Eukaryotic translation initiation factor 1A

Overview


Name	Eukaryotic translation initiation factor 1A
Smed ID	SMED30028670
Length (bp)	740

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Eukaryotic translation initiation factor 1A (SMED30028670) t-SNE clustered cells

Violin plots show distribution of expression levels for Eukaryotic translation initiation factor 1A (SMED30028670) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Eukaryotic translation initiation factor 1A (SMED30028670) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30028670

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 10

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30028670	h1SMcG0016796	dd_Smed_v4_334_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30028670	h1SMcG0016796	dd_Smed_v4_334_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30028670	h1SMcG0016796	dd_Smed_v4_334_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30028670	h1SMcG0016796	dd_Smed_v4_334_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30028670	h1SMcG0016796	dd_Smed_v4_334_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30028670	h1SMcG0016796	dd_Smed_v4_334_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30028670	h1SMcG0016796	Contig42877	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30028670	h1SMcG0016796	Contig42877	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30028670	h1SMcG0016796	Contig11054	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30028670	h1SMcG0016796	Contig11054	uc_Smed_v2	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Human
Match: EIF1AX (eukaryotic translation initiation factor 1A X-linked [Source:HGNC Symbol;Acc:HGNC:3250])

HSP 1 Score: 167.933 bits (424), Expect = 2.716e-52
Identity = 100/131 (76.34%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Human
Match: EIF1AY (eukaryotic translation initiation factor 1A Y-linked [Source:HGNC Symbol;Acc:HGNC:3252])

HSP 1 Score: 167.548 bits (423), Expect = 3.232e-52
Identity = 100/131 (76.34%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Human
Match: EIF1AX (eukaryotic translation initiation factor 1A X-linked [Source:HGNC Symbol;Acc:HGNC:3250])

HSP 1 Score: 146.362 bits (368), Expect = 3.025e-44
Identity = 72/99 (72.73%), Postives = 84/99 (84.85%), Query Frame = 3

Query:  123 QEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            +EYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    5 KEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 103

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Human
Match: EIF1AY (eukaryotic translation initiation factor 1A Y-linked [Source:HGNC Symbol;Acc:HGNC:3252])

HSP 1 Score: 125.561 bits (314), Expect = 5.845e-36
Identity = 85/131 (64.89%), Postives = 99/131 (75.57%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKK                 DNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCHIRGKLRKK-----------------DNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 114

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Celegans
Match: eif-1.A (Eukaryotic Initiation Factor [Source:UniProtKB/TrEMBL;Acc:Q9TXU7])

HSP 1 Score: 147.517 bits (371), Expect = 8.021e-44
Identity = 91/133 (68.42%), Postives = 106/133 (79.70%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAAQIDPV 425
            MPKNKGKGGKNRRRGKNEN+ MKREL  KE GQEY +V K+LGNGR++  CFDGK+R+CHIRGKLRKKVWIN GDIILVGLRDYQD+K DVI+KY  +EAR LK  G IP+N K+ E ND + +     +D V
Sbjct:    1 MPKNKGKGGKNRRRGKNENDFMKRELDLKEEGQEYGQVSKMLGNGRVQVFCFDGKQRVCHIRGKLRKKVWINVGDIILVGLRDYQDDKGDVILKYTPDEARRLKNEGLIPENAKLNE-NDEQDEGEVEFLDHV 132

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BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Fly
Match: eIF1A (gene:FBgn0026250 transcript:FBtr0083572)

HSP 1 Score: 166.392 bits (420), Expect = 5.043e-52
Identity = 84/115 (73.04%), Postives = 93/115 (80.87%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE---------DNDIEF 395
            ENE  KRELI+KE  QEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWINQGDIILVGLRDYQD+KADVI+KY  +EARNLK YGE P++V+I E         D DIEF
Sbjct:   18 ENEFEKRELIFKEDQQEYAQVTKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINQGDIILVGLRDYQDSKADVILKYTPDEARNLKTYGEFPESVRINETVTFVEDGFDEDIEF 132

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Fly
Match: eIF1A (gene:FBgn0026250 transcript:FBtr0083573)

