Protein kinase domain-containing protein

Overview
NameProtein kinase domain-containing protein
Smed IDSMED30028483
Length (bp)1913
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Protein kinase domain-containing protein (SMED30028483) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30028483) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase domain-containing protein (SMED30028483) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase domain-containing protein (SMED30028483) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30028483

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 11

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30028483h1SMcG0008963 Contig702uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30028483h1SMcG0008963 Contig702newmark_estsPMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
cephalic gangliaSMED30028483h1SMcG0008963 dd_Smed_v4_9652_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30028483h1SMcG0008963 dd_Smed_v4_9652_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30028483h1SMcG0008963 dd_Smed_v4_7746_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30028483h1SMcG0008963 dd_Smed_v4_7746_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30028483h1SMcG0008963 dd_Smed_v4_7746_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30028483h1SMcG0008963 Contig35475newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30028483h1SMcG0008963 Contig35475uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
tail regionSMED30028483h1SMcG0008963 dd_Smed_v6_7746_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
tail regionSMED30028483h1SMcG0008963 dd_Smed_v6_11611_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K4 (mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6856])

HSP 1 Score: 157.532 bits (397), Expect = 2.158e-39
Identity = 102/291 (35.05%), Postives = 150/291 (51.55%), Query Frame = 2
Query:  788 SMMGLECKPPFCNHRLCKTSLKNKTF--AKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAV-TTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +++G  C  P     +    L+  TF   +G++IG G +G +Y C       + A+K I       K I+E  +       + H  ++RYFG    ++ + IFMEY  +G+LE   E  R    +++IR YSKQI   +  LH + I+HRDIK ANI +     IKL DFG S  L      +   V +T+GT  + APEVI T   G  +  +ADIWS+G  VI M+TG+ P++ Y H F ++ ++    K  +PE   +S   K F+   L  DP  R TA+QLL   F
Sbjct: 1266 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE---EVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1550          
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K4 (mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6856])

HSP 1 Score: 157.147 bits (396), Expect = 2.695e-39
Identity = 102/291 (35.05%), Postives = 150/291 (51.55%), Query Frame = 2
Query:  788 SMMGLECKPPFCNHRLCKTSLKNKTF--AKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAV-TTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +++G  C  P     +    L+  TF   +G++IG G +G +Y C       + A+K I       K I+E  +       + H  ++RYFG    ++ + IFMEY  +G+LE   E  R    +++IR YSKQI   +  LH + I+HRDIK ANI +     IKL DFG S  L      +   V +T+GT  + APEVI T   G  +  +ADIWS+G  VI M+TG+ P++ Y H F ++ ++    K  +PE   +S   K F+   L  DP  R TA+QLL   F
Sbjct: 1312 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE---EVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1596          
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K4 (mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6856])

HSP 1 Score: 157.147 bits (396), Expect = 2.778e-39
Identity = 102/291 (35.05%), Postives = 150/291 (51.55%), Query Frame = 2
Query:  788 SMMGLECKPPFCNHRLCKTSLKNKTF--AKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAV-TTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +++G  C  P     +    L+  TF   +G++IG G +G +Y C       + A+K I       K I+E  +       + H  ++RYFG    ++ + IFMEY  +G+LE   E  R    +++IR YSKQI   +  LH + I+HRDIK ANI +     IKL DFG S  L      +   V +T+GT  + APEVI T   G  +  +ADIWS+G  VI M+TG+ P++ Y H F ++ ++    K  +PE   +S   K F+   L  DP  R TA+QLL   F
Sbjct: 1262 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE---EVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1546          
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K4 (mitogen-activated protein kinase kinase kinase 4 [Source:HGNC Symbol;Acc:HGNC:6856])

HSP 1 Score: 157.147 bits (396), Expect = 2.823e-39
Identity = 102/291 (35.05%), Postives = 150/291 (51.55%), Query Frame = 2
Query:  788 SMMGLECKPPFCNHRLCKTSLKNKTF--AKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAV-TTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +++G  C  P     +    L+  TF   +G++IG G +G +Y C       + A+K I       K I+E  +       + H  ++RYFG    ++ + IFMEY  +G+LE   E  R    +++IR YSKQI   +  LH + I+HRDIK ANI +     IKL DFG S  L      +   V +T+GT  + APEVI T   G  +  +ADIWS+G  VI M+TG+ P++ Y H F ++ ++    K  +PE   +S   K F+   L  DP  R TA+QLL   F
Sbjct: 1316 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE---EVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1600          
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:HGNC Symbol;Acc:HGNC:6854])

HSP 1 Score: 152.91 bits (385), Expect = 1.035e-38
Identity = 95/257 (36.96%), Postives = 140/257 (54.47%), Query Frame = 2
Query:  872 GSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRIS---TSKKLELPESELMSDAMKG-FIEEMLNPDPDQ 1603
            G  +G G FG +Y C         A+K ++    S +  +E +N        L  L+H+RI++Y+G ++      L IFMEY+  GS++D++ K     T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   ADIWS+  TV+ M+T +PP+      A I +I+   T+ KL    S+   D +K  F+E  L P  D+
Sbjct:  359 GKLLGQGAFGRVYLCYDVDTGRELAVKQVQFDPDSPETSKE-VNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQL-KAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI----SGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSADE 609          
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 150.599 bits (379), Expect = 2.565e-38
Identity = 97/262 (37.02%), Postives = 141/262 (53.82%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKY--IEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            F K   IG G FG +YK   +    V AIK I+L +  ++   I++ I   L +   + + +YFG+      L I MEYL  GS  D + K   +   +I    ++IL+GLE+LH  R IHRDIK AN+L+    ++K+ADFG++  L  T   + K +T +G+P + APE+I  S     Y   ADIWS+G T I +  G PP+   HP  V+  I  +    L  S+  S   K F+E  LN DP+ R +A+ LLK +F 
Sbjct:   14 FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQ-VLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTET---VKKRITFVGSPFWMAPELIKQSS----YDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQ-WSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 265          
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 150.599 bits (379), Expect = 2.627e-38
Identity = 97/262 (37.02%), Postives = 141/262 (53.82%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKY--IEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            F K   IG G FG +YK   +    V AIK I+L +  ++   I++ I   L +   + + +YFG+      L I MEYL  GS  D + K   +   +I    ++IL+GLE+LH  R IHRDIK AN+L+    ++K+ADFG++  L  T   + K +T +G+P + APE+I  S     Y   ADIWS+G T I +  G PP+   HP  V+  I  +    L  S+  S   K F+E  LN DP+ R +A+ LLK +F 
Sbjct:   19 FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQ-VLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTET---VKKRITFVGSPFWMAPELIKQSS----YDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQ-WSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 270          
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 150.599 bits (379), Expect = 3.080e-38
Identity = 97/262 (37.02%), Postives = 141/262 (53.82%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKY--IEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            F K   IG G FG +YK   +    V AIK I+L +  ++   I++ I   L +   + + +YFG+      L I MEYL  GS  D + K   +   +I    ++IL+GLE+LH  R IHRDIK AN+L+    ++K+ADFG++  L  T   + K +T +G+P + APE+I  S     Y   ADIWS+G T I +  G PP+   HP  V+  I  +    L  S+  S   K F+E  LN DP+ R +A+ LLK +F 
Sbjct:   34 FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQ-VLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTET---VKKRITFVGSPFWMAPELIKQSS----YDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQ-WSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 285          
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: gck-1 (Germinal center kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:H2L099])

HSP 1 Score: 150.599 bits (379), Expect = 6.775e-38
Identity = 97/262 (37.02%), Postives = 141/262 (53.82%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKY--IEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            F K   IG G FG +YK   +    V AIK I+L +  ++   I++ I   L +   + + +YFG+      L I MEYL  GS  D + K   +   +I    ++IL+GLE+LH  R IHRDIK AN+L+    ++K+ADFG++  L  T   + K +T +G+P + APE+I  S     Y   ADIWS+G T I +  G PP+   HP  V+  I  +    L  S+  S   K F+E  LN DP+ R +A+ LLK +F 
Sbjct:  184 FTKQERIGRGSFGEVYKGIDNRTGRVVAIKIIDLEQAEDEIEDIQQEIQ-VLSQCDSQYVTKYFGSFLKGSKLWIIMEYLGGGSALD-LTKSGKLDESHIAVILREILKGLEYLHSERKIHRDIKAANVLVSEHGDVKVADFGVAGQLTET---VKKRITFVGSPFWMAPELIKQSS----YDYKADIWSLGITAIELANGEPPHSDLHPMRVLFLIPKNPPPVLQGSQ-WSKPFKEFVEMCLNKDPENRPSASTLLKHQFI 435          
BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Match: pak-1 (Serine/threonine-protein kinase pak-1 [Source:UniProtKB/Swiss-Prot;Acc:Q17850])

HSP 1 Score: 140.969 bits (354), Expect = 1.582e-35
Identity = 87/263 (33.08%), Postives = 131/263 (49.81%), Query Frame = 2
Query:  854 NKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            ++ + K  +IGSG  G +Y       +   AIK + L    +K +  N    + +  H  I+ Y  +    D L + MEYL  GSL D + + + +    I    +++L+ LEFLH   +IHRDIK  NIL+G + ++KL DFG    L     E  K  T +GTP + APEV+     GP      D+WS+G   I M+ G PPY   +P   I  I+T+ K + P  + M+   K F++  L    + R +A+QLL   F 
Sbjct:  243 DRKYRKVDKIGSGASGSVYTAIEISTEAEVAIKQMNLKDQPKKELIINEILVMRENKHANIVNYLDSYLVCDELWVVMEYLAGGSLTDVVTECQ-MEDGIIAAVCREVLQALEFLHSRHVIHRDIKSDNILLGMDGSVKLTDFGFCAQL---SPEQRKRTTMVGTPYWMAPEVVTRKQYGP----KVDVWSLGIMAIEMVEGEPPYLNENPLRAIYLIATNGKPDFPGRDSMTLLFKDFVDSALEVQVENRWSASQLLTHPFL 497          
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334539)

HSP 1 Score: 150.214 bits (378), Expect = 8.969e-38
Identity = 87/263 (33.08%), Postives = 138/263 (52.47%), Query Frame = 2
Query:  854 NKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            N+ + K  +IG G  G +Y    S      AIK + L +  +K +  N    + +  H  ++ Y  +    + L + MEYL  GSL D +  +  +    I    +++L+ LEFLH N++IHRDIK  NIL+G + ++KL DFG    +     E +K  T +GTP + APEV+     GP      D+WS+G   I M+ G PPY   +P   +  I+T+ K E+ E + +S A + F+++ L  + D+R++A  LLK  F 
Sbjct:  427 NRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV-TETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQI---SPEQSKRTTMVGTPYWMAPEVVTRKQYGP----KVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL 681          
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081714)

HSP 1 Score: 150.214 bits (378), Expect = 8.969e-38
Identity = 87/263 (33.08%), Postives = 138/263 (52.47%), Query Frame = 2
Query:  854 NKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            N+ + K  +IG G  G +Y    S      AIK + L +  +K +  N    + +  H  ++ Y  +    + L + MEYL  GSL D +  +  +    I    +++L+ LEFLH N++IHRDIK  NIL+G + ++KL DFG    +     E +K  T +GTP + APEV+     GP      D+WS+G   I M+ G PPY   +P   +  I+T+ K E+ E + +S A + F+++ L  + D+R++A  LLK  F 
Sbjct:  427 NRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV-TETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQI---SPEQSKRTTMVGTPYWMAPEVVTRKQYGP----KVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL 681          
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081716)

HSP 1 Score: 150.214 bits (378), Expect = 8.969e-38
Identity = 87/263 (33.08%), Postives = 138/263 (52.47%), Query Frame = 2
Query:  854 NKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            N+ + K  +IG G  G +Y    S      AIK + L +  +K +  N    + +  H  ++ Y  +    + L + MEYL  GSL D +  +  +    I    +++L+ LEFLH N++IHRDIK  NIL+G + ++KL DFG    +     E +K  T +GTP + APEV+     GP      D+WS+G   I M+ G PPY   +P   +  I+T+ K E+ E + +S A + F+++ L  + D+R++A  LLK  F 
Sbjct:  427 NRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV-TETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQI---SPEQSKRTTMVGTPYWMAPEVVTRKQYGP----KVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL 681          
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0081715)

HSP 1 Score: 150.214 bits (378), Expect = 8.969e-38
Identity = 87/263 (33.08%), Postives = 138/263 (52.47%), Query Frame = 2
Query:  854 NKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            N+ + K  +IG G  G +Y    S      AIK + L +  +K +  N    + +  H  ++ Y  +    + L + MEYL  GSL D +  +  +    I    +++L+ LEFLH N++IHRDIK  NIL+G + ++KL DFG    +     E +K  T +GTP + APEV+     GP      D+WS+G   I M+ G PPY   +P   +  I+T+ K E+ E + +S A + F+++ L  + D+R++A  LLK  F 
Sbjct:  427 NRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV-TETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQI---SPEQSKRTTMVGTPYWMAPEVVTRKQYGP----KVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL 681          
BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Match: Pak (gene:FBgn0267698 transcript:FBtr0334544)

