FMRFamide-activated amiloride-sensitive sodium channel

Query:  862 GLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNT--PTKPCVERDDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTVIEDRISCIGDIVSDADYQKELERTI-------CFPRCDILTFESTIS 1320
            G +V+VH     P ++  G  V  G+   I  +P+    + T    K  V R       DL       +KNC L  + +L+++ C C+    PR I+P   +  CG   NDN     DR+            Q E+E ++       C+P C  LT+ +T+S
Sbjct:  285 GFKVLVHNPAELPKVSNYGFVVTAGREARIPIEPVYEDALPTIRSIKKSVRRCLFSDENDLAYYRTYSRKNCELECEAKLLLRECSCVLYYLPR-IDPLARV--CGP--NDN--QCTDRV------------QTEIESSLTNLSCENCWPGCFELTYRATLS 427          

Query:  538 YLDTMSMYYQNLQMNESFMIGHDKETY-LTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYR-----EHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDLDQTFMSDK--KNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTVIEDRISC---IGDIVSDADYQKELERTICFPRCDILTFESTISITKW---GATAW 1347
            YL  +S  + N+ + +   +G   E   LTC+   G        CS     +F R+   +Y NC+ F       ++  E  + + S  P  D+      + EQ   +   Q     R+++H+  SFP +   G++  PG    I     Q + +  P   C      +  ++L   F S    ++C+    QE +++ C C    +P P        YC    ND +    D + C   + D V+D    +E   ++C   C+   ++  IS+  W   GA  W
Sbjct:  237 YLLQLSSIFSNVPLADRIAMGFKAEDLILTCL--FG-----GQPCSY---RNFTRIYDADYGNCYIF-------NWGQEGEDPMASANPGADFGLKLVLDIEQGEYLPYVQTTAAARLILHQQRSFPFVKDLGIYAMPGTETSIAVLVDQLEHMEAPYSSCTVNGSDIPVQNLYAEFNSSYSIQSCLRSCYQEQMVQTCGCADYQYPLPNGSE----YC---SNDKY---PDWVPCYYGLRDSVAD----RESCISLCQQPCNDTQYKMVISMADWPSAGAQDW 489          

Query:  373 FPALTICHHHPFSIKAHDLWNRSIVMSPAKYN--RYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTF---QPENINVSYLFESINIVVSLE---PKPDYREHEQAFIVETFQ----RAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQN-----------DNFTVIEDRISCIGDIVS-DADYQKEL--ERTI-----CFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXTRVTETKGYKMWLDYANKENLSDVESTKVNHFLQGENFAYVVLQRKSKNTVIKQEKLVTTPYV------------------LLSRIGGVCSLTIGLTAAFVVEFIEFIYRF 1692
            +P+++IC+  P S++      R +  +    N   +LR +    F+++        S+++++  +Y+NL        G D +     +  +  +  F  +   + N  F       YFNC TF   Q   ++ +     ++++ S+E   P P        + V  F      + G+RVVVH  GS P     G+ + PG  + +  + I H R+  P   C   D L   K    TF +    C+ L KQ LI++ C C   + P    P+ +  +CG I++           D+    EDR       ++ +   QK L  +RT      CF  C   ++  ++S++ W    + L  +    K       N    T       Y   L + ++++L+  +S   +   +  + +   + +++ + +I+Q  L    Y+                  L + IGG   L +G++   ++E IE + R 
Sbjct:  111 YPSVSICNIEPISLRT----IRRMYFNNESQNLITWLRFIQKFRFEQD--------SFMNSIRAFYENL--------GQDAKKLSHNLEDMLMHCRFNRELCHVSN--FSTFFDGNYFNCFTFNSGQRLQMHATGPENGLSLIFSVEKDDPLPG------TYGVYNFDNNILHSAGVRVVVHAPGSMPSPVDHGIDIPPGYSSSVGLKAILHTRLPYPYGNCTN-DMLNGIKQYKYTFFA----CLQLCKQRLIIQRCGCKSSALPE--VPSYNATFCGVIKDWQEINRNHSNEDHNQSEEDRAFIPTPYLACEEREQKNLNNDRTYELSCGCFQPCSETSYLKSVSLSYWPLEFYQLSAVERFFKQERQAGQNHFMKTAYE----YLEKLAHPSQKHLARNDSHMDDILSKSYSLSEKEMAKEASD-LIRQNMLRLNIYLEDLSVVEYRQLPAYGLADLFADIGGTLGLWMGISVLTIMELIELVIRL 559          