HSP 1 Score: 166.392 bits (420), Expect = 5.043e-52
Identity = 84/115 (73.04%), Postives = 93/115 (80.87%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE---------DNDIEF 395
            ENE  KRELI+KE  QEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWINQGDIILVGLRDYQD+KADVI+KY  +EARNLK YGE P++V+I E         D DIEF
Sbjct:   18 ENEFEKRELIFKEDQQEYAQVTKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINQGDIILVGLRDYQDSKADVILKYTPDEARNLKTYGEFPESVRINETVTFVEDGFDEDIEF 132

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Fly
Match: eIF1A (gene:FBgn0026250 transcript:FBtr0343927)

HSP 1 Score: 166.392 bits (420), Expect = 5.043e-52
Identity = 84/115 (73.04%), Postives = 93/115 (80.87%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE---------DNDIEF 395
            ENE  KRELI+KE  QEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWINQGDIILVGLRDYQD+KADVI+KY  +EARNLK YGE P++V+I E         D DIEF
Sbjct:   18 ENEFEKRELIFKEDQQEYAQVTKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINQGDIILVGLRDYQDSKADVILKYTPDEARNLKTYGEFPESVRINETVTFVEDGFDEDIEF 132

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Zebrafish
Match: eif1axb (eukaryotic translation initiation factor 1A X-linked b [Source:ZFIN;Acc:ZDB-GENE-030131-1319])

HSP 1 Score: 167.933 bits (424), Expect = 2.065e-52
Identity = 82/114 (71.93%), Postives = 97/114 (85.09%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIIL+GLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Zebrafish
Match: eif1axb (eukaryotic translation initiation factor 1A X-linked b [Source:ZFIN;Acc:ZDB-GENE-030131-1319])

HSP 1 Score: 167.933 bits (424), Expect = 2.088e-52
Identity = 82/114 (71.93%), Postives = 97/114 (85.09%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIIL+GLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Zebrafish
Match: eif1axb (eukaryotic translation initiation factor 1A X-linked b [Source:ZFIN;Acc:ZDB-GENE-030131-1319])

HSP 1 Score: 167.548 bits (423), Expect = 2.434e-52
Identity = 99/131 (75.57%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIIL+GLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Zebrafish
Match: eif1axb (eukaryotic translation initiation factor 1A X-linked b [Source:ZFIN;Acc:ZDB-GENE-030131-1319])

HSP 1 Score: 167.162 bits (422), Expect = 2.912e-52
Identity = 99/131 (75.57%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIIL+GLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Zebrafish
Match: eif1axa (eukaryotic translation initiation factor 1A X-linked a [Source:ZFIN;Acc:ZDB-GENE-041010-185])

HSP 1 Score: 164.851 bits (416), Expect = 2.825e-51
Identity = 84/124 (67.74%), Postives = 98/124 (79.03%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEFDAAAAQIDPV 425
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQD KADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I FD      D +
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDVKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEILFDDIGENDDDI 141

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Xenopus
Match: eif1ax (eukaryotic translation initiation factor 1A X-linked [Source:NCBI gene;Acc:448063])

HSP 1 Score: 167.933 bits (424), Expect = 2.462e-52
Identity = 100/131 (76.34%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Xenopus
Match: eif1ax (eukaryotic translation initiation factor 1A X-linked [Source:NCBI gene;Acc:448063])

HSP 1 Score: 168.318 bits (425), Expect = 2.501e-52
Identity = 83/114 (72.81%), Postives = 97/114 (85.09%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Mouse
Match: Eif1ax (eukaryotic translation initiation factor 1A, X-linked [Source:MGI Symbol;Acc:MGI:1913485])

HSP 1 Score: 167.933 bits (424), Expect = 1.865e-52
Identity = 100/131 (76.34%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Mouse
Match: Eif1a (eukaryotic translation initiation factor 1A [Source:MGI Symbol;Acc:MGI:95298])

