Epsin 2

Overview


Name	Epsin 2
Smed ID	SMED30028718
Length (bp)	2489

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Epsin 2 (SMED30028718) t-SNE clustered cells

Violin plots show distribution of expression levels for Epsin 2 (SMED30028718) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Epsin 2 (SMED30028718) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Epsin 2 (SMED30028718) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30028718

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 9

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
pharynx	SMED30028718	SMESG000042233.1	dd_Smed_v4_4779_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
protonephridia	SMED30028718	SMESG000042233.1	dd_Smed_v4_4779_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30028718	SMESG000042233.1	dd_Smed_v4_4779_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
gut	SMED30028718	SMESG000042233.1	dd_Smed_v4_4779_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30028718	SMESG000042233.1	dd_Smed_v4_4779_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30028718	SMESG000042233.1	dd_Smed_v4_4779_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30028718	SMESG000042233.1	dd_Smed_v4_4779_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30028718	SMESG000042233.1	dd_Smed_v4_4779_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30028718	SMESG000042233.1	dd_Smed_v4_4779_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Epsin 2 vs. Ensembl Human
Match: EPN2 (epsin 2 [Source:HGNC Symbol;Acc:HGNC:18639])

HSP 1 Score: 233.032 bits (593), Expect = 2.617e-66
Identity = 134/352 (38.07%), Postives = 196/352 (55.68%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQ------HRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATA----TNVKSQDSSIPLDFDPWKS 1098
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +  AF +IM ++WKRLND GKNWRHVYK+L LLDYL+K G+ER+A++C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD+E L  ER++ LK KE+     + +GS+Q        +P        +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+++                               K  K+     L + + + D  +   SS     K++PWG +A    TN     ++     DPW S
Sbjct:    6 IRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLR----RGDDLRLQMALEESRRDT-----------------------------VKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSASTNQTNPWGGPAAPASTSDPWPS 324

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Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQ------HRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATA----TNVKSQDSSIPLDFDPWKS 1098
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +  AF +IM ++WKRLND GKNWRHVYK+L LLDYL+K G+ER+A++C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD+E L  ER++ LK KE+     + +GS+Q        +P        +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+++                               K  K+     L + + + D  +   SS     K++PWG +A    TN     ++     DPW S
Sbjct:    6 IRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLR----RGDDLRLQMALEESRRDT-----------------------------VKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSASTNQTNPWGGPAAPASTSDPWPS 324

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BLAST of Epsin 2 vs. Ensembl Human
Match: EPN2 (epsin 2 [Source:HGNC Symbol;Acc:HGNC:18639])

HSP 1 Score: 227.639 bits (579), Expect = 3.666e-66
Identity = 135/365 (36.99%), Postives = 200/365 (54.79%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQ------HRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTP 1149
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +  AF +IM ++WKRLND GKNWRHVYK+L LLDYL+K G+ER+A++C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD+E L  ER++ LK KE+     + +GS+Q        +P        +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+++                               K  K+     L + + + D  +   SS     K++PWG +A+  ++         +PW  P         P +TS P
Sbjct:    6 IRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLR----RGDDLRLQMALEESRRD-----------------------------TVKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSASTNQT---------NPWGGP-------AAPASTSDP 321

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BLAST of Epsin 2 vs. Ensembl Human
Match: EPN2 (epsin 2 [Source:HGNC Symbol;Acc:HGNC:18639])

HSP 1 Score: 230.72 bits (587), Expect = 1.898e-65
Identity = 117/257 (45.53%), Postives = 169/257 (65.76%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQ------HRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE 825
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +  AF +IM ++WKRLND GKNWRHVYK+L LLDYL+K G+ER+A++C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD+E L  ER++ LK KE+     + +GS+Q        +P        +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+++
Sbjct:    6 IRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLR----RGDDLRLQMALEESRRD 258

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BLAST of Epsin 2 vs. Ensembl Human
Match: EPN1 (epsin 1 [Source:HGNC Symbol;Acc:HGNC:21604])

HSP 1 Score: 229.95 bits (585), Expect = 3.791e-65
Identity = 142/378 (37.57%), Postives = 205/378 (54.23%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI--------EDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSK-----KEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPL-----DFDPWKSPDNNFGSSKTPM--NTSTPDVWLNKDS 1173
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER++++C +N++ ++TLKDFQY + + KD GV +REK+K LV LL+D++ L  ER+  LK KEK     ++  +     P     +   Q + + +     ++L    +K E         EDD +LQ A+ LS+EEH++  +IR    R ++L++++A+E+SK     KEE    +   V     P P         T             +  A+   D   G      V   +DPWG  A    S D   P        DPW       G +  P      TPD W + D 
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEEL---QLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIR----RGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAP---------TTDPWGGPAPMAAAVPTAAPTSDPWGGP----PVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPW-------GGTPAPAAGEGPTPDPWGSSDG 356

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BLAST of Epsin 2 vs. Ensembl Celegans
Match: epn-1 (EPsiN (Endocytic protein) homolog [Source:UniProtKB/TrEMBL;Acc:Q9BI72])

HSP 1 Score: 239.195 bits (609), Expect = 4.878e-70
Identity = 133/313 (42.49%), Postives = 195/313 (62.30%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI---EDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGA 1035
            IRR+VKNV Y +S+A+  VREATSNDPWGPS+ LMSEIAD+T++  AF +IM ++WKRLND GKNWRHVYKSLVLLD+L+KCG+E++A++C +N+ TIETLKDFQ+ E+++D G+ IREK+K +  LL D E L NER++ +  + KF          +   PG +G E R+  +  +      +   +E+ +      E+ +LQ A+ LS+EE E+A ++R+ ++ R    +++ALE+S+K ++ DR     LA  +    VS  Q  ++ L      D L  L     +    N   SS      +DPWGA
Sbjct:    6 IRRQVKNVAYNFSDAQVKVREATSNDPWGPSTALMSEIADLTHNPMAFTEIMSIVWKRLNDSGKNWRHVYKSLVLLDFLIKCGHEKVAQQCRENVFTIETLKDFQHVEDNRDQGLNIREKAKQITSLLSDDERLKNERTRFILTRNKF----------KQNNPGPVGAESRR--SNRHHVTDASLDPEYEDARPSTATEEEMQLQIALALSREECEKADEMRKSDDAR----LQMALEESQKLQDADR-----LATTK-QGTVSSGQLTQSAL------DDLLSLG-VGELVSGNNDQPSSSSAWGMNDPWGA 289

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BLAST of Epsin 2 vs. Ensembl Celegans
Match: epn-1 (EPsiN (Endocytic protein) homolog [Source:UniProtKB/TrEMBL;Acc:Q9BI72])

HSP 1 Score: 234.958 bits (598), Expect = 1.273e-68
Identity = 133/313 (42.49%), Postives = 194/313 (61.98%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI---EDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGA 1035
            IRR+VKNV Y +S+A+  VREATSNDPWGPS+ LMSEIAD+T++  AF +IM ++WKRLND GKNWRHVYKSLVLLD+L+KCG+E++A++C +N+ TIETLKDFQ+ E+++D G+ IREK+K +  LL D E L NER++ +  + KF          +   PG +G E R+  +  +      +   +E+ +      E+ +LQ A+ LS+EE E+A ++R+ ++ R    +++ALE+S+K+   DR     LA  +    VS  Q  ++ L      D L  L     +    N   SS      +DPWGA
Sbjct:    6 IRRQVKNVAYNFSDAQVKVREATSNDPWGPSTALMSEIADLTHNPMAFTEIMSIVWKRLNDSGKNWRHVYKSLVLLDFLIKCGHEKVAQQCRENVFTIETLKDFQHVEDNRDQGLNIREKAKQITSLLSDDERLKNERTRFILTRNKF----------KQNNPGPVGAESRR--SNRHHVTDASLDPEYEDARPSTATEEEMQLQIALALSREECEKADEMRKSDDAR----LQMALEESQKDA--DR-----LATTK-QGTVSSGQLTQSAL------DDLLSLG-VGELVSGNNDQPSSSSAWGMNDPWGA 287

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BLAST of Epsin 2 vs. Ensembl Celegans
Match: rsd-3 (pep chromosome:WBcel235:X:11798505:11803656:1 gene:WBGene00004682.1 transcript:C34E11.1.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:rsd-3)

HSP 1 Score: 97.4413 bits (241), Expect = 6.537e-21
Identity = 51/145 (35.17%), Postives = 87/145 (60.00%), Query Frame = 1

Query:  103 EIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNS--YSAFDDIMQLIWKRLNDKGKN-WRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEE-HKDLGVGIREKSKALVILLKDKEILTNERSK 525
            ++   + + +  Y +A   VREAT+ DPWGP+   M +I + T S     F ++   +++R+ +  K+ WR VYKSL+LLDYL+K G+ER  +E  +  + +  L+ ++Y +E  KD G+ IR + K ++ ++ D E+L  ER K
Sbjct:   27 KVTESMNDAIMNYPKAMMDVREATNEDPWGPTGPQMKKICEYTRSRYMEDFYNVYTPLFQRMLENNKDAWRRVYKSLILLDYLLKNGSERFVQEAREKAYELRRLESYKYIDEKGKDQGINIRHRVKQILEMMNDDELLQAERQK 171

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BLAST of Epsin 2 vs. Ensembl Fly
Match: lqf (gene:FBgn0028582 transcript:FBtr0331833)

HSP 1 Score: 231.876 bits (590), Expect = 9.675e-66
Identity = 134/330 (40.61%), Postives = 197/330 (59.70%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPW 1092
            +RR +KN+ + YS+A+  VREATSNDPWGPS+ +MSEIA++T +  AF +IMQ+IWKRLND GKNWRHVYK+L+LL+YL+K G+E++A++C +NI  I+TL++F YFEE KD G  +REK+K LV LLKD E L NER K  K KE+F    S  GS  +   G   R++   + ++   P++V +L     ++  E++ +LQ A+ +S+EE E      Q+E +R    ++L L  S+ E++F   N + +    P PK  ++Q++   L       SL   S +S       G  +++      DPW        SQ S      DPW
Sbjct:    8 LRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEEGKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSGFGSDGYID-GPSQRDLPPGWQEEP--PKSVSELEMVRPQTAGEEELQLQLAMAMSREEAE------QEEAKRRSDDVRLQLALSQSEQDFKDPNGRPI----PAPKKEEQQSHLLDLLDI----SLGATSISSPPLGAAGGAPTAV-----VDPWAMPGPRAPSQLS------DPW 309

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BLAST of Epsin 2 vs. Ensembl Fly
Match: lqf (gene:FBgn0028582 transcript:FBtr0331838)

HSP 1 Score: 231.876 bits (590), Expect = 9.675e-66
Identity = 134/330 (40.61%), Postives = 197/330 (59.70%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPW 1092
            +RR +KN+ + YS+A+  VREATSNDPWGPS+ +MSEIA++T +  AF +IMQ+IWKRLND GKNWRHVYK+L+LL+YL+K G+E++A++C +NI  I+TL++F YFEE KD G  +REK+K LV LLKD E L NER K  K KE+F    S  GS  +   G   R++   + ++   P++V +L     ++  E++ +LQ A+ +S+EE E      Q+E +R    ++L L  S+ E++F   N + +    P PK  ++Q++   L       SL   S +S       G  +++      DPW        SQ S      DPW
Sbjct:    8 LRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEEGKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSGFGSDGYID-GPSQRDLPPGWQEEP--PKSVSELEMVRPQTAGEEELQLQLAMAMSREEAE------QEEAKRRSDDVRLQLALSQSEQDFKDPNGRPI----PAPKKEEQQSHLLDLLDI----SLGATSISSPPLGAAGGAPTAV-----VDPWAMPGPRAPSQLS------DPW 309

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BLAST of Epsin 2 vs. Ensembl Fly
Match: lqf (gene:FBgn0028582 transcript:FBtr0112941)

