Sld5 domain-containing protein

Overview
NameSld5 domain-containing protein
Smed IDSMED30028865
Length (bp)647
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Sld5 domain-containing protein (SMED30028865) t-SNE clustered cells

Violin plots show distribution of expression levels for Sld5 domain-containing protein (SMED30028865) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Sld5 domain-containing protein (SMED30028865) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Sld5 domain-containing protein (SMED30028865) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30028865

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30028865h1SMcG0010498 SmedASXL_009081SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30028865h1SMcG0010498 dd_Smed_v4_9624_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parapharyngeal regionSMED30028865h1SMcG0010498 dd_Smed_v6_9624_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
zeta neoblastSMED30028865h1SMcG0010498 dd_Smed_v4_9624_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Human
Match: GINS3 (GINS complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:25851])

HSP 1 Score: 82.4185 bits (202), Expect = 8.608e-19
Identity = 55/192 (28.65%), Postives = 97/192 (50.52%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCL---NSAKTSTADLI-ETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVG-ATQ--AANIKSNSNK 610
            N+ ++DDIL ++ K P      MP +G      SA   T + + +  K ELPLWL +GL    + +++  LP  Y E +R +++ADP   ++    P+FY      L  +  PE  DI+ ++ +    R   I+ ++  A  +  +   +++D +E+G+FQ   +   + Q W  G A+Q  A+N+  N  K
Sbjct:   18 NFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAVPQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFGSQLLHFDS-PENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQTGQKGLNDFQCWEKGQASQITASNLVQNYKK 208
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Human
Match: GINS3 (GINS complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:25851])

HSP 1 Score: 69.707 bits (169), Expect = 7.988e-14
Identity = 57/231 (24.68%), Postives = 100/231 (43.29%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGC--------------------------------LNSAKTSTAD-----------LIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVG-ATQ--AANIKSNSNK 610
            N+ ++DDIL ++ K P      MP +G                                 L +A TS A            +++  K ELPLWL +GL    + +++  LP  Y E +R +++ADP   ++    P+FY      L  +  PE  DI+ ++ +    R   I+ ++  A  +  +   +++D +E+G+FQ   +   + Q W  G A+Q  A+N+  N  K
Sbjct:   18 NFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAVPQGFALLPRLECSGVIWLTAALTSQAPEILPPQPPMWLVLQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFGSQLLHFDS-PENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQTGQKGLNDFQCWEKGQASQITASNLVQNYKK 247
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Fly
Match: Psf3 (gene:FBgn0030196 transcript:FBtr0071465)

HSP 1 Score: 56.225 bits (134), Expect = 1.476e-9
Identity = 38/169 (22.49%), Postives = 76/169 (44.97%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKNV-VTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWL 565
            NY++I+DI  T  K  C +N  +  +G L+S   S  DL       LPLW ++ L   N   T  +P+ Y   ++ +  A+  +  +    PYFY+   +   +  +     I   + + L++R+  ++       +    K + ++D++E  + +    T  +  +WL
Sbjct:    9 NYYSIEDIFVTQEKVECRVNTKLQRMGFLDSGAESD-DLEPGRTVNLPLWYIKELKVNNAYFTVAVPDIYRNVHKAVCEAETTHIELGRLHPYFYEFGRY---LTPYDRNHVIGRIIFETLRQRVRHLLD--ISKSDGQAAKAEHRLDNIEAKLHEAGVRTNSQYIEWL 171
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Fly
Match: Psf3 (gene:FBgn0030196 transcript:FBtr0346350)

HSP 1 Score: 56.225 bits (134), Expect = 1.476e-9
Identity = 38/169 (22.49%), Postives = 76/169 (44.97%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKNV-VTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWL 565
            NY++I+DI  T  K  C +N  +  +G L+S   S  DL       LPLW ++ L   N   T  +P+ Y   ++ +  A+  +  +    PYFY+   +   +  +     I   + + L++R+  ++       +    K + ++D++E  + +    T  +  +WL
Sbjct:    9 NYYSIEDIFVTQEKVECRVNTKLQRMGFLDSGAESD-DLEPGRTVNLPLWYIKELKVNNAYFTVAVPDIYRNVHKAVCEAETTHIELGRLHPYFYEFGRY---LTPYDRNHVIGRIIFETLRQRVRHLLD--ISKSDGQAAKAEHRLDNIEAKLHEAGVRTNSQYIEWL 171
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Fly
Match: Psf3 (gene:FBgn0030196 transcript:FBtr0333306)

