INO80 complex subunit B
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30028761 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of INO80 complex subunit B vs. Ensembl Fly
Match: CG10395 (gene:FBgn0033019 transcript:FBtr0347210) HSP 1 Score: 47.7506 bits (112), Expect = 9.095e-6 Identity = 55/208 (26.44%), Postives = 92/208 (44.23%), Query Frame = 2 Query: 269 SSGEEEKKSEIVLEGEDEWSDKECRYLAQMNDPRFMTARQRSLLDKRSGGRESNLEEMNFIDQIPALSN--RSALRPTGKAGDHXXXXXXXXXXXXXXXXXKLLKVTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSYVAFSDPDLCPIWQPGKPVLPATVQ----------CSADGCTNSKRYSCARTGRPLCYRIECYR 856 +S EE++ + G+ + D+E L ++ DP+ MTARQR++ + R + E FI+++ AL + + +P H+ +K +++++Q + K+ RL K+ ++ SIR S Q+P P S + P P VQ C GC N K Y+C+ T PLC + CYR Sbjct: 77 TSSEEDRWLTAIETGKLDVVDEE---LKKIKDPKLMTARQRAIYE-----RTQDSEINGFIEELIALPSGYKEKEKPQTAEEIHKALLKSQKRKQQADERREKDKLKTMERLLKK-------QATNRDRISIRNKSLQQPSYPKITYISAVTGNYVIVPPGYEYPLKVQLPRTPPPSQVCFVSGCENRKTYNCSTTNVPLC-SLTCYR 268
BLAST of INO80 complex subunit B vs. Ensembl Fly
Match: CG10395 (gene:FBgn0033019 transcript:FBtr0347209) HSP 1 Score: 47.7506 bits (112), Expect = 9.095e-6 Identity = 55/208 (26.44%), Postives = 92/208 (44.23%), Query Frame = 2 Query: 269 SSGEEEKKSEIVLEGEDEWSDKECRYLAQMNDPRFMTARQRSLLDKRSGGRESNLEEMNFIDQIPALSN--RSALRPTGKAGDHXXXXXXXXXXXXXXXXXKLLKVTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSYVAFSDPDLCPIWQPGKPVLPATVQ----------CSADGCTNSKRYSCARTGRPLCYRIECYR 856 +S EE++ + G+ + D+E L ++ DP+ MTARQR++ + R + E FI+++ AL + + +P H+ +K +++++Q + K+ RL K+ ++ SIR S Q+P P S + P P VQ C GC N K Y+C+ T PLC + CYR Sbjct: 77 TSSEEDRWLTAIETGKLDVVDEE---LKKIKDPKLMTARQRAIYE-----RTQDSEINGFIEELIALPSGYKEKEKPQTAEEIHKALLKSQKRKQQADERREKDKLKTMERLLKK-------QATNRDRISIRNKSLQQPSYPKITYISAVTGNYVIVPPGYEYPLKVQLPRTPPPSQVCFVSGCENRKTYNCSTTNVPLC-SLTCYR 268
BLAST of INO80 complex subunit B vs. TrEMBL
Match: A0A2R5LEP8 (Putative ino80 complex subunit b OS=Ornithodoros turicata OX=34597 PE=4 SV=1) HSP 1 Score: 66.6254 bits (161), Expect = 1.417e-8 Identity = 59/181 (32.60%), Postives = 97/181 (53.59%), Query Frame = 2 Query: 317 DEWSDKECRYLAQMNDPRFMTARQRSLLDKRSGGRESNLEEMNFIDQIPALSNRSALRPTGKAGDHXXXXXXXXXXXXXXXXXKLLKVTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSYVAFSDPDLCPIWQPGKPVLPATVQCSADGCTNSKRYSCARTGRPLCYRIECYRS 859 DE D+ L +M DP MTARQR+LL+ ++ +E EE+ Q P +S R +A ++ +E+++++++ T+E+LLK + SRL R R++ + +D + ++ S P V+F P+ P PA C GC N +RYSC++TG PLC +ECY++ Sbjct: 113 DEVDDE----LRKMKDPTLMTARQRALLESKAQTKER--EEVPVAAQPPQMSEEMLQRRMQRAKKRKQQAEEKKEKDKKQTIERLLKKS-DSRL--RGRKMTRKSDTPRVS-LLQRTSGTLMSFPVGVSF------PLTSRTAPEYPAKKMCGIKGCPNPRRYSCSKTGLPLCS-LECYKT 276