HSP 1 Score: 231.876 bits (590), Expect = 1.259e-65
Identity = 134/330 (40.61%), Postives = 197/330 (59.70%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPW 1092
            +RR +KN+ + YS+A+  VREATSNDPWGPS+ +MSEIA++T +  AF +IMQ+IWKRLND GKNWRHVYK+L+LL+YL+K G+E++A++C +NI  I+TL++F YFEE KD G  +REK+K LV LLKD E L NER K  K KE+F    S  GS  +   G   R++   + ++   P++V +L     ++  E++ +LQ A+ +S+EE E      Q+E +R    ++L L  S+ E++F   N + +    P PK  ++Q++   L       SL   S +S       G  +++      DPW        SQ S      DPW
Sbjct:    8 LRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEEGKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSGFGSDGYID-GPSQRDLPPGWQEEP--PKSVSELEMVRPQTAGEEELQLQLAMAMSREEAE------QEEAKRRSDDVRLQLALSQSEQDFKDPNGRPI----PAPKKEEQQSHLLDLLDI----SLGATSISSPPLGAAGGAPTAV-----VDPWAMPGPRAPSQLS------DPW 309

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BLAST of Epsin 2 vs. Ensembl Fly
Match: lqf (gene:FBgn0028582 transcript:FBtr0331835)

HSP 1 Score: 231.876 bits (590), Expect = 1.275e-65
Identity = 144/366 (39.34%), Postives = 210/366 (57.38%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQ------DSSIPLDFDPW---KSPDNNFGSSKTPMNTSTP-----DVW 1158
            +RR +KN+ + YS+A+  VREATSNDPWGPS+ +MSEIA++T +  AF +IMQ+IWKRLND GKNWRHVYK+L+LL+YL+K G+E++A++C +NI  I+TL++F YFEE KD G  +REK+K LV LLKD E L NER K  K KE+F    S  GS  +   G   R++   + ++   P++V +L     ++  E++ +LQ A+ +S+EE E      Q+E +R    ++L L  S+ E++F   N + +    P PK  ++Q++   L       SL   S +S       G  +++      DPW        SQ       +S P   DPW    +P    G+   PM TS P     D W
Sbjct:   15 LRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEEGKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSGFGSDGYID-GPSQRDLPPGWQEEP--PKSVSELEMVRPQTAGEEELQLQLAMAMSREEAE------QEEAKRRSDDVRLQLALSQSEQDFKDPNGRPI----PAPKKEEQQSHLLDLLDI----SLGATSISSPPLGAAGGAPTAV-----VDPWAMPGPRAPSQLSDPWSGTSSP-QVDPWNPSAAPRTILGAG-VPM-TSAPLGAGNDAW 355

[Close]

BLAST of Epsin 2 vs. Ensembl Fly
Match: lqf (gene:FBgn0028582 transcript:FBtr0331837)

HSP 1 Score: 232.261 bits (591), Expect = 8.951e-65
Identity = 134/330 (40.61%), Postives = 197/330 (59.70%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPW 1092
            +RR +KN+ + YS+A+  VREATSNDPWGPS+ +MSEIA++T +  AF +IMQ+IWKRLND GKNWRHVYK+L+LL+YL+K G+E++A++C +NI  I+TL++F YFEE KD G  +REK+K LV LLKD E L NER K  K KE+F    S  GS  +   G   R++   + ++   P++V +L     ++  E++ +LQ A+ +S+EE E      Q+E +R    ++L L  S+ E++F   N + +    P PK  ++Q++   L       SL   S +S       G  +++      DPW        SQ S      DPW
Sbjct:    8 LRRNIKNLAHNYSDAQVKVREATSNDPWGPSAAIMSEIAELTYNVVAFSEIMQMIWKRLNDHGKNWRHVYKALILLEYLIKTGSEKVAQQCKENIFAIQTLREFVYFEEGKDQGTHVREKAKQLVTLLKDDERLKNERVKAQKAKERFAQNPSGFGSDGYID-GPSQRDLPPGWQEEP--PKSVSELEMVRPQTAGEEELQLQLAMAMSREEAE------QEEAKRRSDDVRLQLALSQSEQDFKDPNGRPI----PAPKKEEQQSHLLDLLDI----SLGATSISSPPLGAAGGAPTAV-----VDPWAMPGPRAPSQLS------DPW 309

[Close]

BLAST of Epsin 2 vs. Ensembl Zebrafish
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 238.039 bits (606), Expect = 3.111e-68
Identity = 147/359 (40.95%), Postives = 204/359 (56.82%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGE------LGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDS----LYKLSEASRIFDQQNGDLSSLDVDTKSDPWG-----ATATNVKSQD----SSIPLDFDPW 1092
            IRR++KNVV  YSE EK VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK+L LLDYL+K G+ER+A +C +NI  I+TLKDFQY + + KD G+ +REKSK LV+LLKD + L  ERS+ LK KE+     +S+GS+     G       L     +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+K    D +  KV    + PP+ S     + +    A + +        + A    D      ++       DPWG     ++AT VKS D    SS P   DPW
Sbjct:    6 IRRQMKNVVNNYSEPEKKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVVLLKDDDRLKGERSQALKTKERMAQVATSVGSNNQIGFGRGSSQPNLSTSYSEEYGKSEGSPASYHGSTSPNASSELEQARPQTSGEEELQLQLALAMSREAAEQEERMR----RGDDLRLQMALEESRK----DTSTGKVSKKKKEPPQSSLMDLMDAVPEGHANQGTDPWGAGAAAAAGPTSDPWQSYGAAPKPAAPVDPWGLPGASSSATPVKSTDPWGSSSAPAAADPW 356

[Close]

BLAST of Epsin 2 vs. Ensembl Zebrafish
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 234.958 bits (598), Expect = 1.044e-67
Identity = 147/364 (40.38%), Postives = 202/364 (55.49%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGE------LGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWG-----ATATNVKSQD----SSIPLDFDPWKSPDNNFGS 1119
            IRR++KNVV  YSE EK VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK+L LLDYL+K G+ER+A +C +NI  I+TLKDFQY + + KD G+ +REKSK LV+LLKD + L  ERS+ LK KE+     +S+GS+     G       L     +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+K    D +  KV            K+  E        +   + +S    ++ +      S       DPWG     ++AT VKS D    SS P   DPW       GS
Sbjct:    6 IRRQMKNVVNNYSEPEKKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVVLLKDDDRLKGERSQALKTKERMAQVATSVGSNNQIGFGRGSSQPNLSTSYSEEYGKSEGSPASYHGSTSPNASSELEQARPQTSGEEELQLQLALAMSREAAEQEERMR----RGDDLRLQMALEESRK----DTSTGKV-----------SKKKKEV----GTDQTECFSVSVDLHLWPRST---FSPKPAAPVDPWGLPGASSSATPVKSTDPWGSSSAPAAADPWGPMPATLGS 343

[Close]

BLAST of Epsin 2 vs. Ensembl Zebrafish
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 235.728 bits (600), Expect = 1.473e-67
Identity = 122/257 (47.47%), Postives = 168/257 (65.37%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGE------LGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE 825
            IRR++KNVV  YSE EK VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK+L LLDYL+K G+ER+A +C +NI  I+TLKDFQY + + KD G+ +REKSK LV+LLKD + L  ERS+ LK KE+     +S+GS+     G       L     +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+K+
Sbjct:    6 IRRQMKNVVNNYSEPEKKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVVLLKDDDRLKGERSQALKTKERMAQVATSVGSNNQIGFGRGSSQPNLSTSYSEEYGKSEGSPASYHGSTSPNASSELEQARPQTSGEEELQLQLALAMSREAAEQEERMR----RGDDLRLQMALEESRKD 258

[Close]

BLAST of Epsin 2 vs. Ensembl Zebrafish
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 227.254 bits (578), Expect = 5.573e-67
Identity = 128/278 (46.04%), Postives = 176/278 (63.31%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGE------LGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVS 888
            IRR++KNVV  YSE EK VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK+L LLDYL+K G+ER+A +C +NI  I+TLKDFQY + + KD G+ +REKSK LV+LLKD + L  ERS+ LK KE+     +S+GS+     G       L     +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+K    D +  KV    + PP+ S
Sbjct:    6 IRRQMKNVVNNYSEPEKKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVVLLKDDDRLKGERSQALKTKERMAQVATSVGSNNQIGFGRGSSQPNLSTSYSEEYGKSEGSPASYHGSTSPNASSELEQARPQTSGEEELQLQLALAMSREAAEQEERMR----RGDDLRLQMALEESRK----DTSTGKVSKKKKEPPQSS 275

[Close]

BLAST of Epsin 2 vs. Ensembl Zebrafish
Match: epn1 (epsin 1 [Source:ZFIN;Acc:ZDB-GENE-040426-2680])

HSP 1 Score: 231.106 bits (588), Expect = 3.344e-65
Identity = 140/380 (36.84%), Postives = 204/380 (53.68%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRT----------VMKLNFEE-----------TKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRD-SLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSR 1176
            +RR+VKN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM ++WKRLND GKNWRHVYK++ L++YL+K G+ER+A++C +NI+ ++TLKDFQY + + KD GV +REK+K LV LLKD+E L  ER   LK KEK     S+  +      G  G  +      D  +P++           + ++ EE           T   +ED E++ A+ +S+E H++  ++R    R ++L++++A+E+SK+E+                     K    +L+  SA           A        G  S+       DPWGAT+        + P   DPW       G+      T  PD W +  SR
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVAQQCRENIYAVQTLKDFQYIDRDGKDQGVNVREKAKQLVTLLKDEERLREERIHALKTKEKMAQTSSASSAPSAPALG--GGGVHSGADSDQAWPQSSGEEDLQLQLALAMSKEEAEQKRPCCDKTTHDPLEDAEIRYALTISQETHQQEERLR----RGDDLRLQMAIEESKREKT--------------------KPEESSLMELSAADPWGAPATGSAGPSPPPALGPASTAGPWGPPDPWGATSP-------ASPPSADPWA------GAPA----TVAPDPWSDSSSR 342

[Close]

BLAST of Epsin 2 vs. Ensembl Xenopus
Match: uvssa (UV stimulated scaffold protein A [Source:Xenbase;Acc:XB-GENE-5833232])

HSP 1 Score: 238.81 bits (608), Expect = 5.154e-68
Identity = 144/366 (39.34%), Postives = 200/366 (54.64%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEE---RREELKIKLALEQSKKEEEFDRNNQKVLA----VLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPW-GATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTP------MNTSTPDVW 1158
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER+A++C +NI+ I+TLKDFQY + + KD GV +REK+K LV LLKD E L  ER+  LK KEK     +S  +     P     +   Q + +                   E+ +LQ A+ +SKEE E   ++R  EE   R ++L++++A+E+SKKE    +  Q  L     V  PP  V             A     +  S A                   +DPW G  AT      S++P   DPW  P    G+S  P      +N+++ D W
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVAQQCKENIYAIQTLKDFQYVDRDGKDQGVNVREKAKQLVSLLKDDERLKEERAHALKTKEKLAQTSTSSSASSTLNPATEAEQAWPQSSGE-------------------EELQLQLALAMSKEEAE---QVRAKEERIRRGDDLRLQMAIEESKKEAPSKQEEQSSLMDLADVFSPPAPV-------------AASAGPWGASAAP-----------------PADPWAGGVAT------STLPAASDPWGGPPVATGASSDPWGTGAQINSTSADPW 313

[Close]

BLAST of Epsin 2 vs. Ensembl Xenopus
Match: uvssa (UV stimulated scaffold protein A [Source:Xenbase;Acc:XB-GENE-5833232])

