Bardet-Biedl syndrome 1 protein homolog

Overview
NameBardet-Biedl syndrome 1 protein homolog
Smed IDSMED30028417
Uniprot Best hitBardet-Biedl syndrome 1 protein homolog OS=Mus musculus OX=10090 GN=Bbs1 PE=1 SV=1 (E=8.52587e-178)
Length (bp)1889
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Bardet-Biedl syndrome 1 protein homolog (SMED30028417) t-SNE clustered cells

Violin plots show distribution of expression levels for Bardet-Biedl syndrome 1 protein homolog (SMED30028417) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Bardet-Biedl syndrome 1 protein homolog (SMED30028417) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Bardet-Biedl syndrome 1 protein homolog (SMED30028417) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30028417

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 12

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
headSMED30028417SMESG000009880.1 SmedASXL_013059SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016
whole organism asexual adult RNA-sequencing evidence
pharynxSMED30028417SMESG000009880.1 dd_Smed_v4_7298_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
neuronSMED30028417SMESG000009880.1 dd_Smed_v4_7298_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult single-cell RNA-sequencing evidence
neuronSMED30028417SMESG000009880.1 dd_Smed_v4_7298_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
whole organism asexual adult colorimetric in situ hybridization evidence
headSMED30028417SMESG000009880.1 dd_Smed_v6_7298_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
Category 2 cellSMED30028417SMESG000009880.1 dd_Smed_v4_7298_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult fluorescence in situ hybridization evidence
epidermisSMED30028417SMESG000009880.1 dd_Smed_v4_7298_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Category 3 cellSMED30028417SMESG000009880.1 dd_Smed_v4_7298_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult fluorescence in situ hybridization evidence
ventral epidermisSMED30028417SMESG000009880.1 dd_Smed_v4_7298_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult fluorescence in situ hybridization evidence
pharynxSMED30028417SMESG000009880.1 EG344641.1ncbi_smed_estsPMID:19852954
Glazer et al., 2010
whole organism asexual adult colorimetric in situ hybridization evidence
cephalic gangliaSMED30028417SMESG000009880.1 EG344641.1ncbi_smed_estsPMID:19852954
Glazer et al., 2010
whole organism asexual adult colorimetric in situ hybridization evidence
dorsal stripeSMED30028417SMESG000009880.1 EG344641.1ncbi_smed_estsPMID:19852954
Glazer et al., 2010
whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Human
Match: BBS1 (Bardet-Biedl syndrome 1 [Source:HGNC Symbol;Acc:HGNC:966])

HSP 1 Score: 508.064 bits (1307), Expect = 1.369e-173
Identity = 254/582 (43.64%), Postives = 385/582 (66.15%), Query Frame = 3
Query:   75 DKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            +  E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G  +  E+ +  LP    +F ++++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  ED ++   LKE L+ +R  A   LS++S+R L L   +ME F N +KS  +K+QTV T +TTLKK+ +++DA+SCLV+GTE  +LLV+DPEAFT+L  ++  ++PVF+   G +DVEFR+  ACRNGNIY+++R     K  I+L+ QP+ ++RV+K L+VG   D+L  F+ KG+++W   +PA +++M  L+    G+Q  +  L N  + IY ++ L++ I   D VT L FG++GRE   L+M TR G LIIK+LKRTA F    S  GPP AQ  KLN+P+KT+L++DQ  RERE   A+HR F  DL  LR+  AR+Y++ LE+  +P+S+   +P+ L   V G+GPTFK+ + ++N+S       L + F+Y+  +Y++  +  +VPLLVPG++YP   +VE +S+KGI+D IKVLVL+  ++ P+++  VNMP SE   A+
Sbjct:   15 ESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDL---GPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA 593          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Human
Match: AP002748.5 (novel protein)

HSP 1 Score: 507.294 bits (1305), Expect = 8.480e-173
Identity = 254/579 (43.87%), Postives = 384/579 (66.32%), Query Frame = 3
Query:   84 EKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G  +  E+ +  LP    +F ++++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  ED ++   LKE L+ +R  A   LS++S+R L L   +ME F N +KS  +K+QTV T +TTLKK+ +++DA+SCLV+GTE  +LLV+DPEAFT+L  ++  ++PVF+   G +DVEFR+  ACRNGNIY+++R     K  I+L+ QP+ ++RV+K L+VG   D+L  F+ KG+++W   +PA +++M  L+    G+Q  +  L N  + IY ++ L++ I   D VT L FG++GRE   L+M TR G LIIK+LKRTA F    S  GPP AQ  KLN+P+KT+L++DQ  RERE   A+HR F  DL  LR+  AR+Y++ LE+  +P+S+   +P+ L   V G+GPTFK+ + ++N+S       L + F+Y+  +Y++  +  +VPLLVPG++YP   +VE +S+KGI+D IKVLVL+  ++ P+++  VNMP SE   A+
Sbjct:   55 EANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDL---GPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA 630          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Human
Match: BBS1 (Bardet-Biedl syndrome 1 [Source:HGNC Symbol;Acc:HGNC:966])

HSP 1 Score: 308.145 bits (788), Expect = 3.238e-97
Identity = 150/352 (42.61%), Postives = 231/352 (65.62%), Query Frame = 3
Query:  762 VTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            ++  ++PVF+   G +DVEFR+  ACRNGNIY+++R     K  I+L+ QP+ ++RV+K L+VG   D+L  F+ KG+++W   +PA +++M  L+    G+Q  +  L N  + IY ++ L++ I   D VT L FG++GRE   L+M TR G LIIK+LKRTA F    S  GPP AQ  KLN+P+KT+L++DQ  RERE   A+HR F  DL  LR+  AR+Y++ LE+  +P+S+   +P+ L   V G+GPTFK+ + ++N+S       L + F+Y+  +Y++  +  +VPLLVPG++YP   +VE +S+KGI+D IKVLVL+  ++ P+++  VNMP SE   A+
Sbjct:  145 MSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA 496          

HSP 2 Score: 119.013 bits (297), Expect = 9.286e-28
Identity = 57/136 (41.91%), Postives = 87/136 (63.97%), Query Frame = 3
Query:   75 DKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSV 482
            +  E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G  +  E+ +  LP    +F ++++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  E S+
Sbjct:   15 ESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDL---GPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEMSL 147          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Human
Match: BBS1 (Bardet-Biedl syndrome 1 [Source:HGNC Symbol;Acc:HGNC:966])

HSP 1 Score: 204.912 bits (520), Expect = 1.029e-58
Identity = 117/293 (39.93%), Postives = 177/293 (60.41%), Query Frame = 3
Query:   75 DKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLR-NAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLY--AVTFNAIPVFMCTVGLYDVEFRIYVACRNGN---IYVVKRGDTVAKSLIQLNTQPLSMLRVN 935
            +  E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G  +  E+ +  LP    +F ++++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  ED ++   LKE L+ +R  A   LS++S+R L L   +ME F N +KS  +K+QTV T +TTLKK+ +++DA+SCLV+GTE  +LLV+DPEAFT+L   AVT       +C  G Y  E    +    G    I ++KR     +   ++   P   +++N
Sbjct:   15 ESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDL---GPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKDAVT------SLC-FGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLN 297          

HSP 2 Score: 176.407 bits (446), Expect = 3.935e-48
Identity = 93/200 (46.50%), Postives = 133/200 (66.50%), Query Frame = 3
Query: 1137 ISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKV 1736
            I   D VT L FG++GRE   L+M TR G LIIK+LKRTA F    S  GPP AQ  KLN+P+KT+L++DQ  RERE   A+HR F  DL  LR+  AR+Y++ LE+  +P+S+   +P+ L   V G+GPTFK+ + ++N+S       L + F+Y+  +Y++  +  +VPLLVPG++YP   +VE +S+KGI+D IKV
Sbjct:  238 ILAKDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKV 437          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Human
Match: BBS1 (Bardet-Biedl syndrome 1 [Source:HGNC Symbol;Acc:HGNC:966])

HSP 1 Score: 136.346 bits (342), Expect = 1.989e-36
Identity = 66/134 (49.25%), Postives = 98/134 (73.13%), Query Frame = 3
Query:  471 EDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKR 869
            +D ++   LKE L+ +R  A   LS++S+R L L   +ME F N +KS  +K+QTV T +TTLKK+ +++DA+SCLV+GTE  +LLV+DPEAFT+L  ++  ++PVF+   G +DVEFR+  ACRNGNIY+++R
Sbjct:   53 KDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRR 186          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Celegans
Match: bbs-1 (Bardet-Biedl syndrome 1 protein homolog [Source:UniProtKB/Swiss-Prot;Acc:Q9NEZ7])

HSP 1 Score: 259.61 bits (662), Expect = 3.373e-78
Identity = 165/561 (29.41%), Postives = 295/561 (52.58%), Query Frame = 3
Query:  129 DLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN--AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIAD-TIKVLVLKNNETDPIVTGVVNMPVSE 1802
            +++  S C+    I  D ++ L++A    H+     MKLKV++ +    E+++ D+PT +V F  D +    P +AVA+GP + +YKN+KP++KFT+PS  +   E   WK      +N + L   L  L +  A   L+  S   L    E        Y +      T+ TC+  L KS +E   +  LV+GTE  ++ +ID +AFT+L  +   ++PV +C  G YDV++R++V  R   I+ +KRG+   + ++   +   SM+ VNK ++   +++ +   S +G++M     P+  I M +           ++++ +  I +YN   L+D +     +  + +G +GRE   L++  + GS+ I++ +R A+F T+      PQA   KL IPKKTK+F+D   RE +    IH+ + ++L  ++   A SY+E+  +    +S+    P+ +++++HG GPTF+M + + +SS Q    D+ +  + D ++Y  D  +I V LL  G SY ++  + C   +  A+  ++ L++      PIVT V+ MP SE
Sbjct:   22 EIYCPSTCVAFGPILSDNDSKLIIAH-GGHRG--VNMKLKVFQQLEQLSESSLADMPTALVHFINDLSS--IPSIAVAAGPSLLIYKNLKPFYKFTVPSSAINPTESEAWKAVVNKKINGDTLLTVLKRLEDDVAFSKLTPISQTYLRADKETQVVLVEHYGTKIANSATI-TCIAKLTKSTAE--PLDILVIGTEHCEIFLIDSQAFTILETIKIGSVPVNICAYGTYDVDYRLFVQTRASLIFCMKRGEADYQPIVISQSMITSMVLVNKMIVYTTVENLIHFASFRGKKMNTVKCPSK-IKMLEPFIYPLKQLAAVIAVFDKEIRMYNEHYLLDTVQYEKPLAWVKYGCYGREDSTLVVAFKDGSIAIQIFRRKANFDTKLDYNQVPQAHALKLQIPKKTKVFIDLTQREVQLGNRIHKVYQKNLFDVKYRLAASYLELTSSASATVSTTTVLPVEISVDIHGFGPTFRMTIHLLSSSKQNL-YDMHLSIISDPELYDFDTPLIPVHLLASGQSYSFTTLLYCKDPEKAANCDVRALLVHAKRATPIVTAVIKMPFSE 572          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Fly
Match: BBS1 (gene:FBgn0035741 transcript:FBtr0076912)

