COP9 signalosome complex subunit 5

Overview


Name	COP9 signalosome complex subunit 5 (AHY82401.1)
Smed ID	SMED30028667
Length (bp)	1150

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of COP9 signalosome complex subunit 5 (SMED30028667) t-SNE clustered cells

Violin plots show distribution of expression levels for COP9 signalosome complex subunit 5 (SMED30028667) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of COP9 signalosome complex subunit 5 (SMED30028667) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for COP9 signalosome complex subunit 5 (SMED30028667) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30028667

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 1

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
X2 cell	SMED30028667	SMESG000038057.1	SmedASXL_005188	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015

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Homology

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Human
Match: COPS5 (COP9 signalosome subunit 5 [Source:HGNC Symbol;Acc:HGNC:2240])

HSP 1 Score: 371.318 bits (952), Expect = 2.037e-127
Identity = 182/314 (57.96%), Postives = 237/314 (75.48%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WEL NN+      D++++YD      I+ +KPW KD HYFKY ++SA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+  ++ +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:   11 KTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 324

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Human
Match: COPS5 (COP9 signalosome subunit 5 [Source:HGNC Symbol;Acc:HGNC:2240])

HSP 1 Score: 290.041 bits (741), Expect = 1.658e-97
Identity = 132/182 (72.53%), Postives = 158/182 (86.81%), Query Frame = 1

Query:  214 MVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYW 759
            MV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +L++LWN+YW
Sbjct:    1 MVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYW 182

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Human
Match: COPS5 (COP9 signalosome subunit 5 [Source:HGNC Symbol;Acc:HGNC:2240])

HSP 1 Score: 235.728 bits (600), Expect = 7.416e-77
Identity = 110/151 (72.85%), Postives = 130/151 (86.09%), Query Frame = 1

Query:  214 MVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFG 666
            MV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFG
Sbjct:    1 MVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFG 151

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Human
Match: PSMD14 (proteasome 26S subunit, non-ATPase 14 [Source:HGNC Symbol;Acc:HGNC:16889])

HSP 1 Score: 123.25 bits (308), Expect = 1.039e-31
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:   31 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSW 225

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Human
Match: BRCC3 (BRCA1/BRCA2-containing complex subunit 3 [Source:HGNC Symbol;Acc:HGNC:24185])

HSP 1 Score: 59.6918 bits (143), Expect = 1.087e-9
Identity = 43/152 (28.29%), Postives = 68/152 (44.74%), Query Frame = 1

Query:  202 ALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVAL--PVEGTETRVNAQSEAYEFITMYKDTVAKI-GRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPV---RTVSSGKVNIGAFRTYPRHYSPPD-QGPSEYQS 636
            A L  + HA      EVMG+  G+V    ++ + SV +    +  + RV    E     +   + +A++ GR   V+GWYHSHP    W S +DV TQ M Q     FV ++       +   +G+V    F++     S     GP ++ S
Sbjct:   18 AFLVCLNHALSTEKEEVMGLCIGEVDAVRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSIQAQKSSESLHGPRDFWS 169

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Celegans
Match: csn-5 (COP9 signalosome complex subunit 5 [Source:UniProtKB/Swiss-Prot;Acc:P91001])

HSP 1 Score: 348.977 bits (894), Expect = 1.313e-118
Identity = 170/306 (55.56%), Postives = 223/306 (72.88%), Query Frame = 1

Query:   58 QSWELENNVVTINDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WE ENNV  + D +F Y+      I  +KPW KD HYFK I++SA ALLKM  HA+RGGNLE+MG+L G++  N+ I++D  ALPVEGTETRVNAQ++AYE++T+Y +     GR E V+GWYHSHPGYGCWLSGIDV+TQT+NQ +Q+P+VA+V+DP+RT+S+GKV+IGAFRTYP  Y PPD  PSEYQSIPL KIEDFGVHCK+YY L +S+FKS LD  IL  LWN YW STL+SS + S  +++    +D+ +K+++ D+KL Q      D  E   KV  DA  + +E   G +  L+K
Sbjct:   15 RNWEKENNVQNV-DSIFEYNNKQQVEIRNAKPWDKDPHYFKQIKISAIALLKMTMHAKRGGNLEIMGLLQGRIDANSFIILDVFALPVEGTETRVNAQAQAYEYMTVYSEMCDTEGRKEKVVGWYHSHPGYGCWLSGIDVSTQTLNQKFQEPWVAIVIDPLRTMSAGKVDIGAFRTYPEGYRPPDDVPSEYQSIPLAKIEDFGVHCKRYYSLDVSFFKSQLDAHILTSLWNSYWISTLSSSPLFSNVEFLNNQIQDINQKLSAVDKKL-QLNDRSVDGHEALMKVVTDAKAVGDELETGRISHLVK 318

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Celegans
Match: F37A4.5 (pep chromosome:WBcel235:III:6711869:6713191:1 gene:WBGene00018135.1 transcript:F37A4.5.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F37A4.5)

HSP 1 Score: 125.946 bits (315), Expect = 4.838e-33
Identity = 77/206 (37.38%), Postives = 113/206 (54.85%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYP------RHYSP---PDQGPSEYQSIP----LNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ HAR G  LEVMG++ G    + T+ V D  A+P  GT   V +    Y+  T + D +  +GRTENV+GWYHSHPG+GCWLS +DV TQ   +      VAVV+DP+++V  GKV + AFR+        R  +P   P Q  S    +     ++ +   G    +YY L ++Y   S ++ +L  L  + W
Sbjct:   29 VNISSLALLKMLRHARSGIPLEVMGLMLGDFVDDYTINVTDVFAMPQSGTSVTVESVDPVYQ--TKHMDLLKLVGRTENVVGWYHSHPGFGCWLSSVDVNTQQSFEALHPRAVAVVVDPIQSV-KGKVMLDAFRSVNPLNLQIRPLAPTAEPRQTTSNLGHLTKPSLISVVHGLGT---KYYSLNVAYRMGSNEQKMLMCLNKKSW 228

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Celegans
Match: rpn-11 (26S proteasome non-ATPase regulatory subunit 14 [Source:UniProtKB/Swiss-Prot;Acc:O76577])

HSP 1 Score: 125.561 bits (314), Expect = 6.854e-33
Identity = 90/282 (31.91%), Postives = 143/282 (50.71%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHC------KQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDY-------MAELTKD----LAEKVASTDRKLCQSGMHKFD----IEEEASKVSKDAAKLANEELAGLMG 963
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   D  VAVV+DP+++V  GKV I AFRT        +Q P +  S  L  ++   +        + YY + ++Y    L++ +L  L    W   ++  +     +        M +L K+    L ++   TD++L    + K D    I +E SK+  D      + LAG+M 
Sbjct:   33 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSDRAVAVVVDPIQSV-KGKVVIDAFRTINPQSMALNQEPRQTTS-NLGHLQKPSIQALIHGLNRHYYSIPIAYRTHDLEQKMLLNLNKLSWMDAVSVENYSKCGEQNKEHLKAMLKLAKNYKKALEDEKNMTDQELAIKNVGKMDPKRHIADEVSKMLNDNIV---QSLAGMMA 307

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Fly
Match: CSN5 (gene:FBgn0027053 transcript:FBtr0083292)

HSP 1 Score: 387.497 bits (994), Expect = 2.699e-134
Identity = 181/312 (58.01%), Postives = 244/312 (78.21%), Query Frame = 1

