TFIIH basal transcription factor complex helicase XPD subunit

Overview
NameTFIIH basal transcription factor complex helicase XPD subunit
Smed IDSMED30028922
Length (bp)2363
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TFIIH basal transcription factor complex helicase XPD subunit (SMED30028922) t-SNE clustered cells

Violin plots show distribution of expression levels for TFIIH basal transcription factor complex helicase XPD subunit (SMED30028922) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TFIIH basal transcription factor complex helicase XPD subunit (SMED30028922) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TFIIH basal transcription factor complex helicase XPD subunit (SMED30028922) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30028922

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30028922SMESG000046165.1 SmedASXL_013351SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30028922SMESG000046165.1 SmedASXL_013351SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30028922SMESG000046165.1 dd_Smed_v4_8198_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 897.501 bits (2318), Expect = 0.000e+0
Identity = 416/698 (59.60%), Postives = 542/698 (77.65%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
            +  H +LEMPSGTGKT+SLL+L+++Y + YP ++TK+IYCSRTV E+EKVI+EL+ L+N  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q D+++P C+++E FD   R+  LP GIY+L+DLK  GR+ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+     +L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  P+LHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE 731
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 895.575 bits (2313), Expect = 0.000e+0
Identity = 415/696 (59.63%), Postives = 541/696 (77.73%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFN 2219
            +  H +LEMPSGTGKT+SLL+L+++Y + YP ++TK+IYCSRTV E+EKVI+EL+ L+N  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q D+++P C+++E FD   R+  LP GIY+L+DLK  GR+ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+     +L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  P+LHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+
Sbjct:   10 AKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFH 705
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 716.842 bits (1849), Expect = 0.000e+0
Identity = 331/533 (62.10%), Postives = 419/533 (78.61%), Query Frame = 3 
Query:  627 ISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
            I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+     +L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  P+LHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:  121 ILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE 653

HSP 2 Score: 112.464 bits (280), Expect = 1.167e-30
Identity = 49/92 (53.26%), Postives = 74/92 (80.43%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCS 410
            +  H +LEMPSGTGKT+SLL+L+++Y + YP ++TK+IYCSRTV E+EKVI+EL+ L+N  E +  +K   LG+ALS+RKN+CI+ ++L+ +
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEILHAN 125

HSP 3 Score: 42.3578 bits (98), Expect = 1.167e-30
Identity = 16/28 (57.14%), Postives = 24/28 (85.71%), Query Frame = 2 
Query:   59 GLEVFFPYDYVYKEQYEYMQALKQSVDS 142
            GL V+FPYDY+Y EQ+ YM+ LK+++D+
Sbjct:    7 GLLVYFPYDYIYPEQFSYMRELKRTLDA 34
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 423.32 bits (1087), Expect = 4.417e-141
Identity = 201/380 (52.89%), Postives = 276/380 (72.63%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDG 1271
            +  H +LEMPSGTGKT+SLL+L+++Y + YP ++TK+IYCSRTV E+EKVI+EL+ L+N  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q D+++P C+++E FD   R+  LP GIY+L+DLK  GR+ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+     +L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  G
Sbjct:   10 AKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKG 389
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Human
Match: ERCC2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:HGNC Symbol;Acc:HGNC:3434])

HSP 1 Score: 320.472 bits (820), Expect = 4.667e-103
Identity = 151/282 (53.55%), Postives = 211/282 (74.82%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVL 977
            +  H +LEMPSGTGKT+SLL+L+++Y + YP ++TK+IYCSRTV E+EKVI+EL+ L+N  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q D+++P C+++E FD   R+  LP GIY+L+DLK  GR+ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+     +L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL
Sbjct:   10 AKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVL 291
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Celegans
Match: xpd-1 (XPD (Xeroderma Pigmentosum complementation group D) related [Source:UniProtKB/TrEMBL;Acc:Q9N3L2])

HSP 1 Score: 783.097 bits (2021), Expect = 0.000e+0
Identity = 369/712 (51.83%), Postives = 505/712 (70.93%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPY--GIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAISYKKV 2261
            +  H +LEMPSGTGKT+SLLSL+++YM  YP KL K++YCSRT+ E+EK ++E++ L +  E ET Q    + VA+SARKN+C+N  V     GN +D  C+ LTAS  R +   D T+  C YFE F+ +    S+P   G+++LEDL+  GR+  ICPYF  R  I+ A+I+VYSY+Y+LDPKIA LVSKD  + SVV+FDEAHNIDNVCIESMS  I++     A   L SL+ VV R K  + EKL +EY+KLV  L+     R  D  LANP LP+ +L EA+PGNIRQA+HFL F +RF+ ++  RLRT  V  E+PA F++D      I R P+RFC+ER+ +++  LEI+D     +L QV    T+VSTY  GFS+I+EP D         V+  +C D+++AI+P+++RF +VIITSGTLSP+++Y K+LD  P +  S TM+LAR C+ PL+V +G DQ+A+T++FE R D ++IRNYG+L+LE++ +VPDG+V FF SY Y+E     WY   I+ ++ K+KL+FIET DA ET+ AL  Y +AC++GRGA+L SVARGK+SEGIDF HHLGRCVIM GIP+ +T+SR+++ARL YL+D F I ENDF+ FDAMRH AQC+GRA+R KTDYGLM+ ADKR++R DKRGKLP+W+  +L+    NLS +EA Q+A+R+L  M Q F  E QL +++  K++
Sbjct:   34 ARGHGLLEMPSGTGKTVSLLSLVLAYMISYPDKLDKLVYCSRTIPEIEKCVEEMKVLYDYWEKETGQPVAKITVAMSARKNLCVNEPVAALRFGNTVDSACQKLTASSARQKRAEDPTLEACDYFENFEAK----SVPMQNGVWNLEDLRSLGREKKICPYFTARQAINRAHIVVYSYHYILDPKIAELVSKDFSRKSVVVFDEAHNIDNVCIESMSVAISQKNADRALQELQSLEGVVNRMKSSNSEKLQSEYDKLVEGLKRTERERANDERLANPVLPDQILHEAVPGNIRQANHFLLFLKRFVEYIRHRLRTHQVLIESPAAFMKDILDRMCIERKPMRFCAERLSNLVKTLEITDNGDVWALSQVTTLCTLVSTYSKGFSVIVEPQDGSQ----LAVITLSCHDASIAIRPVMSRFQSVIITSGTLSPLEMYPKVLDFDPSVIASFTMTLARPCLSPLVVARGNDQVAMTSRFEQRADVAVIRNYGNLVLEMASLVPDGMVVFFTSYLYMENVIGVWYEQHIIDELMKYKLLFIETNDALETSAALEKYVEACDSGRGAVLFSVARGKVSEGIDFSHHLGRCVIMLGIPYMYTESRVLRARLEYLRDQFGIKENDFLTFDAMRHTAQCMGRALRSKTDYGLMVFADKRFSRNDKRGKLPRWMQEYLEPACTNLSIDEAAQVARRWLTLMAQPFEKEHQLGVSLLDKEM 737
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Celegans
Match: rtel-1 (Regulator of telomere elongation helicase 1 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q93575])

HSP 1 Score: 112.464 bits (280), Expect = 3.794e-25
Identity = 83/311 (26.69%), Postives = 143/311 (45.98%), Query Frame = 3 
Query: 1326 VLHFNCMDSALAIKPILAR-FNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSD--------IQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHF--------RISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMG 2207
             + + C  ++++++ +  R    V++ SGTLSP+  +   +  + G       +L +  +   IVT+GK +  +   F+NR++   +      LL +  V+P G++ FF SY+ ++    TW ++   S+        ++K K + +E +  +E       Y +      GA LL+V RGK+SEGIDF     R VI+ GIP+       +  +  YL D          R S  D+   +A R   Q +GR +R K D+G ++L D RY    K    P+W+   +        T+       RF +E G
Sbjct:  464 TIKYFCFQASISMRMLKMRGVRNVLLASGTLSPIQAFTYNMGLNFGAILENEHALKQVPVLTSIVTRGK-RGGLAGSFQNRKNLDYVTGVAEALLRVMEVIPQGILIFFSSYSQMDELVATWKTTKWSSNSNESFWEKMEKTKRVVVEPRAKEELAAIRLRYTQGVSEQHGAALLAVCRGKVSEGIDFCDAESRAVIIIGIPYPPIHDERVVLKKMYLDDLMGRKDTKSERQSSQDWYQMEAFRAVNQAIGRVLRHKDDFGTVVLMDTRYASA-KPEMFPKWLRNTIS----RSDTDGCALKTSRFFKERG 768

HSP 2 Score: 103.219 bits (256), Expect = 2.692e-22
Identity = 87/270 (32.22%), Postives = 127/270 (47.04%), Query Frame = 3 
Query:   87 MFIKNNMNICKH*NNLSTAHCMLEMPSGTGKTISLL-SLLVSYMKQYPSK--------------------------LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDV-TCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRD---ESLPYG-IYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTI 800
            +F+KN +++      L  A   LE P+GTGKT+SLL S L    +Q  +K                          +  I Y SRT ++LE+V+ EL    N  E +   K  ILG    +R++ CIN  V      N     CRGL +   RA          C Y+  FD    D   E L  G    +ED  + G Q+ +CPYF++R     A +I+  Y Y++DPK+      DL K+S+VIFDEAHN++++C  + S  +   +I
Sbjct:   31 IFMKNVVDVLDR--KLDAA---LESPTGTGKTLSLLCSTLAWVQRQKETKPLDFATWQTSGAGGAEKTDEKLKSAYVPTIFYASRTHSQLEQVVHEL----NRTEYK-WVKTTILG----SREHFCINQKVKKIKESNRQAHVCRGLVSK--RA----------CHYYNKFDACTTDKMTEFLDKGEAMDIEDFVKLGTQNSLCPYFMSRQRSETAELILLPYNYIIDPKMRRRYKLDL-KNSIVIFDEAHNLESICESNASAELTSTSI 273
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Celegans
Match: rtel-1 (Regulator of telomere elongation helicase 1 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q93575])

HSP 1 Score: 112.464 bits (280), Expect = 3.794e-25
Identity = 83/311 (26.69%), Postives = 143/311 (45.98%), Query Frame = 3 
Query: 1326 VLHFNCMDSALAIKPILAR-FNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSD--------IQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHF--------RISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMG 2207
             + + C  ++++++ +  R    V++ SGTLSP+  +   +  + G       +L +  +   IVT+GK +  +   F+NR++   +      LL +  V+P G++ FF SY+ ++    TW ++   S+        ++K K + +E +  +E       Y +      GA LL+V RGK+SEGIDF     R VI+ GIP+       +  +  YL D          R S  D+   +A R   Q +GR +R K D+G ++L D RY    K    P+W+   +        T+       RF +E G
Sbjct:  464 TIKYFCFQASISMRMLKMRGVRNVLLASGTLSPIQAFTYNMGLNFGAILENEHALKQVPVLTSIVTRGK-RGGLAGSFQNRKNLDYVTGVAEALLRVMEVIPQGILIFFSSYSQMDELVATWKTTKWSSNSNESFWEKMEKTKRVVVEPRAKEELAAIRLRYTQGVSEQHGAALLAVCRGKVSEGIDFCDAESRAVIIIGIPYPPIHDERVVLKKMYLDDLMGRKDTKSERQSSQDWYQMEAFRAVNQAIGRVLRHKDDFGTVVLMDTRYASA-KPEMFPKWLRNTIS----RSDTDGCALKTSRFFKERG 768

HSP 2 Score: 103.219 bits (256), Expect = 2.692e-22
Identity = 87/270 (32.22%), Postives = 127/270 (47.04%), Query Frame = 3 
Query:   87 MFIKNNMNICKH*NNLSTAHCMLEMPSGTGKTISLL-SLLVSYMKQYPSK--------------------------LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDV-TCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRD---ESLPYG-IYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTI 800
            +F+KN +++      L  A   LE P+GTGKT+SLL S L    +Q  +K                          +  I Y SRT ++LE+V+ EL    N  E +   K  ILG    +R++ CIN  V      N     CRGL +   RA          C Y+  FD    D   E L  G    +ED  + G Q+ +CPYF++R     A +I+  Y Y++DPK+      DL K+S+VIFDEAHN++++C  + S  +   +I
Sbjct:   31 IFMKNVVDVLDR--KLDAA---LESPTGTGKTLSLLCSTLAWVQRQKETKPLDFATWQTSGAGGAEKTDEKLKSAYVPTIFYASRTHSQLEQVVHEL----NRTEYK-WVKTTILG----SREHFCINQKVKKIKESNRQAHVCRGLVSK--RA----------CHYYNKFDACTTDKMTEFLDKGEAMDIEDFVKLGTQNSLCPYFMSRQRSETAELILLPYNYIIDPKMRRRYKLDL-KNSIVIFDEAHNLESICESNASAELTSTSI 273
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Celegans
Match: chl-1 (ATP-dependent DNA helicase chl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21489])

HSP 1 Score: 104.76 bits (260), Expect = 8.319e-23
Identity = 65/214 (30.37%), Postives = 103/214 (48.13%), Query Frame = 3 
Query: 1554 FENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFL 2195
            ++ R   + +R+    +  L   +P+GVV F PSY +L          GI+  I++ K +F E++    T+     + +A +  +GAIL +V  GK+SEGI+F   LGR VI+ G+P+    S  ++ R+ +L        N       M    Q +GRAIR + DY  + L D RY +   R KL  WI    D   + L   E ++  + F 
Sbjct:  616 YQTRGADTTLRSLATSIQALIPHIPNGVVIFVPSYDFLFNFQKKMKEFGILKRIEEKKAVFTESRQP--TSDVWDRFSRAAKTSKGAILFAVVGGKMSEGINFCDELGRAVIVIGLPYPNKTSVELRERMKFLDTQMPNGGNLLYESLCMHAVNQAIGRAIRHRRDYAAVYLFDDRYAKESTRRKLSTWIG---DRTQVKLGFGEIIRKTRSFF 824

HSP 2 Score: 54.6842 bits (130), Expect = 2.385e-7
Identity = 49/212 (23.11%), Postives = 92/212 (43.40%), Query Frame = 3 
Query:  204 VSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDS-----------TVPVCKYFEAFDIRDR-DESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTI 800
            V   ++ P K  KI Y SRT ++LE++ +EL         +T  +  I  V  ++R  +C+N +V      + I+  C  L  + +  + +V                 C+++ +  I D  +  L   +    ++ + G+    CPYF TR ++    +++  Y  LL          +L K +V++ DEAHN+ N      S  I+  ++
Sbjct:  173 VDEEEEKPLKCLKIFYASRTHSQLEQLAEEL--------AKTRFQPRI--VTCASRGTLCVNEEVKKLKLNHLINEKCMELRKNGMSEKEKVQKLEKGTTKKTKTCATSCEFYNSTQIEDVVNGVLSNKLKSTLEVSKQGKLSNGCPYFATRKSVPQCQLVLLPYQVLLHDGTRKAWGIEL-KDNVIVLDEAHNVLNTISSLYSAEISTKSL 373
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Celegans
Match: chl-1 (ATP-dependent DNA helicase chl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21489])

HSP 1 Score: 104.76 bits (260), Expect = 8.319e-23
Identity = 65/214 (30.37%), Postives = 103/214 (48.13%), Query Frame = 3 
Query: 1554 FENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFL 2195
            ++ R   + +R+    +  L   +P+GVV F PSY +L          GI+  I++ K +F E++    T+     + +A +  +GAIL +V  GK+SEGI+F   LGR VI+ G+P+    S  ++ R+ +L        N       M    Q +GRAIR + DY  + L D RY +   R KL  WI    D   + L   E ++  + F 
Sbjct:  616 YQTRGADTTLRSLATSIQALIPHIPNGVVIFVPSYDFLFNFQKKMKEFGILKRIEEKKAVFTESRQP--TSDVWDRFSRAAKTSKGAILFAVVGGKMSEGINFCDELGRAVIVIGLPYPNKTSVELRERMKFLDTQMPNGGNLLYESLCMHAVNQAIGRAIRHRRDYAAVYLFDDRYAKESTRRKLSTWIG---DRTQVKLGFGEIIRKTRSFF 824

HSP 2 Score: 54.6842 bits (130), Expect = 2.385e-7
Identity = 49/212 (23.11%), Postives = 92/212 (43.40%), Query Frame = 3 
Query:  204 VSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDS-----------TVPVCKYFEAFDIRDR-DESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTI 800
            V   ++ P K  KI Y SRT ++LE++ +EL         +T  +  I  V  ++R  +C+N +V      + I+  C  L  + +  + +V                 C+++ +  I D  +  L   +    ++ + G+    CPYF TR ++    +++  Y  LL          +L K +V++ DEAHN+ N      S  I+  ++
Sbjct:  173 VDEEEEKPLKCLKIFYASRTHSQLEQLAEEL--------AKTRFQPRI--VTCASRGTLCVNEEVKKLKLNHLINEKCMELRKNGMSEKEKVQKLEKGTTKKTKTCATSCEFYNSTQIEDVVNGVLSNKLKSTLEVSKQGKLSNGCPYFATRKSVPQCQLVLLPYQVLLHDGTRKAWGIEL-KDNVIVLDEAHNVLNTISSLYSAEISTKSL 373
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Fly
Match: Xpd (gene:FBgn0261850 transcript:FBtr0071576)

HSP 1 Score: 889.797 bits (2298), Expect = 0.000e+0
Identity = 406/705 (57.59%), Postives = 537/705 (76.17%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  HC+LEMPSGTGKT +LLSL+V+YM ++P  + K+IYCSRTV E+EKVI ELQNL+   E          G+ LS+RKNMCI+ +V     G  +D  C GLTAS++R RH++D+  P+C+YFE F +  ++ +LP G+Y ++DLKEYGR    CPYFL R  I+HA+I+VYSY+YLLDPKIA +VSK++ + S V+FDEAHNIDNVCI+SMS  INR T++ ++N+L  L  +V+  +E D  +L  EY ++V  L+ A+  R  D+ILANP LP DVL E +PGNIR ADHFL+F +RFI ++  RLR   V  E+PA FL+D ++   I R PLRFC+ER+ S+L  LEISDLT Y +L  + +FAT+VSTY  GF+IIIEPFD++TPT+  P+LHF+C+DS++A+ P+ +RF TV+ITSGTLSPMD+Y KILD  P +  S TM+LAR C+ P+IV+KG DQ+ I++KFE REDT++IRNYG LL+E++  VPDG+V FF SY YLE+   +WY  GIV  + ++KL+FIETQD  ET+ AL NY KAC+ GRGA+LL+VARGK+SEG+DFDHH GR V+MFGIP+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRA+RGKTDYG+MI ADKR++R DKR +LP+WI  HL D + NLSTEEAVQ+A+R+LR M Q F  E QL +++
Sbjct:   34 AKGHCLLEMPSGTGKTATLLSLIVAYMVEHPETVRKLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAVDGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNHLTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDVLTEVVPGNIRNADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISDLTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPTVSNPILHFSCLDSSIAMAPVFSRFQTVVITSGTLSPMDMYPKILDFDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYVKACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDYLRDQFQIRENDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRHDKRSRLPKWIQEHLVDSFCNLSTEEAVQLARRWLRRMAQPFTREDQLGISL 738
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Fly
Match: CG4078 (gene:FBgn0029798 transcript:FBtr0070807)

HSP 1 Score: 161.384 bits (407), Expect = 1.563e-40
Identity = 88/288 (30.56%), Postives = 155/288 (53.82%), Query Frame = 3 
Query: 1326 VLHFNCMDSALAIKPIL-ARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTK----------GKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYL-----KDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDD 2141
            +++F C +    ++ +L  +  +VI+TSGTL+P+          P I++ L + +A++   P IV +          G D+  + + + NR++   I + G  +L ++ +VPDG++ FFPSY  L      W +SG+ +DI   K IF+E +  D+    +  + +A  + +GA+ ++V RGK+SEG+DF    GR VI+ G+PF   +   +  +  YL     +++  +S  ++ N DA R   Q +GR IR + DYG ++L D R+    +  +L +WI  HL D
Sbjct:  453 IINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPL---------KPLIAE-LAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGD 730