HSP 1 Score: 166.392 bits (420), Expect = 7.026e-52
Identity = 81/114 (71.05%), Postives = 97/114 (85.09%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG +RLCHIRGKLRKKVWIN  DIIL+GLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG +RLCHIRGKLRKKVWIN  DIIL+GLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG +RLCHIRGKLRKKVWIN  DIIL+GLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG +RLCHIRGKLRKKVWIN  DIIL+GLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. UniProt/SwissProt
Match: sp|Q5RA42|IF1AX_PONAB (Eukaryotic translation initiation factor 1A, X-chromosomal OS=Pongo abelii OX=9601 GN=EIF1AX PE=2 SV=3)

HSP 1 Score: 167.933 bits (424), Expect = 1.304e-51
Identity = 100/131 (76.34%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. UniProt/SwissProt
Match: sp|Q8BMJ3|IF1AX_MOUSE (Eukaryotic translation initiation factor 1A, X-chromosomal OS=Mus musculus OX=10090 GN=Eif1ax PE=2 SV=3)

HSP 1 Score: 167.933 bits (424), Expect = 1.304e-51
Identity = 100/131 (76.34%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. UniProt/SwissProt
Match: sp|P47813|IF1AX_HUMAN (Eukaryotic translation initiation factor 1A, X-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AX PE=1 SV=2)

HSP 1 Score: 167.933 bits (424), Expect = 1.304e-51
Identity = 100/131 (76.34%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. UniProt/SwissProt
Match: sp|O14602|IF1AY_HUMAN (Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Homo sapiens OX=9606 GN=EIF1AY PE=1 SV=4)

HSP 1 Score: 167.548 bits (423), Expect = 1.552e-51
Identity = 100/131 (76.34%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. UniProt/SwissProt
Match: sp|Q6GVM3|IF1AY_PANTR (Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Pan troglodytes OX=9598 GN=EIF1AY PE=2 SV=3)

HSP 1 Score: 167.162 bits (422), Expect = 2.059e-51
Identity = 97/117 (82.91%), Postives = 108/117 (92.31%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE 377
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEALCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINE 117

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. TrEMBL
Match: A0A1I8HGH2 (S1-like domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig033687g1 PE=3 SV=1)

HSP 1 Score: 191.43 bits (485), Expect = 2.493e-58
Identity = 92/111 (82.88%), Postives = 98/111 (88.29%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAA 410
            ENE+MKREL+YKE GQEY KVEK+LGNGRLEA CFDG KRLCHIRGKLRKKVWINQGDIILVGLRDYQD KADVIMKYN +E RNLK YGEIP++VKIEED DI FD  A 
Sbjct:   18 ENESMKRELVYKEDGQEYGKVEKMLGNGRLEAYCFDGVKRLCHIRGKLRKKVWINQGDIILVGLRDYQDTKADVIMKYNPDEVRNLKTYGEIPESVKIEEDADIAFDHTAV 128

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. TrEMBL
Match: A0A1I8J721 (S1-like domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig033687g3 PE=3 SV=1)

HSP 1 Score: 191.43 bits (485), Expect = 2.604e-58
Identity = 92/111 (82.88%), Postives = 98/111 (88.29%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAA 410
            ENE+MKREL+YKE GQEY KVEK+LGNGRLEA CFDG KRLCHIRGKLRKKVWINQGDIILVGLRDYQD KADVIMKYN +E RNLK YGEIP++VKIEED DI FD  A 
Sbjct:   18 ENESMKRELVYKEDGQEYGKVEKMLGNGRLEAYCFDGVKRLCHIRGKLRKKVWINQGDIILVGLRDYQDTKADVIMKYNPDEVRNLKTYGEIPESVKIEEDADIAFDHTAV 128

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. TrEMBL
Match: A0A4S2MIE3 (S1-like domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_001045 PE=3 SV=1)