HSP 1 Score: 56.225 bits (134), Expect = 1.476e-9
Identity = 38/169 (22.49%), Postives = 76/169 (44.97%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKNV-VTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWL 565
            NY++I+DI  T  K  C +N  +  +G L+S   S  DL       LPLW ++ L   N   T  +P+ Y   ++ +  A+  +  +    PYFY+   +   +  +     I   + + L++R+  ++       +    K + ++D++E  + +    T  +  +WL
Sbjct:    9 NYYSIEDIFVTQEKVECRVNTKLQRMGFLDSGAESD-DLEPGRTVNLPLWYIKELKVNNAYFTVAVPDIYRNVHKAVCEAETTHIELGRLHPYFYEFGRY---LTPYDRNHVIGRIIFETLRQRVRHLLD--ISKSDGQAAKAEHRLDNIEAKLHEAGVRTNSQYIEWL 171
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Zebrafish
Match: gins3 (GINS complex subunit 3 [Source:ZFIN;Acc:ZDB-GENE-040721-1])

HSP 1 Score: 83.1889 bits (204), Expect = 2.831e-19
Identity = 48/160 (30.00%), Postives = 82/160 (51.25%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIV---SNAFFADEKSFTKEKSKMDSLEQGIFQ 526
            N+F++DDIL ++ + PC   +  P +G L  +  S  D+ E  K E+PLWL +GL    + V++  LP  Y E +R ++ ADP   ++    PY+Y +    L  E  PE  +IA  + +    R    +    NA+  D  +  +   ++D LE+ +F+
Sbjct:   18 NFFSLDDILLSHERLPCRTESAFPRLGFLEKSSDSR-DIPEGSKMEMPLWLAKGLYERKRRVLSVELPKVYREGWRTVFGADPTVVDLYKMGPYYYGLGSQMLHFES-PENPEIANTILQTFIGRFRRTMDSSQNAYNEDTSALVE---RLDYLERSLFK 172
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Zebrafish
Match: gins3 (GINS complex subunit 3 [Source:ZFIN;Acc:ZDB-GENE-040721-1])

HSP 1 Score: 49.6766 bits (117), Expect = 6.067e-8
Identity = 26/72 (36.11%), Postives = 39/72 (54.17%), Query Frame = 2 
Query:  191 KAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIA 400
            K E+PLWL +GL    + V++  LP  Y E +R ++ ADP   ++    PY+Y +    L  E  PE  +IA
Sbjct:    4 KMEMPLWLAKGLYERKRRVLSVELPKVYREGWRTVFGADPTVVDLYKMGPYYYGLGSQMLHFES-PENPEIA 74
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Xenopus
Match: gins3 (coiled-coil domain containing 113 [Source:NCBI gene;Acc:548359])

HSP 1 Score: 79.337 bits (194), Expect = 1.040e-17
Identity = 50/183 (27.32%), Postives = 90/183 (49.18%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNS 604
            N+ +I+D+L +  K PC + +  P +G L     S + + E  K ELPLWL +GL    + V++  LP  Y E +R +++AD    ++    P++Y      L  +  PE  +IA  + +    R   I+ ++  A  +  +   +++D LE+ +F+         Q W  G  +AA I ++S
Sbjct:   17 NFLSIEDLLMSQEKLPCRVESGFPRLGFLEKGGDSDS-IPEGSKMELPLWLAKGLYDNKRRVLSVELPKIYREGWRTVFSADANVVDLHKMGPHYYGFGSQLLNFDS-PENPEIAKTILQTFVGRFRRIMDSSQNAYNEDTSGLVARLDELERSLFKAGQRGLNAFQSWERG--KAAQITASS 195
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Xenopus
Match: gins3 (coiled-coil domain containing 113 [Source:NCBI gene;Acc:548359])

HSP 1 Score: 54.6842 bits (130), Expect = 2.782e-8
Identity = 41/149 (27.52%), Postives = 70/149 (46.98%), Query Frame = 2 
Query:  173 DLIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIV---SNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNS 604
            ++ E  K ELPLWL +GL    + V++  LP  Y E +R +++AD    ++    P++Y      L  +  PE  +IA  + +    R   I+    NA+  D        +++D LE+ +F+         Q W  G  +AA I ++S
Sbjct:  366 EIAEGSKMELPLWLAKGLYDNKRRVLSVELPKIYREGWRTVFSADANVVDLHKMGPHYYGFGSQLLNFDS-PENPEIAKTILQTFVGRFRRIMDSSQNAYNEDTSGLV---ARLDELERSLFKAGQRGLNAFQSWERG--KAAQITASS 508
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Mouse
Match: Gins3 (GINS complex subunit 3 (Psf3 homolog) [Source:MGI Symbol;Acc:MGI:1926083])