HSP 1 Score: 150.214 bits (378), Expect = 8.969e-38
Identity = 87/263 (33.08%), Postives = 138/263 (52.47%), Query Frame = 2
Query:  854 NKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            N+ + K  +IG G  G +Y    S      AIK + L +  +K +  N    + +  H  ++ Y  +    + L + MEYL  GSL D +  +  +    I    +++L+ LEFLH N++IHRDIK  NIL+G + ++KL DFG    +     E +K  T +GTP + APEV+     GP      D+WS+G   I M+ G PPY   +P   +  I+T+ K E+ E + +S A + F+++ L  + D+R++A  LLK  F 
Sbjct:  427 NRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVNYLDSYLVSEELWVVMEYLPGGSLTDVV-TETCMDEGQIAAVCREVLQALEFLHANQVIHRDIKSDNILLGLDGSVKLTDFGFCAQI---SPEQSKRTTMVGTPYWMAPEVVTRKQYGP----KVDLWSLGIMAIEMVEGEPPYLNENPLKALYLIATNGKPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKHPFL 681          
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 155.606 bits (392), Expect = 8.265e-40
Identity = 99/274 (36.13%), Postives = 145/274 (52.92%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-----TFLPKLMHKRIIRYFGAIQTKDH----LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPE--SELMSDAMKG-FIEEMLNPDPDQRSTAAQLLKLKF 1639
            T+ +G  +G G FG +Y C         A K +     S +  +E          L  L H+RI++Y+G +  +DH    L IFMEY+  GS++D++ K     T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     +LP   SE   D ++  F+E    P      +A +LL+  F
Sbjct:  343 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHHERIVQYYGCL--RDHNEKTLTIFMEYMPGGSVKDQL-KAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI----SGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPSHISEHTRDFLRCIFVEAKYRP------SAEELLRHPF 603          
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 155.606 bits (392), Expect = 9.702e-40
Identity = 99/274 (36.13%), Postives = 145/274 (52.92%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-----TFLPKLMHKRIIRYFGAIQTKDH----LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPE--SELMSDAMKG-FIEEMLNPDPDQRSTAAQLLKLKF 1639
            T+ +G  +G G FG +Y C         A K +     S +  +E          L  L H+RI++Y+G +  +DH    L IFMEY+  GS++D++ K     T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     +LP   SE   D ++  F+E    P      +A +LL+  F
Sbjct:  355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHHERIVQYYGCL--RDHNEKTLTIFMEYMPGGSVKDQL-KAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI----SGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPSHISEHTRDFLRCIFVEAKYRP------SAEELLRHPF 615          
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 155.221 bits (391), Expect = 1.089e-39
Identity = 99/274 (36.13%), Postives = 145/274 (52.92%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-----TFLPKLMHKRIIRYFGAIQTKDH----LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPE--SELMSDAMKG-FIEEMLNPDPDQRSTAAQLLKLKF 1639
            T+ +G  +G G FG +Y C         A K +     S +  +E          L  L H+RI++Y+G +  +DH    L IFMEY+  GS++D++ K     T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     +LP   SE   D ++  F+E    P      +A +LL+  F
Sbjct:  361 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHHERIVQYYGCL--RDHNEKTLTIFMEYMPGGSVKDQL-KAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI----SGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPSHISEHTRDFLRCIFVEAKYRP------SAEELLRHPF 621          
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k19 (mitogen-activated protein kinase kinase kinase 19 [Source:ZFIN;Acc:ZDB-GENE-081104-140])

HSP 1 Score: 148.288 bits (373), Expect = 1.115e-39
Identity = 95/276 (34.42%), Postives = 151/276 (54.71%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIEL----IKISEK---YIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSL--MRTC----GEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSE 1648
            T+ KG  +G G +G +Y C  +    + A+K + L     +I+EK    +E  ++  L  L H  I+ + G   +++ + IFMEY+  GS+ + + +   +  K  + YS+QILEG+ +LH NR+IHRD+K  NI++ P   +KL DFG +R L  ++T     G++ K+V   GTP + APEVI  + +G      +DIWS+G TV  M TG+PP  + +  A +  I   + L    S+  S   K F++  L  D  QR +A +LL+  F S 
Sbjct:   20 TWTKGEVLGKGAYGTVY-CGLTSQGQLIAVKQVALDASTSEIAEKEYDRLEREVD-LLKNLKHTNIVGFLGTALSENIVSIFMEYIPGGSISNILGQFGPLPEKVFVLYSQQILEGVAYLHANRVIHRDLKGNNIMLMPTGVVKLIDFGCARRLSCLQTSTGSKGDLLKSVH--GTPYWMAPEVINETGHG----RKSDIWSIGCTVFEMATGKPPLAHMNKMAALYYIGARRGLMPSLSDDFSTDAKDFVQACLTRDQRQRPSAEELLRHPFISH 287          
BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Match: map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:ZFIN;Acc:ZDB-GENE-990603-4])

HSP 1 Score: 155.606 bits (392), Expect = 5.762e-39
Identity = 101/294 (34.35%), Postives = 152/294 (51.70%), Query Frame = 2
Query:  779 QQISMMGLECKPPFCNHRLCKTSLKNKTF--AKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAV-TTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +Q +++G  C  P     +    L+  TF   +G++IG G +G +Y C       + A+K I       K I+E  +       + H  ++RYFG    ++ + IFMEY  +G+LE   E  R    +++IR YSKQI   +  LH + I+HRDIK ANI +     IKL DFG S  L      +   V +T+GT  + APEVI T   G  +  +ADIWS+G  +I M+TG+ P++ Y H F ++ R+    K  +PE   +S   K F+   L  +P +R TA+ LL   F
Sbjct: 1245 RQRNIIGQVCNTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCINVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE---EVSRLGLQEHVIRLYSKQITTAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-TRAKGEGHGRAADIWSLGCVLIEMVTGKRPWHEYEHNFQIMYRVGMGHKPPIPEK--LSTEGKDFLAHCLESEPKRRWTASALLDHPF 1532          
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 157.532 bits (397), Expect = 2.555e-40
Identity = 93/267 (34.83%), Postives = 144/267 (53.93%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-----TFLPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            + +G  +G G FG +Y C         A K ++    S +  +E          L  L H RI++Y+G+++ K    L IFMEY+  GS++D+++    +      RY++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     +LP +   S+  + F++ +L  +  QR TA +L++  F
Sbjct:  365 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI----SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPPN--TSEQCRDFVKRIL-VEARQRPTAEELIRHPF 624          
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 157.147 bits (396), Expect = 3.455e-40
Identity = 93/267 (34.83%), Postives = 144/267 (53.93%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-----TFLPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            + +G  +G G FG +Y C         A K ++    S +  +E          L  L H RI++Y+G+++ K    L IFMEY+  GS++D+++    +      RY++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     +LP +   S+  + F++ +L  +  QR TA +L++  F
Sbjct:  347 WRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI----SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPPN--TSEQCRDFVKRIL-VEARQRPTAEELIRHPF 606          
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 155.992 bits (393), Expect = 1.009e-39
Identity = 95/267 (35.58%), Postives = 151/267 (56.55%), Query Frame = 2
Query:  872 GSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF-----LPKL-MHKRIIRYFGAIQ--TKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFS 1645
            G  +G G FG +Y C         A+K +     S++  +E +N       L KL  H+RI++Y+G ++  T+  L IF+EY+  GS++D+++    +      RY++QIL+G+ +LHGN I+HRDIK ANIL     N+KL DFG S+ +   C   T   +  GTP + +PEVI    +G  Y   AD+WS+  TV+ M+T +PP+      A I +I+T   K  LP++  +SDA + F++++   +  +R TA +LL+  F S
Sbjct:  357 GKLLGRGAFGEVYLCYDVDKGRELAVKQVPFDPDSQETSKE-VNALECEIQLLKLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVI----SGEGYGRKADVWSVACTVVEMLTEKPPWSEYEAMAAIFKIATQPTKPRLPDT--VSDACRDFMKQIFV-EEKRRPTAEELLRHLFVS 615          
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 155.606 bits (392), Expect = 1.212e-39
Identity = 95/267 (35.58%), Postives = 151/267 (56.55%), Query Frame = 2
Query:  872 GSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF-----LPKL-MHKRIIRYFGAIQ--TKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFS 1645
            G  +G G FG +Y C         A+K +     S++  +E +N       L KL  H+RI++Y+G ++  T+  L IF+EY+  GS++D+++    +      RY++QIL+G+ +LHGN I+HRDIK ANIL     N+KL DFG S+ +   C   T   +  GTP + +PEVI    +G  Y   AD+WS+  TV+ M+T +PP+      A I +I+T   K  LP++  +SDA + F++++   +  +R TA +LL+  F S
Sbjct:  364 GKLLGRGAFGEVYLCYDVDKGRELAVKQVPFDPDSQETSKE-VNALECEIQLLKLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVI----SGEGYGRKADVWSVACTVVEMLTEKPPWSEYEAMAAIFKIATQPTKPRLPDT--VSDACRDFMKQIFV-EEKRRPTAEELLRHLFVS 622          
BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 152.525 bits (384), Expect = 1.063e-38
Identity = 95/264 (35.98%), Postives = 143/264 (54.17%), Query Frame = 2
Query:  872 GSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPE--SELMSDAMKG-FIEEMLNPDPDQ--RSTAAQ 1621
            G  +G G FG +Y C  +      A+K ++    S +  +E +N        L  L+H+RI++Y+G ++      L IFMEY+  GS++D+++    +      +Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   ADIWS+G TV+ M+T +PP+      A I +I+T     +LP   SE   D +K  F+E  + P  ++  R T AQ
Sbjct:  342 GKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPDSLETSKE-VNALECEIQLLKNLLHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI----SGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLPAHVSEHCRDFLKRIFVEAKVRPSSEELLRHTFAQ 600          
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:MGI Symbol;Acc:MGI:1346875])

HSP 1 Score: 155.992 bits (393), Expect = 4.456e-39
Identity = 101/291 (34.71%), Postives = 150/291 (51.55%), Query Frame = 2
Query:  788 SMMGLECKPPFCNHRLCKTSLKNKTF--AKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAV-TTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +++G  C  P     +    L+  TF   +G++IG G +G +Y C       + A+K I       K I+E  +       + H  ++RYFG    ++ + IFMEY  +G+LE   E  R    +++IR Y+KQI   +  LH + I+HRDIK ANI +     IKL DFG S  L      +   V +T+GT  + APEVI T   G  +  +ADIWS+G  VI M+TG+ P++ Y H F ++ ++    K  +PE   +S   K F+   L  DP  R TA+QLL   F
Sbjct: 1253 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE---EVSRLGLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSPEGKAFLSHCLESDPKIRWTASQLLDHAF 1537          
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k4 (mitogen-activated protein kinase kinase kinase 4 [Source:MGI Symbol;Acc:MGI:1346875])

HSP 1 Score: 155.992 bits (393), Expect = 4.955e-39
Identity = 101/291 (34.71%), Postives = 150/291 (51.55%), Query Frame = 2
Query:  788 SMMGLECKPPFCNHRLCKTSLKNKTF--AKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAV-TTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +++G  C  P     +    L+  TF   +G++IG G +G +Y C       + A+K I       K I+E  +       + H  ++RYFG    ++ + IFMEY  +G+LE   E  R    +++IR Y+KQI   +  LH + I+HRDIK ANI +     IKL DFG S  L      +   V +T+GT  + APEVI T   G  +  +ADIWS+G  VI M+TG+ P++ Y H F ++ ++    K  +PE   +S   K F+   L  DP  R TA+QLL   F
Sbjct: 1305 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE---EVSRLGLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSPEGKAFLSHCLESDPKIRWTASQLLDHAF 1589          
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873])

HSP 1 Score: 152.14 bits (383), Expect = 1.314e-38
Identity = 99/269 (36.80%), Postives = 145/269 (53.90%), Query Frame = 2
Query:  872 GSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRIS---TSKKLELPESELMSDAMKG-FIEEMLNPDPDQRSTAAQLLKLKF 1639
            G  +G G FG +Y C         A+K ++    S +  +E +N        L  L+H+RI++Y+G ++      L IFMEY+  GS++D++ K     T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     NIKL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   ADIWS+  TV+ M+T +PP+      A I +I+   T+ KL    S+   D +K  F+E  L P      +A +LL+  F
Sbjct:  359 GKLLGQGAFGRVYLCYDVDTGRELAVKQVQFNPESPETSKE-VNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQL-KAYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI----SGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRP------SAEELLRHMF 615          
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874])

HSP 1 Score: 151.369 bits (381), Expect = 2.926e-38
Identity = 90/267 (33.71%), Postives = 141/267 (52.81%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-----TFLPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            + +G  +G G FG +Y C         A K ++    S +  +E          L  L H+RI++Y+G ++ +    L IFMEY+  GS++D+++    +      +Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     +LP    +S+  + F+  +   +  QR +A +LL   F
Sbjct:  362 WRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI----SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSH--ISEHGRDFLRRIF-VEARQRPSAEELLTHHF 621          
BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Match: Stk25 (serine/threonine kinase 25 (yeast) [Source:MGI Symbol;Acc:MGI:1891699])