Query:   49 SSLQSWELENNVVTI--NDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQ-SGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++ ++WELENN+ T+   D++FRYD      I+ +KPW KD H+FK I++SA ALLKMV HAR GG LEVMG++ GKV  NTMIVMD+ ALPVEGTETRVNAQ++AYE++T Y +   ++GR E+ +GWYHSHPGYGCWLSGIDV+TQ +NQTYQ+PFVA+V+DPVRTVS+GKV +GAFRTYP+ Y PP++ PSEYQ+IPLNKIEDFGVHCKQYYPL +SYFKS+LD+ +LD LWN+YW +TL SS +L+  +Y      DL+EK+  ++  L + + +++   E++ SK ++D ++   E + GLM Q++K
Sbjct:    5 AAQKTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHARSGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYPKGYKPPNEEPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYWVNTLGSSGLLTNTEYTTGQIMDLSEKLEQSENFLGRGTDVNEKRSEDKLSKATRDCSRSTIELIHGLMAQIVK 316

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Fly
Match: CSN5 (gene:FBgn0027053 transcript:FBtr0334535)

HSP 1 Score: 387.111 bits (993), Expect = 3.731e-134
Identity = 181/311 (58.20%), Postives = 243/311 (78.14%), Query Frame = 1

Query:   49 SSLQSWELENNVVTI--NDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++ ++WELENN+ T+   D++FRYD      I+ +KPW KD H+FK I++SA ALLKMV HAR GG LEVMG++ GKV  NTMIVMD+ ALPVEGTETRVNAQ++AYE++T Y +   ++GR E+ +GWYHSHPGYGCWLSGIDV+TQ +NQTYQ+PFVA+V+DPVRTVS+GKV +GAFRTYP+ Y PP++ PSEYQ+IPLNKIEDFGVHCKQYYPL +SYFKS+LD+ +LD LWN+YW +TL SS +L+  +Y      DL+EK+  ++  L  + +++   E++ SK ++D ++   E + GLM Q++K
Sbjct:    5 AAQKTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHARSGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYPKGYKPPNEEPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYWVNTLGSSGLLTNTEYTTGQIMDLSEKLEQSENFL-GTDVNEKRSEDKLSKATRDCSRSTIELIHGLMAQIVK 314

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Fly
Match: Rpn11 (gene:FBgn0028694 transcript:FBtr0079027)

HSP 1 Score: 123.635 bits (309), Expect = 3.440e-32
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHC------KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +     Q P +  S  L  ++   V        + YY + ++Y K+ L++ +L  L  + W
Sbjct:   29 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVQVIDVFAMPQTGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINPNMLVLGQEPRQTTS-NLGHLQKPSVQALIHGLNRHYYSISINYRKNELEQKMLLNLHKKSW 223

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Zebrafish
Match: cops5 (COP9 signalosome subunit 5 [Source:NCBI gene;Acc:393698])

HSP 1 Score: 370.548 bits (950), Expect = 2.005e-127
Identity = 181/316 (57.28%), Postives = 239/316 (75.63%), Query Frame = 1

Query:   52 SLQSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++++WEL N++  +   D++++YD      I+ +KPW KD HYFKY ++SA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+   + +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:    7 AMKTWELSNSMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKLSALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQAEAQLGRGSFMLGLDTHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 322

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Zebrafish
Match: psmd14 (proteasome 26S subunit, non-ATPase 14 [Source:ZFIN;Acc:ZDB-GENE-070410-56])

HSP 1 Score: 122.479 bits (306), Expect = 1.501e-31
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:   31 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSW 225

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Zebrafish
Match: brcc3 (BRCA1/BRCA2-containing complex, subunit 3 [Source:ZFIN;Acc:ZDB-GENE-100215-1])

HSP 1 Score: 63.5438 bits (153), Expect = 4.808e-11
Identity = 46/160 (28.75%), Postives = 73/160 (45.62%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVAL--PVEGTETRVNAQSEAYEFITMYKDTVAKI-GRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPV---RTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPL 645
            + + + A L  + HA      EVMG+  G+V  N ++ + SV +    +  + RV    E     +   + +A++ GR   V+GWYHSHP    W S +DV TQ M Q     FV ++       +   +G+V    F+      S   Q  SEY+ I +
Sbjct:    7 VHLESDAFLVCMNHALSTEKEEVMGLCIGEVDTNRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAEMTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQ------SVQAQKGSEYERIEI 160

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Zebrafish
Match: brcc3 (BRCA1/BRCA2-containing complex, subunit 3 [Source:ZFIN;Acc:ZDB-GENE-100215-1])

HSP 1 Score: 62.7734 bits (151), Expect = 7.480e-11
Identity = 48/166 (28.92%), Postives = 74/166 (44.58%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVAL---------PVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPV---RTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPL 645
            + + + A L  + HA      EVMG+  G+V  N ++ + SV +          VE +  +++A S   E   + + T    GR   V+GWYHSHP    W S +DV TQ M Q     FV ++       +   +G+V    F+      S   Q  SEY+ I +
Sbjct:   33 VHLESDAFLVCMNHALSTEKEEVMGLCIGEVDTNRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAEISRLAEMT----GRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQ------SVQAQKGSEYERIEI 188

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Xenopus
Match: cops5 (COP9 signalosome subunit 5 [Source:NCBI gene;Acc:394714])

HSP 1 Score: 372.859 bits (956), Expect = 9.159e-128
Identity = 182/314 (57.96%), Postives = 238/314 (75.80%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WEL NN+  +   D++++YD      I+ +KPW KD HYFKY +VSA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+  ++ +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:   33 KTWELSNNMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKVSALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 346

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Xenopus
Match: cops5 (COP9 signalosome subunit 5 [Source:NCBI gene;Acc:394714])

HSP 1 Score: 372.089 bits (954), Expect = 1.262e-127
Identity = 182/314 (57.96%), Postives = 238/314 (75.80%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WEL NN+  +   D++++YD      I+ +KPW KD HYFKY +VSA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+  ++ +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:   19 KTWELSNNMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKVSALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 332

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Xenopus
Match: prokr2 (prokineticin receptor 2 [Source:Xenbase;Acc:XB-GENE-490581])

HSP 1 Score: 123.25 bits (308), Expect = 1.076e-31
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:   31 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSW 225

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Xenopus
Match: prokr2 (prokineticin receptor 2 [Source:Xenbase;Acc:XB-GENE-490581])

HSP 1 Score: 122.865 bits (307), Expect = 1.222e-31
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:   17 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSW 211

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Xenopus
Match: prokr2 (prokineticin receptor 2 [Source:Xenbase;Acc:XB-GENE-490581])

HSP 1 Score: 122.479 bits (306), Expect = 2.031e-31
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:   34 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSW 228

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Mouse
Match: Cops5 (COP9 signalosome subunit 5 [Source:MGI Symbol;Acc:MGI:1349415])

HSP 1 Score: 371.318 bits (952), Expect = 1.324e-127
Identity = 182/314 (57.96%), Postives = 237/314 (75.48%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WEL NN+      D++++YD      I+ +KPW KD HYFKY ++SA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+  ++ +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:   11 KTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 324

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Mouse
Match: Cops5 (COP9 signalosome subunit 5 [Source:MGI Symbol;Acc:MGI:1349415])

HSP 1 Score: 278.87 bits (712), Expect = 4.062e-93
Identity = 130/178 (73.03%), Postives = 153/178 (85.96%), Query Frame = 1