HSP 1 Score: 238.039 bits (606), Expect = 9.873e-68
Identity = 206/629 (32.75%), Postives = 309/629 (49.13%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI------------EDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLA----VLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPW-GATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTP------MNTSTPDVWLNKDSRQSKNI--VDDIF--GDEKPNTQFASN--WNFDVNGLTPSNQNKIIDSNPWEE----SDSSFGQLTKNTT-GSLASLTDIGNDLSREKKHSCSVTDLLD--------TNTSTNKKKTPQEFXXXXXXXXXXXXXXPIPKAGVYRDPMSHVAK--NPFGMTAS--AVVSNPF--NNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFT------TPMQPTFPISH-SQYQGFSTMNNFSNIP 1824
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER+A++C +NI+ I+TLKDFQY + + KD GV +REK+K LV LLKD E L  ER+  LK KEK     +S  +     P     +   Q + + +     ++L    +K E             E+ +LQ A+ LSKEEH++  +IR    R ++L++++A+E+SKKE    +  Q  L     V  PP  V             A     +  S A                   +DPW G  AT      S++P   DPW  P    G+S  P      +N+++ D W    +  + ++  V D +  G     T   +N  W+       P  Q+    ++PW      SD   G  +K +T G++  L  +  ++   +       D  D        +++    +KTP+ FLG NA LV+L++        +   P    AK  NPF +T +  A  +NPF  N Q+    + +NQ+ +S   +      +T  G     +  FT      +PM P  PI++ +   G   M    N+P
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVAQQCKENIYAIQTLKDFQYVDRDGKDQGVNVREKAKQLVSLLKDDERLKEERAHALKTKEKLAQTSTSSSASSTLNPATEAEQAWPQSSGEEEL---QLQLALAMSKEEAEQVRAKPPAVSEEELQLQLALSLSKEEHDKEERIR----RGDDLRLQMAIEESKKEAPSKQEEQSSLMDLADVFSPPAPV-------------AASAGPWGASAAP-----------------PADPWAGGVAT------STLPAASDPWGGPPVATGASSDPWGTGAQINSTSADPWGGTQAVTTADVKAVSDPWNPGGSTATTGIPNNDPWSSS----PPVAQSVKKAADPWAPAASFSDPWGGSPSKPSTNGTMGELDLLAGEVPMSRSLGSKSPDTFDMTAMSGSLSDSCKPTRKTPESFLGPNAALVDLDS--------LISKPALQNAKTSNPFLVTGTPNATTTNPFQPNQQS---SLTLNQLRSS--PVMTLGQPVTPAGQTPATI-PFTSPMVSVSPMAPGIPIANVAPMVGMQPMAGVPNLP 573

[Close]

BLAST of Epsin 2 vs. Ensembl Xenopus
Match: uvssa (UV stimulated scaffold protein A [Source:Xenbase;Acc:XB-GENE-5833232])

HSP 1 Score: 234.572 bits (597), Expect = 3.333e-66
Identity = 147/375 (39.20%), Postives = 207/375 (55.20%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI------------EDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLA----VLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPW-GATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTP------MNTSTPDVW 1158
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER+A++C +NI+ I+TLKDFQY + + KD GV +REK+K LV LLKD E L  ER+  LK KEK     +S  +     P     +   Q + + +     ++L    +K E             E+ +LQ A+ LSKEEH++  +IR    R ++L++++A+E+SKKE    +  Q  L     V  PP  V             A     +  S A                   +DPW G  AT      S++P   DPW  P    G+S  P      +N+++ D W
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVAQQCKENIYAIQTLKDFQYVDRDGKDQGVNVREKAKQLVSLLKDDERLKEERAHALKTKEKLAQTSTSSSASSTLNPATEAEQAWPQSSGEEEL---QLQLALAMSKEEAEQVRAKPPAVSEEELQLQLALSLSKEEHDKEERIR----RGDDLRLQMAIEESKKEAPSKQEEQSSLMDLADVFSPPAPV-------------AASAGPWGASAAP-----------------PADPWAGGVAT------STLPAASDPWGGPPVATGASSDPWGTGAQINSTSADPW 337

[Close]

BLAST of Epsin 2 vs. Ensembl Xenopus
Match: epn2 (epsin2 [Source:NCBI gene;Acc:448609])

HSP 1 Score: 227.254 bits (578), Expect = 3.565e-64
Identity = 147/383 (38.38%), Postives = 205/383 (53.52%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGE------LGREIRKQ-FTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDT--KSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTP-DVWLNKDSRQSKNI 1191
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +  AF +IM +IWKRLND GKNWRHVYK+L LLDYL+K G+ER++ +C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD E L  ER++ LK KE+     + + S+     G       L     +Q + K    P +          SE+E            +LQ A+ +S+E  E+  +IR    R ++L++++ALE+S+K              ++ P K + +Q     L  +            S     Q  D  +  V T  KSDPW   A +        P   DPW+S    FGS      T+ P D W  K    ++++
Sbjct:    6 IRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVSHQCKENIFAIQTLKDFQYMDRDGKDQGINVREKSKQLVCLLKDDERLKGERAQALKTKERMAQVATGVSSNNQITFGRGSSQPNLSTSYSEQDYGKSGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERIR----RGDDLRLQMALEESRKH------------TIKAPRKKAQQQTTLLDLLDALP----------SGAPAPQKPDTWAAAVATKSKSDPWNVAAVS--------PSSSDPWQS----FGSG---TKTAAPQDPWGGKAGPSTQSL 347

[Close]

BLAST of Epsin 2 vs. Ensembl Xenopus
Match: epn2 (epsin2 [Source:NCBI gene;Acc:448609])

HSP 1 Score: 224.557 bits (571), Expect = 3.045e-63
Identity = 148/390 (37.95%), Postives = 207/390 (53.08%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGE------LGREIRKQ-FTKDNQFPRT-------VMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDT--KSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTP-DVWLNKDSRQSKNI 1191
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +  AF +IM +IWKRLND GKNWRHVYK+L LLDYL+K G+ER++ +C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD E L  ER++ LK KE+     + + S+     G       L     +Q + K    P +       V+        SE+E            +LQ A+ +S+E  E+  +IR    R ++L++++ALE+S+K              ++ P K + +Q     L  +            S     Q  D  +  V T  KSDPW   A +        P   DPW+S    FGS      T+ P D W  K    ++++
Sbjct:    6 IRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVSHQCKENIFAIQTLKDFQYMDRDGKDQGINVREKSKQLVCLLKDDERLKGERAQALKTKERMAQVATGVSSNNQITFGRGSSQPNLSTSYSEQDYGKSGGSPASYHGFMCNVLAATSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERIR----RGDDLRLQMALEESRKH------------TIKAPRKKAQQQTTLLDLLDALP----------SGAPAPQKPDTWAAAVATKSKSDPWNVAAVS--------PSSSDPWQS----FGSG---TKTAAPQDPWGGKAGPSTQSL 354

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BLAST of Epsin 2 vs. Ensembl Mouse
Match: Epn1 (epsin 1 [Source:MGI Symbol;Acc:MGI:1333763])

HSP 1 Score: 236.884 bits (603), Expect = 7.143e-68
Identity = 141/376 (37.50%), Postives = 208/376 (55.32%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI--------EDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE----EEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPL-----DFDPWKSPDNNFGSSKTPM--NTSTPDVWLNKD 1170
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER++++C +N++ ++TLKDFQY + + KD GV +REK+K LV LL+D++ L  ER+  LK KEK     ++  +     P     +   Q + + +     ++L    +K E         EDD +LQ A+ LS+EEH++  +IR    R ++L++++A+E+SK+E    EE    +   +     PP+ SD       +  +    +           D   G      V   +DPWG  A    S D   P        DPW       G +  P      TPD W + D
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEEL---QLQLALAMSKEEADQPPSCGPEDDVQLQLALSLSREEHDKEERIR----RGDDLRLQMAIEESKRETGGKEESSLMDLADVFTTPAPPQASDPWGGPASVPTAVPVAAAAS--------DPWGGPA----VPPAADPWGGAAPTPASGDPWRPAAPTGPSVDPW-------GGTPAPAAGEGPTPDPWGSSD 355

[Close]

BLAST of Epsin 2 vs. Ensembl Mouse
Match: Epn1 (epsin 1 [Source:MGI Symbol;Acc:MGI:1333763])

HSP 1 Score: 236.884 bits (603), Expect = 7.967e-68
Identity = 141/376 (37.50%), Postives = 208/376 (55.32%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI--------EDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE----EEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPL-----DFDPWKSPDNNFGSSKTPM--NTSTPDVWLNKD 1170
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER++++C +N++ ++TLKDFQY + + KD GV +REK+K LV LL+D++ L  ER+  LK KEK     ++  +     P     +   Q + + +     ++L    +K E         EDD +LQ A+ LS+EEH++  +IR    R ++L++++A+E+SK+E    EE    +   +     PP+ SD       +  +    +           D   G      V   +DPWG  A    S D   P        DPW       G +  P      TPD W + D
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEEL---QLQLALAMSKEEADQPPSCGPEDDVQLQLALSLSREEHDKEERIR----RGDDLRLQMAIEESKRETGGKEESSLMDLADVFTTPAPPQASDPWGGPASVPTAVPVAAAAS--------DPWGGPA----VPPAADPWGGAAPTPASGDPWRPAAPTGPSVDPW-------GGTPAPAAGEGPTPDPWGSSD 355

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Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI--------EDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE----EEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPL-----DFDPWKSPDNNFGSSKTPM--NTSTPDVWLNKD 1170
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER++++C +N++ ++TLKDFQY + + KD GV +REK+K LV LL+D++ L  ER+  LK KEK     ++  +     P     +   Q + + +     ++L    +K E         EDD +LQ A+ LS+EEH++  +IR    R ++L++++A+E+SK+E    EE    +   +     PP+ SD       +  +    +           D   G      V   +DPWG  A    S D   P        DPW       G +  P      TPD W + D
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEEL---QLQLALAMSKEEADQPPSCGPEDDVQLQLALSLSREEHDKEERIR----RGDDLRLQMAIEESKRETGGKEESSLMDLADVFTTPAPPQASDPWGGPASVPTAVPVAAAAS--------DPWGGPA----VPPAADPWGGAAPTPASGDPWRPAAPTGPSVDPW-------GGTPAPAAGEGPTPDPWGSSD 355

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BLAST of Epsin 2 vs. Ensembl Mouse
Match: Epn2 (epsin 2 [Source:MGI Symbol;Acc:MGI:1333766])

HSP 1 Score: 230.335 bits (586), Expect = 2.124e-65
Identity = 117/257 (45.53%), Postives = 168/257 (65.37%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQ------HRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE 825
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +  AF +IM ++WKRLND GKNWRHVYK+L LLDYL+K G+ER+A++C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD+E L  ER + LK KE+     + +GS+Q        +P        +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+++
Sbjct:    6 IRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATGVGSNQITFGRGSSQPNLSTSYSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLR----RGDDLRLQMALEESRRD 258

[Close]

BLAST of Epsin 2 vs. Ensembl Mouse
Match: Epn2 (epsin 2 [Source:MGI Symbol;Acc:MGI:1333766])

HSP 1 Score: 229.95 bits (585), Expect = 2.528e-65
Identity = 117/257 (45.53%), Postives = 168/257 (65.37%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQ------HRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE 825
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +  AF +IM ++WKRLND GKNWRHVYK+L LLDYL+K G+ER+A++C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD+E L  ER + LK KE+     + +GS+Q        +P        +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+++
Sbjct:    6 IRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATGVGSNQITFGRGSSQPNLSTSYSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLR----RGDDLRLQMALEESRRD 258

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BLAST of Epsin 2 vs. UniProt/SwissProt
Match: sp|Q80VP1|EPN1_MOUSE (Epsin-1 OS=Mus musculus OX=10090 GN=Epn1 PE=1 SV=3)

HSP 1 Score: 236.884 bits (603), Expect = 5.573e-67
Identity = 141/376 (37.50%), Postives = 208/376 (55.32%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI--------EDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE----EEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPL-----DFDPWKSPDNNFGSSKTPM--NTSTPDVWLNKD 1170
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER++++C +N++ ++TLKDFQY + + KD GV +REK+K LV LL+D++ L  ER+  LK KEK     ++  +     P     +   Q + + +     ++L    +K E         EDD +LQ A+ LS+EEH++  +IR    R ++L++++A+E+SK+E    EE    +   +     PP+ SD       +  +    +           D   G      V   +DPWG  A    S D   P        DPW       G +  P      TPD W + D
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEEL---QLQLALAMSKEEADQPPSCGPEDDVQLQLALSLSREEHDKEERIR----RGDDLRLQMAIEESKRETGGKEESSLMDLADVFTTPAPPQASDPWGGPASVPTAVPVAAAAS--------DPWGGPA----VPPAADPWGGAAPTPASGDPWRPAAPTGPSVDPW-------GGTPAPAAGEGPTPDPWGSSD 355

[Close]

BLAST of Epsin 2 vs. UniProt/SwissProt
Match: sp|Q9Z1Z3|EPN2_RAT (Epsin-2 OS=Rattus norvegicus OX=10116 GN=Epn2 PE=1 SV=1)