HSP 1 Score: 82.0333 bits (201), Expect = 9.638e-19
Identity = 55/191 (28.80%), Postives = 94/191 (49.21%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGC--LNSAKTSTAD--LIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKS----KMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNS 604
            N+ ++DDIL +  K P  +   MP +G   L     S  D  L +  K ELPLWL +GL    + +++  LP  Y E +R +++AD    ++    P+FY      L  +  PE  DI+ ++ K    R   I+ ++    + S+ ++ S    ++D  E+G+FQ    +  + Q W  G  QA+ I ++S
Sbjct:   18 NFLSLDDILMSQEKLPVRVETPMPRLGAFFLERGAGSEPDHPLPQGTKLELPLWLAKGLFDHKRRILSVELPKMYQEGWRTVFSADANVVDLHKMGPHFYGFGSQLLHFDS-PENADISQSLLKTFIGRFRRIMDSS----QNSYNEDTSALVARLDETERGLFQIGQRSLNDFQSWEKG--QASQITASS 201
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Mouse
Match: Gins3 (GINS complex subunit 3 (Psf3 homolog) [Source:MGI Symbol;Acc:MGI:1926083])

HSP 1 Score: 69.3218 bits (168), Expect = 1.336e-14
Identity = 39/125 (31.20%), Postives = 63/125 (50.40%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGC--LNSAKTSTAD--LIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKL 418
            N+ ++DDIL +  K P  +   MP +G   L     S  D  L +  K ELPLWL +GL    + +++  LP  Y E +R +++AD    ++    P+FY      L  +  PE  DI+ ++ K+
Sbjct:   18 NFLSLDDILMSQEKLPVRVETPMPRLGAFFLERGAGSEPDHPLPQGTKLELPLWLAKGLFDHKRRILSVELPKMYQEGWRTVFSADANVVDLHKMGPHFYGFGSQLLHFDS-PENADISQSLLKV 141
[Close]
BLAST of Sld5 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9BRX5|PSF3_HUMAN (DNA replication complex GINS protein PSF3 OS=Homo sapiens OX=9606 GN=GINS3 PE=1 SV=1)

HSP 1 Score: 82.4185 bits (202), Expect = 4.134e-18
Identity = 55/192 (28.65%), Postives = 97/192 (50.52%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCL---NSAKTSTADLI-ETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVG-ATQ--AANIKSNSNK 610
            N+ ++DDIL ++ K P      MP +G      SA   T + + +  K ELPLWL +GL    + +++  LP  Y E +R +++ADP   ++    P+FY      L  +  PE  DI+ ++ +    R   I+ ++  A  +  +   +++D +E+G+FQ   +   + Q W  G A+Q  A+N+  N  K
Sbjct:   18 NFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAVPQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFGSQLLHFDS-PENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQTGQKGLNDFQCWEKGQASQITASNLVQNYKK 208
[Close]
BLAST of Sld5 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5RDV0|PSF3_PONAB (DNA replication complex GINS protein PSF3 OS=Pongo abelii OX=9601 GN=GINS3 PE=2 SV=1)

HSP 1 Score: 82.0333 bits (201), Expect = 6.013e-18
Identity = 46/161 (28.57%), Postives = 83/161 (51.55%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCL---NSAKTSTADLI-ETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQ 526
            N+ ++DDIL ++ K P      MP +G      SA   T + + +  K ELPLWL +GL    + +++  LP  Y E +R +++ADP   ++    P+FY      L  +  PE  DI+ ++ +    R   I+ ++  A  +  +   +++D +E+G+FQ
Sbjct:   18 NFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAVPQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFGSQLLHFDS-PENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQ 177
[Close]
BLAST of Sld5 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9CY94|PSF3_MOUSE (DNA replication complex GINS protein PSF3 OS=Mus musculus OX=10090 GN=Gins3 PE=2 SV=1)