Query:  169 HYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMS 702
            HYFKY ++SA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +S
Sbjct:   33 HYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVS 210

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Mouse
Match: Cops5 (COP9 signalosome subunit 5 [Source:MGI Symbol;Acc:MGI:1349415])

HSP 1 Score: 198.364 bits (503), Expect = 1.665e-62
Identity = 94/131 (71.76%), Postives = 112/131 (85.50%), Query Frame = 1

Query:  202 ALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPR 594
            ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+
Sbjct:    2 ALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPK 132

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Mouse
Match: Psmd14 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 [Source:MGI Symbol;Acc:MGI:1913284])

HSP 1 Score: 123.25 bits (308), Expect = 7.133e-32
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:   31 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSW 225

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Mouse
Match: Brcc3 (BRCA1/BRCA2-containing complex, subunit 3 [Source:MGI Symbol;Acc:MGI:2389572])

HSP 1 Score: 56.6102 bits (135), Expect = 2.830e-9
Identity = 38/134 (28.36%), Postives = 62/134 (46.27%), Query Frame = 1

Query:  202 ALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVAL--PVEGTETRVNAQSEAYEFITMYKDTVAKI-GRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPV---RTVSSGKVNIGAFRT 585
            A L  + HA      EVMG+  G++    ++ + SV +    +  + RV    E     +   + +A++ GR   V+GWYHSHP    W S +DV TQ M Q     FV ++       +   +G+V    F++
Sbjct:   18 AFLVCLNHALSTEKEEVMGLCIGEMDTIRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAELTGRPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQS 151

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. UniProt/SwissProt
Match: sp|Q54PF3|CSN5_DICDI (COP9 signalosome complex subunit 5 OS=Dictyostelium discoideum OX=44689 GN=csn5 PE=1 SV=1)

HSP 1 Score: 392.504 bits (1007), Expect = 3.285e-135
Identity = 189/322 (58.70%), Postives = 245/322 (76.09%), Query Frame = 1

Query:   31 SKRLKMSSLQSWELENNVVTIN-DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEA---SKVSKDAAKLANEELAGLMGQLIKYDV 984
            SK     +L+++ELENN+ TI+ D LF+YD   +   ++SKPW KD HYFK++++SA ALLKMV HAR GG LEVMGML GKV +NTMI+MDS ALPVEGTETRVNAQ EAYE++  Y + + + GR EN +GWYHSHPGYGCWLSGIDV TQ++NQ Y +P++ +V+DP RTVS+GKV IGAFRTYP+ Y PP++GPSEYQSIPL+KIEDFGVHCKQYY L ++YFKSSLD+ +LD LWN+YW +TL+SS I S  DY+     DL+EK+   + +L  S     D ++E    SKVSKD++K+  E++ G+M Q+ K  +
Sbjct:    2 SKNGAADALKTFELENNIQTIDHDQLFKYDPQQYQQFLQSKPWSKDPHYFKHVKISAIALLKMVMHARSGGKLEVMGMLMGKVENNTMIIMDSFALPVEGTETRVNAQVEAYEYMVEYLELIKQTGRLENALGWYHSHPGYGCWLSGIDVGTQSVNQQYSEPWLGIVIDPTRTVSAGKVEIGAFRTYPQGYKPPNEGPSEYQSIPLSKIEDFGVHCKQYYSLEITYFKSSLDQQLLDKLWNKYWVNTLSSSPIFSNRDYITGQINDLSEKLEQAETQLSHSRSSILDKKKEESLLSKVSKDSSKVTIEQVQGIMSQVFKNSI 323

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. UniProt/SwissProt
Match: sp|Q9XZ58|CSN5_DROME (COP9 signalosome complex subunit 5 OS=Drosophila melanogaster OX=7227 GN=CSN5 PE=1 SV=1)

HSP 1 Score: 387.497 bits (994), Expect = 2.706e-133
Identity = 181/312 (58.01%), Postives = 244/312 (78.21%), Query Frame = 1

Query:   49 SSLQSWELENNVVTI--NDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQ-SGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++ ++WELENN+ T+   D++FRYD      I+ +KPW KD H+FK I++SA ALLKMV HAR GG LEVMG++ GKV  NTMIVMD+ ALPVEGTETRVNAQ++AYE++T Y +   ++GR E+ +GWYHSHPGYGCWLSGIDV+TQ +NQTYQ+PFVA+V+DPVRTVS+GKV +GAFRTYP+ Y PP++ PSEYQ+IPLNKIEDFGVHCKQYYPL +SYFKS+LD+ +LD LWN+YW +TL SS +L+  +Y      DL+EK+  ++  L + + +++   E++ SK ++D ++   E + GLM Q++K
Sbjct:    5 AAQKTWELENNIQTLPSCDEIFRYDAEQQRQIIDAKPWEKDPHFFKDIKISALALLKMVMHARSGGTLEVMGLMLGKVEDNTMIVMDAFALPVEGTETRVNAQAQAYEYMTAYMEAAKEVGRMEHAVGWYHSHPGYGCWLSGIDVSTQMLNQTYQEPFVAIVVDPVRTVSAGKVCLGAFRTYPKGYKPPNEEPSEYQTIPLNKIEDFGVHCKQYYPLEISYFKSALDRRLLDSLWNKYWVNTLGSSGLLTNTEYTTGQIMDLSEKLEQSENFLGRGTDVNEKRSEDKLSKATRDCSRSTIELIHGLMAQIVK 316

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. UniProt/SwissProt
Match: sp|Q6P635|CSN5_XENTR (COP9 signalosome complex subunit 5 OS=Xenopus tropicalis OX=8364 GN=cops5 PE=2 SV=1)

HSP 1 Score: 372.474 bits (955), Expect = 3.548e-127
Identity = 182/314 (57.96%), Postives = 238/314 (75.80%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WEL NN+  +   D++++YD      I+ +KPW KD HYFKY +VSA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+  ++ +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:   11 KTWELSNNMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKVSALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 324

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. UniProt/SwissProt
Match: sp|O35864|CSN5_MOUSE (COP9 signalosome complex subunit 5 OS=Mus musculus OX=10090 GN=Cops5 PE=1 SV=3)

HSP 1 Score: 371.318 bits (952), Expect = 9.264e-127
Identity = 182/314 (57.96%), Postives = 237/314 (75.48%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WEL NN+      D++++YD      I+ +KPW KD HYFKY ++SA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+  ++ +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:   11 KTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 324

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BLAST of COP9 signalosome complex subunit 5 vs. UniProt/SwissProt
Match: sp|Q92905|CSN5_HUMAN (COP9 signalosome complex subunit 5 OS=Homo sapiens OX=9606 GN=COPS5 PE=1 SV=4)

HSP 1 Score: 371.318 bits (952), Expect = 9.784e-127
Identity = 182/314 (57.96%), Postives = 237/314 (75.48%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WEL NN+      D++++YD      I+ +KPW KD HYFKY ++SA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+  ++ +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:   11 KTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 324

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BLAST of COP9 signalosome complex subunit 5 vs. TrEMBL
Match: A0A023ZRM9 (COP9 signalosome complex subunit 5 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 513.072 bits (1320), Expect = 0.000e+0
Identity = 255/255 (100.00%), Postives = 255/255 (100.00%), Query Frame = 1

Query:  214 MVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIKY 978
            MVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWTSTLTSSSILSQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIKY
Sbjct:    1 MVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWTSTLTSSSILSQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIKY 255