HSP 1 Score: 230.335 bits (586), Expect = 1.578e-64
Identity = 135/355 (38.03%), Postives = 196/355 (55.21%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQ------HRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQD------SSIPLDFDPWKSP 1101
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +   F +IM ++WKRLND GKNWRHVYK+L LLDYL+K G+ER+A++C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD+E L  ER + LK KE+     + +GS+Q        +P        +++ K    P +          SE+E            +LQ A+ +S+E  E+  ++R    R ++L++++ALE+S+++       ++V A  +P           TLL        L     +S    Q+    S+     +++PWG T       D      +      DPW  P
Sbjct:    6 IRRQMKNIVNSYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVRFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATGVGSNQITFGRGSSQPNLSISHSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLR----RGDDLRLQMALEESRRDTVKVPKKKEVKACCKP----GSHSQQTTLL-------DLMDALPSSGPVAQKTEPWSTGTPANQTNPWGGTVAPANISDPWPSFGTKPAASVDPWGVP 345

[Close]

BLAST of Epsin 2 vs. UniProt/SwissProt
Match: sp|Q9Y6I3|EPN1_HUMAN (Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2)

HSP 1 Score: 229.95 bits (585), Expect = 1.820e-64
Identity = 142/378 (37.57%), Postives = 205/378 (54.23%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI--------EDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSK-----KEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPL-----DFDPWKSPDNNFGSSKTPM--NTSTPDVWLNKDS 1173
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER++++C +N++ ++TLKDFQY + + KD GV +REK+K LV LL+D++ L  ER+  LK KEK     ++  +     P     +   Q + + +     ++L    +K E         EDD +LQ A+ LS+EEH++  +IR    R ++L++++A+E+SK     KEE    +   V     P P         T             +  A+   D   G      V   +DPWG  A    S D   P        DPW       G +  P      TPD W + D 
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEEL---QLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIR----RGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAP---------TTDPWGGPAPMAAAVPTAAPTSDPWGGP----PVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPW-------GGTPAPAAGEGPTPDPWGSSDG 356

[Close]

BLAST of Epsin 2 vs. UniProt/SwissProt
Match: sp|O88339|EPN1_RAT (Epsin-1 OS=Rattus norvegicus OX=10116 GN=Epn1 PE=1 SV=1)

HSP 1 Score: 229.18 bits (583), Expect = 3.222e-64
Identity = 114/250 (45.60%), Postives = 172/250 (68.80%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI--------EDD-ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE 825
            +RR++KN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK++ L++YL+K G+ER++++C +N++ ++TLKDFQY + + KD GV +REK+K LV LL+D++ L  ER+  LK KEK     ++  +     P     +   Q + + +     ++L    +K E         EDD +LQ A+ LS+EEH++  +IR    R ++L++++A+E+SK+E
Sbjct:    6 LRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEEL---QLQLALAMSKEEADQPPSCGPEDDVQLQLALSLSREEHDKEERIR----RGDDLRLQMAIEESKRE 248

[Close]

BLAST of Epsin 2 vs. UniProt/SwissProt
Match: sp|Q8CHU3|EPN2_MOUSE (Epsin-2 OS=Mus musculus OX=10090 GN=Epn2 PE=1 SV=1)

HSP 1 Score: 226.098 bits (575), Expect = 6.926e-63
Identity = 118/265 (44.53%), Postives = 170/265 (64.15%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQ------HRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMK----IRQDEERR----EELKIKLALEQSKKE 825
            IRR++KN+V  YSEAE  VREATSNDPWGPSS+LM+EIAD+T +  AF +IM ++WKRLND GKNWRHVYK+L LLDYL+K G+ER+A++C +NI  I+TLKDFQY + + KD G+ +REKSK LV LLKD+E L  ER + LK KE+     + +GS+Q        +P        +++ K    P +          SE+E            +LQ A+ +S+E  E++ +     R  +E R    ++L++++ALE+S+++
Sbjct:    6 IRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKVERVQALKTKERMAQVATGVGSNQITFGRGSSQPNLSTSYSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQSSESVQTARGSKEERLRRGDDLRLQMALEESRRD 270

[Close]

BLAST of Epsin 2 vs. TrEMBL
Match: V9KJM3 (Epsin-3-like protein OS=Callorhinchus milii OX=7868 GN=epn3 PE=2 SV=1)

HSP 1 Score: 254.603 bits (649), Expect = 9.908e-71
Identity = 215/664 (32.38%), Postives = 336/664 (50.60%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELG----REIRKQFT------KDNQFPRTVMKLNFEE---TKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLA--------VLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWE-ESDSS------FGQLTKNTTGSL-ASLTDIGNDLS-REKKHSCSVTDLLDTNTSTN----------KKKTPQEFX-XXXXXXXXXXXXXPIPKAGVYRDPMSHVAKNPFGMTASAVVS---NPFNNQTINPKIPMNQI----GNSNNSLFASSGNLTSMGINNGQMNSFTTP---MQPTFPISHSQYQGFS--------------TMNNFSNIPWSQPVAPITNQWAI--NTNTANPFF 1893
            IRR+VKN+V+ YSEAE  VREATSNDPWGP S+LMS+IAD+T +  AF +IM ++WKRLND GKNWRHVYK+L LLDYL+K G+E+++++C +NI+T++TLKDFQY + + KD G+ +REK+K LV LLKD+E L  +R+  LK KE+     + +GSHQH  P         + RK         +D+         + E+   T S  E+ +LQ A+ +S+EE ER ++ R   +  EE+++++AL  SK++ E ++  +  L          LR   +  ++   E+ +S+     SL  L +   IF            +  +DPWGA    V +          PW   D +   + +P + ++PD W             D  G E P    A +W   ++  + +  ++  D +PW    D S      +  L   T+GS  A   D+ ++++   K++  S  D+ D     N           ++TP+ FL    A+LVNL++L+ IP       P S  +KNPF +T +A      NPF     N K+ +NQ+    G   +SL  S     ++G+ +G M   ++P   +  + P+S +    FS              T+N  S++P  QP+ P+T    +   +   NPF 
Sbjct:    6 IRRQVKNLVHNYSEAEIKVREATSNDPWGPPSSLMSDIADLTFNVVAFSEIMGMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSEKVSQQCRENIYTVQTLKDFQYIDRDGKDQGINVREKAKQLVSLLKDEERLRQDRAHALKTKERMSQAATGLGSHQHSHPSLASYTHPEDHRKSACASPISYQDSSSSSPRFDPDLEQARPTTSGEEELQLQLALAMSREEAERGLQ-RSPTDSEEEIQLQIALSLSKEQHEKEQRERSSLVDDDEDEDDTLR---RALEESRRESEMSQGKNESSLMDLVD---IFGA-----PVTGPEGHADPWGAELNGVSAPG-------HPWG--DKH---ATSPTSGTSPDPW-------------DSLGTEMPAPAVADSW---MSADSQAASSQPWDPDPWAGPPDPSQSPLDPWASLPTPTSGSQPAGKLDLLSEVAPSSKQNGTSSPDIFDMTGMGNCLQDSAKTNGTRRTPELFLDPNAASLVNLDSLLSIP-------PQSVKSKNPFHVTGAASAPSAINPFQVSDRN-KLTLNQMQISSGLGQDSLTQSG----TVGLASGSMPFMSSPPMALNSSMPVSLTLPPTFSGLAQLGGMAPNMGTTVNMTSSLP--QPLMPVTQPAHVPQASGQLNPFL 615

[Close]

BLAST of Epsin 2 vs. TrEMBL
Match: A0A2A2KJI6 (ENTH domain-containing protein OS=Diploscapter pachys OX=2018661 GN=WR25_00488 PE=4 SV=1)

HSP 1 Score: 250.366 bits (638), Expect = 1.833e-70
Identity = 148/339 (43.66%), Postives = 203/339 (59.88%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDE---LQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNF 1113
            IRR+VKNV Y +S+A+  VREATSNDPWGPS+ LMSEIAD+TN+  AF +IM ++WKRLND GKNWRHVYKSLVLLD+L+KCGNE++A++C +NI TIETLKDFQ+ EE++D G+ IREK+K +V LL D+E L NER++ +  + KF+    S  S      G  G   R +   D+      +   FEE +   + +E   LQ A+ LS+EEHE+  ++R    + +E++++LALE+S+KE E            +P   V   Q     LS+SA  D L  L     + +    D  S      S  WG    N  +  SS+    DPW +P   F
Sbjct:    6 IRRQVKNVAYNFSDAQVKVREATSNDPWGPSTALMSEIADLTNNPMAFTEIMSIVWKRLNDSGKNWRHVYKSLVLLDFLIKCGNEKVAQQCRENIFTIETLKDFQHIEENRDQGLNIREKAKQIVSLLSDEERLKNERTRFMLTRNKFKQNYPSSYSDSVGAVGSSGSRHRSRI--DHPTSGASLDPEFEEARPANQTEEEMQLQIALALSREEHEKMDEMR----KSDEVRLQLALEESRKEAE--------KMATQPQGTVHSGQ-----LSQSA-LDDLLSLG-VGELINNTPADQPS------SSAWG---NNSNAGSSSMGGLIDPWATPTQPF 314

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BLAST of Epsin 2 vs. TrEMBL
Match: A0A1I7TMY2 (ENTH domain-containing protein OS=Caenorhabditis tropicalis OX=1561998 PE=4 SV=1)

HSP 1 Score: 247.284 bits (630), Expect = 1.293e-69
Identity = 140/335 (41.79%), Postives = 205/335 (61.19%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEI---EDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVK-SQDSSIPLDFDPWKS 1098
            IRR+VKNV Y +S+A+  VREATSNDPWGPS+ LMSEIAD+T++  AF +IM ++WKRLND GKNWRHVYKSLVLLD+L+KCG+E++A++C +N+ TIETLKDFQ+ E+++D G+ IREK+K +  LL D E L NER++ +  + KF          +   PG +G E R+  +  +    T +   +EE +      E+ +LQ A+ LS+EE E+A ++R+ ++ R    +++ALE+S+K +E DR     LA  +    VS  Q  ++ L      D L  L     +    +   SS   +  +DPWG   ++ + S D       DPW S
Sbjct:    6 IRRQVKNVAYNFSDAQVKVREATSNDPWGPSTALMSEIADLTHNPMAFTEIMSIVWKRLNDSGKNWRHVYKSLVLLDFLIKCGHEKVAQQCRENVFTIETLKDFQHVEDNRDQGLNIREKAKQITSLLSDDERLKNERTRFILTRNKF----------KQNNPGAVGAESRR--SNRHHVSDTSLDPEYEEARPSTATEEEMQLQIALALSREECEKADEMRKSDDAR----LQMALEESQKLQEADR-----LATTK-QGTVSSGQLTQSAL------DDLLSLGVGELVSGNSDQPSSSTAWNNMADPWGVPQSSAQHSNDQMFSSTNDPWAS 312

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BLAST of Epsin 2 vs. TrEMBL
Match: A0A0P4WAE4 (ENTH domain-containing protein OS=Scylla olivacea OX=85551 PE=4 SV=1)

HSP 1 Score: 248.825 bits (634), Expect = 1.333e-68
Identity = 181/510 (35.49%), Postives = 261/510 (51.18%), Query Frame = 1

Query:   94 LQME---IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIE--------DDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDR-NNQKVLAVLRPPPKVS-----DKQNNETLLSKSAKRDSL------YKLSEASRIFDQ--QNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWE-------ESDSSFGQLTKNTTGSLASLTDIGNDLSREKKH-------------SCSVTDLLDTNTS---TNKKKTPQEF 1479
            LQM    IRR +KN+ + Y++A+  VREATSNDPWGPSSTLMSE+AD+T +  AF +IMQ+IWKRLND G+NWRHVYK+LVLL+YL+K G+E++A++C +NI  IETLKDFQYFEE+KD G+ +REK+KALV LLKD+E L NER + LK KE+F    S IGS                F      P        ++  SE+E        ++ELQ  ++L+    +   +  + ++R +++++++A+ QS  EE+F+  N         PP  V+        +N T  + SA             L++A+R  D    NG++    +D  +DPWG    N  S+  + P   DPW SP +   S  T  +  T D W    +R  +  +  I G++           + V G  P  +      +PWE        S   F  LT      +   T +    +REK               S SVTD+  T+T+     K K+P  F
Sbjct:    3 LQMNVSGIRRNLKNIAHNYTDAQIKVREATSNDPWGPSSTLMSEVADLTYNVVAFTEIMQMIWKRLNDHGRNWRHVYKALVLLEYLIKTGSEKVADQCKENIFAIETLKDFQYFEENKDQGMNVREKAKALVTLLKDEERLRNERVRALKAKERFAQSVSGIGSDSDIS-SPTSPTYHDTFVTSTSRPSERNAFGIKDGPSELEAARPQTVGEEELQ--LQLALAMSKEEAEQEEQKKRSDDVRLQMAITQS--EEDFNGVNGGGARPASTPPSTVTLDPWGMPTSNATASATSASPQHTAHIKQNLNLAQATRSLDDLFSNGNI----MDGLTDPWGMALPNGGSETPNQP---DPWGSPVSGPPSRMT--SPPTTDPW--APARSPEPPMGGICGNDP----------WAVLGSVPPAK------DPWEPVENKPPPSRDPFSPLTPTDNRDMDEFTALS---TREKPTNNGSSDAFDLSGLSASVTDITSTSTTKAPPQKSKSPAAF 477