Query:  358 DSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPC--------VERDDLM--------------TFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTVIEDR---ISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXTRV---TETKGYKMWLDYANKENLSDVESTKVNHF-LQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRFCNHSNEEKQFCQNRISTKSDRNLRKISAELNLNSIENKMNK 1815
            D+ S FPALT+CHHHPFS +A++LW    VMSP  +NR +R ++     +NQ    +     D++S+YYQN+   ++F +GH+   +L CM + G ++  ED+C  L      R S H YFNCHTF+P N   S   E++ ++VSL PKP+Y + EQAF+V+ F+ A GLRVVVHE G++P++ ++GLHVEPGK+NEI YQP+  +R+NTP  PC        VE+  ++               + DLD  +   +  CILL +Q  IMK C C ++  PRP  P    PYCG I  D  +V ED+   ISC+ +++ ++D ++  E T+C+PRC+   +ESTIS+T W A  W L+W+R  N+A   ++   +         ++KGYK WL+Y  KENL+ +    +    LQG NFAYVVL+R+S +  + +EKLV +  VLLSRIGG+CSLTIGLTA F VE IEF Y  C  +  E +    R+   +DR+      E  LN  E  +NK
Sbjct:   71 DAQSPFPALTVCHHHPFSSRAYELWRNHAVMSPTDFNRQMRNLTQRFLDENQLDAATAMYNYDSISIYYQNILPEDAFRLGHNSSIFLNCMWRNGQHMQVEDNCLNLEGIRVRRFSHHIYFNCHTFEPINDTFSNSTETLALIVSLGPKPNYDKQEQAFLVDLFEMARGLRVVVHEPGTYPNLEKEGLHVEPGKLNEINYQPVLWERLNTPPHPCRSKKQDQSVEKARIILANMTPSTDPTYAYAYMDLDVPYRYTQSQCILLHQQMDIMKKCHCQYIFNPRPAHPYHHTPYCGSILKDETSVPEDQRKNISCVQELL-ESDQKQAYETTVCYPRCNHYNYESTISVTTWRAVDWQLHWLRHLNRAFKRMEQERDATKEQWDRAQSKGYKDWLEYFQKENLTSIPENAIKDLNLQGNNFAYVVLKRRSGDVRVNREKLVLSISVLLSRIGGLCSLTIGLTAGFAVEIIEFAYVLC--TQRESKNTNGRLDC-TDRD-----QEYGLNCSETLLNK 576          