HSP 1 Score: 145.591 bits (366), Expect = 1.743e-37
Identity = 104/268 (38.81%), Postives = 140/268 (52.24%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-TFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIE----KKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEF 1651
            F K   IG G FG +YK   +    V AIK I+L +  ++  +     T L +     I RYFG+      L I MEYL  GS  D ++    ++ +IAT  I+R   +IL+GL++LH  R IHRDIK AN+L+  + ++KLADFG++  L  T     K  T +GTP + APEVI  S     Y   ADIWS+G T I +  G PP    HP  V+  I  +    L      S   K F+E  LN DP  R TA +LLK KF + +
Sbjct:   20 FTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIAT--ILR---EILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQ---IKRNTFVGTPFWMAPEVIKQS----AYDFKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPTLEGHH--SKPFKEFVEACLNKDPRFRPTAKELLKHKFITRY 273          
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q54PX0|Y4251_DICDI (Probable serine/threonine-protein kinase DDB_G0284251 OS=Dictyostelium discoideum OX=44689 GN=DDB_G0284251 PE=3 SV=1)

HSP 1 Score: 160.229 bits (404), Expect = 2.774e-41
Identity = 95/270 (35.19%), Postives = 145/270 (53.70%), Query Frame = 2
Query:  839 KTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIE--ENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            K+ +K   +  G +IG G FG ++K          AIK I+  KI E  ++  +     L KL H  I++  G ++ +  L   +EY+  GSL D IEK   ++ +  I Y  Q+L+GL +LH N++IHRDIK +NIL+  E  IKLADFG++  +     E     + +GTP + APE I  S      + ++DIWS+G+T+I ++TG PPYY   P A + RI + +    P    +S     + ++    DP QR TA +LL+   F
Sbjct:   28 KSIVKIGEYTLGEKIGRGAFGQVFKGLNGKTGEFVAIKQIDSNKIDESSLQSVKGEVEILHKLRHNNIVKVLGVVEVQAQLNFILEYVENGSLRDVIEKFGPLSEELCIIYLYQMLQGLAYLHSNKVIHRDIKASNILITKEGVIKLADFGVASQI---DSESQLRFSVVGTPYWMAPESIEISG----CSSASDIWSLGSTMIELLTGNPPYYTLQPMAAMFRIVSDQHPPFPTD--ISKEFLDYFQQSFKKDPTQRPTAQELLQHPIF 288          
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|F4HRJ4|M3K3A_ARATH (Mitogen-activated protein kinase kinase kinase 3 OS=Arabidopsis thaliana OX=3702 GN=MAPKKK3 PE=1 SV=1)

HSP 1 Score: 157.147 bits (396), Expect = 1.676e-39
Identity = 96/268 (35.82%), Postives = 151/268 (56.34%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISE------KYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKL-ELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            T+ KG  +GSG FG +Y    S    + AIK +++I   +      K + + IN  L +L H  I++Y+G+  +++ L +++EY+  GS+   ++         I  Y++QIL GL +LHG   +HRDIK ANIL+ P   IKLADFG+++ +       +  ++  G+P + APEV++ S NG  YT + DIWS+G T++ M T +PP+      A I +I  SK   E+P+   +S+  K FI   L  +P  R TA+QLL+  F 
Sbjct:  213 TWKKGKFLGSGTFGQVYLGFNSEKGKMCAIKEVKVISDDQTSKECLKQLNQEIN-LLNQLCHPNIVQYYGSELSEETLSVYLEYVSGGSIHKLLKDYGSFTEPVIQNYTRQILAGLAYLHGRNTVHRDIKGANILVDPNGEIKLADFGMAKHVT----AFSTMLSFKGSPYWMAPEVVM-SQNG--YTHAVDIWSLGCTILEMATSKPPWSQFEGVAAIFKIGNSKDTPEIPDH--LSNDAKNFIRLCLQRNPTVRPTASQLLEHPFL 470          
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|O22042|M3K3_ARATH (Mitogen-activated protein kinase kinase kinase 3 OS=Arabidopsis thaliana OX=3702 GN=ANP3 PE=1 SV=1)

HSP 1 Score: 155.606 bits (392), Expect = 9.851e-39
Identity = 107/296 (36.15%), Postives = 154/296 (52.03%), Query Frame = 2
Query:  788 SMMGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISE---------KYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFS 1645
            S +GL  KPP       K    +  + KG  IG G FG +Y         + AIK + +   S          + +EE +   L  L H  I+RY G ++  D L I ME++  GS+   +EK        II Y+KQ+L GLE+LH N I+HRDIK ANIL+  +  I+LADFG S+ ++     +  A +  GTP + APEVIL +     ++ SADIWS+G TVI M TG+PP+      FA +  I  +K    P  E +S   K F+ + L+ +P  R +A +LL+  F +
Sbjct:   43 SRIGLFSKPPPGLPAPRKEEAPSIRWRKGELIGCGAFGRVYMGMNLDSGELLAIKQVLIAPSSASKEKTQGHIRELEEEVQ-LLKNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYTKQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVE-LATVNGAKSMKGTPYWMAPEVILQTG----HSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKA-HPPIPEDLSPEAKDFLMKCLHKEPSLRLSATELLQHPFVT 331          
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9Y6R4|M3K4_HUMAN (Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens OX=9606 GN=MAP3K4 PE=1 SV=2)

HSP 1 Score: 157.147 bits (396), Expect = 1.356e-38
Identity = 102/291 (35.05%), Postives = 150/291 (51.55%), Query Frame = 2
Query:  788 SMMGLECKPPFCNHRLCKTSLKNKTF--AKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAV-TTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +++G  C  P     +    L+  TF   +G++IG G +G +Y C       + A+K I       K I+E  +       + H  ++RYFG    ++ + IFMEY  +G+LE   E  R    +++IR YSKQI   +  LH + I+HRDIK ANI +     IKL DFG S  L      +   V +T+GT  + APEVI T   G  +  +ADIWS+G  VI M+TG+ P++ Y H F ++ ++    K  +PE   +S   K F+   L  DP  R TA+QLL   F
Sbjct: 1316 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE---EVSRLGLQEHVIRLYSKQITIAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSPEGKDFLSHCLESDPKMRWTASQLLDHSF 1600          
BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Match: sp|O08648|M3K4_MOUSE (Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus OX=10090 GN=Map3k4 PE=1 SV=2)

HSP 1 Score: 155.992 bits (393), Expect = 3.466e-38
Identity = 101/291 (34.71%), Postives = 150/291 (51.55%), Query Frame = 2
Query:  788 SMMGLECKPPFCNHRLCKTSLKNKTF--AKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAV-TTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYY-YCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +++G  C  P     +    L+  TF   +G++IG G +G +Y C       + A+K I       K I+E  +       + H  ++RYFG    ++ + IFMEY  +G+LE   E  R    +++IR Y+KQI   +  LH + I+HRDIK ANI +     IKL DFG S  L      +   V +T+GT  + APEVI T   G  +  +ADIWS+G  VI M+TG+ P++ Y H F ++ ++    K  +PE   +S   K F+   L  DP  R TA+QLL   F
Sbjct: 1305 NIIGQVCDTPKSYDNVMHVGLRKVTFKWQRGNKIGEGQYGKVYTCISVDTGELMAMKEIRFQPNDHKTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLE---EVSRLGLQEHVIRLYTKQITVAINVLHEHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNNAQTMPGEVNSTLGTAAYMAPEVI-TRAKGEGHGRAADIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGHKPPIPER--LSPEGKAFLSHCLESDPKIRWTASQLLDHAF 1589          
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0H3YJG2 (Slc42a-1 OS=Schmidtea mediterranea OX=79327 GN=slc42a-1 PE=2 SV=1)

HSP 1 Score: 230.72 bits (587), Expect = 2.428e-61
Identity = 150/445 (33.71%), Postives = 230/445 (51.69%), Query Frame = 2
Query:  302 WGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAIXXXXXXXXXXXXXXXXXQQISM-MGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATK--NIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLL 1627
            +   PI +AC  G  + V   I   C++ + D      +  AV   N +I+ +LI                    +G+ I   D ++                PIH AC+  NI+  + L++  CD+   DK    PL IA   + + +++++KE ++ ++I+  M L+C    CNH+ C TS + K       I SG +G ++    SG D  FA+K I    I  +YIE NIN F   L H+RI+++FGA   K++  IFMEYL      D ++KK++      +++ ++KQILE L FLH   IIHRDIKP N+L+  + N+KL+DFG+S  L     +I K     GT  + APE++    N   YT S DIWS+GAT+I + TG+PPY+     A+I  IST++++E    E M   +   I+ ML  D  +R +A +LL
Sbjct:  538 YSRSPILYACKYGHRKIVKYFIKQKCNVDSFDCEFRRALHYAVISNNNDIVKLLIE-------------------SGAAINVPDSLL--------------MMPIHLACKVNNIEAAQLLMENNCDMVTLDKLKRSPLQIAETGDFENMIKLIKECQIIREIAAEMQLKC-GKLCNHKFCYTSFQRKKIKNRKCIASGSYGTVFLYNESGTDRKFAVKKIPKQNIRARYIEANINDFKNLLCHERIVKHFGAFHKKENHYIFMEYL------DTLQKKKYQKKSPGDLLLFAKQILEALSFLHERSIIHRDIKPENVLLDIDGNLKLSDFGLSLLLSSVAEDIQKEGRCCGTYCYAAPEIL----NAELYTCSVDIWSLGATMIQLCTGQPPYHNLGDGAIITVISTTREIEYKLPEYMPKYISNLIDHMLEKDQYKRLSAKKLL 938          

HSP 2 Score: 81.2629 bits (199), Expect = 4.945e-12
Identity = 47/123 (38.21%), Postives = 69/123 (56.10%), Query Frame = 2
Query:  116 PIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLL 484
            PI YAC   H +IVK  I   C++++ D   RR +HYA  +++ + VKLLI     I   D     PIH AC + +IE   LL++ +CD+  LDK   SP++IA   G+ E +  LI  C ++
Sbjct:  542 PILYACKYGHRKIVKYFIKQKCNVDSFDCEFRRALHYAVISNNNDIVKLLIESGAAINVPDSLLMMPIHLACKVNNIEAAQLLMENNCDMVTLDKLKRSPLQIA-ETGDFENMIKLIKECQII 663          

HSP 3 Score: 74.3294 bits (181), Expect = 6.386e-10
Identity = 38/108 (35.19%), Postives = 61/108 (56.48%), Query Frame = 2
Query:    5 WKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHA 328
            + R PI YAC+  + ++VK  I   CN+++ D    R +HYA ++ + +IVKLLI+    I   D     PIH AC  ++ EA +LL+ ++CD+   D+    P+  A
Sbjct:  538 YSRSPILYACKYGHRKIVKYFIKQKCNVDSFDCEFRRALHYAVISNNNDIVKLLIESGAAINVPDSLLMMPIHLACKVNNIEAAQLLMENNCDMVTLDKLKRSPLQIA 645          
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A2C9JTY9 (Protein kinase domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106068194 PE=4 SV=1)

HSP 1 Score: 181.8 bits (460), Expect = 1.613e-47
Identity = 107/272 (39.34%), Postives = 158/272 (58.09%), Query Frame = 2
Query:  857 KTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISE---KYIEENIN--TFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMR-TCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESEL---MSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFS 1645
            K +  G  +GSGG+G +Y C  S    +FA+K ++L  ++    K ++  IN    L K+ H+RI++Y G  + K+ L IF+EY+  GSL + +++   +        +KQILEGL FLH N I+HRDIK ANIL     NIKL DFG+SR L   +C   +   TTIG+P + APEVI  +     Y ++AD+WS+G TV+ M+T +PP+ +  P A I +I T K    PE EL   MSD +K F+      +  +R +A++LL   F +
Sbjct:   61 KQYTIGRLLGSGGYGRVYLCCDSSTSILFAMKQVDLGNLNSHISKEVQALINEVQILSKIQHERIVQYLGCQENKESLSIFLEYMPGGSLLNHMQQFGPLTEAVAGNCTKQILEGLVFLHKNNIVHRDIKAANILRDTVGNIKLTDFGVSRQLHSISCA--SGLNTTIGSPYWMAPEVIKEAG----YGQNADLWSVGCTVVEMLTTKPPFSHLEPCAAIYKIVTCK---YPEYELPAGMSDLVKNFLNTAFQLNSSKRKSASELLHHSFIT 323          
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A210PFZ5 (Mitogen-activated protein kinase kinase kinase 2 OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT24565 PE=4 SV=1)

HSP 1 Score: 179.104 bits (453), Expect = 1.676e-46
Identity = 100/274 (36.50%), Postives = 150/274 (54.74%), Query Frame = 2
Query:  833 LCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKIS-----EKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
              K+      + KG  +GSG FG ++ C         A+K + L +++     E    EN    L    H+RI+ YFG  Q    L IFMEY+  GS++DE+ K   +      +Y++Q+LEGL FLH N I+HRDIK AN+L   + NIKLADFG S+ L   C   T   + +GTP++ APEVI    NG  Y   AD+WS+G TV+ MI+G+PP+      A I +I+T+++ E    +  S+  + F+      +P +R ++  LL+ +F
Sbjct:  120 FSKSPRAPSNWKKGHRLGSGSFGEVFVCYDKDSGRELAVKQVNLNQMNAETSKEVRALENEIQLLRNFQHERIVSYFGCHQDHSILSIFMEYMPGGSIKDELAKYGPLTEGVTRKYTRQMLEGLAFLHKNVIVHRDIKAANVLRDLQGNIKLADFGASKRLHTIC-SATGFKSFVGTPHYMAPEVI----NGEGYGRKADVWSLGCTVVEMISGKPPWSELESMAAIYKIATAERPEFELPQRSSEFSREFLRLTFRRNPLERPSSEDLLRHRF 388          
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: C3Z0I8 (Uncharacterized protein (Fragment) OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_221293 PE=4 SV=1)