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. TrEMBL
Match: A0A2H1C396 (Mov34/MPN/PAD-1 family protein OS=Fasciola hepatica OX=6192 GN=D915_11118 PE=4 SV=1)

HSP 1 Score: 441.425 bits (1134), Expect = 1.529e-151
Identity = 209/312 (66.99%), Postives = 255/312 (81.73%), Query Frame = 1

Query:   49 SSLQSWELENNVVTI---NDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            S+  +WE +NNV TI    D+ F+YD+ AH SIV +KPW KD HYFKYI++SA ALLKM+ HAR GGN+E+MG+L GKV H TMIV+DS  LPVEGTETRVNAQ+EAYE++T YK+ VA++GRTENV+GWYHSHPGYGCWLSGIDVTTQ MNQ YQ+PFVA+V+DP+RT+SSGKVN+GAFRTYP  Y PPD+ PSEYQSIP++KIEDFGVHCKQYY L +S+FKS LDK +LD+LWN+YW +TL+S SIL+QPDY+A+LTKDLAEKV      + +       +E+  +K SKDA KLA E+L  LMGQLIK
Sbjct:   38 SAQAAWETDNNVETILGPVDEYFKYDVKAHQSIVNAKPWEKDPHYFKYIKISAVALLKMLIHARSGGNIEIMGVLIGKVAHQTMIVVDSSPLPVEGTETRVNAQAEAYEYMTTYKEVVARVGRTENVLGWYHSHPGYGCWLSGIDVTTQLMNQKYQEPFVAIVIDPIRTISSGKVNLGAFRTYPTGYRPPDESPSEYQSIPMDKIEDFGVHCKQYYALEVSHFKSVLDKRLLDLLWNKYWVNTLSSVSILAQPDYLADLTKDLAEKVEHACSSVLRMNWDNDRLEDRLAKCSKDATKLATEQLHALMGQLIK 349

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BLAST of COP9 signalosome complex subunit 5 vs. TrEMBL
Match: H2KVQ5 (COP9 signalosome complex subunit 5 OS=Clonorchis sinensis OX=79923 GN=CLF_112900 PE=4 SV=1)

HSP 1 Score: 439.113 bits (1128), Expect = 9.137e-151
Identity = 209/312 (66.99%), Postives = 255/312 (81.73%), Query Frame = 1

Query:   49 SSLQSWELENNVVTIN---DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            S+  +W+ +NNV  I    D+ F+YD+ AH SIV +KPW KD HYFK++++SA ALLKM+ HAR GGNLEVMG+L GKV H TMIV+DS  LPVEGTETRVNAQ+EAYE++T YK+ VA++GRTENV+GWYHSHPGYGCWLSGIDVTTQ MNQTYQ+PFVA+V+DP+RT+SSGKVN+GAFRTYP  Y PPD+GPSEYQSIP++KIEDFGVHCKQYY L +S+FKS LDK +LD+LWN+YW +TL+S SIL+QPDY+A LTKDLAEKV  T   + +       +E+  +K  KDA KLA E+L  LMGQLIK
Sbjct:   36 SAQATWDTDNNVEVIMGPVDEYFKYDVKAHQSIVNAKPWEKDPHYFKWLKLSAVALLKMLIHARSGGNLEVMGVLIGKVAHQTMIVVDSTPLPVEGTETRVNAQAEAYEYMTTYKEVVARVGRTENVLGWYHSHPGYGCWLSGIDVTTQLMNQTYQEPFVAIVIDPIRTISSGKVNLGAFRTYPVGYRPPDEGPSEYQSIPMDKIEDFGVHCKQYYSLEVSHFKSVLDKRLLDLLWNKYWVNTLSSVSILAQPDYLAGLTKDLAEKVEHTVASVSRMNWDNDRLEDRLAKCGKDATKLATEQLHALMGQLIK 347

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BLAST of COP9 signalosome complex subunit 5 vs. TrEMBL
Match: A0A4S2L434 (MPN domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_010464 PE=4 SV=1)

HSP 1 Score: 439.113 bits (1128), Expect = 1.188e-150
Identity = 209/312 (66.99%), Postives = 255/312 (81.73%), Query Frame = 1

Query:   49 SSLQSWELENNVVTIN---DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            S+  +W+ +NNV  I    D+ F+YD+ AH SIV +KPW KD HYFK++++SA ALLKM+ HAR GGNLEVMG+L GKV H TMIV+DS  LPVEGTETRVNAQ+EAYE++T YK+ VA++GRTENV+GWYHSHPGYGCWLSGIDVTTQ MNQTYQ+PFVA+V+DP+RT+SSGKVN+GAFRTYP  Y PPD+GPSEYQSIP++KIEDFGVHCKQYY L +S+FKS LDK +LD+LWN+YW +TL+S SIL+QPDY+A LTKDLAEKV  T   + +       +E+  +K  KDA KLA E+L  LMGQLIK
Sbjct:   36 SAQTTWDTDNNVEVIMGPVDEYFKYDVKAHQSIVNAKPWEKDPHYFKWLKLSAVALLKMLIHARSGGNLEVMGVLIGKVAHQTMIVVDSTPLPVEGTETRVNAQAEAYEYMTTYKEVVARVGRTENVLGWYHSHPGYGCWLSGIDVTTQLMNQTYQEPFVAIVIDPIRTISSGKVNLGAFRTYPVGYRPPDEGPSEYQSIPMDKIEDFGVHCKQYYSLEVSHFKSVLDKRLLDLLWNKYWVNTLSSVSILAQPDYLAGLTKDLAEKVEHTVASVSRMNWDNDRLEDRLAKCGKDATKLATEQLHALMGQLIK 347

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. TrEMBL
Match: A0A4Z2DJT8 (COP9 signalosome complex subunit 5 isoform 3 OS=Schistosoma japonicum OX=6182 GN=EWB00_000195 PE=4 SV=1)

HSP 1 Score: 431.409 bits (1108), Expect = 8.527e-148
Identity = 206/312 (66.03%), Postives = 250/312 (80.13%), Query Frame = 1

Query:   49 SSLQSWELENNVVTI---NDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            S+ ++WE ENN+ +I    D+ F+YD+  H SIV +KPW KD HYFK I++SA ALLKM+ HAR GGNLEVMG+L GKV H TMIV+DS  LPVEGTETRVNAQ+EAYE++T YK+ VA++GRTENV+GWYHSHPGYGCWLSGIDV+TQ  NQTYQ+PFVA+V+DP+RT+SSGKVN+GAFRTYP  Y PPD GPSEYQSIP++KIEDFGVHCK YY L +S+FKS LDK +LD LWN+YW +TL+S SIL+QPDY+A LTKDLAEKV      + +       +E+  +K SKDA KLA E+L  L GQLIK
Sbjct:   26 SARETWETENNIESILGPVDEYFKYDVKVHQSIVNAKPWEKDPHYFKCIKISAVALLKMLIHARSGGNLEVMGLLIGKVAHQTMIVVDSSPLPVEGTETRVNAQAEAYEYMTTYKEVVARVGRTENVLGWYHSHPGYGCWLSGIDVSTQLTNQTYQEPFVAIVIDPIRTISSGKVNLGAFRTYPVGYRPPDDGPSEYQSIPMDKIEDFGVHCKHYYSLEVSHFKSVLDKRLLDSLWNKYWVNTLSSVSILAQPDYLAGLTKDLAEKVEHAGSSMSRMNWDNDRLEDRLAKCSKDATKLAMEQLHALTGQLIK 337