Query:  358 DSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPC--------VERDDLM--------------TFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTVIEDR---ISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXTR---VTETKGYKMWLDYANKENLSDVESTKVNHF-LQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRFCNHSNEEKQFCQNRISTKSDRNLRKISAELNLNSIENKMNK 1815
            D+ S FPALT+CHHHPFS +A++LW    V+SP  +NR +R ++     +NQ    +     D++S+YYQN+   ++F +GH+   +L CM + G ++  ED+C  L      R S H YFNCHTF+P N   S   E++ ++VSL PKP+Y + EQAF+V+ F+ A GLRVVVHE G++P++ ++GLHVEPGK+NEI YQP+  +R+NTP  PC        VE+  ++               + DLD  +   +  CILL +Q  IMK C C ++  PRP  P    PYCG I  D  +V ED+   ISC+ +++ ++D ++  E T+C+PRC+   +ESTIS+T W A  W L+W+R  N+A   ++   +         ++KGYK WL+Y  KENL+ +    +    LQG NFAYVVL+R+S +  + +EKLV +  VLLSRIGG+CSLTIGLTA F VE IEF Y  C  +  E +    R+   +DR+      E  LN  E  +NK
Sbjct:   71 DAQSPFPALTVCHHHPFSSRAYELWRNHAVISPTDFNRQMRNLTQRFLDENQLDAATAMYNYDSISIYYQNILPEDAFRLGHNSSIFLNCMWRNGQHMQVEDNCLNLEGIRVRRFSHHIYFNCHTFEPINDTFSNSTETLALIVSLGPKPNYDKQEQAFLVDLFEMARGLRVVVHEPGTYPNLEKEGLHVEPGKLNEINYQPVLWERLNTPPHPCRSKKQDQSVEKARIILANMTPSTDPTYAYAYMDLDVPYRYTQSQCILLHQQMDIMKKCHCQYIFNPRPAHPYHHTPYCGSILKDETSVPEDQRKNISCVQELL-ESDQKQAYETTVCYPRCNHYNYESTISVTTWRAVDWQLHWLRHLNRAFKRMEQERDATKEQWDRAQSKGYKDWLEYFQKENLTSIPENAIKDLNLQGNNFAYVVLKRRSGDVRVNREKLVLSISVLLSRIGGLCSLTIGLTAGFAVEIIEFAYVLC--TQRESKNTNGRLDC-TDRD-----QEYGLNCSETLLNK 576          

Query:  343 SYNFH---DSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDY-REHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVER-----DDLMT-----------------FKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTV--IEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXTR---VTETKGYKMWLDYANKENLSDVESTKVNHF-LQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRF 1692
            S N H   D+ S FPALTICHH PFS  A+ LW    VMSP+ +N+++R +++     N           D++S+YYQN++  +++ +GHD   +L CM ++   +  ED+C  +      + S H YFNCHTF+P+    +Y  ++I ++VSL    +Y  +HEQAF+V+ F+ A GLRVVVHE G++PD+ ++GLHVEPGK+NEI YQP+  KR+NTP  PC E       DL T                 + DL+ ++   +  CIL  +QE I+K C C ++  PRP  P+ +LPYCG I   +F +  +  RI C+     +   +++ E T+C PRC   T+ESTIS+T W A  W L+W+R+ N+A  L++ +V        +T++KG++ W +Y  K+NL+++ S  +N   L G+NFAYVVL+R++ +  + QEKLV +  VLLSRIGG+CSL+IGLTAAF+VE IEF YR 
Sbjct:  102 SVNIHVALDTKSPFPALTICHHQPFSQNAYYLWRNDDVMSPSIFNKHMRNLTHTFLIDNDVDTAETLYQYDSLSIYYQNIKAIDAYRLGHDTTVFLNCMRRVNQTMQIEDNCMHMDGFQIRKFSHHIYFNCHTFEPKTKIDAYDTDTIALIVSLGIDVNYDNQHEQAFLVDLFEMARGLRVVVHEPGTYPDLEREGLHVEPGKLNEINYQPVLWKRLNTPQNPCREEFIDRNPDLATITKYKLSQLTGLDFAYAYNDLNVSYRYTQSQCILFHQQEDIIKECGCQYIYNPRPQYPSSNLPYCGSILEGDFDIMALAKRIQCLTSGPLNVTIRRQYETTLCHPRCRYYTYESTISVTTWRAVDWQLHWLRQLNRAFKLMQHDVKINGEYWNITQSKGFQQWNEYYKKDNLTNISSNAINDLNLHGDNFAYVVLKRRASDVRVSQEKLVLSISVLLSRIGGLCSLSIGLTAAFIVELIEFAYRL 583          