HSP 1 Score: 257.299 bits (656), Expect = 5.597e-77
Identity = 158/603 (26.20%), Postives = 313/603 (51.91%), Query Frame = 3
Query:   90 SKNWL---TAHENTLADLFSISQCMCLCDINGDGENCLVVADLT-DHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGMT-LSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTF----NAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLS---MLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEK--------LNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSD-PIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQ-------VPLLXXXXXXXXXXXXECISDKGIA---DTIKVLVLKNNETDPIVTGVVNMPVSET 1805
            + NWL   TA E     L +++ CM L D+  DG   L+ AD++ D+ ++     LKV+RG+ L  E  +  +P  + S ++D  EP+TP +AVA    +  Y+++KPYFK+T+P+    + E  +W++     V        LD L+    + LS +S RLL +  ++ E F   +K  P+ +      +  +K+  S+ +  S LV+ T+ G +++++P+ F ++Y         A+P  +   G ++ +F I VA RNG +Y++++  +  + + +L   PL+   +L +++ +I   MD+   C+S +G+ ++   +    + +  L     G+    ++L    ++ Y  R L+D   + +TV  +L+G+ G E   L +VT+SG +++K+L+R + F  +  +    +A  +         L+ PKK+ +F++QA RE++ + + +  F  +L +LR T AR+ ++ + + ++ IS   +  P+ L+ EV G GP F++ ++++N S    +S+L +L   D + Y I  ++ +       VPL V          ++ +    +      I+V+++K  +  P++   ++MP SE 
Sbjct:    4 APNWLHVDTAEEAPPPHLTTLTSCMALSDVQCDGYVRLLAADISLDNAAEEPTATLKVFRGLKLKHEQPLPGIPAAIESLYIDETEPKTPVIAVAIAESVLFYRHLKPYFKYTIPAQDSEDLELEVWRKLP--VVKPSAHPALLDSLKTIDHSKLSRKSQRLLQMGEQEREHFIATHKDSPVGRVGNIVAMCCIKRISSDANPPSHLVLATDTGHIMILEPQGFNLVYQGKACDDETAVPSLISVQGTFETDFCIVVATRNGGVYLLRKSQSEGQEIFKLGI-PLTGLLLLPIDQTIIASTMDNRYLCYSKRGKLLYQVPMSDLPVCLLPLPLTHLGLTLVAIALRGGVVKFYLQRYLVDEFVLEETVDAMLYGRMGMEDHVLTLVTQSGGIVVKILRRVSRFEPKAGDLANKRALGDNKSIVDASILDKPKKSSIFVEQAAREKQQAKSTYGSFQVELWRLRHTAARATIDAINSSESTISGDLTHAPVKLSAEVCGSGPAFRLYLTVQNLSTFKMASNLVVLLHADRRHYTIPQTLARLPSVLPGVPLRVDFEVVAVLDPMDKLPPASLTPDNSLIRVMLMKAGQAKPLIAAAISMPQSEA 603          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Zebrafish
Match: bbs1 (Bardet-Biedl syndrome 1 [Source:ZFIN;Acc:ZDB-GENE-060126-1])

HSP 1 Score: 573.548 bits (1477), Expect = 0.000e+0
Identity = 274/585 (46.84%), Postives = 407/585 (69.57%), Query Frame = 3
Query:   51 SEKPTESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSE 1802
            S  P E  D    S  WL AH + +A+L++ S C+ L D++GDGEN LVV DL    +    MKLKVYRG  L  E+ ++DLPTG+VSF +D +EPRTP +AVASGP+IYVYKNM+PYFKFTLPSL +   E+++W +  ED ++   LKE L+GLR+ + + LSVRS+R LML   +ME F +++K  P+++QTV TC+ TLKK+ +++DA+SCLV+GTE G + ++DPEAFT+LY ++  + P  M   G +DVEFRI VACRNGNIY+++R     K  I+L++ P+ ++R+ K ++VGC  +TL  ++ KG+++W   LPA + +M  +D    G Q  +V L N  + +Y +++LI  I   D VT + FG++GRE   L+M T+ G LI+K+LKRTA F  + S  GPP AQ  +LN+PKKTKL++DQ  REREN++A+HR F  DL +LR+  AR+YV+ LE+   P+S+  ++P+ +   V G+GP+FK+ ++I+N++      +LAI F+YD  +Y++  +  ++PLLVPG++YP   +VEC+SDKG++D IKV VL+  ++ P++T  +NMPVSE
Sbjct:    2 SSVPQELKDTSVASSKWLDAHYDPVANLYTFSSCIALSDLHGDGENKLVVGDL---GTGLCNMKLKVYRGTGLLSESTLLDLPTGLVSFLMDLHEPRTPAIAVASGPFIYVYKNMRPYFKFTLPSLDINPLEQDVWCQAKEDMIDPMTLKEMLEGLRDKSEIPLSVRSLRFLMLEPHEMENFVHLHKEQPIRRQTVITCIGTLKKNMADEDAVSCLVIGTENGDVYILDPEAFTILYKMSLPSTPTLMDVTGQFDVEFRITVACRNGNIYILRRDSPKPKYCIELSSHPVGLVRMGKNVVVGCTHETLHGYTQKGKKLWTAYLPAPVTTMALMDLPTRGFQAVLVGLANCEVHMYRDKNLIGTIKTPDVVTSICFGRYGREDGTLIMTTKGGGLIVKILKRTAVFDDRDSTPGPPIAQSIRLNVPKKTKLYVDQTLRERENAIAMHRAFQMDLSRLRLAAARAYVKALESSLTPMSASLTEPLKMNAVVQGLGPSFKLTLNIQNTAASRPVMNLAISFLYDESLYSMRTAFFKIPLLVPGLNYPIDTFVECLSDKGVSDIIKVFVLREGKSAPLLTAHINMPVSE 583          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Zebrafish
Match: bbs1 (Bardet-Biedl syndrome 1 [Source:ZFIN;Acc:ZDB-GENE-060126-1])

HSP 1 Score: 573.548 bits (1477), Expect = 0.000e+0
Identity = 274/585 (46.84%), Postives = 407/585 (69.57%), Query Frame = 3
Query:   51 SEKPTESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSE 1802
            S  P E  D    S  WL AH + +A+L++ S C+ L D++GDGEN LVV DL    +    MKLKVYRG  L  E+ ++DLPTG+VSF +D +EPRTP +AVASGP+IYVYKNM+PYFKFTLPSL +   E+++W +  ED ++   LKE L+GLR+ + + LSVRS+R LML   +ME F +++K  P+++QTV TC+ TLKK+ +++DA+SCLV+GTE G + ++DPEAFT+LY ++  + P  M   G +DVEFRI VACRNGNIY+++R     K  I+L++ P+ ++R+ K ++VGC  +TL  ++ KG+++W   LPA + +M  +D    G Q  +V L N  + +Y +++LI  I   D VT + FG++GRE   L+M T+ G LI+K+LKRTA F  + S  GPP AQ  +LN+PKKTKL++DQ  REREN++A+HR F  DL +LR+  AR+YV+ LE+   P+S+  ++P+ +   V G+GP+FK+ ++I+N++      +LAI F+YD  +Y++  +  ++PLLVPG++YP   +VEC+SDKG++D IKV VL+  ++ P++T  +NMPVSE
Sbjct:    2 SSVPQELKDTSVASSKWLDAHYDPVANLYTFSSCIALSDLHGDGENKLVVGDL---GTGLCNMKLKVYRGTGLLSESTLLDLPTGLVSFLMDLHEPRTPAIAVASGPFIYVYKNMRPYFKFTLPSLDINPLEQDVWCQAKEDMIDPMTLKEMLEGLRDKSEIPLSVRSLRFLMLEPHEMENFVHLHKEQPIRRQTVITCIGTLKKNMADEDAVSCLVIGTENGDVYILDPEAFTILYKMSLPSTPTLMDVTGQFDVEFRITVACRNGNIYILRRDSPKPKYCIELSSHPVGLVRMGKNVVVGCTHETLHGYTQKGKKLWTAYLPAPVTTMALMDLPTRGFQAVLVGLANCEVHMYRDKNLIGTIKTPDVVTSICFGRYGREDGTLIMTTKGGGLIVKILKRTAVFDDRDSTPGPPIAQSIRLNVPKKTKLYVDQTLRERENAIAMHRAFQMDLSRLRLAAARAYVKALESSLTPMSASLTEPLKMNAVVQGLGPSFKLTLNIQNTAASRPVMNLAISFLYDESLYSMRTAFFKIPLLVPGLNYPIDTFVECLSDKGVSDIIKVFVLREGKSAPLLTAHINMPVSE 583          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Xenopus
Match: ccdc84 (coiled-coil domain containing 84 [Source:Xenbase;Acc:XB-GENE-923273])

HSP 1 Score: 561.992 bits (1447), Expect = 0.000e+0
Identity = 272/580 (46.90%), Postives = 404/580 (69.66%), Query Frame = 3
Query:   81 EEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            E +SK WL AH + +A L ++S C+ L D++GDG+  +VV D+         MKLKVY+G +   E  ++DLPTGV +F +D+NEPRTP +AVASGP+IYVYKN++PYFKFTLP++ V   E+ +W +  ED ++   LKE L+ +R+ A + LSVRS+R LML  ++ME F N YK  PLK+QTV TC+ TLKK+ +++DA+ CLV+GTE+G+L ++DPEAFT+L  V+ +++P  +   G YD+E+RI VACRNGN+Y+++R     K  I+L+ Q + ++RV K +++G   +TL  +S KG+++W  TLPA++++M  ++    G+Q  +V L N  + +Y +++L+  I+  D VTGL FG++GRE   L+M T+ G L+IK+LKRTA F  + +  GPP  Q  KLN+PKKTKL++DQ  REREN+VA+HR F  DL +LR++ AR+YV+ L+    P+SS   +P+ L   V GIGP FK+ ++++N+S+   S  L I F+YD K+Y I  +  +VPLLVPG++YP   +VEC SDKGI+D IKV VL+  ++ P++T  +NMPVSE   A+
Sbjct:   10 ESRSK-WLDAHYDPVAGLNTLSSCIALADLHGDGDFKMVVGDMGHGPY---NMKLKVYKGTARMSENALLDLPTGVAAFLMDQNEPRTPAIAVASGPFIYVYKNLRPYFKFTLPAMEVNALEKEVWDQAKEDKIDPVTLKEMLESIRDKAEIPLSVRSLRFLMLELQEMEAFVNTYKQQPLKRQTVITCMGTLKKNMADEDAVCCLVIGTESGELFILDPEAFTILTRVSLSSVPTLLDVTGQYDIEYRITVACRNGNVYILRRDSKRPKYCIELSAQVVGLVRVQKNIMIGTSHETLHGYSQKGKRLWTVTLPASIMTMSLMEQKSRGIQAVLVGLKNMEVHLYRDKNLLSVINTPDIVTGLCFGRYGREDDTLIMTTQGGGLLIKILKRTAQFEDKDTAPGPPTGQSIKLNVPKKTKLYVDQTLRERENAVAMHRVFQMDLYRLRLSAARAYVKALDASLAPVSSTMQEPLTLNAAVQGIGPQFKLILNLQNTSVNRPSMQLLISFLYDEKLYKIKPAFFKVPLLVPGLNYPIETFVECCSDKGISDIIKVFVLREGKSTPLLTAHINMPVSEGLAAA 585          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Xenopus
Match: ccdc84 (coiled-coil domain containing 84 [Source:Xenbase;Acc:XB-GENE-923273])