HSP 1 Score: 186.808 bits (473), Expect = 4.917e-56
Identity = 108/128 (84.38%), Postives = 116/128 (90.62%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAA 410
            MPKNKGKGGKNRRRGKNENE+ KRELIYKE GQEYAKVE++LGNGRLEA CFDG KRLCHIRGKLRKKVWI+ GDIILVGLRDYQD KADVIMKY  +EAR LK+ GEIPD VK+EE+NDIEFDA AA
Sbjct:    1 MPKNKGKGGKNRRRGKNENESQKRELIYKEAGQEYAKVERLLGNGRLEAYCFDGVKRLCHIRGKLRKKVWISNGDIILVGLRDYQDKKADVIMKYLNDEARTLKSLGEIPDTVKLEENNDIEFDANAA 128

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. TrEMBL
Match: A0A1S8WZG6 (Translation initiation factor eIF-1A OS=Opisthorchis viverrini OX=6198 GN=X801_04323 PE=3 SV=1)

HSP 1 Score: 186.808 bits (473), Expect = 4.917e-56
Identity = 108/128 (84.38%), Postives = 116/128 (90.62%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAA 410
            MPKNKGKGGKNRRRGKNENE+ KRELIYKE GQEYAKVE++LGNGRLEA CFDG KRLCHIRGKLRKKVWI+ GDIILVGLRDYQD KADVIMKY  +EAR LK+ GEIPD VK+EE+NDIEFDA AA
Sbjct:    1 MPKNKGKGGKNRRRGKNENESQKRELIYKEAGQEYAKVERLLGNGRLEAYCFDGVKRLCHIRGKLRKKVWISNGDIILVGLRDYQDKKADVIMKYLNDEARTLKSLGEIPDTVKLEENNDIEFDANAA 128

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. TrEMBL
Match: G7Y8V7 (Eukaryotic translation initiation factor 1A OS=Clonorchis sinensis OX=79923 GN=EIF1AX PE=3 SV=1)

HSP 1 Score: 186.808 bits (473), Expect = 4.917e-56
Identity = 108/128 (84.38%), Postives = 116/128 (90.62%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAA 410
            MPKNKGKGGKNRRRGKNENE+ KRELIYKE GQEYAKVE++LGNGRLEA CFDG KRLCHIRGKLRKKVWI+ GDIILVGLRDYQD KADVIMKY  +EAR LK+ GEIPD VK+EE+NDIEFDA AA
Sbjct:    1 MPKNKGKGGKNRRRGKNENESQKRELIYKEAGQEYAKVERLLGNGRLEAYCFDGVKRLCHIRGKLRKKVWISNGDIILVGLRDYQDKKADVIMKYLNDEARTLKSLGEIPDTVKLEENNDIEFDANAA 128

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Cavefish
Match: eif1axb (eukaryotic translation initiation factor 1A X-linked [Source:NCBI gene;Acc:103023597])

HSP 1 Score: 167.548 bits (423), Expect = 2.238e-52
Identity = 99/131 (75.57%), Postives = 114/131 (87.02%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIIL+GLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGGGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Cavefish
Match: ENSAMXT00000052610.1 (eukaryotic translation initiation factor 1A, X-chromosomal-like [Source:NCBI gene;Acc:103023571])

HSP 1 Score: 165.236 bits (417), Expect = 1.596e-51
Identity = 82/114 (71.93%), Postives = 96/114 (84.21%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQD KADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDVKADVILKYNADEARSLKAYGELPEHAKINETDTFGGGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Cavefish
Match: ENSAMXT00000057212.1 (eukaryotic translation initiation factor 1A, X-chromosomal-like [Source:NCBI gene;Acc:103023571])

HSP 1 Score: 164.851 bits (416), Expect = 2.473e-51
Identity = 82/114 (71.93%), Postives = 96/114 (84.21%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQD KADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKKVWINTSDIILVGLRDYQDVKADVILKYNADEARSLKAYGELPEHAKINETDTFGGGDDDEIQF 131

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Cavefish
Match: eif1axb (eukaryotic translation initiation factor 1A X-linked [Source:NCBI gene;Acc:103023597])

HSP 1 Score: 126.331 bits (316), Expect = 1.999e-36
Identity = 85/131 (64.89%), Postives = 99/131 (75.57%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKK                 DNKADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKK-----------------DNKADVILKYNADEARSLKAYGELPEHAKINETDTFGGGDDDEIQF 114