HSP 2 Score: 86.6557 bits (213), Expect = 4.834e-17
Identity = 76/274 (27.74%), Postives = 121/274 (44.16%), Query Frame = 3 
Query:  144 HCM-------LEMPSGTGKTISLLSLLVSYMKQYPSK---------------------------------------LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVT--CR----GLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSA 809
            HC+       LE P+GTGKT+SLL   +++++   S+                                       + K+IY SRT ++L + ++EL+              N+  V L +R  +CI+ +V+    GN + T  C+      T SF   + +V+S             +D  +     I  +EDL + G++  ICPYF +R  +  A+I    Y YLLDPK A   +K    +++VI DEAHNI+ +C ES S  I  + +  A
Sbjct:   30 HCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKRTAY---------ANMRSVVLGSRDQLCIHPEVMR-EQGNSNKTNMCKLRVHSKTCSF---QMRVESR------------KDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPK-ARKANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAMA 277
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Fly
Match: CG4078 (gene:FBgn0029798 transcript:FBtr0332398)

HSP 1 Score: 161.384 bits (407), Expect = 1.563e-40
Identity = 88/288 (30.56%), Postives = 155/288 (53.82%), Query Frame = 3 
Query: 1326 VLHFNCMDSALAIKPIL-ARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTK----------GKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYL-----KDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDD 2141
            +++F C +    ++ +L  +  +VI+TSGTL+P+          P I++ L + +A++   P IV +          G D+  + + + NR++   I + G  +L ++ +VPDG++ FFPSY  L      W +SG+ +DI   K IF+E +  D+    +  + +A  + +GA+ ++V RGK+SEG+DF    GR VI+ G+PF   +   +  +  YL     +++  +S  ++ N DA R   Q +GR IR + DYG ++L D R+    +  +L +WI  HL D
Sbjct:  453 IINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPL---------KPLIAE-LAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTRENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQLSKWIRGHLGD 730

HSP 2 Score: 86.6557 bits (213), Expect = 4.834e-17
Identity = 76/274 (27.74%), Postives = 121/274 (44.16%), Query Frame = 3 
Query:  144 HCM-------LEMPSGTGKTISLLSLLVSYMKQYPSK---------------------------------------LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVT--CR----GLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSA 809
            HC+       LE P+GTGKT+SLL   +++++   S+                                       + K+IY SRT ++L + ++EL+              N+  V L +R  +CI+ +V+    GN + T  C+      T SF   + +V+S             +D  +     I  +EDL + G++  ICPYF +R  +  A+I    Y YLLDPK A   +K    +++VI DEAHNI+ +C ES S  I  + +  A
Sbjct:   30 HCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKRTAY---------ANMRSVVLGSRDQLCIHPEVMR-EQGNSNKTNMCKLRVHSKTCSF---QMRVESR------------KDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPK-ARKANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAMA 277
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Fly
Match: CG11403 (gene:FBgn0026876 transcript:FBtr0070245)

HSP 1 Score: 151.754 bits (382), Expect = 1.667e-37
Identity = 96/308 (31.17%), Postives = 153/308 (49.68%), Query Frame = 3 
Query: 1230 VANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKIL--DCHPG-ISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACEN--GRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRI-SENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHL 2135
            +A   T+ S   DG  I+++P            L +  +D A     I+A    ++I  GT+ P    ++ L   CH   + +     +A + I P +++ G     ++ KF +R    ++R    +L  L  VVP GVV F PSY YL+  +     SG +  I   K +F E   + E    L NY  A +     GA+LLSV  GK+SEG++F   LGR V++ G+P+  + S  ++ R+ +L +     + N++     ++   QC+GRA+R   DY  + L DKR+  P  RGKLP+WIS H+
Sbjct:  541 LAFLETLTSNAEDG-RILVDPVG--------GTLKYILLDPAEQFADIVAEARAIVIAGGTMQPTKELKEQLFTGCHDRLVERFYNHVVANDAILPFVISNGPSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVPGGVVCFLPSYEYLDKVYKYLEQSGTLETISGRKSVFREVSGSAEQ--LLDNYALAIKRPASYGALLLSVVGGKLSEGLNFADDLGRAVLVVGLPYSNSLSPELRQRMQHLDEKLGPGAGNEYYENLCVKAVNQCIGRAVRHIKDYACVYLLDKRFADPKIRGKLPKWISRHI 837

HSP 2 Score: 53.9138 bits (128), Expect = 5.028e-7
Identity = 52/208 (25.00%), Postives = 91/208 (43.75%), Query Frame = 3 
Query:  240 KIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSS-GNIDVTCRGLTASFVRAR--------HQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKD 836
            +I +CSRT ++L +++ EL+        +T    ++  ++L +R+ +C N  V      G ++  C  +     R           + +S  P         +RD   + P  I   E+L   G   G C Y+ +R+ + HA +I+  Y  LL     N +   L K S+VI DEAHN+ +   +     I+R  ++ A   +   KD
Sbjct:  189 QIFFCSRTHSQLAQIVAELR--------KTPHGQSVRSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSRLTAEANSRCPFKAASLVESLRDLALTEPLDI---EELANEGTACGGCSYYASRSAVEHAQLILLPYQLLLQKSARNQLGISL-KGSIVIVDEAHNLLDSVAQLHGSEISRQQLERAKVQISGYKD 384
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Zebrafish
Match: ercc2 (excision repair cross-complementation group 2 [Source:ZFIN;Acc:ZDB-GENE-040426-997])

HSP 1 Score: 881.708 bits (2277), Expect = 0.000e+0
Identity = 411/705 (58.30%), Postives = 539/705 (76.45%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  H +LEMPSGTGKTISLLSL+V+Y K YP ++TK++YCSRTV E+EKV++EL+ L++    +T  K + L +ALS+RKN+CI+ +V +   G  +D  C  LTAS++RA+HQ +   PVC+++E FD   R   +P GIY+L+DLK++GR+ G CPYFL R  + HANI+VYSY+YLLDPKIA+LVSK+L K SVV+FDEAHNIDNVCI+SMS  I R T+     ++ +L++ + R KE D  KL  EY +LV  L+ AN AR  D+ L+NP LP+++L EA+PG+IR A+HF+ F +RF+ ++  RLR   V  E+   FL+D      I R PLRFC+ER++S+L  LEI+D+  +  +  +++FAT+VSTY  GF+IIIEPF+++TPTI  PVLHF+CMD ++AIKP+  RF TVIITSGTLSP+DIY +ILD  P    S TM+LAR C+ PLIV +G DQ+A+T+KFE RED ++IRNYG+LLLE+S +VPDG+VAFF SY Y+E    +WY  GI+ +IQ++KLIFIETQDA ET++AL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLMI ADKRY R DKRGKLP+WI  HL D  LNL+ +E VQ++K FLR+M Q F  E QL L++
Sbjct:   34 AKGHGVLEMPSGTGKTISLLSLIVAYQKTYPLEVTKLVYCSRTVPEIEKVVEELRKLMDYYSKQTGVKNDFLALALSSRKNLCIHPEVSSLRFGKEVDGKCHSLTASYIRAQHQSNPNQPVCQFYEEFDNVGRQVPIPPGIYNLDDLKDFGRRKGWCPYFLARYALLHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNVETLQNTISRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEILQEAVPGSIRTAEHFVGFMKRFLEYLKARLRIHHVVQESAPQFLKDIFEKVCIDRKPLRFCAERLRSLLRTLEIADIADFSPITLISHFATLVSTYSKGFTIIIEPFEDKTPTIANPVLHFSCMDPSIAIKPVFGRFQTVIITSGTLSPLDIYPRILDFRPVTMASFTMTLARTCLCPLIVGRGNDQVAMTSKFETREDFAVIRNYGNLLLEMSAIVPDGIVAFFTSYMYMENIVASWYEQGILENIQRNKLIFIETQDAAETSMALEKYQEACENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADKRGKLPRWIQEHLTDGSLNLTIDETVQLSKHFLRQMAQPFRREDQLGLSL 738
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Zebrafish
Match: rtel1 (regulator of telomere elongation helicase 1 [Source:NCBI gene;Acc:503732])

HSP 1 Score: 218.009 bits (554), Expect = 1.140e-58
Identity = 189/731 (25.85%), Postives = 326/731 (44.60%), Query Frame = 3 
Query:  150 MLEMPSGTGKTISLLSLLVSYMKQ---------------------------------------YPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDV-TCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYN--KLVANLR--IANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRF-IAFVDCRLRTSAVRY---------ETPAVFLRDCAAN--AGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQV--ANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILAR-FNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACE--NGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFR--------ISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHL 2135
            +LE P+GTGKT+ LL   +++                                          Y + + KIIY SRT ++L +V+ EL+N     +I            L +R+ +CIN +V+   S +I V  CR   +S              C ++   D +  D+ +   I  +EDL + G++  +CPY+L+R+   HA++I   Y YLLDPK     + +L K +VVIFDEAHN++ +C ES S  +  + + SA  ++  L  +  +  ++ K     ++N   L + L+  I   A+++ +++   T   D  + A    I +   F+  F+ F +A V+ + +T  V             P VFL        A I++  L F +E  +    +   + L  ++  +    +NF     T +   S   +  +         VL + C     +++ +L +    +I+TSGTLSP+  +   +     +S      + R+ I   I+ KG D + ++T F+ R     + + G+ L+ LS VVP G++ FFPSY  ++ T   W + G    I+  K +F+E +        +  Y    +  N  G    +V RGK SEG+DF    GR V++ G+PF       +  ++ YL +  R        ++  ++    A R   Q +GR IR + DYG + L D R+   D R +LP W+  ++
Sbjct:   39 VLESPTGTGKTLCLLCSTLAWRDHFKDTISARKITERMGGAELFADRPMSSWGTAATDGDTPTYYTDIPKIIYASRTHSQLTQVVNELKNTSYRPKI----------CVLGSREQLCINQEVMRHESNHIKVHMCRAKVSSRS------------CIFYNNVDEKSTDKEIVNSILDVEDLVKTGKKQRVCPYYLSRSLKQHADVIFMPYNYLLDPKSRRAHNIEL-KGAVVIFDEAHNVEKMCEESTSFDLTPHDLISAIEAVDRL--LREQASDISKADSAEDFNVESLNSGLKMDITTIAKVKQILMDLETAINDFEMPANNQGITKPGSFI--FELFEMANVNSKTKTETVEAMEQITGYLAGRPGVFLNTSGLQKVADIIQ--LVFVAEPAEGSKKSQTGNSLKEFKVHIHPDNSNFKKKQITDVWASSSTKKQGN---------VLSYWCFSPGFSMQELLRQEVRCIILTSGTLSPLSSFTCEMQIPFPVSLENPHVIQRDQIFVSIIEKGPDGVQLSTAFDRRFVPENMSSMGNTLVNLSRVVPHGLLVFFPSYPVMDKTLEFWRAKGHADRIENVKPMFVEPRGKGTFTEVIDGYYGKVDDPNSSGGSFFAVCRGKASEGLDFADTYGRGVVITGLPFPPRMDPRVVLKMQYLDEMCRNKISGVKYLTGQEWYRQQASRAVNQAIGRVIRHREDYGAIFLCDHRFKSADARNQLPSWVRPYV 731
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Zebrafish
Match: ddx11 (DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 [Source:NCBI gene;Acc:492353])

HSP 1 Score: 195.667 bits (496), Expect = 7.234e-52
Identity = 188/713 (26.37%), Postives = 309/713 (43.34%), Query Frame = 3 
Query:  234 LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVT---CRGLTASFVRARHQVDST--------VPVCKYFEAFD--IRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVR---RTKELDK-EKLTNEYNKLVANL--RIANEARMEDLILANPTLP-EDVLIEAIPGNIRQADHFLNFF--QRFI--AFVDCRLRTSAVRYETPAVFLRDCAANA------GILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVAN---FATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLA------RNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKA---CEN---GR-GAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHF-----RISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWI--STHLDDMYLNLSTEEAVQMAKRFLREMGQE 2213
            +TKI YCSRT ++L + + E+Q        ++     +  V L +R+N+CIN +V+    GN+ +    C  +  +    R +   +              F  F+  +  +DE L   +  +E L ++GR+   CPY+ TR +I  A ++V  Y  LL           L K  +VI DEAHN+ +      S  I+   +  A + L    +  R   + K L   +++      LV  L  ++      +     +  L   D L +A   NI       N F  Q++   + +  +L   A +YE   +     + N       G+ R      S+        + + D  I  S + +A    FA + +   DG  +I     +R   +    L F  +++A+    IL     VII  GT+ P+  +++ L    G+++   +  +         I P+++  G     +   F+ R+   ++   G +L  L  +VP GVV FFPSY Y +     W S+GI+  +Q  K IF E + A +    L  Y K    C N   G+ GA+L SV  GK+SEGI+F   LGRC++M G+P+   +S  ++ ++ YL  H      +      +    M+   Q +GRAIR + DY  ++L D RY R     KLP+WI  STH    +       A   A+RF  E  Q+
Sbjct:  176 VTKIYYCSRTHSQLAQFVHEVQ--------KSPYGDAVRLVNLGSRQNLCINPEVVRL--GNVQMMNERCLEMQKNKHEKRQKASDSESKRSRGLAKATCVFSRFENLMAMKDEVL-VKVRDVEQLIQHGRETHTCPYYSTRMSIPAAQVVVLPYQSLLHASTRKASGIKL-KDQIVIIDEAHNLMDTISAIHSAEISGGQLCRAHSQLSQYCERYRSRLKAKNLMYIKQILFVLEGLVRTLGGKVGQNPNTQSCQTGSELLTINDFLFKAQVDNI-------NLFKVQKYFEKSMISRKLCGFAEKYEGSGINTHSSSKNKENRRTEGLGRFLQTLQSKPTDVSEQQMAVEDKPIMASPMMLAESFLFA-LTNANKDGRVVI-----QRQACVAQSSLKFLLLNAAVHFAQILQECRAVIIAGGTMQPVADFKEQLLFSAGVTEERILEFSCGHVIPPENILPIVLCAGPSGQQLEFTFQTRDSPQMMEETGRVLSNLCNIVPGGVVCFFPSYEYEKRILGHWESTGILQRLQSKKKIFQEPKKASQVEQVLSEYSKCIQRCSNIGGGQTGALLFSVVGGKMSEGINFSDDLGRCIVMVGMPYPNIKSPELQEKMAYLDKHMPHVAGKSPGKALVESLCMKAVNQSIGRAIRHRGDYACIVLCDHRYARTGTLQKLPEWIRSSTHTHATF-----GPAFASARRFFLEKRQK 858
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Zebrafish
Match: ddx11 (DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 [Source:NCBI gene;Acc:492353])

HSP 1 Score: 194.897 bits (494), Expect = 1.636e-51
Identity = 188/713 (26.37%), Postives = 309/713 (43.34%), Query Frame = 3 
Query:  234 LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVT---CRGLTASFVRARHQVDST--------VPVCKYFEAFD--IRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVR---RTKELDK-EKLTNEYNKLVANL--RIANEARMEDLILANPTLP-EDVLIEAIPGNIRQADHFLNFF--QRFI--AFVDCRLRTSAVRYETPAVFLRDCAANA------GILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVAN---FATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLA------RNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKA---CEN---GR-GAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHF-----RISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWI--STHLDDMYLNLSTEEAVQMAKRFLREMGQE 2213
            +TKI YCSRT ++L + + E+Q        ++     +  V L +R+N+CIN +V+    GN+ +    C  +  +    R +   +              F  F+  +  +DE L   +  +E L ++GR+   CPY+ TR +I  A ++V  Y  LL           L K  +VI DEAHN+ +      S  I+   +  A + L    +  R   + K L   +++      LV  L  ++      +     +  L   D L +A   NI       N F  Q++   + +  +L   A +YE   +     + N       G+ R      S+        + + D  I  S + +A    FA + +   DG  +I     +R   +    L F  +++A+    IL     VII  GT+ P+  +++ L    G+++   +  +         I P+++  G     +   F+ R+   ++   G +L  L  +VP GVV FFPSY Y +     W S+GI+  +Q  K IF E + A +    L  Y K    C N   G+ GA+L SV  GK+SEGI+F   LGRC++M G+P+   +S  ++ ++ YL  H      +      +    M+   Q +GRAIR + DY  ++L D RY R     KLP+WI  STH    +       A   A+RF  E  Q+
Sbjct:  205 VTKIYYCSRTHSQLAQFVHEVQ--------KSPYGDAVRLVNLGSRQNLCINPEVVRL--GNVQMMNERCLEMQKNKHEKRQKASDSESKRSRGLAKATCVFSRFENLMAMKDEVL-VKVRDVEQLIQHGRETHTCPYYSTRMSIPAAQVVVLPYQSLLHASTRKASGIKL-KDQIVIIDEAHNLMDTISAIHSAEISGGQLCRAHSQLSQYCERYRSRLKAKNLMYIKQILFVLEGLVRTLGGKVGQNPNTQSCQTGSELLTINDFLFKAQVDNI-------NLFKVQKYFEKSMISRKLCGFAEKYEGSGINTHSSSKNKENRRTEGLGRFLQTLQSKPTDVSEQQMAVEDKPIMASPMMLAESFLFA-LTNANKDGRVVI-----QRQACVAQSSLKFLLLNAAVHFAQILQECRAVIIAGGTMQPVADFKEQLLFSAGVTEERILEFSCGHVIPPENILPIVLCAGPSGQQLEFTFQTRDSPQMMEETGRVLSNLCNIVPGGVVCFFPSYEYEKRILGHWESTGILQRLQSKKKIFQEPKKASQVEQVLSEYSKCIQRCSNIGGGQTGALLFSVVGGKMSEGINFSDDLGRCIVMVGMPYPNIKSPELQEKMAYLDKHMPHVAGKSPGKALVESLCMKAVNQSIGRAIRHRGDYACIVLCDHRYARTGTLQKLPEWIRSSTHTHATF-----GPAFASARRFFLEKRQK 887
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Zebrafish
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:ZFIN;Acc:ZDB-GENE-081107-11])

HSP 1 Score: 150.984 bits (380), Expect = 5.245e-37
Identity = 164/695 (23.60%), Postives = 289/695 (41.58%), Query Frame = 3 
Query:  234 LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFE-AFDIRDRDE-SLPYGIYHLEDLKEYGRQHG---ICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSL-GSLKDVVRRTKELDKEK--------LTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLH---FNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNV---------ALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFR----ISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRY-NRPDKR-GKLPQWIST---HLDDMYLNLSTEEAVQMAKRFLREMGQE 2213
            + KI + +RT  ++ ++ +EL+  +            +    LS+R + C++ +V+     N +  C+     F+ A++        C+Y+     +RD+      +G++   D++E  R  G    C Y+  R  +  A I+   Y YLLDP I   +  +L K  +V+ DEAHNI++   ES S T+N+  +  A + + G +   +RR    D+ +        LTN   +    L    E R  +      T  E + I    G    AD F    +   A ++   R   V      V +   ++N   +   L    E +     N   +D   Y+  LQ +   T      D       P   R       ++H   F C++ A+A   + +   ++++TSGTLSPM  +   L     I       + ++ +    +  G     +   F++ E  +     G LLL++   V  GV+ F PSY  L+     W ++G+   +++ K +  E +   + +          A+       E   GA+L++V RGK+SEG+DF     R V+  GIPF   +   ++ ++ Y   H +    +    +    A R   Q LGR IR + D+G +IL D R+   P+K    L +W+     H D     + + E+    +R   E  +E
Sbjct:  271 IPKIFFGTRTHKQITQIARELKRTL---------YSTVPMTILSSRDHTCVHPEVV--PHANRNERCK----EFLEAKNGRS-----CRYYHNVHKMRDQSTLQWVHGLHQAWDIEELVRLGGKLRSCAYYAARELMQEACIVFCPYNYLLDPLIRESMEINL-KEQIVVLDEAHNIEDCARESASFTLNQAQLLLARDEIDGMVTHNIRR----DQHRPLLAFCCSLTNWVQESCGGL----EEREYESSCKVWTGVEVLGI--FRGLGITADTFPLLQKNLAAVLEKEERVGLVNGREETVQVPTISSNTQSMLKSLFMVLEFL--FRQNCRFAD--DYRVALQQSYMWTTQQDLPDAQGFFARPHRRRQSNRTKTLVHTLSFWCLNPAVAFSDLSSTVRSIVLTSGTLSPMGSFSSELGIKFSIQLEANHVINKSQVWVGTIGAGPQGRKLCATFQHAETFAFQDEVGALLLKVCHTVSRGVLCFLPSYKMLDKLRDRWTNTGLWDKLEECKTVITEPRGGGKGDFDELLQTYYEAIRGTAAKGEKRDGALLVAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDKHAKSRGLLPGGRWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRTNPNKYITGLSKWVRQLVRHHDTFTGAMQSLESFSQGQRGAVETFEE 930
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414])