HSP 1 Score: 180.644 bits (457), Expect = 3.143e-45
Identity = 105/267 (39.33%), Postives = 157/267 (58.80%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIEL----IKISE--KYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKL-ELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            + +G  +G G FG +Y C  +      A+K + L    ++ S+  K +E  I   L  L H+RI++Y+G IQ ++ LCIFMEY+  GS++D+I +   + T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ +   C   T   T  GTP + +PEVI    NG  Y   ADIWS+G TV+ M+T +PP++   P A I +I+T   + +LP    +SD    F+  +   D  QR++A +LL+  F
Sbjct:  347 WRQGKLLGQGAFGQVYLCYDADTGRELALKQVHLDPKNVEASKEVKALECEIQ-LLKNLQHERIVQYYGCIQDENRLCIFMEYMPGGSVKDQIRQYGAL-TENVTRKYTRQILEGILYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICS-ATGMRTVTGTPYWMSPEVI----NGEGYGRKADIWSIGCTVVEMLTEKPPWFDYEPMAAIFKIATQPTIPKLPAG--VSDCAHDFLRIIFQKDHRQRASAQELLEHSF 604          
BLAST of Protein kinase domain-containing protein vs. TrEMBL
Match: A0A0R3RIB6 (Protein kinase domain-containing protein OS=Elaeophora elaphi OX=1147741 PE=4 SV=1)

HSP 1 Score: 175.252 bits (443), Expect = 3.400e-44
Identity = 101/271 (37.27%), Postives = 155/271 (57.20%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN------TFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRIST-SKKLELPESELMSDA-MKGFIEEMLNPDPDQRSTAAQLLKLKFFSEF 1651
            + +G  IGSG FG +Y C         A+K   + + ++K++  +I         L  + H RI++Y GA Q +D +CIF+EY+  GS++D I     +++    +Y+ Q+L+GLE+LH N IIHRDIKPANIL     N+K+ DFG ++ L   C +  +A T IGTPN+ APEV+L       +   ADIWS+G T++ M+T +PP+    P A+I  I+  +   ELP   L +D  +  FI  +   + D+R +A+QLL    F +F
Sbjct:  219 WKQGKCIGSGAFGKVYVCVDVDTGKEVALKRFNICR-ADKHLTNHIIQLGNEINLLSTIQHARIVQYLGAQQIEDSICIFIEYMTGGSVKDYIATYGPLSSTVAGKYTYQVLQGLEYLHRNEIIHRDIKPANILRDSNGNVKIGDFGSAKRLQTICSQ--QAATFIGTPNYMAPEVVLGHTT---HGRKADIWSVGCTLVEMLTTKPPWDDLEPMAIIFNIAKHNPSYELP---LGADPDLAHFINVVFERNVDKRPSASQLLNNFAFHKF 480          
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 157.918 bits (398), Expect = 1.013e-40
Identity = 97/271 (35.79%), Postives = 147/271 (54.24%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH----LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            T+ +G  +G G FG +Y C         A K ++    S +  +E ++T       L  L H+RI++Y+G +  +DH    L IFMEY+  GS++D++ K     T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     +  S   S+  + FI  +   +   R +A +LL+  F
Sbjct:  355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKE-VSTLECEIQLLKNLHHERIVQYYGCL--RDHNEKTLTIFMEYMPGGSVKDQL-KAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI----SGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILPSH-TSEQTRDFIRRIF-VEAKHRPSAEELLRHPF 615          
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 157.918 bits (398), Expect = 1.013e-40
Identity = 97/271 (35.79%), Postives = 147/271 (54.24%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH----LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            T+ +G  +G G FG +Y C         A K ++    S +  +E ++T       L  L H+RI++Y+G +  +DH    L IFMEY+  GS++D++ K     T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     +  S   S+  + FI  +   +   R +A +LL+  F
Sbjct:  355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKE-VSTLECEIQLLKNLHHERIVQYYGCL--RDHNEKTLTIFMEYMPGGSVKDQL-KAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI----SGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILPSH-TSEQTRDFIRRIF-VEAKHRPSAEELLRHPF 615          
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 157.918 bits (398), Expect = 1.013e-40
Identity = 97/271 (35.79%), Postives = 147/271 (54.24%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH----LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            T+ +G  +G G FG +Y C         A K ++    S +  +E ++T       L  L H+RI++Y+G +  +DH    L IFMEY+  GS++D++ K     T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     +  S   S+  + FI  +   +   R +A +LL+  F
Sbjct:  355 TWRRGKLLGQGAFGRVYLCYDVDTGRELAAKQVQFDPASPETSKE-VSTLECEIQLLKNLHHERIVQYYGCL--RDHNEKTLTIFMEYMPGGSVKDQL-KAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI----SGDGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPILPSH-TSEQTRDFIRRIF-VEAKHRPSAEELLRHPF 615          
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3-like [Source:NCBI gene;Acc:103044968])

HSP 1 Score: 154.451 bits (389), Expect = 1.676e-39
Identity = 93/269 (34.57%), Postives = 144/269 (53.53%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
             + +G  +G G FG +Y C  +      A+K +       +  +E +N        L  L H+RI++Y+G ++  +   L IF+E++  GS++D+++    +  K   RY++QIL+G+ +LH N I+HRDIK ANIL     N+KL DFG S+ +   C   T   T  GTP + +PEVI    NG  Y   AD+WS+  TV+ M+T +PP+      A I +I+T   K  LPE   +SDA + F+ ++   +   R TA  LL   F
Sbjct:  356 NWRQGKLLGRGAFGEVYLCYDADTGRELAVKQVPFDPECHETSKE-VNALECEIQLLKNLRHERIVQYYGCLRDPEQRKLSIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVFYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKTVTGTPYWMSPEVI----NGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQPTKPNLPEG--VSDACRDFLRQVF-VEEKWRPTAEGLLSHPF 616          
BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3-like [Source:NCBI gene;Acc:103044968])

HSP 1 Score: 154.451 bits (389), Expect = 2.005e-39
Identity = 93/269 (34.57%), Postives = 144/269 (53.53%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
             + +G  +G G FG +Y C  +      A+K +       +  +E +N        L  L H+RI++Y+G ++  +   L IF+E++  GS++D+++    +  K   RY++QIL+G+ +LH N I+HRDIK ANIL     N+KL DFG S+ +   C   T   T  GTP + +PEVI    NG  Y   AD+WS+  TV+ M+T +PP+      A I +I+T   K  LPE   +SDA + F+ ++   +   R TA  LL   F
Sbjct:  353 NWRQGKLLGRGAFGEVYLCYDADTGRELAVKQVPFDPECHETSKE-VNALECEIQLLKNLRHERIVQYYGCLRDPEQRKLSIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVFYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKTVTGTPYWMSPEVI----NGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQPTKPNLPEG--VSDACRDFLRQVF-VEEKWRPTAEGLLSHPF 613          
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 166.777 bits (421), Expect = 1.767e-44
Identity = 102/272 (37.50%), Postives = 149/272 (54.78%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS---KKLELPESELMSDAMKG-FIEEMLNPDPDQRSTAAQLLKLKF 1639
            + +G  +G G FG +Y C  +      A+K ++    S +  +E +N        L  L H+RI++YFG ++      L IFMEY+  GS++D++     + T+N+ R Y++QILEG+ FLHGN I+HRDIK ANIL     N+KL DFG S+ L   C + T   +  GTP + +PEVI    NG  Y   ADIWS+G TV+ M+T +PP+      A I +I+T     +L L  SE   D ++  F+E  L P      +A  LL+  F
Sbjct:  359 WQRGKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPGSVETSKE-VNALECEIQLLKNLQHERIVQYFGCLRDPQQKTLSIFMEYMPGGSIKDQLRAYGAL-TENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGTAMRSVTGTPYWMSPEVI----NGEGYGRKADIWSVGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTDPRLPLHASEHARDLLRRIFVEAKLRP------SAEDLLRHPF 618          
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: stk25a (serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-GENE-041010-92])

HSP 1 Score: 137.887 bits (346), Expect = 1.586e-35
Identity = 99/262 (37.79%), Postives = 133/262 (50.76%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-TFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIK--PANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            F K   IG G FG ++K   +    V AIK I+L +  ++  +     T L +     +  YFG+      L I MEYL  GS  D I K   +    I    ++IL+GL++LH  R IHRDIK   AN+L+  + ++KLADFG++  L  T     K  T +GTP + APEVI  S     Y   ADIWS+G T I +  G PP    HP  V+  I  +    L  +   S A K F++  LN DP  R TA +LLK KF
Sbjct:   26 FTKQERIGKGSFGEVFKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTHYFGSYLKGTKLWIIMEYLGGGSALDLI-KPGPLEEHQIATILREILKGLDYLHSERKIHRDIKGPAANVLLSEQGDVKLADFGVAGQLTDTQ---IKRNTFVGTPFWMAPEVIKQS----AYDFKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPTLEGN--YSKAFKEFVDSCLNKDPQFRPTAKELLKHKF 277          
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: slka (STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-050411-66])

HSP 1 Score: 135.576 bits (340), Expect = 2.930e-33
Identity = 90/263 (34.22%), Postives = 139/263 (52.85%), Query Frame = 2
Query:  878 EIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF--LPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLED-EIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSD-NGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEFD 1654
            E+G G FG +YK +      + A K IE    SE+ +E+ +     L    H  I+    A   ++ L IF+E+   G+++   +E +R +A   I    KQ+LE L +LH +RIIHRD+K  NIL+  E ++KLADFG+S    RT   + +  + IGTP + APEV++       PY   ADIWS+G T+I +    PP +  +P  V+ +I+ +    L      S     F+++ L+ +P+ R  A QLL+  F S  D
Sbjct:   38 ELGDGAFGKVYKAQNKESGVLAAAKVIETK--SEEELEDYMVEIEILALCDHPNIVGLLNAFYYENKLWIFIEFCPGGAVDAIMLELERGLAEPQIRVVCKQMLEALNYLHTHRIIHRDLKAGNILLTFEGDVKLADFGVSAKNTRT---LQRRDSFIGTPYWMAPEVVMCETMKDAPYDYKADIWSLGITLIELAQMEPPNHELNPMRVMLKIAKNDPPSLSFPSKWSAEFTDFLKKCLDKNPETRWNALQLLQHSFISGVD 295          
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6865])

HSP 1 Score: 132.109 bits (331), Expect = 2.340e-32
Identity = 80/267 (29.96%), Postives = 133/267 (49.81%), Query Frame = 2
Query:  854 NKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS--KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSE 1648
             + F     +GSG +G ++K +      + AIK I+L    +  + +     + +  H  I+ Y+G+    D L I ME+   GSL+D       +  + I   +++ L+GL +LH    +HRDIK ANIL+  + ++KLADFG+S  +  T   I K  + IGTP + APEV      G  Y    D+W++G T I +   +PP +  HP   +  +S S  +  +L + +  S     FI+  L  +P +R TA ++L   +  +
Sbjct:   11 QEDFELAERLGSGTYGDVHKARNVQTGELVAIKIIKLEPGDDFSVIQQEIVMMKECKHTNIVAYYGSYLRHDKLWICMEHCGGGSLQDIYHVTGPLTERQIAYVTRETLQGLAYLHSEGKMHRDIKGANILLTDDGDVKLADFGVSAQITAT---IAKRKSFIGTPYWMAPEVAAVERKG-GYNHQCDVWAVGITAIELAELQPPMFDLHPMRALFLMSKSGFQPPKLRDKQKWSPVFHNFIKMALTKNPKKRPTAEKMLTHSYVQQ 273          
BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Match: pak4 (p21 protein (Cdc42/Rac)-activated kinase 4 [Source:ZFIN;Acc:ZDB-GENE-040704-69])

HSP 1 Score: 128.642 bits (322), Expect = 2.009e-31
Identity = 80/259 (30.89%), Postives = 128/259 (49.42%), Query Frame = 2
Query:  878 EIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTT----IGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            +IG G  G +            A+K + L K   + +  N    + +  H+ ++  + +    D L + ME+L  G+L D +   R +  + I      +L  L +LHG  +IHRDIK  +IL+  +  IKL+DFG        C +++K VT     +GTP + APEVI       PY    D+WS+G  VI M+ G PPY+   P   + RI  +   ++   +  S  ++GF+++ML  DP  R+TA +LL+  F 
Sbjct:  424 KIGEGSTGVVCLAVDRRSGRQVAVKKMHLRKQQRRELLFNEVVIMREYHHENVVDMYNSYLVADELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCVSVLRALAYLHGQGVIHRDIKSDSILLTADGRIKLSDFGF-------CAQVSKEVTRRKSLVGTPYWMAPEVISRL----PYGPEVDVWSLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNVPPKMKNIQKASPLLRGFLDQMLVRDPALRATALELLQHPFL 670          
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: STE20 (Cdc42p-activated signal transducing kinase; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p; member of the PAK (p21-activated kinase) family [Source:SGD;Acc:S000000999])

