Mediator of RNA polymerase II transcription subunit 11

Overview
NameMediator of RNA polymerase II transcription subunit 11
Smed IDSMED30028759
Length (bp)472
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mediator of RNA polymerase II transcription subunit 11 (SMED30028759) t-SNE clustered cells

Violin plots show distribution of expression levels for Mediator of RNA polymerase II transcription subunit 11 (SMED30028759) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mediator of RNA polymerase II transcription subunit 11 (SMED30028759) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mediator of RNA polymerase II transcription subunit 11 (SMED30028759) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30028759

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30028759SMESG000036125.1 dd_Smed_v4_9527_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Human
Match: MED11 (mediator complex subunit 11 [Source:HGNC Symbol;Acc:HGNC:32687])

HSP 1 Score: 57.7658 bits (138), Expect = 6.745e-11
Identity = 24/79 (30.38%), Postives = 47/79 (59.49%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSK 317
            +++  L D+E+ I   L N+G V+ ELSK+K   +  +     F+ S++ ++ E+   + Y+ +++ G PH+GS Y S+
Sbjct:    9 ERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSR 87
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Fly
Match: MED11 (gene:FBgn0036811 transcript:FBtr0075054)

HSP 1 Score: 67.0106 bits (162), Expect = 3.317e-14
Identity = 31/82 (37.80%), Postives = 51/82 (62.20%), Query Frame = 3 
Query:   69 LNLKDKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGS 314
            +N  DKI  L+++EK II  + ++G+ L+EL K+K   K  E   Q F KS+  ++ ++   +NY+ ++S G PH+GS Y S
Sbjct:    1 MNPLDKIHALDEIEKEIILCMQSAGQALQELGKEKSSQKNAETQSQQFLKSLSSVESKLSEQINYLTQVSTGQPHEGSGYAS 82
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Zebrafish
Match: med11 (mediator complex subunit 11 [Source:NCBI gene;Acc:100148504])

HSP 1 Score: 57.3806 bits (137), Expect = 1.015e-10
Identity = 25/79 (31.65%), Postives = 46/79 (58.23%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSK 317
            D++  L DVEK I   L ++G ++ ELSK+K      +  +  F  SI  ++ E+ + + Y+ +++ G PH+GS Y ++
Sbjct:   37 DRLRALEDVEKEIALVLQSAGTIVLELSKEKANASLLDRQLNQFQTSINRVESELSSQIRYLTQVATGQPHEGSTYSAR 115
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Xenopus
Match: peli1 (pellino E3 ubiquitin protein ligase 1 [Source:Xenbase;Acc:XB-GENE-992979])

HSP 1 Score: 53.1434 bits (126), Expect = 3.672e-9
Identity = 22/79 (27.85%), Postives = 47/79 (59.49%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSK 317
            +++  L ++E+ I   L N+G V+ ELSK+K   +  +     F+ S++ ++ E+   + Y+ +++ G PH+GS Y ++
Sbjct:    9 ERLRALEEIEREIAAILLNAGNVILELSKEKPNERVLDKQATQFTASVQRVESELSGQIRYLTQVATGQPHEGSSYSAR 87
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Mouse
Match: Med11 (mediator complex subunit 11 [Source:MGI Symbol;Acc:MGI:1913422])

HSP 1 Score: 56.225 bits (134), Expect = 1.788e-10
Identity = 23/79 (29.11%), Postives = 46/79 (58.23%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSK 317
            +++  L D+E+ I   L N+G  + ELSK+K   +  +     F+ S++ ++ E+   + Y+ +++ G PH+GS Y S+
Sbjct:    9 ERLRALEDIEREIGAILQNAGTAILELSKEKTNERLLDRQAAAFTTSVQHVEAELSAQIRYLTQVATGQPHEGSSYSSR 87
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Mouse
Match: Med11 (mediator complex subunit 11 [Source:MGI Symbol;Acc:MGI:1913422])

HSP 1 Score: 48.1358 bits (113), Expect = 1.901e-7
Identity = 24/89 (26.97%), Postives = 46/89 (51.69%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLE----------ELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSK 317
            +++  L D+E+ I   L N+G   E          ELSK+K   +  +     F+ S++ ++ E+   + Y+ +++ G PH+GS Y S+
Sbjct:    9 ERLRALEDIEREIGAILQNAGSGSEGQTARGTAILELSKEKTNERLLDRQAAAFTTSVQHVEAELSAQIRYLTQVATGQPHEGSSYSSR 97
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. UniProt/SwissProt
Match: sp|Q9VVS4|MED11_DROME (Mediator of RNA polymerase II transcription subunit 11 OS=Drosophila melanogaster OX=7227 GN=MED11 PE=1 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 3.325e-13
Identity = 31/82 (37.80%), Postives = 51/82 (62.20%), Query Frame = 3 
Query:   69 LNLKDKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGS 314
            +N  DKI  L+++EK II  + ++G+ L+EL K+K   K  E   Q F KS+  ++ ++   +NY+ ++S G PH+GS Y S
Sbjct:    1 MNPLDKIHALDEIEKEIILCMQSAGQALQELGKEKSSQKNAETQSQQFLKSLSSVESKLSEQINYLTQVSTGQPHEGSGYAS 82
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. UniProt/SwissProt
Match: sp|Q17NH9|MED11_AEDAE (Mediator of RNA polymerase II transcription subunit 11 OS=Aedes aegypti OX=7159 GN=MED11 PE=3 SV=1)