HSP 1 Score: 870.922 bits (2249), Expect = 0.000e+0
Identity = 403/705 (57.16%), Postives = 528/705 (74.89%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  H +LEMPSGTGKT+SLLSL+V+Y + YP ++TK+IYCSRTV E+EKV++EL+ LI   + +T    N + +ALS+R+N+C+N +V     G  ID  C  LTASFVR++ Q D TV  C++FE FD   R+  LP GIY+L+DL+  GRQ G CPY+L R+ +   N++VYSY+YLLDPKIA+LVS++L K SVV+FDEAHNIDNVCI+SMS TI R T++    ++ +L   + + KE D++KL  EY +LV  LR A+ AR  D+ L+NP LP+++L EA+PG IR A HFL F +R + ++  RLR   V  E PA FLRD      I R P+RFC+ER++S+   LEI+D+T    L  + NFAT+VSTY  GF IIIEPF++RTP+I  PVLHF+C+DS+LAIKP+  RF +VIITSGTLSP+DIY KILD  P    + TM+LAR C+ P++V +G DQ+A+++KFE RED +++RNYG+LLLE+S VVPDG+V FF SY Y+E    +WY  GI+ +IQ++KLIFIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL +L+D F + ENDF+ FDAMRHAAQC+GRAIRGKTDYG+M+ ADKRY R DKRGKLP WI  HL D  LNL+ +E+V +A+ FLR+M Q F  E QL L++
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLSLIVAYQRAYPLEVTKLIYCSRTVPEIEKVVEELRKLIEYTQAQTGGTLNFMALALSSRRNLCVNPEVSALRFGKEIDGRCHSLTASFVRSQKQRDPTVQTCRFFEEFDAIGRETPLPPGIYNLDDLRTLGRQKGWCPYYLARHALGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNIETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGCIRNALHFLGFLRRLVGYIKSRLRAGHVTQEGPAAFLRDLYEKVCIERKPMRFCAERLRSLTRTLEIADITDLSPLTLITNFATLVSTYTKGFMIIIEPFEDRTPSISNPVLHFSCLDSSLAIKPVFQRFQSVIITSGTLSPLDIYPKILDFRPVTMATFTMTLARVCLCPMVVGRGNDQVAMSSKFETREDLAVMRNYGNLLLEMSAVVPDGIVGFFTSYLYMENIVASWYEQGILENIQRNKLIFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLQFLRDQFHLRENDFLTFDAMRHAAQCVGRAIRGKTDYGIMLFADKRYARSDKRGKLPLWIQEHLTDANLNLTLDESVHLARHFLRQMAQPFRREDQLGLSL 738
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414])

HSP 1 Score: 828.55 bits (2139), Expect = 0.000e+0
Identity = 389/705 (55.18%), Postives = 511/705 (72.48%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  H +LEMPSGTGKT+SLLSL+V+Y                     ++V++EL+ LI   + +T    N + +ALS+R+N+C+N +V     G  ID  C  LTASFVR++ Q D TV  C++FE FD   R+  LP GIY+L+DL+  GRQ G CPY+L R+ +   N++VYSY+YLLDPKIA+LVS++L K SVV+FDEAHNIDNVCI+SMS TI R T++    ++ +L   + + KE D++KL  EY +LV  LR A+ AR  D+ L+NP LP+++L EA+PG IR A HFL F +R + ++  RLR   V  E PA FLRD      I R P+RFC+ER++S+   LEI+D+T    L  + NFAT+VSTY  GF IIIEPF++RTP+I  PVLHF+C+DS+LAIKP+  RF +VIITSGTLSP+DIY KILD  P    + TM+LAR C+ P++V +G DQ+A+++KFE RED +++RNYG+LLLE+S VVPDG+V FF SY Y+E    +WY  GI+ +IQ++KLIFIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL +L+D F + ENDF+ FDAMRHAAQC+GRAIRGKTDYG+M+ ADKRY R DKRGKLP WI  HL D  LNL+ +E+V +A+ FLR+M Q F  E QL L++
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLSLIVAY---------------------QRVVEELRKLIEYTQAQTGGTLNFMALALSSRRNLCVNPEVSALRFGKEIDGRCHSLTASFVRSQKQRDPTVQTCRFFEEFDAIGRETPLPPGIYNLDDLRTLGRQKGWCPYYLARHALGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNIETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGCIRNALHFLGFLRRLVGYIKSRLRAGHVTQEGPAAFLRDLYEKVCIERKPMRFCAERLRSLTRTLEIADITDLSPLTLITNFATLVSTYTKGFMIIIEPFEDRTPSISNPVLHFSCLDSSLAIKPVFQRFQSVIITSGTLSPLDIYPKILDFRPVTMATFTMTLARVCLCPMVVGRGNDQVAMSSKFETREDLAVMRNYGNLLLEMSAVVPDGIVGFFTSYLYMENIVASWYEQGILENIQRNKLIFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLQFLRDQFHLRENDFLTFDAMRHAAQCVGRAIRGKTDYGIMLFADKRYARSDKRGKLPLWIQEHLTDANLNLTLDESVHLARHFLRQMAQPFRREDQLGLSL 717
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414])

HSP 1 Score: 827.78 bits (2137), Expect = 0.000e+0
Identity = 391/705 (55.46%), Postives = 514/705 (72.91%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  H +LEMPSGTGKT+SLLSL+V+Y + YP ++TK+IYCSRTV E+EKV++EL+ LI   + +T    N + +ALS+R+N+C+N +V     G  ID  C  LTASFVR++ Q D TV  C++FE FD   R+  LP GIY+L+DL+  GRQ G CPY+L R+ +   N++VYSY+YLLDPKIA+LVS++L K SVV+FDEAHNIDNVCI+SMS TI R T++    ++ +L   + + KE D++KL  EY +LV  LR A+ AR  D+ L+NP LP+++L EA+PG IR A HFL F +R + ++  RLR   V  E PA FLRD      I R P+RFC+ER++S+   LEI+D+T    L  + NFAT+VSTY  G  +          T+ F V  F C+DS+LAIKP+  RF +VIITSGTLSP+DIY KILD  P    + TM+LAR C+ P++V +G DQ+A+++KFE RED +++RNYG+LLLE+S VVPDG+V FF SY Y+E    +WY  GI+ +IQ++KLIFIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL +L+D F + ENDF+ FDAMRHAAQC+GRAIRGKTDYG+M+ ADKRY R DKRGKLP WI  HL D  LNL+ +E+V +A+ FLR+M Q F  E QL L++
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLSLIVAYQRAYPLEVTKLIYCSRTVPEIEKVVEELRKLIEYTQAQTGGTLNFMALALSSRRNLCVNPEVSALRFGKEIDGRCHSLTASFVRSQKQRDPTVQTCRFFEEFDAIGRETPLPPGIYNLDDLRTLGRQKGWCPYYLARHALGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNIETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGCIRNALHFLGFLRRLVGYIKSRLRAGHVTQEGPAAFLRDLYEKVCIERKPMRFCAERLRSLTRTLEIADITDLSPLTLITNFATLVSTYTKGIFL----------TVGFCV--FFCLDSSLAIKPVFQRFQSVIITSGTLSPLDIYPKILDFRPVTMATFTMTLARVCLCPMVVGRGNDQVAMSSKFETREDLAVMRNYGNLLLEMSAVVPDGIVGFFTSYLYMENIVASWYEQGILENIQRNKLIFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLQFLRDQFHLRENDFLTFDAMRHAAQCVGRAIRGKTDYGIMLFADKRYARSDKRGKLPLWIQEHLTDANLNLTLDESVHLARHFLRQMAQPFRREDQLGLSL 726
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414])

HSP 1 Score: 694.115 bits (1790), Expect = 0.000e+0
Identity = 318/540 (58.89%), Postives = 411/540 (76.11%), Query Frame = 3 
Query:  627 ISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +   N++VYSY+YLLDPKIA+LVS++L K SVV+FDEAHNIDNVCI+SMS TI R T++    ++ +L   + + KE D++KL  EY +LV  LR A+ AR  D+ L+NP LP+++L EA+PG IR A HFL F +R + ++  RLR   V  E PA FLRD      I R P+RFC+ER++S+   LEI+D+T    L  + NFAT+VSTY  GF IIIEPF++RTP+I  PVLHF+C+DS+LAIKP+  RF +VIITSGTLSP+DIY KILD  P    + TM+LAR C+ P++V +G DQ+A+++KFE RED +++RNYG+LLLE+S VVPDG+V FF SY Y+E    +WY  GI+ +IQ++KLIFIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL +L+D F + ENDF+ FDAMRHAAQC+GRAIRGKTDYG+M+ ADKRY R DKRGKLP WI  HL D  LNL+ +E+V +A+ FLR+M Q F  E QL L++
Sbjct:  121 LGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNIETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGCIRNALHFLGFLRRLVGYIKSRLRAGHVTQEGPAAFLRDLYEKVCIERKPMRFCAERLRSLTRTLEIADITDLSPLTLITNFATLVSTYTKGFMIIIEPFEDRTPSISNPVLHFSCLDSSLAIKPVFQRFQSVIITSGTLSPLDIYPKILDFRPVTMATFTMTLARVCLCPMVVGRGNDQVAMSSKFETREDLAVMRNYGNLLLEMSAVVPDGIVGFFTSYLYMENIVASWYEQGILENIQRNKLIFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLQFLRDQFHLRENDFLTFDAMRHAAQCVGRAIRGKTDYGIMLFADKRYARSDKRGKLPLWIQEHLTDANLNLTLDESVHLARHFLRQMAQPFRREDQLGLSL 660

HSP 2 Score: 109.768 bits (273), Expect = 4.030e-29
Identity = 47/92 (51.09%), Postives = 71/92 (77.17%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCS 410
            +  H +LEMPSGTGKT+SLLSL+V+Y + YP ++TK+IYCSRTV E+EKV++EL+ LI   + +T    N + +ALS+R+N+C+N ++  C+
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLSLIVAYQRAYPLEVTKLIYCSRTVPEIEKVVEELRKLIEYTQAQTGGTLNFMALALSSRRNLCVNPELGQCN 125

HSP 3 Score: 40.0466 bits (92), Expect = 4.030e-29
Identity = 16/28 (57.14%), Postives = 23/28 (82.14%), Query Frame = 2 
Query:   59 GLEVFFPYDYVYKEQYEYMQALKQSVDS 142
            GL V+FPY+Y+Y EQY YM  LK+++D+
Sbjct:    7 GLLVYFPYEYIYPEQYSYMLELKRTLDA 34
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Xenopus
Match: crat (carnitine O-acetyltransferase b [Source:Xenbase;Acc:XB-GENE-487012])

HSP 1 Score: 184.882 bits (468), Expect = 4.861e-48
Identity = 175/701 (24.96%), Postives = 296/701 (42.23%), Query Frame = 3 
Query:  234 LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVP----------VCKYFEAFDIRD-RDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHF------------------------LNFF--QRFI--AFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERI-------QSILHNLEISDLTIYQSLLQVANF-ATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISK------SLTMSLARNCIRPLIVTKGKDQMAITTKFENRE----DTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACEN-------GRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISEN-----DFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWIST 2129
            +TKI YCSRT ++L + + E+Q            K   L V+L +R+NMC+N DV     GN+ +          R +H+  +  P           C ++    ++  RDE+L   +  +E L    R+   CPY+ +R  I  A ++V  Y  LL           L K  VVI DEAHN+ +      S  ++   +  A + L    D  R                  + L+  N   ++ L+        +  ++ + GN++Q   F                        +N F  QR+   + +  +L     +++     L +  +    L+  L+  S++        +  L + E   L     L+Q+  F + + +   DG  I+         T+    L F  ++ A+    +L    +VII  GT+ P+  +++ L    G+S       S    +    I P+++  G     +   ++ R+    ++  +   G +L  L   VP G+V FFPSY Y +     W  SG++  +   K IF E + A++ +  L  Y K  +N         GA+L SV  GK+SEGI+F   LGRC++M G+P+   +S  ++ +++YL      +E        I    M+   Q +GRAIR + DY  ++L D RY+RP   GKLPQWI +
Sbjct:  210 VTKIYYCSRTHSQLSQFVHEVQK-------SPFGKQTRL-VSLGSRQNMCVNDDVRRL--GNVQLI-NDRCMEMQRNKHEKKNKEPERKKRQESRAACPFYSYEQMQFLRDETL-VEVKDIEQLVSLAREVKACPYYSSRYAIPTAQVVVLPYQMLLHESSRKASGIKL-KDQVVIIDEAHNLIDTITCMYSSQVSGAQLCQAHSQLMQYMDRYR------------------SRLKAKNLMYVKQLVFLL-----EKFVQVMGGNVKQNPSFQKVAQDGTTLKSINDFLFHSQIDNINLFKIQRYCTKSMISRKLSGFVEKFKGTETCLANKESQKAGLQQFLQDLSQKSRHTVGAPEGALEDAENGQLRTASPLMQIEGFLSALTNANQDGRVIL-----HMQGTVAQSSLKFLMLNPAVHFAEVLKECRSVIIAGGTMQPVSDFKQQLLISAGLSPERITEFSCGHVIPAENILPIVLCSGPTNQQLEFTYQKRDLPEMESIFMDETGRILTNLCNFVPGGLVCFFPSYEYQKRIQEHWEKSGLLKRLALKKKIFQEPKRANQVDQVLVEYSKCIKNCSQSGGAQNGALLFSVVGGKMSEGINFSDDLGRCIVMVGMPYPNIRSPELQEKMSYLDKTLPKTEGVSAGRVLIENLCMKAVNQSIGRAIRHRGDYASIVLLDHRYSRPAILGKLPQWIRS 869
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Mouse
Match: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2 [Source:MGI Symbol;Acc:MGI:95413])

HSP 1 Score: 898.271 bits (2320), Expect = 0.000e+0
Identity = 417/698 (59.74%), Postives = 543/698 (77.79%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
            +  H +LEMPSGTGKT+SLL+L+V+Y + YP ++TK+IYCSRTV E+EKVI+EL+ L++  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q D+++P C+++E FDI  R   LP GIY+L+DLK  G++ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+    ++L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  PVLHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHRE 731
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Mouse
Match: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2 [Source:MGI Symbol;Acc:MGI:95413])

HSP 1 Score: 856.67 bits (2212), Expect = 0.000e+0
Identity = 403/698 (57.74%), Postives = 526/698 (75.36%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
            +  H +LEMPSGTGKT+SLL+L+V+Y                     ++VI+EL+ L++  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q D+++P C+++E FDI  R   LP GIY+L+DLK  G++ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+    ++L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  PVLHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLALIVAY---------------------QRVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHRE 710
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Mouse
Match: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2 [Source:MGI Symbol;Acc:MGI:95413])

HSP 1 Score: 718.768 bits (1854), Expect = 0.000e+0
Identity = 332/533 (62.29%), Postives = 420/533 (78.80%), Query Frame = 3 
Query:  627 ISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
            I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+    ++L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  PVLHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:  123 ILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHRE 655

HSP 2 Score: 112.079 bits (279), Expect = 3.188e-30
Identity = 49/92 (53.26%), Postives = 74/92 (80.43%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCS 410
            +  H +LEMPSGTGKT+SLL+L+V+Y + YP ++TK+IYCSRTV E+EKVI+EL+ L++  E +  +K   LG+ALS+RKN+CI+ ++L+ +
Sbjct:   36 AKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEILHAN 127

HSP 3 Score: 40.817 bits (94), Expect = 3.188e-30
Identity = 16/28 (57.14%), Postives = 23/28 (82.14%), Query Frame = 2 
Query:   59 GLEVFFPYDYVYKEQYEYMQALKQSVDS 142
            GL V+FPYDY+Y EQ+ YM  LK+++D+
Sbjct:    9 GLLVYFPYDYIYPEQFSYMLELKRTLDA 36
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Mouse
Match: Ercc2 (excision repair cross-complementing rodent repair deficiency, complementation group 2 [Source:MGI Symbol;Acc:MGI:95413])

HSP 1 Score: 632.484 bits (1630), Expect = 0.000e+0
Identity = 293/478 (61.30%), Postives = 371/478 (77.62%), Query Frame = 3 
Query:  792 NTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
             T+    ++L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  PVLHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:    2 KTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHRE 479
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Mouse
Match: Rtel1 (regulator of telomere elongation helicase 1 [Source:MGI Symbol;Acc:MGI:2139369])

HSP 1 Score: 206.838 bits (525), Expect = 4.732e-55
Identity = 176/731 (24.08%), Postives = 325/731 (44.46%), Query Frame = 3 
Query:  150 MLEMPSGTGKTISLLSLLVSYMKQ------------------YPSK---------------------LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVT-CRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGS-LKDVVRRTK--ELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYID-GFSIIIEP-------------FDERTPTIPFPVLHFNCMDSALAIKPILAR-FNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETN--VALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFR---------ISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHL 2135
            +LE P+GTGKT+ LL   +++ +                   + S+                     + KIIY SRT ++L +VI+EL+N     ++            L +R+ +CI+ +V    S ++ ++ CR   AS              C ++   + +  ++ L   I  +EDL + G +  +CPY+L+RN    A+II   Y YLLD K     S DL K +VVIFDEAHN++ +C ES S  +    + S    +   L++  R T+  EL +E + +  +  + N+ + + A+++ ++L    L E +    +PG+ R      ++     A      +T     E+    ++  A   G+  +     +  +Q ++  ++I    ++       +  ++V   I   + + I P             +          VL + C   + +++ ++ +   T+I+TSGTL+P+  +   +     +       + +N +   IV +G D + +++ ++ R     + + G  L  ++ VVP G++ FFPSY  +E +   W   G+   ++  K +F+E ++    +  +  Y  + A     GA  L+V RGK SEG+DF    GR VI+ G+P+       +  ++ +L D  R         +S  ++    A R   Q +GR IR + DYG + L D R+   D R +LP W+  +L
Sbjct:   39 ILESPTGTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIPKIIYASRTHSQLTQVIRELRNTAYRPKV----------CVLGSREQLCIHPEVKKQESNHMQISLCRKKVASRS------------CHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDL-KGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGELQQEFIVDTSSSGL-NMELEDIAKLKMILL---RLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTN-----TAGLQKLMDIIQI----VFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRKQGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFL-DEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAQLPSWVRPYL 732
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. UniProt/SwissProt
Match: sp|O08811|ERCC2_MOUSE (General transcription and DNA repair factor IIH helicase subunit XPD OS=Mus musculus OX=10090 GN=Ercc2 PE=1 SV=2)

HSP 1 Score: 898.271 bits (2320), Expect = 0.000e+0
Identity = 417/698 (59.74%), Postives = 543/698 (77.79%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
            +  H +LEMPSGTGKT+SLL+L+V+Y + YP ++TK+IYCSRTV E+EKVI+EL+ L++  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q D+++P C+++E FDI  R   LP GIY+L+DLK  G++ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+    ++L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  PVLHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLALIVAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDIHGRQMPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASVARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPVLHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHRE 731
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. UniProt/SwissProt
Match: sp|A6QLJ0|ERCC2_BOVIN (General transcription and DNA repair factor IIH helicase subunit XPD OS=Bos taurus OX=9913 GN=ERCC2 PE=2 SV=1)