Query:  286 ISTVALVVI--CLDNDDWAYS-SYNFH---DSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPC----VER------------------DDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTV--IEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXTR---VTETKGYKMWLDYANKENLSDVESTKVNHF----LQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRFC 1695
            I TV L++    L  D   Y  S N H   D+ S FPALTICHHHPFS  A+ LW    VMSP+ +N+++R +++     N           D++S+YYQNL+  +++ +GHD   +L CM ++   +  ED+C  +      + S H YFNCHTF+P+    +   ++I ++VSL   P+Y   EQAF+V+ F+ A GLRVVVHE G++PD+ ++GLHVEPGK+NEI YQP+  KR+NTP  PC    ++R                  D    + DL+ ++   +  CIL  +Q+ I+K C C ++  PRP  P+ +LPYCG I   +F +  +  RI C+     +   + + E T+C PRC   T+ESTIS+T W A  W L+W+R+ N+A   ++ +V        +T++ G+  W D  N+ +LS+     VN      LQG+NFAYVVL+R++ +  + QEKLV +  VLLSRIGG+CSL+IGLTAAF+VE IEF YR  
Sbjct:   80 IMTVGLLLTTYLLVQDYLVYDVSVNIHVELDAKSPFPALTICHHHPFSQNAYHLWRNGDVMSPSIFNKHMRNLTHKFLMDNDVDAAETLYQYDSLSIYYQNLKAIDAYRLGHDTTAFLNCMRRVNHTMQIEDNCMHMDGFQIRKFSHHTYFNCHTFEPKTKVEAEDTDTIALIVSLGTDPNYSNQEQAFLVDLFEMARGLRVVVHEPGTYPDLEREGLHVEPGKLNEINYQPVLWKRLNTPQNPCRAEFIDRNPELASITDHKLPRLTGLDFAYAYNDLNVSYRYTQSQCILFHQQKDIIKECGCQYIYNPRPQYPSSNLPYCGSILEGDFDILALAKRIQCLTSGPLNVTVKSQYESTLCHPRCRYYTYESTISVTTWRAVDWQLHWLRQLNRAFKSMQYDVKINGEDWNITQSNGFHRWKDIENELSLSNDFQISVNAINDLNLQGDNFAYVVLKRRASDVRVSQEKLVLSISVLLSRIGGLCSLSIGLTAAFIVELIEFTYRLA 586          

Query:  358 DSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPC----VER------------------DDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKI--QNDNFTVIEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXT---RVTETKGYKMWLDYANKENLSDVESTKVNHF-LQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRFCNHSNEEKQFCQNRISTKSDRNLRKISAELNLNSIENKMNKSETQIQTNLSNSKLPTADSFN 1878
            D++S FPALT+CHHHPFS +A+ LW  + V+SP+ +NR +RK++    ++N     S     D+MS+YYQNL   +++ +GHD   +L CM ++   +  EDDC+K+      + S H +FNCHT +P +   +   ++I +VV L P PDY + EQAF+++ ++ A+GLRVVVHE G++PD+ ++GLHVEPGK+NEI YQPI  +R+NTP  PC    V+R                  D    + DL+ ++   +  CI L  Q  I+  C C ++  PRP  P+ ++PYCG    + D    +  RI C+     +   ++    T CFP C+  ++EST+S+T W    W L+W+R  N A   ++           VT++ GY  W +Y + +NL+++ +  +    L+G NFAYVVL+R+S++  I +EKLV +  VLLSRIGG+CSLTIGLTAAFVVE +EF Y  C    +      +    KS      I+ E   N I    + S+  ++++ +N    TAD + 
Sbjct:   71 DAHSPFPALTVCHHHPFSAEAYRLWRENKVLSPSAFNREMRKLTQYHLERNNLDISSNLYQYDSMSIYYQNLNTEDAYRLGHDTSIFLNCMRRVNQAMQIEDDCTKMDGFRIRKFSHHTFFNCHTIEPTDKMEAEATDTIALVVGLGPTPDYSDEEQAFLMDLYEMAQGLRVVVHEPGAYPDLEREGLHVEPGKLNEINYQPIHWQRLNTPRHPCRTERVDRTHELASITSDRLPKSPSSDYAYAYTDLNVSYRYTQSQCIHLYMQLNIIDKCHCQYIYNPRPKHPSKEVPYCGSFLYEQDKTLALSKRIECLNAGPMNTSLKRIHAATKCFPLCNYYSYESTMSVTTWRTENWQLHWLRHLNNAFQAMQREQEEKGPDFNVTKSAGYARWKEYLDSQNLTNIPTNDLKKLNLEGSNFAYVVLRRRSQDLQINKEKLVLSISVLLSRIGGLCSLTIGLTAAFVVELVEFTYLLCTDQGQSANKPPDLAPMKS-----PITMEAP-NPIVTNYDHSDCLLKSDPTNCGRITADQYG 599          