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Cavefish
Match: cops5 (COP9 signalosome subunit 5 [Source:NCBI gene;Acc:103038559])

HSP 1 Score: 369.007 bits (946), Expect = 9.338e-127
Identity = 179/314 (57.01%), Postives = 237/314 (75.48%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WEL N++  +   D++++YD      I+ +KPW KD HYFKY ++SA ALLKMV HAR GGNLEVMG++ GKV   TM++MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+   + +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:   11 KTWELSNSIQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMMIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQAEAQLGRGSFMLGLDTHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 324

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Cavefish
Match: cops5 (COP9 signalosome subunit 5 [Source:NCBI gene;Acc:103038559])

HSP 1 Score: 354.369 bits (908), Expect = 1.529e-121
Identity = 171/296 (57.77%), Postives = 226/296 (76.35%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKD 921
            ++WEL N++  +   D++++YD      I+ +KPW KD HYFKY ++SA ALLKMV HAR GGNLEVMG++ GKV   TM++MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+   + +L +         H    E++ +K ++D
Sbjct:   11 KTWELSNSIQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMMIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQAEAQLGRGSFMLGLDTHDRKSEDKLAKATRD 306

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Cavefish
Match: psmd14 (proteasome 26S subunit, non-ATPase 14 [Source:NCBI gene;Acc:103034529])

HSP 1 Score: 123.25 bits (308), Expect = 6.807e-32
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:   31 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINTNMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSW 225

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Cavefish
Match: brcc3 (BRCA1/BRCA2-containing complex subunit 3 [Source:NCBI gene;Acc:103031186])

HSP 1 Score: 63.5438 bits (153), Expect = 4.069e-11
Identity = 46/160 (28.75%), Postives = 73/160 (45.62%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVAL--PVEGTETRVNAQSEAYEFITMYKDTVAKI-GRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPV---RTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPL 645
            + + + A L  + HA      EVMG+  G+V  N ++ + SV +    +  + RV    E     +   + +A++ GR   V+GWYHSHP    W S +DV TQ M Q     FV ++       +   +G+V    F+      S   Q  SEY+ I +
Sbjct:    6 VHLESDAFLVCMNHALSTEKEEVMGLCIGEVDTNRIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLAEMTGRPVRVVGWYHSHPHITVWPSHVDVRTQAMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQ------SVQAQKGSEYERIEI 159

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BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Cavefish
Match: mysm1 (Myb like, SWIRM and MPN domains 1 [Source:NCBI gene;Acc:103027263])

HSP 1 Score: 51.2174 bits (121), Expect = 1.560e-6
Identity = 39/154 (25.32%), Postives = 66/154 (42.86%), Query Frame = 1

Query:  136 IVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVN------AQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTY----QDPFVAVVLDPVRTVSSGKVN 567
            ++  K + +D      + V A AL+ M  HA      EV+G+L G       ++    A P     T +       +Q++A E +           +  NV+GWYHSHP +    S  D+ TQ   Q+Y      PF+ +++ P    ++  V+
Sbjct:  486 LIPCKTFGEDTQEPFQVIVCAEALVVMDVHAHVSMG-EVIGLLGGSYDDEEKVLKICAAEPCNSLSTGLQCEMDPVSQTQASELLG---------AKGHNVVGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAPFIGMIVSPYNPSNTSPVS 629

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006305.1 (pep scaffold:Pmarinus_7.0:GL479573:3013:19927:-1 gene:ENSPMAG00000005669.1 transcript:ENSPMAT00000006305.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 360.533 bits (924), Expect = 5.012e-124
Identity = 180/315 (57.14%), Postives = 239/315 (75.87%), Query Frame = 1

Query:   58 QSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDI-------EEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++WE+ NN+  +   D++++YD      I+ +KPW KD HYFK  +VSA ALLKMV HAR GGNLEVMG++ GKV  +TM++MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+  ++ +L + G     I       E++ +K ++D+ K   E + GLM Q+IK
Sbjct:   21 KTWEMANNMQDLQNVDEIYKYDKKQQQEILAAKPWSKDHHYFKCCKVSALALLKMVMHARSGGNLEVMGLMLGKVDGDTMMIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQIFDLSEKLEQSEAQLGR-GSFLLGIDGPERKPEDKLTKATRDSCKTTIEVIHGLMSQVIK 334

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Sea Lamprey
Match: psmd14 (proteasome 26S subunit, non-ATPase 14 [Source:ZFIN;Acc:ZDB-GENE-070410-56])

HSP 1 Score: 122.479 bits (306), Expect = 2.305e-32
Identity = 77/229 (33.62%), Postives = 121/229 (52.84%), Query Frame = 1

Query:   97 DDLFRYDINAHNSIVKSKPW-VKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            D L R      + + +  P     V   + + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:    2 DRLLRLGAGGMSGLGQGPPSDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINPNMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSISINYRKNELEQKMLLNLHKKSW 226

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Yeast
Match: RRI1 (Catalytic subunit of the COP9 signalosome (CSN) complex; acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling; involved in modulation of genes controlling amino acid and lipid metabolism, and ergosterol biosynthesis [Source:SGD;Acc:S000002375])

HSP 1 Score: 150.984 bits (380), Expect = 4.494e-42
Identity = 70/167 (41.92%), Postives = 107/167 (64.07%), Query Frame = 1

Query:  124 AHNSIVKSK---PWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAK----------IGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRT 585
            + +S++K+K       D+  + ++ +S  +  K+  +A RGGN+E+MG+L G    + ++VMD   LPV GTETRVNAQ E+YE++  Y D +             G   NV+GW+HSHPGY CWLS ID+ TQ +NQ +QDP+VA+V+DP++++    + +GAFRT
Sbjct:   48 SQSSLLKTKLKQQSSTDIPSYTHVLISKLSCEKITHYAVRGGNIEIMGILMGFTLKDNIVVMDCFNLPVVGTETRVNAQLESYEYMVQYIDEMYNHNDGGDGRDYKGAKLNVVGWFHSHPGYDCWLSNIDIQTQDLNQRFQDPYVAIVVDPLKSLEDKILRMGAFRT 214

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Yeast
Match: RPN11 (Metalloprotease subunit of 19S regulatory particle; part of 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000001900])

HSP 1 Score: 117.472 bits (293), Expect = 1.122e-30
Identity = 72/199 (36.18%), Postives = 108/199 (54.27%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPR----HYSPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A  + ++   M  D + + GR + V+GWYHSHPG+GCWLS +DV TQ   +      VAVV+DP+++V  GKV I AFR        +   P Q  S    +    I+   +H   + YY L + Y K++ +  +L  L    W
Sbjct:   27 VYISSIALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVNVVDVFAMPQSGTGVSVEAVDDVFQAKMM--DMLKQTGRDQMVVGWYHSHPGFGCWLSSVDVNTQKSFEQLNSRAVAVVVDPIQSV-KGKVVIDAFRLIDTGALINNLEPRQTTSNTGLLNKANIQAL-IHGLNRHYYSLNIDYHKTAKETKMLMNLHKEQW 221

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Nematostella
Match: EDO44562 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RVE8])

HSP 1 Score: 380.948 bits (977), Expect = 5.824e-132
Identity = 187/315 (59.37%), Postives = 246/315 (78.10%), Query Frame = 1

