Condensin complex subunit 1

Query: 1653 IQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIE-DGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSE--KLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQ----FMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGV----EDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDND 3752
            I  M+     + V E I FFV      F V     G+R+MLP I SK+  +R A+ NAYR LYL  + D    + Q +I +LS L+V+ + G   C++ ++  F +  +L  AV + +W R+         L++  S +L  M+A      +    + L++ G+    F + D +L    C AI N    RK    K   PFRLP+ H LF+RL       F     L WI      +  IY LAE P ++ ++++   +K+  E    K  S ++  +       F+L   + +AG +A++Q +H + ++  EL RR  + EE++   K     K+K   + TT       +EEELGLVGATADD EAE IR +CE  L+ D  + L   + +++ +C N   + + DL   ASL+LGK  +IS+  C   + LLF +  +SP   +R+NL+V  GDL  RF   ++P+TP+LY+RLRDP+  VR     V++HLIL DM+KVKGQ+SEM   +ID   +I  L+K FF EL++K  A+YN++PDIISRLS  E GV E+ F TIM+ L+ +I K  QTE+L EK+  R + S  ER  RDL++C+S +P  +  LR +  N + F  KL  + +  A   ++   ++ AK E  A+I+E    +     +G+    E E   + +QR    K + +  +R   + +   DND
Sbjct:  641 ISKMMYENTTTVVQEVIEFFVMV--FQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERA-TEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGL-DEKFPQ-DYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPL-WIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKD---PKEKNTSSETT-------MEEELGLVGATADDTEAELIRGICEMELL-DGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFSAFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAK-KPSTGSRYQPLASTASDND 1336          

Query:   72 MEEFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILN-SHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSV---LDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENP--DFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNS---LIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPY------AQLKTQYDTAKAAVEEMENQIGAMPAESVADVEKHIELL 1484
            M EF +P+  E+L K    NQY V +++++  LP  +   +  FR +G   + + FD +YS+++H+ ++D  +KE +   L+K   +   ++  IL+ +  S  D+  + N LKMN Y L +++E FE    Q   V   L    +K +   A   D  EE +  +  ++QL Q  I   W+  ++E++FV+L+T  CY+LLENP  +  KN   REA++ +L V +  YNH  S+ VK++Q+L  + H+   LV     +       S V +I+ E+      +L RD   +  F++FLTELA+  P  L+  +  L D LD + Y MRN VL  + E+V+QV S +   +A  ++    ++ ++ H  D N FVRS+ L +   I+++  +P    + ++ L VG    ++D S +  KNAI+++   +  +     P+      A L          ++EM  Q     A +V D E+  E +
Sbjct:    5 MYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDIRHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGR---LADKSVLVCKNAIQLLASFLANN-----PFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAM 482          

Query: 1653 IQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIE-DGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSE--KLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQ----FMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLI 2894
            I  M+     + V E I FFV      F V     G+R+MLP I SK+  +R A+ NAYR LYL  + D    + Q +I +LS L+V+ + G   C++ ++  F +  +L  AV + +W R+         L++  S +L  M+A      +    + L++ G+    F + D +L    C AI N    RK    K   PFRLP+ H LF+RL       F     L WI      +  IY LAE P ++ ++++   +K+  E    K  S ++  +       F+L   + +AG +A++Q +H + ++  EL RR  + EE++   KT+   K+K   + TT       +EEELGLVGATADD EAE IR +CE  L+ D  + L   + +++ +C N   + + DL   ASL+LGK  +I
Sbjct:  513 ISKMMYENTTTVVQEVIEFFVMV--FQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERA-TEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGL-DEKFPQ-DYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPL-WIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEH--KTKD-PKEKNTSSETT-------MEEELGLVGATADDTEAELIRGICEMELL-DGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMI 919          

Query:  627 FVNLITNTCYKLLENP--DFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNS---LIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPY------AQLKTQYDTAKAAVEEMENQIGAMPAESVADVEKHIELL 1484
             ++L+T  CY+LLENP  +  KN   REA++ +L V +  YNH  S+ VK++Q+L  + H+   LV     +       S V +I+ E+      +L RD   +  F++FLTELA+  P  L+  +  L D LD + Y MRN VL  + E+V+QV S +   +A  ++    ++ ++ H  D N FVRS+ L +   I+++  +P    + ++ L VG    ++D S +  KNAI+++   +  +     P+      A L          ++EM  Q     A +V D E+  E +
Sbjct:   66 ILHLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGR---LADKSVLVCKNAIQLLASFLANN-----PFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAM 354          

Query:   72 MEEFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEIL-NSHASRDDQCKYRNCLK 410
            M EF +P+  E+L K    NQY V +++++  LP  +   +  FR +G   + + FD +YS+++H+ ++D  +KE +   L+K   +   ++  IL ++  S  D+  + N LK
Sbjct:    5 MYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQELPAILDDTTLSGSDRNAHLNALK 118          

Query: 2703 GATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQ--TENLFEKISTRLQAS--NDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKG-EILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTK 3707
            GAT++D+    +  +C+  L   P+KL+ RLL IVV+  +   K     ++  A+++ GKMM +S+++        F+   +S S  LR NL+    D      T  E +  +L+   +D SP+ R + + VLSHL+ NDMI+ +G LSE   CI D    ++ +++ FF+EL ++   +  ++P+ +  LS+    +S   ++T+ E+L+  ++ K +   +++ +++  +   +  ND  + + L   L+    ND  L  LQ N  +++  +    V      ++ +    +K  E  +   E+  NI K+  +G+  E+  +    +   KGR  K
Sbjct: 1096 GATSNDLH-HLVSVMCDKRLFV-PNKLMGRLLPIVVYGMR--CKIMPTRIRHAATVAYGKMMPLSAEISAFAAPSFFSAMTKSSSILLRCNLVAACCDFAFAQPTLFELFAQSLFRMSQDESPLARESTILVLSHLMSNDMIQTRGVLSEAARCICDPTRAVRDVAQSFFKELNSRTDTIIQLLPEFLYHLSNGNERMSFKSYKTVFEFLIQLLKDKPKASADSMIDRVCIKFSNTDMNDSETPKYLLVALAKFVQNDGGLHRLQDNWRHWSKFMCHPSVAKEYRMMVEHMHSTSKNDEFKSQCVELIDNINKIESEGLRKEDV-AIGSSITKNKGRAKK 1430          

Query: 2481 FMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDG--TLNI------------------EEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNI-----VKLRDKGVEDEEANSSAQRVNIKKGRKTKKA 3713
            +++++ I   G++ +K+ +  D+ I   +K R+ +T  +++        K++ +Q  ++      TLN+                  E +  LVGATA+D  AE I  +CE  L+ +P  LL++L   ++ ICK   +F D  LQ+ A+L+L ++M +SS+ C  N+  L N+   + +  ++ N +V L DL  RF   +EP+T + Y++L + +  +RL  + +LSHLILN+MI+VKGQ+++M  CI+D N  I++++K FF+E+ANK   LYNV+PDIISRL      + EDK+R IM Y++  IQK  Q E L EK+  R   +  ER WRD+++CL L+ +N+  ++ L  N+ ++  K+ VDEV  +   II+N  K AK E+ AV+ E    +     V        D+E+    Q    +   +TKK 
Sbjct:  918 YLVSRLIFCIGYMTIKEMIFLDMDIYNNMKYRDELTALEER--------KNRNQQAGSSHNAARLTLNMSAMEVRKRLSGVAAEPQQEPDDDLVGATAEDNIAEEIHGICEDMLLYNPDALLSKLAPFIIEICKRPGEFGDPTLQQAATLALARLMTVSSRFCESNMSFLMNILNLTKNIRIKCNTVVGLSDLTFRFPNIIEPWTGHFYAQLHESNTELRLTAVKMLSHLILNEMIRVKGQIADMALCIVDGNEEIRNITKQFFKEIANKSNILYNVLPDIISRLGDINLNLDEDKYRIIMSYILGLIQKDRQIETLVEKLCLRFPVTRVERQWRDIAYCLGLLTYNERAVKKLMDNMQHYRDKVQVDEVYQSFKLIISNTNKLAKPELKAVVTEFENRLNECLQVNPDTAAQGDQESTPEGQGNRTRAAPRTKKG 1345          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKE--KSWDLLLKCCQKSVPKIFEILNSHASRDDQCK--YRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATKMDLFEEIELAING-ISQLF---QCKITQFWDPPVVEDDFVNLITNTCYKLLE-NPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLER----DSQAXXXXXXXLTELAQEFPETLIPILPSL-KDKLDEDPYSMRNCVLTVLGEIVIQVYSKND---ENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYA------QLKTQYDTAKAAV--------------EEMENQIGAMPAESVADVEKHI----ELLKEKVHGDEGTIE-VAPLESQG-------VAREMLEMKLTQSKNVLLVFEQ-------LMEIAFLIDCGVK--------------------DIQSMLTSRVP-----------SDVLEAIFFFVAAKSSNFN-VDAGIRKMLPHICSKDDSIRAAITNAY-RILYLEIEDGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNR 2003
            +F++P+   DL   +S +QYYV ++     +P  +  C++        +I+E FD  YS+I    +     +   +S+DLL    +K    +  +L +     +Q +  Y N  KM ++L    ++   N ++Q         +KK+   +  ++ F   E+     + QLF   QC + + W PPV E+DF+NL+ + CY+ +E  P    N  + + + +IL   IK +N   + PV+++Q+L    H     V      L  E   S+V  IL +    + VD  R    DS  S  FS+FL E +   P  ++P L  L +D LD   +++RNCVL ++G+ V+   +  D   E     N  +E +  H+ D +  VRSK L I   +  +  +P   + R+L+  +G    + D SS+ R+ A+ +I   +     +  PY+      +L+ +++    A+              E++ ++  ++  E +  +E+++    ++  +K   DE  +E + PL  +        + R++  +   Q+ + LL  E+       L++   L+  G K                    D   ++TS  P           +DV EA+  F        +  ++G+++ML  + S D   R A+++AY R+L+   + G     + ++ +LSK +    +G +T +++L+  +   GD+D AVI+ ++ R
Sbjct:    8 QFVLPLNASDLIN-SSGDQYYVKEIFGAQEIPAKLQECKRKVHLGDPFYIFEHFDLYYSIIEARGSDGASAQNLMRSFDLLYLTVEKLFQDLQPLLTASEPMSNQQRNSYLNLTKMTLFLQVSTVKKINNSVQQAMRDQQLNVQKKRAKPSEGLEQFPNWEVKRGKFLVQLFNVLQCPLEKLWSPPVAEEDFINLLCDPCYRTIELLPLRMDNKHVFDTIFQILGTSIKRFNQAMTFPVRILQILRGTEHAAHS-VAAGILLLHEEYGISSVFSILIK----SIVDALRMDSSDSSVSKHFSNFLAEFSNIAPSLIVPHLEKLAEDLLDCQSHTLRNCVLQIIGDTVVSELTSEDLSEELKEVRNEFLEHLMAHILDISAHVRSKVLSIWHHLKTQHAIPLNFLTRVLEEAIGR---LEDKSSLVRRAAMHLIKSAL-----ESNPYSSKLSIDELRAKHEHEVQAMEKLNEVLEEERKQEEKLNDEFSSLAPELLPFIEENLTEFPDMQFDKEESDETLMERIIPLMREKNYKDVIVLVRKVDFLAGNQNMSSLLKHEEHCVYVLALLKTYHLLAAGFKQSSEEMLQQIKTVQFLKDSIDFAVLMTSAFPKLHEMLMSKTNTDVFEAVDLFTTGYMFGIHGTESGMQRMLQLVWSSDKEKRDAVSDAYKRVLFSTDQTGRAHAIK-VVQNLSKFLSEIEYGHYTALESLMTEWVLGGDIDAAVIQVLFER 723          

Query: 1623 AFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAA-KSSNFNVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDRNQ--LIIDSLSKLVVNPTFGEFTCVKNLVVNFTES-GDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEW---------NSLKSGSDQ-NHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLN--IEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVE-------DEEANSSAQRVN----------IKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSDASIDDNQ----SIASSRQRRT 3884
            A  ++  +  I +ML  +  + V EA+ F V A + S  +   G+RKMLP + S D +I+ A+  AYR LYL   +GE+ R +   ++DSLS L+V+ + G   C++ +V  F  S   L  +V++ +W R      +   L ++ + +L  M     +  +    + L +  +     E  D  L     I I N     +  K   PFRLP  H LF   L+  I+    +S  +W T   + +  IY LAESP+ L S+L+   ++ L E          + L+ G+ Q +    N   L + + + G +A  Q  H + S+              +  ++  +  + + ++ A   K G  +  +EEELGLVGA+A+D EAEFIRK+CE  L+ +   +L+  L ++V +C +  K+    L   A L+L + M+IS  VC D+I LLF +  +S    +RAN IV LGDL  RF   LEP+TPNLY+RL D +  VRL  + VL+ L+L D++KVKGQ+SE+   ++D    I  L+  FF EL+ KD A+YN++PDIISRLS  E G++E+ F TIM+ L  +I K+ QTE+L EK+  R + +  ER W DL+  LSL+   +   + LQ   + ++ KL    V   +  I    ++ AK +  A +E+    +  +  KG+E       +++A++ +Q ++            +GR   K  ++ +VT  K      P+    +            EE+ DA + +++    +   +R RRT
Sbjct:  615 ALQVERAIAVINNMLYWKTTTIVQEAVQFCVTAFEFSVADSVCGVRKMLPLVWSTDVTIKDAVIQAYRRLYLN-PNGENTRAKAHTLVDSLSDLMVDASLGTIQCLEEIVQEFFSSESALQTSVMQVLWERFS-GKRETKALHRRAAVLLLGMAGRAEREVVLSNLDTLCSVALGEKVAE--DYLLARDTLITITNITDHVRQSK-GVPFRLPMDHHLFS-CLSQAIADGVVQSDPHWQTFMEQAVRLIYFLAESPDQLCSRLLQRSARLLLEQITEGGEPDQSQLQEGASQVSEEQVNCVSLAQVLSLCGAVAFWQVSHLERSV------------SSELRRRRGEKEEKEEKEKAPASKKGANDSCVEEELGLVGASAEDTEAEFIRKICETELLAE-GNMLSAFLPLLVKVCSSPGKYSHPQLTTAACLALSQYMMISPAVCKDHIRLLFTVLEKSQLPVVRANTIVALGDLTVRFPNILEPWTPNLYARLSDENASVRLTAITVLTQLVLKDVMKVKGQVSEVAVLLLDPEPHIASLALNFFNELSAKDNAIYNLLPDIISRLSDPERGMNEEDFNTIMKQLFSYITKERQTESLVEKLCQRFRTAKTERQWADLAVSLSLLSVCERGFKKLQECWDCYSDKLAEPGVYQPLLSIAAKLRRRAKPQFKAQVEDYEKRLTAVHTKGLENVENEEREQQADTQSQNLHTPQAPKSVRRTTRGRGKPKVDDSDLVTPRKSRARPKPAITFTSD----------EEEEEDAVMAESETPKVTTPIARTRRT 1376          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQK---SVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATKMDLFE---EIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFC--KNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSK---NDENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEM 1418
            +F++P+C +DL K  + NQY V  +++   LP HI   +   R +G   I E FD  YSV+ H   VD+ +KE   +LL++  +    S+P +  ++    S  D+ +  N +KM+++LLC++ E+ E++  + ++++    + +KK  A   DL +   E +  +  ++QL Q  I   W   +VE++FV+ +T  CYKLLENP     KN   R+A+  +L +M+K YNH   + VK++QLL  +  + +        +       + V +I+ E+   +S +L R+     +FSSFL+EL    PET+IP +  L   L+ +  S+R  V  +LGE++++V S    +D   A+ +  ++ +++H+ D++  VR++ L +   I+    +P      +++L VG  G   D S    K+AI+++   +  +     PY+   +  D  K   +EM
Sbjct:    4 DFMVPVCLDDLVKSGAVNQYVVQDVLSAKQLPSHINSFKAAMRSQGPLSILEHFDTAYSVLKHCRTVDVAVKEDILELLIQVVRGLSVSLPTL--LMAGTLSAVDRKQQLNAVKMSVFLLCKLTEMLESDSNR-ETIVTAPSKGRKKDKAAGKDLLQWDSERDTVLQCLTQLLQLDIRTLWSLSLVEEEFVSCVTCCCYKLLENPTISHMKNKSTRDAIIHVLGIMVKKYNHMLGACVKVIQLLQHFEQLASVCAQAVAAWSTEYGVKAIVGEIMREIGQKSSEELAREGSGVKAFSSFLSELGTLVPETMIPNISVLLTHLEGESPSLRVAVCEILGEVLVRVLSGDKLDDSARASRDRFLDTLQEHIHDAHSHVRARVLQVYTRIVNSKALPLSRYTEVMELTVGRLG---DKSVNVCKSAIQLLAAFIAHN-----PYSCKLSSVDLKKPLEKEM 450          

