BEN domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30028469 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 6
Homology
BLAST of BEN domain-containing protein vs. TrEMBL
Match: A0A4Z2CZR1 (BEN domain isoform 2 OS=Schistosoma japonicum OX=6182 GN=EWB00_006211 PE=4 SV=1) HSP 1 Score: 179.489 bits (454), Expect = 1.749e-46 Identity = 79/129 (61.24%), Postives = 105/129 (81.40%), Query Frame = 1 Query: 562 NLTVKRKTFRGTSDEENEIDTTFKPIEINNEVILSKNYSDIRVGKDLFYMMLLKASNSATRLIRLLMKNFFCQKELEVSSLSGEGYYKQKLNPQIITAIKEFIKTRHPKLKNGSINLCMTDVCVQARRV 948 N + K+ FRGTS+EEN++ FKP+E+NN+++LS+ + ++++ KD+FY +++K+S SATRLIRLLMK+FF Q EL SSLSGEG YKQ+L P + AIK FI+ RHP+LK GSINLCMTDVCVQARRV Sbjct: 527 NSSPKKSNFRGTSEEENKVAPNFKPVEVNNQILLSEAHPNVKLSKDIFYSLIVKSSGSATRLIRLLMKSFFTQDELAASSLSGEGIYKQRLEPSVTEAIKIFIRQRHPQLKTGSINLCMTDVCVQARRV 655
BLAST of BEN domain-containing protein vs. TrEMBL
Match: A0A068WX88 (BEN domain OS=Echinococcus granulosus OX=6210 GN=EgrG_000333200 PE=4 SV=1) HSP 1 Score: 173.326 bits (438), Expect = 1.918e-46 Identity = 83/146 (56.85%), Postives = 107/146 (73.29%), Query Frame = 1 Query: 556 SSNLTVKRKTFRGTSDEENEIDTTFKPIEINNEVILSKNYSDIRVGKDLFYMMLLKASNSATRLIRLLMKNFFCQKELEVSSLSGEGYYKQKLNPQIITAIKEFIKTRHPKLKNGSINLCMTDVCVQARRVY-----RTKDPKTKL 978 S L K+ +FRGTS+EENE+ FKP+E N +ILS+ + + + K+++ +++K+S SATRLIRLLMK+FF Q+EL SSLSGEG YKQ+L P+I AIK FI+ RHP+LK GSINLCMTDVCVQARRV R + PK L Sbjct: 212 SGPLLSKKPSFRGTSEEENEVCPHFKPVEQNGHIILSELHPSVMLPKEVYQSLIIKSSGSATRLIRLLMKSFFSQEELAASSLSGEGIYKQRLQPEITEAIKAFIRKRHPQLKTGSINLCMTDVCVQARRVANNQRSRVRGPKKPL 357
BLAST of BEN domain-containing protein vs. TrEMBL
Match: A0A068XZR7 (BEN domain OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000333200 PE=4 SV=1) HSP 1 Score: 172.94 bits (437), Expect = 2.573e-46 Identity = 83/146 (56.85%), Postives = 107/146 (73.29%), Query Frame = 1 Query: 556 SSNLTVKRKTFRGTSDEENEIDTTFKPIEINNEVILSKNYSDIRVGKDLFYMMLLKASNSATRLIRLLMKNFFCQKELEVSSLSGEGYYKQKLNPQIITAIKEFIKTRHPKLKNGSINLCMTDVCVQARRVY-----RTKDPKTKL 978 S L K+ +FRGTS+EENE+ FKP+E N +ILS+ + + + K+++ +++K+S SATRLIRLLMK+FF Q+EL SSLSGEG YKQ+L P+I AIK FI+ RHP+LK GSINLCMTDVCVQARRV R + PK L Sbjct: 212 SGPLLSKKPSFRGTSEEENEVCPHFKPVEQNGHIILSELHPSVMLPKEVYQSLIIKSSGSATRLIRLLMKSFFSQEELAASSLSGEGIYKQRLQPEITEAIKAFIRKRHPQLKTGSINLCMTDVCVQARRVANNQRSRVRGPKKPL 357
BLAST of BEN domain-containing protein vs. TrEMBL
Match: A0A5K4F236 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 PE=4 SV=1) HSP 1 Score: 178.333 bits (451), Expect = 4.518e-46 Identity = 82/146 (56.16%), Postives = 111/146 (76.03%), Query Frame = 1 Query: 562 NLTVKRKTFRGTSDEENEIDTTFKPIEINNEVILSKNYSDIRVGKDLFYMMLLKASNSATRLIRLLMKNFFCQKELEVSSLSGEGYYKQKLNPQIITAIKEFIKTRHPKLKNGSINLCMTDVCVQARRVYRTKDPKTKLLTNQ*TI 999 N + K+ FRGTS+EEN++ FKPIE+N++++LS+ + ++++ KD+FY +++K+S SATRLIRLLMK+FF Q EL SSLSGEG YKQ+L P + AIK FI+ RHP+LK GSINLCMTDVCVQARRV + + L N T+ Sbjct: 526 NSSPKKSNFRGTSEEENKVAPNFKPIEVNSQILLSEAHPNVKLSKDIFYSLIVKSSGSATRLIRLLMKSFFTQDELAASSLSGEGIYKQRLEPSVTEAIKIFIRQRHPQLKTGSINLCMTDVCVQARRVANNQRSRQHPLRNSPTM 671
BLAST of BEN domain-containing protein vs. TrEMBL
Match: A0A4S2LI88 (BEN domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_007401 PE=4 SV=1) HSP 1 Score: 177.563 bits (449), Expect = 8.179e-46 Identity = 80/125 (64.00%), Postives = 99/125 (79.20%), Query Frame = 1 Query: 574 KRKTFRGTSDEENEIDTTFKPIEINNEVILSKNYSDIRVGKDLFYMMLLKASNSATRLIRLLMKNFFCQKELEVSSLSGEGYYKQKLNPQIITAIKEFIKTRHPKLKNGSINLCMTDVCVQARRV 948 K+ FRGTS+EENE+ FKP E N ++ILS + ++++ KD+FY +++K+S SATRLIRLLMK+FF Q EL SSLSGEG YKQ+L P I AIK FI+ RHP+LK GSINLCMTDVCVQARRV Sbjct: 507 KKSNFRGTSEEENEVSPDFKPTEFNGQIILSDAHPNVKLSKDIFYSLIVKSSGSATRLIRLLMKSFFTQDELAASSLSGEGIYKQRLEPSITEAIKIFIRKRHPQLKTGSINLCMTDVCVQARRV 631