Query:  823 EQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDL------DQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTVIEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHL----YWIRETXXXXXXXXXXXXXXTRVTETKGYKMWLDYANKENLSDVESTKVNHFLQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFI-YRFCNHSNEEKQF 1722
            EQ   +E      G++V + + G  P   Q G+ + PG+   I+   +Q +R++       E  + M+ K+L        + M+ K +C+  +K E      +C   ++  P     ++P C ++   N T+I D ++   D   D    +E     C P C  ++F+ T+S  +W A ++ +    Y++R                 RV                 L+ + S+   +F+  EN A V +     + ++ QE L  T   LLS IGG   + IG++A    E IE +     N SN  K+ 
Sbjct:  237 EQNEYLEGITEVAGMKVTISDQGVLPFPGQQGIRIMPGQSTGIQMTKLQTRRIDPFKNRSCESSNEMSDKNLFFGYNMTYSIMACKYSCLNARKIE------RCGCTNYNTPEMQKRNIPLCNRL---NSTII-DCLNKAYDTFEDGSCDRE-----CPPSCSEVSFDLTVSSARWPARSFEVTKYAYFLR----------------VRV-----------------LNKIASSSSKYFVNSENIAQVHVYYGELDYLLVQETLAYTFMSLLSDIGGQMGMWIGISALTCAELIELVCVILANMSNRSKKI 499          

Query:  286 ISTVALVVICLDNDDWAYSSYNFHDSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTVIEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXTRVTETKGYKMWLDYANKENLSDVESTKVNHFLQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRFCNHSNEEKQFCQNRISTKSDRNLRKISAELNLNSIENKMNKSETQIQTNLSNSKLPTADSFNLVITE 1893
            ++T  +V+  L  D   Y+     DSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTVIEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETNKALNLLKANVNN+TRVTETKGYKMWLDYANKENLSDVESTKVNHFLQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRFCNHSNEEKQFCQNRISTKSDRNLRKISAELNLNSIENKMNKSETQIQTNLSNSKLPTADSFNLVITE
Sbjct:  106 VATTFMVLEFLQYDVNVYTKI-ILDSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTVIEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETNKALNLLKANVNNSTRVTETKGYKMWLDYANKENLSDVESTKVNHFLQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRFCNHSNEEKQFCQNRISTKSDRNLRKISAELNLNSIENKMNKSETQIQTNLSNSKLPTADSFNLVITE 640          

Query:   26 MENDPEPCAIKLINIKKSQMNSESKLEGPNVSFKVNKKRNLLMRYSWRRKDSVQSQRKKKASISHIFYLFCTTTSIRGMNKVPKGPIFLRLLWLSFVLIMTTGLTVATTFMTVIPLFQLLQFVI 397
            MENDPEPCAIKLINIKKSQMNSESKLEGPNVSFKVNKKRNLLMRYSWRRKDSVQSQRKKK+SISHIFYLFCTTTSIRGMNKVPKGPIFLRLLWLSFVLIMTTGLTVATTFM    + + LQ+ +
Sbjct:    1 MENDPEPCAIKLINIKKSQMNSESKLEGPNVSFKVNKKRNLLMRYSWRRKDSVQSQRKKKSSISHIFYLFCTTTSIRGMNKVPKGPIFLRLLWLSFVLIMTTGLTVATTFM----VLEFLQYDV 120          

