+APWC HCK L P WDQ A++ +V K+ +D T + +G+ GYPT+ F GV+ ++Y G R + R+
Sbjct: 107 TSEAGVHILTKNTFDKHIELGLH-FVKFYAPWCIHCIKLAPIWERLAEDFKDNADITISKIDCTAHGSKCSQHGVNGFPTLKLFKNGREVDR-YSGMRSLEDLKNYVKLKIAEHGLLSTVTTDKSETAEEVPPTDTDMDAADLIKPYQLNNQNFDTTV--SLGTTFVKFYAPWCRHCKILAPVWDQLANKCADQVAGPKIAKVDCTKEESLCQSFGINGYPTLMLFKDGVQ---KKEYSGNRDLDSLYRF 349 HSP 2 Score: 89.3521 bits (220), Expect = 2.163e-19 Identity = 66/232 (28.45%), Postives = 106/232 (45.69%), Query Frame = 3
Query: 243 LVEFYAPWCGHCQSLAPEWK---KAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELR--GKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQ 923
V FY PWC HC+++ P W+ + + K + + VD +L I+ +PT+K++ K Y G R A + +D++V + K S G S S V LT + FD+ + V+F+APWC HC L P W++ A + + + + +D T H + S++GV G+PT+K F G + Y G RS D+ + K+ E
Sbjct: 7 FVMFYGPWCEHCKNMMPAWEALGEQYSKEKRDLTIAKVDCTSDVNLCVKQNIRAYPTMKLYYDG--DIKRYTGRRNAEDMKVF----VDKIV---------LKPEGKSKDSEGLSTSEAGVHILTKNTFDKHIELGLH--FVKFYAPWCIHCIKLAPIWERLAEDFKDNADITISKIDCTAHGSKCSQHGVNGFPTLKLFKNG---REVDRYSGMRSLEDLKNYVKLKIAEH 218 HSP 3 Score: 71.2478 bits (173), Expect = 1.912e-13 Identity = 39/106 (36.79%), Postives = 54/106 (50.94%), Query Frame = 3
Query: 195 LTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVV---KVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDE 503
L N NF+ + V+FYAPWC HC+ LAP W + A V K+ VD K SL Q +GI G+PT+ +F K K+Y G R S+ ++ D+
Sbjct: 253 LNNQNFDTTVSLGT-TFVKFYAPWCRHCKILAPVWDQLANKCADQVAGPKIAKVDCTKEESLCQSFGINGYPTLMLF-KDGVQKKEYSGNRDLDSLYRFIMQNHDK 356 HSP 4 Score: 57.7658 bits (138), Expect = 4.418e-9 Identity = 29/96 (30.21%), Postives = 49/96 (51.04%), Query Frame = 3
Query: 639 SEEPWLVEFFAPWCGHCKNLKPHWD---QAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVV 917
S P V F+ PWC HCKN+ P W+ + S+ + + + +D T + ++ YPT+K + GD + Y G R++ D+ + DK+V
Sbjct: 2 SSTPHFVMFYGPWCEHCKNMMPAWEALGEQYSKEKRDLTIAKVDCTSDVNLCVKQNIRAYPTMKLY----YDGDIKRYTGRRNAEDMKVFV-DKIV 92
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Nematostella
Match: EDO41376 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4E6]) HSP 1 Score: 121.709 bits (304), Expect = 7.163e-30 Identity = 81/248 (32.66%), Postives = 120/248 (48.39%), Query Frame = 3
Query: 186 VLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALK-----GVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKL--GALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASD 908
V+ L + F++ + KN VLV FYAPWCGHC+++ PE+ AA LK GV+ AVD K ++LG+ + ++G+PT + + + ER SIVN S +V L+D+ F V K ++ LV F+APWCGHCK KP AA + K K+ A+D T A ++GV+GYPT ++F G + Y GR + D +++ D
Sbjct: 243 VVHLRDDMFDDFVAKNPSVLVMFYAPWCGHCKAMKPEYVDAAQTLKEQEIPGVL--AAVDATKEAALGKRFKVEGYPTGTSYMDGEFAFD--VNERKGDSIVN--------------FMKDPKEPPRPPPPEQEWSEIPSEVYHLSDTTFKSFV-KKKKHVLVMFYAPWCGHCKKAKPELMSAAKHHKDKNKIAYAAVDCTKEMAVCQQFGVEGYPTFRYFNYG---KNDFKYTSGREAKDFIQFMDD 468 HSP 2 Score: 100.908 bits (250), Expect = 9.029e-23 Identity = 103/380 (27.11%), Postives = 160/380 (42.11%), Query Frame = 3