Query: 1623 AFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAA-KSSNFNVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDRNQL--IIDSLSKLVVNPTFGEFTCVKNLVVNFTES-GDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEW---------NSLKSGSDQ-NHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLN--IEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGV-----EDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRI-----HEEDSDASIDDNQ----SIASSRQRRT 3884
            A  ++  +  I +ML  +  + V EA+ F V A + S  +   G+RKMLP + S D +I+ A+  AYR LYL   +GE+ R +   ++DSLS L+V+ + G   C++ +V  F  S   L  +V++ +W R      +   L ++ + +L  M     +  +    + L +  +     E  D  L     I I N     +  K   PFRLP  H LF   L+  I+    +S  +W T   + +  IY LAESP+ L S+L+   ++ L E          + L+ G+ Q +    N   L + + + G +A  Q  H + S+              +  ++  +  + + ++ A   K G  +  +EEELGLVGA+A+D EAEFIRK+CE  L+ +   +L+  L ++V +C +  K+    L   A L+L + M+IS  VC D+I LLF +  +S    +RAN IV LGDL  RF   LEP+TPNLY+RL D +  VRL  + VL+ L+L D++KVKGQ+SE+   ++D    I  L+  FF EL+ KD A+YN++PDIISRLS  E G++E+ F TIM+ L  +I K+ QTE+L EK+  R + +  ER W DL+  LSL+   +   + LQ   + ++ KL    V   +  I    ++ AK +  A +E+    +  +  KG+     E+ E  +  Q  N+   +  K  R T   T+ +       S+ +  +  R      I      EE+ DA + +++    +   +R RRT
Sbjct:  639 ALQVERAIAVINNMLYWKTTTIVQEAVQFCVTAFEFSVADSVCGVRKMLPLVWSTDVTIKDAVIQAYRRLYLN-PNGENTRAKAHTLVDSLSDLMVDASLGTIQCLEEIVQEFFSSESALQTSVMQVLWERFS-GKRETKALHRRAAVLLLGMAGRAEREVVLSNLDTLCSVALGEKVAE--DYLLARDTLITITNITDHVRQSK-GVPFRLPMDHHLFS-CLSQAIADGVVQSDPHWQTFMEQAVRLIYFLAESPDQLCSRLLQRSARLLLEQITEGGEPDQSQLQEGASQVSEEQVNCVSLAQVLSLCGAVAFWQVSHLERSV------------SSELRRRRGEKEEKEEKEKAPASKKGANDSCVEEELGLVGASAEDTEAEFIRKICETELLAE-GNMLSAFLPLLVKVCSSPGKYSHPQLTTAACLALSQYMMISPAVCKDHIRLLFTVLEKSQLPVVRANTIVALGDLTVRFPNILEPWTPNLYARLSDENASVRLTAITVLTQLVLKDVMKVKGQVSEVAVLLLDPEPHIASLALNFFNELSAKDNAIYNLLPDIISRLSDPERGMNEEDFNTIMKQLFSYITKERQTESLVEKLCQRFRTAKTERQWADLAVSLSLLSVCERGFKKLQECWDCYSDKLAEPGVYQPLLSIAAKLRRRAKPQFKAQVEDYEKRLTAVHTKGLENVENEEREQQADTQSQNLHTPQAPKSVRRT---TRGRGKPKVDDSDLVTPRKSRARPKPAITFTSDEEEEEDAVMAESETPKVTTPIARTRRT 1400          

Query:   24 KFELFYSLIFIQILYFMEE----FIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQK---SVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATKMDLFE---EIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFC--KNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSK---NDENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEM 1418
            K  +F   +++  L+   E    F++P+C +DL K  + NQY V  +++   LP HI   +   R +G   I E FD  YSV+ H   VD+ +KE   +LL++  +    S+P +  ++    S  D+ +  N +KM+++LLC++ E+ E++  + ++++    + +KK  A   DL +   E +  +  ++QL Q  I   W   +VE++FV+ +T  CYKLLENP     KN   R+A+  +L +M+K YNH   + VK++QLL  +  + +        +       + V +I+ E+   +S +L R+     +FSSFL+EL    PET+IP +  L   L+ +  S+R  V  +LGE++++V S    +D   A+ +  ++ +++H+ D++  VR++ L +   I+    +P      +++L VG  G   D S    K+AI+++   +  +     PY+   +  D  K   +EM
Sbjct:    6 KLAVFSFNVYVGRLFSCAEMSWDFMVPVCLDDLVKSGAVNQYVVQDVLSAKQLPSHINSFKAAMRSQGPLSILEHFDTAYSVLKHCRTVDVAVKEDILELLIQVVRGLSVSLPTL--LMAGTLSAVDRKQQLNAVKMSVFLLCKLTEMLESDSNR-ETIVTAPSKGRKKDKAAGKDLLQWDSERDTVLQCLTQLLQLDIRTLWSLSLVEEEFVSCVTCCCYKLLENPTISHMKNKSTRDAIIHVLGIMVKKYNHMLGACVKVIQLLQHFEQLASVCAQAVAAWSTEYGVKAIVGEIMREIGQKSSEELAREGSGVKAFSSFLSELGTLVPETMIPNISVLLTHLEGESPSLRVAVCEILGEVLVRVLSGDKLDDSARASRDRFLDTLQEHIHDAHSHVRARVLQVYTRIVNSKALPLSRYTEVMELTVGRLG---DKSVNVCKSAIQLLAAFIAHN-----PYSCKLSSVDLKKPLEKEM 474          

Query: 2829 SKFKDQDLQKI----ASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQL-SEMTTCIIDENSRIKHLSKIFFQELANKDKAL 3242
            S+FK   +  +    A ++LGK+ L    + M  + +           ++R+N++V + DL  R+T  +  Y PN+ + LRD  P+VR   L +L++L+  + +K KG L       ++D +  I  L +    +L  K   L
Sbjct:  899 SQFKPTSMPTVVRAHAVITLGKLCLQHEDLMMKYLPVFARELEVGTELAVRSNVVVVMCDLCVRYTNTVTRYIPNISACLRDEEPIVREQTLIMLTNLLQEEYVKWKGPLFFRFAVVLVDPDPAIADLCEYCLVDLLLKKSPL 1041          

Query: 2829 SKFKDQDLQKI----ASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQL-SEMTTCIIDENSRIKHLSKIFFQELANKDKAL 3242
            S+FK   +  +    A ++LGK+ L    + M  + +           ++R+N++V + DL  R+T  +  Y PN+ + LRD  P+VR   L +L++L+  + +K KG L       ++D +  I  L +    +L  K   L
Sbjct:  884 SQFKPTSMPTVVRAHAVITLGKLCLQHEDLMMKYLPVFARELEVGTELAVRSNVVVVMCDLCVRYTNTVTRYIPNISACLRDEEPIVREQTLIMLTNLLQEEYVKWKGPLFFRFAVVLVDPDPAIADLCEYCLVDLLLKKSPL 1026          

Query:   81 FIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQK---SVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQ--LQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDF--CKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKN---DENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIV--------------------GLDVQKG-----VPYAQLKTQYDTAKAAVEEMENQIGAMPAES--------------VADVEKHIELLKEKVHGDEGTIEV----APL----ESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDR--NQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSE--KLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVED 3650
            F IP+   DL K     QY V +++ +  L       +  FR  G   I + FD LYS+++H+ ++D  IKE+  +L++K   +    +P I E LN  A +  +  + N LKMN ++L Q++E FE E  +  L +V   GK KK K+ +       E E  +  ++ L Q +I + W   VVE++FV+++T  CYK++ENP+    KN   REAL  +L V +K YNH  S+ VK++QLL  + H+P+ LV+    +         + +I+ E+    S DL R+S    +F++FLTELA+  P  ++P +  L D LD + Y MRN VLTV+GE+V++V S +   +   +  +  ++ +++H+ D N +VR   L I   ++++  +P    + ++ L+VG    + D S    KNAI+++   +                    G  V +      VP A + +  +  +A + E++     +  ES               ++V   + L+  K  G E         AP+    + +  + E+ +  L + + ++         A  I+  +  I  M+     S V E I FFV    S F V     G+R+MLP + SK+  +R A+ +AYR LYL   +GE +R   Q ++ +LS L+V+ + G   C++ +V  F + GD+   VI+ +W +     +  S L+++ + +L  M+       +    + L+  G+     E  D QL    C  I     ++K    K  EPFRLPK H+LF  L      T +    L+W+      +  +Y L E P  + S+++   S      +  +    +       ++LT  + +AG +A++Q +H + ++  EL+RR  + EE++                   +K     +EEELGLVGA+ADD+EAE IRK+C+  L+ +  + L+  L +++ IC N  ++ D DL  +A+L+L K M+ISS  C  ++ LLF L  +SP  S+R+N+++ LGDL  RF   +EP+TPNLY+RLRDPS  VR     V++HLIL DM+KVKGQ+SEM   +I+ +  I  L++ FF EL+NK  A+YN++PDIISRLS  + GV E+ F+TIM+ L+ +I K  QTE+L EK+  R + +  ER WRDL+ CL+L+PF++  LR +Q   + +  KL  D V ++    +   ++ AK E+ A+I+E    + +  +KG+E+
Sbjct:    9 FHIPLAFRDLLKSGGIGQYVVQEVLPVRQLDAQFDAFQSSFRTEGPLCILQHFDTLYSILHHFRSLDTAIKERVLELMVKVASRHASELPAILEDLNLSAPQ--RAAHLNALKMNCFILTQLVEAFEAETYKASLGNVEPSGKGKKAKSKSEGFSWEAERESILQALTHLLQLEIRRLWSMSVVEEEFVSMVTGCCYKMMENPNIVAAKNKSTREALGHLLGVTVKRYNHMLSASVKVIQLLQHFEHLPSVLVHAVSLWATEYGMKPVIGEIMREIGQKCSQDLSRESSGFKAFATFLTELAERIPAIMMPSISVLLDYLDGENYMMRNAVLTVMGEMVLRVLSGDQLEEAEKSTRDQFLDTLQEHIHDVNTYVRCCVLQIYNRVVQEKALPLTRFQSVVTLVVGR---LFDKSVNVCKNAIQLLASFLANNPFTCKVSLLLKMAFCPFGFLVARFQCIYFVPAAVVISPEEEWEAMLPEVQEAFNVVQQESKEEADDDAQDEKCHPSEVLSSLVLIAGKEAGSEQPATTDQDDAPVKPTSDEEQPSAEVQQSDLGKQEMLVQYLSDAHHFAVKIEEAIDVISKMMYETAVSVVQEVIEFFVTV--SQFGVSQALLGVRRMLPLVWSKEPGVREAVLSAYRRLYL-TSNGESERVKAQALVRNLSLLMVDSSAGILQCLEEIVSEFIQKGDIHPTVIQLLWEKFT-QKSPSSALERRAAIMLLGMMTKGQPEIVMSNLDTLVTVGLGEQVQE--DYQLAQEVCNCILKITDSQKPSLGKSTEPFRLPKDHSLFVHL------TEAVAGGLHWLPFKETAVRLVYELGEEPEEICSEILLRCS------HKAEKREPERTPTLPAYLLTHLLSLAGDVALQQVVHLERAVSSELRRRRVLKEEQE------------------AEKANESTMEEELGLVGASADDIEAELIRKICDTELLGE-QQYLSAFLPLILRICNNPGRYNDPDLCTVATLALAKFMMISSDFCDTHLRLLFTLLEKSPLPSVRSNIMIALGDLSIRFPNLIEPWTPNLYARLRDPSREVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIESDQEIAALARNFFNELSNKGNAVYNLLPDIISRLSDPDCGVEEEAFQTIMKQLLSYITKDKQTESLVEKMCHRFRTARTERQWRDLAHCLALLPFSEKGLRKMQDCFDCYGDKLSDDAVYNSFLSTVAKMRRGAKPELKALIDEFEQKLNRCHNKGLEN 1220          