HSP 1 Score: 560.451 bits (1443), Expect = 0.000e+0
Identity = 269/574 (46.86%), Postives = 400/574 (69.69%), Query Frame = 3
Query:   99 WLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            WL AH + +A L ++S C+ L D++GDG+  +VV D+         MKLKVY+G +   E  ++DLPTGV +F +D+NEPRTP +AVASGP+IYVYKN++PYFKFTLP++ V   E+ +W +  ED ++   LKE L+ +R+ A + LSVRS+R LML  ++ME F N YK  PLK+QTV TC+ TLKK+ +++DA+ CLV+GTE+G+L ++DPEAFT+L  V+ +++P  +   G YD+E+RI VACRNGN+Y+++R     K  I+L+ Q + ++RV K +++G   +TL  +S KG+++W  TLPA++++M  ++    G+Q  +V L N  + +Y +++L+  I+  D VTGL FG++GRE   L+M T+ G L+IK+LKRTA F  + +  GPP  Q  KLN+PKKTKL++DQ  REREN+VA+HR F  DL +LR++ AR+YV+ L+    P+SS   +P+ L   V GIGP FK+ ++++N+S+   S  L I F+YD K+Y I  +  +VPLLVPG++YP   +VEC SDKGI+D IKV VL+  ++ P++T  +NMPVSE   A+
Sbjct:   18 WLDAHYDPVAGLNTLSSCIALADLHGDGDFKMVVGDMGHGPY---NMKLKVYKGTARMSENALLDLPTGVAAFLMDQNEPRTPAIAVASGPFIYVYKNLRPYFKFTLPAMEVNALEKEVWDQAKEDKIDPVTLKEMLESIRDKAEIPLSVRSLRFLMLELQEMEAFVNTYKQQPLKRQTVITCMGTLKKNMADEDAVCCLVIGTESGELFILDPEAFTILTRVSLSSVPTLLDVTGQYDIEYRITVACRNGNVYILRRDSKRPKYCIELSAQVVGLVRVQKNIMIGTSHETLHGYSQKGKRLWTVTLPASIMTMSLMEQKSRGIQAVLVGLKNMEVHLYRDKNLLSVINTPDIVTGLCFGRYGREDDTLIMTTQGGGLLIKILKRTAQFEDKDTAPGPPTGQSIKLNVPKKTKLYVDQTLRERENAVAMHRVFQMDLYRLRLSAARAYVKALDASLAPVSSTMQEPLTLNAAVQGIGPQFKLILNLQNTSVNRPSMQLLISFLYDEKLYKIKPAFFKVPLLVPGLNYPIETFVECCSDKGISDIIKVFVLREGKSTPLLTAHINMPVSEGLAAA 588          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Xenopus
Match: ccdc84 (coiled-coil domain containing 84 [Source:Xenbase;Acc:XB-GENE-923273])

HSP 1 Score: 546.584 bits (1407), Expect = 0.000e+0
Identity = 270/580 (46.55%), Postives = 398/580 (68.62%), Query Frame = 3
Query:   81 EEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            E +SK WL AH + +A L ++S C+ L D++GDG+  +VV D+         MKLKVY+G +   E  ++DLPTGV +F +D+NEPRTP +AVASGP+IYVYKN++PYFKFTLP++ V   E+ +W          +Q KE    +RN A + LSVRS+R LML  ++ME F N YK  PLK+QTV TC+ TLKK+ +++DA+ CLV+GTE+G+L ++DPEAFT+L  V+ +++P  +   G YD+E+RI VACRNGN+Y+++R     K  I+L+ Q + ++RV K +++G   +TL  +S KG+++W  TLPA++++M  ++    G+Q  +V L N  + +Y +++L+  I+  D VTGL FG++GRE   L+M T+ G L+IK+LKRTA F  + +  GPP  Q  KLN+PKKTKL++DQ  REREN+VA+HR F  DL +LR++ AR+YV+ L+    P+SS   +P+ L   V GIGP FK+ ++++N+S+   S  L I F+YD K+Y I  +  +VPLLVPG++YP   +VEC SDKGI+D IKV VL+  ++ P++T  +NMPVSE   A+
Sbjct:   12 ESRSK-WLDAHYDPVAGLNTLSSCIALADLHGDGDFKMVVGDMGHGPY---NMKLKVYKGTARMSENALLDLPTGVAAFLMDQNEPRTPAIAVASGPFIYVYKNLRPYFKFTLPAMEVNALEKEVW----------DQAKE----VRNKAEIPLSVRSLRFLMLELQEMEAFVNTYKQQPLKRQTVITCMGTLKKNMADEDAVCCLVIGTESGELFILDPEAFTILTRVSLSSVPTLLDVTGQYDIEYRITVACRNGNVYILRRDSKRPKYCIELSAQVVGLVRVQKNIMIGTSHETLHGYSQKGKRLWTVTLPASIMTMSLMEQKSRGIQAVLVGLKNMEVHLYRDKNLLSVINTPDIVTGLCFGRYGREDDTLIMTTQGGGLLIKILKRTAQFEDKDTAPGPPTGQSIKLNVPKKTKLYVDQTLRERENAVAMHRVFQMDLYRLRLSAARAYVKALDASLAPVSSTMQEPLTLNAAVQGIGPQFKLILNLQNTSVNRPSMQLLISFLYDEKLYKIKPAFFKVPLLVPGLNYPIETFVECCSDKGISDIIKVFVLREGKSTPLLTAHINMPVSEGLAAA 573          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Xenopus
Match: ccdc84 (coiled-coil domain containing 84 [Source:Xenbase;Acc:XB-GENE-923273])

HSP 1 Score: 545.043 bits (1403), Expect = 0.000e+0
Identity = 267/574 (46.52%), Postives = 394/574 (68.64%), Query Frame = 3
Query:   99 WLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            WL AH + +A L ++S C+ L D++GDG+  +VV D+         MKLKVY+G +   E  ++DLPTGV +F +D+NEPRTP +AVASGP+IYVYKN++PYFKFTLP++ V   E+ +W          +Q KE    +RN A + LSVRS+R LML  ++ME F N YK  PLK+QTV TC+ TLKK+ +++DA+ CLV+GTE+G+L ++DPEAFT+L  V+ +++P  +   G YD+E+RI VACRNGN+Y+++R     K  I+L+ Q + ++RV K +++G   +TL  +S KG+++W  TLPA++++M  ++    G+Q  +V L N  + +Y +++L+  I+  D VTGL FG++GRE   L+M T+ G L+IK+LKRTA F  + +  GPP  Q  KLN+PKKTKL++DQ  REREN+VA+HR F  DL +LR++ AR+YV+ L+    P+SS   +P+ L   V GIGP FK+ ++++N+S+   S  L I F+YD K+Y I  +  +VPLLVPG++YP   +VEC SDKGI+D IKV VL+  ++ P++T  +NMPVSE   A+
Sbjct:   18 WLDAHYDPVAGLNTLSSCIALADLHGDGDFKMVVGDMGHGPY---NMKLKVYKGTARMSENALLDLPTGVAAFLMDQNEPRTPAIAVASGPFIYVYKNLRPYFKFTLPAMEVNALEKEVW----------DQAKE----VRNKAEIPLSVRSLRFLMLELQEMEAFVNTYKQQPLKRQTVITCMGTLKKNMADEDAVCCLVIGTESGELFILDPEAFTILTRVSLSSVPTLLDVTGQYDIEYRITVACRNGNVYILRRDSKRPKYCIELSAQVVGLVRVQKNIMIGTSHETLHGYSQKGKRLWTVTLPASIMTMSLMEQKSRGIQAVLVGLKNMEVHLYRDKNLLSVINTPDIVTGLCFGRYGREDDTLIMTTQGGGLLIKILKRTAQFEDKDTAPGPPTGQSIKLNVPKKTKLYVDQTLRERENAVAMHRVFQMDLYRLRLSAARAYVKALDASLAPVSSTMQEPLTLNAAVQGIGPQFKLILNLQNTSVNRPSMQLLISFLYDEKLYKIKPAFFKVPLLVPGLNYPIETFVECCSDKGISDIIKVFVLREGKSTPLLTAHINMPVSEGLAAA 574          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Xenopus
Match: ccdc84 (coiled-coil domain containing 84 [Source:Xenbase;Acc:XB-GENE-923273])

HSP 1 Score: 531.561 bits (1368), Expect = 0.000e+0
Identity = 261/579 (45.08%), Postives = 389/579 (67.18%), Query Frame = 3
Query:   81 EEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            E +SK WL AH + +A L ++S C+ L D++GDG+  +VV D+         MKLKVY+G +   E  ++DLPTGV +F +D+NEPRTP +AVASGP+IYVYKN++PYFKFTLP++ V   E+ +W +  E       L  +        +   +   R LML  ++ME F N YK  PLK+QTV TC+ TLKK+ +++DA+ CLV+GTE+G+L ++DPEAFT+L  V+ +++P  +   G YD+E+RI VACRNGN+Y+++R     K  I+L+ Q + ++RV K +++G   +TL  +S KG+++W  TLPA++++M  ++    G+Q  +V L N  + +Y +++L+  I+  D VTGL FG++GRE   L+M T+ G L+IK+LKRTA F  + +  GPP  Q  KLN+PKKTKL++DQ  REREN+VA+HR F  DL +LR++ AR+YV+ L+    P+SS   +P+ L   V GIGP FK+ ++++N+S+   S  L I F+YD K+Y I  +  +VPLLVPG++YP   +VEC SDKGI+D IKV VL+  ++ P++T  +NMPVSE   A+
Sbjct:   17 ESRSK-WLDAHYDPVAGLNTLSSCIALADLHGDGDFKMVVGDMGHGPY---NMKLKVYKGTARMSENALLDLPTGVAAFLMDQNEPRTPAIAVASGPFIYVYKNLRPYFKFTLPAMEVNALEKEVWDQAKEVRTWPHSLFINYIKFCILPVIFILHFSRFLMLELQEMEAFVNTYKQQPLKRQTVITCMGTLKKNMADEDAVCCLVIGTESGELFILDPEAFTILTRVSLSSVPTLLDVTGQYDIEYRITVACRNGNVYILRRDSKRPKYCIELSAQVVGLVRVQKNIMIGTSHETLHGYSQKGKRLWTVTLPASIMTMSLMEQKSRGIQAVLVGLKNMEVHLYRDKNLLSVINTPDIVTGLCFGRYGREDDTLIMTTQGGGLLIKILKRTAQFEDKDTAPGPPTGQSIKLNVPKKTKLYVDQTLRERENAVAMHRVFQMDLYRLRLSAARAYVKALDASLAPVSSTMQEPLTLNAAVQGIGPQFKLILNLQNTSVNRPSMQLLISFLYDEKLYKIKPAFFKVPLLVPGLNYPIETFVECCSDKGISDIIKVFVLREGKSTPLLTAHINMPVSEGLAAA 591          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Mouse
Match: Bbs1 (Bardet-Biedl syndrome 1 (human) [Source:MGI Symbol;Acc:MGI:1277215])