HSP 1 Score: 897.886 bits (2319), Expect = 0.000e+0
Identity = 417/698 (59.74%), Postives = 542/698 (77.65%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
            +  H +LEMPSGTGKT+SLL+L+++Y + YP ++TK+IYCSRTV E+EKVI+EL+ L++  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q DS++P C+++E FD+  R   LP GIY+L+DLK  GR+ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+     +L +L+  V R KE D+++L  EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+L+ LEISDLT +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  P+LHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQRDSSLPHCRFYEEFDVHGRQVPLPTGIYNLDDLKAVGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQANLETLQKTVLRIKETDEQRLREEYRRLVEGLREASAARETDAHLANPVLPDEVLKEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLYTLEISDLTDFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE 731
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. UniProt/SwissProt
Match: sp|P18074|ERCC2_HUMAN (General transcription and DNA repair factor IIH helicase subunit XPD OS=Homo sapiens OX=9606 GN=ERCC2 PE=1 SV=1)

HSP 1 Score: 897.501 bits (2318), Expect = 0.000e+0
Identity = 416/698 (59.60%), Postives = 542/698 (77.65%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
            +  H +LEMPSGTGKT+SLL+L+++Y + YP ++TK+IYCSRTV E+EKVI+EL+ L+N  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q D+++P C+++E FD   R+  LP GIY+L+DLK  GR+ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+     +L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  P+LHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHRE 731
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. UniProt/SwissProt
Match: sp|Q60452|ERCC2_CRIGR (General transcription and DNA repair factor IIH helicase subunit XPD OS=Cricetulus griseus OX=10029 GN=ERCC2 PE=1 SV=1)

HSP 1 Score: 895.19 bits (2312), Expect = 0.000e+0
Identity = 414/698 (59.31%), Postives = 542/698 (77.65%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSG-NIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYE 2225
            +  H +LEMPSGTGKT+SLL+L+V+Y + +P ++TK+IYCSRTV E+EKVI+EL+ L++  E +  +K   LG+ALS+RKN+CI+ +V     G ++D  C  LTAS+VRA++Q D+++P C+++E FD   R   LP GIY+L+DLK  G++ G CPYFL R +I HAN++VYSY+YLLDPKIA+LVSK+L + +VV+FDEAHNIDNVCI+SMS  + R T+    ++L +L+  V R KE D+++L +EY +LV  LR A+ AR  D  LANP LP++VL EA+PG+IR A+HFL F +R + +V  RLR   V  E+P  FL   A    I R PLRFC+ER++S+LH LEI+DL  +  L  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  P+LHF+CMD++LAIKP+  RF +VIITSGTLSP+DIY KILD HP    + TM+LAR C+ P+I+ +G DQ+AI++KFE RED ++IRNYG+LLLE+S VVPDG+VAFF SY Y+E+T  +WY  GI+ +IQ++KL+FIETQD  ET+VAL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLM+ ADKR+ R DKRGKLP+WI  HL D  LNL+ +E VQ+AK FLR+M Q F+ E
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLALIVAYQRAFPLEVTKLIYCSRTVPEIEKVIEELRKLLSFYEQQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQQDASLPHCRFYEEFDAHGRQVPLPAGIYNLDDLKALGQRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQSNLDTLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEIADLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARADKRGKLPRWIQEHLTDSNLNLTVDEGVQVAKYFLRQMAQPFHRE 731
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. UniProt/SwissProt
Match: sp|P26659|RAD15_SCHPO (General transcription and DNA repair factor IIH helicase subunit XPD OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rad15 PE=1 SV=2)

HSP 1 Score: 757.288 bits (1954), Expect = 0.000e+0
Identity = 357/707 (50.50%), Postives = 501/707 (70.86%), Query Frame = 3 
Query:  147 CMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNI-DVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAISYKKVD 2264
             +LEMPSGTGKTISLLSL+VSY + YP    K+IYCSRT++E++K + EL+ L+     +   +   LG+ L++RKN+C++  V    +GN+ D  CR LTA FVR +      VP C++ +  +  +    +  G++ L+D+ EYG +   CPYF  R  +   N+I+YSY+YLLDPKIA  VS++L K  +V+FDEAHNIDNVCIES+S  +  ++++ AS S+ SL+  V   K+ D +KL +EY KLV  L+ AN A  ED  +ANP LPEDVL EA+PGNIR+A+HF+ F +RF+ ++  R++   V  ETP  FL+       I + PLRFC+ER+ S++  L+IS +  + SL QV  FAT+V+TY  GF +I+EPF+    T+P P+L F+C+D+++AIKP+  RF +VIITSGTLSP+D+Y K+L  +  + +S  MSLARNC  P++VT+G DQ+AI++KFE R D S++RNYG++L+E S + PDG+VAFFPSY YLE+  ++W S GI+ ++ K+KLI +ET D  ET +AL  Y+ AC NGRGA+LLSVARGK+SEG+DFDHH GR VIMFGIP+ +T+SR++KARL +L+D ++I E DF+ FDAMRHAAQCLGR +RGK D+G+M+LADKRY R DKR KLP+WI  ++ +   NLST+ ++ +AK+FLR M Q F    Q    IS+  +D
Sbjct:   38 ALLEMPSGTGKTISLLSLIVSYQQHYPEH-RKLIYCSRTMSEIDKALAELKRLMAYRTSQLGYEEPFLGLGLTSRKNLCLHPSVRREKNGNVVDARCRSLTAGFVREQRLAGMDVPTCEFHDNLEDLEPHSLISNGVWTLDDITEYGEKTTRCPYFTVRRMLPFCNVIIYSYHYLLDPKIAERVSRELSKDCIVVFDEAHNIDNVCIESLSIDLTESSLRKASKSILSLEQKVNEVKQSDSKKLQDEYQKLVRGLQDANAANDEDQFMANPVLPEDVLKEAVPGNIRRAEHFIAFLKRFVEYLKTRMKVLHVIAETPTSFLQHVKDITFIDKKPLRFCAERLTSLVRALQISLVEDFHSLQQVVAFATLVATYERGFILILEPFETENATVPNPILRFSCLDASIAIKPVFERFRSVIITSGTLSPLDMYPKMLQFNTVMQESYGMSLARNCFLPMVVTRGSDQVAISSKFEARNDPSVVRNYGNILVEFSKITPDGLVAFFPSYLYLESIVSSWQSMGILDEVWKYKLILVETPDPHETTLALETYRAACSNGRGAVLLSVARGKVSEGVDFDHHYGRAVIMFGIPYQYTESRVLKARLEFLRDTYQIREADFLTFDAMRHAAQCLGRVLRGKDDHGIMVLADKRYGRSDKRTKLPKWIQQYITEGATNLSTDMSLALAKKFLRTMAQPFTASDQ--EGISWWSLD 741
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. TrEMBL
Match: T1IV49 (Helicase ATP-binding domain-containing protein OS=Strigamia maritima OX=126957 PE=4 SV=1)

HSP 1 Score: 926.006 bits (2392), Expect = 0.000e+0
Identity = 425/696 (61.06%), Postives = 549/696 (78.88%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNI-DVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFN 2219
            +  H +LEMPSGTGKTISLLSL+V+Y+K YP+ L+K++YCSRT+ E+EKVI+EL+NL+   E ET+ K NILG+ L++RKN+C++  V     G I D  C  LTA  VRARH  DS V VC ++E FD+  R+  LP G+Y+++DLKE+ R  G CPYF+ R +I HANI+VYSY+YLLDPKIA+LVSK++ K+SVV+FDEAHNIDNVCI++MS  I + T+     ++  L+  V+R KE D ++L  EY +LV  LR AN AR  D++L NP LP+D+L EA+PGNIR A+HF++F +R + ++  RLR   V  ETPA FLRD +    I R PLRFC+ER++S++  LEISDL  + ++  +ANFAT+VSTY  GF+IIIEPFD+RTPTI  PVLHF+C+DS++AIKP+  RF +VIITSGTLSP D+Y KILD  P ++ SLTM+L+R CI P+IV+KG DQ+A+TTKFE RED ++IRNYG+LL++++ +VPDGVV FF SY Y+ET   +WY  GI+ +IQ+ KL+FIETQDA ET++AL NY KACENGRGA+LLSVARGK+SEGIDFDHHLGR V+MFGIP+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRA+RGKTDYG+MI ADKR++R DKRGKLP+WI  HL D Y NLSTEEA+QM+KRFLR+M QEFN
Sbjct:   34 AKGHGILEMPSGTGKTISLLSLIVAYLKTYPANLSKLLYCSRTLPEIEKVIEELKNLLAYYEKETNVKQNILGLVLTSRKNLCVHPQVSKERDGKIVDGRCYSLTAGHVRARHTRDSGVEVCSFYEGFDLHGREFPLPSGVYNMDDLKEFSRAKGWCPYFMARYSILHANIVVYSYHYLLDPKIADLVSKEMSKTSVVVFDEAHNIDNVCIDAMSVNITKRTVDKCQTNINVLEKTVQRMKETDSQRLKTEYQRLVEGLREANVARETDVVLTNPALPDDILTEAVPGNIRTAEHFISFMKRLVEYMKTRLRVQHVVQETPASFLRDISMRVCIERKPLRFCAERLRSMIRTLEISDLADFSAISLIANFATLVSTYTKGFTIIIEPFDDRTPTISNPVLHFSCLDSSIAIKPVFDRFQSVIITSGTLSPPDMYPKILDFQPVVTTSLTMTLSRPCICPMIVSKGNDQVAMTTKFETREDIAVIRNYGNLLVDITQIVPDGVVCFFTSYLYMETVVASWYEQGIIDNIQRRKLLFIETQDAAETSLALLNYIKACENGRGAVLLSVARGKVSEGIDFDHHLGRAVVMFGIPYVYTQSRILKARLEYLRDQFQIKENDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRFSRSDKRGKLPKWIQEHLKDSYCNLSTEEAIQMSKRFLRQMAQEFN 729
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. TrEMBL
Match: A0A4S2LEP9 (Helicase ATP-binding domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_007740 PE=4 SV=1)

HSP 1 Score: 917.531 bits (2370), Expect = 0.000e+0
Identity = 425/706 (60.20%), Postives = 548/706 (77.62%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQK-CNILGVALSARKNMCINSDVLNCSSGNIDVT-CRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  H +LEMPSGTGKT+SLLSL+V+YMK  P  + K IYCSRTV E+EKV++EL+ L      ET++  C +L +ALS+RKN+CI  DV     G      C  LTASFVR +H  D++ P CK++E FD+  R++ LP GIY+L DLK YGR+HG CPYFL R +I HANIIVYSY+YLLDPKIANLVS+DLPK+SV++FDEAHNIDNVCIESMSC + R +++ A+ SL  L D V+  K+ + E+L  EY +LV  LR A  A+  D +LANP LP+++L EA+PG++R AD FL F +RF+ +V  RLR + V +ETP  FLRDC     + R PL+FC+ER++S+L+ LE++D   + SL  + NFAT+V+TY  GF +IIEPFDER+PT+  PVL+F CMD++L I+PI +RF +VIITSGTLSP+D+Y +ILD HP  S S TM+LAR+C+ P+IV+KG DQ+ +TTKFE+RED +++RNYGHLL +L+ VVPDG+VAFFPSY YLE+TF TWY   ++  IQ+HKL+F+ETQDA+ET++AL  Y +ACENGRGA+LLSVARG++SEGIDFDHHLGRCVIMFG+P+ +TQSRI KARL +L++ + I  N+FI FDAMRHAAQCLGRAIRGK+DYG+MILADKRY R DKR KLP WI + L D ++NLSTEEAVQ ++RFLR MGQ FN E QL LA+
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLSLIVAYMKARPGAIEKFIYCSRTVPEIEKVVEELKVLHKYYATETNEDGCGLLAIALSSRKNLCIERDVRRAGDGAAVDAACFRLTASFVRKKHASDASTPSCKFYEEFDLHGREQPLPCGIYNLNDLKAYGRKHGYCPYFLARYSIMHANIIVYSYFYLLDPKIANLVSRDLPKNSVIVFDEAHNIDNVCIESMSCVLTRRSLEKATTSLNRLTDRVKDVKQHNAERLKEEYRRLVEGLRQAQLAKETDQVLANPILPDEILREAVPGSLRSADSFLAFLRRFLEYVKLRLRIAHVVHETPVAFLRDCLEKVCVDRRPLQFCAERLRSLLNTLELADYAEFSSLTLLCNFATLVATYTRGFCLIIEPFDERSPTVINPVLYFYCMDASLPIRPIFSRFASVIITSGTLSPLDMYPRILDFHPVNSASFTMTLARSCVLPMIVSKGNDQVPMTTKFESREDMAVVRNYGHLLAQLASVVPDGIVAFFPSYHYLESTFATWYEQHLIEQIQRHKLLFVETQDAEETSLALAAYHRACENGRGAVLLSVARGRVSEGIDFDHHLGRCVIMFGVPYVYTQSRIFKARLDFLREQYNIQPNEFITFDAMRHAAQCLGRAIRGKSDYGIMILADKRYARADKRSKLPGWIQSQLQDAFVNLSTEEAVQASRRFLRLMGQPFNKEDQLGLAL 739
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. TrEMBL
Match: A0A3Q0KUN3 (DNA repair helicase rad3/xp-d, putative OS=Schistosoma mansoni OX=6183 PE=4 SV=1)

HSP 1 Score: 915.605 bits (2365), Expect = 0.000e+0
Identity = 424/706 (60.06%), Postives = 545/706 (77.20%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQK-CNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  H +LEMPSGTGKT+SLLSL+V+YMK  P  + K IYCSRTV ELEKVI+EL+ L      ET++K C +LG+ LS+RKN+CI  DV     G  +D  C  LTASFVR +H  D  VP CKY+E FD+  RD  LP GIY++ D+K Y ++H  CPYFLTR  IS+ANI+VYSY+YLLDPKIAN+VS++LPK+SVV+FDEAHNIDNVCIESMSC I R +++  + SL  L   V   K  + E+L  EY +LV  LR A  ++  DL+LANP LP+D+L E+IPG++R AD FL+F +RF+ +V  RLR + V +ETP  FLRDC     + R PL+FC+ER++S+LH LE++D   + SL  + NFAT+VSTY  GF +IIEPFDERTPTI  PVL+F+CMD++L I+PI++RF +VIITSGTLSP+++Y +ILD HP  + S TM+LARNC+ P+IV+KG DQ+ +TTKFE+R+D ++IRNYGHLL +LS VVPDG+VAFFPSY YLE+TF +WY   IV  IQ++KL+F+ETQDA+ET++AL  Y +ACENGRGA+LLSV RG++SEGIDFDHHLGRCVIMFG+P+ +TQSRI KARL +L++ + +  N+FI FDAMRHAAQCLGRAIRGK+DYG+MILADKRY R DKR KLP WI + L D ++NLS EE++Q ++RFLR MGQ FN   QL LA+
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLSLIVAYMKARPGIVEKFIYCSRTVPELEKVIEELKVLDKYYATETNEKGCGLLGIVLSSRKNLCIQRDVKQAGDGAAVDSACFRLTASFVRKKHMTDPNVPYCKYYEEFDLHGRDNPLPTGIYNMADIKTYAKKHNYCPYFLTRYAISYANIVVYSYFYLLDPKIANVVSRELPKNSVVVFDEAHNIDNVCIESMSCLITRRSLEKCTTSLNLLTQTVNEAKTNNSERLKEEYQRLVEGLRQAKLSKETDLVLANPALPDDILQESIPGSLRSADSFLSFLRRFLEYVKLRLRIAHVVHETPVAFLRDCLEKVCVDRKPLQFCAERLRSLLHTLELADYANFSSLTLLCNFATLVSTYTRGFCLIIEPFDERTPTIINPVLYFHCMDASLPIRPIMSRFTSVIITSGTLSPLEMYPRILDFHPVNTVSFTMTLARNCVLPMIVSKGNDQVPMTTKFESRQDVAVIRNYGHLLAQLSAVVPDGIVAFFPSYHYLESTFASWYEQHIVEQIQRNKLLFVETQDAEETSLALAAYHRACENGRGAVLLSVVRGRVSEGIDFDHHLGRCVIMFGVPYVYTQSRIFKARLDFLREQYNVRPNEFITFDAMRHAAQCLGRAIRGKSDYGIMILADKRYARADKRFKLPGWIQSQLQDAFINLSIEESIQASRRFLRLMGQPFNKNDQLGLAL 739
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. TrEMBL
Match: A7RNX6 (Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g180316 PE=4 SV=1)

HSP 1 Score: 914.45 bits (2362), Expect = 0.000e+0
Identity = 422/705 (59.86%), Postives = 554/705 (78.58%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  HC+LEMPSGTGKT+SLLSL+V+Y+K  P +LTK+IYCSRTV E+EKV++EL+ L    E ET +K NIL +ALS+RKN+CI+ +V     G  +D  C  +TASFVR +H+ DS+VPVC ++E FD   RDE +P G Y+L+DL+++GR+ G CPYFL R  I HAN+IVYSY+Y+LDPKIA+LVSK+L K +VV+FDEAHNIDNVCI+SMS TI+R T+  +  ++ SL  V+ R K  D +KL  EYN+LV  LR A+EAR  D++L+NP LP++VL E++PGNIR+A+HF+ F +RFI ++  RLR   V  E+P  FL+       I R PLRFC+ER+ S+L  LEI ++  Y  L+ +ANFAT+VSTY  GF+IIIEPFD+RTPTIP P+LHF+CMD+++A+KP+  RF +V+ITSGTLSP+D+Y KILD  P    + TM+LAR C+ P+IV++G DQ+A+TTKFE RED ++IRNYG+LL E+S VVPDG+V FF SY Y+E+  + W+  GI+S+IQK+KL+FIET DA ET++AL+NY+KACENGRGAILLSVARGK+SEGIDFDHH GR VIMFGIP+ +TQSRI+KARL YL++ F I ENDF+ FDAMRHAAQC+GRAIRGKTDYG+M+ ADKR+++ DKRGKLP+WI  +L +   NLST+E+VQ+AKRFLR+M Q F  E QL L++
Sbjct:   10 AKGHCLLEMPSGTGKTVSLLSLIVAYLKNKPLELTKLIYCSRTVPEIEKVMEELKKLTEYYESETGEKPNILALALSSRKNLCIHPEVAGEREGKKVDGKCLSMTASFVRLKHKEDSSVPVCNFYEDFDSLGRDEKMPPGSYNLDDLRQFGRKKGWCPYFLARRAIYHANVIVYSYHYMLDPKIADLVSKELDKKAVVVFDEAHNIDNVCIDSMSVTISRRTLDRSHANVESLASVIDRIKATDAQKLREEYNRLVEGLRQASEARDTDIVLSNPVLPDEVLQESVPGNIRKAEHFVGFMRRFIEYLKTRLRIQHVVQESPMSFLQHIYQQVCIERKPLRFCAERLSSLLRTLEIPEMQDYGPLVLIANFATLVSTYNKGFNIIIEPFDDRTPTIPNPILHFSCMDASIAVKPVFDRFQSVVITSGTLSPIDMYPKILDFRPVTMATFTMTLARTCLCPMIVSRGSDQVAMTTKFEMREDLAVIRNYGNLLTEMSAVVPDGIVCFFTSYLYMESVVSLWHDQGIISNIQKNKLLFIETTDAAETSLALHNYQKACENGRGAILLSVARGKVSEGIDFDHHYGRAVIMFGIPYVYTQSRILKARLEYLREQFNIRENDFLTFDAMRHAAQCVGRAIRGKTDYGIMVFADKRFSKVDKRGKLPKWIQEYLKESLCNLSTDESVQIAKRFLRQMAQPFEREDQLGLSL 714
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. TrEMBL
Match: A0A0X3PDU9 (TFIIH basal transcription factor complex helicase XPD subunit OS=Schistocephalus solidus OX=70667 GN=ERCC2 PE=4 SV=1)