Query: 219 VIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYS--SLGQPYGIQGFPTIKIF--GKSKHSPKDYQGERTAGSIVN--------AALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKV---KLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVV-----------EQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLG 1280
+ + K VL+ FYAPWCG+C+ PE+ AAT K + +D+D S+ Y I GFPT F G+ K+ Y G+ ++V A +KE DE S + +VV L D FD+ V K+ LV F+APWCGHCK +KP + AA L+ + L A+DAT A R+ V+GYPT + G + D + R IV + D ++P+ E+ + + + + V+ P C+ + + + ++ K DK N+ + + K + FG+ GYP N K + +G ++ IQ F+ D G
Sbjct: 131 LTREKKPVLIMFYAPWCGYCKRFKPEFAAAATEHKDEAVLAGMDVDTEDGYSVRVHYNITGFPTTIYFELGQPKYK---YSGKHEKDALVQWMKDPSAVAPVKE-DEKPWS---------------------DTPSEVVHLRDDMFDDFVAKNPS-VLVMFYAPWCGHCKAMKPEYVDAAQTLKEQEIPGVLAAVDATKEAALGKRFKVEGYPTGTSYMDGEFAFDVNE----RKGDSIVNFMKDPKEPPRPPPPEQEWSEIPS-EVYHLSDTTFKSFVKKKKHVLVMFYAPWCGHCK-KAKPELMSAAKHHKDK---NKIAYAAVDCTKEMAVCQQFGVE--GYPTFRYFNYGKNDFKYTSGREAKDFIQ-FMDDPREG 472 HSP 3 Score: 64.6994 bits (156), Expect = 3.488e-11 Identity = 33/109 (30.28%), Postives = 54/109 (49.54%), Query Frame = 3
Query: 591 DVVELTDS-NFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASR--YGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASD 908
DVV L + +++ + ++P L+ F+APWCG+CK KP + AA+E + + L +D + R Y + G+PT +F G Y G +V+W D
Sbjct: 117 DVVHLEKAGELSKLLTREKKPVLIMFYAPWCGYCKRFKPEFAAAATEHKDEAVLAGMDVDTEDGYSVRVHYNITGFPTTIYFELG---QPKYKYSGKHEKDALVQWMKD 222
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Medaka
Match: pdia6 (protein disulfide isomerase family A member 6 [Source:NCBI gene;Acc:101171545]) HSP 1 Score: 464.151 bits (1193), Expect = 1.964e-160 Identity = 236/432 (54.63%), Postives = 310/432 (71.76%), Query Frame = 3
Query: 129 VLFCFALAQCNADITEEEGVLVLTNSNFN-EVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAAS----ELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
VL C L A + + V+ LT SNFN EV++ + LVEFYAPWCGHC++LAP+WKKAATALKG+VKVGAVD D++ SLG YG++GFPTIKIFG +K+ P++YQG R++ +IV+ A+ L LV+ RL G SG S + SG S S DVVELTD NFD+ VL+S++ WLVEFFAPWCGHCKNL+P W AA+ + +GKV+LGA+DATVH +SRYGV+G+PTIK F G + +DY GGR+ DI+ A D + P PE+ EILN+++LKS CE QLCV+AVLP+ILD + RN Y+ + KYK WGWLWTEA ELE+ GIGGFGYPA+ +N RKMK+A L G FS++GI +F+R++S+GRGST+ + G +P I +VEPWDGKDG++P EE+ DLS++ ++E
Sbjct: 8 VLGCSLLLSVEALYSPSDDVVELTPSNFNREVMQSDSLWLVEFYAPWCGHCRNLAPDWKKAATALKGIVKVGAVDADEHKSLGGQYGVRGFPTIKIFGANKNKPEEYQGARSSQAIVDGAMNALRSLVKDRLSGKSGSSGYSRQSDSGSSGSSK-DVVELTDDNFDKTVLQSDDVWLVEFFAPWCGHCKNLEPEWAAAATAVKEQTKGKVRLGAVDATVHQVLSSRYGVRGFPTIKIFRKGE---EPEDYQGGRTRGDIIERALDLFSDNAPPPELVEILNEDVLKSTCEGSQLCVIAVLPHILDTGAAGRNGYLEVMIKMAQKYKKKMWGWLWTEAGAQMELESALGIGGFGYPAMAAINTRKMKFALLKGSFSETGIHEFLRELSVGRGSTATLGGGVMPKIHAVEPWDGKDGQLPVEEDYDLSDVDLDE 435