HSP 1 Score: 82.0333 bits (201), Expect = 6.742e-18
Identity = 55/191 (28.80%), Postives = 94/191 (49.21%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGC--LNSAKTSTAD--LIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKS----KMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNS 604
            N+ ++DDIL +  K P  +   MP +G   L     S  D  L +  K ELPLWL +GL    + +++  LP  Y E +R +++AD    ++    P+FY      L  +  PE  DI+ ++ K    R   I+ ++    + S+ ++ S    ++D  E+G+FQ    +  + Q W  G  QA+ I ++S
Sbjct:   18 NFLSLDDILMSQEKLPVRVETPMPRLGAFFLERGAGSEPDHPLPQGTKLELPLWLAKGLFDHKRRILSVELPKMYQEGWRTVFSADANVVDLHKMGPHFYGFGSQLLHFDS-PENADISQSLLKTFIGRFRRIMDSS----QNSYNEDTSALVARLDETERGLFQIGQRSLNDFQSWEKG--QASQITASS 201
[Close]
BLAST of Sld5 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q08E12|PSF3_BOVIN (DNA replication complex GINS protein PSF3 OS=Bos taurus OX=9913 GN=GINS3 PE=2 SV=1)

HSP 1 Score: 76.2554 bits (186), Expect = 8.088e-16
Identity = 45/162 (27.78%), Postives = 81/162 (50.00%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCL-----NSAKTSTADLIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQ 526
            N+ ++DDIL ++ K        MP +G         A+T  A + E  K ELPLWL +GL    + +++  LP  Y E +R +++AD    ++    P+FY      L  +  PE  DI+ ++ +    R   I+ ++  A  +  +   +++D +E+G+FQ
Sbjct:   18 NFLSLDDILMSHEKLSVRTEIPMPRLGAFFLDRSGGAETDNA-IPEGTKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADANVVDLHKMGPHFYGFGSQLLHFDS-PENADISHSLLQTFVGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQ 177
[Close]
BLAST of Sld5 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q54EH6|PSF3_DICDI (Probable DNA replication complex GINS protein PSF3 OS=Dictyostelium discoideum OX=44689 GN=gins3 PE=3 SV=1)

HSP 1 Score: 58.5362 bits (140), Expect = 4.303e-9
Identity = 42/184 (22.83%), Postives = 88/184 (47.83%), Query Frame = 2 
Query:   65 YFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNSNKSL 616
            YF+I+DILA   K  C    +  ++G L    +   D+ +  K +LP W+   L   N V+ ++P  Y + Y+    ADP   ++R + PY+ +I    +++  F   + + + + ++ +ER  +I S +    E   +K    +   E+ +F   +++  +   W+  + +   ++ N+N  L
Sbjct:    3 YFDINDILAEEQKITCNFFYDAYNLGQLEEG-SRDPDMKKGSKVDLPYWMALALAKSNFVSVIMPPEYQDEYKNKLIADPNVISMRLF-PYYDKIG---VQLSDFFGDRKLKLLLFRVFRERFLNIYSQSINLKETDISKILGNLTYQEREVFSNGYKSSNDYDKWM--SRKGEKVEKNTNNLL 179
[Close]
BLAST of Sld5 domain-containing protein vs. TrEMBL
Match: A0A0P4W830 (Sld5 domain-containing protein OS=Scylla olivacea OX=85551 PE=4 SV=1)

HSP 1 Score: 99.3673 bits (246), Expect = 3.606e-22
Identity = 58/188 (30.85%), Postives = 97/188 (51.60%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKN-VVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNSNKSLKR 622
            NY++++DILATN K PC     +  +G L+S+  S  DL +  K ELPLWL   L P+  +VT  LP  +NE YR+I  AD    +++  +PYFY+   H L +    E   +   +++ L++R+  ++ ++    E      K++ D LE+ +F        + Q WL          +++ +S KR
Sbjct:   15 NYYSLEDILATNEKLPCKFEKTVVGMGYLDSSGRSK-DLDKGTKLELPLWLAAALGPRRKLVTCHLPRAFNERYREILRADATIVDLQGLAPYFYEFGRHLLPL-VGAEGVTLGQLLTETLKQRLRRVMDSSLHCLEDDAAVHKARFDHLERTLFHTGRRMYQDHQLWLARRCHIITSIASTEQSGKR 200
[Close]
BLAST of Sld5 domain-containing protein vs. TrEMBL
Match: A0A4Y7NJB7 (EOG090X0G8U OS=Moina brachiata OX=675436 GN=EOG090X0G8U PE=2 SV=1)