HSP 1 Score: 58.9214 bits (141), Expect = 1.397e-10
Identity = 28/78 (35.90%), Postives = 47/78 (60.26%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGS 314
            DKI  L+ +EK ++  L ++G+ L ELSK+K   K  E     F KS+  ++ ++   +NY+ ++S G PH+GS Y +
Sbjct:    5 DKIQVLDSIEKELLLCLQSAGQALLELSKEKTSQKATETHTNQFLKSLNIVESKLSEQINYLTQVSTGQPHEGSGYAA 82
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. UniProt/SwissProt
Match: sp|Q32L03|MED11_BOVIN (Mediator of RNA polymerase II transcription subunit 11 OS=Bos taurus OX=9913 GN=MED11 PE=3 SV=1)

HSP 1 Score: 57.7658 bits (138), Expect = 2.678e-10
Identity = 24/79 (30.38%), Postives = 47/79 (59.49%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSK 317
            +++  L D+E+ I   L N+G V+ ELSK+K   +  +     F+ S++ ++ E+   + Y+ +++ G PH+GS Y S+
Sbjct:    9 ERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSR 87
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. UniProt/SwissProt
Match: sp|A3KNK7|MED11_DANRE (Mediator of RNA polymerase II transcription subunit 11 OS=Danio rerio OX=7955 GN=med11 PE=3 SV=2)

HSP 1 Score: 57.7658 bits (138), Expect = 3.097e-10
Identity = 25/79 (31.65%), Postives = 46/79 (58.23%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSK 317
            D++  L DVEK I   L ++G ++ ELSK+K      +  +  F  SI  ++ E+ + + Y+ +++ G PH+GS Y ++
Sbjct:    4 DRLRALEDVEKEIALVLQSAGTIVLELSKEKANASLLDRQLNQFQTSINRVESELSSQIRYLTQVATGQPHEGSTYSAR 82
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. UniProt/SwissProt
Match: sp|Q9P086|MED11_HUMAN (Mediator of RNA polymerase II transcription subunit 11 OS=Homo sapiens OX=9606 GN=MED11 PE=1 SV=2)

HSP 1 Score: 57.7658 bits (138), Expect = 3.239e-10
Identity = 24/79 (30.38%), Postives = 47/79 (59.49%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSK 317
            +++  L D+E+ I   L N+G V+ ELSK+K   +  +     F+ S++ ++ E+   + Y+ +++ G PH+GS Y S+
Sbjct:    9 ERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSR 87
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. TrEMBL
Match: A0A3P7KX60 (Mediator of RNA polymerase II transcription subunit 11 OS=Dibothriocephalus latus OX=60516 GN=MED11 PE=3 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 1.454e-18
Identity = 39/100 (39.00%), Postives = 65/100 (65.00%), Query Frame = 3 
Query:   69 LNLKDKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSKIELENKKNQLYKIQTLL 368
            +NL+D++ KL+DVE  ++  + ++G  LEEL+KDK + KQ +  I  F   +RE++ E+ +HLNY++RIS G P +G++Y   +EL     +L   Q +L
Sbjct:    6 VNLEDRLRKLDDVENKVMLIMQHAGHALEELAKDKPIAKQADAHIHSFRNVVREVETELNSHLNYLSRISAGLPFEGNVYRETVELTLSAERLKIAQRIL 105
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. TrEMBL
Match: A0A183SQR7 (Mediator of RNA polymerase II transcription subunit 11 OS=Schistocephalus solidus OX=70667 GN=MED11 PE=3 SV=1)