HSP 1 Score: 520.39 bits (1339), Expect = 1.219e-178
Identity = 256/582 (43.99%), Postives = 388/582 (66.67%), Query Frame = 3
Query:   75 DKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLR-NAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            +  E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G ++  E+ +  LP    +F +D++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  ED ++   LKE L+ +R  A + LSV+S+R L L   +ME F N +KS  +K+QTV T +TTLKK+ +++DA SCLV+GTE+ +LLV+DPEAFT+L  ++  ++PVF+   G +DVEFR+  ACRNG+IY+++R     K  I+L+ QP+ ++RV+K L+VG   ++L  F+ KG+++W   +PA +++M  L+    G+Q  + +L N  + IY ++ L++ I   D VT L FG++GRE   L+M TR G LIIK+LKRTA F   T   GPP AQ  KL++P+KT+L++DQ  RERE   A+HR F  DL  LR+  AR+YV+ LE+  +P+S+   +P+ L   V G+GPTFK+ + ++N+S       L + F+Y+  +YA+  +  +VPLLVPG+SYP   +VE +S KGI+D IKVLVL+  ++ P+++  +NMPVSE   A+
Sbjct:   15 ESNEANSKWLDAHYDPMANIHTFSSCLSLADLHGDGEYKLVVGDL---GPGGQQPRLKVLKGPTVLTESPLPALPASAATFLMDQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDVWNQAKEDQIDPLTLKEMLEDIREKADVPLSVQSLRFLQLELSEMEAFVNQHKSKVIKRQTVITTMTTLKKNLADEDAASCLVLGTESKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLTAACRNGSIYILRRDSKHPKYCIELSAQPVGLVRVHKVLVVGSTQESLHGFTHKGKKLWTVQMPAAILTMNLLEQRSRGLQAVMAALANGEVRIYRDKALLNVIHAPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGTGEVGPPLAQTTKLSVPRKTRLYVDQTLREREAGTAMHRTFQTDLYLLRLRAARAYVQALESSLSPMSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTARPVLGLHVCFLYNKALYALPQAFFKVPLLVPGLSYPLETFVESLSSKGISDMIKVLVLREGQSAPLLSAHINMPVSEGLAAA 593          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Mouse
Match: Bbs1 (Bardet-Biedl syndrome 1 (human) [Source:MGI Symbol;Acc:MGI:1277215])

HSP 1 Score: 308.531 bits (789), Expect = 1.581e-97
Identity = 150/352 (42.61%), Postives = 232/352 (65.91%), Query Frame = 3
Query:  762 VTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            ++  ++PVF+   G +DVEFR+  ACRNG+IY+++R     K  I+L+ QP+ ++RV+K L+VG   ++L  F+ KG+++W   +PA +++M  L+    G+Q  + +L N  + IY ++ L++ I   D VT L FG++GRE   L+M TR G LIIK+LKRTA F   T   GPP AQ  KL++P+KT+L++DQ  RERE   A+HR F  DL  LR+  AR+YV+ LE+  +P+S+   +P+ L   V G+GPTFK+ + ++N+S       L + F+Y+  +YA+  +  +VPLLVPG+SYP   +VE +S KGI+D IKVLVL+  ++ P+++  +NMPVSE   A+
Sbjct:  145 MSLPSVPVFLEVSGQFDVEFRLTAACRNGSIYILRRDSKHPKYCIELSAQPVGLVRVHKVLVVGSTQESLHGFTHKGKKLWTVQMPAAILTMNLLEQRSRGLQAVMAALANGEVRIYRDKALLNVIHAPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGTGEVGPPLAQTTKLSVPRKTRLYVDQTLREREAGTAMHRTFQTDLYLLRLRAARAYVQALESSLSPMSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTARPVLGLHVCFLYNKALYALPQAFFKVPLLVPGLSYPLETFVESLSSKGISDMIKVLVLREGQSAPLLSAHINMPVSEGLAAA 496          

HSP 2 Score: 130.183 bits (326), Expect = 9.162e-32
Identity = 58/136 (42.65%), Postives = 88/136 (64.71%), Query Frame = 3
Query:   75 DKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSV 482
            +  E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G ++  E+ +  LP    +F +D++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  E S+
Sbjct:   15 ESNEANSKWLDAHYDPMANIHTFSSCLSLADLHGDGEYKLVVGDL---GPGGQQPRLKVLKGPTVLTESPLPALPASAATFLMDQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDVWNQAKEMSL 147          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Mouse
Match: Bbs1 (Bardet-Biedl syndrome 1 (human) [Source:MGI Symbol;Acc:MGI:1277215])

HSP 1 Score: 216.853 bits (551), Expect = 2.889e-63
Identity = 106/228 (46.49%), Postives = 156/228 (68.42%), Query Frame = 3
Query:   75 DKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLR-NAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVL 755
            +  E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G ++  E+ +  LP    +F +D++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  ED ++   LKE L+ +R  A + LSV+S+R L L   +ME F N +KS  +K+QTV T +TTLKK+ +++DA SCLV+GTE+ +LLV+DPEAFT+L
Sbjct:   15 ESNEANSKWLDAHYDPMANIHTFSSCLSLADLHGDGEYKLVVGDL---GPGGQQPRLKVLKGPTVLTESPLPALPASAATFLMDQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDVWNQAKEDQIDPLTLKEMLEDIREKADVPLSVQSLRFLQLELSEMEAFVNQHKSKVIKRQTVITTMTTLKKNLADEDAASCLVLGTESKELLVLDPEAFTIL 239          

HSP 2 Score: 178.333 bits (451), Expect = 5.305e-49
Identity = 97/210 (46.19%), Postives = 135/210 (64.29%), Query Frame = 3
Query: 1137 ISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDP 1766
            I   D VT L FG++GRE   L+M TR G LIIK+LKRTA F   T   GPP AQ  KL++P+KT+L++DQ  RERE   A+HR F  DL  LR+  AR+YV+ LE+  +P+S+   +P+ L   V G+GPTFK+ + ++N+S       L + F+Y+  +YA+  +  +VPLLVPG+SYP   +VE +S KGI+D IKV      + DP
Sbjct:  238 ILAKDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGTGEVGPPLAQTTKLSVPRKTRLYVDQTLREREAGTAMHRTFQTDLYLLRLRAARAYVQALESSLSPMSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTARPVLGLHVCFLYNKALYALPQAFFKVPLLVPGLSYPLETFVESLSSKGISDMIKVGGYFRGKWDP 447          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Mouse
Match: Bbs1 (Bardet-Biedl syndrome 1 (human) [Source:MGI Symbol;Acc:MGI:1277215])

HSP 1 Score: 127.102 bits (318), Expect = 1.185e-33
Identity = 57/133 (42.86%), Postives = 86/133 (64.66%), Query Frame = 3
Query:   75 DKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSE 473
            +  E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G ++  E+ +  LP    +F +D++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  E
Sbjct:   15 ESNEANSKWLDAHYDPMANIHTFSSCLSLADLHGDGEYKLVVGDLG---PGGQQPRLKVLKGPTVLTESPLPALPASAATFLMDQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDVWNQAKE 144          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. UniProt
Match: sp|Q3V3N7|BBS1_MOUSE (Bardet-Biedl syndrome 1 protein homolog OS=Mus musculus OX=10090 GN=Bbs1 PE=1 SV=1)

HSP 1 Score: 520.39 bits (1339), Expect = 8.526e-178
Identity = 256/582 (43.99%), Postives = 388/582 (66.67%), Query Frame = 3
Query:   75 DKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLR-NAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            +  E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G ++  E+ +  LP    +F +D++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  ED ++   LKE L+ +R  A + LSV+S+R L L   +ME F N +KS  +K+QTV T +TTLKK+ +++DA SCLV+GTE+ +LLV+DPEAFT+L  ++  ++PVF+   G +DVEFR+  ACRNG+IY+++R     K  I+L+ QP+ ++RV+K L+VG   ++L  F+ KG+++W   +PA +++M  L+    G+Q  + +L N  + IY ++ L++ I   D VT L FG++GRE   L+M TR G LIIK+LKRTA F   T   GPP AQ  KL++P+KT+L++DQ  RERE   A+HR F  DL  LR+  AR+YV+ LE+  +P+S+   +P+ L   V G+GPTFK+ + ++N+S       L + F+Y+  +YA+  +  +VPLLVPG+SYP   +VE +S KGI+D IKVLVL+  ++ P+++  +NMPVSE   A+
Sbjct:   15 ESNEANSKWLDAHYDPMANIHTFSSCLSLADLHGDGEYKLVVGDL---GPGGQQPRLKVLKGPTVLTESPLPALPASAATFLMDQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDVWNQAKEDQIDPLTLKEMLEDIREKADVPLSVQSLRFLQLELSEMEAFVNQHKSKVIKRQTVITTMTTLKKNLADEDAASCLVLGTESKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLTAACRNGSIYILRRDSKHPKYCIELSAQPVGLVRVHKVLVVGSTQESLHGFTHKGKKLWTVQMPAAILTMNLLEQRSRGLQAVMAALANGEVRIYRDKALLNVIHAPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGTGEVGPPLAQTTKLSVPRKTRLYVDQTLREREAGTAMHRTFQTDLYLLRLRAARAYVQALESSLSPMSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTARPVLGLHVCFLYNKALYALPQAFFKVPLLVPGLSYPLETFVESLSSKGISDMIKVLVLREGQSAPLLSAHINMPVSEGLAAA 593          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. UniProt
Match: sp|Q8NFJ9|BBS1_HUMAN (Bardet-Biedl syndrome 1 protein OS=Homo sapiens OX=9606 GN=BBS1 PE=1 SV=1)