HSP 1 Score: 95.9005 bits (237), Expect = 8.325e-21
Identity = 54/194 (27.84%), Postives = 92/194 (47.42%), Query Frame = 2 
Query:   47 LYHAGNYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNSNKSLKRHF 628
            L ++ NY++++DIL  + +  C     +P +G L+ A +   DL +  K ELP W+V  L  K VV+  +P FY  NYR+I  AD    N+  W PYFY +  H   ++   E+ D+   +   +Q R+  I+  +  +         + MD LE+ +F     +    ++W+   +   N  +      KR F
Sbjct:    5 LSYSPNYYSLEDILLQDVRVSCTFEVGVPKLGMLD-ASSDEKDLKKGSKVELPFWMVPTLYEKKVVSFEIPRFYRVNYRQILKADSQVVNLHKWGPYFYDLGLHIANLD-LKESPDMKECLVDTIQNRLRQIMDMSQHSTHHETVHLIAHMDELERKLFAVGQSSFRHYKEWIRRESSKINTAALVASHRKRKF 196
[Close]
BLAST of Sld5 domain-containing protein vs. TrEMBL
Match: A0A0B7BGQ5 (Sld5 domain-containing protein (Fragment) OS=Arion vulgaris OX=1028688 GN=ORF186234 PE=4 SV=1)

HSP 1 Score: 95.5153 bits (236), Expect = 1.139e-20
Identity = 57/171 (33.33%), Postives = 84/171 (49.12%), Query Frame = 2 
Query:   56 AGNYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGL--VPKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDW 562
            A NYF++DDILA+    PC  N  + S+G L+ + T T D+    K +LP WL + L    + +V+   P  Y E YR I+ ADP   ++    PYFY      L M+  P+T DIA  + K  Q R   I+  +  A       + +K+D  E+ +F    +   E Q W
Sbjct:   15 ANNYFSLDDILASQEAVPCTFNVKVASMGYLDQSTTDT-DINVGTKLDLPFWLAKYLHRGTRGIVSVETPKNYKEGYRHIFTADPNVVDLHRLGPYFYLFGEKILSMQ-LPDTDDIANILLKTFQGRFRDIMDGSQNALHHDLATQITKLDEQERKLFAAGQQGLHEFQKW 183
[Close]
BLAST of Sld5 domain-containing protein vs. TrEMBL
Match: R7TT89 (Sld5 domain-containing protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_21464 PE=4 SV=1)

HSP 1 Score: 95.5153 bits (236), Expect = 1.453e-20
Identity = 61/198 (30.81%), Postives = 101/198 (51.01%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVP--KNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIF---QQLFETRLETQDWLVGATQAANIKSNSNKSLKRHFPFDE 640
            +YF+IDDILAT  + P +      ++G L+S+ + T ++      ELP W+ + L    K++V+  LPN Y E+ R+I  A+    N+  W PYFY+     L  E+ PE+ DIA ++ + LQ R   I+ +A  A  +       K+D LE  IF   Q+  E++L+ +   +     + +  N  K  + H   D+
Sbjct:   18 SYFDIDDILATQERVPVVFQVPALNLGYLDSS-SETNNIEAGAAMELPFWMAKALSTRGKHMVSVDLPNSYKESQREILGAEAGVVNLHKWGPYFYKFGMCLLCFEH-PESTDIAKSLLQTLQNRFRGIMDSAQNASYEEIASVTKKLDVLEMSIFRVGQKSIESQLQWEKRQIEKLTVSKVIVNHRKRKRIHIENDQ 213
[Close]
BLAST of Sld5 domain-containing protein vs. TrEMBL
Match: C1BMP0 (DNA replication complex GINS protein PSF3 OS=Caligus rogercresseyi OX=217165 GN=PSF3 PE=2 SV=1)