Query:   52 SLQSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQ-----SGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            +++SWEL NN+  +N  D++F+YD      I+++KPW KD HYFK I++SA ALLKMV HAR GGNLEVMG++ GKV  +TMIVMD+ ALPVEGTETRVNAQ+ AYE++  Y ++   +GR EN IGWYHSHPGYGCWLSGIDV TQ +NQ +Q+PFVA+V+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L +SYFKSSLD+ +LD+LWN+YW +TL+SSS+L+  DY      DL+EK+   + ++ +     +GM +   E + +KV++D++K A E + GLM Q+IK
Sbjct:    6 AMKSWELANNIENVNGIDEIFKYDRQQQQEILQAKPWQKDPHYFKNIKISALALLKMVMHARSGGNLEVMGLMLGKVDGDTMIVMDAFALPVEGTETRVNAQAAAYEYMAAYIESAKSVGRLENAIGWYHSHPGYGCWLSGIDVGTQMVNQQFQEPFVAIVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYSLEVSYFKSSLDRKLLDMLWNKYWVNTLSSSSLLTNADYTNHQIADLSEKLEQAESQVGRMGTFVAGMEERKDEGKLAKVTRDSSKSAIEAVHGLMSQVIK 320

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Nematostella
Match: EDO46281 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQF7])

HSP 1 Score: 123.25 bits (308), Expect = 2.045e-32
Identity = 71/199 (35.68%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHC------KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +     Q P +  S  L  ++   +        + YY + ++Y K+ L++ +L  L  + W
Sbjct:   32 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINPNMMVLGQEPRQTTS-NLGHLQKPSIQAMIHGLNRHYYSISINYRKNELEQKMLLNLHKKTW 226

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Nematostella
Match: EDO35207 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SM50])

HSP 1 Score: 58.9214 bits (141), Expect = 5.426e-10
Identity = 46/167 (27.54%), Postives = 75/167 (44.91%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGK----VTHNTMIVM--------DSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVL-----DPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQ 633
            +++   AL+  +THA      EVMG++ G+    + H   ++M        D V +  E   +  + Q+E    +T  K       R   V+GWYHSHP    W S +D+ TQ M Q   + FV V+      +P  T   G + I  F++   +    + GP +Y+
Sbjct:    6 VKLEGDALMVCLTHALSTEREEVMGLMIGEAEDGIAHVYSVIMLQRLDKRKDRVEISPEQL-SDASTQAERLGLLTPKK-------RPMRVVGWYHSHPHITVWPSHVDLATQAMYQVMDEGFVGVIFSCFNDEPNHT---GSLTITCFQSVDVNK---NNGPPQYK 158

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Medaka
Match: cops5 (COP9 signalosome subunit 5 [Source:NCBI gene;Acc:101155235])

HSP 1 Score: 367.466 bits (942), Expect = 2.694e-126
Identity = 180/317 (56.78%), Postives = 240/317 (75.71%), Query Frame = 1

Query:   49 SSLQSWELENNVVTIN--DDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGM------HKFDIEEEASKVSKDAAKLANEELAGLMGQLIK 975
            ++ ++WEL N++  +   D++++YD      I+ +KPW KD HYFKY ++SA ALLKMV HAR GGNLEVMG++ GKV   TMI+MDS ALPVEGTETRVNAQ+ AYE++  Y +   ++GR EN IGWYHSHPGYGCWLSGIDV+TQ +NQ +Q+PFVAVV+DP RT+S+GKVN+GAFRTYP+ Y PPD+GPSEYQ+IPLNKIEDFGVHCKQYY L ++YFKSSLD+ +L++LWN+YW +TL+SSS+L+  DY      DL+EK+  ++ +L +         H    E++ +K ++D+ K   E + GLM Q+IK
Sbjct:    6 TAQKTWELSNSMQEVQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVTYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNSDYTTGQVFDLSEKLEQSEAQLGRGSFMLGLDTHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIK 322

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Medaka
Match: psmd14 (proteasome 26S subunit, non-ATPase 14 [Source:NCBI gene;Acc:101158838])

HSP 1 Score: 123.25 bits (308), Expect = 6.560e-32
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:   31 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSW 225

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Medaka
Match: psmd14 (proteasome 26S subunit, non-ATPase 14 [Source:NCBI gene;Acc:101158838])

HSP 1 Score: 123.25 bits (308), Expect = 8.008e-32
Identity = 72/199 (36.18%), Postives = 112/199 (56.28%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++ +L  L  + W
Sbjct:   70 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKMLLNLHKKSW 264

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Medaka
Match: psmd14 (proteasome 26S subunit, non-ATPase 14 [Source:NCBI gene;Acc:101158838])

HSP 1 Score: 118.242 bits (295), Expect = 5.858e-30
Identity = 71/196 (36.22%), Postives = 110/196 (56.12%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY----SPPDQGPSEYQSIPLNKIEDFGVHC--KQYYPLVMSYFKSSLDKSILDILWN 750
            + +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    +       P Q  S    +    I+   +H   + YY + ++Y K+ L++    +L N
Sbjct:   31 VYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDINTQQSFEALSERAVAVVVDPIQSV-KGKVVIDAFRLINANMMVLGHEPRQTTSNLGHLNKPSIQAL-IHGLNRHYYSITINYRKNELEQKASLLLSN 222

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Medaka
Match: brcc3 (BRCA1/BRCA2-containing complex, subunit 3 [Source:ZFIN;Acc:ZDB-GENE-100215-1])

HSP 1 Score: 59.6918 bits (143), Expect = 1.259e-9
Identity = 43/160 (26.88%), Postives = 71/160 (44.38%), Query Frame = 1

Query:  184 IRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVAL--PVEGTETRVNAQSEAYEFITMYKDTVAKI-GRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPV---RTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPL 645
            + + + A L  + HA      EVMG+  G+V    ++ + SV +    +  + RV    E     +   + +A + G+   V+GWYHSHP    W S +DV TQ M Q     FV ++       +   +G+V    F+      S   Q  SEY+ + +
Sbjct:   42 VHLESDAFLVCMNHALSTEKEEVMGLCIGEVEEARIVHIHSVIILRRSDKRKDRVEISPEQLSAASTEAERLADLTGKPMRVVGWYHSHPHITVWPSHVDVRTQAMYQMLDQGFVGLIFSCFIEDKNTRTGRVLYTCFQ------SAQAQKGSEYERVEI 195

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Planmine SMEST
Match: SMESG000038057.1 (SMESG000038057.1)

HSP 1 Score: 636.336 bits (1640), Expect = 0.000e+0
Identity = 313/313 (100.00%), Postives = 313/313 (100.00%), Query Frame = 1

Query:   46 MSSLQSWELENNVVTINDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWXXXXXXXXXXXQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIKYDV 984
            MSSLQSWELENNVVTINDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWTSTLTSSSILSQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIKYDV
Sbjct:    1 MSSLQSWELENNVVTINDDLFRYDINAHNSIVKSKPWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWNRYWTSTLTSSSILSQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEEASKVSKDAAKLANEELAGLMGQLIKYDV 313

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Planmine SMEST
Match: SMESG000056198.1 (SMESG000056198.1)

HSP 1 Score: 128.257 bits (321), Expect = 6.738e-34
Identity = 73/201 (36.32%), Postives = 115/201 (57.21%), Query Frame = 1

Query:  178 KYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHC------KQYYPLVMSYFKSSLDKSILDILWNRYW 759
            ++I +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    ++   +Q P +  S  L  ++   +        + YY L + Y K+ L++ +L  L  + W
Sbjct:   30 EHIYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVTVVDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDMNTQQSFEQLSERAVAVVIDPIQSV-KGKVVIDAFRLMNPNHVIANQEPRQTTS-NLGHLQKPSIQALIHGLNRHYYSLPIGYRKNELEQKMLMNLHKKTW 226