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Cavefish
Match: ENSAMXT00000007012.2 (eukaryotic translation initiation factor 1A, X-chromosomal-like [Source:NCBI gene;Acc:103023571])

HSP 1 Score: 122.865 bits (307), Expect = 3.354e-35
Identity = 84/131 (64.12%), Postives = 98/131 (74.81%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE--------DNDIEF 395
            MPKNKGKGGKNRRRGKNENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKK                 D KADVI+KYNA+EAR+LKAYGE+P++ KI E        D++I+F
Sbjct:    1 MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKRLCHIRGKLRKK-----------------DVKADVILKYNADEARSLKAYGELPEHAKINETDTFGGGDDDEIQF 114

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Sea Lamprey
Match: eif1ad (eukaryotic translation initiation factor 1A domain containing [Source:NCBI gene;Acc:393440])

HSP 1 Score: 45.4394 bits (106), Expect = 2.896e-6
Identity = 35/110 (31.82%), Postives = 55/110 (50.00%), Query Frame = 3

Query:   93 KRELIYKETGQEYA------KVEKILG---NGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDN-KADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIE 392
            KR+ + KE  +E+A      ++ K+LG   N   E +   G+  L  +  K RK +WI +GD ++V   +  D  KA+++   N +  R LK  G  P  VK  ED  +E
Sbjct:    6 KRKHVVKEVLEEFAAPTRQQQIVKVLGTPGNNLHEVETAVGEHFLVTMPTKYRKNIWIKRGDFVMVEPIEEGDKVKAEIVSILNRDHIRYLKKEGVWP--VKFNEDTSVE 113

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Yeast
Match: TIF11 (Translation initiation factor eIF1A; essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 [Source:SGD;Acc:S000004873])

HSP 1 Score: 149.058 bits (375), Expect = 5.948e-46
Identity = 68/103 (66.02%), Postives = 85/103 (82.52%), Query Frame = 3

Query:   93 KRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDA 401
            KRELIYKE GQEYA++ K+LGNGR+EA CFDG KR+ HIRGKLRKKVW+ QGDIILV LRD+QD++ DV+ KYN +EAR LK  GE+P+N KI E ++  F++
Sbjct:   23 KRELIYKEEGQEYAQITKMLGNGRVEASCFDGNKRMAHIRGKLRKKVWMGQGDIILVSLRDFQDDQCDVVHKYNLDEARTLKNQGELPENAKINETDNFGFES 125

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Nematostella
Match: EDO31721 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX41])

HSP 1 Score: 168.318 bits (425), Expect = 2.145e-53
Identity = 83/115 (72.17%), Postives = 97/115 (84.35%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKI--------EEDNDIEFD 398
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN GDIIL+GLRDYQD KADVI++YN +EARNLKAYGE+P+N KI        EE+++I FD
Sbjct:   14 ENESEKRELVFKEDGQEYAQVVKMLGNGRLEALCFDGMKRLCHIRGKLRKKVWINTGDIILLGLRDYQDTKADVILRYNPDEARNLKAYGELPENAKINDTNMFGPEEEDEITFD 128

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Nematostella
Match: EDO32419 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SV47])

HSP 1 Score: 168.703 bits (426), Expect = 2.383e-53
Identity = 83/115 (72.17%), Postives = 97/115 (84.35%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKI--------EEDNDIEFD 398
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN GDIIL+GLRDYQD KADVI++YN +EARNLKAYGE+P+N KI        EE+++I FD
Sbjct:   18 ENESEKRELVFKEDGQEYAQVVKMLGNGRLEALCFDGMKRLCHIRGKLRKKVWINTGDIILLGLRDYQDTKADVILRYNPDEARNLKAYGELPENAKINDTNMFGPEEEDEITFD 132

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Nematostella
Match: EDO28767 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T5J5])

HSP 1 Score: 84.7297 bits (208), Expect = 1.192e-21
Identity = 42/64 (65.62%), Postives = 51/64 (79.69%), Query Frame = 3