Query: 1623 AFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDR--NQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSE--KLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVED----EEANSSAQRVNIKKGRKTKKARETAI--VTKHK-DNDGEGPSENIVNKSIRKNKAKRIHEEDSD--ASIDDNQSIASSRQ-RRTC 3887
            A  I+  +  I  M+     S V E I FFV    S F V     G+R+MLP + SK+  +R A+ +AYR LYL   +GE +R   Q ++ +LS L+V+ + G   C++ +V  F + GD+   VI+ +W +     +  S L+++ + +L  M+       +    + L+  G+     E  D QL    C  I     ++K    K  EPFRLPK H+LF  L    ++   G S L+W+      +  +Y L E P  + S+++   S K+ + +  +  +         ++LT  + +AG +A++Q +H + ++  EL+RR  + EE++      K+ K ++       K     +EEELGLVGA+ADD+EAE IRK+C+  L+ +  + L+  L +++ IC N  ++ D DL  +A+L+L K M+ISS  C  ++ LLF L  +SP  S+R+N+++ LGDL  RF   +EP+TPNLY+RLRDPS  VR     V++HLIL DM+KVKGQ+SEM   +I+ +  I  L++ FF EL+NK  A+YN++PDIISRLS  + GV E+ F+TIM+ L+ +I K  QTE+L EK+  R + +  ER WRDL+ CL+L+PF++  LR +Q   + +  KL  D V ++    +   ++ AK E+ A+I+E    + +  +KG+E+    EE N        ++  K+K+   T +  V K K +N+ + P      KS RK       +E+SD  A + + ++  +    RRTC
Sbjct:  617 AVKIEEAIDVISKMMYETAVSVVQEVIEFFVTV--SQFGVSQALLGVRRMLPLVWSKEPGVREAVLSAYRRLYL-TSNGESERVKAQALVRNLSLLMVDSSAGILQCLEEIVSEFIQKGDIHPTVIQLLWEKF-TQKSPSSALERRAAIMLLGMMTKGQPEIVMSNLDTLVTVGLGEQVQE--DYQLAQEVCNCILKITDSQKPSLGKSTEPFRLPKDHSLFVHLTE-AVAGGIGLSGLHWLPFKETAVRLVYELGEEPEEICSEILLRCSHKVLDGHQTQDEAP----TLPAYLLTHLLSLAGDVALQQVVHLERAVSSELRRRRVLKEEQE----AEKVGKQRK------SKANESTMEEELGLVGASADDIEAELIRKICDTELLGE-QQYLSAFLPLILRICNNPGRYNDPDLCTVATLALAKFMMISSDFCDTHLRLLFTLLEKSPLPSVRSNIMIALGDLSIRFPNLIEPWTPNLYARLRDPSREVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIESDQEIAALARNFFNELSNKGNAVYNLLPDIISRLSDPDCGVEEEAFQTIMKQLLSYITKDKQTESLVEKMCHRFRTARTERQWRDLAHCLALLPFSEKGLRKMQDCFDCYGDKLSDDAVYNSFLSTVAKMRRGAKPELKALIDEFEQKLNRCHNKGLENMGVPEEPNPECD----QQPPKSKRPPLTCMNSVKKGKPENEFQTPKPQASRKSRRKVAVTFSSDEESDLEAELSEAETPKNPTPIRRTC 1362          

Query:   81 FIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQK---SVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQ--LQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDF--CKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKN---DENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVG 1340
            F IP+   DL K     QY V +++ +  L       +  FR  G   I + FD LYS+++H+ ++D  IKE+  +L++K   +    +P I E LN  A +  +  + N LKMN ++L Q++E FE E  +  L +V   GK KK K+ +       E E  +  ++ L Q +I + W   VVE++FV+++T  CYK++ENP+    KN   REAL  +L V +K YNH  S+ VK++QLL  + H+P+ LV+    +         + +I+ E+    S DL R+S    +F++FLTELA+  P  ++P +  L D LD + Y MRN VLTV+GE+V++V S +   +   +  +  ++ +++H+ D N +VR   L I   ++++  +P    + ++ L+VG    + D S    KNAI+++   + 
Sbjct:    5 FHIPLAFRDLLKSGGIGQYVVQEVLPVRQLDAQFDAFQSSFRTEGPLCILQHFDTLYSILHHFRSLDTAIKERVLELMVKVASRHASELPAILEDLNLSAPQ--RAAHLNALKMNCFILTQLVEAFEAETYKASLGNVEPSGKGKKAKSKSEGFSWEAERESILQALTHLLQLEIRRLWSMSVVEEEFVSMVTGCCYKMMENPNIVAAKNKSTREALGHLLGVTVKRYNHMLSASVKVIQLLQHFEHLPSVLVHAVSLWATEYGMKPVIGEIMREIGQKCSQDLSRESSGFKAFATFLTELAERIPAIMMPSISVLLDYLDGENYMMRNAVLTVMGEMVLRVLSGDQLEEAEKSTRDQFLDTLQEHIHDVNTYVRCCVLQIYNRVVQEKALPLTRFQSVVTLVVGR---LFDKSVNVCKNAIQLLASFLA 429          

Query: 1749 GIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDR--NQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVED 3650
            G+R+MLP + SK+  +R A+ +AYR LYL   +GE +R   Q ++ +LS L+V+ + G   C++ +V  F + GD+   VI+ +W +     +  S L+++ + +L  M+       +    + L+  G+     E  D QL    C  I     ++K      PFRLPK H+LF  L    ++   G S L+W+      +  +Y L E P  + S+++   S K+ + +  ++  +        ++LT  + +AG +A++Q +H + ++  EL+RR  + EE++      K+ K ++       K     +EEELGLVGA+ADD+EAE IRK+C+  L+ +  + L+  L +++ IC N  ++ D DL  +A+L+L K M+ISS  C  ++ LLF L  +SP  S+R+N+++ LGDL  RF   +EP+TPNLY+RLRDPS  VR     V++HLIL DM+KVKGQ+SEM   +I+ +  I  L++ FF EL+NK  A+YN++PDIISRLS  + GV E+ F+TIM+ L+ +I K  QTE+L EK+  R + +  ER WRDL+ CL+L+PF++  LR +Q   + +  KL  D V ++    +   ++ AK E+ A+I+E    + +  +KG+E+
Sbjct:  541 GVRRMLPLVWSKEPGVREAVLSAYRRLYL-TSNGESERVKAQALVRNLSLLMVDSSAGILQCLEEIVSEFIQKGDIHPTVIQLLWEKFT-QKSPSSALERRAAIMLLGMMTKGQPEIVMSNLDTLVTVGLGEQVQE--DYQLAQEVCNCILKITDSQK------PFRLPKDHSLFVHLTE-AVAGGIGLSGLHWLPFKETAVRLVYELGEEPEEICSEILLRCSHKVLDGH--QTQDEGKAPTLPAYLLTHLLSLAGDVALQQVVHLERAVSSELRRRRVLKEEQE----AEKVGKQRK------SKANESTMEEELGLVGASADDIEAELIRKICDTELLGE-QQYLSAFLPLILRICNNPGRYNDPDLCTVATLALAKFMMISSDFCDTHLRLLFTLLEKSPLPSVRSNIMIALGDLSIRFPNLIEPWTPNLYARLRDPSREVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIESDQEIAALARNFFNELSNKGNAVYNLLPDIISRLSDPDCGVEEEAFQTIMKQLLSYITKDKQTESLVEKMCHRFRTARTERQWRDLAHCLALLPFSEKGLRKMQDCFDCYGDKLSDDAVYNSFLSTVAKMRRGAKPELKALIDEFEQKLNRCHNKGLEN 1152          

Query:  540 EIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDF--CKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKN---DENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVG 1340
            E E  +  ++ L Q +I + W   VVE++FV+++T  CYK++ENP+    KN   REAL  +L V +K YNH  S+ VK++QLL  + H+P+ LV+    +         + +I+ E+    S DL R+S    +F++FLTELA+  P  ++P +  L D LD + Y MRN VLTV+GE+V++V S +   +   +  +  ++ +++H+ D N +VR   L I   ++++  +P    + ++ L+VG    + D S    KNAI+++   + 
Sbjct:   87 ERESILQALTHLLQLEIRRLWSMSVVEEEFVSMVTGCCYKMMENPNIVAAKNKSTREALGHLLGVTVKRYNHMLSASVKVIQLLQHFEHLPSVLVHAVSLWATEYGMKPVIGEIMREIGQKCSQDLSRESSGFKAFATFLTELAERIPAIMMPSISVLLDYLDGENYMMRNAVLTVMGEMVLRVLSGDQLEEAEKSTRDQFLDTLQEHIHDVNTYVRCCVLQIYNRVVQEKALPLTRFQSVVTLVVGR---LFDKSVNVCKNAIQLLASFLA 355          

Query: 1623 AFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDR--NQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSD--ASIDDNQSIASSRQ-RRTC 3887
            A  I+  +  I  M+     S V E I FFV    S F V     G+R+MLP + SK+  +R A+ +AYR LYL   +GE +R   Q ++ +LS L+V+ + G   C++ +V  F + GD+   VI+ +W +     +  S L+++ + +L  M+       +    + L+  G+     E  D QL    C  I   +K   S+K+       +   +    + L  S       L+W+      +  +Y L E P  + S+++   S K+ + +  ++  +        ++LT  + +AG +A++Q +H + ++  EL+RR  + EE++      K+ K ++ ++          +EEELGLVGA+ADD+EAE IRK+C+  L+ +  + L+  L +++ IC N  ++ D DL  +A+L+L K M+ISS  C  ++ LLF L  +SP  S+R+N+++ LGDL  RF   +EP+TPNLY+RLRDPS  VR     V++HLIL DM+KVKGQ+SEM   +I+ +  I  L++ FF EL+NK  A+YN++PDIISRLS  + GV E+ F+TIM+ L+ +I K  QTE+L EK+  R + +  ER WRDL+ CL+L+PF++  LR +Q   + +  KL  D V ++    +   ++ AK E+ A+I+E    + +  +KG+E+          ++KKG+               +N+ + P      KS RK       +E+SD  A + + ++  +    RRTC
Sbjct:  584 AVKIEEAIDVISKMMYETAVSVVQEVIEFFVTV--SQFGVSQALLGVRRMLPLVWSKEPGVREAVLSAYRRLYL-TSNGESERVKAQALVRNLSLLMVDSSAGILQCLEEIVSEFIQKGDIHPTVIQLLWEKFT-QKSPSSALERRAAIMLLGMMTKGQPEIVMSNLDTLVTVGLGEQVQE--DYQLAQEVCNCI---LKITDSQKV-------RWGGMQGVSIYLAFSLVLNGDWLHWLPFKETAVRLVYELGEEPEEICSEILLRCSHKVLDGH--QTQDEGKAPTLPAYLLTHLLSLAGDVALQQVVHLERAVSSELRRRRVLKEEQE----AEKVGKQRKSKS---------TMEEELGLVGASADDIEAELIRKICDTELLGE-QQYLSAFLPLILRICNNPGRYNDPDLCTVATLALAKFMMISSDFCDTHLRLLFTLLEKSPLPSVRSNIMIALGDLSIRFPNLIEPWTPNLYARLRDPSREVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIESDQEIAALARNFFNELSNKGNAVYNLLPDIISRLSDPDCGVEEEAFQTIMKQLLSYITKDKQTESLVEKMCHRFRTARTERQWRDLAHCLALLPFSEKGLRKMQDCFDCYGDKLSDDAVYNSFLSTVAKMRRGAKPELKALIDEFEQKLNRCHNKGLENMGRPPLTCMNSVKKGK--------------PENEFQTPKPQASRKSRRKVAVTFSSDEESDLEAELSEAETPKNPTPIRRTC 1300          

Query:   81 FIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQK---SVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQ--LQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDF--CKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKN---DENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVG 1340
            F IP+   DL K     QY V +++ +  L       +  FR  G   I + FD LYS+++H+ ++D  IKE+  +L++K   +    +P I E LN  A +  +  + N LKMN ++L Q++E FE E  +  L +V   GK KK K+ +       E E  +  ++ L Q +I + W   VVE++FV+++T  CYK++ENP+    KN   REAL  +L V +K YNH  S+ VK++QLL  + H+P+ LV+    +         + +I+ E+    S DL R+S    +F++FLTELA+  P  ++P +  L D LD + Y MRN VLTV+GE+V++V S +   +   +  +  ++ +++H+ D N +VR   L I   ++++  +P    + ++ L+VG    + D S    KNAI+++   + 
Sbjct:    5 FHIPLAFRDLLKSGGIGQYVVQEVLPVRQLDAQFDAFQSSFRTEGPLCILQHFDTLYSILHHFRSLDTAIKERVLELMVKVASRHASELPAILEDLNLSAPQ--RAAHLNALKMNCFILTQLVEAFEAETYKASLGNVEPSGKGKKAKSKSEGFSWEAERESILQALTHLLQLEIRRLWSMSVVEEEFVSMVTGCCYKMMENPNIVAAKNKSTREALGHLLGVTVKRYNHMLSASVKVIQLLQHFEHLPSVLVHAVSLWATEYGMKPVIGEIMREIGQKCSQDLSRESSGFKAFATFLTELAERIPAIMMPSISVLLDYLDGENYMMRNAVLTVMGEMVLRVLSGDQLEEAEKSTRDQFLDTLQEHIHDVNTYVRCCVLQIYNRVVQEKALPLTRFQSVVTLVVGR---LFDKSVNVCKNAIQLLASFLA 429          

Query: 2649 ATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVED 3650
             T  K     +EEELGLVGA+ADD+EAE IRK+C+  L+ +  + L+  L +++ IC N  ++ D DL  +A+L+L K M+ISS  C  ++ LLF L  +SP  S+R+N+++ LGDL  RF   +EP+TPNLY+RLRDPS  VR     V++HLIL DM+KVKGQ+SEM   +I+ +  I  L++ FF EL+NK  A+YN++PDIISRLS  + GV E+ F+TIM+ L+ +I K  QTE+L EK+  R + +  ER WRDL+ CL+L+PF++  LR +Q   + +  KL  D V ++    +   ++ AK E+ A+I+E    + +  +KG+E+
Sbjct:  894 GTLGKICLYTMEEELGLVGASADDIEAELIRKICDTELLGE-QQYLSAFLPLILRICNNPGRYNDPDLCTVATLALAKFMMISSDFCDTHLRLLFTLLEKSPLPSVRSNIMIALGDLSIRFPNLIEPWTPNLYARLRDPSREVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIESDQEIAALARNFFNELSNKGNAVYNLLPDIISRLSDPDCGVEEEAFQTIMKQLLSYITKDKQTESLVEKMCHRFRTARTERQWRDLAHCLALLPFSEKGLRKMQDCFDCYGDKLSDDAVYNSFLSTVAKMRRGAKPELKALIDEFEQKLNRCHNKGLEN 1226          

Query:  336 VPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQ--LQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDF--CKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKN---DENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVG 1340
            +P I E LN  A +  +  + N LKMN ++L Q++E FE E  +  L +V   GK KK K+ +       E E  +  ++ L Q +I + W   VVE++FV+++T  CYK++ENP+    KN   REAL  +L V +K YNH  S+ VK++QLL  + H+P+ LV+    +         + +I+ E+    S DL R+S    +F++FLTELA+  P  ++P +  L D LD + Y MRN VLTV+GE+V++V S +   +   +  +  ++ +++H+ D N +VR   L I   ++++  +P    + ++ L+VG    + D S    KNAI+++   + 
Sbjct:   49 LPAILEDLNLSAPQ--RAAHLNALKMNCFILTQLVEAFEAETYKASLGNVEPSGKGKKAKSKSEGFSWEAERESILQALTHLLQLEIRRLWSMSVVEEEFVSMVTGCCYKMMENPNIVAAKNKSTREALGHLLGVTVKRYNHMLSASVKVIQLLQHFEHLPSVLVHAVSLWATEYGMKPVIGEIMREIGQKCSQDLSRESSGFKAFATFLTELAERIPAIMMPSISVLLDYLDGENYMMRNAVLTVMGEMVLRVLSGDQLEEAEKSTRDQFLDTLQEHIHDVNTYVRCCVLQIYNRVVQEKALPLTRFQSVVTLVVGR---LFDKSVNVCKNAIQLLASFLA 385          