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BLAST of Epsin 2 vs. TrEMBL
Match: A0A267GT68 (ENTH domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig003183g1 PE=4 SV=1)

HSP 1 Score: 245.358 bits (625), Expect = 4.164e-68
Identity = 152/375 (40.53%), Postives = 198/375 (52.80%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELG-REIRKQFTKD--NQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDS----RQSKNIVDDIFG 1209
            IRR +KNVV+ YS+A+  VREATSNDPWGPSSTLM+EIA+MT +  A+ +IM LIWKRLNDK KNWRHVYK+LVLLDYLVK G+E++A++C +N+  I++L+DFQY EE KD G  +REK+K LV LLKD E L  ER+  L+ +E+        G       G    R    ++  D      R              ED EL+ A+ +SKEEH   +K R+ E  +E+LK+K+ALE SKKEEE DR                          KS     L  L + S      NG           DPWGA A  + +   S     DPW +P  +  S+    N +  D W    +    +      DD FG
Sbjct:    4 IRRNIKNVVHNYSDAKVKVREATSNDPWGPSSTLMAEIAEMTYNVMAYTEIMSLIWKRLNDKNKNWRHVYKALVLLDYLVKTGSEKVAQQCKENLFVIQSLRDFQYTEEAKDYGQNVREKAKQLVALLKDDEKLRTERASALRTRERLHASGMIGGGRPTVSSGATAYRRASAEYASDRTGSSVRGAPGGGGGGGGVGEEDVELELALAISKEEHAEELKRREAEGLKEDLKLKMALEASKKEEE-DRK-------------------------KSVSSGGLVDLIDTSLSAAPSNG----------RDPWGAPAAPLAASAWS-----DPWSAPHESASSAAPVSNPTASDPWAFSATPSQPQAGGGTFDDAFG 337

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BLAST of Epsin 2 vs. Ensembl Cavefish
Match: epn1 (epsin-1-like [Source:NCBI gene;Acc:103024066])

HSP 1 Score: 228.409 bits (581), Expect = 2.262e-64
Identity = 120/242 (49.59%), Postives = 169/242 (69.83%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEE 828
            +RR+VKN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM ++WKRLND GKNWRHVYK++ L++YL+K G+ER+A++C +NI+ ++TLKDFQY + + KD GV +REK+K LV LLKD+E L  ER   LK KEK    Q+S  S     PG  G  +      D  +P++          S  ED +LQ A+ +SKEE E+  ++R    R ++L++++A+E+SK+E+
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVAQQCRENIYAVQTLKDFQYIDRDGKDQGVNVREKAKQLVTLLKDEERLREERIHALKTKEKM--AQTSSASSAPSAPGLGG--VSSSTDGDQAWPQS----------SGEEDLQLQLALAMSKEEAEQEERLR----RGDDLRLQMAIEESKREK 229

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BLAST of Epsin 2 vs. Ensembl Cavefish
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 222.246 bits (565), Expect = 5.713e-63
Identity = 116/244 (47.54%), Postives = 157/244 (64.34%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRT-VMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEE 831
            IRR++KNVV  YSEAEK VREATSNDPWGPSS+LMSEI+D+T +  AF +IM +IWKRLND GKNWRHVYK+L LLDYL+K G+ER+A +C +NI  I+TLKDFQY + + KD G+ +REKSK LV+LLKD + L  ERS+ LK KE+     +S+GS+     G    +     +   ++ R+     ++  + S     EL++A              R      EEL+++LAL  S++  E
Sbjct:    6 IRRQMKNVVNNYSEAEKKVREATSNDPWGPSSSLMSEISDLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVVLLKDDDRLKGERSQALKTKERMAQVATSVGSNHQINFGRGSSQPNLSTSYSEEYGRSEGSPASYHGSTSPNASSELEQA--------------RPQTSGEEELQLQLALAMSREAAE 235

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BLAST of Epsin 2 vs. Ensembl Cavefish
Match: epn3b (epsin-3-like [Source:NCBI gene;Acc:103023012])

HSP 1 Score: 216.083 bits (549), Expect = 2.593e-60
Identity = 140/378 (37.04%), Postives = 202/378 (53.44%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIE-----LSKEEHERAMKIRQDEER---REELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSK---SAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQD---------SSIPLDFDPWK------SPDNNFGSSKTPMNTSTPDVW 1158
            +RR+VKN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T S  AF ++M ++WKRLND GKNWRHVYK+L LLDYL K G+ER+A++C +N  TI+TL+DFQY + + +D GV +REK+K LV LL+D+E L  ER++ LK KE+        G                       +P    + + + + + +  +E  R+ E      S     RA ++ Q   +    EEL+++LAL  S++E+                     +Q ++T L K    ++R+S     E+S + D  +    S +     DPW A  T   + D         SS P+   PW       SP + +G+S+TP     PD W
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTFSVVAFSEVMAMVWKRLNDHGKNWRHVYKALTLLDYLAKTGSERVAQQCRENAFTIQTLRDFQYVDRDGRDQGVNVREKAKQLVALLRDEERLRQERAQALKTKERMAGGGGGGGG----------GGGGTGGGGGGAYPS---RRSSQPSMAALYGEEFSRSRESPSSFNSSASSPRASELEQSRPQTSGEEELQLQLALAMSREEQR-------------------SRQGDDTHLQKVLEQSRRESESGQGESS-MLDLVDIFGPSTEAPPSDDPWDAQPTCPMTSDPWETVAVVKSSTPVVGSPWTARPSSGSPSHPWGNSQTP-----PDPW 345

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BLAST of Epsin 2 vs. Ensembl Cavefish
Match: epn3a (epsin 3 [Source:NCBI gene;Acc:103029089])

HSP 1 Score: 207.223 bits (526), Expect = 5.401e-57
Identity = 132/383 (34.46%), Postives = 201/383 (52.48%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRT--------------VMKLNFEETKSEIEDDE---LQRAIELSKEEHERAMKIRQDEERR------------------EELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSS---------IPLDFDPWKSPDNNFGS 1119
            +RR VKN+V  Y+EAE  VREATSNDPWGP S+LM EIAD+T +  AF ++M ++WKRLND GKNWRHVYK+L LL+YL+K G+ER+A++C +NI+ I+TL+DFQY + + +D GV +REK+K LV LL+D++ L  ERS+  K +E+      + GS     PG+            +++ R+               +  + E+ + +   +E   LQ A+ +S+EE E   K+R  + R                   E+ ++++AL  SK+E + ++ +               +Q +E+LL K+        L E+ R  + + G  + LD+     P       V   D S          PL  DPW S D +  S
Sbjct:    6 LRRSVKNIVNNYTEAEIKVREATSNDPWGPPSSLMMEIADLTFNVVAFTEVMGMVWKRLNDHGKNWRHVYKALTLLEYLLKAGSERVAQQCRENIYAIQTLRDFQYIDRDGQDQGVNVREKAKQLVSLLRDEDRLKQERSQAHKTRERMAG---AYGSLPPPYPGQRTSHATAATMHGDEYRRSRGSPSSHTSSSSSPHLAPDLEQARPQTSGEEELQLQLALAMSREESE---KVRIPDSRATTTPVKKVPPPSVALDMDEDTQLQIALSLSKEEHQQEQRS---------------RQGDESLLQKA--------LEESKREMEAKGGGSAMLDLVDIFAPAPEAPPGVSPWDLSGAGAQAQAAGPLRSDPWDSLDPSSSS 359

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BLAST of Epsin 2 vs. Ensembl Cavefish
Match: epn3a (epsin 3 [Source:NCBI gene;Acc:103029089])

HSP 1 Score: 205.682 bits (522), Expect = 2.642e-56
Identity = 137/403 (34.00%), Postives = 206/403 (51.12%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRT--------------VMKLNFEETKSEIEDDE---LQRAIELSKEEHERAMKIRQDEERR-------------EELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVS-------------------------DKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSS---------IPLDFDPWKSPDNNFGS 1119
            +RR VKN+V  Y+EAE  VREATSNDPWGP S+LM EIAD+T +  AF ++M ++WKRLND GKNWRHVYK+L LL+YL+K G+ER+A++C +NI+ I+TL+DFQY + + +D GV +REK+K LV LL+D++ L  ERS+  K +E+      + GS     PG+            +++ R+               +  + E+ + +   +E   LQ A+ +S+EE E   K+R  + R              E+ ++++A+  SK+E +     +KV     PPP V+                          +Q +E+LL K+        L E+ R  + + G  + LD+     P       V   D S          PL  DPW S D +  S
Sbjct:    6 LRRSVKNIVNNYTEAEIKVREATSNDPWGPPSSLMMEIADLTFNVVAFTEVMGMVWKRLNDHGKNWRHVYKALTLLEYLLKAGSERVAQQCRENIYAIQTLRDFQYIDRDGQDQGVNVREKAKQLVSLLRDEDRLKQERSQAHKTRERMAG---AYGSLPPPYPGQRTSHATAATMHGDEYRRSRGSPSSHTSSSSSPHLAPDLEQARPQTSGEEELQLQLALAMSREESE---KVRIPDSRATTTPVKPPPVDVDEQTQLQIAMSLSKEESQ-----KKV-----PPPSVALDMDEDTQLQIALSLSKEEHQQEQRSRQGDESLLQKA--------LEESKREMEAKGGGSAMLDLVDIFAPAPEAPPGVSPWDLSGAGAQAQAAGPLRSDPWDSLDPSSSS 384

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BLAST of Epsin 2 vs. Ensembl Sea Lamprey
Match: epn2 (epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1])

HSP 1 Score: 231.106 bits (588), Expect = 1.759e-66
Identity = 136/346 (39.31%), Postives = 194/346 (56.07%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGE------LGREIRKQFTKDNQFPRTV-------MKLNFEETKSEIEDDE---LQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPW 1092
            +RR++KN+V  +SEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM +IWKRLND GKNWRHVYK+L LLDYL+K G+ER+A++C +NI  I+TLKDFQY + + KD GV +REKSK LV LL+D++ L  ER   LK KE+     + +GS+     G       L      ++ K    P +        M    E+ + +   +E   LQ A+ +S+EE E+  ++R    R ++L++++ALE+SK+                   K++ K+  E    + +++ SL  L +A R    Q            +DPWG T           P   DPW
Sbjct:    6 LRRQMKNIVNNFSEAEVKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCKENIFAIQTLKDFQYVDRDGKDQGVNVREKSKQLVALLRDEDRLRGEREHALKTKERLAQGATGMGSNNKVTFGRGSSQPNLSTSYSDEYGKAGGSPASYHGYTSQHMSTQLEQARPQTSGEEELQLQLALAMSREEAEQEERMR----RGDDLRLQMALEESKRA------------------KLAAKK-EEVCACRHSRQSSLLDLVDAFRPTVPQ----------PSADPWGVTPPP--------PAQADPW 310

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BLAST of Epsin 2 vs. Ensembl Sea Lamprey
Match: clint1a (clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-030131-2590])

HSP 1 Score: 108.612 bits (270), Expect = 1.178e-24
Identity = 57/144 (39.58%), Postives = 93/144 (64.58%), Query Frame = 1

Query:  124 NVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKR-LNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEH-KDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKF 549
            N+V  Y+E E  VREAT+++PWGPS  LM EIA  T  Y  F ++M ++W R L +   NWR  YK L+LL YL++ G+ER+     ++++ + +L+D+ + +E+ KD GV +R+K K ++  ++D E +  ER K  K ++K+
Sbjct:   15 NIVMNYTEMEAKVREATNDEPWGPSGKLMGEIAKATFMYELFPEVMNMLWARMLRENKNNWRRAYKGLLLLTYLLRNGSERVVTSAREHLYDLRSLEDYHFVDENGKDQGVNVRQKVKEMIDFVQDDERVREERKKAKKHRDKY 158