Query:  231 VWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKI--------EEDNDIEFD 398
            VWIN GDIIL+GLRDYQD KADVI++YN +EARNLKAYGE+P+N KI        EE+++I FD
Sbjct:    1 VWINTGDIILLGLRDYQDTKADVILRYNPDEARNLKAYGELPENAKINDTNMFGPEEEDEITFD 64

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Medaka
Match: eif1axa (eukaryotic translation initiation factor 1A, X-chromosomal [Source:NCBI gene;Acc:101173816])

HSP 1 Score: 167.933 bits (424), Expect = 1.196e-52
Identity = 80/100 (80.00%), Postives = 91/100 (91.00%), Query Frame = 3

Query:   78 ENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEE 377
            ENE+ KREL++KE GQEYA+V K+LGNGRLEA CFDG KRLCHIRGKLRKKVWIN  DIILVGLRDYQDNKADVI+KYNA+EAR+LKAYGE+P++ KI E
Sbjct:   18 ENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGTKRLCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINE 117

[Close]

BLAST of Eukaryotic translation initiation factor 1A vs. Planmine SMEST
Match: SMESG000077643.1 (SMESG000077643.1)

HSP 1 Score: 304.679 bits (779), Expect = 5.153e-106
Identity = 190/190 (100.00%), Postives = 190/190 (100.00%), Query Frame = 3

Query:   27 MPXXXXXXXXXXXXXXXENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAAQIDPVVEGQXXXXXXXXXXXXXXXXXXXXIPSWASKNPTRNTKWDRNHQRGKKNNENFIEKI 596
            MPKNKGKGGKNRRRGKNENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAAQIDPVVEGQSEDEESDESDEEEEEEEDEDIPSWASKNPTRNTKWDRNHQRGKKNNENFIEKI
Sbjct:    1 MPKNKGKGGKNRRRGKNENETMKRELIYKETGQEYAKVEKILGNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVIMKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAAQIDPVVEGQSEDEESDESDEEEEEEEDEDIPSWASKNPTRNTKWDRNHQRGKKNNENFIEKI 190

The following BLAST results are available for this feature:

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Human
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Celegans
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Fly
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Zebrafish
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Xenopus
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Mouse
BLAST of Eukaryotic translation initiation factor 1A vs. UniProt/SwissProt
BLAST of Eukaryotic translation initiation factor 1A vs. TrEMBL
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Cavefish
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Sea Lamprey
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Yeast
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Nematostella
BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Medaka
BLAST of Eukaryotic translation initiation factor 1A vs. Planmine SMEST

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 4


Match Name	E-value	Identity	Description
EIF1AX	2.716e-52	76.34	eukaryotic translation initiation factor 1A X-link...	[more]
EIF1AY	3.232e-52	76.34	eukaryotic translation initiation factor 1A Y-link...	[more]
EIF1AX	3.025e-44	72.73	eukaryotic translation initiation factor 1A X-link...	[more]
EIF1AY	5.845e-36	64.89	eukaryotic translation initiation factor 1A Y-link...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
eif-1.A	8.021e-44	68.42	Eukaryotic Initiation Factor [Source:UniProtKB/Tr...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
eIF1A	5.043e-52	73.04	gene:FBgn0026250 transcript:FBtr0083572	[more]
eIF1A	5.043e-52	73.04	gene:FBgn0026250 transcript:FBtr0083573	[more]
eIF1A	5.043e-52	73.04	gene:FBgn0026250 transcript:FBtr0343927	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eif1axb	2.065e-52	71.93	eukaryotic translation initiation factor 1A X-link...	[more]
eif1axb	2.088e-52	71.93	eukaryotic translation initiation factor 1A X-link...	[more]
eif1axb	2.434e-52	75.57	eukaryotic translation initiation factor 1A X-link...	[more]
eif1axb	2.912e-52	75.57	eukaryotic translation initiation factor 1A X-link...	[more]
eif1axa	2.825e-51	67.74	eukaryotic translation initiation factor 1A X-link...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2