HSP 1 Score: 508.064 bits (1307), Expect = 6.577e-173
Identity = 254/582 (43.64%), Postives = 385/582 (66.15%), Query Frame = 3
Query:   75 DKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            +  E +  WL AH + +A++ + S C+ L D++GDGE  LVV DL        Q +LKV +G  +  E+ +  LP    +F ++++EPRTP LA+ASGP +YVYKN++PYFKF+LP LP    E+++W +  ED ++   LKE L+ +R  A   LS++S+R L L   +ME F N +KS  +K+QTV T +TTLKK+ +++DA+SCLV+GTE  +LLV+DPEAFT+L  ++  ++PVF+   G +DVEFR+  ACRNGNIY+++R     K  I+L+ QP+ ++RV+K L+VG   D+L  F+ KG+++W   +PA +++M  L+    G+Q  +  L N  + IY ++ L++ I   D VT L FG++GRE   L+M TR G LIIK+LKRTA F    S  GPP AQ  KLN+P+KT+L++DQ  RERE   A+HR F  DL  LR+  AR+Y++ LE+  +P+S+   +P+ L   V G+GPTFK+ + ++N+S       L + F+Y+  +Y++  +  +VPLLVPG++YP   +VE +S+KGI+D IKVLVL+  ++ P+++  VNMP SE   A+
Sbjct:   15 ESNEANSKWLDAHYDPMANIHTFSACLALADLHGDGEYKLVVGDL---GPGGQQPRLKVLKGPLVMTESPLPALPAAAATFLMEQHEPRTPALALASGPCVYVYKNLRPYFKFSLPQLPPNPLEQDLWNQAKEDRIDPLTLKEMLESIRETAEEPLSIQSLRFLQLELSEMEAFVNQHKSNSIKRQTVITTMTTLKKNLADEDAVSCLVLGTENKELLVLDPEAFTILAKMSLPSVPVFLEVSGQFDVEFRLAAACRNGNIYILRRDSKHPKYCIELSAQPVGLIRVHKVLVVGSTQDSLHGFTHKGKKLWTVQMPAAILTMNLLEQHSRGLQAVMAGLANGEVRIYRDKALLNVIHTPDAVTSLCFGRYGREDNTLIMTTRGGGLIIKILKRTAVFVEGGSEVGPPPAQAMKLNVPRKTRLYVDQTLREREAGTAMHRAFQTDLYLLRLRAARAYLQALESSLSPLSTTAREPLKLHAVVQGLGPTFKLTLHLQNTSTTRPVLGLLVCFLYNEALYSLPRAFFKVPLLVPGLNYPLETFVESLSNKGISDIIKVLVLREGQSAPLLSAHVNMPGSEGLAAA 593          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. UniProt
Match: sp|Q9NEZ7|BBS1_CAEEL (Bardet-Biedl syndrome 1 protein homolog OS=Caenorhabditis elegans OX=6239 GN=bbs-1 PE=1 SV=1)

HSP 1 Score: 259.61 bits (662), Expect = 4.291e-77
Identity = 165/561 (29.41%), Postives = 295/561 (52.58%), Query Frame = 3
Query:  129 DLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN--AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIAD-TIKVLVLKNNETDPIVTGVVNMPVSE 1802
            +++  S C+    I  D ++ L++A    H+     MKLKV++ +    E+++ D+PT +V F  D +    P +AVA+GP + +YKN+KP++KFT+PS  +   E   WK      +N + L   L  L +  A   L+  S   L    E        Y +      T+ TC+  L KS +E   +  LV+GTE  ++ +ID +AFT+L  +   ++PV +C  G YDV++R++V  R   I+ +KRG+   + ++   +   SM+ VNK ++   +++ +   S +G++M     P+  I M +           ++++ +  I +YN   L+D +     +  + +G +GRE   L++  + GS+ I++ +R A+F T+      PQA   KL IPKKTK+F+D   RE +    IH+ + ++L  ++   A SY+E+  +    +S+    P+ +++++HG GPTF+M + + +SS Q    D+ +  + D ++Y  D  +I V LL  G SY ++  + C   +  A+  ++ L++      PIVT V+ MP SE
Sbjct:   22 EIYCPSTCVAFGPILSDNDSKLIIAH-GGHRG--VNMKLKVFQQLEQLSESSLADMPTALVHFINDLSS--IPSIAVAAGPSLLIYKNLKPFYKFTVPSSAINPTESEAWKAVVNKKINGDTLLTVLKRLEDDVAFSKLTPISQTYLRADKETQVVLVEHYGTKIANSATI-TCIAKLTKSTAE--PLDILVIGTEHCEIFLIDSQAFTILETIKIGSVPVNICAYGTYDVDYRLFVQTRASLIFCMKRGEADYQPIVISQSMITSMVLVNKMIVYTTVENLIHFASFRGKKMNTVKCPSK-IKMLEPFIYPLKQLAAVIAVFDKEIRMYNEHYLLDTVQYEKPLAWVKYGCYGREDSTLVVAFKDGSIAIQIFRRKANFDTKLDYNQVPQAHALKLQIPKKTKVFIDLTQREVQLGNRIHKVYQKNLFDVKYRLAASYLELTSSASATVSTTTVLPVEISVDIHGFGPTFRMTIHLLSSSKQNL-YDMHLSIISDPELYDFDTPLIPVHLLASGQSYSFTTLLYCKDPEKAANCDVRALLVHAKRATPIVTAVIKMPFSE 572          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. TrEMBL
Match: gnl|BL_ORD_ID|20333607 (tr|A0A1S3I1L6|A0A1S3I1L6_LINUN Bardet-Biedl syndrome 1 protein homolog OS=Lingula unguis OX=7574 GN=LOC106159841 PE=4 SV=1)

HSP 1 Score: 626.706 bits (1615), Expect = 0.000e+0
Identity = 298/591 (50.42%), Postives = 427/591 (72.25%), Query Frame = 3
Query:   39 MDKQSEKPTESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFI 1811
            M  QS    +S D       WL+A  + +A L++ SQC+ L DIN DG+N L++ADL    +   QMKLKVY+G +L  E  +IDLPTGV +F++D+NEPRTP +AVASGPY+YVYKN++PYFKFTLPSL +   E+++W +  ++ ++   L+E L+G+R  G +L+VRS+R + L  E +E F N YK  PLKKQTV T L T+KKS +E+DAISCLV+GTE+ Q+ ++DPEAFTVL  +   ++PVF+   GLYDVEFRI VACRNGNIY++KRG   A+S I+LN+QP+ + R+ K ++VGCMD+TL+C++ KG+++W   LPA++ SM  +D    G +  +V+L N  + IY ++ L++ I   D VTG+ FG+FGRE  +L+M T+ G LI+K+LKRTA F  + +  GPP +Q  KLN+PKKTKLF+DQ  RERE+ V++HR F  DL +LR+  ARSYV+ LET  NP+S+  ++P+ L+ +V GIGPTFK+ V+++N+S+ TAS +L I F +D ++Y I  + I VP+LVPG+SY +  +V+C+SDKGI+DTIKV VL+   + PI+T +++MPVSET +
Sbjct:    1 MTSQSTTSKDSIDATRDDGKWLSAFYDPVASLYTFSQCITLSDINADGDNKLIIADL---GTGSYQMKLKVYKGTNLVSENTLIDLPTGVATFYMDQNEPRTPAVAVASGPYMYVYKNLRPYFKFTLPSLEINPLEQDVWNQVRDERIDVGVLREMLEGMRAEGTSLTVRSLRFIQLQAEDLEAFANQYKHTPLKKQTVITSLGTMKKSLAEEDAISCLVLGTESKQVYILDPEAFTVLSTMNLPSVPVFLNVSGLYDVEFRIIVACRNGNIYMLKRGTKNARSCIELNSQPVGLERMGKNIVVGCMDETLQCYTTKGKKLWTIKLPASITSMENVDHKSKGFKAVMVALSNCEVHIYKDKYLVNIIKTEDIVTGMKFGRFGREDASLIMTTKGGGLIVKILKRTAVFEEKDATAGPPVSQNIKLNVPKKTKLFVDQTMREREHCVSMHRMFQHDLYRLRLDAARSYVKALETSMNPVSTNTTEPLKLSAQVQGIGPTFKLTVNLQNTSISTASFNLLITFQFDDRLYNIHKTYIPVPMLVPGLSYAFETFVDCLSDKGISDTIKVFVLRQGRSVPIITAMISMPVSETMV 588          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. TrEMBL
Match: gnl|BL_ORD_ID|15742050 (tr|R7U8T1|R7U8T1_CAPTE BBS1 domain-containing protein (Fragment) OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_108485 PE=4 SV=1)

HSP 1 Score: 616.69 bits (1589), Expect = 0.000e+0
Identity = 284/571 (49.74%), Postives = 412/571 (72.15%), Query Frame = 3
Query:   99 WLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFI 1811
            WL AH + ++ L++ +QC+ + DIN DG++ L++ADL    +    MKLKVY+G SL  E  IIDLPTGVV+F++D NEP TP +AVASGP+IYVYKN++PYFKFTLP+L V   E+++W +  ED ++   L+E LDGLR  G TL+VRS+R L L +  +E F +++K  PLK+QTV TCL T+KKS +E+DAISCL++GTE+  + V+DPEAFTVL  +   ++PVFM   GL+DVEFRI VACRNG IY  KRG    K++ +LN+QP+ + R+ K +IVGCMD TL+C++ KG+++W   +PA + ++  +D  Q G +  +V+L N  + IY ++ L + +   D +TG+ FG+FGRE+ +L+M T+ G L+I++LKRTA F  +  + GPP +Q +KLN+PKKTKLF+DQ  REREN+V++HR+F  DL +LR+ TAR+YV+ L+   NPIS+   +P+ LA +V G+GP FK+ V+++N+S+   S DL I F YD  +Y  + S+IQ P+LVPG++Y +   VEC+SDKGI+DT+KV VLK N + PI+  ++NMP+SE  +
Sbjct:    4 WLEAHYDPVSSLYTFTQCITMSDINADGDHKLIIADL---GTGSYDMKLKVYKGTSLMTENAIIDLPTGVVTFYMDTNEPHTPAIAVASGPFIYVYKNLRPYFKFTLPTLSVNPVEQDLWDQVKEDRIDVMSLREMLDGLRCEGATLTVRSMRFLQLQSHDLEPFASLHKHAPLKRQTVITCLATMKKSMAEEDAISCLILGTESSHIYVLDPEAFTVLATMDLPSVPVFMSVSGLFDVEFRIVVACRNGGIYNFKRGVKEGKTVFELNSQPVGLERLGKNIIVGCMDRTLQCYTSKGKKLWSVAVPADITTIQMMDHQQKGFKAILVALANSEVHIYRDKYLCNVMKTPDVITGMKFGRFGREEASLIMTTKGGGLVIRILKRTAKFEEKDISAGPPSSQNQKLNVPKKTKLFVDQTMRERENAVSMHRQFQHDLYRLRLETARNYVKALDRSMNPISTNPQEPLKLAAQVQGLGPIFKLTVNLQNTSMTVPSLDLIITFQYDNTLYKFNKSIIQTPMLVPGLNYSFEALVECLSDKGISDTVKVFVLKKNRSVPIIAAIINMPISEAMV 571          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. TrEMBL
Match: gnl|BL_ORD_ID|17757318 (tr|A0A2G8JHK9|A0A2G8JHK9_STIJA Uncharacterized protein (Fragment) OS=Stichopus japonicus OX=307972 GN=BSL78_27943 PE=4 SV=1)