HSP 1 Score: 138.658 bits (348), Expect = 1.280e-34
Identity = 90/279 (32.26%), Postives = 138/279 (49.46%), Query Frame = 2
Query:  827 HRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEIT----KAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEF 1651
            + +C     +  +A   +IG G  G +Y     G +   AIK + L K  +K +  N    +    H  I+ +  +   K  L + MEY+  GSL D +     +    I    ++ L GLEFLH   ++HRDIK  NIL+  E +IKL DFG        C +I     K  T +GTP + APEV+   + GP      DIWS+G  +I MI G PPY    P   +  I+T+   +L E E +S ++K F++  L  +P+ R++A +LL  ++ +E 
Sbjct:  608 NEICSDGDPSTKYANLVKIGQGASGGVYTAYEIGTNVSVAIKQMNLEKQPKKELIINEILVMKGSKHPNIVNFIDSYVLKGDLWVIMEYMEGGSLTDVV-THCILTEGQIGAVCRETLSGLEFLHSKGVLHRDIKSDNILLSMEGDIKLTDFGF-------CAQINELNLKRTTMVGTPYWMAPEVVSRKEYGP----KVDIWSLGIMIIEMIEGEPPYLNETPLRALYLIATNGTPKLKEPENLSSSLKKFLDWCLCVEPEDRASATELLHDEYITEI 874          
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 130.183 bits (326), Expect = 8.853e-32
Identity = 88/253 (34.78%), Postives = 135/253 (53.36%), Query Frame = 2
Query:  881 IGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN--TFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLK 1630
            IG G +G +YK      D V AIK  E++  +++ + + +   + L  L H  I++Y G I+    L I +EY   GSL   I +     ++N  + Y  Q L GL++LHG  +IHRDIK ANIL+  +N +KLADFG+S  +       + A+T  GT N+ APE++   + G   +  +DIWS+GATV+ M+T  PPY+      +   +        P S   S+ +K F+ +    +  +R TA QLLK
Sbjct:   31 IGRGSYGVVYKAINKHTDQVVAIK--EVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVN------SSALTLAGTLNWMAPEIL--GNRGA--STLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTY--YPPSSF-SEPLKDFLSKCFVKNMYKRPTADQLLK 268          
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: SSK22 (MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway; functionally redundant with Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p; SSK22 has a paralog, SSK2, that arose from the whole genome duplication [Source:SGD;Acc:S000000669])

HSP 1 Score: 129.413 bits (324), Expect = 1.565e-31
Identity = 90/274 (32.85%), Postives = 142/274 (51.82%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIEL-----IKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLM----RTC--------GEITKAVT-TIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYC-HPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLL 1627
            + K S IG G FG +Y         + A+K I++     +K     I+E + T L  L H  I++Y+G    +D + IFMEY   GSL   ++  R         Y+ ++LEGL +LH + ++HRDIKP NIL+     IK  DFG +R+++    RT         G  TK++   +GTP + APE I  S        + D+W++G  V+ M TGR P+    + +A++  ++  +  +LP  + M+ A + F+E  L  DP  R+TA +LL
Sbjct: 1034 WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTTTMKKIFPLIKEEM-TVLEMLNHPNIVQYYGVEVHRDKVNIFMEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIKPENILLDFNGIIKYVDFGTARTVVGSRTRTVRNAAVQDFGVETKSLNEMMGTPMYMAPETISGSAVKGKLG-ADDVWALGCVVLEMATGRRPWSNLDNEWAIMYHVAAGRIPQLPNRDEMTAAGRAFLERCLVQDPTMRATAVELL 1305          
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931])

HSP 1 Score: 124.79 bits (312), Expect = 7.826e-31
Identity = 90/272 (33.09%), Postives = 130/272 (47.79%), Query Frame = 2
Query:  854 NKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINT------FLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRF--IATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSK--KLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            +K ++  S IG G FG +YK        + AIK + L     ++ +E+I        FL +L    I  Y   +     + I MEY   GS  D +++     +  + +     ++  GL++LH  R IHRDIK ANIL+  E  +KL DFG+S  +  T     K  T +GTP + APEV+    +G  Y E ADIWS+G T   ++ G PP     P  V+  +   K  KL+ P     SDA K F+   L   P  R +A  LL  +F
Sbjct:   15 SKLYSIQSCIGRGNFGDVYKAVDRVTQEIVAIKVVNL-----EHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLHEQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTL----KRDTFVGTPYWMAPEVVCCEVDG--YNEKADIWSLGITTYELLKGLPPLSKYDPMKVMTNLPKRKPPKLQGP----FSDAAKDFVAGCLVKTPADRPSAYNLLSFEF 271          
BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 126.716 bits (317), Expect = 9.474e-31
Identity = 93/263 (35.36%), Postives = 131/263 (49.81%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKY--IEENINTFLPKLMH-KRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFF 1642
            F +   IG G FG +YK        V+AIK + L   S++   ++  I  FL  L     I RY+G+      L I ME+   GSL   +   + I  K I    +++L  L+ +H + +IHRDIK AN+L+  E N+KL DFG++  + +T     +  T  GTP + APEVI+    G  Y    DIWS+G T   + TG PPY        +  I  SK   L E    S ++K FI   L+ DP +R +A  LLK KF 
Sbjct:   23 FKRTEVIGRGKFGVVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQ-FLASLKQISNITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGK-IDEKYIGVIMRELLVALKCIHKDNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTS---LRRQTMAGTPYWMAPEVIM---EGVYYDTKVDIWSLGITTYEIATGNPPYCDVEALRAMQLIIKSKPPRL-EDRSYSTSLKEFIALCLDEDPKERLSADDLLKSKFI 276          
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7])

HSP 1 Score: 168.703 bits (426), Expect = 7.198e-48
Identity = 105/269 (39.03%), Postives = 156/269 (57.99%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISE------KYIEENINTFLPKLMHKRIIRYFGAIQTKD-HLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFS 1645
            + KG  +G+G FG +Y C         A+K IE  +++       K +E  I  F+    ++RI++Y+G I+T D H+ IFMEYL  GS+ + I++   +      +YS+QILEG+ +LH NRI+HRDIK ANIL     N+KLADFG S+ L +T    T   +  GTP + APEVI    NG  Y   AD+WS+G TV+ M+T +PP+    P A + +I+T   + ELP S+L  DA++ F+   L  +   R +A +LL+  F +
Sbjct:    4 WRKGKLLGAGAFGQVYMCHDLDTGRELAVKQIETGQLNSSTKNEVKALEGEIE-FMKAFRNERIVQYYG-IETDDLHIYIFMEYLPGGSIHEHIKQHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRL-QTIRSKTGFRSVHGTPYWMAPEVI----NGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALFKIATQPTEPELP-SDLSVDAVE-FVRSTLRMNSKSRPSADELLRFSFVT 263          
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO31934 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SWI4])

HSP 1 Score: 143.28 bits (360), Expect = 2.251e-37
Identity = 99/266 (37.22%), Postives = 143/266 (53.76%), Query Frame = 2
Query:  857 KTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-TFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIE----KKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            K F+K   IG G FG ++K   +  + V AIK I+L +  ++  +     T L +     + +Y G+      L I MEYL  GS  D ++    ++ +IAT  I+R   ++L+GL++LH  + +HRDIK AN+LM    ++KLADFG++  L  T   + K  T +GTP + APEVI  S     Y   ADIWS+G T I +  G PP    HP  V+  I  +   EL  +   S A K F+   LN DP+ R TA +LLK +F
Sbjct:    9 KLFSKLERIGKGSFGEVFKGIDNRTNEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSLYVTKYHGSYLKGTKLWIIMEYLGGGSALDLMKAGNIEEFYIAT--ILR---EVLKGLDYLHTEKKLHRDIKAANVLMSETGDVKLADFGVAGQLTDT---LNKRNTFVGTPFWMAPEVIKQS----AYDSKADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNNPPELTGN--FSKAFKEFVSLCLNKDPNDRPTAKELLKHRF 260          
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO33667 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRJ0])

HSP 1 Score: 141.354 bits (355), Expect = 5.218e-36
Identity = 87/264 (32.95%), Postives = 131/264 (49.62%), Query Frame = 2
Query:  857 KTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSE 1648
            K + K  +IG G  G +Y           AIK + L +  +K +  N    + +  H  I+ Y  +    + L + MEYL  GSL D +  +  +    I    ++ L+ LEFLH N +IHRDIK  NIL+G +  +KL DFG   ++     E  K  T +GTP + APEV+     GP      D+WS+G   I M+ G PPY   +P   +  I+T+   EL   E +S   K F+ + L  D ++RS+A +LL+  F  +
Sbjct:  224 KKYTKFEKIGQGASGTVYTAIEVATGHEVAIKQMNLSQQPKKELIINEILVMRENKHPNIVNYVDSYLVGEELWVVMEYLAGGSLTDVV-TETCMDEGQIAAVCRECLQALEFLHSNGVIHRDIKSDNILLGMDGQVKLTDFGFCATI---TPEQNKRSTMVGTPYWMAPEVVTRKQYGP----RVDVWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELAHPEKLSPVFKDFLAQSLEMDVEKRSSARELLQHPFLKQ 479          
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO47821 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RL88])

HSP 1 Score: 134.42 bits (337), Expect = 1.678e-35
Identity = 90/276 (32.61%), Postives = 141/276 (51.09%), Query Frame = 2
Query:  863 FAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIEL----IKISEKY---IEENINTFLPKLMHKRIIRYFGAIQTKDHLC---IFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKA---VTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKL-ELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSE 1648
            + KG+ +G G FG ++         + A+K +EL    +  +E+    ++E +   L  L HK I++Y G     D  C   IFME++  GS+   +++          RY++QIL+G+ +LH N +IHRDIK  NI++ P   IKL DFG ++ +      ++K+    +  GTP + APEVI  + +G      +DIWS+G TV  M TG+PP+    P + I  I     +  L ES   S A   F+   +  D D R +A +LL+  F  E
Sbjct:    5 WQKGNVLGKGAFGTVF-LGLVNTGELIAVKQVELHPNNVDAAERQYEKLQEEVG-LLKSLKHKNIVQYIGTCM-DDSQCTINIFMEFVPGGSIAQALKRFGAFVEPVFRRYTRQILDGVSYLHNNNVIHRDIKGGNIMLMPNGVIKLIDFGCAKKICMVGAHVSKSNILRSMRGTPYWMAPEVIRETGHG----RKSDIWSIGCTVFEMATGQPPWSNVPPLSAIFAIGNGSPVPRLDES--FSAAAIDFVTSCMTRDQDTRPSADELLRHDFLQE 271          
BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9])

HSP 1 Score: 135.576 bits (340), Expect = 2.554e-35
Identity = 89/257 (34.63%), Postives = 135/257 (52.53%), Query Frame = 2
Query:  878 EIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFS 1645
            ++G G +G ++K        V AIK + +    ++ I+E   + + +     +++Y+G+      L I MEY   GS+ D ++ +    T+  I+   K  L+GLE+LH  R IHRDIK  NIL+  E + KLADFG++  L  T   + K  T IGTP + APEVI   + G  Y   ADIWS+G T + M  G+PPY   HP   I  I T       +    S+  K F+ + L  +P++R+TA +LL+  F  
Sbjct:   29 KLGEGSYGSVFKAMHKESGQVVAIKQVPVDTDLQEIIKEI--SMMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDLMKIRNKTLTEEEIKCVLKYTLKGLEYLHLRRKIHRDIKAGNILLNSEGHAKLADFGVAGQLTDT---MAKRNTVIGTPFWMAPEVI--QEVG--YDCLADIWSLGITAMEMAEGKPPYADIHPMRAIFMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSFIQ 276          
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 155.221 bits (391), Expect = 8.013e-40
Identity = 93/274 (33.94%), Postives = 141/274 (51.46%), Query Frame = 2
Query:  821 CNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKG-----FIEEMLNPDPD 1600
            C     K+      + +G  +G G FG +Y C  +      A K +      ++  +E +N        L  L H RI++Y+G ++  D   L IF+E++  GS++D+++    +  K   RY++QIL+G+ +LH N I+HRDIK ANIL     N+KL DFG S+ +   C   T   +  GTP + +PEVI    NG  Y   AD+WS+  TV+ M+T +PP+      A I +I+T   K  LPE   +SDA +      F+EE   P  D
Sbjct:  313 CQRGTAKSPRAPVNWRQGKLLGRGAFGEVYLCYDADTGRELAAKQVPFDPDCQETSKE-VNALECEIQLLKNLRHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVI----NGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQPTKPTLPEG--VSDASRDFLRQVFVEEKWRPTAD 579          
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290])