Match Name	E-value	Identity	Description
eif1ax	2.462e-52	76.34	eukaryotic translation initiation factor 1A X-link...	[more]
eif1ax	2.501e-52	72.81	eukaryotic translation initiation factor 1A X-link...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Eif1ax	1.865e-52	76.34	eukaryotic translation initiation factor 1A, X-lin...	[more]
Eif1a	7.026e-52	71.05	eukaryotic translation initiation factor 1A [Sourc...	[more]
Eif1a	7.026e-52	71.05	eukaryotic translation initiation factor 1A [Sourc...	[more]
Eif1a	7.026e-52	71.05	eukaryotic translation initiation factor 1A [Sourc...	[more]
Eif1a	7.026e-52	71.05	eukaryotic translation initiation factor 1A [Sourc...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q5RA42\|IF1AX_PONAB	1.304e-51	76.34	Eukaryotic translation initiation factor 1A, X-chr...	[more]
sp\|Q8BMJ3\|IF1AX_MOUSE	1.304e-51	76.34	Eukaryotic translation initiation factor 1A, X-chr...	[more]
sp\|P47813\|IF1AX_HUMAN	1.304e-51	76.34	Eukaryotic translation initiation factor 1A, X-chr...	[more]
sp\|O14602\|IF1AY_HUMAN	1.552e-51	76.34	Eukaryotic translation initiation factor 1A, Y-chr...	[more]
sp\|Q6GVM3\|IF1AY_PANTR	2.059e-51	82.91	Eukaryotic translation initiation factor 1A, Y-chr...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A1I8HGH2	2.493e-58	82.88	S1-like domain-containing protein OS=Macrostomum l...	[more]
A0A1I8J721	2.604e-58	82.88	S1-like domain-containing protein OS=Macrostomum l...	[more]
A0A4S2MIE3	4.917e-56	84.38	S1-like domain-containing protein OS=Opisthorchis ...	[more]
A0A1S8WZG6	4.917e-56	84.38	Translation initiation factor eIF-1A OS=Opisthorch...	[more]
G7Y8V7	4.917e-56	84.38	Eukaryotic translation initiation factor 1A OS=Clo...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
eif1axb	2.238e-52	75.57	eukaryotic translation initiation factor 1A X-link...	[more]
ENSAMXT00000052610.1	1.596e-51	71.93	eukaryotic translation initiation factor 1A, X-chr...	[more]
ENSAMXT00000057212.1	2.473e-51	71.93	eukaryotic translation initiation factor 1A, X-chr...	[more]
eif1axb	1.999e-36	64.89	eukaryotic translation initiation factor 1A X-link...	[more]
ENSAMXT00000007012.2	3.354e-35	64.12	eukaryotic translation initiation factor 1A, X-chr...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
eif1ad	2.896e-6	31.82	eukaryotic translation initiation factor 1A domain...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
TIF11	5.948e-46	66.02	Translation initiation factor eIF1A; essential pro...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO31721	2.145e-53	72.17	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO32419	2.383e-53	72.17	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO28767	1.192e-21	65.63	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
eif1axa	1.196e-52	80.00	eukaryotic translation initiation factor 1A, X-chr...	[more]

BLAST of Eukaryotic translation initiation factor 1A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1


Match Name	E-value	Identity	Description
SMESG000077643.1	5.153e-106	100.00	SMESG000077643.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30028670 ID=SMED30028670|Name=Eukaryotic translation initiation factor 1A|organism=Schmidtea mediterranea sexual|type=transcript|length=740bp
GTTGCAATAGCACTTTTTCAAAACCAATGCCAAAAAATAAAGGTAAGGGA
GGTAAAAATCGACGTCGTGGAAAGAATGAAAATGAAACCATGAAGCGTGA
ACTTATATACAAAGAAACCGGTCAAGAATATGCAAAAGTAGAAAAAATTT
TAGGTAATGGACGTCTTGAGGCAGATTGTTTCGATGGTAAGAAAAGGCTA
TGTCATATTAGGGGAAAATTACGAAAAAAGGTGTGGATAAATCAAGGGGA
TATTATTCTTGTGGGACTTAGGGATTATCAAGATAACAAAGCAGATGTCA
TTATGAAATATAATGCTGAAGAAGCTCGAAATTTGAAGGCATACGGGGAA
ATTCCTGACAATGTTAAAATTGAAGAAGATAATGATATTGAATTTGATGC
TGCCGCTGCACAAATCGATCCAGTAGTTGAAGGACAAAGTGAAGATGAAG
AATCTGATGAATCAGATGAAGAGGAAGAGGAGGAAGAAGATGAAGATATT
CCTAGTTGGGCCTCAAAAAATCCCACCAGAAATACCAAATGGGATCGAAA
TCATCAGAGAGGTAAAAAGAATAACGAAAATTTCATTGAAAAGATCTAAA
TTTGGCTATCGCGATTGGATGAAATTTTCTAATCTAATATATTTAGTTCG
GCTTCATTTGTATACTAAGTTAAAAATTATTTAATCCTGTTCTATACATT
GTATGGTGCCATATGAATAAATGTGTTTAAGTCATAAAAA