HSP 1 Score: 598.586 bits (1542), Expect = 0.000e+0
Identity = 291/573 (50.79%), Postives = 407/573 (71.03%), Query Frame = 3
Query:   90 SKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGM--TLSVRSIRLLMLSN-EKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVS 1799
            S  WL+AH + +A L++ S CM L DI GDGEN LV+ADL    +    MKLKVY+G SL  E  IIDLPTGV +F++D  EPR P +AVASGPY+YVYKN++PYFKFTLP L V   E+++W +  +D ++   L+E LD +R  G    L+VRS+R LML + ++ME F   YK   LKK TV TCL+TLKKS ++DDAISCLVVGTE+ ++ ++DPEAFT+L  +T  + PVF+   GL+DVE+R+ V+CRNGNIY +K+G  + +  ++L++QP+ + RV K +IVGCMD TL+C++ KG+ +W   L  ++I+M  +D  Q G +  +V+L N  +++Y ++ LID I     +TG+LFG+FGRE  +L+M TR G L IK+LKR A F  +   +GPP AQ +KLN+PKKTK+F+DQ  REREN VA+HR F  DL +LR+ TAR YV++L +  NPIS+  S+P+ LA +V GIGPTFKM V+++N+SL     +  I F+YD K+Y++  ++I VPLLVPG++Y +   VE ISDKG++D IKV V+K + T P++T V+NMPVS
Sbjct:   27 STKWLSAHFDPVASLYTFSSCMTLSDITGDGENRLVIADL---GTGAHNMKLKVYKGTSLVNENTIIDLPTGVATFYMDIIEPRVPAVAVASGPYLYVYKNLRPYFKFTLPPLEVNPVEQDLWNQVRDDKIDVTVLREMLDSIRREGTEGALTVRSLRFLMLPDKDQMELFAQAYKHTALKKLTVITCLSTLKKSSADDDAISCLVVGTESKEIYILDPEAFTILAKMTLPSQPVFLKITGLFDVEYRMVVSCRNGNIYTLKKGMKIGRLCVELSSQPVGLERVGKNIIVGCMDQTLQCYTIKGKMLWTVYLSDSIITMSVMDHRQKGFKAIMVALNNGDVQVYRDKYLIDTIKTDSAITGILFGRFGREDSSLIMTTRRGGLSIKILKRNAVFEDKDLARGPPAAQNQKLNVPKKTKVFVDQTMRERENGVAMHRMFQHDLYRLRLNTAREYVKVLNSSMNPISTNLSEPLKLAAQVQGIGPTFKMTVNVQNTSLAVPIMNTLISFLYDEKLYSLQKTMIPVPLLVPGLNYKFETLVESISDKGLSDVIKVFVVKESSTAPVITAVINMPVS 596          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. TrEMBL
Match: gnl|BL_ORD_ID|17232999 (tr|A0A433SWB5|A0A433SWB5_ELYCH BBS1 domain-containing protein OS=Elysia chlorotica OX=188477 GN=EGW08_018639 PE=4 SV=1)

HSP 1 Score: 593.578 bits (1529), Expect = 0.000e+0
Identity = 286/578 (49.48%), Postives = 405/578 (70.07%), Query Frame = 3
Query:   81 EEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDT-VAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFI 1811
            E K+  WL A+ + +A +++ +QC+ L DI  DG+  L+VADL    +    MKLKVY+  +L  E  IIDLPTGVV+F++D  EPRTP +AVASGPYIYVYKN++PYFKFTLP L +   EE++W +  +D VN   ++E L+ LR  G +L+VRS+RLL L    +E F N++K  PLKKQTV TCL T+KKS +++DAISCLV+GTE+  + ++DPEAFTVL  +   ++PVF+   G++DV++RI V+CRNG +Y +KRG   V+K +I+LN+QP+ M R+NK + VGCMD+TL CF+ KG+++W   LPA++ ++  +D         +V+L N  + IY  + L+D I + D VTGL FG+FGRE   L+M T+ G L +K+LKRTA F  +    GPP AQ +KLN+PKKTKLF+DQ  REREN+V +HR F  DL QLR+   R YV+ L+   NPISS   +P+ L+  V GIGPTFK    ++N+SL  ASS+L I F YD+K+Y     +IQVP+LVPG++Y +  +V+C++DKG+ + +KV VLK  ++ P++TGVV+MPVSE+ +
Sbjct:    2 EGKNDKWLDAYHDPVASIYTFTQCLTLSDIQADGDWKLIVADL---GTGSYDMKLKVYKNTTLMSEHTIIDLPTGVVTFYMDTLEPRTPAIAVASGPYIYVYKNLRPYFKFTLPPLNIHPLEEDLWNQAKDDQVNVYSMREMLENLRQEGCSLTVRSLRLLQLEAGHVESFVNLHKHTPLKKQTVITCLDTMKKSVADEDAISCLVLGTESKSIYILDPEAFTVLATMDLPSVPVFISVNGMFDVDYRIVVSCRNGCVYTLKRGSKDVSKHMIELNSQPVGMQRINKNIYVGCMDETLHCFTSKGKKLWTVRLPASITTIEIIDYKPRSFAAVLVALSNQEVHIYKEKFLVDIIKMDDVVTGLQFGRFGREDGTLVMTTKRGGLFVKILKRTAKFEERALAAGPPVAQNQKLNVPKKTKLFVDQTQRERENAVVMHRTFQRDLAQLRLKVMREYVKALDNSMNPISSDPMEPLKLSAHVQGIGPTFKFTTKLQNTSLSQASSNLVITFDYDSKLYDFRKKMIQVPMLVPGLTYNFETFVDCLNDKGVTENVKVYVLKQGKSVPLITGVVSMPVSESIV 576          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. TrEMBL
Match: gnl|BL_ORD_ID|17507758 (tr|A7S5W5|A7S5W5_NEMVE Predicted protein OS=Nematostella vectensis OX=45351 GN=v1g186039 PE=4 SV=1)

HSP 1 Score: 585.874 bits (1509), Expect = 0.000e+0
Identity = 280/584 (47.95%), Postives = 411/584 (70.38%), Query Frame = 3
Query:   66 ESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGM--TLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFI 1811
            ES    ++   WL+AH + ++ L++ S  + L D+N DG+  L+VADL    +    MKLKVY+G +L  E+ IIDLPT +V+F++D N+PRTP +AVASGP+IYVYKN++PYFKFTLP L V   E+++W +  ED ++ + L+E L+ LR+ G   +L+VRS++ L L  E+ME+F +++K  PLK+QTV TC+ T+KKS +++DA+SCLV+GTE+  + ++DPEAFTVL  ++  ++P FM   GLYDVEFR+ VACR+G +Y +KRG+ +AK+ I+L  Q + + R+ K +IVGCMD+TL C+S KG+++W   LPA + +M  +D    G +G +V+L N  + +Y ++ L++ + + DTVT + FG+FGRE  AL+++TR G   +K+LKRTA F  +    GPP AQ  KLN+PKKTK+F+DQ  RERE++V++HR F  DL  LR+T ARSYV  L+   NP+SS   +P+ L+ ++ GIGP FK+ V+++N S   A ++L I F +D  +YA+    I VPLLVPG+SY Y   VECISDKGI+D IKV VL+  ++ PI+T V+NMPVSE  +
Sbjct:    2 ESTTSLKEDDVWLSAHHDPVSSLYTFSSSISLADLNADGDFKLLVADL---GTGTYDMKLKVYKGTNLFMESAIIDLPTALVAFYMDTNDPRTPAVAVASGPFIYVYKNLRPYFKFTLPPLEVNAVEQDLWNQAKEDRIDVQMLREMLESLRSEGSEGSLTVRSLKFLSLHPEEMEDFASLHKMAPLKRQTVITCMNTMKKSVADEDAVSCLVIGTESKDIYILDPEAFTVLSKMSLLSVPAFMSVSGLYDVEFRVIVACRDGKVYTLKRGNKIAKASIELTAQAVGLERIGKNIIVGCMDNTLVCYSTKGKKLWTVYLPANIATMALMDYKARGFKGVMVALTNGEVRLYKDKFLVNTLQMQDTVTAIRFGRFGREDSALILITRGGGFYVKILKRTATFDGKDLTPGPPLAQSVKLNVPKKTKVFVDQTLRERESAVSMHRMFQHDLYLLRLTAARSYVNALQKSLNPVSSSALEPLKLSAQIQGIGPAFKLTVNLQNISPSVAITNLLITFQHDESLYALAKPCIIVPLLVPGLSYSYETLVECISDKGISDAIKVFVLRQGKSVPIITAVINMPVSEALV 582          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Cavefish
Match: bbs1 (Bardet-Biedl syndrome 1 [Source:NCBI gene;Acc:103022421])

HSP 1 Score: 573.933 bits (1478), Expect = 0.000e+0
Identity = 270/585 (46.15%), Postives = 410/585 (70.09%), Query Frame = 3
Query:   51 SEKPTESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSE 1802
            S  P E  D    S  WL AH + +A+L++ S C+ L D++GDGEN LVV DL    +  + MKLKVYRG  L  E  ++DLPTG+VSF +D++EPRTP +AVASGP+IY+YKN++PYFKFTLP+L V   E+++W +  ED ++   LKE L+G+R+ A + LSVRS+R LML  + ME + N++K  P+++QTV TC+ TLKK+ +++DA+SCLV+GTE+ ++ ++DPEAFT+L  ++  ++P  M   G +DVEFRI +ACRNGNIY+++R     K  I+L++ P+ ++R+ K ++VGC  +TL  ++ KG+++W   LPA + +M  LD    G Q  +V+L +  + +Y +++L+  I   D VT + FG++GRE   L+M T+ G LI+K+LKRTA F  + S  GPP AQ  +LN+PKKTKL++DQ  REREN+VA+HR F  DL ++R+  AR+YV+ LE+   P+S+  ++P+ +   V G+GPTFK+ ++I+N++      +LAI F+YD  +Y++  +  ++PLLVPG++YP   +VEC+SDKGI+D IKV VL+  ++ P++T  +NMPVSE
Sbjct:    2 SSVPMEMKDGAVSSSKWLDAHYDPVANLYTFSSCIALADLHGDGENKLVVGDL---GTGASNMKLKVYRGTGLLSENTLLDLPTGLVSFLMDQHEPRTPAIAVASGPFIYIYKNLRPYFKFTLPTLEVNPLEQDVWSQAREDMIDPMTLKEMLEGIRDKAEIPLSVRSLRFLMLEPQDMEPYVNLHKQQPIRRQTVITCIGTLKKNMADEDAVSCLVIGTESQEVYILDPEAFTILSKMSLPSVPTLMDVTGQFDVEFRITIACRNGNIYILRRDSPKPKYCIELSSHPVGLVRMGKNVVVGCAQETLHGYTQKGKKLWTTYLPAPVTTMAVLDLPTRGFQAVLVALASCEVHVYRDKNLVSTIKTPDVVTSICFGRYGREDGTLIMTTKGGGLIVKILKRTAVFDERDSAPGPPIAQSIRLNVPKKTKLYVDQTMRERENAVAMHRAFQMDLSRMRLAAARAYVKALESSLTPMSASLTEPLKMNAVVQGLGPTFKLTLNIQNTAASRPVMNLAISFLYDENLYSMKTAFFKIPLLVPGLNYPIDTFVECLSDKGISDIIKVFVLREGKSAPLLTAHINMPVSE 583          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Cavefish
Match: bbs1 (Bardet-Biedl syndrome 1 [Source:NCBI gene;Acc:103022421])