BLAST of INO80 complex subunit B vs. TrEMBL
Match: A0A293LKQ1 (PAPA-1 domain-containing protein (Fragment) OS=Ornithodoros erraticus OX=265619 PE=4 SV=1) HSP 1 Score: 65.855 bits (159), Expect = 2.495e-8 Identity = 62/181 (34.25%), Postives = 95/181 (52.49%), Query Frame = 2 Query: 317 DEWSDKECRYLAQMNDPRFMTARQRSLLDKRSGGRESNLEEMNFIDQIPALSNRSALRPTGKAGDHXXXXXXXXXXXXXXXXXKLLKVTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSYVAFSDPDLCPIWQPGKPVLPATVQCSADGCTNSKRYSCARTGRPLCYRIECYRS 859 DE D+ L +M DP MTARQR+LL+ ++ +E E + Q P +S R +A ++ +E+++++++ T+E+LLK + SRL R R+L + +D P + +V SY A L P P PA C GC N +RYSC++TG PLC R ECY++ Sbjct: 113 DEVDDE----LRKMKDPTLMTARQRALLESKAQTKERE-ETIPAAAQPPQMSEEMLQRRMQRAKKRKQQAEEKKEKDKKQTIERLLKKS-DSRL--RGRKLARKSDT----PRVSLVQRASGTLLSYPAGVPFPLAPKVAPE---YPAKKMCGIKGCPNPRRYSCSKTGLPLCSR-ECYKT 277
BLAST of INO80 complex subunit B vs. TrEMBL
Match: E0VHV0 (Zinc finger protein HIT domain-containing protein, putative OS=Pediculus humanus subsp. corporis OX=121224 GN=8237500 PE=4 SV=1) HSP 1 Score: 63.5438 bits (153), Expect = 1.644e-7 Identity = 58/201 (28.86%), Postives = 107/201 (53.23%), Query Frame = 2 Query: 260 DAYSSGEEEKKSEIVLEGEDEWSDKECRYLAQMNDPRFMTARQRSLLDKRSGGR-ESNLEEMNFIDQIPALSNRSALRPTGKAGDHXXXXXXXXXXXXXXXXXKLLKVTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSYVAFSDPDLCPIWQPGKPVLPATVQCSADGCTNSKRYSCARTGRPLCYRIECYRS 859 D+ +S EEE+ + + G+ + D+E + + + DP+ MTARQR++L++++ E L + + ++ + R K+ ++ E+++++++ T+E+LLK + A+++ KS P I V+SQ E V +P +P P ++CS DGC N KRYSC++TG PLC + CY++ Sbjct: 83 DSETSSEEERWLDAIQSGKLDEVDEELKKI-KPKDPKLMTARQRAMLERKTDKEPEEQLMSLPSGYKEVVMTAEAIQRKAIKSQKRKQMADEKREKDKKKTMERLLKKQDSKTIKSGAKKI-----TRKSTPQIVYVNSQT-ETKIIVPNGYDFPLTYSKPREP--PMRMKCSVDGCENDKRYSCSKTGFPLC-SLNCYKT 273
BLAST of INO80 complex subunit B vs. TrEMBL
Match: A0A1S3D3W2 (INO80 complex subunit B OS=Diaphorina citri OX=121845 GN=LOC103510037 PE=4 SV=1) HSP 1 Score: 60.4622 bits (145), Expect = 5.380e-7 Identity = 53/190 (27.89%), Postives = 99/190 (52.11%), Query Frame = 2 Query: 359 NDPRFMTARQRSLLDKR-------------SGGRESNLEEMNFIDQIPALSNRSALRPTGKAGDHXXXXXXXXXXXXXXXXXKLLKVTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSY---VAFSDPDLCPIWQPGKPV------LPATVQCSADGCTNSKRYSCARTGRPLCYRIECYRSI 862 DP+ MTARQR++L+++ SG RE + P ++ ++AL K+ ++ E+++++++ T+E+LLK + +K + + + + K P+++++ +Q S+ V F P KP +P+ VQC A CTN+K+Y+C+RTG PLC ++CY++I Sbjct: 13 KDPKLMTARQRAMLERKTDNSSEQLLMSLPSGYREKVM--------TPEMAQKAAL----KSQKRKQQADEKREKDKQKTMERLLK----KQESKSGKIVMKKSTLKKQTPAVKLIRTQDSTLLSFPVDVEF----------PLKPSKIEDLSVPSPVQCGAAECTNTKKYACSRTGIPLC-SLQCYKTI 175