[Close]

BLAST of Epsin 2 vs. Ensembl Yeast
Match: ENT3 (Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p [Source:SGD;Acc:S000003886])

HSP 1 Score: 126.331 bits (316), Expect = 1.345e-31
Identity = 61/149 (40.94%), Postives = 98/149 (65.77%), Query Frame = 1

Query:  112 RKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDK-GKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQ 552
            RK +NVV+ Y+E E  VREAT+N+PWG SSTLM +I+  T ++   ++I+ +I++R  +K G  WR +YK+L LLDYL+K G+ER  ++   +I+ I  L+ F Y + + +D G+ +R + KAL+ LL D   +  ER K  +  +K++
Sbjct:   20 RKAQNVVFNYTEMEGKVREATNNEPWGASSTLMDQISQGTYNFREREEILSMIFRRFTEKAGSEWRQIYKALQLLDYLIKHGSERFIDDTRNSINLIRILETFHYIDSQGRDQGINVRTRVKALIELLSDDNKIRAERKKARETAKKYK 168

[Close]

BLAST of Epsin 2 vs. Ensembl Yeast
Match: ENT2 (Epsin-like protein required for endocytosis and actin patch assembly; functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus; ENT2 has a paralog, ENT1, that arose from the whole genome duplication [Source:SGD;Acc:S000004196])

HSP 1 Score: 111.309 bits (277), Expect = 7.291e-26
Identity = 62/138 (44.93%), Postives = 86/138 (62.32%), Query Frame = 1

Query:  112 RKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHK-DLGVGIREKSKALVILLKDKEILTNERS 522
            R  KN++  YS  +  VR+AT+ND   PS   + ++A  +     F +IM ++ KRLNDKGK WRHV KSL +LDYLV+ G+E     C +N + I+TL++F++  E   D G  IR K+K LV LL D+E L  ERS
Sbjct:    7 RSAKNMMKGYSSTQVLVRDATANDSRTPSIDTLDDLAQRSYDSVDFFEIMDMLDKRLNDKGKYWRHVAKSLTVLDYLVRFGSENCVLWCRENFYVIKTLREFRHENESGFDEGQIIRVKAKELVSLLNDEERLREERS 144

[Close]

BLAST of Epsin 2 vs. Ensembl Yeast
Match: ENT1 (Epsin-like protein involved in endocytosis and actin patch assembly; functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus; relocalizes from bud neck to cytoplasm upon DNA replication stress; ENT1 has a paralog, ENT2, that arose from the whole genome duplication [Source:SGD;Acc:S000002320])

HSP 1 Score: 108.227 bits (269), Expect = 2.727e-25
Identity = 84/247 (34.01%), Postives = 125/247 (50.61%), Query Frame = 1

Query:  112 RKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYF-EEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAI---ELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDR 840
            R  KN+V  YS  +  VR ATSND    S   + E+A+ +   + F +IM ++ KRLNDKGK WRH+ K+L ++DYL++ G+E     C +N++ I+TLK+F++  +E  D G  +R K+K L  LL D E L  ER+  +K + +   ++                                        +S+  DD+LQRAI    L+ EE ER  K  QDE+       + AL+ SK+EEE  R
Sbjct:    7 RSAKNLVKGYSSTQVLVRNATSNDNHQVSKDSLIELAEKSYDSADFFEIMDMLDKRLNDKGKYWRHIAKALTVIDYLIRFGSENCVLWCRENLYIIKTLKEFRHEDDEGIDQGQIVRVKAKELTALLSDDERLNEERNMNIKGRNRKGRRRRG------------------------------------TGRSDENDDDLQRAISASRLTAEEDERRRK--QDED------YETALQLSKEEEELKR 209

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BLAST of Epsin 2 vs. Ensembl Yeast
Match: ENT4 (Protein of unknown function; contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome [Source:SGD;Acc:S000003961])

HSP 1 Score: 52.373 bits (124), Expect = 7.570e-8
Identity = 35/103 (33.98%), Postives = 55/103 (53.40%), Query Frame = 1

Query:  133 YKYSEAEKYVREATSND-PWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRL------NDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQ 420
            +  S  E  V++AT+ D   G + TLM+EI+ +T S     +I+Q+I KRL       +  +N   V K+L L+ YL+  G+    +    N+  IE L+DFQ
Sbjct:   10 FIQSPTESKVKQATNEDETSGATGTLMNEISILTYSPKTVREIIQVIRKRLLLGQNRRNSHRNCIQVMKTLTLVSYLMNNGSNEFIKWLKGNMILIEILEDFQ 112

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BLAST of Epsin 2 vs. Ensembl Yeast
Match: ENT5 (Protein containing an N-terminal epsin-like domain; involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin [Source:SGD;Acc:S000002560])

HSP 1 Score: 50.0618 bits (118), Expect = 9.900e-7
Identity = 51/187 (27.27%), Postives = 84/187 (44.92%), Query Frame = 1

Query:  112 RKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIM-QLIWKRLNDK-------------------GKNWRHVYKSLVLLDYL---VKCGNE-RIAEECLQNIHTIETLKDFQY---FEEHKDLGV---GIREKSKALVILLKDKEILTNERSK----GLKVKEKFQNKQSSI 570
            R  +NV+ +Y   +  +R AT+ D WGP+   ++++  + N Y     +M +   KRL D                    G  WR V K LV++++L   V  G+E      CL     I T +  Q+   F     + +   GIR+K + ++  L+D + L  ER+K     LK++   Q  +SSI
Sbjct:   21 RFAQNVIVQYEPYQIDIRRATNTDAWGPTPKHLAKV--LRNRYQVPLYLMTEYTLKRLVDHIATRPKNLYEKARKDYVNYGSEWRVVLKCLVVIEFLLLNVDTGDELNQIRSCLLTHKHILTREIAQFKVKFSNDGKMEIHERGIRKKGELILQYLEDSQFLKKERAKNKKNALKIR---QQGESSI 202

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BLAST of Epsin 2 vs. Ensembl Nematostella
Match: EDO36992 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SH59])

HSP 1 Score: 205.297 bits (521), Expect = 5.899e-62
Identity = 97/156 (62.18%), Postives = 123/156 (78.85%), Query Frame = 1

Query:  100 MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQS 564
            M IRR++KNVV  YS +E  VREATSNDPWGPSS+LMSEIAD T +  AF +IM +IW+RLND GKNWRHVYKSLVLLDY++K G+ER+A++C +NI  I+TLKDFQ+ + + KD G+ +REK+K LV LLKD+E L +ER + LK KE+F    S
Sbjct:    1 MSIRRQLKNVVNNYSNSEVKVREATSNDPWGPSSSLMSEIADATYNVVAFSEIMAMIWRRLNDHGKNWRHVYKSLVLLDYIIKTGSERVAQQCRENIFVIQTLKDFQFIDKDGKDQGMNVREKAKQLVALLKDEERLKSERQRALKAKERFAQASS 156

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BLAST of Epsin 2 vs. Ensembl Nematostella
Match: EDO48788 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIC8])

HSP 1 Score: 110.153 bits (274), Expect = 8.097e-28
Identity = 64/151 (42.38%), Postives = 99/151 (65.56%), Query Frame = 1

Query:  103 EIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKR-LNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEH-KDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKF 549
            EI  KV NVV  YSE E  VREAT++D WGP  +LM EIA  T +Y  F ++M ++WKR L +  K WR +YKSL+LL YL+K G++R+      +I+ +  L++F + +E+ KD G+ +R K K L+ L++D + + +ER +  K ++K+
Sbjct:    9 EISDKVTNVVMNYSEVEAKVREATNDDTWGPHGSLMQEIAKYTFTYEHFPEVMSMLWKRMLQEPKKYWRRIYKSLLLLGYLLKNGSDRVVTNARDHIYDMRQLENFHHTDENGKDQGINVRHKVKELIELVQDDDRIRSERKRAKKNRDKY 159

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BLAST of Epsin 2 vs. Ensembl Medaka
Match: epn2 (epsin 2 [Source:NCBI gene;Acc:101161060])

HSP 1 Score: 232.646 bits (592), Expect = 1.920e-66
Identity = 125/257 (48.64%), Postives = 170/257 (66.15%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQ------HRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDD----------ELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKE 825
            IRR++KN+V  YS+AEK VREATSNDPWGPSS+LMSE+AD+T +  AF +IM +IWKRLND GKNWRHVYK+L LLDYL+K G+ER+A +C +NI  I+TLKDFQY + + KD G+ +REKSK LV+LLKD+E L  ERS+ LK KE+    Q S GS Q        +P  L     +++ +    P +          SE+E            +LQ A+ +S+E  E+  +IR    R ++L++++ALE+SKKE
Sbjct:    5 IRRQMKNMVNNYSDAEKKVREATSNDPWGPSSSLMSEVADLTYNVVAFSEIMNMIWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVALQCKENIFAIQTLKDFQYVDRDGKDQGINVREKSKQLVVLLKDEERLKAERSQALKTKERM--AQVSTGSSQMGFGRGSSQP-NLSTSYSEEYGRSEGSPASYHGSTSPNAGSELEQARPQTSGEEELQLQLALAMSREAAEQEERIR----RGDDLRLQMALEESKKE 254

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BLAST of Epsin 2 vs. Ensembl Medaka
Match: epn1 (epsin-1 [Source:NCBI gene;Acc:101167232])

HSP 1 Score: 233.032 bits (593), Expect = 6.260e-66
Identity = 140/363 (38.57%), Postives = 198/363 (54.55%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQ--FPRTV------MKLNFEETKSE--------IEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEE------------EFDRNNQKVLAVLR-----PPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPW 1092
            +RR+VKN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM ++WKRLND GKNWRHVYK++ L++YL+K G+ER+A++C +NI+ ++TLKDFQY + + KD G+ +REK+K LV LLKD+E L  ER   LK KEK     S+  +      G            D +  +P++       ++L    +K E        +ED EL  AI LSKE H++  ++R    R ++L++++A+E+SKKE+              D       A +      PPP V     +    + +A  D     S  S       G      V    DPWG T+  V         + DPW
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVAQQCRENIYAVQTLKDFQYIDRDGKDQGLNVREKAKQLVTLLKDEEKLREERIHALKTKEKMAQTSSASSAPSAPSLGGSLSLGSHSGGADPEQAWPQSSGEEDLQLQLALAMSKEEAEQTSTDPLEDAELHYAITLSKEIHQKEERLR----RGDDLRLQMAIEESKKEKPKPEESALMELSAVDPWGAPATATVASAGPSPPPTVPGSAASNPW-APAASTDPWGVTSPTSPTSSDPWGGGPQPTVAPPPDPWGETSNKVN--------NVDPW 355

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BLAST of Epsin 2 vs. Ensembl Medaka
Match: epn1 (epsin-1 [Source:NCBI gene;Acc:101167232])

HSP 1 Score: 230.72 bits (587), Expect = 2.616e-65
Identity = 136/347 (39.19%), Postives = 192/347 (55.33%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEE------------EFDRNNQKVLAVLR-----PPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPW 1092
            +RR+VKN+V+ YSEAE  VREATSNDPWGPSS+LMSEIAD+T +  AF +IM ++WKRLND GKNWRHVYK++ L++YL+K G+ER+A++C +NI+ ++TLKDFQY + + KD G+ +REK+K LV LLKD+E L  ER   LK KEK     S+  +      G            D +         + ++  E ED +LQ A+ +SKEE E+  ++R    R ++L++++A+E+SKKE+              D       A +      PPP V     +    + +A  D     S  S       G      V    DPWG T+  V         + DPW
Sbjct:    6 LRRQVKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVAQQCRENIYAVQTLKDFQYIDRDGKDQGLNVREKAKQLVTLLKDEEKLREERIHALKTKEKMAQTSSASSAPSAPSLGGSLSLGSHSGGADPE-------QAWPQSSGE-EDLQLQLALAMSKEEAEQEERLR----RGDDLRLQMAIEESKKEKPKPEESALMELSAVDPWGAPATATVASAGPSPPPTVPGSAASNPW-APAASTDPWGVTSPTSPTSSDPWGGGPQPTVAPPPDPWGETSNKVN--------NVDPW 331