HSP 1 Score: 914.45 bits (2362), Expect = 0.000e+0
Identity = 422/706 (59.77%), Postives = 540/706 (76.49%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQK-CNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  H +LEMPSGTGKT+SLLSL+V+YMK +P+ + K IYCSRTV ELEKVI+E++ L      ET ++ C +L +ALS+RKN+CI   V     G  +D  CRGLTASF+RARHQ D +V  CK++E  D+  RDE LP GIY+L DL+ YG++H  CPYFL R+ I HANI+VYSYYYLLDPKIA+LVSKD PK++VV+FDEAHNIDNVCIESMSC I+R  +      +  L   V+  KE D  +L  EYN+LV  LR A   R  DL+L NPTLP+++L EAIPG +R AD F++F +R + +V  RLR + V +ETP  FL+DC     I R PL FCSER++S+L  LE++DL+ Y  +  + NFAT+VSTY  GF II+EPF+ER PT+  PVL+F+CMD++LAI P+  R+ +VIITSGTLSP+++Y +IL+ HP    S +M+L RNCI P+IV+KG DQ+A+TTKFE+RED ++IRNYG+LL E + +VPDG+VAFFPSY YLE+TF TWY   ++  IQ+HKL+F+ETQD DET++AL NY KACENGRGAILLSVARGKISEGIDFDHHLGRC+I+FG+P+ +TQS I KARL +L++ + +  NDFI FDAMRHAAQCLGRAIRGK+DY +++LADKRY+R DKR KLP WI + L D ++NLSTEEAVQ A+RFLR MGQ FN E QL +A+
Sbjct:   34 AKGHGVLEMPSGTGKTVSLLSLIVAYMKAHPNAVEKFIYCSRTVPELEKVIEEMKELDKYYAKETGERGCGLLAIALSSRKNLCIERSVRRVGDGAAVDAACRGLTASFIRARHQNDPSVGTCKFYEELDLHGRDEVLPTGIYNLSDLRIYGKRHNYCPYFLARHAIIHANIVVYSYYYLLDPKIASLVSKDFPKNTVVVFDEAHNIDNVCIESMSCVISRRQLDRCQTGIQKLSQRVKEVKERDASQLQQEYNRLVHGLREAANERETDLVLGNPTLPDEILREAIPGTLRSADSFISFLRRLLEYVKLRLRVAHVVHETPVAFLKDCLEKVCIDRRPLLFCSERLRSLLQTLEVADLSEYAGISLLCNFATLVSTYTRGFCIIVEPFNERAPTVVNPVLYFHCMDASLAIAPVFKRYVSVIITSGTLSPLEMYPRILNFHPANVASFSMTLTRNCICPMIVSKGSDQVAMTTKFESREDLAVIRNYGNLLAEFASIVPDGIVAFFPSYHYLESTFATWYEQNLIEKIQRHKLLFVETQDNDETSLALANYHKACENGRGAILLSVARGKISEGIDFDHHLGRCIILFGVPYVYTQSHIFKARLDFLREQYNLRPNDFITFDAMRHAAQCLGRAIRGKSDYAVLVLADKRYSRADKRCKLPGWIQSQLSDAFVNLSTEEAVQAARRFLRLMGQPFNTEDQLGVAL 739
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Cavefish
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:103044920])

HSP 1 Score: 883.634 bits (2282), Expect = 0.000e+0
Identity = 410/705 (58.16%), Postives = 540/705 (76.60%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  H +LEMPSGTGKTISLLSL+V+Y K YP ++TK+IYCSRTV E+EKV++EL+ L+     ET +K N L +ALS+RKN+CI+ +V +   G  +D  C  LTAS++RA+H  + + PVC+++E FD   R   +P GIY+L+DLK++GR+ G CPY+L R +I HANI+VYSY+YLLDPKIA+LVSK+L K SVV+FDEAHNIDNVCI+SMS  I R T+     ++ +L++ ++R KE D  KL  EY +LV  L+ AN AR  D+ L+NP LP++VL EAIPG+IR A+HF+ F +RF+ ++  RLR   V  E+   FL+D      I R PLRFC+ER++S+L  LEI+D+  +  +  +++FAT+VSTY  GF+IIIEPF+++TPTI  PVLHF+CMD ++AIKP+  RF +V+ITSGTLSP+DIY +ILD  P    S TM+LAR C+ PLIV +G DQ+A+++KFE RED ++IRNYG+LLLE+S +VPDG+VAFF SY Y+E    +WY  GI+ +IQ++KLIFIET DA ET++AL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLMI ADKRY R DKRGKLP+WI  H+ D  LNL+ +E VQ++K FLR+M Q F  E QL L++
Sbjct:   34 AKGHGVLEMPSGTGKTISLLSLIVAYQKAYPLEVTKLIYCSRTVPEIEKVVEELRKLMEFYTKETGEKNNFLALALSSRKNLCIHPEVSSLRFGKEVDGKCHSLTASYIRAQHHSNPSQPVCRFYEEFDAVGRQVPIPSGIYNLDDLKDFGRKKGWCPYYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNVDTLQNTIQRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEVLQEAIPGSIRTAEHFVGFLKRFLEYLKARLRIHHVVQESSPQFLKDIYEKVCIDRKPLRFCAERLRSLLRTLEIADIADFSPITLISHFATLVSTYSKGFTIIIEPFEDKTPTIANPVLHFSCMDPSIAIKPVFERFQSVVITSGTLSPLDIYPRILDFRPVTMASFTMTLARTCLCPLIVGRGNDQVAMSSKFETREDFAVIRNYGNLLLEMSAIVPDGIVAFFTSYVYMENIVASWYEQGILENIQRNKLIFIETPDAAETSMALEKYQEACENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADKRGKLPRWIQEHISDGSLNLTIDETVQLSKHFLRQMAQPFRREDQLGLSL 738
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Cavefish
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:103044920])

HSP 1 Score: 875.544 bits (2261), Expect = 0.000e+0
Identity = 406/695 (58.42%), Postives = 534/695 (76.83%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEF 2216
            +  H +LEMPSGTGKTISLLSL+V+Y K YP ++TK+IYCSRTV E+EKV++EL+ L+     ET +K N L +ALS+RKN+CI+ +V +   G  +D  C  LTAS++RA+H  + + PVC+++E FD   R   +P GIY+L+DLK++GR+ G CPY+L R +I HANI+VYSY+YLLDPKIA+LVSK+L K SVV+FDEAHNIDNVCI+SMS  I R T+     ++ +L++ ++R KE D  KL  EY +LV  L+ AN AR  D+ L+NP LP++VL EAIPG+IR A+HF+ F +RF+ ++  RLR   V  E+   FL+D      I R PLRFC+ER++S+L  LEI+D+  +  +  +++FAT+VSTY  GF+IIIEPF+++TPTI  PVLHF+CMD ++AIKP+  RF +V+ITSGTLSP+DIY +ILD  P    S TM+LAR C+ PLIV +G DQ+A+++KFE RED ++IRNYG+LLLE+S +VPDG+VAFF SY Y+E    +WY  GI+ +IQ++KLIFIET DA ET++AL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLMI ADKRY R DKRGKLP+WI  H+ D  LNL+ +E VQ++K FLR+M Q F
Sbjct:   10 AKGHGVLEMPSGTGKTISLLSLIVAYQKAYPLEVTKLIYCSRTVPEIEKVVEELRKLMEFYTKETGEKNNFLALALSSRKNLCIHPEVSSLRFGKEVDGKCHSLTASYIRAQHHSNPSQPVCRFYEEFDAVGRQVPIPSGIYNLDDLKDFGRKKGWCPYYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNVDTLQNTIQRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEVLQEAIPGSIRTAEHFVGFLKRFLEYLKARLRIHHVVQESSPQFLKDIYEKVCIDRKPLRFCAERLRSLLRTLEIADIADFSPITLISHFATLVSTYSKGFTIIIEPFEDKTPTIANPVLHFSCMDPSIAIKPVFERFQSVVITSGTLSPLDIYPRILDFRPVTMASFTMTLARTCLCPLIVGRGNDQVAMSSKFETREDFAVIRNYGNLLLEMSAIVPDGIVAFFTSYVYMENIVASWYEQGILENIQRNKLIFIETPDAAETSMALEKYQEACENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADKRGKLPRWIQEHISDGSLNLTIDETVQLSKHFLRQMAQPF 704
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Cavefish
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:103044920])

HSP 1 Score: 704.901 bits (1818), Expect = 0.000e+0
Identity = 325/540 (60.19%), Postives = 419/540 (77.59%), Query Frame = 3 
Query:  627 ISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            I HANI+VYSY+YLLDPKIA+LVSK+L K SVV+FDEAHNIDNVCI+SMS  I R T+     ++ +L++ ++R KE D  KL  EY +LV  L+ AN AR  D+ L+NP LP++VL EAIPG+IR A+HF+ F +RF+ ++  RLR   V  E+   FL+D      I R PLRFC+ER++S+L  LEI+D+  +  +  +++FAT+VSTY  GF+IIIEPF+++TPTI  PVLHF+CMD ++AIKP+  RF +V+ITSGTLSP+DIY +ILD  P    S TM+LAR C+ PLIV +G DQ+A+++KFE RED ++IRNYG+LLLE+S +VPDG+VAFF SY Y+E    +WY  GI+ +IQ++KLIFIET DA ET++AL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLMI ADKRY R DKRGKLP+WI  H+ D  LNL+ +E VQ++K FLR+M Q F  E QL L++
Sbjct:  104 ILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNVDTLQNTIQRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEVLQEAIPGSIRTAEHFVGFLKRFLEYLKARLRIHHVVQESSPQFLKDIYEKVCIDRKPLRFCAERLRSLLRTLEIADIADFSPITLISHFATLVSTYSKGFTIIIEPFEDKTPTIANPVLHFSCMDPSIAIKPVFERFQSVVITSGTLSPLDIYPRILDFRPVTMASFTMTLARTCLCPLIVGRGNDQVAMSSKFETREDFAVIRNYGNLLLEMSAIVPDGIVAFFTSYVYMENIVASWYEQGILENIQRNKLIFIETPDAAETSMALEKYQEACENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADKRGKLPRWIQEHISDGSLNLTIDETVQLSKHFLRQMAQPFRREDQLGLSL 643

HSP 2 Score: 114.005 bits (284), Expect = 8.719e-26
Identity = 52/92 (56.52%), Postives = 73/92 (79.35%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCS 410
            +  H +LEMPSGTGKTISLLSL+V+Y K YP ++TK+IYCSRTV E+EKV++EL+ L+     ET +K N L +ALS+RKN+CI+ ++L+ +
Sbjct:   17 AKGHGVLEMPSGTGKTISLLSLIVAYQKAYPLEVTKLIYCSRTVPEIEKVVEELRKLMEFYTKETGEKNNFLALALSSRKNLCIHPEILHAN 108
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Cavefish
Match: rtel1 (regulator of telomere elongation helicase 1 [Source:NCBI gene;Acc:103025871])

HSP 1 Score: 210.305 bits (534), Expect = 3.477e-56
Identity = 188/735 (25.58%), Postives = 330/735 (44.90%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSY---------------------------------------MKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVAN----LRIANEARME------DLILANPTLPEDVLIEAIPGN----IRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAAN--AGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQ--VANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILAR-FNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADE-TNVALYNYKKACE-NGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFR--------ISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHL 2135
            S  + +LE P+GTGKT+ LL   + +                                       +  Y + + KIIY SRT ++L +V+ EL+N     ++            L +R+ +CIN +++   S +I V          RA+    S    C ++   D +  D+ +   I  +EDL + G++  +CPY+L+R+   HA++I   Y YLLDPK     + +L K +VVIFDEAHN++ +C ES S  +    + SA +++  L  +  +  ++ K   + ++N    N    L I   A+++      +L + +  +P +      PG+    + +  H +NF  +  A V+   + +      P +FL        A I++  L F  +  +    +  ++ +  ++  +    +NF    ST +   S   +  +         VL + C     +++ +L +    +I+TSGTLSP+  +   +     +S      + ++ I   IV KG D + ++T F+ R     + + G+ ++ LS VVP G++ FFPSY  L+ T   W ++G    I+  K +F+E +     T V    Y K  +    G    +V RGK SEG+DF    GR VI+ G+PF       +  ++ YL +  R        +S  ++    A R   Q +GR IR + DYG + L D R+   D R +LP W+  ++
Sbjct:   34 SKVNGVLESPTGTGKTLCLLCATLGWREYFKDSISARKISEKMGGAELFPDRPMSSWGTAATDGDVPAYYTDIPKIIYASRTHSQLTQVVSELKNTAYRPKV----------CVLGSREQLCINQEIMKQESNHIKV-------HMCRAKVSTRS----CLFYNNVDEKSTDKDIMNSILDVEDLVKTGKKERVCPYYLSRSLKQHADLIFMPYNYLLDPKSRRAHNIEL-KGAVVIFDEAHNVEKMCEESTSFDLTPYDLTSAIDAVDKL--LREQASDIGKGDSSEDFNVESLNSGLKLDITTIAKIKQILMDLELTINSFEMPSNNQGITKPGSYIYELFEKTH-VNFDTK-TAIVEAMEQITGYLAGKPGIFLNTSGLQKVADIIQ--LVFVVDPAEGSKKSQMVNSMKQFKVHIHPDTSNFKKKQSTDVWASSSAKKQGN---------VLSYWCFCPGFSMQELLRQEVRCIILTSGTLSPLSSFTCEMQIPFPVSLENPHVIQKDQIFVSIVDKGPDGVQLSTAFDKRFVPENMASLGNTIVNLSRVVPHGLLVFFPSYPVLDKTLEFWRANGHADRIENMKPMFVEPRGKGTFTEVIDGFYDKVNDPKSNGGSFFAVCRGKASEGLDFADTYGRGVIITGLPFPPRMDPRVVLKMQYLDEMCRNKSSGMKYLSGQEWYRQQASRAVNQAIGRVIRHREDYGAIFLCDHRFKNTDVRAQLPSWVRPYV 731
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Cavefish
Match: rtel1 (regulator of telomere elongation helicase 1 [Source:NCBI gene;Acc:103025871])

HSP 1 Score: 209.92 bits (533), Expect = 3.530e-56
Identity = 188/735 (25.58%), Postives = 330/735 (44.90%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSY---------------------------------------MKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVAN----LRIANEARME------DLILANPTLPEDVLIEAIPGN----IRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAAN--AGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQ--VANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILAR-FNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADE-TNVALYNYKKACE-NGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFR--------ISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHL 2135
            S  + +LE P+GTGKT+ LL   + +                                       +  Y + + KIIY SRT ++L +V+ EL+N     ++            L +R+ +CIN +++   S +I V          RA+    S    C ++   D +  D+ +   I  +EDL + G++  +CPY+L+R+   HA++I   Y YLLDPK     + +L K +VVIFDEAHN++ +C ES S  +    + SA +++  L  +  +  ++ K   + ++N    N    L I   A+++      +L + +  +P +      PG+    + +  H +NF  +  A V+   + +      P +FL        A I++  L F  +  +    +  ++ +  ++  +    +NF    ST +   S   +  +         VL + C     +++ +L +    +I+TSGTLSP+  +   +     +S      + ++ I   IV KG D + ++T F+ R     + + G+ ++ LS VVP G++ FFPSY  L+ T   W ++G    I+  K +F+E +     T V    Y K  +    G    +V RGK SEG+DF    GR VI+ G+PF       +  ++ YL +  R        +S  ++    A R   Q +GR IR + DYG + L D R+   D R +LP W+  ++
Sbjct:   34 SKVNGVLESPTGTGKTLCLLCATLGWREYFKDSISARKISEKMGGAELFPDRPMSSWGTAATDGDVPAYYTDIPKIIYASRTHSQLTQVVSELKNTAYRPKV----------CVLGSREQLCINQEIMKQESNHIKV-------HMCRAKVSTRS----CLFYNNVDEKSTDKDIMNSILDVEDLVKTGKKERVCPYYLSRSLKQHADLIFMPYNYLLDPKSRRAHNIEL-KGAVVIFDEAHNVEKMCEESTSFDLTPYDLTSAIDAVDKL--LREQASDIGKGDSSEDFNVESLNSGLKLDITTIAKIKQILMDLELTINSFEMPSNNQGITKPGSYIYELFEKTH-VNFDTK-TAIVEAMEQITGYLAGKPGIFLNTSGLQKVADIIQ--LVFVVDPAEGSKKSQMVNSMKQFKVHIHPDTSNFKKKQSTDVWASSSAKKQGN---------VLSYWCFCPGFSMQELLRQEVRCIILTSGTLSPLSSFTCEMQIPFPVSLENPHVIQKDQIFVSIVDKGPDGVQLSTAFDKRFVPENMASLGNTIVNLSRVVPHGLLVFFPSYPVLDKTLEFWRANGHADRIENMKPMFVEPRGKGTFTEVIDGFYDKVNDPKSNGGSFFAVCRGKASEGLDFADTYGRGVIITGLPFPPRMDPRVVLKMQYLDEMCRNKSSGMKYLSGQEWYRQQASRAVNQAIGRVIRHREDYGAIFLCDHRFKNTDVRAQLPSWVRPYV 731
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Sea Lamprey
Match: ercc2 (excision repair cross-complementation group 2 [Source:ZFIN;Acc:ZDB-GENE-040426-997])

HSP 1 Score: 772.696 bits (1994), Expect = 0.000e+0
Identity = 379/716 (52.93%), Postives = 512/716 (71.51%), Query Frame = 3 
Query:  141 AHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTR-NTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVL--IEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHF--NCMDSALAIKPILARFNTVIITSGTLS-----PMDIYQK---ILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
             H +LEMPSGTGKT+SLL+L+V+Y + +P+++ K++YCSRTV E+EKVI+E++ L+   E  T +    L ++LS+RKN+CI+ +V     G  +D  C  LTAS+VR RH  D +VPVC ++E F+   R+  +P GIY L+DLKEYGRQ   CPYFL R + I HAN++VYSY+YLLDPKIA+LVSK++ K SVV+FDEAHNIDNVCI+SMS  I R T+   S ++ +L+  +++ +E D  KL  EY +LV  LR A+ AR  D+ LANP LP++VL   EA+PGN R A+HF++F +RF+ ++  RLR + V  E+   FL++      I R PLRFCSER++S+L  LEI+D+  +  L  V NFAT+VSTY +GF++IIEPF+++TPTI  P+L F  +  +  L++  +     +V +  GT +     P+D        L C  G+  +LT S  R      IV +G DQ+ +++KFE RED ++IRNYG+LLLE++ VVPDGVV FF SY Y+E+    WY  GI+ +IQ++KLIFIETQD  ET+VAL  Y +ACENGRGA+LLSVARGK+SEGIDF HH GR VIMFGIP+ +TQSRI+KARL +L+DH++I ENDF+ FDAMRHAAQC+GRAIRGKTDYG+M+ ADKRY+R DKRGKLP+WI  H+ D  LNL+ +EA+Q+ K FLR M Q F  E QL L++
Sbjct:    2 GHGVLEMPSGTGKTVSLLALIVAYQRAFPNEVQKLVYCSRTVPEIEKVIEEMKKLVAYYEKHTKEPMKFLALSLSSRKNLCIHPEVSALRFGKEVDGRCHSLTASYVRNRHSSDGSVPVCSFYEDFNTNGREVPMPPGIYSLDDLKEYGRQKHWCPYFLARYSQIMHANVVVYSYHYLLDPKIADLVSKEMSKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCSTNIETLQTTIQKIRETDATKLKEEYRRLVEGLRDASVARETDVHLANPVLPDEVLQDAEAVPGNSRNAEHFVSFLKRFVEYLKSRLRVTHVLSESTPAFLKETYDRICIDRKPLRFCSERLRSLLRTLEIADIADFSPLTLVCNFATLVSTYTNGFTLIIEPFEDKTPTILNPILRFRRHSKNQKLSVHMVNDTRASVNVPCGTRALLNRFPLDKVNTRFTALRCITGVL-ALTFSPNRGLAMK-IVARGNDQVTMSSKFETREDIAVIRNYGNLLLEMTCVVPDGVVCFFTSYHYMESIVAAWYEQGILENIQRNKLIFIETQDGAETSVALEKYHEACENGRGAVLLSVARGKVSEGIDFVHHYGRAVIMFGIPYVYTQSRILKARLEFLRDHYQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGVMVFADKRYSRADKRGKLPRWIQEHITDANLNLTIDEALQVTKHFLRLMAQPFRREDQLGLSL 715
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009331.1 (pep scaffold:Pmarinus_7.0:GL478127:7852:42501:1 gene:ENSPMAG00000008437.1 transcript:ENSPMAT00000009331.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 117.857 bits (294), Expect = 1.018e-27
Identity = 64/218 (29.36%), Postives = 110/218 (50.46%), Query Frame = 3 
Query: 1512 IVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGR--GAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLK------------DHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWI 2123
            IV KG D + + + + NR   + + + G  ++ L+ ++P+G++ FFPSYT ++     W + G+ S I++ K +F+E +       A+  +     + R   A   +V RGK+SEG+DF    GR VI+ G+PF       IK ++ +L             +   +S  ++    A R   Q +GR IR + DYG +IL D R++      +LP W+
Sbjct:   20 IVEKGPDSVQLNSAYRNRSCPAYMSSLGKTIVNLARIIPNGLLVFFPSYTVMDMCLQHWKNEGLSSKIEEIKPMFVEPKQKGLFTEAINGFYDKINDPRCSAAAFFAVCRGKVSEGLDFADANGRAVIITGLPFPPQMDPWIKLKMQFLDEMKAKRSTEMQCEFVGLSGQEWYTQQASRAVNQAIGRVIRHRHDYGAIILCDHRFSSASAVAQLPSWM 237
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Sea Lamprey
Match: RTEL1-TNFRSF6B (RTEL1-TNFRSF6B readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:44095])