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Medaka
Match: pdia6 (protein disulfide isomerase family A member 6 [Source:NCBI gene;Acc:101171545]) HSP 1 Score: 401.364 bits (1030), Expect = 4.742e-136 Identity = 211/431 (48.96%), Postives = 281/431 (65.20%), Query Frame = 3
Query: 129 VLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAAS----ELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEE 1409
VL C L A + + V+ LT SNFN + ++ L HC S G+VKVGAVD D++ SLG YG++GFPTIKIFG +K+ P++YQG R++ +IV+ A+ L LV+ RL G SG S K DVVELTD NFD+ VL+S++ WLVEFFAPWCGHCKNL+P W AA+ + +GKV+LGA+DATVH +SRYGV+G+PTIK F G + +DY GGR+ DI+ A D + P PE+ EILN+++LKS CE QLCV+AVLP+ILD + RN Y+ + KYK WGWLWTEA ELE+ GIGGFGYPA+ +N RKMK+A L G FS++GI +F+R++S+GRGST+ + G +P I +VEPWDGKDG++P EE+ DLS++ ++E
Sbjct: 10 VLGCSLLLSVEALYSPSDDVVELTPSNFNREVMQSDISL---------HCTS-------KGFCGTGIVKVGAVDADEHKSLGGQYGVRGFPTIKIFGANKNKPEEYQGARSSQAIVDGAMNALRSLVKDRLSGKSGSSGYSSSK----------DVVELTDDNFDKTVLQSDDVWLVEFFAPWCGHCKNLEPEWAAAATAVKEQTKGKVRLGAVDATVHQVLSSRYGVRGFPTIKIFRKGE---EPEDYQGGRTRGDIIERALDLFSDNAPPPELVEILNEDVLKSTCEGSQLCVIAVLPHILDTGAAGRNGYLEVMIKMAQKYKKKMWGWLWTEAGAQMELESALGIGGFGYPAMAAINTRKMKFALLKGSFSETGIHEFLRELSVGRGSTATLGGGVMPKIHAVEPWDGKDGQLPVEEDYDLSDVDLDE 411
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Medaka
Match: pdia4 (protein disulfide isomerase family A member 4 [Source:NCBI gene;Acc:101168751]) HSP 1 Score: 161.384 bits (407), Expect = 1.939e-42 Identity = 104/303 (34.32%), Postives = 153/303 (50.50%), Query Frame = 3
Query: 183 GVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKG---VVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILN-QEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLK 1070
GVLVLT++NF+ +E VLVEFYAPWCGHC+ APE++K A LK + V VD + S L + + G+PTIKI + P DY G RT +IV + + E+ + LT NFD+ V + + LVEF+APWCGHCK L P +++AA EL + + L +DATV T A RYGV G+PT+K F + G + +Y+G R + IV ++ P+ +++ + QE++K +V + N D + + TL+
Sbjct: 59 GVLVLTDNNFDTFMEGKDTVLVEFYAPWCGHCKQFAPEYEKIAQTLKDNDPPIPVAKVDATQASQLASKFDVSGYPTIKILKNGE--PVDYDGARTEKAIV----ERVKEVAHPDWKPPPDA------------------TLVLTQENFDDTV-NNADIILVEFYAPWCGHCKRLAPEYEKAAKELSKRTPPIPLAKVDATVETELAKRYGVNGFPTLKIF----RKGRAFEYNGPRENYGIVEHMGEQA--GPPSKQVQAVKQVQELIKDG---DDAVIVGIFSNEQDSAYELYTEACNTLR 327 HSP 2 Score: 89.3521 bits (220), Expect = 2.433e-18 Identity = 48/127 (37.80%), Postives = 69/127 (54.33%), Query Frame = 3
Query: 180 EGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV---VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVN-------------AALKELDELVR 512
+ LVLT NF++ + +LVEFYAPWCGHC+ LAPE++KAA L + + VD + L + YG+ GFPT+KIF K + +Y G R IV A+K++ EL++