Query: 1623 AFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDR--NQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSE--KLAEPFRLPKTHTLFDRLLNLCISTFSGK--SRLYWITMANETINTIYLLAESP 2378
            A  I+  +  I  M+     S V E I FFV    S F V     G+R+MLP + SK+  +R A+ +AYR LYL   +GE +R   Q ++ +LS L+V+ + G   C++ +V  F + GD+   VI+ +W +     +  S L+++ + +L  M+       +    + L+  G+     E  D QL    C  I     ++K    K  EPFRLPK H+LF   ++L  +   GK  S L+W+      +  +Y L E P
Sbjct:  571 AVKIEEAIDVISKMMYETAVSVVQEVIEFFVTV--SQFGVSQALLGVRRMLPLVWSKEPGVREAVLSAYRRLYL-TSNGESERVKAQALVRNLSLLMVDSSAGILQCLEEIVSEFIQKGDIHPTVIQLLWEKFT-QKSPSSALERRAAIMLLGMMTKGQPEIVMSNLDTLVTVGLGEQVQE--DYQLAQEVCNCILKITDSQKPSLGKSTEPFRLPKDHSLF---VHLTEAVAGGKCLSGLHWLPFKETAVRLVYELGEEP 822          

Query: 1653 IQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIE-DGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAE---PFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPN---XXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVG-ATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDK---GVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKR 3812
            I  M+     + V E I FFV      F V     G+R+MLP I SK+  +R A+ NAYR LYL  + D    + Q +I +LS L+V+ + G   C++ ++  F +  ++  AVI+ +W R+       S L++  S +L  M+A      +    + L+  G+     +  D +L    C+AI N +  R+   L E   PFRLP+ H LF+RL ++    F+    L WI      +   Y LAESP+       +  +    +  E N+ ++   +       F+L   + +AG +A++Q +H + ++  EL RR  + EE++        AK+ + +TA+++      +EEELGLVG ATADD EAE IR +CE  L+ D +++L   + +++ +C N   + + +L   ASL+LGK  +IS+  C   + LLF +  +S   ++R+NL+V  GDL  RF   ++P+TP+LY+RLRDP+  VR     V++HLIL DM+KVKGQ+SEM   +ID   +I  L+K FF EL++K  A+YN++PDIISRLS  E GV E+ F TIM+ L+ +I K  QTE+L EK+  R + +  ER +RDL++C+S +P  +  L+ +  N   F  KL  + V  A   ++   ++ AK E  A+I+E    +     +   G+E+ E      +  +   + +  +R   + +   DND        V    R+ K  R
Sbjct:  631 ISKMMYENTTTVVQEVIEFFVMV--FQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQTLIHNLSLLLVDASVGTIQCLEEILCEFVQKDEVKPAVIQLLWERA-TEKVPSSPLERCSSVMLLGMMARGKPEIVGSNLDALVRVGLDEKSPQ--DYRLAQQVCLAIAN-ISDRRKPSLGERHPPFRLPQEHRLFERLQDMVTKGFAHPDPL-WIPFKEVAVTLTYQLAESPDVLCAQMLQGCAKQVLEKLEKNATEADPKETAPRLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELGRRRVLREEQEHR------AKEPKEKTASSET----TMEEELGLVGGATADDTEAELIRSICEKELL-DGNQVLAAFVPLLLKVCNNPGLYSNPELCAAASLALGKFCMISAPFCDSQLRLLFTMLEKSSLPTVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPEGGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQYRDLAYCMSQLPLTERGLQKMLDNFECFGDKLLDESVFSAFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGMDGIEEFETGQGGSQRALSAKKPSAVSRLQPLTSVDSDND-------FVTPKPRRTKPGR 1339          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHA-SRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATK----MDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFC--KNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKND-ENSA--NFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVG 1340
            EF +P+  E+L K    NQY V +++ +  L   +   +  FR +G   I E FD +YS+++H+ +++  +KE + + L K   +   ++  IL+  A S  D+  + N LKMN Y L +++E FEN M    S++D     K K    K     D  EE +  +  ++QL Q  I   W+   +E++FV+L+T  CY+LLENP     KN   +EA++ +L V +  YNH  S+ VK++Q+L  + H+P  LV     +       S V +I+ E+      +L RD+  +  F++FLTELA+  P  L+  +  L D LD + Y MRN VL  + E+V+QV + +  E SA    +  +++++ H  D N FVRS+ L +   I+++  +P    + ++ L VG    ++D S +  KNAI+++   + 
Sbjct:    7 EFHLPLSPEELLKSGGVNQYVVREVLPVKHLSSQLRAFQSAFRAQGPLAILEHFDTVYSILHHFRSIEPGLKEDTLEFLKKVVSRHSQELSSILDDAALSGSDRSAHLNALKMNCYALIRLLESFEN-MTSQTSLIDLDIGGKGKRARAKATLGFDWEEERQPVLQLLTQLLQLDIRHLWNHSAIEEEFVSLVTGCCYRLLENPTISHQKNRSTKEAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHLPPVLVTAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDTAGAKGFAAFLTELAERIPAVLMANMCILLDHLDGENYMMRNAVLAAIAEMVLQVLNGDQLEESARETRDQFLDILQAHGHDVNSFVRSRVLQLFARIVQQKALPLTRFQAVVALAVGR---LADKSVLVCKNAIQLLASFLA 433          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHA-SRDDQCKYRNCLKMNIYLLCQMIELFENEMRQ 467
            EF +P+  E+L K    NQY V +++ +  L   +   +  FR +G   I E FD +YS+++H+ +++  +KE + + L K   +   ++  IL+  A S  D+  + N LKMN Y L +++E FEN   Q
Sbjct:    7 EFHLPLSPEELLKSGGVNQYVVREVLPVKHLSSQLRAFQSAFRAQGPLAILEHFDTVYSILHHFRSIEPGLKEDTLEFLKKVVSRHSQELSSILDDAALSGSDRSAHLNALKMNCYALIRLLESFENMTSQ 137          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLK 320
            EF +P+  E+L K    NQY V +++ +  L   +   +  FR +G   I E FD +YS+++H+ +++  +KE + + L K
Sbjct:    7 EFHLPLSPEELLKSGGVNQYVVREVLPVKHLSSQLRAFQSAFRAQGPLAILEHFDTVYSILHHFRSIEPGLKEDTLEFLKK 87          

Query: 1482 LKEKVHGDEGTIEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDR--NQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSE--KLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHW-DCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGV------EDEEANSSAQ----------RVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSD 3833
            L++    D+   +V P   +  ++E+    + + + ++         A  I+  +  I  M+     S V E I FFV    S F V     G+R+MLP + SK+  +R A+ +AYR LYL   +GE +R   Q ++ SLS L+V+ + G   C++ +V  F + GD+  +VI+ +W +     +  S  +++ + +L  M+       +    + L++ G+      + D QL    C  I     ++K    K  EPFRLPK H+LF   L   ++   G S L+W+      +  +Y L E P  + S+++   S+     N L     Q+   +   F+LT  + +AG +A++Q +H + ++  EL+RR  + EE++      K+ K ++       K     +EEELGLVGA+ADD+EAE IRK+C+  L+    + L+  L +++ IC N  ++ D DL  +A+L+L K M+ISS  C  ++ LLF L  +SP  S+R+N+++ LGDL  RF   +EP+TPNLY+RLRDPS  VR     V++HLIL DM+KVKGQ+SEM   +I+ +  I  L++ FF EL+NK  A+YN++PDIISRLS  + GV E+ FRTIM+ L+ +I K  QTE+L EK+  R + +  ER WRDL+ CLSL+PF++  LR +Q   + +  KL  + V ++    +   ++ AK E+ A+I+E    + +  +KG+      E+  A S AQ           VN+KKG+               ++D + P      KS RK       +E+SD
Sbjct:  568 LEQPTTKDQDDAQVNPTSEELPSQEVQNSDMDKQEMLVQYLSDAHHFALKIEEAIDVISKMMYETAVSVVQEVIEFFVTV--SQFGVSQALLGVRRMLPLVWSKEPGVREAVLSAYRRLYLS-SNGESERVKAQALVRSLSLLMVDSSAGILQCLEEIVSEFVQKGDIHPSVIQLLWEKF-TQKSPCSEFERRAAVMLLGMMTRGQPEIVMSNLDTLVSVGLGEQV--QKDYQLAREVCNCILKITDSQKQTLGKSTEPFRLPKDHSLF-VCLTEAVAGGIGLSGLHWLPFKETAVRLVYELGEEPEEICSEILLRCSQ-----NVLDGHQTQDEVPNVPAFLLTHLLSLAGDVALQQVVHLERAVSAELRRRRVLKEEQE----AEKVGKQRK------SKANESTMEEELGLVGASADDIEAELIRKICDTELLGG-QQYLSAFLPLILRICNNPGRYSDPDLCTVATLALAKYMMISSDFCDTHLRLLFTLLEKSPLPSVRSNIMIALGDLSIRFPNLIEPWTPNLYARLRDPSREVRKTAGMVMTHLILKDMVKVKGQVSEMAVLLIESDQEISALARNFFNELSNKGNAVYNLLPDIISRLSDPDCGVEEEAFRTIMKQLLSYITKDKQTESLVEKMCHRFRTARTERQWRDLAHCLSLLPFSEKGLRKMQDCFDCYGDKLSDEAVYNSFLTTVAKMRRGAKPELKALIDEFEQKLSRCHNKGLENMDVPEEPSAESDAQPPKAKRPPLASVNVKKGK--------------SEDDFQTPKPPASRKSRRKVAVNFSSDEESD 1338          

Query:   81 FIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQK---SVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQ--LQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPD--FCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNS---LIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVG 1340
            F IP+   DL K     QY V +++ +  +       +  FR      I + FD LYS+++H+ ++D+ IKE   ++++K   +    +P I E LN   S   +  + N LKMN ++L Q+IE FE E  +  L SV   GK KK K+         E E  +  ++ L Q  I + W   VVE++FV+++T+ CYK++ENP+    KN   REAL  +L V +K YNH  S+ VK++QLL  + H+ + LV+    +         + +I+ E+    S DL R+S    +F++FLTELA+  P  ++P +  L D LD + Y MRN VLTV+GE+V++V S +    A  +S    ++ +++HL D N +VRS  + I   I+++  +P    + ++ L+VG    + D S    KNAI+++   + 
Sbjct:    5 FHIPLAFRDLLKSGGIGQYVVQEVLPVRHVDAQFAAFQTSFRTEAPLCILQHFDTLYSILHHFRSLDIAIKEDVLEVMVKVASRHANELPAILEDLN--LSVPQRAAHLNALKMNCFILTQLIEAFEAETYKASLGSVEPSGKGKKAKSKPEGFSWESERESILQALTHLLQLDIRRLWSMSVVEEEFVSMMTSCCYKMMENPNIVMAKNKSTREALGHLLGVTVKRYNHMLSASVKVIQLLQHFEHLASVLVHTVSLWATEYGMKPVIGEIMREIGQKCSQDLSRESSGFKAFATFLTELAERIPAIMMPSISVLLDYLDGENYMMRNSVLTVMGEMVVRVLSGDQLEEAEKSSRDQFLDTLQEHLHDVNTYVRSCVIQIYNRIVQEKALPLSRFQSVVTLVVGR---LFDKSVNVCKNAIQLLASFLA 429          

Query: 1653 IQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIE-DGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAE---PFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPN---XXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVG-ATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDK---GVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKR 3812
            I  M+     + V E I FFV      F V     G+R+MLP I SK+  +R A+ NAYR LYL  + D    + Q +I +LS L+V+ + G   C++ ++  F +  ++  AVI+ +W R+       S L++  S +L  M+A      +    + L+  G+     +  D +L    C+AI N +  R+   L E   PFRLP+ H LF+RL ++    F+    L WI      +   Y LAESP+       +  +    +  E N+ ++   +       F+L   + +AG +A++Q +H + ++  EL RR  + EE++        AK+ + +TA+++      +EEELGLVG ATADD EAE IR +CE  L+ D +++L   + +++ +C N   + + +L   ASL+LGK  +IS+  C   + LLF +  +S   ++R+NL+V  GDL  RF   ++P+TP+LY+RLRDP+  VR     V++HLIL DM+KVKGQ+SEM   +ID   +I  L+K FF EL++K  A+YN++PDIISRLS  E GV E+ F TIM+ L+ +I K  QTE+L EK+  R + +  ER +RDL++C+S +P  +  L+ +  N   F  KL  + V  A   I+   ++ AK E  A+I+E    +     +   G+E+ E      +  +   + +  +R   + +   DND        V    R+ K  R
Sbjct:  631 ISKMMYENTTTVVQEVIEFFVMV--FQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQTLIHNLSLLLVDASVGTIQCLEEILCEFVQKDEVKPAVIQLLWERA-TEKVPSSPLERCSSVMLLGMMARGKPEIVGSNLDALVRVGLDEKSPQ--DYRLAQQVCLAIAN-ISDRRKPSLGERHPPFRLPQEHRLFERLQDMVTKGFAHPDPL-WIPFKEVAVTLTYQLAESPDVLCAQMLQGCAKQVLEKLEKNATEADPKETAPRLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELGRRRVLREEQEHR------AKEPKEKTASSET----TMEEELGLVGGATADDTEAELIRSICEKELL-DGNQVLAAFVPLLLKVCNNPGLYSNPELCAAASLALGKFCMISAPFCDSQLRLLFTMLEKSSLPTVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPEGGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQYRDLAYCMSQLPLTERGLQKMLDNFECFGDKLLDESVFSAFLSIVGKLRRGAKPEGKAIIDEFEQKLRACHTRGMDGIEEFETGQGGSQRALSAKKPSAVSRLQPLTSVDSDND-------FVTPKPRRTKPGR 1339          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHA-SRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATK----MDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFC--KNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKND-ENSA--NFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVG 1340
            EF +P+  E+L K    NQY V +++ +  L   +   +  FR +G   I E FD +YS+++H+ +++  +KE + + L K   +   ++  IL+  A S  D+  + N LKMN Y L +++E FEN M    S++D     K K    K     D  EE +  +  ++QL Q  I   W+   +E++FV+L+T  CY+LLENP     KN   +EA++ +L V +  YNH  S+ VK++Q+L  + H+P  LV     +       S V +I+ E+      +L RD+  +  F++FLTELA+  P  L+  +  L D LD + Y MRN VL  + E+V+QV + +  E SA    +  +++++ H  D N FVRS+ L +   I+++  +P    + ++ L VG    ++D S +  KNAI+++   + 
Sbjct:    7 EFHLPLSPEELLKSGGVNQYVVREVLPVKHLSSQLRAFQSAFRAQGPLAILEHFDTVYSILHHFRSIEPGLKEDTLEFLKKVVSRHSQELSSILDDAALSGSDRSAHLNALKMNCYALIRLLESFEN-MTSQTSLIDLDIGGKGKRARAKATLGFDWEEERQPVLQLLTQLLQLDIRHLWNHSAIEEEFVSLVTGCCYRLLENPTISHQKNRSTKEAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHLPPVLVTAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDTAGAKGFAAFLTELAERIPAVLMANMCILLDHLDGENYMMRNAVLAAIAEMVLQVLNGDQLEESARETRDQFLDILQAHGHDVNSFVRSRVLQLFARIVQQKALPLTRFQAVVALAVGR---LADKSVLVCKNAIQLLASFLA 433          