BLAST of INO80 complex subunit B vs. TrEMBL
Match: A0A0C9S2D8 (PAPA-1 domain-containing protein (Fragment) OS=Amblyomma americanum OX=6943 PE=2 SV=1) HSP 1 Score: 60.077 bits (144), Expect = 2.661e-6 Identity = 57/190 (30.00%), Postives = 93/190 (48.95%), Query Frame = 2 Query: 311 GEDEWSDKECRYLAQMNDPRFMTARQRSLLDKRS--GGRESNLEEMNFIDQIPALSNRSALRPTGKAGDHXXXXXXXXXXXXXXXXXKLLK-----VTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSYVAFSDPDLCPIWQPGKPVLPATVQCSADGCTNSKRYSCARTGRPLCYRIECYRS 859 G E D E R +M DP MTARQR+LL+ +S E + + ++ ++ R +A ++ +E+++++++ T+E+LLK + G +LAK+A P+ VS R E + + F P+ G P C GCTN K+YSC++TG PLC +ECY++ Sbjct: 123 GRLEEVDDELR---KMKDPTLMTARQRALLESKSLKDKEEDSPTPLQQVEPAKEMTEEMIQRRMQRAKKRKQQAEEKKEKDKKQTIERLLKKSDSRLRAGKKLAKKADAPPK-------------VSLVRSEAGTMLLFPTGVPFPLAPAGPREYPQRTLCGIKGCTNPKKYSCSKTGVPLCS-LECYKA 295
BLAST of INO80 complex subunit B vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009705.1 (pep scaffold:Pmarinus_7.0:GL478441:15729:30259:1 gene:ENSPMAG00000008770.1 transcript:ENSPMAT00000009705.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 47.3654 bits (111), Expect = 3.269e-6 Identity = 20/31 (64.52%), Postives = 23/31 (74.19%), Query Frame = 2 Query: 764 VQCSADGCTNSKRYSCARTGRPLCYRIECYR 856 + C GCTN KRYSCA+TG PLC +ECYR Sbjct: 271 LDCGVPGCTNRKRYSCAKTGVPLCS-LECYR 300
BLAST of INO80 complex subunit B vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009703.1 (pep scaffold:Pmarinus_7.0:GL478441:15726:30262:1 gene:ENSPMAG00000008770.1 transcript:ENSPMAT00000009703.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 46.9802 bits (110), Expect = 3.700e-6 Identity = 20/31 (64.52%), Postives = 23/31 (74.19%), Query Frame = 2 Query: 764 VQCSADGCTNSKRYSCARTGRPLCYRIECYR 856 + C GCTN KRYSCA+TG PLC +ECYR Sbjct: 279 LDCGVPGCTNRKRYSCAKTGVPLCS-LECYR 308
BLAST of INO80 complex subunit B vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009707.1 (pep scaffold:Pmarinus_7.0:GL478441:15738:30283:1 gene:ENSPMAG00000008770.1 transcript:ENSPMAT00000009707.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 46.9802 bits (110), Expect = 4.122e-6 Identity = 20/31 (64.52%), Postives = 23/31 (74.19%), Query Frame = 2 Query: 764 VQCSADGCTNSKRYSCARTGRPLCYRIECYR 856 + C GCTN KRYSCA+TG PLC +ECYR Sbjct: 298 LDCGVPGCTNRKRYSCAKTGVPLCS-LECYR 327
BLAST of INO80 complex subunit B vs. Planmine SMEST