Sbjct: 173 DATLVLTQENFDDTVNNADIILVEFYAPWCGHCKRLAPEYEKAAKELSKRTPPIPLAKVDATVETELAKRYGVNGFPTLKIFRKGRAF--EYNGPRENYGIVEHMGEQAGPPSKQVQAVKQVQELIK 297 HSP 3 Score: 65.855 bits (159), Expect = 5.207e-11 Identity = 31/90 (34.44%), Postives = 49/90 (54.44%), Query Frame = 3
Query: 615 NFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKL--GALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRS 878
FDE+V+ +++ L+EF+APWCGHCK L+P + + + + L +DAT + Y +G+PTI PA K + G R+
Sbjct: 530 TFDEIVMDTQKDVLIEFYAPWCGHCKKLEPDYLSLGKKYKKEKNLVIAKMDATANDIPNDNYKAEGFPTIYLAPANGKQSPVKFEGGDRT 619 HSP 4 Score: 60.4622 bits (145), Expect = 2.788e-9 Identity = 39/118 (33.05%), Postives = 60/118 (50.85%), Query Frame = 3
Query: 186 VLVLTNSNFNEVI-EKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSS--LGQPYGIQGFPTIKIF-GKSKHSPKDYQ-GERTAGSIVN------AALKELDEL 506
V V+ F+E++ + K VL+EFYAPWCGHC+ L P++ K + MD ++ Y +GFPTI + K SP ++ G+RT ++ N L++ DEL
Sbjct: 523 VKVVVGKTFDEIVMDTQKDVLIEFYAPWCGHCKKLEPDYLSLGKKYKKEKNLVIAKMDATANDIPNDNYKAEGFPTIYLAPANGKQSPVKFEGGDRTVEALSNFLEKHATKLQQKDEL 640
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Medaka
Match: txndc5 (thioredoxin domain containing 5 [Source:NCBI gene;Acc:101160445]) HSP 1 Score: 140.584 bits (353), Expect = 4.424e-37 Identity = 87/258 (33.72%), Postives = 138/258 (53.49%), Query Frame = 3
Query: 177 EEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV--VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGS---IVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQ-AASELRG--KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQL 926
++G+ LT NF E I K + V+F+APWCGHC+++AP W++ AT L+ VK+G VD ++ + G++G+PT+ +F + + Y+G+R S V+ LK L +++ + +V+ LT+S+FDE V K V+F+APWCGHCKNL P WD + E G VK+ +D TV ++Y V+GYPT+ F AG + GD ++ GGR + + + ++L
Sbjct: 81 KQGMYELTALNFKEHISKGAH-FVKFFAPWCGHCKAMAPTWEQLATTLEHSEDVKIGKVDCTQHYEVCSDNGVRGYPTL-LFFYNGQKKEQYKGKRDLDSFKDFVDNQLKALQTEEHEHELKEEQQAANEIPTEEPAKEEAESNVLVLTESDFDEAVAKGFT--FVKFYAPWCGHCKNLAPTWDDLSKKEFPGLTDVKIAKVDCTVERTLCNKYSVRGYPTLIIFRAG-EQGD--EHHGGRDLESLHNFVMKQTRDEL 331
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Medaka
Match: txndc5 (thioredoxin domain containing 5 [Source:NCBI gene;Acc:101160445]) HSP 1 Score: 140.198 bits (352), Expect = 2.737e-36 Identity = 87/258 (33.72%), Postives = 138/258 (53.49%), Query Frame = 3
Query: 177 EEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV--VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGS---IVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQ-AASELRG--KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQL 926
++G+ LT NF E I K + V+F+APWCGHC+++AP W++ AT L+ VK+G VD ++ + G++G+PT+ +F + + Y+G+R S V+ LK L +++ + +V+ LT+S+FDE V K V+F+APWCGHCKNL P WD + E G VK+ +D TV ++Y V+GYPT+ F AG + GD ++ GGR + + + ++L