Query: 1653 IQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIE-DGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSE--KLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQ----FMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGV----EDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDND 3752
            I  M+     + V E I FFV      F V     G+R+MLP I SK+  +R A+ NAYR LYL  + D    + Q +I +LS L+V+ + G   C++ ++  F +  +L  AV + +W R+         L++  S +L  M+A      +    + L++ G+    F + D +L    C AI N    RK    K   PFRLP+ H LF+RL       F     L WI      +  IY LAE P ++ ++++   +K+  E    K  S ++  +       F+L   + +AG +A++Q +H + ++  EL RR  + EE++   K     K+K   + TT       +EEELGLVGATADD EAE IR +CE  L+ D  + L   + +++ +C N   + + DL   ASL+LGK  +IS+  C   + LLF +  +SP   +R+NL+V  GDL  RF   ++P+TP+LY+RLRDP+  VR     V++HLIL DM+KVKGQ+SEM   +ID   +I  L+K FF EL++K  A+YN++PDIISRLS  E GV E+ F TIM+ L+ +I K  QTE+L EK+  R + S  ER  RDL++C+S +P  +  LR +  N + F  KL  + +  A   ++   ++ AK E  A+I+E    +     +G+    E E   + +QR    K + +  +R   + +   DND
Sbjct:  641 ISKMMYENTTTVVQEVIEFFVMV--FQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERA-TEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVSIGL-DEKFPQ-DYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPL-WIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKD---PKEKNTSSETT-------MEEELGLVGATADDTEAELIRGICEMELL-DGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFSAFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAK-KPSTGSRYQPLASTASDND 1336          

Query:   72 MEEFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILN-SHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSV---LDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENP--DFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNS---LIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPY------AQLKTQYDTAKAAVEEMENQIGAMPAESVADVEKHIELL 1484
            M EF +P+  E+L K    NQY V +++++  LP  +   +  FR +G   + + FD +YS+++H+ ++D  +KE +   L+K   +   ++  IL+ +  S  D+  + N LKMN Y L +++E FE    Q   V   L    +K +   A   D  EE +  +  ++QL Q  I   W+  ++E++FV+L+T  CY+LLENP  +  KN   REA++ +L V +  YNH  S+ VK++Q+L  + H+   LV     +       S V +I+ E+      +L RD   +  F++FLTELA+  P  L+  +  L D LD + Y MRN VL  + E+V+QV S +   +A  ++    ++ ++ H  D N FVRS+ L +   I+++  +P    + ++ L VG    ++D S +  KNAI+++   +  +     P+      A L          ++EM  Q     A +V D E+  E +
Sbjct:    5 MYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAFQAAFRAQGPLAMLQHFDTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQELPAILDDTTLSGSDRNAHLNALKMNCYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLDIRHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGR---LADKSVLVCKNAIQLLASFLANN-----PFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAM 482          

Query:  555 INGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENS------ANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQ--YDTAKAAVEEMENQIGAMPAESVADVEKHIE--LLKEK--VHGDEGTIEVAPLE---SQGV----AREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDAG---IRKMLPHICSKDDS-----IRAAITNAYRILYLEI--EDGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCI-STFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFE-WNSLKSGSDQNHW---DCNQ--------------FMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEE--ELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSED--KFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMP 3455
            ++ I  LFQ K+++ W      D F++L     Y L+E+    KNA  R  L  I+ + ++ +NH  ++   ++Q L  + H+      +        N  +    I+  +C+    D   D +     + FL  L+   P   +  L  L   LD + Y++R  ++ VL  +VI       +N       A   SL++++ + L D + + R+K L + + I +   +P    ++  ++       + D SS  R+NAI++ + ++       V +  L T+  ++   + +EE  N +     E V D E  ++  LL++   +  DE     + LE   S+ V    A E++++ LT+       + + ++   +++ G K I  +L ++  S+V+E++ FFV   S  F + +    I+KM+  I  K  S     I+  + + Y+ L+ E     G ++    I  +L  L  + +  E T ++ ++    + G     VI  +W    Y     S  Q++ S I+  M+A      + +  + LI  G+   G E  DL L  Y CIAI+   +  K    +     P +HTL  +L  L +  +FS +    W  +  + I  IY +A+ P+ L + +I  L+K+LF+  N   + S+ +H    D +                 L   I + GH+A+KQ ++ +     E KRR    E                 + A  + +  +N +E  E  L+  T++D  +E +  + E  L+   + LL+R   +VV +C N     +Q L   ASL+L K M +S+  CM+++ LL  +  +  +  +R NL++ L DL   F   ++  +  LY RL D    V+      L+ LIL   IKVKGQL  M   + DE++RI  L+++FF + A KD ++YN   DI S LS +     ED  KF+ I+ +L  FI+K+  T+ L E+++ RL     +R W  + + LSL+P
Sbjct:  164 LDAIITLFQKKLSRVWTTSSERDMFLSLFLKPIYTLMESEINIKNASFRSRLFNIIGLAVQFHNHTTAAETNIIQNLQYFEHLSEYAADLVHIVTVQFNSVTLAEGIIRTLCSLEFND--NDVKGPKQVALFLVRLSSLIPNLCLKQLTQLVKLLDSESYTLRCAIIEVLANVVIDQIHDEAQNEMSESVPATVQSLMDLLSERLLDISPYCRTKVLHVFIKIFD---LPIKYPRKRQEIAELVIRCLQDRSSHVRRNAIKLFSKLLTTH-PFSVMHNGLLTRNIWEKGLSIIEEQLNSLQPKQQEKVVDSELEVDENLLEDATMIQDDESHEGESHLENSLSEYVDSVPAEEIVKVNLTKR-----FYLEALQYIDIVEAGAKIISQLLFAKNKSEVIESMDFFVFCNS--FGISSSKLYIKKMIHLIWVKGTSDEGNNIQNHVLSCYKTLFFEPPPNSGTNEAANYIARNLISLTYDASLAELTSLEQMLCILMKDGYFSHLVITKLWQVYSYQKKDISRTQRRGSIIVIGMLALGNTDVVMQGLDHLIQIGLGPPGLE--DLVLARYTCIAIK---RIGKDASGSSNINFPNSHTLCQKLCMLLLRPSFSEE----WFGLEEQAIEAIYAVAKHPDELCTNIILLLTKQLFKPSNHENTTSNDDHAMDEDLDDSPEEETLKDEEEIGIRLAHLIFLVGHVAIKQLVYIEYC-EAEFKRRKADAE-----------------RLAVQNSNNPINGQETSEYDLITGTSEDDFSEAMTFIRERELLYGENSLLSRFAPLVVELCSNHKSHNNQSLLLAASLTLSKFMCLSNNFCMEHLPLLITILEKCDNPIIRNNLVIGLADLTVCFNHFIDEISEYLYRRLMDEESSVKKTCFMTLAFLILAGQIKVKGQLGIMARSLEDEDARISDLARMFFTDFAAKDNSVYNNFIDIFSVLSRSAEEQDEDDAKFKRIIRFLTSFIEKERHTKQLAERLAARLDRCKTQRQWDHVVYALSLLP 1142          

Query:  540 EIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCA--YNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNS----LIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQY--DTAKAAVEEMENQIGAMPAESVADVEKHIELLKEKVHGDEGT----IEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDC---------GVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNV-DAGIRKMLPHICSKDD-----SIRAAITNAYRILYLEIEDG--EHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKH------------------SAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWIT-----------MANETINTIYLLAESPNXXXXXXXXXXXXXXF----EWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRAL 3482
            ++E  +  I++L +  +++ +     +D F+ L T   + LLE     K + L+  + +IL + +KN+   +S    L+  L  + H+      + +      N+P    DIL E+    +N+    +D+    + S+FL +L++  P  ++  +  +   L+    ++R  V+   G IV ++ +++ +   ++      LIE++E+   DSN +VR+KA+     I   C +     K   K       ++ D SS+ R+N++++++ ++     K +  +QL+     +  K +  ++ + +  + ++   +      L++E+V  DEG     +E +  +S  ++R   E++   + N  ++ +  + I +  D           ++ I ++L S+  ++VLE++ F V A + +  + + GI+KML  +  K       SI   +   Y+ L+L   D     ++   I  +L  L +  +  +   ++ L+    E   +DQ VI  +W  + YN+   + +QK+                   S I+  M++        K    L+N G+   G +  DL L  Y C+A++  V              PK  T+  + +N  +   + K +LY I            M  + ++ ++ ++  P+IL++ LI   +   F    E +S+ S    +        L++ + + G +A+K  ++ +     E K+R    E ++   K +    D    T TT  +G    ++EL ++G T +D   + I+ + E  L+     +L +   IV  I  N+S+F D  LQ+ A+L L K+M +SSK C  ++ LL  +  +SP  ++R+N ++ LGD+   F   ++  T  LY RL D + +V+   L  ++ LIL   +KVKGQL EM  C+ + +  I  + ++FF ELA+KD A+YN   DI S LSS +  + ++ F+ I+++L+ FI K+   + L EK+  RL+    ++ W D++F L+ +P+ +  + AL
Sbjct:  163 QMENLLESITKLLEINLSKIFQTTPEKDLFIGLFTRPLFVLLEIEPVTKVSSLKMFIQRILAMCVKNHGQSSSIQSSLMTNLTYFLHLSVFNAELLKLLNDEYNYPQLTEDILKEISTRVFNA----KDTTGPKAISNFLIKLSELSPGIMLRQMNLVITLLNNSSITLRCSVVEACGNIVAEL-AQDPQTMEHYKQQIAVLIELLEERFQDSNPYVRTKAIQGCSKI---CDLSSKFNKSKAKFTSLAVRSLQDRSSLVRRNSVKLLSKLLLKHPFKAIHGSQLRLSEWEEYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEGSFNKSAELSRIENEVENINATNTSVLMKLKLMIVYYKDAISFIKEIHKSIELISNLLFSKNRNEVLESMDFLVLADAFDIELSEFGIKKMLHLVWMKGTNDEGTSISVHLIECYKQLFLTAPDSCNMQEKAAHIAKNLINLSIGASIADLASLEQLLGMMYEQKLIDQHVINILW--AIYNSASKASMQKEQNVNNRDSEKGFSKEQIHGSIIILGMLSLADNEIALKGLESLLNIGLGAVGLK--DLTLCRYSCLALERMV--------------PKRSTIITKAINQELEDVAVK-KLYAIIINYTKDNEYYPMCEQALSALFTISSKPDILATDLIREKTMMTFGKPEEEDSILSLEQSSRV----VSLSQLLFIVGQVAIKTLVYLE-KCEAEFKKRKIEAETRN--GKVKNQGADV---TNTTQDNGG---DKELEMIGGTNEDDFTDAIQFVKENELLFGEKSILGKFCPIVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKSLPLLITVMEKSPDPTIRSNAVLGLGDMAVCFNNLVDENTDYLYRRLHDENLMVQRTCLMTVTFLILAGQVKVKGQLGEMAKCLDNPDQGISDMCRLFFTELASKDNAIYNGFIDIFSNLSSDDL-LGKESFKKIIKFLLTFIDKERHQKQLNEKLVGRLRKCETQKQWDDIAFVLNNLPYKNEDVTAL 1164          