HSP 1 Score: 93.9745 bits (232), Expect = 6.920e-21
Identity = 84/332 (25.30%), Postives = 148/332 (44.58%), Query Frame = 3 
Query:  150 MLEMPSGTGKTISLLSLLVSYMKQ---------------------------YPSKLT---KIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVT-CRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKEL--DKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIP--GNI-RQADHFLNFFQR 1037
            +LE P+GTGKT+ LL   +++ +                            YP  +    KIIY SRT ++L + + EL+N      +            L +R+ +CI+ DV+   S +  V  CR  T S              C Y+   ++ ++      GI  +E+L + G++H +CPYF+T+     A+II   Y YLLD K     S DL    +VIFDEAHN++ +C  + S  +    + S+ +++     +  + + L    +K   + +    ++ I + A ++ L+L    L  ++ +  +P  G+I +Q       F+R
Sbjct:   39 ILESPTGTGKTLCLLCATLAWREHQVGQHVRQREQQNSWGDDGREAEAAVTYPGGVGNIPKIIYSSRTHSQLSQAMNELKNASYKPRV----------CVLGSREQLCIHPDVVKQESNHAKVHLCRAKTTS------------RSCFYYN--NVEEKKTDFIAGIMDVEELVKKGKKHQVCPYFMTQELKHDADIIFMPYNYLLDTKSRRAHSIDL-SGKIVIFDEAHNVERLCENAASFDLTPFELASSIDAVSHFLQMKVKEEGLLGSTDKFNGDGSSTGMDVSIEDVANIKQLLL---NLEREIDLVELPRGGSITKQGSFLFELFER 342
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Sea Lamprey
Match: RTEL1-TNFRSF6B (RTEL1-TNFRSF6B readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:44095])

HSP 1 Score: 89.7373 bits (221), Expect = 1.553e-19
Identity = 86/333 (25.83%), Postives = 148/333 (44.44%), Query Frame = 3 
Query:  150 MLEMPSGTGKTISLLSLLVSYMKQ---------------------------YPS---KLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVT-CRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPY-GIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKEL--DKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIP--GNI-RQADHFLNFFQR 1037
            +LE P+GTGKT+ LL   +++ +                            YP     + KIIY SRT ++L + + EL+N      +            L +R+ +CI+ DV+   S +  V  CR  T S  R+          C Y+   +        P  GI  +E+L + G++H +CPYF+T+     A+II   Y YLLD K     S DL    +VIFDEAHN++ +C  + S  +    + S+ +++     +  + + L    +K   + +    ++ I + A ++ L+L    L  ++ +  +P  G+I +Q       F+R
Sbjct:   39 ILESPTGTGKTLCLLCATLAWREHQVGQHVRQREQQNSWGDDGREAEAAVTYPGGVGNIPKIIYSSRTHSQLSQAMNELKNASYKPRV----------CVLGSREQLCIHPDVVKQESNHAKVHLCRAKTTS--RS----------CFYYNNVEGECAVHLTPTPGIMDVEELVKKGKKHQVCPYFMTQELKHDADIIFMPYNYLLDTKSRRAHSIDL-SGKIVIFDEAHNVERLCENAASFDLTPFELASSIDAVSHFLQMKVKEEGLLGSTDKFNGDGSSTGMDVSIEDVANIKQLLL---NLEREIDLVELPRGGSITKQGSFLFELFER 345
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Sea Lamprey
Match: RTEL1-TNFRSF6B (RTEL1-TNFRSF6B readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:44095])

HSP 1 Score: 85.5001 bits (210), Expect = 2.880e-18
Identity = 72/269 (26.77%), Postives = 120/269 (44.61%), Query Frame = 3 
Query:  150 MLEMPSGTGKTISLLSLLVSYMKQYPSK-------------------------------LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYF---EAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTK 854
            +LE P+GTGKT+ LL   +++ +    +                               + KIIY SRT ++L + + EL+N      +            L +R+ +CI+ DV+   S +  V    L     RA+    +T   C Y+   E +      + L   I  +E+L + G++H +CPYF+T+     A+II   Y YLLD K     S DL    +VIFDEAHN++ +C  + S  +    + S+ +++     +  RT+
Sbjct:   39 ILESPTGTGKTLCLLCATLAWREHQVGQHVRQREQQNSCTAISWSPRNQTLPVTGGVGNIPKIIYSSRTHSQLSQAMNELKNASYKPRV----------CVLGSREQLCIHPDVVKQESNHAKVWNNRLV-HLCRAK----TTSRSCFYYNNVEVYCSLRASQRLAGRIMDVEELVKKGKKHQVCPYFMTQELKHDADIIFMPYNYLLDTKSRRAHSIDL-SGKIVIFDEAHNVERLCENAASFDLTPFELASSIDAVSHFLQMKSRTQ 291
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Yeast
Match: RAD3 (5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000000973])

HSP 1 Score: 707.983 bits (1826), Expect = 0.000e+0
Identity = 334/706 (47.31%), Postives = 494/706 (69.97%), Query Frame = 3 
Query:  141 AHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNI-DVTCRGLTASFVRARHQVD--STVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIAN-EARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
             + +LEMPSGTGKT+SLLSL ++Y   YP    KIIYCSRT++E+EK + EL+NL++    E   + +  G+ L++RKN+C++ +V     G + D  CR +T    + + + D  + V +C+Y E     + ++ LP G++  E L +Y  +  +CPYF+ R  IS  NII+YSY+YLLDPKIA  VS ++ K S+VIFDEAHNIDNVCIES+S  +  + ++ A+    +L + +   +++D +KL +EY KLV  L  A+     E+  +  P LP+D+L EAIPGNIR+A+HF++F +R I ++  R++   V  ETP  FL+       I R PLRFCSER+  ++  LE++++  + +L  +A FAT++STY +GF +IIEP++     +P P++ F C+D+++AIKP+  RF++VIITSGT+SP+D+Y ++L+    + KS  M+LA+    P+I+TKG DQ+AI+++FE R D SI+RNYG +L+E + + PDG+V FFPSY Y+E+  + W + GI+ ++ KHKLI +ET DA ET++AL  Y+KAC NGRGAILLSVARGK+SEGIDFDH  GR V+M GIPF +T+SRI+KARL ++++++RI ENDF++FDAMRHAAQCLGR +RGK DYG+M+LAD+R++R  KR +LP+WI+  L D  LNLST+ A+   K+FLR M Q  + + Q  +++
Sbjct:   36 GNSILEMPSGTGKTVSLLSLTIAYQMHYPEH-RKIIYCSRTMSEIEKALVELENLMDYRTKELGYQEDFRGLGLTSRKNLCLHPEVSKERKGTVVDEKCRRMTNGQAKRKLEEDPEANVELCEYHENLYNIEVEDYLPKGVFSFEKLLKYCEEKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERVSNEVSKDSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEVRKVDSQKLQDEYEKLVQGLHSADILTDQEEPFVETPVLPQDLLTEAIPGNIRRAEHFVSFLKRLIEYLKTRMKVLHVISETPKSFLQHLKQLTFIERKPLRFCSERLSLLVRTLEVTEVEDFTALKDIATFATLISTYEEGFLLIIEPYEIENAAVPNPIMRFTCLDASIAIKPVFERFSSVIITSGTISPLDMYPRMLNFKTVLQKSYAMTLAKKSFLPMIITKGSDQVAISSRFEIRNDPSIVRNYGSMLVEFAKITPDGMVVFFPSYLYMESIVSMWQTMGILDEVWKHKLILVETPDAQETSLALETYRKACSNGRGAILLSVARGKVSEGIDFDHQYGRTVLMIGIPFQYTESRILKARLEFMRENYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRFSR--KRSQLPKWIAQGLSDADLNLSTDMAISNTKQFLRTMAQPTDPKDQEGVSV 738
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Yeast
Match: CHL1 (Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome [Source:SGD;Acc:S000005929])

HSP 1 Score: 157.147 bits (396), Expect = 3.834e-40
Identity = 166/674 (24.63%), Postives = 291/674 (43.18%), Query Frame = 3 
Query:  240 KIIYCSRTVTELEKVIQELQ---NLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTV---PVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAF-VDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPL--IVTKGKDQMAITTKFENREDTSIIRNY-GHLLLELSMVVPD--GVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPF--FFTQSRIIKARLTYLK--------DHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFL 2195
            KI Y SRT ++L +   +L+      +  +    +K   L   L+++K +CIN  V+         T   +  +    RH  +  +      ++    D     + +   I  +EDL   G+  GICPY+ +R  +  A ++   Y YLL     + +  +L ++S+VI DEAHN+    IE++      N+I S+  SL  LK+  +         +   +NK  + L   N     +L+  N  L    LI+ I  N ++    ++    F    +D       +RY   +            L+      +E      H   +S   +   L +V+ F   ++            F E+  +I + +L     + +   + IL +   V++  GT+ PM  +  + +  P +      +L+ N + P   + T   +Q  +   FE R   S++ N+     ++LS  VP   G+VAFFPSY YL      W  +   + +   + IF E +D D+    L  Y  +   GRG++LL++  GK+SEGI+F   L R V+M G+PF   F+   I+K +    K        +    +  +F+    M+   Q +GRAIR   DY  + L D RYNRP+ R KL +W+   ++  +   +T + +   ++F 
Sbjct:  232 KIYYASRTYSQLGQFTSQLRLPSFPSSFRDKVPDEKVKYL--PLASKKQLCINPKVMKWK------TLEAINDACADLRHSKEGCIFYQNTNEWRHCPDTLALRDMIFSEIQDIEDLVPLGKSLGICPYYASREALPIAEVVTLPYQYLLSESTRSSLQINL-ENSIVIIDEAHNL----IETI------NSIYSSQISLEDLKNCHK--------GIVTYFNKFKSRLNPGNRV---NLLKLNSLLM--TLIQFIVKNFKKIGQEIDPNDMFTGSNIDTLNIHKLLRYIKVSKIAYKIDTYNQALKEEESSKNENPIKETHKKSVSSQPL---LFKVSQFLYCLTNLTSEGQF----FFEKNYSIKYMLL-----EPSKPFESILNQAKCVVLAGGTMEPMSEF--LSNLLPEVPSEDITTLSCNHVIPKENLQTYITNQPELEFTFEKRMSPSLVNNHLFQFFVDLSKAVPKKGGIVAFFPSYQYLAHVIQCWKQNDRFATLNNVRKIFYEAKDGDDI---LSGYSDSVAEGRGSLLLAIVGGKLSEGINFQDDLCRAVVMVGLPFPNIFSGELIVKRKHLAAKIMKSGGTEEEASRATKEFMENICMKAVNQSVGRAIRHANDYANIYLLDVRYNRPNFRKKLSRWVQDSINSEH---TTHQVISSTRKFF 853
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Nematostella
Match: EDO46754 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNX6])

HSP 1 Score: 914.45 bits (2362), Expect = 0.000e+0
Identity = 422/705 (59.86%), Postives = 554/705 (78.58%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  HC+LEMPSGTGKT+SLLSL+V+Y+K  P +LTK+IYCSRTV E+EKV++EL+ L    E ET +K NIL +ALS+RKN+CI+ +V     G  +D  C  +TASFVR +H+ DS+VPVC ++E FD   RDE +P G Y+L+DL+++GR+ G CPYFL R  I HAN+IVYSY+Y+LDPKIA+LVSK+L K +VV+FDEAHNIDNVCI+SMS TI+R T+  +  ++ SL  V+ R K  D +KL  EYN+LV  LR A+EAR  D++L+NP LP++VL E++PGNIR+A+HF+ F +RFI ++  RLR   V  E+P  FL+       I R PLRFC+ER+ S+L  LEI ++  Y  L+ +ANFAT+VSTY  GF+IIIEPFD+RTPTIP P+LHF+CMD+++A+KP+  RF +V+ITSGTLSP+D+Y KILD  P    + TM+LAR C+ P+IV++G DQ+A+TTKFE RED ++IRNYG+LL E+S VVPDG+V FF SY Y+E+  + W+  GI+S+IQK+KL+FIET DA ET++AL+NY+KACENGRGAILLSVARGK+SEGIDFDHH GR VIMFGIP+ +TQSRI+KARL YL++ F I ENDF+ FDAMRHAAQC+GRAIRGKTDYG+M+ ADKR+++ DKRGKLP+WI  +L +   NLST+E+VQ+AKRFLR+M Q F  E QL L++
Sbjct:   10 AKGHCLLEMPSGTGKTVSLLSLIVAYLKNKPLELTKLIYCSRTVPEIEKVMEELKKLTEYYESETGEKPNILALALSSRKNLCIHPEVAGEREGKKVDGKCLSMTASFVRLKHKEDSSVPVCNFYEDFDSLGRDEKMPPGSYNLDDLRQFGRKKGWCPYFLARRAIYHANVIVYSYHYMLDPKIADLVSKELDKKAVVVFDEAHNIDNVCIDSMSVTISRRTLDRSHANVESLASVIDRIKATDAQKLREEYNRLVEGLRQASEARDTDIVLSNPVLPDEVLQESVPGNIRKAEHFVGFMRRFIEYLKTRLRIQHVVQESPMSFLQHIYQQVCIERKPLRFCAERLSSLLRTLEIPEMQDYGPLVLIANFATLVSTYNKGFNIIIEPFDDRTPTIPNPILHFSCMDASIAVKPVFDRFQSVVITSGTLSPIDMYPKILDFRPVTMATFTMTLARTCLCPMIVSRGSDQVAMTTKFEMREDLAVIRNYGNLLTEMSAVVPDGIVCFFTSYLYMESVVSLWHDQGIISNIQKNKLLFIETTDAAETSLALHNYQKACENGRGAILLSVARGKVSEGIDFDHHYGRAVIMFGIPYVYTQSRILKARLEYLREQFNIRENDFLTFDAMRHAAQCVGRAIRGKTDYGIMVFADKRFSKVDKRGKLPKWIQEYLKESLCNLSTDESVQIAKRFLRQMAQPFEREDQLGLSL 714
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Nematostella
Match: EDO39388 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA32])

HSP 1 Score: 130.954 bits (328), Expect = 3.013e-31
Identity = 71/281 (25.27%), Postives = 141/281 (50.18%), Query Frame = 3 
Query: 1326 VLHFNCMDSALAIKPILAR-FNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENG--RGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFR--------ISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHL 2135
            ++H+ C     A+K ++++  ++VI+TSGTLSP++ +   +     I       + ++ +   +VTK  D   + + +E R     +   G+ +   +  +P+G++ FFPSY  +      W ++GI + + ++K +F E +   +    + ++     +    GA   +V RGK+SEG+DF    GR V++ G+PF       +K ++++L +  R        ++  ++    A R   Q +GR IR + D+G ++L D R+  PD   +LP W+   +
Sbjct:  453 MIHYWCFSPGHAMKDLMSQGVSSVILTSGTLSPLNSFTAEMQIPFPIRLENPHVIEKHQMMVAVVTKAPDGATLNSSYEFRSTPGYMTGLGNTIANFARTIPNGLLVFFPSYPVMNKCLEHWQNTGIWARLSQYKPMFAEPRGKGDFVQTMEDFYAKINDPSLNGATFFAVCRGKVSEGLDFSDINGRAVVITGLPFPPMMDAKVKLKMSFLDEMSRKDKSAIKGLTGREWYRQQASRAVNQAVGRVIRHRQDFGAILLCDVRFTYPDALRELPSWVKPQV 733

HSP 2 Score: 102.834 bits (255), Expect = 1.864e-22
Identity = 74/258 (28.68%), Postives = 117/258 (45.35%), Query Frame = 3 
Query:  144 HCMLEMPSGTGKTISLLSLLVSYMKQYPSKLT----------------------------------------------KIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDV-TCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMS 776
            + +LE P+GTGKT+ LL   +++ + Y + L                                               KIIY SRT ++L + +QEL+  +         + +I+G    +R+ +CINSDVL   S +  V  CR      V AR         C ++   +    + +    I  +EDL   G++H +CPY++ R   + A+II   Y YLLDPK     + D+   S+V+FDEAHN++ VC E++S
Sbjct:   35 NAVLESPTGTGKTLCLLCATLAWRQSYVANLQLQQRGLCAAKEEEDGFQKSLGNKLAEAASGTWDDSCSNKGSNFEIPKIIYASRTHSQLSQAVQELKATV------YRPRVSIIG----SREQLCINSDVLKQDSNSAKVHMCRAK----VTAR--------TCHFYNNLEGNKSNPAFTTEILDIEDLVRLGQKHKVCPYYMARELKTSADIIFMPYNYLLDPKSRKAHNLDI-SGSIVVFDEAHNLEKVCEETVS 269
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Medaka
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:101163020])

HSP 1 Score: 883.634 bits (2282), Expect = 0.000e+0
Identity = 412/705 (58.44%), Postives = 538/705 (76.31%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAI 2246
            +  H +LEMPSGTGKTISLLSL+V+Y K +P  +TK+IYCSRTV E+EKV++EL+ L+     ET +  N L +ALS+RKN+CI+ +V +   G  +D  C  LTAS++RA+   +   PVC+++E FD   R   LP GIY+L+DLK++GR+ G CPY+L R +I HANI+VYSY+YLLDPKIA+LVSK+L K SVV+FDEAHNIDNVCI+SMS  I R T+    +++ +L+  +++ K+ D  KL  EY +LV  L+ AN AR  D+ LANP LP+++L EA+PG+IR A+HFL F +RF+ ++  RLR   V  E+   FL+D      I R PLRFC+ER+QS+L  LEI+D+  + ++  ++NFAT+VSTY  GF+IIIEPFD+RTPTI  PVLHF+CMD ++AIKP+  RF +V+ITSGTLSP+DIY KILD  P    S TM+LAR C+ PLIV +G DQ+A+++KFE RED ++IRNYG+LLLE+S +VPDG+VAFF SY Y+E    +WY  GI+ +IQ++KLIFIETQDA ET++AL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLMI ADKRY R DKRGKLP+WI  H+ D  LNL+ +E VQ++K FLR+M Q F  E QL L++
Sbjct:   34 AKGHGVLEMPSGTGKTISLLSLIVAYQKAFPLDVTKLIYCSRTVPEIEKVVEELRKLMEFYAKETGEVNNFLALALSSRKNLCIHPEVSSLRFGKEVDGKCHSLTASYIRAQRHSNPDQPVCRFYEEFDAVGRQVPLPAGIYNLDDLKDFGRRKGWCPYYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQSNVETLQHTIQKIKDTDAAKLREEYRRLVEGLKEANVARETDVYLANPVLPDEILQEAVPGSIRTAEHFLGFLRRFLEYLKSRLRVHHVVQESAPQFLKDIFEKVCIDRKPLRFCAERLQSLLRTLEIADIADFSAVTLISNFATLVSTYSLGFTIIIEPFDDRTPTIANPVLHFSCMDPSIAIKPVFQRFQSVVITSGTLSPLDIYPKILDFRPVTMASFTMTLARTCLCPLIVGRGNDQVALSSKFETREDFAVIRNYGNLLLEMSAIVPDGIVAFFTSYVYMENIVASWYEQGILENIQRNKLIFIETQDAAETSMALEKYQEACENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADKRGKLPRWIQEHISDGSLNLTVDETVQLSKHFLRQMAQPFRQEDQLGLSL 738
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Medaka
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:101163020])