protein sequence of SMED30028670-orf-1

>SMED30028670-orf-1 ID=SMED30028670-orf-1|Name=SMED30028670-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=199bp
CNSTFSKPMPKNKGKGGKNRRRGKNENETMKRELIYKETGQEYAKVEKIL
GNGRLEADCFDGKKRLCHIRGKLRKKVWINQGDIILVGLRDYQDNKADVI
MKYNAEEARNLKAYGEIPDNVKIEEDNDIEFDAAAAQIDPVVEGQSEDEE
SDESDEEEEEEEDEDIPSWASKNPTRNTKWDRNHQRGKKNNENFIEKI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron
PLANA:0000429	neoblast

Vocabulary: **INTERPRO**
Term	Definition
IPR001253	TIF_eIF-1A
IPR012340	NA-bd_OB-fold
IPR006196	RNA-binding_domain_S1_IF1
IPR018104	TIF_eIF-1A_CS

Vocabulary: **molecular function**
Term	Definition
GO:0003743	translation initiation factor activity
GO:0003723	RNA binding
GO:0043023	ribosomal large subunit binding

Vocabulary: **biological process**
Term	Definition
GO:0006413	translational initiation
GO:0006412	translation
GO:0008150	biological_process

Vocabulary: **cellular component**
Term	Definition
GO:0005575	cellular_component

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001253	Translation initiation factor 1A (eIF-1A)	SMART	SM00652	eIF1neu4	coord: 36..118 e-value: 3.6E-45 score: 166.1
IPR001253	Translation initiation factor 1A (eIF-1A)	TIGRFAM	TIGR00523	TIGR00523	coord: 22..117 e-value: 5.2E-37 score: 123.8
IPR001253	Translation initiation factor 1A (eIF-1A)	PANTHER	PTHR21668	EIF-1A	coord: 9..141
IPR001253	Translation initiation factor 1A (eIF-1A)	CDD	cd05793	S1_IF1A	coord: 41..117 e-value: 3.25433E-43 score: 137.27
IPR006196	RNA-binding domain, S1, IF1 type	PFAM	PF01176	eIF-1a	coord: 40..101 e-value: 2.7E-22 score: 78.3
IPR006196	RNA-binding domain, S1, IF1 type	PROSITE	PS50832	S1_IF1_TYPE	coord: 30..104 score: 32.283
None	No IPR available	GENE3D	G3DSA:2.40.50.140		coord: 10..167 e-value: 1.3E-53 score: 182.3
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 143..166
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 138..198
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..29
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 177..198
None	No IPR available	PANTHER	PTHR21668:SF4	EUKARYOTIC TRANSLATION INITIATION FACTOR 1A, X-CHROMOSOMAL	coord: 9..141
None	No IPR available	PRODOM	PD005579		coord: 61..117 e-value: 1.0E-20 score: 245.0
IPR018104	Translation initiation factor 1A (eIF-1A), conserved site	PROSITE	PS01262	IF1A	coord: 49..71
IPR012340	Nucleic acid-binding, OB-fold	SUPERFAMILY	SSF50249	Nucleic acid-binding proteins	coord: 10..165