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Planmine SMEST
Match: SMESG000056298.1 (SMESG000056298.1)

HSP 1 Score: 122.865 bits (307), Expect = 4.957e-32
Identity = 70/190 (36.84%), Postives = 110/190 (57.89%), Query Frame = 1

Query:  178 KYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHN-TMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHYSPPDQGPSEYQSIPLNKIEDFGVHC------KQYYPLVMSYFKSSLDK 726
            ++I +S+ ALLKM+ H R G  +EVMG++ G+   + T+ V+D  A+P  GT   V A    ++   +  D + + GR E V+GWYHSHPG+GCWLSG+D+ TQ   +   +  VAVV+DP+++V  GKV I AFR    ++   +Q P +  S  L  ++   +        + YY L + Y K+ L++
Sbjct:   30 EHIYISSLALLKMLKHGRAGVPMEVMGLMLGEFVDDYTVTVVDVFAMPQSGTGVSVEAVDPVFQAKML--DMLKQTGRPEMVVGWYHSHPGFGCWLSGVDMNTQQSFEQLSERAVAVVIDPIQSV-KGKVVIDAFRLMNPNHVIANQEPRQTTS-NLGHLQKPSIQALIHGLNRHYYSLPIGYRKNELEQ 215

[Close]

BLAST of COP9 signalosome complex subunit 5 vs. Planmine SMEST
Match: SMESG000061967.1 (SMESG000061967.1)

HSP 1 Score: 49.6766 bits (117), Expect = 2.192e-6
Identity = 33/110 (30.00%), Postives = 55/110 (50.00%), Query Frame = 1

Query:  214 MVTHARRG--GNLEVMGMLFGKVTHNTMIVMDSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGYGCWLSGIDVTTQTMNQTYQDPFVAVVLDP 537
             + HA+     N+E  G+L GK+T   +I+  +VA+P +   T  +  +E  E +  Y D+ + I      +GW H+HP    +LS +D+ TQ   Q      +A+V  P
Sbjct:  211 FLNHAQSNTNKNIETCGILCGKITGGKLIIT-TVAIP-KQIGTSDSCATEFEEELFDYVDSKSLI-----TLGWIHTHPTQTAFLSSVDLHTQLSYQIMLPEAIAIVCSP 313

The following BLAST results are available for this feature:

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Human
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Celegans
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Fly
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Zebrafish
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Xenopus
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Mouse
BLAST of COP9 signalosome complex subunit 5 vs. UniProt/SwissProt
BLAST of COP9 signalosome complex subunit 5 vs. TrEMBL
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Cavefish
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Sea Lamprey
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Yeast
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Nematostella
BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Medaka
BLAST of COP9 signalosome complex subunit 5 vs. Planmine SMEST

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
COPS5	2.037e-127	57.96	COP9 signalosome subunit 5 [Source:HGNC Symbol;Acc...	[more]
COPS5	1.658e-97	72.53	COP9 signalosome subunit 5 [Source:HGNC Symbol;Acc...	[more]
COPS5	7.416e-77	72.85	COP9 signalosome subunit 5 [Source:HGNC Symbol;Acc...	[more]
PSMD14	1.039e-31	36.18	proteasome 26S subunit, non-ATPase 14 [Source:HGNC...	[more]
BRCC3	1.087e-9	28.29	BRCA1/BRCA2-containing complex subunit 3 [Source:H...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
csn-5	1.313e-118	55.56	COP9 signalosome complex subunit 5 [Source:UniPro...	[more]
F37A4.5	4.838e-33	37.38	pep chromosome:WBcel235:III:6711869:6713191:1 gene...	[more]
rpn-11	6.854e-33	31.91	26S proteasome non-ATPase regulatory subunit 14 [...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
CSN5	2.699e-134	58.01	gene:FBgn0027053 transcript:FBtr0083292	[more]
CSN5	3.731e-134	58.20	gene:FBgn0027053 transcript:FBtr0334535	[more]
Rpn11	3.440e-32	36.18	gene:FBgn0028694 transcript:FBtr0079027	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 4


Match Name	E-value	Identity	Description
cops5	2.005e-127	57.28	COP9 signalosome subunit 5 [Source:NCBI gene;Acc:3...	[more]
psmd14	1.501e-31	36.18	proteasome 26S subunit, non-ATPase 14 [Source:ZFIN...	[more]
brcc3	4.808e-11	28.75	BRCA1/BRCA2-containing complex, subunit 3 [Source:...	[more]
brcc3	7.480e-11	28.92	BRCA1/BRCA2-containing complex, subunit 3 [Source:...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cops5	9.159e-128	57.96	COP9 signalosome subunit 5 [Source:NCBI gene;Acc:3...	[more]
cops5	1.262e-127	57.96	COP9 signalosome subunit 5 [Source:NCBI gene;Acc:3...	[more]
prokr2	1.076e-31	36.18	prokineticin receptor 2 [Source:Xenbase;Acc:XB-GEN...	[more]
prokr2	1.222e-31	36.18	prokineticin receptor 2 [Source:Xenbase;Acc:XB-GEN...	[more]
prokr2	2.031e-31	36.18	prokineticin receptor 2 [Source:Xenbase;Acc:XB-GEN...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Cops5	1.324e-127	57.96	COP9 signalosome subunit 5 [Source:MGI Symbol;Acc:...	[more]
Cops5	4.062e-93	73.03	COP9 signalosome subunit 5 [Source:MGI Symbol;Acc:...	[more]
Cops5	1.665e-62	71.76	COP9 signalosome subunit 5 [Source:MGI Symbol;Acc:...	[more]
Psmd14	7.133e-32	36.18	proteasome (prosome, macropain) 26S subunit, non-A...	[more]
Brcc3	2.830e-9	28.36	BRCA1/BRCA2-containing complex, subunit 3 [Source:...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q54PF3\|CSN5_DICDI	3.285e-135	58.70	COP9 signalosome complex subunit 5 OS=Dictyosteliu...	[more]
sp\|Q9XZ58\|CSN5_DROME	2.706e-133	58.01	COP9 signalosome complex subunit 5 OS=Drosophila m...	[more]
sp\|Q6P635\|CSN5_XENTR	3.548e-127	57.96	COP9 signalosome complex subunit 5 OS=Xenopus trop...	[more]
sp\|O35864\|CSN5_MOUSE	9.264e-127	57.96	COP9 signalosome complex subunit 5 OS=Mus musculus...	[more]
sp\|Q92905\|CSN5_HUMAN	9.784e-127	57.96	COP9 signalosome complex subunit 5 OS=Homo sapiens...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A023ZRM9	0.000e+0	100.00	COP9 signalosome complex subunit 5 (Fragment) OS=S...	[more]
A0A2H1C396	1.529e-151	66.99	Mov34/MPN/PAD-1 family protein OS=Fasciola hepatic...	[more]
H2KVQ5	9.137e-151	66.99	COP9 signalosome complex subunit 5 OS=Clonorchis s...	[more]
A0A4S2L434	1.188e-150	66.99	MPN domain-containing protein OS=Opisthorchis feli...	[more]
A0A4Z2DJT8	8.527e-148	66.03	COP9 signalosome complex subunit 5 isoform 3 OS=Sc...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cops5	9.338e-127	57.01	COP9 signalosome subunit 5 [Source:NCBI gene;Acc:1...	[more]
cops5	1.529e-121	57.77	COP9 signalosome subunit 5 [Source:NCBI gene;Acc:1...	[more]
psmd14	6.807e-32	36.18	proteasome 26S subunit, non-ATPase 14 [Source:NCBI...	[more]
brcc3	4.069e-11	28.75	BRCA1/BRCA2-containing complex subunit 3 [Source:N...	[more]
mysm1	1.560e-6	25.32	Myb like, SWIRM and MPN domains 1 [Source:NCBI gen...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000006305.1	5.012e-124	57.14	pep scaffold:Pmarinus_7.0:GL479573:3013:19927:-1 g...	[more]
psmd14	2.305e-32	33.62	proteasome 26S subunit, non-ATPase 14 [Source:ZFIN...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
RRI1	4.494e-42	41.92	Catalytic subunit of the COP9 signalosome (CSN) co...	[more]
RPN11	1.122e-30	36.18	Metalloprotease subunit of 19S regulatory particle...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO44562	5.824e-132	59.37	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO46281	2.045e-32	35.68	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO35207	5.426e-10	27.54	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
cops5	2.694e-126	56.78	COP9 signalosome subunit 5 [Source:NCBI gene;Acc:1...	[more]
psmd14	6.560e-32	36.18	proteasome 26S subunit, non-ATPase 14 [Source:NCBI...	[more]
psmd14	8.008e-32	36.18	proteasome 26S subunit, non-ATPase 14 [Source:NCBI...	[more]
psmd14	5.858e-30	36.22	proteasome 26S subunit, non-ATPase 14 [Source:NCBI...	[more]
brcc3	1.259e-9	26.88	BRCA1/BRCA2-containing complex, subunit 3 [Source:...	[more]