HSP 1 Score: 874.774 bits (2259), Expect = 0.000e+0
Identity = 409/699 (58.51%), Postives = 533/699 (76.25%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGN-IDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEK 2228
            +  H +LEMPSGTGKTISLLSL+V+Y K +P  +TK+IYCSRTV E+EKV++EL+ L+     ET +  N L +ALS+RKN+CI+ +V +   G  +D  C  LTAS++RA+   +   PVC+++E FD   R   LP GIY+L+DLK++GR+ G CPY+L R +I HANI+VYSY+YLLDPKIA+LVSK+L K SVV+FDEAHNIDNVCI+SMS  I R T+    +++ +L+  +++ K+ D  KL  EY +LV  L+ AN AR  D+ LANP LP+++L EA+PG+IR A+HFL F +RF+ ++  RLR   V  E+   FL+D      I R PLRFC+ER+QS+L  LEI+D+  + ++  ++NFAT+VSTY  GF+IIIEPFD+RTPTI  PVLHF+CMD ++AIKP+  RF +V+ITSGTLSP+DIY KILD  P    S TM+LAR C+ PLIV +G DQ+A+++KFE RED ++IRNYG+LLLE+S +VPDG+VAFF SY Y+E    +WY  GI+ +IQ++KLIFIETQDA ET++AL  Y++ACENGRGAILLSVARGK+SEGIDF HH GR VIMFG+P+ +TQSRI+KARL YL+D F+I ENDF+ FDAMRHAAQC+GRAIRGKTDYGLMI ADKRY R DKRGKLP+WI  H+ D  LNL+ +E VQ++K FLR+M Q F   K
Sbjct:   34 AKGHGVLEMPSGTGKTISLLSLIVAYQKAFPLDVTKLIYCSRTVPEIEKVVEELRKLMEFYAKETGEVNNFLALALSSRKNLCIHPEVSSLRFGKEVDGKCHSLTASYIRAQRHSNPDQPVCRFYEEFDAVGRQVPLPAGIYNLDDLKDFGRRKGWCPYYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQSNVETLQHTIQKIKDTDAAKLREEYRRLVEGLKEANVARETDVYLANPVLPDEILQEAVPGSIRTAEHFLGFLRRFLEYLKSRLRVHHVVQESAPQFLKDIFEKVCIDRKPLRFCAERLQSLLRTLEIADIADFSAVTLISNFATLVSTYSLGFTIIIEPFDDRTPTIANPVLHFSCMDPSIAIKPVFQRFQSVVITSGTLSPLDIYPKILDFRPVTMASFTMTLARTCLCPLIVGRGNDQVALSSKFETREDFAVIRNYGNLLLEMSAIVPDGIVAFFTSYVYMENIVASWYEQGILENIQRNKLIFIETQDAAETSMALEKYQEACENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADKRGKLPRWIQEHISDGSLNLTVDETVQLSKHFLRQMAQPFRQVK 732
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Medaka
Match: ddx11 (DEAD/H-box helicase 11 [Source:NCBI gene;Acc:101163814])

HSP 1 Score: 192.586 bits (488), Expect = 9.263e-51
Identity = 181/703 (25.75%), Postives = 307/703 (43.67%), Query Frame = 3 
Query:  234 LTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSS-GNIDVTCRGLTASFVR-------ARHQVDSTVPVCKYFEAFDIRD-RDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLV-------ANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQAD-----------HFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCA------ANAGILRHP---LRFCSERIQSILHNLEI-----SDLTIYQSLLQVANFATMVST-----YIDGFSIIIEPFD-------ERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLA------RNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKK-----ACENG--RGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISEND-----FINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWIST 2129
            +TKI YCSRT ++L + + E+Q      +I          V L +R+N+CIN +V    S   I+  C  +  +          A+ +      VC + +A  ++  RDE L   +Y +E L + G+    CPY+ TR  I  A ++V  Y  +L           L K  VVI DEAHN+ +    ++SC                       + EL+  +L   Y++L        + L+  N   ++ ++ A      + L+  + G + Q             H +N F  F A +D        RY   ++  R  +      A +G+  H    L   + R + +L+ L+      +  ++ Q  LQ +  A  V +      I+GF + +   +        R  T+    + F  ++ A+    +L    +VII  GT+ P+  +++ L    G+ +   +  A         I P+++  G     +   F++R+   ++   G +L  +  VVP GVV FFPSY YL      W +SG ++ +   K IF E +  ++    L  + +     A E+    GA+L SV  GK+SEGI+F   LGRCV+M G+P+   +S  ++ +++YL  H   S+        +    M+   Q +GRAIR + DY  ++L D+RY+RP    KLP WI +
Sbjct:  207 VTKIYYCSRTHSQLAQFVHEVQKSPFSKDISL--------VTLGSRQNLCINEEVRRLGSIQRINDRCMEMQKNKHEKQRPEDGAKRKRGPAKSVCPFNKASALQQMRDEVLGT-VYDIEQLIKVGKDIHSCPYYATRLAIPPAKLVVLPYQMVLHEATRRAAGVQL-KGQVVIIDEAHNLSD----TLSCI---------------------HSSELNGSQLCRAYSQLTQYADRYKSRLKAKNLMYIKQILFAI-----ERLVRVLGGKVGQNPQSQNTQAGTEMHTINNF-LFKAEIDNINWFKLQRYFEKSMISRKLSGFVEKYAGSGVTLHTQNTLNKENRRTEGLLNYLKTLKSNQNSASVPQPDLQESAEAEKVLSASPMMQIEGFFMALTNSNTDGRVLVHRQGTLSESSIKFLLLNPAVHFAEVLKECRSVIIAGGTMQPVSDFKEELLLSAGVGQERIVEFACGHVIPPENILPIVMCSGPSGQELDFTFQSRDLPCMMDETGRILSNICNVVPGGVVCFFPSYEYLRRIMCHWEASGALTRLSNKKKIFQEPKKPNQVEHVLSEFSRCIQRCAQESSGLTGALLFSVVGGKMSEGINFSDDLGRCVVMVGMPYPNIKSPELQEKMSYLDKHLPHSQGKSPGQALVENLCMKAVNQSIGRAIRHRGDYSSVVLCDRRYSRPATLSKLPAWIRS 868
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Medaka
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:NCBI gene;Acc:101173242])

HSP 1 Score: 135.961 bits (341), Expect = 3.053e-32
Identity = 92/323 (28.48%), Postives = 150/323 (46.44%), Query Frame = 3 
Query: 1269 GFSIIIEPFDERTPTIPFPVL--HFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQ-----DADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFR----ISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRY-NRPDKR-GKLPQWISTHLDDMYLNLSTEEAVQMAKRFLR 2198
            GF +   P   +T  +   +L   F C++ A+A   +     ++++TSGTLSPM  +   L     I       + ++ +    V  G     +   F++ E  +     G LLL +  V+  GV+ F PSY  L+     W ++G+   +++ K +  E +     D DE     Y+  K C+   GA+L++V RGK+SEG+DF     R V+  GIPF   +   ++ ++ Y   H +    +  + +    A R   Q LGR IR K D+G +IL D RY N P+K    L +W+   +   Y   +   A+Q  K F R
Sbjct:  587 GFLVRPRPRRRQTARVKTEILTLSFWCLNPAVAFSDLSGSVRSIVLTSGTLSPMGSFSSELGVKFSIQLEANHVINKSQVWVGTVGAGPQGKKLCATFQHTETYAFQDEVGDLLLHICKVIAKGVLCFLPSYKLLDKLRDRWSNTGLWEKLEQQKTVITEPRGGAKGDFDELLQTYYDAIKCCDERDGALLIAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDQHCKSRGLLPGHRWYEIQAYRALNQALGRCIRHKNDWGALILVDDRYGNNPNKYITGLSKWVRQLVQHHY---TFSNAMQSLKAFSR 906

HSP 2 Score: 67.3958 bits (163), Expect = 4.870e-11
Identity = 61/252 (24.21%), Postives = 118/252 (46.83%), Query Frame = 3 
Query:  126 NNLSTAHCMLEMPSGTGKT--ISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFD-IRD-----RDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSL-KDVVRRTK 854
            NN + + C + +P    +    S    +    K    ++ KI + +RT  ++ ++  EL+  +           ++    LS+R + C+N +V+     N +  C+ L    + A++        C+++     +RD     R   L +  + +EDL    ++   C Y+  R  +  A+II   Y YLLDP I   +  DL    +++ DEAHNI++   ES S T++ +++K+    L S+ K+ +RR++
Sbjct:  221 NNQAASSCCVPVPEPCSRCPCASTKDTVKEKAKDDKKRIPKIFFGTRTHKQITQIAHELKRTVY---------SSVHMTILSSRDHTCVNPEVV--PHFNRNERCKDL----LEAKNGKS-----CRFYHGVQKMRDHHTLQRVHGL-HEAWDVEDLVTVAKRLRSCSYYAARELMQGASIIFCPYNYLLDPMIRESMEIDL-AGQILVLDEAHNIEDCARESTSFTLDESSLKTCREELDSMVKNNIRRSQ 450
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Medaka
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:NCBI gene;Acc:101173242])

HSP 1 Score: 135.961 bits (341), Expect = 3.232e-32
Identity = 92/323 (28.48%), Postives = 150/323 (46.44%), Query Frame = 3 
Query: 1269 GFSIIIEPFDERTPTIPFPVL--HFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQ-----DADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFR----ISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRY-NRPDKR-GKLPQWISTHLDDMYLNLSTEEAVQMAKRFLR 2198
            GF +   P   +T  +   +L   F C++ A+A   +     ++++TSGTLSPM  +   L     I       + ++ +    V  G     +   F++ E  +     G LLL +  V+  GV+ F PSY  L+     W ++G+   +++ K +  E +     D DE     Y+  K C+   GA+L++V RGK+SEG+DF     R V+  GIPF   +   ++ ++ Y   H +    +  + +    A R   Q LGR IR K D+G +IL D RY N P+K    L +W+   +   Y   +   A+Q  K F R
Sbjct:  587 GFLVRPRPRRRQTARVKTEILTLSFWCLNPAVAFSDLSGSVRSIVLTSGTLSPMGSFSSELGVKFSIQLEANHVINKSQVWVGTVGAGPQGKKLCATFQHTETYAFQDEVGDLLLHICKVIAKGVLCFLPSYKLLDKLRDRWSNTGLWEKLEQQKTVITEPRGGAKGDFDELLQTYYDAIKCCDERDGALLIAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDQHCKSRGLLPGHRWYEIQAYRALNQALGRCIRHKNDWGALILVDDRYGNNPNKYITGLSKWVRQLVQHHY---TFSNAMQSLKAFSR 906

HSP 2 Score: 67.781 bits (164), Expect = 3.938e-11
Identity = 61/252 (24.21%), Postives = 118/252 (46.83%), Query Frame = 3 
Query:  126 NNLSTAHCMLEMPSGTGKT--ISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFD-IRD-----RDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSL-KDVVRRTK 854
            NN + + C + +P    +    S    +    K    ++ KI + +RT  ++ ++  EL+  +           ++    LS+R + C+N +V+     N +  C+ L    + A++        C+++     +RD     R   L +  + +EDL    ++   C Y+  R  +  A+II   Y YLLDP I   +  DL    +++ DEAHNI++   ES S T++ +++K+    L S+ K+ +RR++
Sbjct:  221 NNQAASSCCVPVPEPCSRCPCASTKDTVKEKAKDDKKRIPKIFFGTRTHKQITQIAHELKRTVY---------SSVHMTILSSRDHTCVNPEVV--PHFNRNERCKDL----LEAKNGKS-----CRFYHGVQKMRDHHTLQRVHGL-HEAWDVEDLVTVAKRLRSCSYYAARELMQGASIIFCPYNYLLDPMIRESMEIDL-AGQILVLDEAHNIEDCARESTSFTLDESSLKTCREELDSMVKNNIRRSQ 450
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Planmine SMEST
Match: SMESG000046165.1 (SMESG000046165.1)

HSP 1 Score: 1473.76 bits (3814), Expect = 0.000e+0
Identity = 709/710 (99.86%), Postives = 709/710 (99.86%), Query Frame = 3 
Query:  135 STAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAISYKKVD 2264
            S AHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAISYKKVD
Sbjct:   10 SEAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAISYKKVD 719
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Planmine SMEST
Match: SMESG000046165.1 (SMESG000046165.1)

HSP 1 Score: 1465.29 bits (3792), Expect = 0.000e+0
Identity = 705/705 (100.00%), Postives = 705/705 (100.00%), Query Frame = 3 
Query:  150 MLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAISYKKVD 2264
            MLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAISYKKVD
Sbjct:    1 MLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAISYKKVD 705
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Planmine SMEST
Match: SMESG000018012.1 (SMESG000018012.1)

HSP 1 Score: 212.231 bits (539), Expect = 2.124e-58
Identity = 194/738 (26.29%), Postives = 331/738 (44.85%), Query Frame = 3 
Query:  138 TAHCMLEMPSGTGKTISLLSLLVSYMKQYPSKL---------------TKIIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLVANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLT--IYQSLLQ-VANFATMVSTYIDG-------FSIII-------EPFDERTPTIPFP--------------VLHFNCMDSALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRP-----LIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACENGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTY---LKDHFR---ISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYN--RPDKRGKLPQWIST------HLDDMYLNL 2156
            + +C++E+P+G+GKTI+LL   + ++KQY S+L                KI + +RT  ++ +VI+EL+              N     LS R   C+N +VL   S  ID  C+ L    +   +++D                 ++  P   + +E +    ++  ICPYF  ++ +  A+I+   Y Y+L+P I   +  +L +++++I DEAHNI+++C E  S +I             SLKD+              +Y K++    I  ++  ED          D+L       + +    +      + + D  +       E+    L++C  +   +++     ++    I  N EI+D T  I  S +Q + +F  +V   +D        FSI+I       EP +E+  +  +               VL+  CM+  +  K I     ++I+TSGTLSP+  ++K L+C     K   +  A + ++P       +  G    A+   F      S     G +LL+ S VVP+G++ F  S+  +E     W ++G++++I+KHK IFIE +   E N  +  Y K  ++  GA+LL+V RGK SEG+DF     R VI  GIP+       +  ++ Y    K HF    +S N++ N  A R   Q LGR IR + D+G MI+ D R +   P   G L  WI        + +D+Y++L
Sbjct:   35 SENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKK---------SAYSNTRMSILSGRNLSCLNQEVL--MSKEIDQNCKDLCKK-MGCIYKID-----------------NQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNL-ENNIIILDEAHNIEDICREGASMSI-------------SLKDI--------------DYLKMLLP-HILKKSGKEDC-------QHDLLTM-----LEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNEEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADVLNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNC-----KFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSL 695
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Planmine SMEST
Match: SMESG000064419.1 (SMESG000064419.1)

HSP 1 Score: 214.927 bits (546), Expect = 4.174e-58
Identity = 200/747 (26.77%), Postives = 323/747 (43.24%), Query Frame = 3 
Query:  144 HCMLEMPSGTGKTISLLSLLVSYM----------------------KQYPSKLTK-------------IIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDV-TCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTK-------ELDKEKLTNEYNKLVANLRIAN-----EARMEDLIL---ANPTLPEDV-----LIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRY-----ETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATM-VSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILA-RFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYN-YKKACE--NGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDH-----FRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQW------ISTHLDDMYLN 2153
            + +LE P+GTGKT+ LL   +++                        QY +K+ K             IIY SRT ++L + I  L+           Q C+     +++R+ +CIN  V+N  S    +  C+    S V+ R         C ++  F+      S    I  +EDL   G++  +CPYFL+R     A+I    Y YLLD KI  L + +L K ++VIFDEAHNI+ VC +S S  +    I S    L  L + +   +       E D E  ++E   L   + +       E+    + L   AN  L  +V     L+     N     HF++  ++  +F+      +  ++     E    F++    +            E   SI  NLE      Y+  +Q    AT   +  I+  S   +  +         VL F CM +   +K +      ++I+TSGTL P++  +  +D    +    +  +  + +   + TKG D   + + +  RE  S   + G+ +L LS ++P G++  FPSY  +      W S  I + + +HK + +E QD  +  +A+   Y K  +  + +G+ILLSVARGKISEG+D   H GR VI+ G+P+       I+ ++++L D      F I    +    A R   Q +GR IR   D+G + L D+R+   D R +LP W      IS H  D   N
Sbjct:   13 NAILESPTGTGKTLCLLCAALAWQDHVKKVTTNSEDEILLHLNSNGNQYWNKVKKSQLNISKINVVPKIIYSSRTHSQLSQCINALKRT---------QYCDRKVGMIASREQLCINPKVMNLESNTAKIYGCK----SRVKTRK--------CFFYNQFEKAKEILSSETKIADIEDLLTIGKKKSVCPYFLSREMFDSADITFMPYNYLLDSKIRRLYNINL-KGNIVIFDEAHNIEQVCEDSASVQLTSINIASCIEELKVLGEFIYSIQSTDAIIDEADNESRSDEIPDLTQIIHLKQNLCILESEFHSIDLGNNANAGLTVEVNILFQLLNRCGFNHSNKLHFIDLLEKCSSFIGMSSEPTLTKHGIKGLEKVQEFMKTVFFDE---------IGEEFDSI-DNLEKKLSACYRVFIQENEIATSNRNNKINWGSNKNQAVNGDKNR----VLSFWCMTAGRTMKSLAGCEVRSIILTSGTLYPIETLKLDMDIKFEVELRNSHVINADQMMVSVCTKGADGEPLNSSYLTREKISYTNSLGNSILNLSKIIPRGLLVVFPSYGMMRKCIERWESCDIYNSMMQHKQLIVEPQDKTKFTLAMEQFYSKNSDPLSNKGSILLSVARGKISEGLDLSDHQGRGVIVVGLPYPSMMDPRIRLKMSFLDDRLKLFKFGIDGRCWYKQQAYRAVNQSIGRVIRHSRDFGAIYLFDERFATADSRFQLPLWLQSNIVISNHFGDAIRN 723
[Close]
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Planmine SMEST
Match: SMESG000064419.1 (SMESG000064419.1)