HSP 1 Score: 518.464 bits (1334), Expect = 1.442e-178
Identity = 249/553 (45.03%), Postives = 377/553 (68.17%), Query Frame = 3
Query:  144 SQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSE 1802
            S C+ L D++GDGEN LVV DL    +  + MKLKVYRG  L  E  ++DLPTG+VSF +D++EPRTP +AVASGP+IY+YKN++PYFKFTLP+L V   E+++W +  E           L  L      L     R LML  + ME + N++K  P+++QTV TC+ TLKK+ +++DA+SCLV+GTE+ ++ ++DPEAFT+L  ++  ++P  M   G +DVEFRI +ACRNGNIY+++R     K  I+L++ P+ ++R+ K ++VGC  +TL  ++ KG+++W   LPA + +M  LD    G Q  +V+L +  + +Y +++L+  I   D VT + FG++GRE   L+M T+ G LI+K+LKRTA F  + S  GPP AQ  +LN+PKKTKL++DQ  REREN+VA+HR F  DL ++R+  AR+YV+ LE+   P+S+  ++P+ +   V G+GPTFK+ ++I+N++      +LAI F+YD  +Y++  +  ++PLLVPG++YP   +VEC+SDKGI+D IKV VL+  ++ P++T  +NMPVSE
Sbjct:    1 SSCIALADLHGDGENKLVVGDL---GTGASNMKLKVYRGTGLLSENTLLDLPTGLVSFLMDQHEPRTPAIAVASGPFIYIYKNLRPYFKFTLPTLEVNPLEQDVWSQAREVRKAIFSYIFSLTFL-----VLPYIIFRFLMLEPQDMEPYVNLHKQQPIRRQTVITCIGTLKKNMADEDAVSCLVIGTESQEVYILDPEAFTILSKMSLPSVPTLMDVTGQFDVEFRITIACRNGNIYILRRDSPKPKYCIELSSHPVGLVRMGKNVVVGCAQETLHGYTQKGKKLWTTYLPAPVTTMAVLDLPTRGFQAVLVALASCEVHVYRDKNLVSTIKTPDVVTSICFGRYGREDGTLIMTTKGGGLIVKILKRTAVFDERDSAPGPPIAQSIRLNVPKKTKLYVDQTMRERENAVAMHRAFQMDLSRMRLAAARAYVKALESSLTPMSASLTEPLKMNAVVQGLGPTFKLTLNIQNTAASRPVMNLAISFLYDENLYSMKTAFFKIPLLVPGLNYPIDTFVECLSDKGISDIIKVFVLREGKSAPLLTAHINMPVSE 545          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Sea Lamprey
Match: bbs1 (Bardet-Biedl syndrome 1 [Source:ZFIN;Acc:ZDB-GENE-060126-1])

HSP 1 Score: 547.74 bits (1410), Expect = 0.000e+0
Identity = 263/575 (45.74%), Postives = 405/575 (70.43%), Query Frame = 3
Query:   84 EKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAG-MTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTV-AKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSE 1802
            E +  WL AH + +A+L++ + CM L D++GDG+N LVVADL    +    MKL+V+RG +   E  +IDLPTGV +FF+D NEPR+P +AVASGP++YVYKN++PYFKFTLP L V + E ++W +  ED ++   LKE L+ +R+ G + L+VRS++ LM+  ++M  F  ++K  PLK+QTV TCL+TL+KS +++DA+SCLVVGTE+  + V+DPEAFT+L  ++  ++PVF+   GL+DVEFR+ VACRNGN+Y +KR D+   +  I+L++QP+ ++RVNK ++VGCMD++L+ ++ KG+++W   LPA + +M  +D    G +  +V++ N  + IY ++ L++ I   D VT + FG++GRE   L+M T+ G L IK+LKRTA F  + +  GPP AQ  KLN+PKKTKL++DQ  RERE +V++HR F  DL +LR+  AR+Y++ L++   P+SS  ++P+ L   V GIGP FK+ ++++N+S       L + F+YD ++Y++  +  ++P+LVPG++YP   +VEC SD+GI+D IKV  ++   + PI+T  +NMPVSE
Sbjct:   18 EGNPKWLDAHYDPVANLYTFTSCMALADLHGDGDNKLVVADL---GTGAYSMKLRVFRGTAPLVENTLIDLPTGVATFFMDTNEPRSPAIAVASGPFVYVYKNLRPYFKFTLPPLEVNQLEMDLWIQAREDKIDYMALKEMLENIRSKGDVPLTVRSLKFLMVEPQEMAAFAAVHKHTPLKRQTVITCLSTLRKSLADEDAVSCLVVGTESSDIFVLDPEAFTILAKMSLPSVPVFVDISGLFDVEFRVVVACRNGNVYTLKRRDSKKPRHCIELSSQPVGLVRVNKNVVVGCMDESLQGYTQKGKKLWTVNLPAAITTMQLMDHKGRGFKAVLVAMVNSEVHIYRDKYLVNIIKTQDVVTSVCFGRYGREDSTLVMTTKGGGLAIKILKRTAVFEEKDATLGPPVAQNIKLNVPKKTKLYVDQTLRERECAVSMHRVFQTDLYRLRLEAARAYMKALDSCLAPVSSSLAEPLKLNATVQGIGPNFKLTLNLQNTSPSRPCVGLFVCFLYDERLYSMTQAFFKLPMLVPGLNYPIETFVECRSDQGISDIIKVFAVREGSSIPILTAHINMPVSE 589          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Nematostella
Match: EDO40876 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5W5])

HSP 1 Score: 585.874 bits (1509), Expect = 0.000e+0
Identity = 280/584 (47.95%), Postives = 411/584 (70.38%), Query Frame = 3
Query:   66 ESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGM--TLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFI 1811
            ES    ++   WL+AH + ++ L++ S  + L D+N DG+  L+VADL    +    MKLKVY+G +L  E+ IIDLPT +V+F++D N+PRTP +AVASGP+IYVYKN++PYFKFTLP L V   E+++W +  ED ++ + L+E L+ LR+ G   +L+VRS++ L L  E+ME+F +++K  PLK+QTV TC+ T+KKS +++DA+SCLV+GTE+  + ++DPEAFTVL  ++  ++P FM   GLYDVEFR+ VACR+G +Y +KRG+ +AK+ I+L  Q + + R+ K +IVGCMD+TL C+S KG+++W   LPA + +M  +D    G +G +V+L N  + +Y ++ L++ + + DTVT + FG+FGRE  AL+++TR G   +K+LKRTA F  +    GPP AQ  KLN+PKKTK+F+DQ  RERE++V++HR F  DL  LR+T ARSYV  L+   NP+SS   +P+ L+ ++ GIGP FK+ V+++N S   A ++L I F +D  +YA+    I VPLLVPG+SY Y   VECISDKGI+D IKV VL+  ++ PI+T V+NMPVSE  +
Sbjct:    2 ESTTSLKEDDVWLSAHHDPVSSLYTFSSSISLADLNADGDFKLLVADL---GTGTYDMKLKVYKGTNLFMESAIIDLPTALVAFYMDTNDPRTPAVAVASGPFIYVYKNLRPYFKFTLPPLEVNAVEQDLWNQAKEDRIDVQMLREMLESLRSEGSEGSLTVRSLKFLSLHPEEMEDFASLHKMAPLKRQTVITCMNTMKKSVADEDAVSCLVIGTESKDIYILDPEAFTVLSKMSLLSVPAFMSVSGLYDVEFRVIVACRDGKVYTLKRGNKIAKASIELTAQAVGLERIGKNIIVGCMDNTLVCYSTKGKKLWTVYLPANIATMALMDYKARGFKGVMVALTNGEVRLYKDKFLVNTLQMQDTVTAIRFGRFGREDSALILITRGGGFYVKILKRTATFDGKDLTPGPPLAQSVKLNVPKKTKVFVDQTLRERESAVSMHRMFQHDLYLLRLTAARSYVNALQKSLNPVSSSALEPLKLSAQIQGIGPAFKLTVNLQNISPSVAITNLLITFQHDESLYALAKPCIIVPLLVPGLSYSYETLVECISDKGISDAIKVFVLRQGKSVPIITAVINMPVSEALV 582          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Medaka
Match: bbs1 (Bardet-Biedl syndrome 1 [Source:NCBI gene;Acc:101161135])

HSP 1 Score: 530.406 bits (1365), Expect = 0.000e+0
Identity = 259/575 (45.04%), Postives = 386/575 (67.13%), Query Frame = 3
Query:   96 NWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRN-AGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
             WL AH + +A L++ S C+ L D++GDGEN LVV DL    S    MKLKVYRG +L  E  ++DLP G+V+FF+D +EPR P  AVASGP IY+YKN++PYFKFTLPSL V   E+++W++  E  ++   LKE L+ +R  A + LSVRS+R L L  + ++EF  ++K  P+++QTV TC+ TLKKS +++D +SCLVVGTE+  + ++D +AF +L  ++  A P  M   G +DVEFRI VACRNGNIY+++R     K  ++L + P+ ++RV K ++VGC D++L+ F+ KG+++W   LPA + +M  +D    G QG +V L N  + +Y +++L+  I   D VT + FG++GRE   L+M T+ G L++K+LKRT  F  + S  GPP AQ  +LN+PKKTKL++DQ  RERE+ VA+HR F  DL ++R+  A++YV+ LE+   P+S+  S+P+ +   V G+GP+FK+ + ++N++      +LAI F+YD  +Y I D  +++PLLVPG+ YP   +V+C +DKGI D IKV VL    + P++T  +NMPVSE    S
Sbjct:   12 KWLDAHYDPVAGLYTFSSCVDLADLSGDGENRLVVGDLGTGSSG---MKLKVYRGTALMSENTLLDLPAGLVAFFMDLHEPRIPTTAVASGPCIYLYKNLRPYFKFTLPSLEVNTLEQDVWQQAREGQIDPLTLKEMLESIRKKADVPLSVRSLRFLSLETDGLDEFVQLHKQQPIRRQTVITCIDTLKKSTADEDGVSCLVVGTESSDVFILDSKAFIILSKMSLPAPPTMMDVTGQFDVEFRITVACRNGNIYILRRESDKPKYCVELPSHPVGLVRVGKNVLVGCTDESLQGFTQKGKKLWKIVLPAPITTMAPMDLPTRGFQGVLVGLANCEVHLYRDKNLLSTIKTPDVVTSICFGRYGREDGTLIMTTKGGGLMVKILKRTVVFDDRDSAPGPPLAQSIRLNVPKKTKLYVDQTLRERESGVAMHRAFQMDLSRVRLAAAKAYVKALESSLTPMSASLSEPLKMNAVVQGLGPSFKLTLHVQNTAACRPVMNLAISFLYDENLYRIRDPYMRIPLLVPGLIYPVGTFVDCTNDKGITDIIKVFVLHEGRSSPLLTAHINMPVSEGLALS 583          
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Planmine SMEST
Match: SMESG000009880.1 (SMESG000009880.1)