Query:   72 MEEFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHAS-----RDDQCKYRNCLKMNIYLLCQMIELFENEM-------------RQLQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDE----NSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGL---------DVQKGVPYAQLKTQ--------YDTAKAAV------------------------------EEMENQIGAMPAESVAD---------VEKHIELLKEKVH-----GDEGTIEVA----PLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNF-NVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEIE--------DGEHDRNQL--IIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNR----SRYNNNKYSILQKKHSA-----ILFSMVANVPKPFMSKYFNLLINEGIPTS-GFEKLDLQLIGYYCIAIQNFVKARK--------------SEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXF-----------------EWNSLKSGSDQNHWDCNQ---------------------FMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKK----TRKLAKDKRRQTATTDKD--------------GTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKD--NDGEGPSENIVNKSIRKNK 3803
            M EF+IP+ R DL   T ++ Y V++LV++ +L   +         +G+T ++       S+   W      I           C+ SV ++  ++    S     R+D  + RN +KM+ YLLCQ+IE+ EN+              R     L+   + ++      ++  +E   AI  + QL +  I QFWDPPVVEDDFVNL+ N+CYKLLEN     NA LR A++ +L  +I+ Y HG +  +KL Q+L  + H    L  I  NF+  E     V+++L E+C+YN  DLERDS  + +  SFL  ++   P     ILP ++ +L EDPY MRNC L V+GE++  +++ + +    +    + L++V+++H+ D NGFVR++AL I  ++    G+P     +L  LLVG +GA+ D SS ARK A+R++T I+           D+ + +   QL+ Q        ++   AA                               EE++ +     AE+ A+         V +    L+  +H       EG + V     P  S  VA E     L + +  +    ++   A  +  G++++ ++L S+  +DVLEAI FF+ AK +   ++DA +R M+  I S+++ IR A+ +A R LY + +        DG      L  +I +L +LV   T G+F  ++ ++    + G +D+ +   +W+R    +    +  ++  ++        IL  M+++  +  +  + N L+  G+ T+ G+  +DL+   Y C+AIQ  +   K              + K  EPFRLP +  L   L  L ISTF+  SR++WI +  + + TI+ L ++P+++ +++I  + ++L                  E +    G ++N    ++                     F+L +FI +AGH+A+K  +H + S+L ELKRR  + EE  Q KK    T + A+       +T  D              G   +EEE  L+GA ADD EA++IR +    ++ +   LL+RLL +VV +C + S++ D DLQ  ASLSL K ML+SS VC  N+ LLF LA RSP E +RANLIV LGDL +RF   +EP+TPNLY+RLRD SP VR+N LN LSHLILNDM+KVKGQ+SEMT C++DEN R++ LS++FF+ELA K  ALYNV+PDIISRLS  E GV E KFR+ +++L P I+K+   E L EKI +R + +  ER WRDL++CL +M FN+ M+R LQ NL  FA +L + +V  + + I+ N KKN+K + L  +EE    I +   KGV DEEA    QR  +   +   K R  A     K      +  S  IV   I +++
Sbjct:    1 MLEFVIPVSRSDLLNSTISS-YSVNELVSVRNLASAV---------KGNTDVW-------SLRLAWGESVSNIG----------CEVSVRELVGVIRPLGSTSGLDRNDFLERRNAIKMHTYLLCQLIEIIENDSTAETSASASVKIGRGRNKALNSAAKVRRPEFDMSLNWPDECSSAITVLDQLCKLDIKQFWDPPVVEDDFVNLLANSCYKLLENKTLSANATLRTAITNLLSTLIQFYKHGIACCLKLAQMLQCFAHTTNVLSAIVNNFMTEETMVPFVKELLNEICSYNGEDLERDSTGTHNLCSFLELVSSAHPPLATSILPLIRARLSEDPYQMRNCALNVIGEVLRNLHADHAQIEGKDKIQRDRLMDVLQEHIHDVNGFVRARALQIWCNLASAGGLPIRRQVQLAGLLVGPEGAVFDVSSFARKYAMRLLTIIITQCPAAKLSMEDLARVLNKEQLRLQVLEENFGRFNQEDAATIPSNPDDGNDAKKNLSQDHEEEGREDEGNGEEIDREEECQGAEAQAEEEDVVAEQGVSEAAAALEAVIHSAAQVAQEGQMNVTSSQPPPISAEVAFEAQRADLVRQRACVAYLREMQRFATYVSTGIENVCNLLHSKNVTDVLEAIEFFLTAKQAGVRSLDAALRHMMAMIWSQEEQIRKAVLDASRRLYFQPDIVNESFTVDGRLSSAALATVISTLVRLVSESTMGDFVSLERILRELLDLGHVDEDLKRELWSRFTDLAATMTDTAAVRSERRQELKALLILLKMISSPSRRNLELHLNDLVKYGLGTATGYANIDLECAMYVCMAIQQMIPTDKVGKQKSHSTRSTPANSKYHEPFRLPVSDQLCISLRRLLISTFTSSSRIHWIPLMEQAVATIFQLIDTPSLVMAEVIREIGEQLLRTLTKPPSSTQPQKEVQEPSQFGEGGEENTHAQSEVDAASDNAELVSQAVSPTVPSFILARFIALAGHVALKMLVHLEFSVLNELKRREVIQEESKQAKKHSLKTPRSARLNANPNTSTLVDITNGTQKGEMSGVVGNSALEEEAALLGAVADDAEADYIRNVLNSEIVLESDHLLSRLLPLVVHVCSHPSRYVDPDLQASASLSLAKFMLVSSVVCEQNLQLLFTLAERSPFEVVRANLIVGLGDLARRFPNLIEPWTPNLYARLRDTSPKVRINALNTLSHLILNDMVKVKGQISEMTVCLVDENDRLRQLSRLFFRELAQKGNALYNVIPDIISRLSDPEVGVDETKFRSTVDFLFPLIEKERLCETLVEKICSRFRVTQTERQWRDLAYCLRVMSFNERMIRTLQENLPIFAQQLFIPDVYQSFSEILANVKKNSKADALPHLEEFEAKIEEFHRKGVADEEA---LQRAEVMAKKAVTKRRRIAAPDARKSMRRANQASSSGIVTGGIERSE 1394          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHASRDDQ----CK-YRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLR---EALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANF---NSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRI-ITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEMENQIGAMPAESVADV---------------------------EKHIELLKEKVHGDEGTIEVAPLESQGVAR--------EMLEMKLTQSKNVLLVFEQLMEIAFLID---------CGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNV-DA--GIRKMLPHICSKDDSIRAAITNAYRILYLEIE-DGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAE-PFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGS--DQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRK---LAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKN-AKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSDASIDDNQ 3854
            EF+I   +EDL   +S NQY V +  +   LP  +      F  +G  +I   FD L+S +  +  + +  +  +W    K   +S+P++   +N H + DD     CK      KM +YLLC  ++ +E     +     K  RKKKK V    DL  E   AI  +  L Q  I + W PPVVE +FVNL++N CYK+LENP    + +L+   E++ +++  ++K YNHG    +K++QLL  + H+    V+     +        V +++ E+   +  DL RD+ +S ++++FL+ELA+  P   IP +  L   L+E+ ++MRN  L++  EIV+Q  S  D +       + L++ + +HL D + FVRSK L +   +  K  +P  L  ++L +  G    ++D +   RKNA+++ I  + G    + +P  +L  + ++ +A ++EM    G  P     D                            E+ I++   ++  +E   ++     + VAR        E  + +  Q +    + +Q M + FL D           +  +  +L S+  SD+LEAI FFV A    F+V DA  G+R+ML  I S ++ ++ A+ NAY+ LY+ +E  G   R   ++ +LS L+   T GE   ++ L+    +SGDL +  I+ +W +        +  + + + +L +MVA+     ++   N+L++ G+   G +  D +L    C A+      + +    E P R P T+ +F+    L +   +    +++   A  +++ IY LAE P+++   ++  +   +++ +  +SG+  +    +    +LT+   VAG +A++Q +H DV +  EL+RR  V EEK +    +K   L    RR+ +T  +       E+  LVGA ADD EAE++RK+CE  ++T    LL+ +  +V+ +  N +K+ D  L+  ASL L + ML+S + C  ++ LLF +  +SP E +R+NL++ +GDL  RF   +EP+TPNLYSRLRD SP+V+   LNVLSHLILNDM+KVKGQ+S++  C+ID ++RI  +S++FF E A K  ALYNVMPDIISRL   E  V+E+ FR +++ ++  IQK  Q E+L EKI  RL AS  ER  RDL +CLSL+ FN+  LR +  + N  + K+H + V + +  I+   KK  AK EI  +I+E+   I +  D   ++++    AQ   + K +  K                        NK  RK +AK +  E+ + S+DD++
Sbjct:    5 EFVISENKEDLLHSSSPNQYVVEQTYSKHELPGKLRDAYVSFSRQGTVYILTHFDTLFSALVKFDELALSQQNDAW----KVVSQSIPQLISDVNKHLNSDDNNPETCKELVTITKMIVYLLCLFLQNYETRSLVVPGSDAKSGRKKKKPVDDGFDLEAERNFAITSLDHLIQLPIHKLWSPPVVEQEFVNLVSNACYKILENPSIS-HVRLKGTVESVFRVIGALVKRYNHGLGFQLKIIQLLQHFEHVAPACVHGLVTMIELFGCSQMVVELVREIGKVDPHDLARDTSSSRNYAAFLSELAERVPSAFIPCISLLSVHLEEESFTMRNSALSIFAEIVMQELSGEDLDERKRELRDQLLDPLLEHLHDVHSFVRSKTLQLWHKLSLKHAIPLNLQHKVLTMTTGR---LNDKTGTVRKNAVQLLIVLMQGNPYGERLPLEELGAKKESEEAKLKEMLEVSGNQPQRIQVDPSKCGPTKTELWNAMEPEILVAIHEVFDEEDIDMSMSELTNEEVIQQLNACNYKRVARMFITEDDEEQEDPQPPQEEESKEIGQQRMLVMFLKDSHAFASSVYAAIPMVCQLLCSKQTSDILEAIDFFVTA--FEFDVLDAMQGVRRMLSLIWSSEEDVKKAVVNAYKRLYMNMEATGSKRRALQVVSNLSALISLSTQGELASLEELIAMCVKSGDLPKICIQVMWEKFSMALPDTTEEESRSALMLLTMVASAEVQVVTSNVNVLVSVGLGERGSK--DFRLAHLTCAALLKMAPTKAATDCKEQPMRFPPTNEIFECSKKLLVEGLTRLEDVHYSQFATTSVSLIYTLAEHPDMIMGDVLKEMCAIVYKSSRDQSGNLMENAELEVPTTVLTRIFVVAGQVALRQLIHLDVHVYSELRRRARVREEKQEETSKQKRNLLQSASRRRVSTRPQQEQCESGEDDELVGAVADDDEAEYVRKICESEIVTGGHSLLSSMAPLVILVNSNPAKYPDPSLRAAASLCLAEFMLVSPQFCSQHLRLLFTVLEKSPEEVIRSNLVIAMGDLNFRFPNLIEPWTPNLYSRLRDDSPIVKRTTLNVLSHLILNDMVKVKGQISDIALCVIDPDTRISSMSRMFFSEFARKGNALYNVMPDIISRLCDPEAAVAEENFRVVLKGIIVLIQKDKQNESLVEKIILRLGASRTERQSRDLMYCLSLLSFNERSLRRILEHWNCISDKIHEEGVVETLNAILTTTKKAFAKQEIRGLIDEIEAKIQETVDADQDEQQVVRKAQATQVTKAQAPK------------------------NKPKRKQRAKDLDSEE-EVSMDDDE 1293          

Query:   75 EEFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFEN-EMRQLQSVLDXXXXXXXXTVATKMDLFE---EIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNS---LIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEMENQIGAMPA-ESVADVEKHIELLKEKVHGDEGTIEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA-GIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDR--NQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQN-HWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGL---VGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQAS-NDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEA---NSSAQRVNIKKGRKTKKARETAIVTKHKDNDGE----GPSENIVN 3782
            E F +P+  EDL   +  N Y V ++     +  +I     + R+ G   I  +F+  YSV+   + +D+ IK+  W  LL   ++    +  +L  +   +D+ K    LKM  Y+L  +IE+FEN E + L  ++   K +K     T    +    E + A+N I QL Q +I++ WDPPVVE+++V LI+N CY +LE  +  K    ++ +  I+ ++IK YNH   + VK+VQL+  + H+ T +      ++      +   DI+ E+   +  +L RDS ++  ++ FL ELA++ P  +   +  L   LD + Y MRN VL+ +G IV+ +  K+D + +   S    ++ +E H+ D N FVRSK + I   +I +  +P      L++L++     + D SS  R+NA++ +   +  +     PY      +D  K A+  +EN    +   ES  D EK +  ++++ H  +       L S+    E +E K+ Q K V    +  +     +   +  I  +L S+ PSDVLEA+ FFV A+S  FNV   GIRKMLP + S++ +++  +  AY+ LYLE   G++ +  ++ I+  L  LV   T GE T V+ LV  F   G + +  I  +W       N  +     ++ ++  M+A   K F++   + L++ G+   G +  +L L    C  +Q   + +K  K+A   RLP+ H +F+R+  +     +     +W+  + E +  +Y LA SP  +  +++ S+ K+L     +  GS ++ H + +  +L++FI   G +A+ Q +H DV+I +ELK R    ++ ++    R ++ +K++  +++D+D       +LGL   VGA ADD E E IR+LC+  ++T  + +L    N +V +C N+ KF ++ LQ  A+++L K ML+SSK C  ++ LLF +  +S   S+RANL V L DL  RF   +EP+T +LYS+L+D S  V+ N + VL+HLILNDMIKVKGQ+SEM  C+ D N  I +L+K+FF EL+ K  A+YN++PDIISRLS  E GV+E  FR+I++Y+M FI+K  Q ENL EK+  R +A+  D+R WR+L++CLSL+  ND   R L  N + F   L  D+V+ +   ++N  K+ AK E  A+ EE    + + R+KG+E++ A    +SA++   K   K K  ++   ++  +D+D E     P E  VN
Sbjct:   93 EYFKLPLKMEDLLHVSEINSYVVEEVATTREIQCNIGSANSNLRKHGADQILNVFNLYYSVLTKHNELDVMIKQDVWTTLLSVMKEYASDLTVMLEKN-DINDKKKELKILKMLSYVLVNLIEIFENSESKSLPDLVTPRKSRKGTKKKTTTLSWSWKNERDAALNVIMQLLQTEISRLWDPPVVEEEYVTLISNCCYTILEKQESAKVNSTKDIIFHIIGILIKKYNHSLGASVKVVQLIQHFEHLATVMADAVAFYVNEYQANTVASDIIREIARISPQELSRDSSSTRGYAVFLAELAEKIPFVISANISLLISHLDGESYVMRNAVLSTMGAIVVSLLRKDDLDESAKKSRDHFLDRLEAHVHDVNAFVRSKVIQICTYVIGEKAVPIARQPGLVELILDR---LHDKSSNVRRNAVKFLASYMARN-----PYG---ADFDVEKLALT-LENTNSTIKQLESTLDQEKPVVKVEDQDHDSQNH-----LSSEETMNE-IEQKILQHKLVARYLQDSIGFVKQVQNAIPIISGLLGSKTPSDVLEAVDFFVTARSFGFNVSQNGIRKMLPLVWSREQAVKEGVIEAYKKLYLENTVGQNRKKDHKAIVQGLLSLVKGSTIGELTSVEELVREFMRKGLILKETIRLLWGYFIMAVNDVTQEDSHYALVILGMIAEEEKSFLANNISALVDTGLGLRGED--NLVLAKDTCHVLQKLYRRKKEIKIA---RLPEDHMIFERITTILCKGITNLKCKFWVPFSEEAVKLVYNLALSPEEVCKRIMQSIVKQLMP--DINEGSTEDGHNEISPRLLSRFISYTGDVALCQLVHLDVTISKELKERRLAEDKAEE--NNRTISGNKKKINSSSDED-------DLGLGGCVGAAADDAEMELIRQLCDSNVVTG-NGMLAVCANFIVAVCGNSKKFNERGLQNAAAVALAKCMLVSSKFCEQHLQLLFTIVEKSQFPSVRANLAVALHDLTVRFPNLIEPWTGHLYSQLKDSSLEVKRNSIKVLTHLILNDMIKVKGQISEMAVCLEDSNKEISNLAKLFFSELSKKGNAVYNILPDIISRLSDVEVGVNEACFRSILKYVMSFIEKDRQCENLTEKLCYRFRAAKTDDRQWRNLAYCLSLLNLNDRAFRKLYENFSCFQHALVDDDVDSSFNTVLNKMKRFAKPETKALAEEFQDRLNESRNKGIENDVAAQRAASAKKTPRKSVSKRKNRKKPVNLSFEEDSDVELFDIDPDEVSVN 1315          