Query:  286 ISTVALVVICLDNDDWAYSSYNFH-----DSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQND-NFTVIEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRE--TXXXXXXXXXXXXXXTRVTETKGYKMWLDYANKENLSDVESTKVNHF-LQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRFCNHSNEEKQFCQNRISTKSDRNLRKISAELNLN 1791
            +S + +   CL   D+     N +     DS + FPALT+CHHHPFS + + +W     MSP+ +NR +R ++ D    N        SY D +S+YYQNL   ++  +GH+   +LTCM  L   I F ++C+KL       LS HE+FNC+TF+P   +VS   + + I+VSL P+P + + EQ+FI++TF++A+GL+V+VHE+G+ PDI + GLHVEPGKMNEI Y+P Q +  NTP KPC+     + + DL  T+   K  C+   +QE IM  C C+F+  PRP+ P   +PYCG I  D N + I   + C+ D+++    +++ E+  CF RC+ +TF+STISITKW AT WHLYW+R+  T+          N    VTE++ +K WL Y NK++L      K N F L+ +NFAY+VL+R+SK++V K E+LV T YVL+SRIGG+CSLT+G+T AF+VE +EF Y F     E+++    R  + S  N++ IS +   N
Sbjct:   94 MSAILITSSCLLVRDFMLYDVNINTKLEIDSMTPFPALTVCHHHPFSHRGYRMWKSGKAMSPSYFNRKMRNLTLDQLLLNDVESAETISYYDGISIYYQNLPYEQAIQMGHNSSIFLTCMYLLENQIYFAENCTKLEFYRIKLLSHHEHFNCYTFEPTQPHVSSNLDMLGIIVSLGPEPKHFDMEQSFIIDTFRQAQGLKVIVHESGTLPDIDEAGLHVEPGKMNEIIYRPNQWQLTNTPAKPCINDTSRIAYVDLANTYNYTKHLCLKYAEQEDIMNQCHCMFIYNPRPMMPNESMPYCGSILKDFNLSNIYSYVKCLSDVLNQKSKRQQWEKEKCFHRCNYMTFDSTISITKWRATEWHLYWLRQQITSLGEMKQFLKANPNRNVTESQAFKTWLIYGNKKDLRKT-GLKANEFLLKDDNFAYIVLRRESKDSVKKYERLVITQYVLVSRIGGLCSLTVGITLAFIVELVEFCYLFSAKETEKRK----RKYSNSVENVKLISTQQETN 599          

Query:  197 KKKASISHIFYLFCTTTSIRGMNKVPKGPIFLRLLWLSFVLIMTTGLTVATTFM 358
            KK     + F LFC+T SIRG+NK+ KGP  LRLLWL FVLIM+  L  ++  +
Sbjct:   52 KKDFQPKNFFILFCSTISIRGINKIIKGPRPLRLLWLCFVLIMSAILITSSCLL 105          