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BLAST of Epsin 2 vs. Ensembl Medaka
Match: epn3a (epsin-1 [Source:NCBI gene;Acc:101168623])

HSP 1 Score: 196.052 bits (497), Expect = 3.334e-53
Identity = 102/219 (46.58%), Postives = 137/219 (62.56%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKI 759
            IRR++KN V+ Y++AE  VREAT NDPWGP  +LMSEI+D+T +  AF DIM++IWKRLND GKNWRHV+K+LVLL++LVK G+ER+ + C +NIH+I+TLKDFQY + +  D G  +REK+K L  LL+D+E L  ERS  LK K +     S +                        +P T  +L      SEIE     +A+  S EE ER +K+
Sbjct:    6 IRRQMKNAVHSYTDAEIKVREATCNDPWGPPVSLMSEISDLTFNVVAFADIMRIIWKRLNDNGKNWRHVFKALVLLEHLVKTGSERVVKACKENIHSIQTLKDFQYIDRDGHDQGATVREKAKRLASLLRDEEKLKKERSHALKSKSRVAGLPSPLDRSMSSS--------SFDSDLPPSYPSTPSRL-----PSEIE-----KALPTSAEEEERQLKL 206

[Close]

BLAST of Epsin 2 vs. Ensembl Medaka
Match: epn3a (epsin-1 [Source:NCBI gene;Acc:101168623])

HSP 1 Score: 196.052 bits (497), Expect = 4.018e-53
Identity = 102/219 (46.58%), Postives = 137/219 (62.56%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFE-EHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKI 759
            IRR++KN V+ Y++AE  VREAT NDPWGP  +LMSEI+D+T +  AF DIM++IWKRLND GKNWRHV+K+LVLL++LVK G+ER+ + C +NIH+I+TLKDFQY + +  D G  +REK+K L  LL+D+E L  ERS  LK K +     S +                        +P T  +L      SEIE     +A+  S EE ER +K+
Sbjct:    6 IRRQMKNAVHSYTDAEIKVREATCNDPWGPPVSLMSEISDLTFNVVAFADIMRIIWKRLNDNGKNWRHVFKALVLLEHLVKTGSERVVKACKENIHSIQTLKDFQYIDRDGHDQGATVREKAKRLASLLRDEEKLKKERSHALKSKSRVAGLPSPLDRSMSSS--------SFDSDLPPSYPSTPSRL-----PSEIE-----KALPTSAEEEERQLKL 206

[Close]

BLAST of Epsin 2 vs. Planmine SMEST
Match: SMESG000042233.1 (SMESG000042233.1)

HSP 1 Score: 1182.16 bits (3057), Expect = 0.000e+0
Identity = 592/599 (98.83%), Postives = 592/599 (98.83%), Query Frame = 1

Query:  100 MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTSTNKKKTPQEFXXXXXXXXXXXXXXPIPKAGVYRDPMSHVAKNPFGMTASAVVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTPMQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN 1896
            MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEE       VLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTSTNKKKTPQEFLGENANLVNLENLVPIPKAGVYRDPMSHVAKNPFGMTASAVVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTPMQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN
Sbjct:    1 MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEE-------VLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTSTNKKKTPQEFLGENANLVNLENLVPIPKAGVYRDPMSHVAKNPFGMTASAVVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTPMQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN 592

[Close]

BLAST of Epsin 2 vs. Planmine SMEST
Match: SMESG000042233.1 (SMESG000042233.1)

HSP 1 Score: 1153.27 bits (2982), Expect = 0.000e+0
Identity = 583/599 (97.33%), Postives = 583/599 (97.33%), Query Frame = 1

Query:  100 MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTSTNKKKTPQEFXXXXXXXXXXXXXXPIPKAGVYRDPMSHVAKNPFGMTASAVVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTPMQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN 1896
            MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEE       VLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTSTNKKKTPQEFLGENANLVNLENLVPIPKA         VAKNPFGMTASAVVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTPMQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN
Sbjct:    1 MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEE-------VLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTSTNKKKTPQEFLGENANLVNLENLVPIPKA---------VAKNPFGMTASAVVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTPMQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN 583

[Close]

BLAST of Epsin 2 vs. Planmine SMEST
Match: SMESG000042233.1 (SMESG000042233.1)

HSP 1 Score: 1084.71 bits (2804), Expect = 0.000e+0
Identity = 554/599 (92.49%), Postives = 554/599 (92.49%), Query Frame = 1

Query:  100 MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQKVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTSTNKKKTPQEFXXXXXXXXXXXXXXPIPKAGVYRDPMSHVAKNPFGMTASAVVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTPMQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN 1896
            MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEE                                    LYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTSTNKKKTPQEFLGENANLVNLENLVPIPKA         VAKNPFGMTASAVVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTPMQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN
Sbjct:    1 MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEE------------------------------------LYKLSEASRIFDQQNGDLSSLDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTPDVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDSNPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTSTNKKKTPQEFLGENANLVNLENLVPIPKA---------VAKNPFGMTASAVVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTPMQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN 554

[Close]

BLAST of Epsin 2 vs. Planmine SMEST
Match: SMESG000066105.1 (SMESG000066105.1)

HSP 1 Score: 171.014 bits (432), Expect = 1.750e-45
Identity = 95/248 (38.31%), Postives = 154/248 (62.10%), Query Frame = 1

Query:  106 IRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGSHQHRRPGELGREIRK-----QFTKDNQFPRTVMKLNFE-ETKSEIEDDELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEE 831
            IRRK+KNVV  YSE E  VREATSN+ WGPS++++ +IA ++   +    IM +IWKRL D GK WRHVYKSL+L+++L+  GN  IAE C QN+H +++L++FQY +   DLG  IR++++ +V LLKD ++L +ER+K      +F     S GS+   + G     + +      F  +N+  + ++K ++   T  + ED +LQ A+  S+E+  +  K+ + E+  ++ K+ LA+ ++  E E
Sbjct:    2 IRRKIKNVVKNYSETEILVREATSNESWGPSNSILVKIATLSAVDTNIVQIMPIIWKRLKDSGKKWRHVYKSLILMEFLITRGNPSIAENCRQNVHFLQSLENFQYEDNGVDLGARIRKRAETIVQLLKDSDLLKSERNKAAITDMRFSKAIVSQGSNVPIKYGNGVGSLSQGPSTGSFGSNNE-TKDIIKPDYAVPTSLQEEDIQLQIALAESQEDANQKQKLEKIEQLTDDYKMSLAIRKNLNENE 248

[Close]

BLAST of Epsin 2 vs. Planmine SMEST
Match: SMESG000019746.1 (SMESG000019746.1)

HSP 1 Score: 118.627 bits (296), Expect = 6.458e-28
Identity = 71/170 (41.76%), Postives = 105/170 (61.76%), Query Frame = 1

Query:   91 ELQMEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAFDDIMQLIWKRL-NDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTIETLKDFQYFEEH-KDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKFQNKQSSIGS-HQHRR 591
            E+  E+  KV N V  Y+E E  VR AT++DPWGP    M EIA+ T  Y     +M ++W+R+  ++  NWR  YKSL+LL YL++ G+ERI   C ++I+ +  L+ +QY +E+ KD G+ IR KSK L+ LL+++  L+NER K    + K+  K    GS + HRR
Sbjct:    7 EMGKELADKVTNAVMNYTEVEAKVRAATNDDPWGPHGQDMQEIAEFTKHYDTLTQVMGMLWRRMFQEQKSNWRRTYKSLLLLSYLLRNGSERIVISCKEHIYDLRLLESYQYIDENGKDQGINIRHKSKELIGLLENESQLSNERKKATSNRSKY--KAGISGSVNGHRR 174

The following BLAST results are available for this feature:

BLAST of Epsin 2 vs. Ensembl Human
BLAST of Epsin 2 vs. Ensembl Celegans
BLAST of Epsin 2 vs. Ensembl Fly
BLAST of Epsin 2 vs. Ensembl Zebrafish
BLAST of Epsin 2 vs. Ensembl Xenopus
BLAST of Epsin 2 vs. Ensembl Mouse
BLAST of Epsin 2 vs. UniProt/SwissProt
BLAST of Epsin 2 vs. TrEMBL
BLAST of Epsin 2 vs. Ensembl Cavefish
BLAST of Epsin 2 vs. Ensembl Sea Lamprey
BLAST of Epsin 2 vs. Ensembl Yeast
BLAST of Epsin 2 vs. Ensembl Nematostella
BLAST of Epsin 2 vs. Ensembl Medaka
BLAST of Epsin 2 vs. Planmine SMEST

BLAST of Epsin 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
EPN2	2.617e-66	38.07	epsin 2 [Source:HGNC Symbol;Acc:HGNC:18639]	[more]
EPN2	2.617e-66	38.07	epsin 2 [Source:HGNC Symbol;Acc:HGNC:18639]	[more]
EPN2	3.666e-66	36.99	epsin 2 [Source:HGNC Symbol;Acc:HGNC:18639]	[more]
EPN2	1.898e-65	45.53	epsin 2 [Source:HGNC Symbol;Acc:HGNC:18639]	[more]
EPN1	3.791e-65	37.57	epsin 1 [Source:HGNC Symbol;Acc:HGNC:21604]	[more]

BLAST of Epsin 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
epn-1	4.878e-70	42.49	EPsiN (Endocytic protein) homolog [Source:UniProt...	[more]
epn-1	1.273e-68	42.49	EPsiN (Endocytic protein) homolog [Source:UniProt...	[more]
rsd-3	6.537e-21	35.17	pep chromosome:WBcel235:X:11798505:11803656:1 gene...	[more]

BLAST of Epsin 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lqf	9.675e-66	40.61	gene:FBgn0028582 transcript:FBtr0331833	[more]
lqf	9.675e-66	40.61	gene:FBgn0028582 transcript:FBtr0331838	[more]
lqf	1.259e-65	40.61	gene:FBgn0028582 transcript:FBtr0112941	[more]
lqf	1.275e-65	39.34	gene:FBgn0028582 transcript:FBtr0331835	[more]
lqf	8.951e-65	40.61	gene:FBgn0028582 transcript:FBtr0331837	[more]

BLAST of Epsin 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
epn2	3.111e-68	40.95	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]
epn2	1.044e-67	40.38	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]
epn2	1.473e-67	47.47	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]
epn2	5.573e-67	46.04	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]
epn1	3.344e-65	36.84	epsin 1 [Source:ZFIN;Acc:ZDB-GENE-040426-2680]	[more]

BLAST of Epsin 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
uvssa	5.154e-68	39.34	UV stimulated scaffold protein A [Source:Xenbase;A...	[more]
uvssa	9.873e-68	32.75	UV stimulated scaffold protein A [Source:Xenbase;A...	[more]
uvssa	3.333e-66	39.20	UV stimulated scaffold protein A [Source:Xenbase;A...	[more]
epn2	3.565e-64	38.38	epsin2 [Source:NCBI gene;Acc:448609]	[more]
epn2	3.045e-63	37.95	epsin2 [Source:NCBI gene;Acc:448609]	[more]

BLAST of Epsin 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Epn1	7.143e-68	37.50	epsin 1 [Source:MGI Symbol;Acc:MGI:1333763]	[more]
Epn1	7.967e-68	37.50	epsin 1 [Source:MGI Symbol;Acc:MGI:1333763]	[more]
Epn1	7.967e-68	37.50	epsin 1 [Source:MGI Symbol;Acc:MGI:1333763]	[more]
Epn2	2.124e-65	45.53	epsin 2 [Source:MGI Symbol;Acc:MGI:1333766]	[more]
Epn2	2.528e-65	45.53	epsin 2 [Source:MGI Symbol;Acc:MGI:1333766]	[more]

BLAST of Epsin 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q80VP1\|EPN1_MOUSE	5.573e-67	37.50	Epsin-1 OS=Mus musculus OX=10090 GN=Epn1 PE=1 SV=3	[more]
sp\|Q9Z1Z3\|EPN2_RAT	1.578e-64	38.03	Epsin-2 OS=Rattus norvegicus OX=10116 GN=Epn2 PE=1...	[more]
sp\|Q9Y6I3\|EPN1_HUMAN	1.820e-64	37.57	Epsin-1 OS=Homo sapiens OX=9606 GN=EPN1 PE=1 SV=2	[more]
sp\|O88339\|EPN1_RAT	3.222e-64	45.60	Epsin-1 OS=Rattus norvegicus OX=10116 GN=Epn1 PE=1...	[more]
sp\|Q8CHU3\|EPN2_MOUSE	6.926e-63	44.53	Epsin-2 OS=Mus musculus OX=10090 GN=Epn2 PE=1 SV=1	[more]