HSP 1 Score: 155.221 bits (391), Expect = 1.085e-39
Identity = 98/270 (36.30%), Postives = 144/270 (53.33%), Query Frame = 2
Query:  860 TFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-----TFLPKLMHKRIIRYFGAIQTKDH----LCIFMEYLFKGSLEDEIEKKRFIATKNIIR-YSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            T+ +G  +G G FG +Y C         A K ++    S +  +E          L  L H+RI++Y+G +  +DH    L IFMEY+  GS++D++ K     T+N+ R Y++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG S+ L   C   T   +  GTP + +PEVI    +G  Y   AD+WS+G TV+ M+T +PP+      A I +I+T     L  S   SD  + FI  +   +   R +A +LL+  F
Sbjct:  352 TWRRGKLLGQGAFGLVYLCYDVDTGRELAAKQVQFDPDSPETSKEVSALECEIQLLKNLHHERIVQYYGCL--RDHSEKTLTIFMEYMPGGSVKDQL-KAYGALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI----SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPLLPSH-TSDQARDFIHCIF-VEAKHRPSAEELLRHPF 612          
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 155.221 bits (391), Expect = 1.118e-39
Identity = 93/274 (33.94%), Postives = 141/274 (51.46%), Query Frame = 2
Query:  821 CNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKG-----FIEEMLNPDPD 1600
            C     K+      + +G  +G G FG +Y C  +      A K +      ++  +E +N        L  L H RI++Y+G ++  D   L IF+E++  GS++D+++    +  K   RY++QIL+G+ +LH N I+HRDIK ANIL     N+KL DFG S+ +   C   T   +  GTP + +PEVI    NG  Y   AD+WS+  TV+ M+T +PP+      A I +I+T   K  LPE   +SDA +      F+EE   P  D
Sbjct:  343 CQRGTAKSPRAPVNWRQGKLLGRGAFGEVYLCYDADTGRELAAKQVPFDPDCQETSKE-VNALECEIQLLKNLRHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVI----NGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQPTKPTLPEG--VSDASRDFLRQVFVEEKWRPTAD 609          
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 155.221 bits (391), Expect = 1.118e-39
Identity = 93/274 (33.94%), Postives = 141/274 (51.46%), Query Frame = 2
Query:  821 CNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTF------LPKLMHKRIIRYFGAIQTKDH--LCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKG-----FIEEMLNPDPD 1600
            C     K+      + +G  +G G FG +Y C  +      A K +      ++  +E +N        L  L H RI++Y+G ++  D   L IF+E++  GS++D+++    +  K   RY++QIL+G+ +LH N I+HRDIK ANIL     N+KL DFG S+ +   C   T   +  GTP + +PEVI    NG  Y   AD+WS+  TV+ M+T +PP+      A I +I+T   K  LPE   +SDA +      F+EE   P  D
Sbjct:  343 CQRGTAKSPRAPVNWRQGKLLGRGAFGEVYLCYDADTGRELAAKQVPFDPDCQETSKE-VNALECEIQLLKNLRHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKSVTGTPYWMSPEVI----NGEGYGRKADVWSVACTVVEMLTQKPPWAEYEAMAAIFKIATQPTKPTLPEG--VSDASRDFLRQVFVEEKWRPTAD 609          
BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297])

HSP 1 Score: 153.68 bits (387), Expect = 4.002e-39
Identity = 95/264 (35.98%), Postives = 142/264 (53.79%), Query Frame = 2
Query:  872 GSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENIN-----TFLPKLMHKRIIRYFGAIQT--KDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTS-KKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKF 1639
            G  +G G FG +Y C  +      A+K ++    S +  +E          L  L H+RI++Y+G ++   +  L IFME++  GS++D+++    +      RY++QILEG+ +LH N I+HRDIK ANIL     N+KL DFG SR L   C   T   +  GTP + +PEVI    +G  Y   ADIWS+G TV+ M+T RPP+      A I +I+T     ELP    +SD  + F+  +   +  QR +A +LL+  F
Sbjct:  392 GKLLGQGAFGRVYLCYDADTGRELAVKQVQFDPESPETSKEVSALECEIQLLKNLCHERIVQYYGCLRDTMERTLSIFMEHMPGGSIKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSGTGIKSVTGTPYWMSPEVI----SGEGYGRKADIWSVGCTVVEMLTQRPPWAEFEAMAAIFKIATQPTNPELPVH--VSDHCREFLRRIFV-ETKQRPSADELLRHIF 648          
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000032703.1 (SMESG000032703.1)

HSP 1 Score: 897.501 bits (2318), Expect = 0.000e+0
Identity = 469/553 (84.81%), Postives = 492/553 (88.97%), Query Frame = 2
Query:    2 QWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAIXXXXXXXXXXXXXXXXXQQISMMGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEFDFD 1660
            Q   RPIH+A RE + E VKLLID+HC+++A D+   RPIH  C + HIE+ KLLID+HCDIEA D    RPIH+AC + H E VKLLI HHCDI+A D   W+PIHHAC  G+IET+ LLID++C+I ALDK G+SPIEIAVR  NE IIH+L G  LLLAC  GD +KVS+ LN  TIEYCDK              GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAIKKENKELVEILKEEELEQQISMMGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEFDFD
Sbjct:  377 QNDYRPIHFALREGHTEAVKLLIDYHCDVDAPDKWNIRPIHLTCRSGHIEVSKLLIDHHCDIEAPDELGFRPIHHACRSGHIETVKLLIDHHCDIDASDRNDWQPIHHACVAGNIETLKLLIDHYCNIEALDKFGDSPIEIAVRSCNEGIIHLLNGARLLLACKTGDTKKVSRLLNSITIEYCDK--------------GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAIKKENKELVEILKEEELEQQISMMGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEFDFD 915          

HSP 2 Score: 207.994 bits (528), Expect = 4.513e-57
Identity = 118/235 (50.21%), Postives = 150/235 (63.83%), Query Frame = 2
Query:   14 RPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIG-PCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPL 715
            RPIHYAC   ++++VKLLID+HC+I+ASD + WRPIH AC A HIEIVKLLIDYHCDI A D    RPIH+A  A H E +KLLI HHCDIE FD    RPIH AC  G IET+ LLI +HCDI ALD++   PI  A+R G+ E + +LI   C + A    ++  +        IE    +I+     E  +  G  RPIH AC SG+I+ VK LI   CDI A D+++ +P+
Sbjct:  249 RPIHYACCAGHMKIVKLLIDYHCDIDASDTNDWRPIHLACGAGHIEIVKLLIDYHCDINASDMNDNRPIHFALRAGHIETMKLLIDHHCDIEVFDRHKQRPIHLACIAGHIETMKLLIYHHCDIDALDQNDYRPIHFALREGHTEAVKLLIDYHCDVDAPDKWNIRPIHLTCRSGHIEVSKLLIDHHCDIEAPDELG-FRPIHHACRSGHIETVKLLIDHHCDIDASDRNDWQPI 482          

HSP 3 Score: 201.445 bits (511), Expect = 9.127e-55
Identity = 117/243 (48.15%), Postives = 151/243 (62.14%), Query Frame = 2
Query:    2 QWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIG-PCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAI 727
            ++ +RPIH+AC   +IE V +LI  + NIE  D   WR IH+AC A HIE +KLLID+HCDIEA D   +R IH ACSA H EAVKLLI HHCDIEA D+  WRPIH+AC  G ++ V LLIDYHCDI A D +   PI +A   G+ EI+ +LI   C + A    D   +   L    IE    +I+     E V    K+RPIH AC +G+I+ +K LI   CDI A D+++ RP+  A+
Sbjct:  146 KYDQRPIHFACIAGHIETVNILIKEYYNIEILDGFDWRLIHHACSAGHIETMKLLIDHHCDIEAFDWRNKRSIHLACSAGHIEAVKLLIYHHCDIEALDQNDWRPIHYACCAGHMKIVKLLIDYHCDIDASDTNDWRPIHLACGAGHIEIVKLLIDYHCDINASDMNDNRPIHFALRAGHIETMKLLIDHHCDIE-VFDRHKQRPIHLACIAGHIETMKLLIYHHCDIDALDQNDYRPIHFAL 387          

HSP 4 Score: 197.978 bits (502), Expect = 1.249e-53
Identity = 120/250 (48.00%), Postives = 148/250 (59.20%), Query Frame = 2
Query:   14 RPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIG-PC------------LLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIA 724
            R IH+AC   +IE +KLLIDHHC+IEA D    R IH AC A HIE VKLLI +HCDIEALD+   RPIHYAC A H + VKLLI +HCDI+A D   WRPIH AC  G IE V LLIDYHCDI A D + N PI  A+R G+ E + +LI   C            + LAC  G +E +   +      +CD  I+ L   +        RPIH+A   G+ + VK LI   CD+ A DK N+RP+ + 
Sbjct:  183 RLIHHACSAGHIETMKLLIDHHCDIEAFDWRNKRSIHLACSAGHIEAVKLLIYHHCDIEALDQNDWRPIHYACCAGHMKIVKLLIDYHCDIDASDTNDWRPIHLACGAGHIEIVKLLIDYHCDINASDMNDNRPIHFALRAGHIETMKLLIDHHCDIEVFDRHKQRPIHLACIAGHIETMKLLI----YHHCD--IDALDQND-------YRPIHFALREGHTEAVKLLIDYHCDVDAPDKWNIRPIHLT 419          

HSP 5 Score: 196.438 bits (498), Expect = 4.349e-53
Identity = 119/266 (44.74%), Postives = 152/266 (57.14%), Query Frame = 2
Query:   14 RPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDI----------------EALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLL-------------ACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIA 724
            RPIH+AC E  IE+VKLLID+HCNIEASD S WRPIH+AC A + E VKLLI+ H  I                + LDR  R+PIH+ C+A H E VKLLI HHCDIE+ D  G RPIHHAC  G +E V LLID+HC+I AL K    PI  A   G+ E +++LI     +             AC+ G +E +   ++     +CD  IE    R        +R IH AC +G+I+ VK LI   CDI A D+++ RP+  A
Sbjct:    2 RPIHHACSENQIEIVKLLIDYHCNIEASDESNWRPIHHACSAGNTEAVKLLINCHPSIWVLDGSEWPIIQRVCEKPLDRSNRQPIHHTCNARHVETVKLLIDHHCDIESLDNSGGRPIHHACIGGCMEVVKLLIDHHCNIDALGKYDQRPIHFACIAGHIETVNILIKEYYNIEILDGFDWRLIHHACSAGHIETMKLLID----HHCD--IEAFDWR-------NKRSIHLACSAGHIEAVKLLIYHHCDIEALDQNDWRPIHYA 254          

HSP 6 Score: 194.126 bits (492), Expect = 3.109e-52
Identity = 109/238 (45.80%), Postives = 147/238 (61.76%), Query Frame = 2
Query:   11 RRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIA 724
            R+PIH+ C   ++E VKLLIDHHC+IE+ D SG RPIH+AC+   +E+VKLLID+HC+I+AL ++ +RPIH+AC A H E V +LI  + +IE  D + WR IHHAC  G IET+ LLID+HCDI A D            + N+  IH        LAC+ G +E V   +      +CD  IE L   +        RPIH+AC +G++KIVK LI   CDI A D ++ RP+ +A
Sbjct:   83 RQPIHHTCNARHVETVKLLIDHHCDIESLDNSGGRPIHHACIGGCMEVVKLLIDHHCNIDALGKYDQRPIHFACIAGHIETVNILIKEYYNIEILDGFDWRLIHHACSAGHIETMKLLIDHHCDIEAFD------------WRNKRSIH--------LACSAGHIEAVKLLI----YHHCD--IEALDQND-------WRPIHYACCAGHMKIVKLLIDYHCDIDASDTNDWRPIHLA 287          
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000017196.1 (SMESG000017196.1)

HSP 1 Score: 825.854 bits (2132), Expect = 0.000e+0
Identity = 422/566 (74.56%), Postives = 467/566 (82.51%), Query Frame = 2
Query:    2 QWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAIXXXXXXXXXXXXXXXXXQQ----------------ISMMGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEF 1651
            +WKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKV              +RRPIHWACESGNI++VK LIK+KC IT KDK +L PLDIA + +NKELV+++K+  L Q+                I  MGL+C   FC+HRLC TSL+N +F KGS+IG G  G IYKCKGSG D VFA+K   L  IS+KY+E NI  FLPKL H+RII+YFGAI   D LCIFMEY  +G+LEDEI++K F+  +NIIRYSKQILEGLEFLHGN IIHRDIKP+NI+M  +N+IKLADFGISRSL+RT G  T+  T  GT NF APEVIL SD+G PYTESADIWSMGATVINMITG+PPYY     A+I +I+++KKLELP S+LMS+ MK FIEEMLNPDPD+RSTA  LL LK FSEF
Sbjct:  214 EWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKV--------------QRRPIHWACESGNIELVKLLIKSKCKITIKDKSDLSPLDIARRNDNKELVQVIKDAILVQEPERELELERQEQVEKLIVAMGLKC-TAFCDHRLCPTSLRNLSFEKGSKIGIGSCGMIYKCKGSGTDKVFAVKRTVLYDISQKYVEGNIYKFLPKLNHQRIIKYFGAILMDDRLCIFMEYFSEGTLEDEIKRKIFLTRENIIRYSKQILEGLEFLHGNSIIHRDIKPSNIMMTSDNDIKLADFGISRSLLRTNGLATRPATIAGTLNFIAPEVILASDDGAPYTESADIWSMGATVINMITGKPPYYNSITPALIFKIASTKKLELPNSQLMSEEMKEFIEEMLNPDPDKRSTAKNLLTLKLFSEF 764          