Query:  286 ISTVALVVICLDNDDWAYSSYNFH-----DSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSNDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGK-IQNDNFTVIEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXTRVTETKGYKMWLDYANKENLSDVESTKVNHFLQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIYRFCNHSNEEK-QFCQNRISTKSDRNLRKISAELNLNSIENKMNKSETQIQTNLSNSKLPTADSFNLVITE*SLDHLDLLVL 1926
            +STV +V  CL   D+     N +      S + FP++TICHHHPFS++A+  W  + ++SP+ +NR +R +++ +   N+       S  D +S+YYQN+  N+S +IGH K+ +L+CM      I++E++CSKL        S HE+FNC+TF+ +   ++    ++ I+VS+ P PDY   EQAFIV+TF++A+GL+V+VHE G  PDI   G+HVEPGK+NEI Y+P++ K  NTPTKPC        + DL++ +   +  C+  ++Q+ I+  C CIF+  PR   PT  LPYCG  +++ + + +  RI C+ +I  D +++K+LE   CF RC  +T+E++ISITKW AT WHL+WIR   + L   +   N     TE+  +K WL Y N  NL+ ++  +   FL  +NFAY+VL+R+S N+V K E+LV +PYVL+SRIGG+CS T+G+TA+F VE +EF+Y +   +   K +  ++ I  K+  + +++  + +L  I N  NK    ++    +   PT D   L ++  S D +  ++L
Sbjct:  112 MSTVLIVSSCLLVRDFMLYDVNINIEVRLASQTPFPSITICHHHPFSMEAYKYWRENKILSPSTFNRKMRNLTHSNLMGNRVMEAEGISNYDVISVYYQNIGYNDSMLIGHQKDIFLSCMLLRNNMISYEENCSKLEEYEVKMFSHHEHFNCYTFEAKVDKIT----TLGIIVSMGPPPDYSATEQAFIVDTFRQAQGLKVIVHEPGVPPDIDNGGVHVEPGKLNEISYRPVEWKLENTPTKPCFNDIKKERYNDLERFYNYTQDMCLSSEEQKRIIDECHCIFIYNPRLQIPTKKLPYCGNFLEDSDLSELNHRIECLTNIQEDVNFKKKLESEKCFQRCTYMTYETSISITKWRATEWHLHWIR--LQLLTFRQLKNNPQINATESTYFKQWLKYWNATNLTVIDEDRKERFLANDNFAYIVLRRESDNSVRKYERLVISPYVLVSRIGGLCSFTVGITASFFVEILEFLYLYYQSNKTSKLEKSEDNIYEKTQFSPKRVLKKSSLKKIPNTKNKPNL-LKCEFKDFSEPTHDVKKLDLSNNSSDQIREILL 658          

Query:  191 QRKKKASISHIFYLFCTTTSIRGMNKVPKGPIFLRLLWLSFVLIMTTGLTVATTFM 358
             R +     ++F LFC+TTS++GMNK+ +GP  LR LWLSFV+ M+T L V++  +
Sbjct:   68 DRLRNPKTKNVFILFCSTTSMKGMNKITRGPKPLRFLWLSFVMTMSTVLIVSSCLL 123          

Query:  364 NSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMS------NDSFQKNQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSL-EPKPDYREHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCG----KIQNDNFTVIEDRISCIGDIVSDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXTRVTETKGYKMWLDYANKENLSDVESTKVNHFLQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIY 1686
            NS+FPA+TICHHHPFS  A+ LW+   V+SP+ +N Y+R+ +      +D F  N Y       Y D++ +YYQNL  NES  +GH     L C+ +  + I+FE+DC +  +    RLS  ++FNC+TF+P NI+VS      +++VSL  P+PDY  HEQAF+++ F++A+GLR VVHE G+ PDI ++GLHVEPGK+NEI +QP+ + +++TP +PC+  ++     DLD  +       I L+KQ LI+K+CKC+++ +PRP+ PT ++PYCG    KI  D FT    RI+C+ + +      +E+E+  C PRC   T+E+T+SITKW A  W L+W+   + A   L AN++  +       +K +L+  +  N++  +S K  + L G++FAYVVL++KS     + EK V +  VLLSRIGG CSL IGLT A VVEFIEF+Y
Sbjct:  106 NSTFPAITICHHHPFSKDAYKLWDSKKVLSPSLFNLYMRQNALHYLNQDDKFANNFY-------YFDSIDIYYQNLLYNESIALGHKYTIVLYCLRRNDYQIDFENDCQQFDSYVIKRLSHPQHFNCYTFEPRNISVSVSTRFFSLIVSLGRPEPDYANHEQAFLIDVFEQAKGLRAVVHEPGTIPDIEREGLHVEPGKLNEINFQPVLNLKLDTPKRPCIPDNESSKLIDLDSKYNYTFYEYINLEKQYLIVKHCKCMYILYPRPLYPTKEVPYCGKLWPKIDLDEFTT---RINCVSNYLK-MSLTEEIEKK-CRPRCSYYTYEATVSITKWRAKQWQLHWLSLQSNAQKALNANISAESYQNAKNSWKSYLERRDLSNVNIADSRKSLN-LDGDDFAYVVLKKKSSILKERSEKEVLSLPVLLSRIGGFCSLLIGLTVAVVVEFIEFVY 544          