HSP 1 Score: 92.4337 bits (228), Expect = 1.236e-19
Identity = 52/189 (27.51%), Postives = 102/189 (53.97%), Query Frame = 2 
Query:   56 AGNYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYL-RMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWL---VGATQAANIKSNSNK 610
            + +Y ++ DILAT+ + P   ++++ S+G L+ + +   DL E  K E+PLW+V  L+ ++ + P  P  Y+  +R+I  ADP+  ++    PYFYQ   + L +    P+ + +   + ++L+ R   I+ ++  A+E     +K+K+D+LE+ +F    E++ +   W     G    A++ S   K
Sbjct:    2 SSSYLDLHDILATSYRIPVKTSSSLKSLGFLDPS-SGLEDLPENFKVEMPLWMVFPLL-RHGLGPDFPKSYSSGHREILEADPSVVDLHKAGPYFYQNGIYLLSKFGGHPDAERLGKILPEVLRRRFRMIMDSSQHAEEGDALTQKAKLDALERELFSAGQESKRQVSAWFKRKTGQIHTADMVSRHYK 188
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Cavefish
Match: gins3 (GINS complex subunit 3 [Source:NCBI gene;Acc:111195754])

HSP 1 Score: 77.0258 bits (188), Expect = 3.814e-17
Identity = 43/158 (27.22%), Postives = 77/158 (48.73%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQ 529
            N+ ++DDIL +  + PC  +   P +G L      +  + E  K E+PLWL +GL    + V++  LP  Y E +R ++ AD    ++    PY+Y +    L  +  PE  +IA  V +    R    + ++  A  +  +    ++D LE+ +F+Q
Sbjct:   15 NFLSLDDILLSQERLPCKTDTEFPGLGFLEK-NADSRHIPEGTKMEMPLWLAKGLYERKRRVISVELPKVYREGWRTVFGADANVVDLHKMGPYYYGLGSQMLHFDS-PENLEIAQTVLQTFIGRFRRTMDSSQNAYNEDTSMLVERLDCLERALFRQ 170
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Cavefish
Match: gins3 (GINS complex subunit 3 [Source:NCBI gene;Acc:111195754])

HSP 1 Score: 77.0258 bits (188), Expect = 4.332e-17
Identity = 43/158 (27.22%), Postives = 77/158 (48.73%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQ 529
            N+ ++DDIL +  + PC  +   P +G L      +  + E  K E+PLWL +GL    + V++  LP  Y E +R ++ AD    ++    PY+Y +    L  +  PE  +IA  V +    R    + ++  A  +  +    ++D LE+ +F+Q
Sbjct:   18 NFLSLDDILLSQERLPCKTDTEFPGLGFLEK-NADSRHIPEGTKMEMPLWLAKGLYERKRRVISVELPKVYREGWRTVFGADANVVDLHKMGPYYYGLGSQMLHFDS-PENLEIAQTVLQTFIGRFRRTMDSSQNAYNEDTSMLVERLDCLERALFRQ 173
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Yeast
Match: PSF3 (Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p); complex is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [Source:SGD;Acc:S000005506])

HSP 1 Score: 50.447 bits (119), Expect = 2.146e-8
Identity = 45/195 (23.08%), Postives = 86/195 (44.10%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLV---------EGLV---PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNA------FFADEKSFTKEKS---------KMDSLEQGIFQQLFETRLETQDWL 565
             Y++IDD+LA   + PC    ++P +G L +       + +  K  LPLWL          E LV   P   V  L P+ ++         DP   ++ + + +F+ +   ++ +  F E K++A  VS+LL +R   +  +A        AD        +         K++ +E+ I+++  E+  +T+ W+
Sbjct:    2 GYYDIDDVLADGTEFPCKFQYDIPGLGYLEN--NPGRPITKNTKLSLPLWLARILAIVGGDEALVDEEPVPFVELLPPDMFSTKVMNAIKTDPVALDLHSINSHFFSLAIKWIML--FSE-KELANVVSELLLQRAQELNHHASSLSIDLNADSTGKNSANTNIATSTFLLKLEEMEKEIYKKSHESYKDTKRWM 191
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Nematostella
Match: EDO34905 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMZ3])

HSP 1 Score: 85.5001 bits (210), Expect = 1.073e-20
Identity = 53/175 (30.29%), Postives = 90/175 (51.43%), Query Frame = 2 
Query:   56 AGNYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIET-MKAELPLWLVEGLVPKN--VVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVG 571
            + +YF++DD+LAT  + PC +   + ++G L+   +S  D + +  K ELPLWL   L  +   +V+  +P  Y E+YR+I  AD    ++    PYFY+I    +  EY  E   I  A+ +   +R   I+ ++  A  +  T   SK+D LE+ +F++  +   E   W  G
Sbjct:   15 SNDYFDLDDVLATQERIPCKLEVQIYNLGFLDP--SSEGDHLHSGSKLELPLWLARELCSRRRKIVSVEIPKGYKESYREILKADANVVDLHRLGPYFYEIGTKLMHFEY-DENPQIVKAIQETFIKRFRKIMDSSQNAPNEDSTSLTSKLDHLERQLFEKGKKGIKEFLQWEAG 186
[Close]
BLAST of Sld5 domain-containing protein vs. Ensembl Medaka
Match: gins3 (GINS complex subunit 3 [Source:NCBI gene;Acc:101159897])