BLAST of Epsin 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
V9KJM3	9.908e-71	32.38	Epsin-3-like protein OS=Callorhinchus milii OX=786...	[more]
A0A2A2KJI6	1.833e-70	43.66	ENTH domain-containing protein OS=Diploscapter pac...	[more]
A0A1I7TMY2	1.293e-69	41.79	ENTH domain-containing protein OS=Caenorhabditis t...	[more]
A0A0P4WAE4	1.333e-68	35.49	ENTH domain-containing protein OS=Scylla olivacea ...	[more]
A0A267GT68	4.164e-68	40.53	ENTH domain-containing protein OS=Macrostomum lign...	[more]

BLAST of Epsin 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
epn1	2.262e-64	49.59	epsin-1-like [Source:NCBI gene;Acc:103024066]	[more]
epn2	5.713e-63	47.54	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]
epn3b	2.593e-60	37.04	epsin-3-like [Source:NCBI gene;Acc:103023012]	[more]
epn3a	5.401e-57	34.46	epsin 3 [Source:NCBI gene;Acc:103029089]	[more]
epn3a	2.642e-56	34.00	epsin 3 [Source:NCBI gene;Acc:103029089]	[more]

BLAST of Epsin 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
epn2	1.759e-66	39.31	epsin 2 [Source:ZFIN;Acc:ZDB-GENE-071212-1]	[more]
clint1a	1.178e-24	39.58	clathrin interactor 1a [Source:ZFIN;Acc:ZDB-GENE-0...	[more]

BLAST of Epsin 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
ENT3	1.345e-31	40.94	Protein containing an N-terminal epsin-like domain...	[more]
ENT2	7.291e-26	44.93	Epsin-like protein required for endocytosis and ac...	[more]
ENT1	2.727e-25	34.01	Epsin-like protein involved in endocytosis and act...	[more]
ENT4	7.570e-8	33.98	Protein of unknown function; contains an N-termina...	[more]
ENT5	9.900e-7	27.27	Protein containing an N-terminal epsin-like domain...	[more]

BLAST of Epsin 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO36992	5.899e-62	62.18	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48788	8.097e-28	42.38	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Epsin 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
epn2	1.920e-66	48.64	epsin 2 [Source:NCBI gene;Acc:101161060]	[more]
epn1	6.260e-66	38.57	epsin-1 [Source:NCBI gene;Acc:101167232]	[more]
epn1	2.616e-65	39.19	epsin-1 [Source:NCBI gene;Acc:101167232]	[more]
epn3a	3.334e-53	46.58	epsin-1 [Source:NCBI gene;Acc:101168623]	[more]
epn3a	4.018e-53	46.58	epsin-1 [Source:NCBI gene;Acc:101168623]	[more]

BLAST of Epsin 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000042233.1	0.000e+0	98.83	SMESG000042233.1	[more]
SMESG000042233.1	0.000e+0	97.33	SMESG000042233.1	[more]
SMESG000042233.1	0.000e+0	92.49	SMESG000042233.1	[more]
SMESG000066105.1	1.750e-45	38.31	SMESG000066105.1	[more]
SMESG000019746.1	6.458e-28	41.76	SMESG000019746.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30028718 ID=SMED30028718|Name=Epsin 2|organism=Schmidtea mediterranea sexual|type=transcript|length=2489bp
CGCTAGTTAAGTGGTTTTGAAAATAATATAATAGAGCTGTTTTATTATAA
ATTTTATTATTAAATAAAACATCTCTTTACTATCTGAAAGGAATTACAAA
TGGAAATAAGAAGAAAAGTGAAAAATGTGGTATATAAATACTCAGAAGCT
GAAAAATATGTCAGGGAAGCTACATCAAATGATCCATGGGGTCCATCAAG
TACCTTAATGAGTGAAATAGCTGATATGACAAACTCTTACTCGGCTTTTG
ATGATATTATGCAATTGATTTGGAAAAGACTAAATGATAAAGGAAAGAAT
TGGAGGCATGTTTATAAGTCATTAGTGTTATTGGATTATTTAGTTAAATG
TGGAAACGAAAGAATTGCCGAAGAGTGTTTACAAAATATTCATACTATTG
AAACATTGAAAGATTTTCAATATTTTGAGGAACATAAAGATTTAGGAGTA
GGAATACGTGAAAAATCAAAAGCTTTAGTTATTTTGCTAAAAGACAAAGA
AATTCTAACTAATGAGCGATCTAAAGGATTAAAAGTTAAAGAAAAATTTC
AAAATAAGCAGTCGTCAATTGGTTCTCATCAACATCGAAGACCGGGGGAA
TTGGGTCGTGAAATTAGAAAACAATTTACTAAAGATAATCAATTTCCAAG
AACTGTTATGAAATTGAATTTCGAGGAGACCAAATCAGAAATTGAGGATG
ATGAGTTACAAAGAGCAATTGAACTTAGCAAAGAAGAACACGAAAGAGCT
ATGAAAATCAGACAAGATGAAGAACGTCGAGAAGAATTAAAAATAAAATT
AGCACTGGAACAAAGTAAAAAAGAAGAAGAGTTTGATAGAAACAATCAAA
AAGTACTAGCCGTTTTGAGGCCACCTCCAAAGGTATCTGATAAACAAAAC
AATGAAACTCTACTAAGTAAATCCGCAAAGCGTGATTCTTTATATAAACT
AAGTGAAGCTTCAAGAATATTCGATCAACAAAATGGTGACTTGAGTAGTC
TAGACGTAGATACTAAATCTGATCCTTGGGGAGCAACAGCAACAAATGTA
AAATCGCAAGATTCCAGCATTCCATTAGATTTTGATCCCTGGAAATCTCC
GGATAATAATTTCGGATCTAGTAAAACACCAATGAATACAAGCACTCCAG
ATGTATGGCTCAATAAGGATTCCAGGCAATCCAAAAACATTGTTGATGAT
ATTTTTGGAGATGAAAAACCGAATACTCAGTTCGCGTCGAATTGGAATTT
TGATGTTAATGGATTAACTCCAAGCAACCAAAACAAAATTATTGATTCGA
ATCCTTGGGAAGAATCGGATAGTTCTTTCGGTCAATTGACTAAAAATACA
ACAGGGTCTTTGGCTTCATTGACTGATATTGGTAACGACCTATCAAGAGA
AAAGAAACATTCCTGCAGCGTTACAGATTTATTGGACACGAATACAAGCA
CCAATAAAAAGAAAACACCTCAAGAGTTTTTGGGCGAGAATGCCAATTTG
GTGAATCTGGAAAATCTTGTTCCGATTCCTAAAGCAGGAGTCTACAGAGA
TCCGATGTCTCATGTTGCTAAAAATCCATTCGGCATGACTGCTTCCGCAG
TGGTCAGTAATCCATTCAATAATCAAACTATAAATCCCAAAATTCCAATG
AATCAAATTGGTAACTCGAATAATTCTCTTTTTGCTTCTTCTGGAAATTT
GACATCAATGGGCATCAATAATGGGCAGATGAATTCCTTTACCACACCGA
TGCAGCCAACTTTTCCGATTTCTCATTCACAATATCAGGGATTTTCAACA
ATGAATAATTTCTCAAATATTCCCTGGTCCCAACCAGTTGCTCCAATTAC
AAACCAATGGGCTATCAACACTAACACAGCAAATCCATTTTTCAATTGAT
ATATAAATTTATTTTTTGACCATTTTATCGATAATGCCTCAAGTGGCTTA
AAAATTTCCCATTTATTACTACTGCACATATATATATTCGTTTTTTCTGT
TTCAATCAATATTTTTCACCGAAACATCACATTGCTGTATATTGTTGATC
ATGTTTTGTCGAGTCTTTTTTGGCTTTAAAAACAATTGTGTATGAAGTAG
AAAATTTTCTTGGTCGGATTTCAACTGAATTTTAGTCGATGACTAAAAAT
GAGTAGTTTAACAGAGTTGATTTTTATTGCGCTTTTGAGATTTTTGCGAT
AATTTGATTTGAACTCAATTATTTTTATTATTAGAGATATAAATCGTTTT
TATTGTGATAATATGGATATTTGATGCACCTCATGAGTGAGTAAACAGTG
ATATTTGTGTCATGTATTTTTAATAGTTAAATATTAGATTGATAATTTCA
TTGTTTCTTCAGCTAATACTTTGTTTGTTCAAATAAATATTTTCAATGAA
CACACCAGTGAATAATGTGGGTTTATTCAATTATTTACTTTTTGTAAATA
TTCGAAATTTATATAATTTCGAGATTGTTTTTTTTCTTG

protein sequence of SMED30028718-orf-1

>SMED30028718-orf-1 ID=SMED30028718-orf-1|Name=SMED30028718-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=600bp
MEIRRKVKNVVYKYSEAEKYVREATSNDPWGPSSTLMSEIADMTNSYSAF
DDIMQLIWKRLNDKGKNWRHVYKSLVLLDYLVKCGNERIAEECLQNIHTI
ETLKDFQYFEEHKDLGVGIREKSKALVILLKDKEILTNERSKGLKVKEKF
QNKQSSIGSHQHRRPGELGREIRKQFTKDNQFPRTVMKLNFEETKSEIED
DELQRAIELSKEEHERAMKIRQDEERREELKIKLALEQSKKEEEFDRNNQ
KVLAVLRPPPKVSDKQNNETLLSKSAKRDSLYKLSEASRIFDQQNGDLSS
LDVDTKSDPWGATATNVKSQDSSIPLDFDPWKSPDNNFGSSKTPMNTSTP
DVWLNKDSRQSKNIVDDIFGDEKPNTQFASNWNFDVNGLTPSNQNKIIDS
NPWEESDSSFGQLTKNTTGSLASLTDIGNDLSREKKHSCSVTDLLDTNTS
TNKKKTPQEFLGENANLVNLENLVPIPKAGVYRDPMSHVAKNPFGMTASA
VVSNPFNNQTINPKIPMNQIGNSNNSLFASSGNLTSMGINNGQMNSFTTP
MQPTFPISHSQYQGFSTMNNFSNIPWSQPVAPITNQWAINTNTANPFFN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000016	pharynx
PLANA:0000020	protonephridia
PLANA:0000034	epidermis
PLANA:0000099	neuron
PLANA:0002032	epidermal cell
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR003903	UIM_dom
IPR013809	ENTH
IPR008942	ENTH_VHS

Vocabulary: **biological process**
Term	Definition
GO:0006897	endocytosis

Vocabulary: **cellular component**
Term	Definition
GO:0030128	clathrin coat of endocytic vesicle

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 207..240
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 149..168
None	No IPR available	PANTHER	PTHR12276	EPSIN/ENT-RELATED	coord: 3..551
None	No IPR available	PANTHER	PTHR12276:SF48	EPSIN-1	coord: 3..551
None	No IPR available	CDD	cd16990	ENTH_Epsin	coord: 16..138 e-value: 1.32761E-68 score: 216.067
IPR003903	Ubiquitin interacting motif	SMART	SM00726	uim	coord: 198..217 e-value: 0.0023 score: 27.2 coord: 227..246 e-value: 31.0 score: 13.0
IPR003903	Ubiquitin interacting motif	PFAM	PF02809	UIM	coord: 228..242 e-value: 70.0 score: 3.7 coord: 199..214 e-value: 2.9E-4 score: 20.6
IPR003903	Ubiquitin interacting motif	PROSITE	PS50330	UIM	coord: 199..217 score: 9.89
IPR013809	ENTH domain	SMART	SM00273	enth_2	coord: 15..140 e-value: 2.3E-47 score: 173.4
IPR013809	ENTH domain	PFAM	PF01417	ENTH	coord: 14..136 e-value: 1.1E-43 score: 148.3
IPR013809	ENTH domain	PROSITE	PS50942	ENTH	coord: 9..140 score: 40.222
IPR008942	ENTH/VHS	GENE3D	G3DSA:1.25.40.90		coord: 1..140 e-value: 8.3E-58 score: 196.4
IPR008942	ENTH/VHS	SUPERFAMILY	SSF48464	ENTH/VHS domain	coord: 2..140