Sbjct: 163 KQGMYELTALNFKEHISKGAH-FVKFFAPWCGHCKAMAPTWEQLATTLEHSEDVKIGKVDCTQHYEVCSDNGVRGYPTL-LFFYNGQKKEQYKGKRDLDSFKDFVDNQLKALQTEEHEHELKEEQQAANEIPTEEPAKEEAESNVLVLTESDFDEAVAKGFT--FVKFYAPWCGHCKNLAPTWDDLSKKEFPGLTDVKIAKVDCTVERTLCNKYSVRGYPTLIIFRAG-EQGD--EHHGGRDLESLHNFVMKQTRDEL 413 HSP 2 Score: 128.642 bits (322), Expect = 4.224e-32 Identity = 92/263 (34.98%), Postives = 120/263 (45.63%), Query Frame = 3
Query: 117 YLSIVLFCFALAQCNADITEEEGV-LVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKG-------VVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK--VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGR 875
Y S++ FA C+ D EEE T FNE + + V FYAPWCGHCQ L P W + A VVKV V K+ S +G++G+PT+ +F + + K YQG R S+ LK L + + ELT NF E + K V+FFAPWCGHCK + P W+Q A+ L VK+G +D T H S GV+GYPT+ FF G K + Y G R
Sbjct: 16 YFSLL---FAGVLCDTDAEEEEHAKHTYTVEMFNEAVPTAPH-FVMFYAPWCGHCQRLQPTWNELAEKYNSMDEPPVYVVKVDCVQDTKFCS--NVHGVRGYPTLLLFKPDQEAVK-YQGPRDLQSLETWMLKTLQAEPSEP----------ESELEPPKAPEPKQGMYELTALNFKEHISKGAH--FVKFFAPWCGHCKAMAPTWEQLATTLEHSEDVKIGKVDCTQHYEVCSDNGVRGYPTLLFFYNGQK---KEQYKGKR 256 HSP 3 Score: 53.5286 bits (127), Expect = 2.816e-7 Identity = 32/99 (32.32%), Postives = 48/99 (48.48%), Query Frame = 3
Query: 618 FDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK----VKLGALDATVHTATASR-YGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRW 899
F+E V + P V F+APWCGHC+ L+P W++ A + V + +D T S +GV+GYPT+ F ++ Y G R + W
Sbjct: 45 FNEAVPTA--PHFVMFYAPWCGHCQRLQPTWNELAEKYNSMDEPPVYVVKVDCVQDTKFCSNVHGVRGYPTLLLFKP---DQEAVKYQGPRDLQSLETW 138
BLAST of Protein disulfide-isomerase A6 vs. Planmine SMEST
Match: SMESG000017020.1 (SMESG000017020.1) HSP 1 Score: 768.074 bits (1982), Expect = 0.000e+0 Identity = 402/436 (92.20%), Postives = 414/436 (94.95%), Query Frame = 3
Query: 117 YLSIVLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEEPKSEL 1424
Y ++F +A + A + + V+ LT SNF+++ + VEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQG+RTAGSIVNAALKELDELVRSRLGGASGGSSSHERKSSGGSSGSGGDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEEPKSEL
Sbjct: 4 YSFFLIFLYAKSS-TALYSSNDDVVELTPSNFDDMKNSDSLWFVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGDRTAGSIVNAALKELDELVRSRLGGASGGSSSHERKSSGGSSGSGGDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAMKLPELENVFGIGGFGYPALVVVNVRKMKYATLTGPFSQSGIQDFVRDVSLGRGSTSGIHGDGLPTIKSVEPWDGKDGEIPKEEEIDLSELGIEEPKSEL 438
BLAST of Protein disulfide-isomerase A6 vs. Planmine SMEST
Match: SMESG000023147.1 (SMESG000023147.1) HSP 1 Score: 169.474 bits (428), Expect = 3.225e-46 Identity = 83/126 (65.87%), Postives = 96/126 (76.19%), Query Frame = 3
Query: 111 MKYLSIVLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALK---GVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVN 479
MKYLSIVLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHC++LAPE+ AA LK ++K+ VD + L + IQG+PT+K F K DY G RTA +I++
Sbjct: 1 MKYLSIVLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCKALAPEYASAAEKLKEKNSIIKLAKVDATVENDLASKFKIQGYPTLKFFKDGK--VMDYGGGRTADTIIS 124 HSP 2 Score: 104.76 bits (260), Expect = 1.019e-23 Identity = 58/145 (40.00%), Postives = 85/145 (58.62%), Query Frame = 3
Query: 594 VVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPN 1019
V+ LT+SNF+E++ K++ LVEF+APWCGHCK L P + AA +L+ K +KL +DATV AS++ +QGYPT+KFF K G DY GGR++ I+ W +E+ P + + E K+ E + VV +
Sbjct: 26 VLVLTNSNFNEVIEKNKY-VLVEFYAPWCGHCKALAPEYASAAEKLKEKNSIIKLAKVDATVENDLASKFKIQGYPTLKFF----KDGKVMDYGGGRTADTIISW-----LEKKTGPPAATLKSVEEAKALIESKDVVVVGFFKD 160 HSP 3 Score: 79.337 bits (194), Expect = 1.912e-15 Identity = 40/93 (43.01%), Postives = 52/93 (55.91%), Query Frame = 3
Query: 186 VLVLTNSNFNEVI-EKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERT 461
V VL NF+ V +K+K V VEFYAPWCGHC+ LAP W + K + MD ++ + IQ FPTIK F K D++G+RT
Sbjct: 367 VKVLVGKNFDSVARDKSKAVFVEFYAPWCGHCKQLAPIWDQLGETYKDNTDIVIAKMDSTANEVEGVRIQSFPTIKYFPKDSDEMVDFEGDRT 459 HSP 4 Score: 71.633 bits (174), Expect = 4.615e-13 Identity = 34/94 (36.17%), Postives = 50/94 (53.19%), Query Frame = 3
Query: 603 LTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK--VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRS 878
L NFD + + VEF+APWCGHCK L P WDQ + + + +D+T + R +Q +PTIK+FP S + D++G R+
Sbjct: 370 LVGKNFDSVARDKSKAVFVEFYAPWCGHCKQLAPIWDQLGETYKDNTDIVIAKMDSTANEVEGVR--IQSFPTIKYFPKD--SDEMVDFEGDRT 459
BLAST of Protein disulfide-isomerase A6 vs. Planmine SMEST
Match: SMESG000010656.1 (SMESG000010656.1) HSP 1 Score: 154.066 bits (388), Expect = 4.823e-40 Identity = 98/251 (39.04%), Postives = 124/251 (49.40%), Query Frame = 3
Query: 165 DITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKG---VVKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAA---SELRGKVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRW 899
+I + V VL + NF+E I N V+VEFYAPWCGHC+ L P + KAA LK + +G VD S L +GI G+PT+K F P DY R+ +IVN K S V+ LT NF ++V +S LVEFFAPWCGHCK+L P + +AA S L ++L +DATV T A Y V GYP++K F DY G RSS IV W
Sbjct: 23 EIPIDSNVYVLNSENFDEFINANNIVMVEFYAPWCGHCKQLTPIYTKAAVQLKKNNPPILLGKVDATVESELATRFGISGYPTLKFFKSG--IPYDYDDSRSESAIVNFMKK----------------------VGSPDWQPPKNYVLTLTKENFTQIV-ESSGYILVEFFAPWCGHCKSLAPEFAKAAKILSNLNPPIQLATVDATVETDLAKEYHVSGYPSLKLFK---NKNFFVDYSGPRSSDGIVDW 245 HSP 2 Score: 97.0561 bits (240), Expect = 5.009e-21 Identity = 45/105 (42.86%), Postives = 70/105 (66.67%), Query Frame = 3
Query: 186 VLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV---VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALK 491
VL LT NF +++E + Y+LVEF+APWCGHC+SLAPE+ KAA L + +++ VD + L + Y + G+P++K+F K+K+ DY G R++ IV+ +K