HSP 1 Score: 81.6481 bits (200), Expect = 8.685e-19
Identity = 48/160 (30.00%), Postives = 82/160 (51.25%), Query Frame = 2 
Query:   62 NYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLV--PKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIV---SNAFFADEKSFTKEKSKMDSLEQGIFQ 526
            N+ ++DDIL ++ + P       P +G L+ + + + DL E  K ELPLWL +GL    + V++  LP  Y E +R ++ ADP   N+    PY+Y +    L  +  PE  DIA  + +    R   ++    NA+  D  +  +   ++D LE+ +F+
Sbjct:   18 NFLSLDDILLSHQRHPVRTECAFPRLGFLDRS-SDSEDLPEGTKMELPLWLSKGLYERKRRVLSVELPKVYKEGWRTVFTADPNVVNLHKMGPYYYGLGSQMLHFDS-PENPDIAQTLLQTFIGRFRRVMDSSQNAYNEDTSTLVE---RLDCLEKALFR 172
[Close]
BLAST of Sld5 domain-containing protein vs. Planmine SMEST
Match: SMESG000002897.1 (SMESG000002897.1)

HSP 1 Score: 430.639 bits (1106), Expect = 4.543e-156
Identity = 205/206 (99.51%), Postives = 205/206 (99.51%), Query Frame = 2 
Query:   23 MDYNDDFSLYHAGNYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKNVVTPLLPNFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNSNKSLKRHFPFDE 640
            MDYNDDFSLYHAGNYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKNVVTPLLP FYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNSNKSLKRHFPFDE
Sbjct:    1 MDYNDDFSLYHAGNYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTADLIETMKAELPLWLVEGLVPKNVVTPLLPTFYNENYRKIYAADPAYRNVRNWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEKSFTKEKSKMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNSNKSLKRHFPFDE 206
The following BLAST results are available for this feature:
BLAST of Sld5 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
GINS38.608e-1928.65GINS complex subunit 3 [Source:HGNC Symbol;Acc:HGN... [more]
GINS37.988e-1424.68GINS complex subunit 3 [Source:HGNC Symbol;Acc:HGN... [more]
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BLAST of Sld5 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sld5 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Psf31.476e-922.49gene:FBgn0030196 transcript:FBtr0071465[more]
Psf31.476e-922.49gene:FBgn0030196 transcript:FBtr0346350[more]
Psf31.476e-922.49gene:FBgn0030196 transcript:FBtr0333306[more]
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BLAST of Sld5 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
gins32.831e-1930.00GINS complex subunit 3 [Source:ZFIN;Acc:ZDB-GENE-0... [more]
gins36.067e-836.11GINS complex subunit 3 [Source:ZFIN;Acc:ZDB-GENE-0... [more]
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BLAST of Sld5 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
gins31.040e-1727.32coiled-coil domain containing 113 [Source:NCBI gen... [more]
gins32.782e-827.52coiled-coil domain containing 113 [Source:NCBI gen... [more]
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BLAST of Sld5 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Gins39.638e-1928.80GINS complex subunit 3 (Psf3 homolog) [Source:MGI ... [more]
Gins31.336e-1431.20GINS complex subunit 3 (Psf3 homolog) [Source:MGI ... [more]
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BLAST of Sld5 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9BRX5|PSF3_HUMAN4.134e-1828.65DNA replication complex GINS protein PSF3 OS=Homo ... [more]
sp|Q5RDV0|PSF3_PONAB6.013e-1828.57DNA replication complex GINS protein PSF3 OS=Pongo... [more]
sp|Q9CY94|PSF3_MOUSE6.742e-1828.80DNA replication complex GINS protein PSF3 OS=Mus m... [more]
sp|Q08E12|PSF3_BOVIN8.088e-1627.78DNA replication complex GINS protein PSF3 OS=Bos t... [more]
sp|Q54EH6|PSF3_DICDI4.303e-922.83Probable DNA replication complex GINS protein PSF3... [more]
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BLAST of Sld5 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0P4W8303.606e-2230.85Sld5 domain-containing protein OS=Scylla olivacea ... [more]
A0A4Y7NJB78.325e-2127.84EOG090X0G8U OS=Moina brachiata OX=675436 GN=EOG090... [more]
A0A0B7BGQ51.139e-2033.33Sld5 domain-containing protein (Fragment) OS=Arion... [more]
R7TT891.453e-2030.81Sld5 domain-containing protein OS=Capitella teleta... [more]
C1BMP01.236e-1927.51DNA replication complex GINS protein PSF3 OS=Calig... [more]
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BLAST of Sld5 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
gins33.814e-1727.22GINS complex subunit 3 [Source:NCBI gene;Acc:11119... [more]
gins34.332e-1727.22GINS complex subunit 3 [Source:NCBI gene;Acc:11119... [more]
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BLAST of Sld5 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Sld5 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
PSF32.146e-823.08Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, ... [more]
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BLAST of Sld5 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO349051.073e-2030.29Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Sld5 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
gins38.685e-1930.00GINS complex subunit 3 [Source:NCBI gene;Acc:10115... [more]
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BLAST of Sld5 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000002897.14.543e-15699.51SMESG000002897.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30028865 ID=SMED30028865|Name=Sld5 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=647bp
TATATAAATCTTATATGCTGGAATGGATTATAATGATGACTTTAGTCTTT
ACCATGCAGGCAATTATTTCAATATTGATGATATCTTAGCTACCAATGCA
AAATGTCCTTGTATTATTAATGCAAATATGCCTTCCGTTGGTTGTTTAAA
TTCTGCTAAAACTAGTACCGCTGACTTAATAGAAACAATGAAAGCTGAGT
TGCCACTGTGGCTAGTTGAAGGACTTGTTCCAAAAAATGTAGTAACTCCA
CTATTGCCGAATTTTTATAATGAAAATTATCGCAAAATTTACGCCGCTGA
TCCCGCGTATCGCAATGTCAGAAATTGGTCTCCATATTTTTATCAAATTT
GTTGGCATTATTTGCGGATGGAATATTTCCCAGAAACTAAAGATATTGCA
ATTGCAGTTTCAAAATTACTCCAGGAAAGAATGAATTCAATCGTTAGCAA
CGCATTTTTCGCCGATGAGAAATCTTTTACAAAAGAAAAGTCAAAGATGG
ATTCATTGGAACAGGGCATTTTTCAGCAACTATTCGAGACGCGATTGGAA
ACTCAAGATTGGCTAGTCGGTGCTACTCAAGCTGCCAACATCAAGTCGAA
CAGCAATAAATCTTTAAAGCGACATTTTCCTTTTGATGAATAAATAT
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protein sequence of SMED30028865-orf-1