HSP 1 Score: 214.927 bits (546), Expect = 4.716e-58
Identity = 200/747 (26.77%), Postives = 323/747 (43.24%), Query Frame = 3 
Query:  144 HCMLEMPSGTGKTISLLSLLVSYM----------------------KQYPSKLTK-------------IIYCSRTVTELEKVIQELQNLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDV-TCRGLTASFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGICPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNIDNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTK-------ELDKEKLTNEYNKLVANLRIAN-----EARMEDLIL---ANPTLPEDV-----LIEAIPGNIRQADHFLNFFQRFIAFVDCRLRTSAVRY-----ETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEISDLTIYQSLLQVANFATM-VSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMDSALAIKPILA-RFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNCIRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFFPSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYN-YKKACE--NGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTYLKDH-----FRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDKRGKLPQW------ISTHLDDMYLN 2153
            + +LE P+GTGKT+ LL   +++                        QY +K+ K             IIY SRT ++L + I  L+           Q C+     +++R+ +CIN  V+N  S    +  C+    S V+ R         C ++  F+      S    I  +EDL   G++  +CPYFL+R     A+I    Y YLLD KI  L + +L K ++VIFDEAHNI+ VC +S S  +    I S    L  L + +   +       E D E  ++E   L   + +       E+    + L   AN  L  +V     L+     N     HF++  ++  +F+      +  ++     E    F++    +            E   SI  NLE      Y+  +Q    AT   +  I+  S   +  +         VL F CM +   +K +      ++I+TSGTL P++  +  +D    +    +  +  + +   + TKG D   + + +  RE  S   + G+ +L LS ++P G++  FPSY  +      W S  I + + +HK + +E QD  +  +A+   Y K  +  + +G+ILLSVARGKISEG+D   H GR VI+ G+P+       I+ ++++L D      F I    +    A R   Q +GR IR   D+G + L D+R+   D R +LP W      IS H  D   N
Sbjct:   37 NAILESPTGTGKTLCLLCAALAWQDHVKKVTTNSEDEILLHLNSNGNQYWNKVKKSQLNISKINVVPKIIYSSRTHSQLSQCINALKRT---------QYCDRKVGMIASREQLCINPKVMNLESNTAKIYGCK----SRVKTRK--------CFFYNQFEKAKEILSSETKIADIEDLLTIGKKKSVCPYFLSREMFDSADITFMPYNYLLDSKIRRLYNINL-KGNIVIFDEAHNIEQVCEDSASVQLTSINIASCIEELKVLGEFIYSIQSTDAIIDEADNESRSDEIPDLTQIIHLKQNLCILESEFHSIDLGNNANAGLTVEVNILFQLLNRCGFNHSNKLHFIDLLEKCSSFIGMSSEPTLTKHGIKGLEKVQEFMKTVFFDE---------IGEEFDSI-DNLEKKLSACYRVFIQENEIATSNRNNKINWGSNKNQAVNGDKNR----VLSFWCMTAGRTMKSLAGCEVRSIILTSGTLYPIETLKLDMDIKFEVELRNSHVINADQMMVSVCTKGADGEPLNSSYLTREKISYTNSLGNSILNLSKIIPRGLLVVFPSYGMMRKCIERWESCDIYNSMMQHKQLIVEPQDKTKFTLAMEQFYSKNSDPLSNKGSILLSVARGKISEGLDLSDHQGRGVIVVGLPYPSMMDPRIRLKMSFLDDRLKLFKFGIDGRCWYKQQAYRAVNQSIGRVIRHSRDFGAIYLFDERFATADSRFQLPLWLQSNIVISNHFGDAIRN 747
The following BLAST results are available for this feature:
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ERCC20.000e+059.60ERCC excision repair 2, TFIIH core complex helicas... [more]
ERCC20.000e+059.63ERCC excision repair 2, TFIIH core complex helicas... [more]
ERCC21.167e-3062.10ERCC excision repair 2, TFIIH core complex helicas... [more]
ERCC24.417e-14152.89ERCC excision repair 2, TFIIH core complex helicas... [more]
ERCC24.667e-10353.55ERCC excision repair 2, TFIIH core complex helicas... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
xpd-10.000e+051.83XPD (Xeroderma Pigmentosum complementation group D... [more]
rtel-13.794e-2526.69Regulator of telomere elongation helicase 1 homolo... [more]
rtel-13.794e-2526.69Regulator of telomere elongation helicase 1 homolo... [more]
chl-18.319e-2330.37ATP-dependent DNA helicase chl-1 [Source:UniProtK... [more]
chl-18.319e-2330.37ATP-dependent DNA helicase chl-1 [Source:UniProtK... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Xpd0.000e+057.59gene:FBgn0261850 transcript:FBtr0071576[more]
CG40781.563e-4030.56gene:FBgn0029798 transcript:FBtr0070807[more]
CG40781.563e-4030.56gene:FBgn0029798 transcript:FBtr0332398[more]
CG114031.667e-3731.17gene:FBgn0026876 transcript:FBtr0070245[more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ercc20.000e+058.30excision repair cross-complementation group 2 [Sou... [more]
rtel11.140e-5825.85regulator of telomere elongation helicase 1 [Sourc... [more]
ddx117.234e-5226.37DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 [Sour... [more]
ddx111.636e-5126.37DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 [Sour... [more]
brip15.245e-3723.60BRCA1 interacting protein C-terminal helicase 1 [S... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ephx30.000e+057.16epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-59... [more]
ephx30.000e+055.18epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-59... [more]
ephx30.000e+055.46epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-59... [more]
ephx34.030e-2958.89epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-59... [more]
crat4.861e-4824.96carnitine O-acetyltransferase b [Source:Xenbase;Ac... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ercc20.000e+059.74excision repair cross-complementing rodent repair ... [more]
Ercc20.000e+057.74excision repair cross-complementing rodent repair ... [more]
Ercc23.188e-3062.29excision repair cross-complementing rodent repair ... [more]
Ercc20.000e+061.30excision repair cross-complementing rodent repair ... [more]
Rtel14.732e-5524.08regulator of telomere elongation helicase 1 [Sourc... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O08811|ERCC2_MOUSE0.000e+059.74General transcription and DNA repair factor IIH he... [more]
sp|A6QLJ0|ERCC2_BOVIN0.000e+059.74General transcription and DNA repair factor IIH he... [more]
sp|P18074|ERCC2_HUMAN0.000e+059.60General transcription and DNA repair factor IIH he... [more]
sp|Q60452|ERCC2_CRIGR0.000e+059.31General transcription and DNA repair factor IIH he... [more]
sp|P26659|RAD15_SCHPO0.000e+050.50General transcription and DNA repair factor IIH he... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
T1IV490.000e+061.06Helicase ATP-binding domain-containing protein OS=... [more]
A0A4S2LEP90.000e+060.20Helicase ATP-binding domain-containing protein OS=... [more]
A0A3Q0KUN30.000e+060.06DNA repair helicase rad3/xp-d, putative OS=Schisto... [more]
A7RNX60.000e+059.86Predicted protein OS=Nematostella vectensis OX=453... [more]
A0A0X3PDU90.000e+059.77TFIIH basal transcription factor complex helicase ... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ercc20.000e+058.16ERCC excision repair 2, TFIIH core complex helicas... [more]
ercc20.000e+058.42ERCC excision repair 2, TFIIH core complex helicas... [more]
ercc28.719e-2660.19ERCC excision repair 2, TFIIH core complex helicas... [more]
rtel13.477e-5625.58regulator of telomere elongation helicase 1 [Sourc... [more]
rtel13.530e-5625.58regulator of telomere elongation helicase 1 [Sourc... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ercc20.000e+052.93excision repair cross-complementation group 2 [Sou... [more]
ENSPMAT00000009331.11.018e-2729.36pep scaffold:Pmarinus_7.0:GL478127:7852:42501:1 ge... [more]
RTEL1-TNFRSF6B6.920e-2125.30RTEL1-TNFRSF6B readthrough (NMD candidate) [Source... [more]
RTEL1-TNFRSF6B1.553e-1925.83RTEL1-TNFRSF6B readthrough (NMD candidate) [Source... [more]
RTEL1-TNFRSF6B2.880e-1826.77RTEL1-TNFRSF6B readthrough (NMD candidate) [Source... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
RAD30.000e+047.315' to 3' DNA helicase; involved in nucleotide exci... [more]
CHL13.834e-4024.63Probable DNA helicase; involved in sister-chromati... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO467540.000e+059.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO393883.013e-3125.27Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ercc20.000e+058.44ERCC excision repair 2, TFIIH core complex helicas... [more]
ercc20.000e+058.51ERCC excision repair 2, TFIIH core complex helicas... [more]
ddx119.263e-5125.75DEAD/H-box helicase 11 [Source:NCBI gene;Acc:10116... [more]
brip13.053e-3228.48BRCA1 interacting protein C-terminal helicase 1 [S... [more]
brip13.232e-3228.48BRCA1 interacting protein C-terminal helicase 1 [S... [more]
back to top
BLAST of TFIIH basal transcription factor complex helicase XPD subunit vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000046165.10.000e+099.86SMESG000046165.1[more]
SMESG000046165.10.000e+0100.00SMESG000046165.1[more]
SMESG000018012.12.124e-5826.29SMESG000018012.1[more]
SMESG000064419.14.174e-5826.77SMESG000064419.1[more]
SMESG000064419.14.716e-5826.77SMESG000064419.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30028922 ID=SMED30028922|Name=TFIIH basal transcription factor complex helicase XPD subunit|organism=Schmidtea mediterranea sexual|type=transcript|length=2363bp
CCATCTTCAGATTTTTGTTGTTTAAATAATATTTTTTAAAATGAAGATTG
ATATCGACGGTCTGGAAGTATTTTTCCCGTATGATTATGTTTATAAAGAA
CAATATGAATATATGCAAGCATTGAAACAATCTGTCGACAGCTCATTGTA
TGCTTGAGATGCCATCTGGGACTGGGAAAACTATATCTTTATTATCATTA
TTAGTTTCATATATGAAACAATATCCTTCAAAATTAACCAAAATAATATA
TTGTTCCAGAACTGTGACAGAATTAGAAAAAGTAATTCAAGAATTACAGA
ACTTAATAAATTTGATGGAAATCGAAACTCACCAAAAATGTAATATTTTG
GGAGTGGCGTTAAGTGCTCGAAAAAATATGTGTATAAATTCTGATGTCTT
AAATTGTTCTTCCGGCAACATTGATGTCACATGTCGTGGGCTAACTGCAA
GTTTTGTGAGAGCTAGACATCAGGTTGACAGTACAGTTCCAGTGTGTAAA
TATTTCGAAGCATTCGATATTCGAGACAGAGATGAATCTCTTCCTTACGG
AATTTATCATTTAGAAGATTTAAAAGAATACGGCAGACAGCATGGCATTT
GTCCTTATTTTTTAACTAGAAACACGATATCACATGCTAATATCATTGTT
TACAGCTATTATTATTTACTCGATCCTAAAATTGCTAACCTCGTGTCCAA
GGATTTGCCTAAATCATCTGTAGTCATTTTTGACGAAGCGCATAATATCG
ATAATGTTTGCATTGAATCTATGAGTTGTACTATCAACAGGAACACCATT
AAATCAGCAAGTAACAGTTTAGGGTCATTAAAAGATGTTGTTAGAAGGAC
AAAAGAATTGGACAAGGAGAAACTAACAAATGAATACAATAAATTGGTTG
CAAATCTCAGAATAGCCAATGAAGCAAGAATGGAAGATTTAATTCTGGCT
AATCCAACATTGCCCGAGGACGTTTTAATTGAAGCGATTCCGGGAAACAT
TAGACAAGCCGATCATTTCTTAAATTTCTTTCAGCGATTTATTGCATTTG
TCGATTGCAGACTGCGCACAAGTGCAGTTCGCTATGAAACGCCAGCAGTT
TTTCTCAGAGACTGTGCGGCTAATGCTGGAATTTTGCGGCATCCATTGCG
ATTTTGTTCCGAGCGGATTCAATCTATTCTTCACAATTTGGAAATCTCTG
ATTTGACAATTTATCAAAGCTTATTGCAAGTTGCCAATTTTGCGACGATG
GTGTCGACTTATATTGACGGATTCAGCATTATCATTGAGCCATTCGATGA
GAGGACGCCGACAATTCCATTTCCCGTGCTGCATTTCAATTGCATGGATT
CTGCATTGGCCATTAAGCCGATTTTGGCTAGATTTAATACAGTCATCATT
ACTTCTGGGACATTATCGCCCATGGATATTTATCAAAAAATCCTCGATTG
TCATCCGGGAATCAGCAAGTCTTTGACCATGAGTTTAGCTAGAAACTGCA
TCAGGCCTCTGATTGTCACAAAGGGAAAAGATCAAATGGCTATAACAACT
AAATTCGAGAATAGAGAGGACACATCAATCATTCGAAATTATGGCCATTT
GCTACTGGAGCTGTCAATGGTGGTGCCGGATGGAGTTGTAGCTTTCTTTC
CTAGTTACACATATCTAGAAACCACCTTTACTACTTGGTATTCTTCGGGA
ATCGTCAGCGATATCCAGAAACATAAACTGATTTTCATAGAAACTCAAGA
TGCCGATGAGACAAATGTTGCTCTTTACAATTATAAAAAGGCTTGTGAAA
ATGGAAGAGGCGCTATTTTGTTATCTGTTGCGAGAGGAAAAATATCTGAA
GGAATTGATTTCGATCATCATTTAGGGAGATGCGTTATCATGTTCGGAAT
CCCATTCTTTTTCACTCAAAGTCGAATCATTAAGGCTCGCTTGACATATC
TGAAAGATCATTTCCGAATATCTGAAAACGATTTCATAAATTTTGATGCG
ATGAGACACGCCGCCCAATGCCTAGGACGAGCTATTAGAGGCAAAACTGA
TTACGGCCTCATGATTTTAGCTGATAAGCGTTACAACCGGCCCGACAAAC
GTGGAAAACTACCGCAATGGATTTCAACCCATCTTGATGATATGTATTTA
AACCTCAGCACGGAGGAGGCGGTTCAAATGGCCAAACGATTTCTTCGGGA
AATGGGGCAGGAATTCAACTATGAGAAGCAATTGAAATTGGCCATATCAT
ACAAAAAGGTCGATTAATATTTTGTATAATAAAAGAGTATTGAGTTTTGT
TATTGATTTTGATGTGAGCCCGTCGGATATAGTTTCAAACCCCTCTCCAA
AAAAATATCAAGC
back to top

protein sequence of SMED30028922-orf-1

>SMED30028922-orf-1 ID=SMED30028922-orf-1|Name=SMED30028922-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=706bp
MLEMPSGTGKTISLLSLLVSYMKQYPSKLTKIIYCSRTVTELEKVIQELQ
NLINLMEIETHQKCNILGVALSARKNMCINSDVLNCSSGNIDVTCRGLTA
SFVRARHQVDSTVPVCKYFEAFDIRDRDESLPYGIYHLEDLKEYGRQHGI
CPYFLTRNTISHANIIVYSYYYLLDPKIANLVSKDLPKSSVVIFDEAHNI
DNVCIESMSCTINRNTIKSASNSLGSLKDVVRRTKELDKEKLTNEYNKLV
ANLRIANEARMEDLILANPTLPEDVLIEAIPGNIRQADHFLNFFQRFIAF
VDCRLRTSAVRYETPAVFLRDCAANAGILRHPLRFCSERIQSILHNLEIS
DLTIYQSLLQVANFATMVSTYIDGFSIIIEPFDERTPTIPFPVLHFNCMD
SALAIKPILARFNTVIITSGTLSPMDIYQKILDCHPGISKSLTMSLARNC
IRPLIVTKGKDQMAITTKFENREDTSIIRNYGHLLLELSMVVPDGVVAFF
PSYTYLETTFTTWYSSGIVSDIQKHKLIFIETQDADETNVALYNYKKACE
NGRGAILLSVARGKISEGIDFDHHLGRCVIMFGIPFFFTQSRIIKARLTY
LKDHFRISENDFINFDAMRHAAQCLGRAIRGKTDYGLMILADKRYNRPDK
RGKLPQWISTHLDDMYLNLSTEEAVQMAKRFLREMGQEFNYEKQLKLAIS
YKKVD*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003678DNA helicase activity
GO:0016818hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0004003ATP-dependent DNA helicase activity
GO:0003677DNA binding
GO:0005524ATP binding
GO:0003676nucleic acid binding
GO:0008026ATP-dependent helicase activity
GO:0000166nucleotide binding
GO:0004386helicase activity
GO:0004672protein kinase activity
GO:0008022protein C-terminus binding
GO:0008094DNA-dependent ATPase activity
GO:0008353RNA polymerase II carboxy-terminal domain kinase activity
GO:0016787hydrolase activity
GO:00431395'-3' DNA helicase activity
GO:0046872metal ion binding
GO:0047485protein N-terminus binding
GO:0051536iron-sulfur cluster binding
GO:00515394 iron, 4 sulfur cluster binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR013020Rad3/Chl1-like
IPR004217Tim10-like
IPR001945RAD3/XPD
IPR006554Helicase-like_DEXD_c2
IPR006555ATP-dep_Helicase_C
IPR027417P-loop_NTPase
IPR010643HBB
IPR010614DEAD_2
IPR002464DNA/RNA_helicase_DEAH_CS
IPR014013Helic_SF1/SF2_ATP-bd_DinG/Rad3
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0000439core TFIIH complex
GO:0005654nucleoplasm
GO:0005669transcription factor TFIID complex
GO:0005675holo TFIIH complex
GO:0005737cytoplasm
GO:0005819spindle
GO:0005829cytosol
GO:0005856cytoskeleton
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0071817MMXD complex
Vocabulary: biological process
TermDefinition
GO:0006289nucleotide-excision repair
GO:0006139nucleobase-containing compound metabolic process
GO:0001666response to hypoxia
GO:0001701in utero embryonic development
GO:0006281DNA repair
GO:0006283transcription-coupled nucleotide-excision repair
GO:0006351transcription, DNA-templated
GO:0006355regulation of transcription, DNA-templated
GO:0006366transcription from RNA polymerase II promoter
GO:0006468protein phosphorylation
GO:0006915apoptotic process
GO:0006974cellular response to DNA damage stimulus
GO:0006979response to oxidative stress
GO:0007059chromosome segregation
GO:0007568aging
GO:0008283cell proliferation
GO:0009411response to UV
GO:0009650UV protection
GO:0009791post-embryonic development
GO:0021510spinal cord development
GO:0022405hair cycle process
GO:0030198extracellular matrix organization
GO:0030282bone mineralization
GO:0032289central nervous system myelin formation
GO:0032508DNA duplex unwinding
GO:0033683nucleotide-excision repair, DNA incision
GO:0035264multicellular organism growth
GO:0035315hair cell differentiation
GO:0040016embryonic cleavage
GO:0043249erythrocyte maturation
GO:0043388positive regulation of DNA binding
GO:0043588skin development
GO:0045893positive regulation of transcription, DNA-templated
GO:0045944positive regulation of transcription from RNA polymerase II promoter
GO:0048568embryonic organ development
GO:0048820hair follicle maturation
GO:0060218hematopoietic stem cell differentiation
GO:1901990regulation of mitotic cell cycle phase transition
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 39..62
NoneNo IPR availableCOILSCoilCoilcoord: 232..259
NoneNo IPR availableGENE3DG3DSA:3.40.50.300coord: 458..657
e-value: 1.0E-43
score: 151.0
NoneNo IPR availableGENE3DG3DSA:3.40.50.300coord: 1..258
e-value: 3.8E-48
score: 165.8
NoneNo IPR availablePANTHERPTHR11472DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBERcoord: 1..697
NoneNo IPR availableCDDcd17969DEAHc_XPDcoord: 412..441
e-value: 4.46679E-7
score: 48.196
NoneNo IPR availableCDDcd17969DEAHc_XPDcoord: 1..207
e-value: 6.10136E-44
score: 153.355
NoneNo IPR availableCDDcd18788SF2_C_XPDcoord: 449..645
e-value: 3.13387E-69
score: 221.324
IPR001945RAD3/XPD familyPRINTSPR00852XRODRMPGMNTDcoord: 364..382
score: 72.93
coord: 333..355
score: 52.17
coord: 234..253
score: 45.71
coord: 668..688
score: 56.46
coord: 294..315
score: 32.47
coord: 269..287
score: 66.92
coord: 597..619
score: 63.98
coord: 453..470
score: 57.94
IPR001945RAD3/XPD familyPANTHERPTHR11472:SF1GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPDcoord: 1..697
IPR006555ATP-dependent helicase, C-terminalSMARTSM00491Cxpdneu3coord: 503..647
e-value: 4.9E-62
score: 222.1
IPR006555ATP-dependent helicase, C-terminalPFAMPF13307Helicase_C_2coord: 485..659
e-value: 2.2E-45
score: 154.9
IPR006554Helicase-like, DEXD box c2 typeSMARTSM00488deadxpdcoord: 2..241
e-value: 5.4E-63
score: 225.3
IPR013020ATP-dependent helicase Rad3/Chl1-likeTIGRFAMTIGR00604TIGR00604coord: 2..669
e-value: 2.8E-224
score: 744.7
IPR010643Helical and beta-bridge domainPFAMPF06777HBBcoord: 231..373
e-value: 3.4E-26
score: 92.1
IPR010614DEAD2PFAMPF06733DEAD_2coord: 34..216
e-value: 1.5E-47
score: 161.4
IPR002464DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved sitePROSITEPS00690DEAH_ATP_HELICASEcoord: 190..199
IPR014013Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-typePROSITEPS51193HELICASE_ATP_BIND_2coord: 1..257
score: 24.411
IPR027417P-loop containing nucleoside triphosphate hydrolaseSUPERFAMILYSSF52540P-loop containing nucleoside triphosphate hydrolasescoord: 2..640