Sbjct: 145 VLTLTKENFTQIVESSGYILVEFFAPWCGHCKSLAPEFAKAAKILSNLNPPIQLATVDATVETDLAKEYHVSGYPSLKLF-KNKNFFVDYSGPRSSDGIVDWMIK 248
BLAST of Protein disulfide-isomerase A6 vs. Planmine SMEST
Match: SMESG000005268.1 (SMESG000005268.1) HSP 1 Score: 111.309 bits (277), Expect = 1.804e-25 Identity = 79/282 (28.01%), Postives = 129/282 (45.74%), Query Frame = 3
Query: 174 EEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMD----KYSSLGQPYGIQGFPTIKIFGKSKH-SPKDYQGERTAGSIV----NAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGKVK---LGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACE 983
E+ V+ F V+++ K+ LV FYAPWCGHC++ P++ AA + KV + +D ++ + GI GFP + F K+ S +Y ER V N A +LD R +V L +NF + ++ LV F++PWCGHC + P + AA++L+ + + A+DAT T A++Y V G+PT+ +F +GD Y G R+ I + K + + E +++ +E K+ E
Sbjct: 381 EQSQVIHPVPEEFRAVLKRYKHALVMFYAPWCGHCKATKPKFTSAANQMAENKKVAFIGVDCTDESFADICTSEGITGFPIFRYFNYGKNTSNSEYSLEREEDDFVAFMTNPANPQLDARRHWRRIPGHEA------------------IVILEKNNFVQNIVSHTSGALVMFYSPWCGHCIAMMPSFVNAANKLQTLLPSCLIAAVDATTETHLAAQYKVSGFPTLVYFSP---NGDWVKYMGERTDDAITEFMIKKHSDIIRHEEAEKLFQEEKKKADAE 641 HSP 2 Score: 109.383 bits (272), Expect = 6.175e-25 Identity = 75/260 (28.85%), Postives = 123/260 (47.31%), Query Frame = 3
Query: 174 EEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV---VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASEL--RGKVKLGALDATVHTAT--ASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPA 932
E + LT++NF E +++++ V+V FYAPWCGHC+++ P AA L+ + ++ A+D + ++ Q + I+GFPT+K F + A + + + D LV+ L E S V E + VLK + LV F+APWCGHCK KP + AA+++ KV +D T + + G+ G+P ++F G + +S+ Y R D V + ++ QL A
Sbjct: 259 ETNEIDFLTDANFYEYLDQHESVIVMFYAPWCGHCKAMKPAMVDAAVQLRKLKIDAQIAAIDSTENKNISQAFQIKGFPTVKYF-------------KNAQFMYDVNERSADGLVKFLLDPKKPEEPKLELPWKEEQSQVIHPVPEEFRA-----VLKRYKHALVMFYAPWCGHCKATKPKFTSAANQMAENKKVAFIGVDCTDESFADICTSEGITGFPIFRYFNYGKNTSNSE-YSLEREEDDFVAFMTNPANPQLDA 499 HSP 3 Score: 96.6709 bits (239), Expect = 7.186e-21 Identity = 64/239 (26.78%), Postives = 116/239 (48.54%), Query Frame = 3
Query: 240 VLVEFYAPWCGHCQSLAPEWKKAATALKG-VVKVGAV-DMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIVNAALKELDELVRSRLXXXXXXXXXXXXXXXXXXXXXXXDVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRG---KVKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEI 941
+++ FYAPWCG+C+ + P++ AAT LKG + +G D+ L Q + I G+P++ + K Y+G+ + +++ + + + + ++ LTD+NF E L E +V F+APWCGHCK +KP AA +LR ++ A+D+T + + + ++G+PT+K+F D + RS+ +V++ D + P E+
Sbjct: 160 MMLMFYAPWCGYCKQMKPQFAAAATTLKGKSIFIGINGDLSTTDDLKQAFNITGYPSVFLIQDGNKVFK-YEGDNSKEALIKFVHNPTQPPPQKDVPWSEETN----------------EIDFLTDANFYE-YLDQHESVIVMFYAPWCGHCKAMKPAMVDAAVQLRKLKIDAQIAAIDSTENKNISQAFQIKGFPTVKYFKNAQFMYDVNE----RSADGLVKFLLDPKKPEEPKLEL 376
BLAST of Protein disulfide-isomerase A6 vs. Planmine SMEST