HSP 2 Score: 200.675 bits (509), Expect = 4.287e-55
Identity = 118/238 (49.58%), Postives = 143/238 (60.08%), Query Frame = 2
Query:   14 RPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNS-PIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIA 724
            RPIH+AC   +I++VKLLIDH+C+IEA D  G RPIH+AC   H EIVKLLID+ CDIEALD    RPIH+AC   H E VKLLI H+CDIEA DE GWRPIHHA + G    V LLID HCDI + D   N  PI  A   G+ EI+ +LI         + D+E     + G  I +  K  EW           KRRPIH+AC    I++VK LI   C+I A D+   RP+  A
Sbjct:   38 RPIHHACSAGHIDIVKLLIDHNCDIEAIDALGLRPIHHACRIGHTEIVKLLIDHFCDIEALDALGLRPIHHACRIGHTEIVKLLIDHYCDIEACDESGWRPIHHATNKGQTGIVKLLIDCHCDIESRDNWWNRMPIHHACSVGHIEIVKLLID-------HHCDVEARDN-VGGQFIMHAKKSDEW-----------KRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYA 256          
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000017196.1 (SMESG000017196.1)

HSP 1 Score: 824.313 bits (2128), Expect = 0.000e+0
Identity = 422/566 (74.56%), Postives = 467/566 (82.51%), Query Frame = 2
Query:    2 QWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAIXXXXXXXXXXXXXXXXXQQ----------------ISMMGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEF 1651
            +WKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKV              +RRPIHWACESGNI++VK LIK+KC IT KDK +L PLDIA + +NKELV+++K+  L Q+                I  MGL+C   FC+HRLC TSL+N +F KGS+IG G  G IYKCKGSG D VFA+K   L  IS+KY+E NI  FLPKL H+RII+YFGAI   D LCIFMEY  +G+LEDEI++K F+  +NIIRYSKQILEGLEFLHGN IIHRDIKP+NI+M  +N+IKLADFGISRSL+RT G  T+  T  GT NF APEVIL SD+G PYTESADIWSMGATVINMITG+PPYY     A+I +I+++KKLELP S+LMS+ MK FIEEMLNPDPD+RSTA  LL LK FSEF
Sbjct:  233 EWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKV--------------QRRPIHWACESGNIELVKLLIKSKCKITIKDKSDLSPLDIARRNDNKELVQVIKDAILVQEPERELELERQEQVEKLIVAMGLKCTA-FCDHRLCPTSLRNLSFEKGSKIGIGSCGMIYKCKGSGTDKVFAVKRTVLYDISQKYVEGNIYKFLPKLNHQRIIKYFGAILMDDRLCIFMEYFSEGTLEDEIKRKIFLTRENIIRYSKQILEGLEFLHGNSIIHRDIKPSNIMMTSDNDIKLADFGISRSLLRTNGLATRPATIAGTLNFIAPEVILASDDGAPYTESADIWSMGATVINMITGKPPYYNSITPALIFKIASTKKLELPNSQLMSEEMKEFIEEMLNPDPDKRSTAKNLLTLKLFSEF 783          

HSP 2 Score: 194.897 bits (494), Expect = 5.556e-53
Identity = 117/239 (48.95%), Postives = 143/239 (59.83%), Query Frame = 2
Query:   14 RPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNS-PIEIAVRYGNEEIIHVLIG-PCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIA 724
            RPIH+AC   +I++VKLLIDH+C+IEA D  G RPIH+AC   H EIVKLLID+ CDIEALD    RPIH+AC   H E VKLLI H+CDIEA DE GWRPIHHA + G    V LLID HCDI + D   N  PI  A   G+ EI+ +LI   C + A  N     +        I+    +I+     E      KRRPIH+AC    I++VK LI   C+I A D+   RP+  A
Sbjct:   38 RPIHHACSAGHIDIVKLLIDHNCDIEAIDALGLRPIHHACRIGHTEIVKLLIDHFCDIEALDALGLRPIHHACRIGHTEIVKLLIDHYCDIEACDESGWRPIHHATNKGQTGIVKLLIDCHCDIESRDNWWNRMPIHHACSVGHIEIVKLLIDHHCDVEARDNSGWRPIHHACKEKFIDIIKLLIDHHCDIE-AGDEWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYA 275          
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000017196.1 (SMESG000017196.1)

HSP 1 Score: 796.193 bits (2055), Expect = 0.000e+0
Identity = 411/580 (70.86%), Postives = 463/580 (79.83%), Query Frame = 2
Query:   14 RPIHYACREEYIELVKLLIDHHCNIEA------------------SDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAIXXXXXXXXXXXXXXXXXQQ----------------ISMMGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEF 1651
            RPIH+AC+E++I+++KLLIDHHC+IEA                  SDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKV              +RRPIHWACESGNI++VK LIK+KC IT KDK +L PLDIA + +NKELV+++K+  L Q+                I  MGL+C   FC+HRLC TSL+N +F KGS+IG G  G IYKCKGSG D VFA+K   L  IS+KY+E NI  FLPKL H+RII+YFGAI   D LCIFMEY  +G+LEDEI++K F+  +NIIRYSKQILEGLEFLHGN IIHRDIKP+NI+M  +N+IKLADFGISRSL+RT G  T+  T  GT NF APEVIL SD+G PYTESADIWSMGATVINMITG+PPYY     A+I +I+++KKLELP S+LMS+ MK FIEEMLNPDPD+RSTA  LL LK FSEF
Sbjct:  204 RPIHHACKEKFIDIIKLLIDHHCDIEAVETAANSLRVQRRVYRITSDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKV--------------QRRPIHWACESGNIELVKLLIKSKCKITIKDKSDLSPLDIARRNDNKELVQVIKDAILVQEPERELELERQEQVEKLIVAMGLKC-TAFCDHRLCPTSLRNLSFEKGSKIGIGSCGMIYKCKGSGTDKVFAVKRTVLYDISQKYVEGNIYKFLPKLNHQRIIKYFGAILMDDRLCIFMEYFSEGTLEDEIKRKIFLTRENIIRYSKQILEGLEFLHGNSIIHRDIKPSNIMMTSDNDIKLADFGISRSLLRTNGLATRPATIAGTLNFIAPEVILASDDGAPYTESADIWSMGATVINMITGKPPYYNSITPALIFKIASTKKLELPNSQLMSEEMKEFIEEMLNPDPDKRSTAKNLLTLKLFSEF 768          

HSP 2 Score: 191.815 bits (486), Expect = 6.305e-52
Identity = 120/271 (44.28%), Postives = 148/271 (54.61%), Query Frame = 2
Query:   14 RPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWR----------------------------------PIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIA 724
            RPIH+AC   +I++VKLLIDH+C+IEA D  G RPIH+AC   H EIVKLLID+ CDIEALD    RPIH+AC   H E VKLLI H+CDIEA DE GWR                                  PIHHAC +G IE V LLID+HCD+ A D SG  PI  A +    +II +LI         + D+E V    N   ++   +V    + R         RPIH+AC + +I+IVK LI   CDI A D+   RP+  A
Sbjct:   38 RPIHHACSAGHIDIVKLLIDHNCDIEAIDALGLRPIHHACRIGHTEIVKLLIDHFCDIEALDALGLRPIHHACRIGHTEIVKLLIDHYCDIEACDESGWRPIHHATNKGQTGIVKLLIDCHCDIESRDNWWNRMPIHHACSVGHIEIVKLLIDHHCDVEARDNSGWRPIHHACKEKFIDIIKLLID-------HHCDIEAVETAANSLRVQR--RVYRITSDR------SGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYA 293          

HSP 3 Score: 141.354 bits (355), Expect = 6.818e-35
Identity = 81/173 (46.82%), Postives = 100/173 (57.80%), Query Frame = 2
Query:    2 QWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLI-------------------THHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVL 463
            +WKRRPIHYAC  ++ E VKLLI HHC+IEA D  GWRPIH+AC    IE V LLIDYHCDI ALD+    PI  A    ++E + +LI                    +   IE  D+   RPIH AC  G+IE V LLI   C I   DKS  SP++IA R  N+E++ V+
Sbjct:  284 RWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVQRRPIHWACESGNIELVKLLIKSKCKITIKDKSDLSPLDIARRNDNKELVQVI 456          
BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Match: SMESG000017261.1 (SMESG000017261.1)

HSP 1 Score: 779.63 bits (2012), Expect = 0.000e+0
Identity = 399/550 (72.55%), Postives = 448/550 (81.45%), Query Frame = 2
Query:   11 RRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAIXXXXXXXXXXXXXXXXXQQISMMGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTVFAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFMEYLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPANILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDNGPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPESELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEFDFD 1660
            RRPIH AC + + E VKLLI+H+C+IEA D    RPIHYAC   H E VKLLI++ CDIEA D W +RPIHYAC     EAVKLLI H CDIEA DEW  RPIHHAC  G  E V LLI+  CDI ALD+SG+SP+EIAV+  NE IIH+L GPCLL AC NGDL+KVS +LNG+ IEYCDK               +RRPIHWACESGNIK+VKSLIKTKCDI+A+DK NL PLDIAIK +NKELVE+LK EELEQQI MMGL+CK  FCNHRLC TSL+ KTF KGSEIGSG FGH+YKCKGSGIDTVFA+KWIEL KI  K IEENIN FLPKL H+RII+YFGAIQT+DHLCIFMEYL  GSLEDEI++KR +AT+NIIRYSKQILEGLEFLHGN IIHRDIKP NILM   NNIK+ DFG+SRSL+RTCG +TKA TTIGTPNFTAPEV LTSD GPPYT SADIWS+GATVINMITGRPPY  CHP+AV+ +I+ +KKL+LP+S+ MS  MK FIE+ML+PDPDQRSTAAQLLKLK FSEFD D
Sbjct:  103 RRPIHLACYQGHSEAVKLLIEHNCDIEALDVWNLRPIHYACYQGHSEAVKLLIEHKCDIEAFDWWNQRPIHYACYQGRSEAVKLLIEHKCDIEAIDEWNQRPIHHACDQGHSEAVKLLIENKCDIEALDESGDSPMEIAVKSHNERIIHILNGPCLLRACKNGDLKKVSTYLNGAAIEYCDK--------------DQRRPIHWACESGNIKVVKSLIKTKCDISARDKSNLSPLDIAIKNQNKELVELLKAEELEQQILMMGLKCKS-FCNHRLCNTSLRKKTFDKGSEIGSGAFGHVYKCKGSGIDTVFAVKWIELKKIGVKCIEENINKFLPKLNHQRIIKYFGAIQTEDHLCIFMEYLSGGSLEDEIKRKRSLATENIIRYSKQILEGLEFLHGNNIIHRDIKPDNILMSNGNNIKITDFGVSRSLLRTCGNVTKAETTIGTPNFTAPEVFLTSDEGPPYTVSADIWSLGATVINMITGRPPYCGCHPYAVVKKIADTKKLDLPDSQSMSKEMKEFIEKMLDPDPDQRSTAAQLLKLKLFSEFDQD 637          

HSP 2 Score: 162.155 bits (409), Expect = 3.047e-42
Identity = 100/228 (43.86%), Postives = 127/228 (55.70%), Query Frame = 2
Query:   86 IEASDRSGWRPIHYACMARHIEIVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEIIHVLIG-PC------------LLLACTNGDLEKVSKFL-NGSTIEYCDKVIEWLTGRE*VNI*GKRRPIHWACESGNIKIVKSLIKTKCDITAKDKDNLRPLDIAI 727
            +E  D   W PIH+AC A H EIVKLLI+++CDIEALD+  +RPIH AC     EAVKLLI H CDIEA D+   RPIH AC+ G  E V LLI+++CDI ALD     PI  A   G+ E + +LI   C            +  AC  G  E V   + +   IE  D   EW            +RPIH AC+ G+ + VK LI+ KCDI A D+    P++IA+
Sbjct:   29 LERKDADLWSPIHHACFAGHAEIVKLLIEHNCDIEALDKRNQRPIHLACDQGRSEAVKLLIEHKCDIEALDKRNRRPIHLACYQGHSEAVKLLIEHNCDIEALDVWNLRPIHYACYQGHSEAVKLLIEHKCDIEAFDWWNQRPIHYACYQGRSEAVKLLIEHKCDIEAID---EW-----------NQRPIHHACDQGHSEAVKLLIENKCDIEALDESGDSPMEIAV 242          