HSP 1 Score: 85.1149 bits (209), Expect = 1.673e-18
Identity = 39/100 (39.00%), Postives = 66/100 (66.00%), Query Frame = 3 
Query:   69 LNLKDKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSKIELENKKNQLYKIQTLL 368
            +NL+D++ KL++VE  ++  + ++G  LEELSKDK + KQ +  I  F   +RE++ E+ +HLNY++RIS G P +G++Y   +EL     +L  +Q +L
Sbjct:    6 VNLEDRLRKLDEVENKVMLIMQHAGHALEELSKDKPIAKQADAHIHNFRNVVREVESELNSHLNYLSRISAGLPFEGNVYRETVELTLSAERLKIVQRIL 105
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. TrEMBL
Match: A0A0V0J7C4 (Mediator of RNA polymerase II transcription subunit 11 (Fragment) OS=Schistocephalus solidus OX=70667 GN=MED11 PE=3 SV=1)

HSP 1 Score: 85.8853 bits (211), Expect = 2.455e-18
Identity = 40/109 (36.70%), Postives = 69/109 (63.30%), Query Frame = 3 
Query:   51 PEGTLSLNLKDKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSKIELENKKNQLYKIQTLLENM 377
            P     +NL+D++ KL++VE  ++  + ++G  LEELSKDK + KQ +  I  F   +RE++ E+ +HLNY++RIS G P +G++Y   +EL     +L  +Q +L ++
Sbjct:   36 PMDNAQVNLEDRLRKLDEVENKVMLIMQHAGHALEELSKDKPIAKQADAHIHNFRNVVREVESELNSHLNYLSRISAGLPFEGNVYRETVELTLSAERLKIVQRILMDI 144
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. TrEMBL
Match: A0A4Y7NJP6 (Mediator of RNA polymerase II transcription subunit 11 OS=Megafenestra aurita OX=2291010 GN=EOG090X0LXA PE=2 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 9.220e-16
Identity = 36/101 (35.64%), Postives = 63/101 (62.38%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSKIELENKKNQLYKIQTLLENMTN 383
            +++  L++VEK I   + ++G+ L ELSKDK  MKQ E     F K++  ++ E+  H+NY+ ++S G PH+GS YGS    +  +++L   +T L+++ N
Sbjct:    9 ERLQALDNVEKEIASCIQSAGQALMELSKDKASMKQVESHTSTFLKTLNHVEGELSKHINYLTQVSTGQPHEGSAYGSLKMYKTARHRLEHTRTRLQDLEN 109
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. TrEMBL
Match: A0A4Y7M0B0 (Mediator of RNA polymerase II transcription subunit 11 OS=Daphnia barbata OX=414587 GN=EOG090X0LXA PE=2 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 1.038e-15
Identity = 35/101 (34.65%), Postives = 62/101 (61.39%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSKIELENKKNQLYKIQTLLENMTN 383
            +++  L+ VEK I   + ++G+ L ELSKDK  MKQ E     F K++  ++ E+  H+NY+ ++S G PH+GS YGS    +  ++++   +T L+++ N
Sbjct:    9 ERLQALDSVEKEIASCIQSAGQALTELSKDKASMKQVESHTSQFLKTLNHVESELSKHINYLTQVSTGQPHEGSAYGSVKMYKTARHRIEHTRTRLQDLEN 109
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Cavefish
Match: med11 (mediator complex subunit 11 [Source:NCBI gene;Acc:103027136])

HSP 1 Score: 55.0694 bits (131), Expect = 3.817e-10
Identity = 24/79 (30.38%), Postives = 45/79 (56.96%), Query Frame = 3 
Query:   81 DKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSK 317
            D++  L DVEK I   L  +G ++ ELSK+K      +  +  F  S+  ++ E+ + + Y+ +++ G PH+GS Y ++
Sbjct:    4 DRLRALEDVEKEIAVVLQCAGTIILELSKEKHNASLLDRQLNQFQTSLNRVESELSSQIRYLTQVATGQPHEGSTYSAR 82
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Nematostella
Match: EDO47970 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKV3])

HSP 1 Score: 60.077 bits (144), Expect = 1.498e-12
Identity = 33/113 (29.20%), Postives = 65/113 (57.52%), Query Frame = 3 
Query:   78 KDKISKLNDVEKNIIEALNNSGKVLEELS-----KDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSKIELENK-------KNQLYKIQTLLENMT 380
            +D++ +L ++EK+I++ + ++G+ + ELS     +D + MK  E     F KS+  +++ +   +NY+ +++ G PH+GS YG   + E         K QL ++Q +L+N T
Sbjct:    5 RDRLKQLEEIEKDIVKVMQSAGETIAELSNENPSEDMVNMKATE-----FVKSLEGVEKGLTEQINYLTQVATGQPHEGSTYGVDKDFELATSRTAIVKGQLQEVQKILKNPT 112
[Close]
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Planmine SMEST
Match: SMESG000036125.1 (SMESG000036125.1)