Query:  325 DDWAYS----SYNFHDSNSSFPALTICHHHPFSIKAHDLWNRSIVMSPAKYNRYLRKMSN---DSFQK-----NQYGHGSVSSYLDTMSMYYQNLQMNESFMIGHDKETYLTCMNQLGFNINFEDDCSKLFNTSFHRLSLHEYFNCHTFQPENINVSYLFESINIVVSLEPKPDYR-EHEQAFIVETFQRAEGLRVVVHETGSFPDIAQDGLHVEPGKMNEIKYQPIQHKRVNTPTKPCVERDDLMTFKDLDQTFMSDKKNCILLKKQELIMKNCKCIFVSFPRPIEPTLDLPYCGKIQNDNFTVIEDRISCIGDIV-SDADYQKELERTICFPRCDILTFESTISITKWGATAWHLYWIRETXXXXXXXXXXXXXXTRVTETKGYKMWLD------------YANKENLSDVESTKVNHFLQGENFAYVVLQRKSKNTVIKQEKLVTTPYVLLSRIGGVCSLTIGLTAAFVVEFIEFIY 1686
            D W YS    +Y   D+ ++FPA+T C+H PFS+ A++LW+   VMSP ++N+ LR +S+   D  +K     N       ++ +D MS+YYQ+L+   S  +GH++  +  CM   G  + F + C         R S   YFNC+T +P    V+     I  ++ L P  D    H+Q F+V+ F++A GLRV VHE GS+P+I Q G  +EPG++NE+ +QP+ + RVN+PTK C + +  +T++DL   F  DK+ C+  + Q+++++ C C++  +PR   P     YCG +   N   I D ++C+G  + S +  +  LE++ C  RC  + ++  +S+TKW  T W LYW++  N+     +  +   T  + T+  K  L+            + N+ NLS    ++ +  + G+ +++VV++R+  NT +K+E+ V T   L+SRIGG+ SL IGLT AF  E IE+ Y
Sbjct:   57 DYWQYSVNIQTYTRFDNGTAFPAVTFCNHQPFSLTAYNLWSSGQVMSPTEFNKKLRHLSSKYLDELEKTPTVENMMKPLLWTTVMDRMSIYYQSLEPEVSAQLGHNQSMFHHCMWWYGKQMAFGESCKDDM-LVVKRFSHPSYFNCYTVEPIK-QVAMDISRIGAIIWLGPNEDIDIRHKQGFLVDIFEQAYGLRVAVHEAGSYPNIDQMGRQIEPGRLNELNFQPVLNLRVNSPTKKCND-NPTVTYQDLGVDFNYDKELCLNYEIQKVVVEKCGCLYGYYPRYFFPNKTHNYCGHLNFTNDKSIIDNLNCLGKYMDSSSGLKANLEKS-CLLRCRNIDYDLAVSVTKWRPTEWQLYWLKHVNQHFQRYEDVLTKYTDKSTTEKEKSTLELQMKSHLEYFKKFLNQANLSRHSDSENSQSIFGDRYSFVVVKRRDNNTFVKEERFVLTFSALISRIGGLSSLYIGLTFAFFAEVIEYFY 532