Query:   81 FIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQK---SVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQ--LQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDF--CKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKN---DENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIV--------------------GLDVQKG-----VPYAQLKTQYDTAKAAVEEMENQIGAMPAES--------------VADVEKHIELLKEKVHGDEGTIEV----APL----ESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDR--NQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSE--KLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVED 3650
            F IP+   DL K     QY V +++ +  L       +  FR  G   I + FD LYS+++H+ ++D  IKE+  +L++K   +    +P I E LN  A +  +  + N LKMN ++L Q++E FE E  +  L +V   GK KK K+ +       E E  +  ++ L Q +I + W   VVE++FV+++T  CYK++ENP+    KN   REAL  +L V +K YNH  S+ VK++QLL  + H+P+ LV+    +         + +I+ E+    S DL R+S    +F++FLTELA+  P  ++P +  L D LD + Y MRN VLTV+GE+V++V S +   +   +  +  ++ +++H+ D N +VR   L I   ++++  +P    + ++ L+VG    + D S    KNAI+++   +                    G  V +      VP A + +  +  +A + E++     +  ES               ++V   + L+  K  G E         AP+    + +  + E+ +  L + + ++         A  I+  +  I  M+     S V E I FFV    S F V     G+R+MLP + SK+  +R A+ +AYR LYL   +GE +R   Q ++ +LS L+V+ + G   C++ +V  F + GD+   VI+ +W +     +  S L+++ + +L  M+       +    + L+  G+     E  D QL    C  I     ++K    K  EPFRLPK H+LF  L      T +    L+W+      +  +Y L E P  + S+++   S      +  +    +       ++LT  + +AG +A++Q +H + ++  EL+RR  + EE++                   +K     +EEELGLVGA+ADD+EAE IRK+C+  L+ +  + L+  L +++ IC N  ++ D DL  +A+L+L K M+ISS  C  ++ LLF L  +SP  S+R+N+++ LGDL  RF   +EP+TPNLY+RLRDPS  VR     V++HLIL DM+KVKGQ+SEM   +I+ +  I  L++ FF EL+NK  A+YN++PDIISRLS  + GV E+ F+TIM+ L+ +I K  QTE+L EK+  R + +  ER WRDL+ CL+L+PF++  LR +Q   + +  KL  D V ++    +   ++ AK E+ A+I+E    + +  +KG+E+
Sbjct:    9 FHIPLAFRDLLKSGGIGQYVVQEVLPVRQLDAQFDAFQSSFRTEGPLCILQHFDTLYSILHHFRSLDTAIKERVLELMVKVASRHASELPAILEDLNLSAPQ--RAAHLNALKMNCFILTQLVEAFEAETYKASLGNVEPSGKGKKAKSKSEGFSWEAERESILQALTHLLQLEIRRLWSMSVVEEEFVSMVTGCCYKMMENPNIVAAKNKSTREALGHLLGVTVKRYNHMLSASVKVIQLLQHFEHLPSVLVHAVSLWATEYGMKPVIGEIMREIGQKCSQDLSRESSGFKAFATFLTELAERIPAIMMPSISVLLDYLDGENYMMRNAVLTVMGEMVLRVLSGDQLEEAEKSTRDQFLDTLQEHIHDVNTYVRCCVLQIYNRVVQEKALPLTRFQSVVTLVVGR---LFDKSVNVCKNAIQLLASFLANNPFTCKVSLLLKMAFCPFGFLVARFQCIYFVPAAVVISPEEEWEAMLPEVQEAFNVVQQESKEEADDDAQDEKCHPSEVLSSLVLIAGKEAGSEQPATTDQDDAPVKPTSDEEQPSAEVQQSDLGKQEMLVQYLSDAHHFAVKIEEAIDVISKMMYETAVSVVQEVIEFFVTV--SQFGVSQALLGVRRMLPLVWSKEPGVREAVLSAYRRLYL-TSNGESERVKAQALVRNLSLLMVDSSAGILQCLEEIVSEFIQKGDIHPTVIQLLWEKFT-QKSPSSALERRAAIMLLGMMTKGQPEIVMSNLDTLVTVGLGEQVQE--DYQLAQEVCNCILKITDSQKPSLGKSTEPFRLPKDHSLFVHL------TEAVAGGLHWLPFKETAVRLVYELGEEPEEICSEILLRCS------HKAEKREPERTPTLPAYLLTHLLSLAGDVALQQVVHLERAVSSELRRRRVLKEEQE------------------AEKANESTMEEELGLVGASADDIEAELIRKICDTELLGE-QQYLSAFLPLILRICNNPGRYNDPDLCTVATLALAKFMMISSDFCDTHLRLLFTLLEKSPLPSVRSNIMIALGDLSIRFPNLIEPWTPNLYARLRDPSREVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIESDQEIAALARNFFNELSNKGNAVYNLLPDIISRLSDPDCGVEEEAFQTIMKQLLSYITKDKQTESLVEKMCHRFRTARTERQWRDLAHCLALLPFSEKGLRKMQDCFDCYGDKLSDDAVYNSFLSTVAKMRRGAKPELKALIDEFEQKLNRCHNKGLEN 1220          

Query:   72 MEEFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILN-SHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSV-LDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFC--KNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNS---LIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRII---------------THIVGLDVQKGVPYAQLKTQYDTAKA-AVEEMENQIGAMPAESVADVEKHI------ELLKEKVHGDEGTIEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLT--SRVPSDVLEAIFFFVAAKSSNFNVDA---GIRKMLPHICSKDDSIRAAITNAYRILYLEIE-DGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKL--DLQLIGYYCIAIQNFVKARKSE--KLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQ----FMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGV----EDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGP-----SENIVNKSIRKNKAK--------RIHEEDSDASIDDNQSI--------ASSRQRR 3881
            M EF +P+  E+L K    NQY V +++++  LP  +   +  FR +G   + E FD +YS+++H+ ++D  +KE + + L+K   +   ++  IL+ +  S  D+  + N LKMN Y L +++E FE     L  + L    +K +   A   D  EE +  +  ++QL Q  I   W   ++E++FV+L+T  CY+LLENP     KN   R+A++ +L V +  YNH  S+ VK++Q+L  + H+   LV     +       S V +I+ E+      +L RD   +  F++FLTELA+  P  L+  +  L D LD + Y MRN VL  + E+V+QV + +   +A  ++    ++ ++ H  D N FVRS+ L +   I+++  +P    + ++ L VG    ++D S +  KNAI+++               T + G   ++     +++ Q  TA A AV + E +  AM  E  + +++ +      E + E++   E T EV     Q +A+   +  ++ ++     F++    +  ID    +   +L     +   V E I FFV      F V     G+R+MLP I SK+  +R A+ +A+R LYL  + D    + Q +I +LS L+V+ + G   C++ ++  F  + +L  AV + +W R+         L++  S +L  M+A      +    + L+  G+     EKL  D +L    C AI N    RK    K   PFRLP+ H LF+RL       F     L WI      +  IY LAE P ++ ++++   +K+  E    K  S ++  +       F+L   + +AG +A++Q +H + ++  EL RR  + EE++   K     K+K   + TT       +EEELGL GATADD EAE IR +CE  L+ D  + L   + +++ +C N   + + DL   ASL+LGK  +IS+  C   + LLF +  +SP   +R+NL+V  GDL  RF   ++P+TP+LY+RLRDP+  VR     V++HLIL DM+KVKGQ+SEM   +ID   +I  L+K FF EL++K  A+YN++PDIISRLS  E GV E+ F TIM+ L+ +I K  QTE+L EK+  R + +  ER  RDL++C+S +P  +  LR +  N + F  KL  + +  A   ++   ++ AK E  AVI+E    +     +G+    E E   + +QR    K + +  +R   + +   DND   P     +    N   R +K K           EED  A + ++++         AS+R+RR
Sbjct:    5 MYEFHLPLSPEELLKSGGVNQYVVQEVLSIRHLPPQLRAFQAAFRAQGPLAMLEHFDTIYSILHHFRSIDPGLKEDTLEFLIKVVSRHSQELPAILDDTTLSESDRNAHLNALKMNCYALIRLLESFETSQTNLVDLDLGGKGKKTRTKAAHGFDWEEERQPILQLLTQLLQLDIRHLWKHSIIEEEFVSLVTGCCYRLLENPTISHQKNRPTRDAITHLLGVALTRYNHMLSATVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGFAAFLTELAERVPAILMSSMCILLDHLDGENYVMRNAVLAAMAEMVLQVLNGDQLEAAARDTRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGR---LADKSVLVCKNAIQLLASFLANNPFSCKLSDTDLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWEAMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEEVKGRIHQLLAKASYKQAISLTREATGHFQESEPFSH-IDPEESEETRLLNILGLIFKVVQEVIEFFVMV--FQFGVPQALFGVRRMLPLIWSKEPGVREAVLHAFRQLYLNPKGDSARAKAQALIQNLSLLLVDASVGTIQCLEEILCEFVRNDELKPAVTQLLWERA-TEKVACCPLERCSSVMLLGMMARGKPEIVGSNLDTLVGIGLD----EKLPQDYRLAQQVCHAIANISDRRKPSLGKRHPPFRLPQEHRLFERLRETVTKGFVHPDPL-WIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEKLEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQEHKTKD---PKEKNTSSETT-------MEEELGLAGATADDTEAELIRGICEMELL-DGKQTLAAFVPLLLKVCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPEPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIFSAFLSVVGKLRRWAKPESKAVIDEFEQKLRACHTRGLDGIDELEIGQTGSQRAPSAK-KPSTVSRHQPLASIVSDNDFVTPEPRRTTRRHPNTQQRASKKKPKVVFSSDESSEEDLSAEMTEDETPKKTTPILRASARKRR 1318          

Query: 1623 AFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVD---AGIRKMLPHICSKDDSIRAAITNAYRILYLEIE-DGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNF-TESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEW---------NSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRV-------NIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIH-----EEDSDASIDDNQ----SIASSRQRRT 3884
            A  ++  +  I +ML  +  + V EA+ F V A+   F+V     G+RKMLP + S D +++ A+  AYR LYL    D    + Q ++DSLS+L+V+ + G   C++ +V  F +    L  +V++ +W R      + S L ++ + +L  M A   +  +    + L +  +     E  D  L     I I N   + +  K A PFRLP  H LF   L   I+     S  YW T   + I  IY LAE+P+ L ++L+   ++ L E          + +  GS  +    N   L   + + G +A  Q  H + S+  EL+RR    EEK + K+     K+K    +         +E+ELGL GA+A+D EAEFIRK+CE  L+ D   +L+  L ++V +C +  ++    L   A L+L + M+IS  VC DNI LLF +  +SP   +RAN I+ LGDL  RF   LEP+TPNLY RL D +  VRL  + VL+ L+L D++KVKGQ+SE+   ++D    I  L+  FF EL+ KD A+YN++PDIISRLS  E G+ E+ F TIM+ L  +I K+ QTE+L EK+  R + +  ER W DL+  LSL+   +   + LQ   + ++ KL  D V   +  I+   ++ AK +  A +EE+   +  +  KG+E+ E   S Q++       N +  +  K  R+T    K K ++    S+ +  K  R    K ++     EED DA + DN+    +   +R RRT
Sbjct:  633 ALQVERAIAVINNMLYWKTTTVVQEAVQFCVTAR--EFSVADSVCGVRKMLPLVWSTDTAVKEAVIQAYRRLYLNPHGDNTRAKAQTLVDSLSELMVDASLGTIQCLEEIVQEFFSNESALQASVVQALWERFS-GKRETSALHRRAAVLLLGMAARAEREVVLSNLDTLCSVALGEKVTE--DYLLARDAVITIANITDSVRQNKGA-PFRLPVDHHLFS-CLTQAIADGVVLSDPYWQTFMEQAIRLIYFLAETPDQLCARLLQRSARLLLEQITEGGEPNQSEVSEGSQDSEQQVNCASLAHLLSMCGAVAFWQVSHLERSVSTELRRRRGEKEEK-EEKEKGPAGKNKEANDSC--------VEDELGLTGASAEDTEAEFIRKICETELLAD-GNMLSVFLPLLVKVCSSPGRYTHTQLTTAACLALSQYMMISPTVCKDNIRLLFTVLEKSPLPVVRANAIIALGDLTVRFPNILEPWTPNLYGRLCDENASVRLTSITVLTQLVLKDVMKVKGQVSEVAVLLLDSEPHIASLALNFFNELSAKDNAIYNLLPDIISRLSDPERGMKEEDFNTIMKQLFSYITKERQTESLVEKLCQRFRTAKTERQWADLAVSLSLLSMCERGFKKLQECWDCYSDKLTEDAVYQPLLSILAKLRRRAKPQFKAQVEELEKKMTAVHTKGLENVENEESEQQLDDQAPSQNSQTPQPPKSTRKTRGRVKSKMDE----SDLVTPKRTRARPKKVMNFSSDEEEDEDAVMADNETPKVTTPIARTRRT 1395          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHASRD-DQCKYRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATKMDLFE---EIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDF--CKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSK---NDENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVG 1340
            +FI+P+  +DL K  +  QY V  +++   LP H+   +   R +G   I E FD LYSV+ H  +VD+ +KE + + L++  +     +  +L S      D+ +  N +KM+++LLC++ E  ENE      V    K +KK+  +    L +   E E  +  ++QL Q  I   W+  +VE++FV+ +T  CYKLLENP     KN   R+A+  +L VM+K YNH   + VK++QLL  +  + +        +       + V +I+ E+   ++ +L R+     +FSSFL+EL+   PE +IP +  L   L+ +  SMR  V  VLGE++++V S    +D   A+ +  ++ +++H+ DS+  VR++ L +   I+    +P      +++L VG  G   D S    K+AI+++   + 
Sbjct:    4 DFIVPVSLDDLVKSGAIQQYVVQDVLSPKQLPSHLNNFKAALRSQGPLCILEHFDTLYSVLKHCRSVDVSLKEDTLEFLIQVVRGLSGSLPSLLLSGTLSAADRKQQLNAVKMSVFLLCKLTEHLENESCMESIVTAPSKGRKKEKASGGKGLIQWDSERETVLQCLTQLLQLDIRSLWNLSLVEEEFVSCVTCCCYKLLENPTIGHMKNKATRDAIIHVLGVMVKKYNHMLGACVKVIQLLQHFEQLSSVCAQAVSAWSSEYGVKTIVGEIMREIGQKSNDELAREGSGVKAFSSFLSELSSLIPEAMIPNISLLLTHLEGESSSMRVAVCEVLGEVLVRVLSGDKLDDSGRADRDRFLDTLQEHIHDSHSHVRARVLQVYTRIVNSKALPLCRYTEVMQLAVGRLG---DKSVHVCKSAIQLLAAFIA 430          

Query: 2808 VFICKNASKFKDQDLQKI----ASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQL-SEMTTCIIDENSRIKHLSKIFFQEL 3221
            + + +  S F    +  I    A ++LGK+ L +  +    I  L      SP  S+R N+I+ + DL  R+TT ++ Y   + + LRD  P +R   L +L++L+  D +K +G L     + ++D +  I+  ++     L
Sbjct:  923 ILLSQALSHFHGSSMPTIVRAHAFITLGKLCLQNEDLAKKCIPALARELEISPEISIRNNVIIIMCDLCIRYTTLVDRYISKISACLRDEEPFIRRQTLVLLTNLLQEDYVKWRGFLFHRFASVLVDSDPGIRSFAEFCLIHL 1065          