HSP 1 Score: 244.202 bits (622), Expect = 1.464e-84
Identity = 122/122 (100.00%), Postives = 122/122 (100.00%), Query Frame = 3 
Query:   21 MDSNKSIHNRPEGTLSLNLKDKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSKIELENKKNQLYKIQTLLENMTNK 386
            MDSNKSIHNRPEGTLSLNLKDKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSKIELENKKNQLYKIQTLLENMTNK
Sbjct:    1 MDSNKSIHNRPEGTLSLNLKDKISKLNDVEKNIIEALNNSGKVLEELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGSIYGSKIELENKKNQLYKIQTLLENMTNK 122
The following BLAST results are available for this feature:
BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
MED116.745e-1130.38mediator complex subunit 11 [Source:HGNC Symbol;Ac... [more]
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
MED113.317e-1437.80gene:FBgn0036811 transcript:FBtr0075054[more]
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
med111.015e-1031.65mediator complex subunit 11 [Source:NCBI gene;Acc:... [more]
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
peli13.672e-927.85pellino E3 ubiquitin protein ligase 1 [Source:Xenb... [more]
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Med111.788e-1029.11mediator complex subunit 11 [Source:MGI Symbol;Acc... [more]
Med111.901e-726.97mediator complex subunit 11 [Source:MGI Symbol;Acc... [more]
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9VVS4|MED11_DROME3.325e-1337.80Mediator of RNA polymerase II transcription subuni... [more]
sp|Q17NH9|MED11_AEDAE1.397e-1035.90Mediator of RNA polymerase II transcription subuni... [more]
sp|Q32L03|MED11_BOVIN2.678e-1030.38Mediator of RNA polymerase II transcription subuni... [more]
sp|A3KNK7|MED11_DANRE3.097e-1031.65Mediator of RNA polymerase II transcription subuni... [more]
sp|Q9P086|MED11_HUMAN3.239e-1030.38Mediator of RNA polymerase II transcription subuni... [more]
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A3P7KX601.454e-1839.00Mediator of RNA polymerase II transcription subuni... [more]
A0A183SQR71.673e-1839.00Mediator of RNA polymerase II transcription subuni... [more]
A0A0V0J7C42.455e-1836.70Mediator of RNA polymerase II transcription subuni... [more]
A0A4Y7NJP69.220e-1635.64Mediator of RNA polymerase II transcription subuni... [more]
A0A4Y7M0B01.038e-1534.65Mediator of RNA polymerase II transcription subuni... [more]
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
med113.817e-1030.38mediator complex subunit 11 [Source:NCBI gene;Acc:... [more]
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO479701.498e-1229.20Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Mediator of RNA polymerase II transcription subunit 11 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000036125.11.464e-84100.00SMESG000036125.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30028759 ID=SMED30028759|Name=Mediator of RNA polymerase II transcription subunit 11|organism=Schmidtea mediterranea sexual|type=transcript|length=472bp
ATAAATTTCAGAAGTTTGCAATGGATTCAAATAAAAGTATTCATAATAGG
CCAGAAGGTACACTATCACTTAATTTAAAAGATAAAATATCTAAACTTAA
TGACGTGGAAAAGAATATTATTGAAGCTCTAAATAATTCTGGAAAAGTAT
TAGAAGAATTATCCAAAGATAAATTAGTAATGAAACAATGTGAACCTGTT
ATTCAAGGATTTTCAAAATCTATTCGAGAAATTGATCAAGAGATACAAAA
TCATTTAAATTATATTAATAGAATTTCTATGGGATATCCCCATGATGGTA
GTATATATGGCAGTAAAATCGAATTAGAAAATAAGAAAAATCAACTATAT
AAAATTCAAACATTGTTAGAGAACATGACAAATAAATAAGTCGATTTTTT
ATAAAGTTGTAAATTAACTTTTTGTTTCTGTAATTTCAGCAGATTCATAT
TTTAAGTAAATGTTTTTATGTT
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protein sequence of SMED30028759-orf-1

>SMED30028759-orf-1 ID=SMED30028759-orf-1|Name=SMED30028759-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=129bp
KFQKFAMDSNKSIHNRPEGTLSLNLKDKISKLNDVEKNIIEALNNSGKVL
EELSKDKLVMKQCEPVIQGFSKSIREIDQEIQNHLNYINRISMGYPHDGS
IYGSKIELENKKNQLYKIQTLLENMTNK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0003712transcription cofactor activity
GO:0001104RNA polymerase II transcription cofactor activity
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0016020membrane
GO:0016021integral component of membrane
GO:0016592mediator complex
Vocabulary: biological process
TermDefinition
GO:0006357regulation of transcription from RNA polymerase II promoter
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 25..45
NoneNo IPR availableCOILSCoilCoilcoord: 108..128