BLAST of COP9 signalosome complex subunit 5 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4


Match Name	E-value	Identity	Description
SMESG000038057.1	0.000e+0	100.00	SMESG000038057.1	[more]
SMESG000056198.1	6.738e-34	36.32	SMESG000056198.1	[more]
SMESG000056298.1	4.957e-32	36.84	SMESG000056298.1	[more]
SMESG000061967.1	2.192e-6	30.00	SMESG000061967.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Cross References

External references for this transcript


Database	Accession
SmedGD GBrowse	SMED30028667
GenBank	AHY82401.1

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30028667 ID=SMED30028667|Name=COP9 signalosome complex subunit 5|organism=Schmidtea mediterranea sexual|type=transcript|length=1150bp
CGAAATCTATATAAGTCTTATATGTTAGCATCTAAACGTTTGAAAATGTC
TAGTCTACAAAGTTGGGAATTGGAAAATAATGTTGTTACAATCAATGATG
ATTTATTTCGTTATGATATAAACGCTCACAACAGTATTGTGAAATCGAAA
CCATGGGTTAAGGACGTACATTATTTTAAATATATACGGGTATCAGCTCA
TGCTTTATTGAAAATGGTTACTCATGCTCGCAGAGGTGGAAATTTGGAAG
TTATGGGAATGCTGTTTGGCAAAGTAACTCATAACACAATGATTGTTATG
GATAGTGTTGCATTACCAGTTGAGGGAACCGAAACTCGCGTTAATGCTCA
ATCTGAAGCGTATGAATTTATTACAATGTATAAAGATACAGTTGCAAAAA
TCGGTCGCACTGAAAACGTTATTGGTTGGTATCATTCACATCCTGGGTAT
GGATGTTGGTTATCTGGAATTGATGTAACAACTCAAACTATGAATCAAAC
TTATCAAGATCCATTTGTGGCGGTTGTTCTCGACCCTGTCCGCACTGTAT
CTTCAGGGAAAGTGAACATTGGCGCATTCAGAACATATCCCCGCCATTAC
TCCCCACCAGATCAAGGCCCGTCTGAGTATCAATCGATTCCTCTTAACAA
AATCGAAGATTTCGGCGTGCATTGCAAGCAATATTACCCGCTTGTCATGT
CGTATTTCAAATCATCGCTCGATAAATCGATATTGGACATATTATGGAAC
CGCTACTGGACCAGCACATTGACGTCATCATCGATTCTCTCTCAGCCCGA
CTACATGGCAGAACTGACGAAAGATCTCGCGGAAAAGGTGGCCAGCACCG
ACCGGAAGTTGTGCCAGTCCGGCATGCACAAATTCGATATCGAGGAGGAA
GCTTCCAAGGTTTCCAAGGACGCAGCCAAATTGGCCAATGAGGAGCTCGC
TGGCTTGATGGGGCAGCTAATCAAATATGATGTTTTCAATCAATAAATTT
TCAATTTCTAATTTAAAATTTTAACTGAAAGAAATATGACCACAAAATTG
AGTATGAATCTTATTAGATATTTTTTCTGATATTAAACATTATCTAAAAT
TTGGACTTTCACTTTCATTAAAAACTATAATTTATGAAAATGACAATAAC

protein sequence of SMED30028667-orf-1

>SMED30028667-orf-1 ID=SMED30028667-orf-1|Name=SMED30028667-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=332bp
RNLYKSYMLASKRLKMSSLQSWELENNVVTINDDLFRYDINAHNSIVKSK
PWVKDVHYFKYIRVSAHALLKMVTHARRGGNLEVMGMLFGKVTHNTMIVM
DSVALPVEGTETRVNAQSEAYEFITMYKDTVAKIGRTENVIGWYHSHPGY
GCWLSGIDVTTQTMNQTYQDPFVAVVLDPVRTVSSGKVNIGAFRTYPRHY
SPPDQGPSEYQSIPLNKIEDFGVHCKQYYPLVMSYFKSSLDKSILDILWN
RYWTSTLTSSSILSQPDYMAELTKDLAEKVASTDRKLCQSGMHKFDIEEE
ASKVSKDAAKLANEELAGLMGQLIKYDVFNQ*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0004222	metalloendopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008237	metallopeptidase activity
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR040961	CSN5_C
IPR037740	CSN5
IPR037518	MPN
IPR000555	JAMM/MPN+_dom

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0008180	COP9 signalosome

Vocabulary: **biological process**
Term	Definition
GO:0006508	proteolysis
GO:0019954	asexual reproduction

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	SMART	SM00232	pad1_6	coord: 53..190 e-value: 2.1E-41 score: 153.5
IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	PFAM	PF01398	JAB	coord: 51..162 e-value: 1.8E-31 score: 108.6
None	No IPR available	GENE3D	G3DSA:3.40.140.10		coord: 6..256 e-value: 5.0E-100 score: 335.9
None	No IPR available	PANTHER	PTHR10410	EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED	coord: 18..322
None	No IPR available	CDD	cd08069	MPN_RPN11_CSN5	coord: 43..307 e-value: 1.81065E-127 score: 363.111
None	No IPR available	SUPERFAMILY	SSF102712	JAB1/MPN domain	coord: 53..190
IPR040961	Cop9 signalosome subunit 5 C-terminal domain	PFAM	PF18323	CSN5_C	coord: 251..322 e-value: 3.1E-9 score: 37.6
IPR037740	COP9 signalosome complex subunit 5	PANTHER	PTHR10410:SF6	COP9 SIGNALOSOME COMPLEX SUBUNIT 5	coord: 18..322
IPR037518	MPN domain	PROSITE	PS50249	MPN	coord: 54..191 score: 32.805