HSP 1 Score: 1194.1 bits (3088), Expect = 0.000e+0
Identity = 592/593 (99.83%), Postives = 593/593 (100.00%), Query Frame = 3
Query:   39 MDKQSEKPTESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLXXXXXXXXXXXXECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 1817
            MDKQSEKPTESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGMTLSVRSIRLLMLSNEKMEEFCNMYK+VPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLVPGVSYPYSVYVECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS
Sbjct:    1 MDKQSEKPTESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGENCLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEPRTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNCEQLKEDLDGLRNAGMTLSVRSIRLLMLSNEKMEEFCNMYKNVPLKKQTVATCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVFMCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNKYLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSLGNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIKLLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHRKFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFKMNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLVPGVSYPYSVYVECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS 593          
The following BLAST results are available for this feature:
BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
BBS11.369e-17343.64Bardet-Biedl syndrome 1 [Source:HGNC Symbol;Acc:HG... [more]
AP002748.58.480e-17343.87novel protein[more]
BBS13.238e-9742.61Bardet-Biedl syndrome 1 [Source:HGNC Symbol;Acc:HG... [more]
BBS11.029e-5839.93Bardet-Biedl syndrome 1 [Source:HGNC Symbol;Acc:HG... [more]
BBS11.989e-3649.25Bardet-Biedl syndrome 1 [Source:HGNC Symbol;Acc:HG... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
bbs-13.373e-7829.41Bardet-Biedl syndrome 1 protein homolog [Source:U... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 1
Match NameE-valueIdentityDescription
BBS15.597e-7726.20gene:FBgn0035741 transcript:FBtr0076912[more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
bbs10.000e+046.84Bardet-Biedl syndrome 1 [Source:ZFIN;Acc:ZDB-GENE-... [more]
bbs10.000e+046.84Bardet-Biedl syndrome 1 [Source:ZFIN;Acc:ZDB-GENE-... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ccdc840.000e+046.90coiled-coil domain containing 84 [Source:Xenbase;A... [more]
ccdc840.000e+046.86coiled-coil domain containing 84 [Source:Xenbase;A... [more]
ccdc840.000e+046.55coiled-coil domain containing 84 [Source:Xenbase;A... [more]
ccdc840.000e+046.52coiled-coil domain containing 84 [Source:Xenbase;A... [more]
ccdc840.000e+045.08coiled-coil domain containing 84 [Source:Xenbase;A... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Bbs11.219e-17843.99Bardet-Biedl syndrome 1 (human) [Source:MGI Symbol... [more]
Bbs11.581e-9742.61Bardet-Biedl syndrome 1 (human) [Source:MGI Symbol... [more]
Bbs12.889e-6346.49Bardet-Biedl syndrome 1 (human) [Source:MGI Symbol... [more]
Bbs11.185e-3342.86Bardet-Biedl syndrome 1 (human) [Source:MGI Symbol... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. UniProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q3V3N7|BBS1_MOUSE8.526e-17843.99Bardet-Biedl syndrome 1 protein homolog OS=Mus mus... [more]
sp|Q8NFJ9|BBS1_HUMAN6.577e-17343.64Bardet-Biedl syndrome 1 protein OS=Homo sapiens OX... [more]
sp|Q9NEZ7|BBS1_CAEEL4.291e-7729.41Bardet-Biedl syndrome 1 protein homolog OS=Caenorh... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
gnl|BL_ORD_ID|203336070.000e+050.42tr|A0A1S3I1L6|A0A1S3I1L6_LINUN Bardet-Biedl syndro... [more]
gnl|BL_ORD_ID|157420500.000e+049.74tr|R7U8T1|R7U8T1_CAPTE BBS1 domain-containing prot... [more]
gnl|BL_ORD_ID|177573180.000e+050.79tr|A0A2G8JHK9|A0A2G8JHK9_STIJA Uncharacterized pro... [more]
gnl|BL_ORD_ID|172329990.000e+049.48tr|A0A433SWB5|A0A433SWB5_ELYCH BBS1 domain-contain... [more]
gnl|BL_ORD_ID|175077580.000e+047.95tr|A7S5W5|A7S5W5_NEMVE Predicted protein OS=Nemato... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
bbs10.000e+046.15Bardet-Biedl syndrome 1 [Source:NCBI gene;Acc:1030... [more]
bbs11.442e-17845.03Bardet-Biedl syndrome 1 [Source:NCBI gene;Acc:1030... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
bbs10.000e+045.74Bardet-Biedl syndrome 1 [Source:ZFIN;Acc:ZDB-GENE-... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO408760.000e+047.95Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
bbs10.000e+045.04Bardet-Biedl syndrome 1 [Source:NCBI gene;Acc:1011... [more]
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BLAST of Bardet-Biedl syndrome 1 protein homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000009880.10.000e+099.83SMESG000009880.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30028417 ID=SMED30028417|Name=Bardet-Biedl syndrome 1 protein homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=1889bp
TCCGATCTATTGACATTAGTTACAAGTGCAATTGAAATATGGATAAACAG
TCTGAAAAACCGACAGAGTCCGACGATAAAGAGGAGAAAAGTAAAAATTG
GCTTACAGCTCATGAAAACACTCTTGCTGATTTGTTTTCCATCTCACAAT
GCATGTGTCTTTGTGATATTAACGGTGATGGAGAGAATTGTCTAGTCGTA
GCAGATTTAACTGACCACAAATCCAAATGCACGCAGATGAAATTAAAAGT
CTATCGAGGAATAAGTCTGACAAAAGAGACCAATATAATTGATTTACCAA
CTGGGGTTGTTAGTTTTTTTCTCGATCGCAATGAACCAAGAACTCCAGGG
CTGGCTGTGGCATCTGGGCCGTATATTTATGTTTATAAAAATATGAAACC
CTATTTCAAATTTACGCTGCCATCTTTACCTGTGATTGAACCCGAAGAAA
ATATCTGGAAAAGGTTTTCTGAGGATTCGGTAAATTGTGAACAACTAAAG
GAAGATTTGGATGGCCTAAGGAATGCCGGCATGACATTGTCGGTCCGTTC
AATTCGGTTATTAATGTTATCTAATGAAAAGATGGAAGAGTTTTGCAATA
TGTATAAAAGCGTACCTTTAAAGAAACAAACTGTGGCGACTTGCTTGACA
ACCTTAAAGAAATCCCATTCAGAAGATGATGCCATTAGTTGCTTGGTAGT
GGGAACGGAGGCCGGCCAGTTATTGGTAATAGACCCGGAAGCATTTACAG
TTTTATATGCAGTAACCTTCAATGCGATTCCAGTATTTATGTGCACCGTT
GGTCTTTATGATGTCGAGTTTCGGATATATGTTGCCTGTAGAAATGGTAA
CATCTATGTCGTTAAGAGGGGTGACACAGTGGCTAAAAGCTTGATTCAAT
TAAACACCCAGCCGTTATCGATGTTGAGAGTAAACAAATATCTAATTGTC
GGGTGCATGGATGACACCTTACGCTGTTTTAGTCCAAAAGGCCGGCAAAT
GTGGTGCAAAACACTTCCAGCGACCCTGATAAGCATGTGCCAGTTAGATA
GCGGCCAGCATGGCGTCCAAGGTACCATTGTTTCACTGGGCAACGACACA
ATTGAAATCTATAATAATCGAGACTTGATCGACAGAATTTCGGTTTCTGA
TACTGTAACCGGTTTGCTGTTCGGTCAGTTTGGCCGGGAACAATTTGCCT
TGTTAATGGTTACTAGAAGTGGGAGTTTGATAATAAAACTGTTGAAGCGA
ACCGCCGATTTCAGCACTCAAACATCAAACAAAGGCCCACCACAAGCCCA
ATTTGAAAAGTTAAACATTCCAAAGAAAACGAAGTTATTTCTTGATCAAG
CCTTTCGAGAGCGGGAAAATTCCGTTGCTATCCACCGGAAATTCATGGAG
GACCTTTGTCAGCTTAGAGTTACAACAGCCAGAAGCTATGTAGAGATATT
GGAAACGAAGCAAAATCCCATTTCTTCTAGGAAGTCTGATCCCATAATAT
TAGCAATTGAGGTGCATGGAATTGGGCCAACTTTTAAAATGAATGTTTCC
ATCAAAAATTCAAGCTTACAGACCGCTTCATCAGACCTTGCTATTTTATT
TGTTTATGACGCAAAGATTTATGCAATTGATGATTCTGTAATTCAGGTTC
CCCTTCTGGTGCCGGGAGTGAGTTACCCGTATTCGGTTTATGTCGAATGC
ATCAGTGACAAGGGAATCGCCGACACGATAAAGGTGCTCGTATTGAAGAA
CAATGAAACCGATCCCATAGTTACCGGGGTGGTCAACATGCCGGTCAGTG
AAACCTTCATTGCCAGCTGACCGCAACAAGCGAGGCCCCCCAATCCAGTC
CATCTGATAATTGTGTTGTTGTGAATAAATGAAATCTGT
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protein sequence of SMED30028417-orf-1

>SMED30028417-orf-1 ID=SMED30028417-orf-1|Name=SMED30028417-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=594bp
MDKQSEKPTESDDKEEKSKNWLTAHENTLADLFSISQCMCLCDINGDGEN
CLVVADLTDHKSKCTQMKLKVYRGISLTKETNIIDLPTGVVSFFLDRNEP
RTPGLAVASGPYIYVYKNMKPYFKFTLPSLPVIEPEENIWKRFSEDSVNC
EQLKEDLDGLRNAGMTLSVRSIRLLMLSNEKMEEFCNMYKSVPLKKQTVA
TCLTTLKKSHSEDDAISCLVVGTEAGQLLVIDPEAFTVLYAVTFNAIPVF
MCTVGLYDVEFRIYVACRNGNIYVVKRGDTVAKSLIQLNTQPLSMLRVNK
YLIVGCMDDTLRCFSPKGRQMWCKTLPATLISMCQLDSGQHGVQGTIVSL
GNDTIEIYNNRDLIDRISVSDTVTGLLFGQFGREQFALLMVTRSGSLIIK
LLKRTADFSTQTSNKGPPQAQFEKLNIPKKTKLFLDQAFRERENSVAIHR
KFMEDLCQLRVTTARSYVEILETKQNPISSRKSDPIILAIEVHGIGPTFK
MNVSIKNSSLQTASSDLAILFVYDAKIYAIDDSVIQVPLLVPGVSYPYSV
YVECISDKGIADTIKVLVLKNNETDPIVTGVVNMPVSETFIAS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000028Category 2 cell
PLANA:0000034epidermis
PLANA:0000035Category 3 cell
PLANA:0000044cephalic ganglia
PLANA:0000055dorsal stripe
PLANA:0000096ventral epidermis
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR028784BBS1
IPR015943WD40/YVTN_repeat-like_dom_sf
IPR032728BBS1_N
IPR011047Quinoprotein_ADH-like_supfam
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0034464BBSome
Vocabulary: biological process
TermDefinition
GO:1905515non-motile cilium assembly
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR015943WD40/YVTN repeat-like-containing domain superfamilyGENE3DG3DSA:2.130.10.10coord: 204..361
e-value: 2.0E-5
score: 25.9
IPR032728Bardet-Biedl syndrome 1, N-terminalPFAMPF14779BBS1coord: 21..276
e-value: 6.0E-99
score: 330.6
IPR028784Bardet-Biedl syndrome 1 proteinPANTHERPTHR20870BARDET-BIEDL SYNDROME 1 PROTEINcoord: 15..590
IPR011047Quinoprotein alcohol dehydrogenase-like superfamilySUPERFAMILYSSF50998Quinoprotein alcohol dehydrogenase-likecoord: 219..353