Query:  540 EIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCA--YNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNS----LIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQY--DTAKAAVEEMENQIGAMPAESVADVEKHIELLKEKVHGDEGT----IEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDC---------GVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNV-DAGIRKMLPHICSKDD-----SIRAAITNAYRILYLEIEDG--EHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKH------------------SAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWIT-----------MANETINTIYLLAESPNXXXXXXXXXXXXXXF----EWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRAL 3482
            ++E  +  I++L +  +++ +     +D F+ L T   + LLE     K + L+  + +IL + +KN+   +S    L+  L  + H+      + +      N+P    DIL E+    +N+    +D+    + S+FL +L++  P  ++  +  +   L+    ++R  V+   G IV ++ +++ +   ++      LIE++E+   DSN +VR+KA+     I   C +     K   K       ++ D SS+ R+N++++++ ++     K +  +QL+     +  K +  ++ + +  + ++   +      L++E+V  DEG     +E +  +S  ++R   E++   + N  ++ +  + I +  D           ++ I ++L S+  ++VLE++ F V A + +  + + GI+KML  +  K       SI   +   Y+ L+L   D     ++   I  +L  L +  +  +   ++ L+    E   +DQ VI  +W  + YN+   + +QK+                   S I+  M++        K    L+N G+   G +  DL L  Y C+A++  V              PK  T+  + +N  +   + K +LY I            M  + ++ ++ ++  P+IL++ LI   +   F    E +S+ S    +        L++ + + G +A+K  ++ +     E K+R    E ++   K +    D    T TT  +G    ++EL ++G T +D   + I+ + E  L+     +L +   IV  I  N+S+F D  LQ+ A+L L K+M +SSK C  ++ LL  +  +SP  ++R+N ++ LGD+   F   ++  T  LY RL D + +V+   L  ++ LIL   +KVKGQL EM  C+ + +  I  + ++FF ELA+KD A+YN   DI S LSS +  + ++ F+ I+++L+ FI K+   + L EK+  RL+    ++ W D++F L+ +P+ +  + AL
Sbjct:  163 QMENLLESITKLLEINLSKIFQTTPEKDLFIGLFTRPLFVLLEIEPVTKVSSLKMFIQRILAMCVKNHGQSSSIQSSLMTNLTYFLHLSVFNAELLKLLNDEYNYPQLTEDILKEISTRVFNA----KDTTGPKAISNFLIKLSELSPGIMLRQMNLVITLLNNSSITLRCSVVEACGNIVAEL-AQDPQTMEHYKQQIAVLIELLEERFQDSNPYVRTKAIQGCSKI---CDLSSKFNKSKAKFTSLAVRSLQDRSSLVRRNSVKLLSKLLLKHPFKAIHGSQLRLSEWEEYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEGSFNKSAELSRIENEVENINATNTSVLMKLKLMIVYYKDAISFIKEIHKSIELISNLLFSKNRNEVLESMDFLVLADAFDIELSEFGIKKMLHLVWMKGTNDEGTSISVHLIECYKQLFLTAPDSCNMQEKAAHIAKNLINLSIGASIADLASLEQLLGMMYEQKLIDQHVINILW--AIYNSASKASMQKEQNVNNRDSEKGFSKEQIHGSIIILGMLSLADNEIALKGLESLLNIGLGAVGLK--DLTLCRYSCLALERMV--------------PKRSTIITKAINQELEDVAVK-KLYAIIINYTKDNEYYPMCEQALSALFTISSKPDILATDLIREKTMMTFGKPEEEDSILSLEQSSRV----VSLSQLLFIVGQVAIKTLVYLE-KCEAEFKKRKIEAETRN--GKVKNQGADV---TNTTQDNGG---DKELEMIGGTNEDDFTDAIQFVKENELLFGEKSILGKFCPIVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKSLPLLITVMEKSPDPTIRSNAVLGLGDMAVCFNNLVDENTDYLYRRLHDENLMVQRTCLMTVTFLILAGQVKVKGQLGEMAKCLDNPDQGISDMCRLFFTELASKDNAIYNGFIDIFSNLSSDDL-LGKESFKKIIKFLLTFIDKERHQKQLNEKLVGRLRKCETQKQWDDIAFVLNNLPYKNEDVTAL 1164          

Query: 1602 FEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNF-NVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEI-EDGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVN--FTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSA-ILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVK-ARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSDASID 3845
            F+  ME A  + C       +L S+  +DV EAI F V A      N   G+R+ML  I S+D +++ A+  AY+ LYL+        +  LI  +L+ L    + G+ T ++ LV      ++  +  AV++ +W R  +     +   +   A IL  M+A      +    ++L++ G+      K D  L    C+ +   VK +RK     EPFR P TH +F+RL  L  +   G S  YW+ MA + IN IY L+E P+ +S  +I  L+        L SG   +   C   +L +F+ V GH+A++Q +H DV+IL E+KRR  + E       T K A  K   + TT     +  EEE+GL GATADD E E+IRK+CE  ++T    LL+ L  ++V +  N SKF D  LQ  A+L+L K ML+SS+ C  ++ LLF +  +SP  ++RAN IV +GDL  RF   +EP+T NLY+RLRD SP VR N + VL+HLILNDM+KVKG +SEM TC+ DEN RI  L+K+FF ELA K  A+YN++PDIISRLS  + G+ E+ FR I+ YL+ FIQK  Q+E+L EK+  R +A+  +R WRDLSFCLSL+ +N+  +R LQ N   F  KL  ++V+ +   II  AKK AK E+ A+++E+   I +   KG+EDEE    A + +     + KK+ ++   ++ +          I      K +     E D D S+D
Sbjct:  626 FQTEMERAVPVIC------QLLGSKTTTDVSEAIEFCVTAHEFGLRNAIVGVRRMLVLIWSRDAAVKEAVVEAYKGLYLDPPAQNARAKMSLIAKNLTSLTQGASVGDLTSLEELVSATILMKAKLIPAAVVKLLWER--FAMKVITTEDESRGALILLGMLAGAEVDIVRSNIDVLVSTGLGPRA--KDDFLLARDTCVTLLKLVKTSRKRGNDDEPFRFPATHDIFERLTELITT---GNSYWYWVPMAEQAINVIYALSEHPDAVSETIIRKLA------TCLSSGKLMS---CPSAVLARFLTVVGHVALRQLIHLDVTILREIKRRQGIQE-------TEKEAAAKNIASETT-----MAAEEEMGLTGATADDAEIEYIRKICELEIVTG-QNLLSLLRPLIVCVVSNPSKFTDPKLQAAAALALAKFMLVSSEFCEAHLQLLFTILEKSPEATIRANTIVAIGDLTFRFPNMIEPWTSNLYARLRDESPHVRKNTMMVLTHLILNDMVKVKGNISEMATCLEDENKRIADLAKLFFHELAKKGNAVYNILPDIISRLSDPDCGIEEEPFRNILRYLLSFIQKDRQSESLVEKLCHRFRATRSDRQWRDLSFCLSLLSYNERAIRKLQENFGCFHDKLSDEDVHHSFMTIIGKAKKFAKPEVKALVDELEQRIDECHVKGMEDEEGYERASKASGVAATRPKKSVDSEEESRPRSKRTPRNPPRIPKTKSSKRRPMPSFESDEDDSLD 1344          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEIL-NSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATK----MDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLL----HSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSA---NFNSLIEVIEDHLSDSNGFVRSKALGILLSII-EKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRII-THIVGLDVQKGVPYAQLKTQY--------DTAKAAVEEMENQIG-----------AMPAESVADVEKHIELLKEKVHGDEGTIEV-APLESQGVAREML 1562
            +F+IP+ ++DL    S   Y V ++++  SLP  +  C  D R  G   I   FD  +S+I H+++VD  ++E++W +LL    +    I  I+    A  + +  + N LKM  YLL QM E FE E  +  S +    R K      K     D  ++ E  +  +  L Q  + + WDPPVVE++FVNL+T  CYKLLENP   +N   ++ +  +L +++K YN+G  + +K+VQLL    H  PHM   +  I   F       S V +I+ E+   +  DL RD+  + +++ F+ +LA   P  ++  +  L   LD + YSMRN VL V+ EI+ +V S  D + +     +  ++ +E+H+ D N +VRSK L I L +  EKC +P    + LL++++G    + D SS  RK A++++ + +V       +P   L+ +         + A    +E   Q+            AM  E  A V++HI   +E +  D+G+IE    L S+G  ++ L
Sbjct:    4 DFVIPLSKDDLLSSESG-AYAVDEVISARSLPPKLADCYIDLRTDGPCSILRNFDVFFSLIRHFTDVDSSVREEAWQVLLNALSQLSSNIQPIIEQGDADTETRKTHLNTLKMICYLLTQMSESFEAEATKPTSQVTGKGRGKSAASKKKNSAGFDWEQQRERLVEMLGHLMQLDVNRLWDPPVVEEEFVNLMTGCCYKLLENPAVIRNKTTKDVVINLLGIVVKKYNNGLGASLKIVQLLQHFEHLVPHMAQAVDTIATEF----GVKSIVSEIIREIGRMDPKDLARDTSGTRAYADFIVDLASRVPTLVLQSISMLMCHLDGESYSMRNGVLGVMAEIITKVLSTQDLDESAKRTRDHFLDRLEEHIHDMNAYVRSKVLQIWLHLCSEKC-IPLPRQQHLLEMVIGR---LHDKSSSVRKYAVQLLKSFLVFNPFGANLPLDHLQQKLIQETEKLKEIAPHLTQEAAGQVPVVAGRPKDVWKAMEPEVRATVQEHIG-EQEIIDDDDGSIEFQGDLLSEGQHKKAL 522          

Query: 2862 ASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQL-SEMTTCIIDENSRIK 3191
            A ++LGK+ L + ++    I  L      S   ++R N++V + DL  R+T+ ++ Y PN+ + LRD +P+VR   L +L+HL+  D +K KG L     T ++DE+  I+
Sbjct:  283 AFVTLGKLCLQNERLAKQCIAALARELEMSEDAAIRNNIVVVMCDLCVRYTSLVDRYIPNIATCLRDKAPLVRRQTLTLLTHLLQEDYVKWKGSLFYHFITALVDEDVEIR 393          

Query:   78 EFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLK 320
            +F +P+C  DL K    NQY V  +V+   LP  +   +   R +G   I E FD  YSV+ H+++V++ +KE + +LL+K
Sbjct:    4 DFFVPVCVGDLVKTGGINQYVVQDVVSPKQLPLQLNKFKAALRSQGPLCILEYFDTGYSVLQHFNSVELAVKEDTLELLVK 84          

Query:   72 MEEFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEMENQIGAMPAESVADVEKHIELLKEKVHGDEGTIEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSDASIDDNQSIASSRQRRTCQTKIDKVKNIFXXXXXXXXXKDVTPKKRDNTKRNLLVDSDSESE 4019
            MEEFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIE                  KKKKTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQASSSFSSFLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFLLMKRLLKLLVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEMENQIGAMPAESVADVEKHIELLKEKVHGDEGTIEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNILSSKLISSLSKKLFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSDASIDDNQSIASSRQRRTCQTKIDKVKNIFSSDESEDEDKDVTPKKRDNTKRNLLVDSDSESE
Sbjct:    1 MEEFIIPICREDLSKRTSANQYYVSKLVNMDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIE------------------KKKKTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQASSSFSSFLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFLLMKRLLKLLVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEMENQIGAMPAESVADVEKHIELLKEKVHGDEGTIEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNILSSKLISSLSKKLFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSDASIDDNQSIASSRQRRTCQTKIDKVKNIFSSDESEDEDKDVTPKKRDNTKRNLLVDSDSESE 1298          

Query:  159 MDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIELFENEMRQLQSVLDXXXXXXXXTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQAXXXXXXXLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFXXXXXXXXXXVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEMENQIGAMPAESVADVEKHIELLKEKVHGDEGTIEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNXXXXXXXXXXXXXXFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSDASIDDNQSIASSRQRRTCQTKIDKVKNIFXXXXXXXXXKDVTPKKRDNTKRNLLVDSDSESE 4019
            MDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIE                  KKKKTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQASSSFSSFLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFLLMKRLLKLLVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEMENQIGAMPAESVADVEKHIELLKEKVHGDEGTIEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNILSSKLISSLSKKLFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSDASIDDNQSIASSRQRRTCQTKIDKVKNIFSSDESEDEDKDVTPKKRDNTKRNLLVDSDSESE
Sbjct:    1 MDSLPKHITVCEQDFRERGHTFIYEMFDYLYSVIYHWSNVDMKIKEKSWDLLLKCCQKSVPKIFEILNSHASRDDQCKYRNCLKMNIYLLCQMIE------------------KKKKTVATKMDLFEEIELAINGISQLFQCKITQFWDPPVVEDDFVNLITNTCYKLLENPDFCKNAKLREALSKILVVMIKNYNHGNSSPVKLVQLLHSYPHMPTCLVYICRNFLGTENFPSTVRDILTEVCAYNSVDLERDSQASSSFSSFLTELAQEFPETLIPILPSLKDKLDEDPYSMRNCVLTVLGEIVIQVYSKNDENSANFNSLIEVIEDHLSDSNGFVRSKALGILLSIIEKCGMPFLLMKRLLKLLVGEDGAISDTSSIARKNAIRIITHIVGLDVQKGVPYAQLKTQYDTAKAAVEEMENQIGAMPAESVADVEKHIELLKEKVHGDEGTIEVAPLESQGVAREMLEMKLTQSKNVLLVFEQLMEIAFLIDCGVKDIQSMLTSRVPSDVLEAIFFFVAAKSSNFNVDAGIRKMLPHICSKDDSIRAAITNAYRILYLEIEDGEHDRNQLIIDSLSKLVVNPTFGEFTCVKNLVVNFTESGDLDQAVIECIWNRSRYNNNKYSILQKKHSAILFSMVANVPKPFMSKYFNLLINEGIPTSGFEKLDLQLIGYYCIAIQNFVKARKSEKLAEPFRLPKTHTLFDRLLNLCISTFSGKSRLYWITMANETINTIYLLAESPNILSSKLISSLSKKLFEWNSLKSGSDQNHWDCNQFMLTKFIDVAGHIAMKQFLHFDVSILEELKRRNTVTEEKDQLKKTRKLAKDKRRQTATTDKDGTLNIEEELGLVGATADDVEAEFIRKLCEFGLITDPSKLLNRLLNIVVFICKNASKFKDQDLQKIASLSLGKMMLISSKVCMDNIDLLFNLAARSPSESLRANLIVPLGDLIKRFTTKLEPYTPNLYSRLRDPSPVVRLNVLNVLSHLILNDMIKVKGQLSEMTTCIIDENSRIKHLSKIFFQELANKDKALYNVMPDIISRLSSAETGVSEDKFRTIMEYLMPFIQKKNQTENLFEKISTRLQASNDERSWRDLSFCLSLMPFNDTMLRALQFNLNNFAGKLHVDEVNDAITGIINNAKKNAKGEILAVIEEMSVNIVKLRDKGVEDEEANSSAQRVNIKKGRKTKKARETAIVTKHKDNDGEGPSENIVNKSIRKNKAKRIHEEDSDASIDDNQSIASSRQRRTCQTKIDKVKNIFSSDESEDEDKDVTPKKRDNTKRNLLVDSDSESE 1269