Match: SMESG000041085.1 (SMESG000041085.1) HSP 1 Score: 90.8929 bits (224), Expect = 3.570e-19 Identity = 59/182 (32.42%), Postives = 88/182 (48.35%), Query Frame = 3
Query: 591 DVVELTDSNFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK---VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRWASDKVVEQLPAPEIKEILNQEILKSACEDHQLCVVAVLPNILDCQSQCRNDYIATLKVAGDKYKSNRWGWLWTEAM 1127
DV+E DS+F++ V K LVEF+APWCGHCK L P ++ AA+ L+ + + + +D T T T ++GV GYPT+K F G + DY G RS+ I+++ K P KE+ +E VV S+ + Y A L VA + R+ + E +
Sbjct: 18 DVLEFKDSSFEQSV-KEHSVILVEFYAPWCGHCKKLAPEYEIAATALKKQDPPIAIAKVDCTAETKTCEKHGVSGYPTLKVFKNG---QFAFDYSGERSADGIIKYMVSK-----SGPSSKELKTEENFNKFTASADPVVVGFF------TSESSDLYKAFLSVAEKLNEDFRFAHTFDETL 184 HSP 2 Score: 88.9669 bits (219), Expect = 1.515e-18 Identity = 47/125 (37.60%), Postives = 72/125 (57.60%), Query Frame = 3
Query: 111 MKYLSIVLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGV---VKVGAVDMDKYSSLGQPYGIQGFPTIKIFGKSKHSPKDYQGERTAGSIV 476
M L + F LA + VL +S+F + ++++ +LVEFYAPWCGHC+ LAPE++ AATALK + + VD + + +G+ G+PT+K+F K+ DY GER+A I+
Sbjct: 1 MNILISLFFLLPLAMAS-------DVLEFKDSSFEQSVKEHSVILVEFYAPWCGHCKKLAPEYEIAATALKKQDPPIAIAKVDCTAETKTCEKHGVSGYPTLKVF-KNGQFAFDYSGERSADGII 117 HSP 3 Score: 83.9593 bits (206), Expect = 5.367e-17 Identity = 48/124 (38.71%), Postives = 69/124 (55.65%), Query Frame = 3
Query: 177 EEGVLVLTNSNFNEVI-EKNKYVLVEFYAPWCGHCQSLAPEWKKAATALKGVVKVGAVDMDKYSS-LGQPYGIQGFPTIKIFGK-SKHSPKDYQGERTAGSIV-------NAALKELDELVRSR 518
+E V V+ NF+E++ + K VL+EFYAPWCGHC+SLAP++++ A L + MD ++ + PY + GFPTI K SKHSPK Y R ++ ++ LK D R R
Sbjct: 363 DEPVKVVVAKNFDEIVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSAESDIVIAKMDATANDVPSPYEVSGFPTIYFAPKNSKHSPKSYSSGREVDDMLKYIASEASSPLKNFDRQGRDR 486 HSP 4 Score: 75.8702 bits (185), Expect = 2.082e-14 Identity = 37/97 (38.14%), Postives = 57/97 (58.76%), Query Frame = 3
Query: 615 NFDEMVLKSEEPWLVEFFAPWCGHCKNLKPHWDQAASELRGK--VKLGALDATVHTATASRYGVQGYPTIKFFPAGVKSGDSQDYDGGRSSSDIVRW 899
NFDE+V + L+EF+APWCGHCK+L P +++ A +L + + + +DAT + S Y V G+PTI F P K + Y GR D++++
Sbjct: 373 NFDEIVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSAESDIVIAKMDATAND-VPSPYEVSGFPTIYFAPKNSKHS-PKSYSSGREVDDMLKY 467 The following BLAST results are available for this feature:
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Protein disulfide-isomerase A6 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30028938 ID=SMED30028938|Name=Protein disulfide-isomerase A6|organism=Schmidtea mediterranea sexual|type=transcript|length=1590bpback to top protein sequence of SMED30028938-orf-1 >SMED30028938-orf-1 ID=SMED30028938-orf-1|Name=SMED30028938-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=439bp MKYLSIVLFCFALAQCNADITEEEGVLVLTNSNFNEVIEKNKYVLVEFYAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