BLAST of BEN domain-containing protein vs. Planmine SMEST
Match: SMESG000000832.1 (SMESG000000832.1) HSP 1 Score: 611.298 bits (1575), Expect = 0.000e+0 Identity = 297/298 (99.66%), Postives = 298/298 (100.00%), Query Frame = 1 Query: 97 MTSNNCHRRKNKIPRKRDYTCLKYTTSNEDKETETSNSIDFNADYQKQNSIEDPSQSNNENFQTEINRSFKSNHSQYSAVHLIHSVLPVPRFQFHPNLQTLYEEIRSTCVNIDQMIDKYMKAYASTILQNISSTNSSPVSPDISPSLNGSMNKSSNLTVKRKTFRGTSDEENEIDTTFKPIEINNEVILSKNYSDIRVGKDLFYMMLLKASNSATRLIRLLMKNFFCQKELEVSSLSGEGYYKQKLNPQIITAIKEFIKTRHPKLKNGSINLCMTDVCVQARRVYRTKDPKTKLLTNQ 990 MTSNNCHRRKNKIPRKRDYTCLKYTTSNEDKETETSNSIDFNADYQKQNSIEDPSQSNNENFQTEINRSFKSN+SQYSAVHLIHSVLPVPRFQFHPNLQTLYEEIRSTCVNIDQMIDKYMKAYASTILQNISSTNSSPVSPDISPSLNGSMNKSSNLTVKRKTFRGTSDEENEIDTTFKPIEINNEVILSKNYSDIRVGKDLFYMMLLKASNSATRLIRLLMKNFFCQKELEVSSLSGEGYYKQKLNPQIITAIKEFIKTRHPKLKNGSINLCMTDVCVQARRVYRTKDPKTKLLTNQ Sbjct: 1 MTSNNCHRRKNKIPRKRDYTCLKYTTSNEDKETETSNSIDFNADYQKQNSIEDPSQSNNENFQTEINRSFKSNYSQYSAVHLIHSVLPVPRFQFHPNLQTLYEEIRSTCVNIDQMIDKYMKAYASTILQNISSTNSSPVSPDISPSLNGSMNKSSNLTVKRKTFRGTSDEENEIDTTFKPIEINNEVILSKNYSDIRVGKDLFYMMLLKASNSATRLIRLLMKNFFCQKELEVSSLSGEGYYKQKLNPQIITAIKEFIKTRHPKLKNGSINLCMTDVCVQARRVYRTKDPKTKLLTNQ 298
BLAST of BEN domain-containing protein vs. Planmine SMEST
Match: SMESG000080064.1 (SMESG000080064.1) HSP 1 Score: 173.326 bits (438), Expect = 6.827e-49 Identity = 85/135 (62.96%), Postives = 101/135 (74.81%), Query Frame = 1 Query: 574 KRKTFRGTSDEENEIDTTFKPIEINNEVILSKNYSDIRVGKDLFYMMLLKASNSATRLIRLLMKNFFCQKELEVSSLSGEGYYKQKLNPQIITAIKEFIKTRHPKLKNGSINLCMTDVCVQARRVYRTKDPKTKL 978 K+ FRGTS+ ENEIDT F P E+N E+IL YS +R+ K+++ + KA SATRLIRLLMK+FF Q L SSLSGEG YK +L P +I AIK FIK RHPKLKNGSINLCMTDVCVQARRV K+ +T+L Sbjct: 333 KKSNFRGTSEAENEIDTAFIPREVNREIILCDEYSSVRLDKEVYNTLTSKAPRSATRLIRLLMKHFFSQDTLARSSLSGEGIYKDRLQPDVIEAIKLFIKRRHPKLKNGSINLCMTDVCVQARRV--NKNQRTRL 465 The following BLAST results are available for this feature:
BLAST of BEN domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of BEN domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of BEN domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of BEN domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of BEN domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of BEN domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of BEN domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of BEN domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of BEN domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of BEN domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of BEN domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of BEN domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of BEN domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of BEN domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30028469 ID=SMED30028469|Name=BEN domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1102bpback to top protein sequence of SMED30028469-orf-1 >SMED30028469-orf-1 ID=SMED30028469-orf-1|Name=SMED30028469-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=299bp MTSNNCHRRKNKIPRKRDYTCLKYTTSNEDKETETSNSIDFNADYQKQNSback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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