HSP 3 Score: 77.0258 bits (188), Expect = 2.105e-14
Identity = 49/140 (35.00%), Postives = 74/140 (52.86%), Query Frame = 2
Query:    2 QWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIEIVKLL----------------IDYHCD---IEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDEWGWRPIHHACHLGSIETVNLL 364
            +W +RPIH+AC + + E VKLLI++ C+IEA D SG  P+  A  + +  I+ +L                +  + +   IE  D+ +RRPIH+AC + + + VK LI   CDI A D+    P+  A    + E V LL
Sbjct:  199 EWNQRPIHHACDQGHSEAVKLLIENKCDIEALDESGDSPMEIAVKSHNERIIHILNGPCLLRACKNGDLKKVSTYLNGAAIEYCDKDQRRPIHWACESGNIKVVKSLIKTKCDISARDKSNLSPLDIAIKNQNKELVELL 338          
The following BLAST results are available for this feature:
BLAST of Protein kinase domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP3K42.158e-3935.05mitogen-activated protein kinase kinase kinase 4 [... [more]
MAP3K42.695e-3935.05mitogen-activated protein kinase kinase kinase 4 [... [more]
MAP3K42.778e-3935.05mitogen-activated protein kinase kinase kinase 4 [... [more]
MAP3K42.823e-3935.05mitogen-activated protein kinase kinase kinase 4 [... [more]
MAP3K21.035e-3836.96mitogen-activated protein kinase kinase kinase 2 [... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
gck-12.565e-3837.02Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
gck-12.627e-3837.02Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
gck-13.080e-3837.02Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
gck-16.775e-3837.02Germinal center kinase 1 [Source:UniProtKB/Swiss-... [more]
pak-11.582e-3533.08Serine/threonine-protein kinase pak-1 [Source:Uni... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Pak8.969e-3833.08gene:FBgn0267698 transcript:FBtr0334539[more]
Pak8.969e-3833.08gene:FBgn0267698 transcript:FBtr0081714[more]
Pak8.969e-3833.08gene:FBgn0267698 transcript:FBtr0081716[more]
Pak8.969e-3833.08gene:FBgn0267698 transcript:FBtr0081715[more]
Pak8.969e-3833.08gene:FBgn0267698 transcript:FBtr0334544[more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k38.265e-4036.13mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k39.702e-4036.13mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k31.089e-3936.13mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k191.115e-3934.42mitogen-activated protein kinase kinase kinase 19 ... [more]
map3k45.762e-3934.35mitogen-activated protein kinase kinase kinase 4 [... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
samd82.555e-4034.83sterile alpha motif domain containing 8 [Source:Xe... [more]
samd83.455e-4034.83sterile alpha motif domain containing 8 [Source:Xe... [more]
dennd1a1.009e-3935.58DENN domain containing 1A [Source:Xenbase;Acc:XB-G... [more]
dennd1a1.212e-3935.58DENN domain containing 1A [Source:Xenbase;Acc:XB-G... [more]
MAP3K21.063e-3835.98mitogen-activated protein kinase kinase kinase 2 [... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Map3k44.456e-3934.71mitogen-activated protein kinase kinase kinase 4 [... [more]
Map3k44.955e-3934.71mitogen-activated protein kinase kinase kinase 4 [... [more]
Map3k21.314e-3836.80mitogen-activated protein kinase kinase kinase 2 [... [more]
Map3k32.926e-3833.71mitogen-activated protein kinase kinase kinase 3 [... [more]
Stk251.743e-3738.81serine/threonine kinase 25 (yeast) [Source:MGI Sym... [more]
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BLAST of Protein kinase domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q54PX0|Y4251_DICDI2.774e-4135.19Probable serine/threonine-protein kinase DDB_G0284... [more]
sp|F4HRJ4|M3K3A_ARATH1.676e-3935.82Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|O22042|M3K3_ARATH9.851e-3936.15Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|Q9Y6R4|M3K4_HUMAN1.356e-3835.05Mitogen-activated protein kinase kinase kinase 4 O... [more]
sp|O08648|M3K4_MOUSE3.466e-3834.71Mitogen-activated protein kinase kinase kinase 4 O... [more]
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BLAST of Protein kinase domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0H3YJG22.428e-6133.71Slc42a-1 OS=Schmidtea mediterranea OX=79327 GN=slc... [more]
A0A2C9JTY91.613e-4739.34Protein kinase domain-containing protein OS=Biomph... [more]
A0A210PFZ51.676e-4636.50Mitogen-activated protein kinase kinase kinase 2 O... [more]
C3Z0I83.143e-4539.33Uncharacterized protein (Fragment) OS=Branchiostom... [more]
A0A0R3RIB63.400e-4437.27Protein kinase domain-containing protein OS=Elaeop... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k31.013e-4035.79mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k31.013e-4035.79mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k31.013e-4035.79mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k221.676e-3934.57mitogen-activated protein kinase kinase kinase 3-l... [more]
map3k222.005e-3934.57mitogen-activated protein kinase kinase kinase 3-l... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k21.767e-4437.50mitogen-activated protein kinase kinase kinase 2 [... [more]
stk25a1.586e-3537.79serine/threonine kinase 25a [Source:ZFIN;Acc:ZDB-G... [more]
slka2.930e-3334.22STE20-like kinase a [Source:ZFIN;Acc:ZDB-GENE-0504... [more]
MAP4K32.340e-3229.96mitogen-activated protein kinase kinase kinase kin... [more]
pak42.009e-3130.89p21 protein (Cdc42/Rac)-activated kinase 4 [Source... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
STE201.280e-3432.26Cdc42p-activated signal transducing kinase; involv... [more]
CDC158.853e-3234.78Protein kinase of the Mitotic Exit Network; locali... [more]
SSK221.565e-3132.85MAP kinase kinase kinase of HOG1 mitogen-activated... [more]
SPS17.826e-3133.09Putative protein serine/threonine kinase; localize... [more]
KIC19.474e-3135.36Protein kinase of the PAK/Ste20 family, required f... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO414107.198e-4839.03Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO319342.251e-3737.22Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO336675.218e-3632.95Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO478211.678e-3532.61Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO428452.554e-3534.63Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Protein kinase domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k228.013e-4033.94mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k31.085e-3936.30mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k221.118e-3933.94mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k221.118e-3933.94mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k24.002e-3935.98mitogen-activated protein kinase kinase kinase 2 [... [more]
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BLAST of Protein kinase domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000032703.14.513e-5784.81SMESG000032703.1[more]
SMESG000017196.14.287e-5574.56SMESG000017196.1[more]
SMESG000017196.15.556e-5374.56SMESG000017196.1[more]
SMESG000017196.16.305e-5270.86SMESG000017196.1[more]
SMESG000017261.13.047e-4272.55SMESG000017261.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30028483 ID=SMED30028483|Name=Protein kinase domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1913bp
GCAGTGGAAACGGCGGCCAATTCATTACGCATGCAGAGAAGAGTATATAG
AATTAGTCAAATTGCTGATTGATCACCATTGTAATATTGAAGCATCAGAT
AGGTCGGGTTGGCGGCCAATTCATTACGCTTGCATGGCAAGACACATAGA
AATTGTCAAACTGCTGATTGATTACCATTGCGATATTGAGGCACTTGACA
GGTGGAAGCGACGGCCAATTCATTACGCATGCAGTGCAGACCACAAAGAG
GCAGTAAAACTGTTGATTACTCACCATTGTGATATTGAGGCATTTGATGA
GTGGGGTTGGCGGCCAATTCATCACGCGTGCCATTTAGGGAGTATAGAGA
CAGTAAATCTTCTGATTGATTATCATTGTGATATCGGAGCACTTGATAAA
TCTGGTAATTCACCCATCGAAATTGCTGTGAGATATGGCAATGAAGAAAT
TATTCACGTTCTTATTGGGCCTTGCTTGCTGCTAGCGTGTACAAATGGCG
ACCTGGAGAAGGTTTCCAAGTTTCTAAATGGTTCCACCATTGAATATTGT
GATAAGGTGATTGAATGGTTGACTGGAAGGGAATAAGTAAATATTTAGGG
CAAAAGGCGTCCAATTCATTGGGCATGTGAAAGCGGTAATATAAAAATTG
TCAAATCACTGATTAAAACAAAATGCGATATAACTGCGAAAGATAAAGAT
AATTTGCGTCCTCTGGACATCGCTATAAAGAAGGAAAATAAGGAGCTCGT
TGAGATCCTCAAGGAAGAAGAATTGGAACAACAAATTTCAATGATGGGCC
TGGAATGCAAACCGCCGTTTTGTAACCACCGGCTCTGCAAGACATCTCTC
AAGAATAAGACATTTGCGAAAGGTTCAGAAATTGGAAGTGGGGGATTTGG
GCATATTTATAAGTGCAAGGGGTCTGGAATAGACACAGTTTTTGCTATCA
AGTGGATAGAATTAATAAAGATCAGTGAGAAATACATCGAAGAAAATATT
AATACATTTCTACCCAAACTCATGCATAAAAGAATCATCAGATATTTTGG
AGCCATCCAAACAAAAGATCATTTATGCATATTTATGGAATACCTTTTTA
AAGGCTCATTGGAAGATGAAATCGAAAAGAAAAGATTCATAGCCACAAAG
AATATCATAAGGTACAGCAAGCAAATCCTCGAAGGCCTGGAATTTCTGCA
TGGGAATAGAATTATTCATCGAGATATAAAGCCGGCAAATATATTGATGG
GCCCCGAGAATAATATAAAATTGGCAGATTTCGGTATCAGCCGGTCATTA
ATGAGGACTTGTGGCGAAATAACTAAAGCTGTCACAACCATTGGAACTCC
CAATTTTACAGCTCCTGAGGTTATCTTGACTAGTGATAATGGGCCACCCT
ACACTGAGTCAGCTGATATCTGGTCTATGGGGGCCACTGTTATCAATATG
ATTACTGGGAGGCCGCCATATTACTATTGCCACCCATTTGCTGTCATAAA
CAGAATCTCCACAAGTAAAAAGCTTGAACTTCCGGAATCCGAACTAATGT
CAGACGCAATGAAAGGCTTCATAGAAGAAATGTTGAATCCAGATCCAGAT
CAGAGATCAACCGCAGCGCAATTATTAAAATTGAAATTTTTTTCTGAATT
TGATTTCGATTGAACATATTTTTATATCTGGTTTTGATTTTTGGATTTTC
TGAATAATATTTTGTTTAAATGGATGGAATTATATTTATGTAAATTTGGC
AAGTAGAATGTTTTATTCAGCCTGACATGCTTTGAATGCTTTTACAATTT
CGGTTGTATCATAGGTAACTTTGTCCACGACAAATGGAGACCCTAATTCT
GGAGATTGATTTCCATCCTACATATCCAAATGATGTTGTGAATCCCTAAT
TTATTATAATGAT
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protein sequence of SMED30028483-orf-1

>SMED30028483-orf-1 ID=SMED30028483-orf-1|Name=SMED30028483-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=195bp
QWKRRPIHYACREEYIELVKLLIDHHCNIEASDRSGWRPIHYACMARHIE
IVKLLIDYHCDIEALDRWKRRPIHYACSADHKEAVKLLITHHCDIEAFDE
WGWRPIHHACHLGSIETVNLLIDYHCDIGALDKSGNSPIEIAVRYGNEEI
IHVLIGPCLLLACTNGDLEKVSKFLNGSTIEYCDKVIEWLTGRE*
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protein sequence of SMED30028483-orf-2

>SMED30028483-orf-2 ID=SMED30028483-orf-2|Name=SMED30028483-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=291bp
MMGLECKPPFCNHRLCKTSLKNKTFAKGSEIGSGGFGHIYKCKGSGIDTV
FAIKWIELIKISEKYIEENINTFLPKLMHKRIIRYFGAIQTKDHLCIFME
YLFKGSLEDEIEKKRFIATKNIIRYSKQILEGLEFLHGNRIIHRDIKPAN
ILMGPENNIKLADFGISRSLMRTCGEITKAVTTIGTPNFTAPEVILTSDN
GPPYTESADIWSMGATVINMITGRPPYYYCHPFAVINRISTSKKLELPES
ELMSDAMKGFIEEMLNPDPDQRSTAAQLLKLKFFSEFDFD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: INTERPRO
TermDefinition
IPR002110Ankyrin_rpt
IPR020683Ankyrin_rpt-contain_dom
IPR000719Prot_kinase_dom
IPR008271Ser/Thr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR011009Kinase-like_dom_sf
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0000166nucleotide binding
GO:0000287magnesium ion binding
GO:0004674protein serine/threonine kinase activity
GO:0008134transcription factor binding
GO:0016301kinase activity
GO:0016740transferase activity
GO:0042802identical protein binding
GO:0042803protein homodimerization activity
GO:0046872metal ion binding
GO:0046983protein dimerization activity
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0000902cell morphogenesis
GO:0001569branching involved in blood vessel morphogenesis
GO:0001841neural tube formation
GO:0001934positive regulation of protein phosphorylation
GO:0003157endocardium development
GO:0006915apoptotic process
GO:0007165signal transduction
GO:0007417central nervous system development
GO:0008285negative regulation of cell proliferation
GO:0016310phosphorylation
GO:0018105peptidyl-serine phosphorylation
GO:0030216keratinocyte differentiation
GO:0032092positive regulation of protein binding
GO:0033138positive regulation of peptidyl-serine phosphorylation
GO:0035329hippo signaling
GO:0035556intracellular signal transduction
GO:0043065positive regulation of apoptotic process
GO:0045600positive regulation of fat cell differentiation
GO:0046621negative regulation of organ growth
GO:0046777protein autophosphorylation
GO:0050821protein stabilization
GO:0060215primitive hemopoiesis
GO:0060706cell differentiation involved in embryonic placenta development
GO:0060800regulation of cell differentiation involved in embryonic placenta development
GO:0090090negative regulation of canonical Wnt signaling pathway
GO:0097284hepatocyte apoptotic process
GO:1902043positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005654nucleoplasm
GO:0005737cytoplasm
GO:0005829cytosol
GO:0016604nuclear body
GO:0043234protein complex
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 25..284
e-value: 2.0E-72
score: 256.6
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 26..284
e-value: 6.7E-63
score: 212.5
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 25..284
score: 45.531
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 21..289
e-value: 1.1E-73
score: 249.8
NoneNo IPR availablePIRSFPIRSF000654ILKcoord: 11..282
e-value: 4.3E-30
score: 102.4
NoneNo IPR availablePANTHERPTHR45832:SF5coord: 21..284
NoneNo IPR availablePANTHERPTHR45832FAMILY NOT NAMEDcoord: 21..284
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 141..153
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 31..54
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 23..288