Match: SMESG000037125.1 (SMESG000037125.1) HSP 1 Score: 406.371 bits (1043), Expect = 2.010e-142 Identity = 232/234 (99.15%), Postives = 233/234 (99.57%), Query Frame = 2 Query: 173 FRNEEMIVXXXXXXXXXXXXXXXGSVVKIDAYSSGEEEKKSEIVLEGEDEWSDKECRYLAQMNDPRFMTARQRSLLDKRSGGRESNLEEMNFIDQIPALSNRSALRPTGKAGDHXXXXXXXXXXXXXXXXXKLLKVTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSYVAFSDPDLCPIWQPGKPVLPATVQCSADGCTNSKRYSCARTGRPLCYRIECYRSIAGTN 874 FRNEEMIVEFMLQEELEKYEEQEGSVVKIDAYSSGEEEKKSEIVLEGEDEWSDKECRYLAQMNDPRFMTARQRSLLDKRSGGRESNLEEMNFIDQIPALSNRSA+RPTGKAGDHRRAVKERQQEEQRVTVEKLLKVTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSYVAFSDPDLCPIWQPGKPVLPATVQCSADGCTNSKRYSCARTGRPLCYRIECYRSIA TN Sbjct: 18 FRNEEMIVEFMLQEELEKYEEQEGSVVKIDAYSSGEEEKKSEIVLEGEDEWSDKECRYLAQMNDPRFMTARQRSLLDKRSGGRESNLEEMNFIDQIPALSNRSAMRPTGKAGDHRRAVKERQQEEQRVTVEKLLKVTPGSRLAKRARQLPQDNDNSKSGPSIRVVSSQRPECPSYVAFSDPDLCPIWQPGKPVLPATVQCSADGCTNSKRYSCARTGRPLCYRIECYRSIADTN 251 The following BLAST results are available for this feature:
BLAST of INO80 complex subunit B vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of INO80 complex subunit B vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of INO80 complex subunit B vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 2
BLAST of INO80 complex subunit B vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of INO80 complex subunit B vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of INO80 complex subunit B vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of INO80 complex subunit B vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of INO80 complex subunit B vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of INO80 complex subunit B vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of INO80 complex subunit B vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 3
BLAST of INO80 complex subunit B vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of INO80 complex subunit B vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of INO80 complex subunit B vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of INO80 complex subunit B vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30028761 ID=SMED30028761|Name=INO80 complex subunit B|organism=Schmidtea mediterranea sexual|type=transcript|length=1248bpback to top protein sequence of SMED30028761-orf-1 >SMED30028761-orf-1 ID=SMED30028761-orf-1|Name=SMED30028761-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=252bp MINSNLSSDDDTCSTLSFRNEEMIVEFMLQEELEKYEEQEGSVVKIDAYSback to top protein sequence of SMED30028761-orf-2 >SMED30028761-orf-2 ID=SMED30028761-orf-2|Name=SMED30028761-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=176bp MQYKCYNDAIDVHDFYTELSRISLTTTAEDLDAGFNCIERNISKILPGNTback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|