>SMED30028865-orf-1 ID=SMED30028865-orf-1|Name=SMED30028865-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=207bp
MDYNDDFSLYHAGNYFNIDDILATNAKCPCIINANMPSVGCLNSAKTSTA
DLIETMKAELPLWLVEGLVPKNVVTPLLPNFYNENYRKIYAADPAYRNVR
NWSPYFYQICWHYLRMEYFPETKDIAIAVSKLLQERMNSIVSNAFFADEK
SFTKEKSKMDSLEQGIFQQLFETRLETQDWLVGATQAANIKSNSNKSLKR
HFPFDE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000420parapharyngeal region
PLANA:0000429neoblast
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR038437GINS_Psf3_sf
IPR010492GINS_Psf3
IPR036224GINS_bundle-like_dom_sf
IPR021151GINS_A
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
Vocabulary: biological process
TermDefinition
GO:0006260DNA replication
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR021151GINS subunit, domain APFAMPF05916Sld5coord: 60..165
e-value: 1.7E-6
score: 28.4
IPR038437GINS complex, subunit Psf3 superfamilyGENE3DG3DSA:1.20.58.2050coord: 5..185
e-value: 6.5E-36
score: 125.6
IPR010492GINS complex, subunit Psf3PANTHERPTHR22768UNCHARACTERIZEDcoord: 16..196
NoneNo IPR availableCDDcd11713GINS_A_psf3coord: 76..185
e-value: 9.79107E-15
score: 65.3651
NoneNo IPR availableSUPERFAMILYSSF160059PriA/YqbF domaincoord: 13..80
IPR036224GINS, helical bundle-like domain superfamilySUPERFAMILYSSF158573GINS helical bundle-likecoord: 80..184